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chr14:103,161,201-104,892,153

Best TWAS P=8.74e-14 · Best GWAS P=1.23e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TRMT61A	0.06	0.03	lasso	3	0.04	6.6e-06	-6.8	6.8	1.2e-11	-0.60	0.37	0.58	FALSE
2	GTEx	Adipose Subcutaneous	MARK3	0.12	0.05	lasso	3	0.06	2.5e-05	4.2	5.5	3.7e-08	-0.41	0.77	0.12	FALSE
3	GTEx	Adipose Subcutaneous	RP11-73M18.6	0.08	0.05	lasso	4	0.05	3.7e-05	-5.5	5.7	1.2e-08	-0.63	0.76	0.08	TRUE
4	GTEx	Adipose Visceral Omentum	RP11-73M18.8	0.16	0.07	lasso	5	0.10	1.1e-05	-5.1	6.1	8.0e-10	-0.66	0.73	0.07	TRUE
5	GTEx	Adrenal Gland	RP11-73M18.8	0.16	0.09	lasso	4	0.06	3.2e-03	-5.9	5.3	9.6e-08	-0.62	0.40	0.23	FALSE
6	GTEx	Artery Tibial	TRMT61A	0.07	0.07	lasso	3	0.06	2.4e-05	4.7	5.1	2.7e-07	-0.31	0.89	0.01	FALSE
7	GTEx	Brain Cortex	RP11-73M18.8	0.35	0.13	enet	34	0.25	1.2e-07	4.4	7.5	8.7e-14	-0.69	0.05	0.94	TRUE
8	GTEx	Brain Nucleus accumbens basal ganglia	RP11-73M18.8	0.12	0.03	lasso	4	0.01	1.4e-01	-6.1	6.8	1.1e-11	-0.75	0.04	0.57	FALSE
9	GTEx	Breast Mammary Tissue	RP11-73M18.8	0.19	0.14	enet	21	0.26	2.0e-13	4.0	6.1	8.3e-10	-0.69	0.13	0.87	FALSE
10	GTEx	Breast Mammary Tissue (Female)	XRCC3	0.19	0.03	enet	27	0.09	1.5e-03	4.1	5.1	2.7e-07	-0.52	0.29	0.08	FALSE
11	GTEx	Breast Mammary Tissue (Female)	RP11-73M18.8	0.21	0.09	enet	12	0.16	1.3e-05	-7.4	7.0	2.9e-12	-0.82	0.01	0.98	FALSE
12	GTEx	Cells Transformed fibroblasts	XRCC3	0.24	0.04	enet	34	0.08	2.7e-06	3.6	5.8	6.2e-09	-0.53	0.70	0.28	FALSE
13	GTEx	Cells Transformed fibroblasts	RP11-73M18.8	0.17	0.08	enet	15	0.10	3.1e-08	-4.4	5.9	3.0e-09	-0.64	0.22	0.78	FALSE
14	GTEx	Colon Transverse	RP11-73M18.8	0.26	0.04	enet	23	0.06	8.4e-04	-5.4	6.1	7.9e-10	-0.63	0.58	0.30	FALSE
15	GTEx	Esophagus Mucosa	MARK3	0.11	0.03	lasso	4	0.04	1.5e-03	-5.8	-5.1	2.9e-07	0.63	0.03	0.86	TRUE
16	GTEx	Esophagus Mucosa	RP11-73M18.8	0.11	0.06	lasso	12	0.10	2.1e-07	4.0	5.9	4.3e-09	-0.60	0.94	0.03	FALSE
17	GTEx	Esophagus Muscularis	APOPT1	0.16	0.02	enet	11	0.04	2.2e-03	-7.4	-5.4	7.2e-08	0.78	0.00	0.98	FALSE
18	GTEx	Nerve Tibial	TRMT61A	0.10	0.00	lasso	5	0.01	1.0e-01	-6.1	6.9	4.4e-12	-0.71	0.14	0.67	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	RP11-73M18.8	0.10	0.01	lasso	6	0.02	3.8e-02	3.1	5.3	1.2e-07	-0.69	0.19	0.39	FALSE
20	GTEx	Skin Sun Exposed Lower leg	BAG5	0.06	0.05	lasso	1	0.06	1.8e-05	-6.1	6.1	8.5e-10	-0.71	0.04	0.94	FALSE
21	GTEx	Spleen	RP11-73M18.8	0.33	0.37	lasso	3	0.36	5.2e-10	-5.5	5.7	1.5e-08	-0.61	0.76	0.20	FALSE
22	GTEx	Thyroid	TRMT61A	0.11	0.03	lasso	4	0.02	1.2e-02	-5.4	5.3	1.2e-07	-0.55	0.17	0.72	FALSE
23	GTEx	Thyroid	RP11-73M18.8	0.15	0.11	enet	12	0.10	2.8e-08	-4.4	5.4	8.4e-08	-0.51	0.97	0.02	FALSE
24	GTEx	Uterus	RP11-73M18.8	0.34	0.12	lasso	5	0.18	1.6e-04	-4.4	5.3	1.3e-07	-0.59	0.08	0.44	FALSE
25	GTEx	Whole Blood	RP11-73M18.8	0.13	0.10	lasso	5	0.14	1.4e-12	3.8	5.5	4.0e-08	-0.58	0.90	0.10	FALSE
26	METSIM	Adipose	BAG5	0.06	0.07	lasso	3	0.07	4.5e-10	-6.1	6.3	2.5e-10	-0.73	0.86	0.14	FALSE
27	NTR	Blood	KLC1	0.04	0.02	blup	393	0.04	8.2e-12	3.8	5.2	1.7e-07	-0.49	1.00	0.00	FALSE
28	YFS	Blood	BAG5	0.01	0.01	bslmm	350	0.00	1.9e-02	4.0	6.3	3.7e-10	-0.64	0.06	0.68	FALSE
29	YFS	Blood	CKB	0.03	0.02	lasso	4	0.02	6.6e-07	-7.4	7.2	7.3e-13	-0.98	0.00	1.00	TRUE
30	YFS	Blood	MARK3	0.04	0.04	lasso	3	0.04	1.6e-12	-5.5	-5.4	5.6e-08	0.46	1.00	0.00	FALSE
31	YFS	Blood	TRMT61A	0.08	0.11	lasso	4	0.12	1.6e-37	3.1	5.3	1.3e-07	-0.72	1.00	0.00	FALSE
32	YFS	Blood	ZFYVE21	0.01	0.00	blup	339	0.00	8.9e-03	-4.8	6.6	3.0e-11	-0.72	0.07	0.75	TRUE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	BAG5	0.01	0.02	lasso	3	0.01	7.6e-04	-6.0	6.4	1.8e-10	-0.65	0.14	0.36	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	CKB	0.06	0.03	lasso	3	0.03	2.5e-06	5.1	5.7	9.8e-09	-0.59	0.23	0.72	TRUE
35	The Cancer Genome Atlas	Esophageal Carcinoma	PPP1R13B	0.26	0.03	enet	12	0.12	1.4e-04	-5.4	-5.6	2.0e-08	0.60	0.00	0.93	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BAG5	0.06	0.02	blup	30	0.03	1.4e-04	-5.4	7.3	3.3e-13	-0.65	0.07	0.83	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	XRCC3	0.06	0.03	blup	46	0.06	2.3e-07	4.0	5.5	4.1e-08	-0.57	0.02	0.96	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	BAG5	0.03	0.03	lasso	1	0.02	9.5e-04	-5.9	5.9	3.3e-09	-0.68	0.15	0.13	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRMT61A	0.02	0.00	blup	34	0.01	6.2e-02	-6.1	6.6	4.3e-11	-0.58	0.03	0.22	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	BAG5	0.04	0.05	lasso	2	0.04	9.1e-05	-6.1	6.1	8.3e-10	-0.71	0.66	0.18	TRUE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRMT61A	0.03	0.01	blup	32	0.01	1.4e-02	4.7	5.1	2.7e-07	-0.39	0.02	0.04	FALSE
42	The Cancer Genome Atlas	Rectum Adenocarcinoma	BAG5	0.17	-0.01	blup	32	0.02	1.3e-01	-6.8	6.0	2.0e-09	-0.57	0.01	0.14	FALSE