[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) :

chr14:103,161,201-104,892,153

Best TWAS P=8.74e-14 · Best GWAS P=1.23e-13 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TRMT61A 0.06 0.03 lasso 3 0.04 6.6e-06 -6.8 6.8 1.2e-11 -0.60 0.37 0.58 FALSE
2 GTEx Adipose Subcutaneous MARK3 0.12 0.05 lasso 3 0.06 2.5e-05 4.2 5.5 3.7e-08 -0.41 0.77 0.12 FALSE
3 GTEx Adipose Subcutaneous RP11-73M18.6 0.08 0.05 lasso 4 0.05 3.7e-05 -5.5 5.7 1.2e-08 -0.63 0.76 0.08 TRUE
4 GTEx Adipose Visceral Omentum RP11-73M18.8 0.16 0.07 lasso 5 0.10 1.1e-05 -5.1 6.1 8.0e-10 -0.66 0.73 0.07 TRUE
5 GTEx Adrenal Gland RP11-73M18.8 0.16 0.09 lasso 4 0.06 3.2e-03 -5.9 5.3 9.6e-08 -0.62 0.40 0.23 FALSE
6 GTEx Artery Tibial TRMT61A 0.07 0.07 lasso 3 0.06 2.4e-05 4.7 5.1 2.7e-07 -0.31 0.89 0.01 FALSE
7 GTEx Brain Cortex RP11-73M18.8 0.35 0.13 enet 34 0.25 1.2e-07 4.4 7.5 8.7e-14 -0.69 0.05 0.94 TRUE
8 GTEx Brain Nucleus accumbens basal ganglia RP11-73M18.8 0.12 0.03 lasso 4 0.01 1.4e-01 -6.1 6.8 1.1e-11 -0.75 0.04 0.57 FALSE
9 GTEx Breast Mammary Tissue RP11-73M18.8 0.19 0.14 enet 21 0.26 2.0e-13 4.0 6.1 8.3e-10 -0.69 0.13 0.87 FALSE
10 GTEx Breast Mammary Tissue (Female) XRCC3 0.19 0.03 enet 27 0.09 1.5e-03 4.1 5.1 2.7e-07 -0.52 0.29 0.08 FALSE
11 GTEx Breast Mammary Tissue (Female) RP11-73M18.8 0.21 0.09 enet 12 0.16 1.3e-05 -7.4 7.0 2.9e-12 -0.82 0.01 0.98 FALSE
12 GTEx Cells Transformed fibroblasts XRCC3 0.24 0.04 enet 34 0.08 2.7e-06 3.6 5.8 6.2e-09 -0.53 0.70 0.28 FALSE
13 GTEx Cells Transformed fibroblasts RP11-73M18.8 0.17 0.08 enet 15 0.10 3.1e-08 -4.4 5.9 3.0e-09 -0.64 0.22 0.78 FALSE
14 GTEx Colon Transverse RP11-73M18.8 0.26 0.04 enet 23 0.06 8.4e-04 -5.4 6.1 7.9e-10 -0.63 0.58 0.30 FALSE
15 GTEx Esophagus Mucosa MARK3 0.11 0.03 lasso 4 0.04 1.5e-03 -5.8 -5.1 2.9e-07 0.63 0.03 0.86 TRUE
16 GTEx Esophagus Mucosa RP11-73M18.8 0.11 0.06 lasso 12 0.10 2.1e-07 4.0 5.9 4.3e-09 -0.60 0.94 0.03 FALSE
17 GTEx Esophagus Muscularis APOPT1 0.16 0.02 enet 11 0.04 2.2e-03 -7.4 -5.4 7.2e-08 0.78 0.00 0.98 FALSE
18 GTEx Nerve Tibial TRMT61A 0.10 0.00 lasso 5 0.01 1.0e-01 -6.1 6.9 4.4e-12 -0.71 0.14 0.67 FALSE
19 GTEx Skin Not Sun Exposed Suprapubic RP11-73M18.8 0.10 0.01 lasso 6 0.02 3.8e-02 3.1 5.3 1.2e-07 -0.69 0.19 0.39 FALSE
20 GTEx Skin Sun Exposed Lower leg BAG5 0.06 0.05 lasso 1 0.06 1.8e-05 -6.1 6.1 8.5e-10 -0.71 0.04 0.94 FALSE
21 GTEx Spleen RP11-73M18.8 0.33 0.37 lasso 3 0.36 5.2e-10 -5.5 5.7 1.5e-08 -0.61 0.76 0.20 FALSE
22 GTEx Thyroid TRMT61A 0.11 0.03 lasso 4 0.02 1.2e-02 -5.4 5.3 1.2e-07 -0.55 0.17 0.72 FALSE
23 GTEx Thyroid RP11-73M18.8 0.15 0.11 enet 12 0.10 2.8e-08 -4.4 5.4 8.4e-08 -0.51 0.97 0.02 FALSE
24 GTEx Uterus RP11-73M18.8 0.34 0.12 lasso 5 0.18 1.6e-04 -4.4 5.3 1.3e-07 -0.59 0.08 0.44 FALSE
25 GTEx Whole Blood RP11-73M18.8 0.13 0.10 lasso 5 0.14 1.4e-12 3.8 5.5 4.0e-08 -0.58 0.90 0.10 FALSE
26 METSIM Adipose BAG5 0.06 0.07 lasso 3 0.07 4.5e-10 -6.1 6.3 2.5e-10 -0.73 0.86 0.14 FALSE
27 NTR Blood KLC1 0.04 0.02 blup 393 0.04 8.2e-12 3.8 5.2 1.7e-07 -0.49 1.00 0.00 FALSE
28 YFS Blood BAG5 0.01 0.01 bslmm 350 0.00 1.9e-02 4.0 6.3 3.7e-10 -0.64 0.06 0.68 FALSE
29 YFS Blood CKB 0.03 0.02 lasso 4 0.02 6.6e-07 -7.4 7.2 7.3e-13 -0.98 0.00 1.00 TRUE
30 YFS Blood MARK3 0.04 0.04 lasso 3 0.04 1.6e-12 -5.5 -5.4 5.6e-08 0.46 1.00 0.00 FALSE
31 YFS Blood TRMT61A 0.08 0.11 lasso 4 0.12 1.6e-37 3.1 5.3 1.3e-07 -0.72 1.00 0.00 FALSE
32 YFS Blood ZFYVE21 0.01 0.00 blup 339 0.00 8.9e-03 -4.8 6.6 3.0e-11 -0.72 0.07 0.75 TRUE
33 The Cancer Genome Atlas Breast Invasive Carcinoma BAG5 0.01 0.02 lasso 3 0.01 7.6e-04 -6.0 6.4 1.8e-10 -0.65 0.14 0.36 FALSE
34 The Cancer Genome Atlas Breast Invasive Carcinoma CKB 0.06 0.03 lasso 3 0.03 2.5e-06 5.1 5.7 9.8e-09 -0.59 0.23 0.72 TRUE
35 The Cancer Genome Atlas Esophageal Carcinoma PPP1R13B 0.26 0.03 enet 12 0.12 1.4e-04 -5.4 -5.6 2.0e-08 0.60 0.00 0.93 FALSE
36 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BAG5 0.06 0.02 blup 30 0.03 1.4e-04 -5.4 7.3 3.3e-13 -0.65 0.07 0.83 FALSE
37 The Cancer Genome Atlas Brain Lower Grade Glioma XRCC3 0.06 0.03 blup 46 0.06 2.3e-07 4.0 5.5 4.1e-08 -0.57 0.02 0.96 FALSE
38 The Cancer Genome Atlas Lung Squamous Cell Carcinoma BAG5 0.03 0.03 lasso 1 0.02 9.5e-04 -5.9 5.9 3.3e-09 -0.68 0.15 0.13 FALSE
39 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TRMT61A 0.02 0.00 blup 34 0.01 6.2e-02 -6.1 6.6 4.3e-11 -0.58 0.03 0.22 FALSE
40 The Cancer Genome Atlas Prostate Adenocarcinoma BAG5 0.04 0.05 lasso 2 0.04 9.1e-05 -6.1 6.1 8.3e-10 -0.71 0.66 0.18 TRUE
41 The Cancer Genome Atlas Prostate Adenocarcinoma TRMT61A 0.03 0.01 blup 32 0.01 1.4e-02 4.7 5.1 2.7e-07 -0.39 0.02 0.04 FALSE
42 The Cancer Genome Atlas Rectum Adenocarcinoma BAG5 0.17 -0.01 blup 32 0.02 1.3e-01 -6.8 6.0 2.0e-09 -0.57 0.01 0.14 FALSE