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chr15:81,636,267-84,072,745

Best TWAS P=3.77e-11 · Best GWAS P=6.45e-10 conditioned to 0.321

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	AP3B2	0.53	0.41	lasso	3	0.41	4.7e-36	5.9	5.9	4.6e-09	0.48	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	AP3B2	0.50	0.45	lasso	5	0.47	8.2e-27	5.9	5.8	6.1e-09	0.46	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-152F13.3	0.09	0.03	lasso	3	0.03	1.3e-02	6.2	-6.3	2.7e-10	-1.00	0.00	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-152F13.7	0.14	0.01	enet	12	0.07	1.9e-04	-5.5	-5.3	9.2e-08	-0.70	0.02	0.88	FALSE
5	GTEx	Adrenal Gland	RP11-152F13.3	0.10	0.07	lasso	4	0.04	2.0e-02	-5.2	-6.3	3.9e-10	-0.86	0.01	0.88	FALSE
6	GTEx	Artery Aorta	AP3B2	0.18	0.11	lasso	2	0.11	2.0e-06	5.9	5.9	3.4e-09	0.48	0.00	1.00	FALSE
7	GTEx	Artery Tibial	AP3B2	0.18	0.17	enet	12	0.15	6.7e-12	5.9	5.3	9.1e-08	0.47	0.00	1.00	FALSE
8	GTEx	Breast Mammary Tissue	AP3B2	0.40	0.24	lasso	5	0.24	1.9e-12	5.9	6.1	1.4e-09	0.51	0.00	1.00	FALSE
9	GTEx	Breast Mammary Tissue	RP11-152F13.3	0.13	0.08	enet	8	0.11	2.9e-06	5.4	-5.4	8.0e-08	-0.56	0.16	0.79	FALSE
10	GTEx	Breast Mammary Tissue (Male)	AP3B2	0.20	0.23	lasso	2	0.20	1.7e-05	5.9	5.8	5.0e-09	0.47	0.00	0.98	FALSE
11	GTEx	Breast Mammary Tissue (Female)	AP3B2	0.35	0.27	lasso	2	0.26	1.8e-08	5.9	5.9	3.0e-09	0.50	0.00	1.00	FALSE
12	GTEx	Breast Mammary Tissue (Female)	RP11-152F13.3	0.04	-0.01	enet	7	-0.01	7.9e-01	6.2	-6.6	3.8e-11	-0.86	0.01	0.48	TRUE
13	GTEx	Breast Mammary Tissue (Female)	RP11-152F13.7	0.08	0.03	lasso	4	0.03	5.0e-02	4.6	-5.4	7.9e-08	-0.59	0.03	0.14	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	RP11-152F13.3	0.31	0.10	enet	14	0.17	3.2e-06	-3.4	-6.3	3.1e-10	-0.79	0.03	0.94	FALSE
15	GTEx	Cells Transformed fibroblasts	AP3B2	0.65	0.36	lasso	7	0.30	4.1e-23	5.9	5.8	5.1e-09	0.48	0.00	1.00	FALSE
16	GTEx	Cells Transformed fibroblasts	EFTUD1	0.17	0.12	lasso	7	0.14	9.0e-11	4.5	5.3	1.0e-07	0.48	0.32	0.68	FALSE
17	GTEx	Cells Transformed fibroblasts	MEX3B	0.18	0.12	enet	18	0.10	3.0e-08	4.5	5.4	5.1e-08	0.45	0.86	0.13	FALSE
18	GTEx	Cells Transformed fibroblasts	RP11-152F13.7	0.29	0.12	lasso	7	0.18	2.2e-13	-5.5	-5.3	1.1e-07	-0.69	0.16	0.84	FALSE
19	GTEx	Colon Transverse	AP3B2	0.17	0.16	lasso	3	0.15	1.4e-07	5.9	5.9	3.2e-09	0.47	0.00	1.00	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	AP3B2	0.33	0.39	lasso	3	0.37	1.7e-14	5.9	5.9	4.3e-09	0.47	0.00	1.00	FALSE
21	GTEx	Esophagus Mucosa	AP3B2	0.40	0.25	lasso	3	0.24	1.7e-16	5.9	5.8	5.0e-09	0.47	0.00	1.00	FALSE
22	GTEx	Esophagus Mucosa	EFTUD1	0.09	0.06	enet	10	0.08	9.0e-06	5.5	5.5	4.2e-08	0.56	0.24	0.70	FALSE
23	GTEx	Esophagus Muscularis	AP3B2	0.67	0.46	lasso	5	0.44	3.0e-29	5.9	5.9	4.3e-09	0.47	0.00	1.00	FALSE
24	GTEx	Heart Atrial Appendage	AP3B2	0.27	0.23	enet	10	0.26	7.6e-12	5.5	5.4	8.1e-08	0.42	0.00	1.00	FALSE
25	GTEx	Heart Left Ventricle	RP11-152F13.3	0.16	0.05	lasso	5	0.06	4.0e-04	5.2	-5.2	2.1e-07	-0.52	0.22	0.66	FALSE
26	GTEx	Lung	AP3B2	0.14	0.13	lasso	4	0.12	1.4e-09	5.9	5.7	1.3e-08	0.45	0.00	1.00	FALSE
27	GTEx	Muscle Skeletal	EFTUD1	0.08	0.02	enet	24	0.05	6.3e-06	-5.4	5.6	1.6e-08	0.53	0.22	0.68	FALSE
28	GTEx	Nerve Tibial	AP3B2	0.52	0.38	lasso	7	0.43	3.6e-33	5.9	5.8	6.4e-09	0.48	0.00	1.00	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	AP3B2	0.45	0.41	lasso	6	0.42	1.2e-24	5.9	6.0	2.3e-09	0.53	0.00	1.00	FALSE
30	GTEx	Skin Sun Exposed Lower leg	AP3B2	0.32	0.26	lasso	4	0.27	2.8e-22	5.9	5.9	4.4e-09	0.47	0.00	1.00	FALSE
31	GTEx	Stomach	AP3B2	0.36	0.23	enet	9	0.21	2.1e-10	5.9	5.9	4.9e-09	0.51	0.00	1.00	FALSE
32	GTEx	Testis	RP11-152F13.3	0.11	0.09	lasso	4	0.06	1.4e-03	-5.2	-5.4	7.4e-08	-0.68	0.09	0.34	FALSE
33	GTEx	Thyroid	AP3B2	0.37	0.30	lasso	3	0.29	9.8e-23	5.9	6.1	9.7e-10	0.49	0.00	1.00	FALSE
34	GTEx	Thyroid	GOLGA6L9	0.12	0.02	lasso	4	0.01	6.5e-02	5.6	5.4	7.9e-08	0.48	0.01	0.87	FALSE
35	GTEx	Uterus	AP3B2	0.43	0.37	lasso	2	0.27	2.6e-06	5.2	5.1	2.7e-07	0.43	0.01	0.95	FALSE
36	GTEx	Whole Blood	AP3B2	0.06	0.04	enet	6	0.03	1.1e-03	5.2	5.8	7.4e-09	0.48	0.01	0.98	FALSE
37	METSIM	Adipose	AP3B2	0.19	0.21	enet	12	0.21	8.7e-31	5.5	5.2	1.9e-07	0.43	0.02	0.98	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	RP13-996F3.3	0.67	0.23	enet	76	0.42	2.6e-59	5.6	-5.8	7.1e-09	-0.51	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AP3B2	0.07	0.02	blup	54	0.03	1.3e-03	3.9	5.5	3.8e-08	0.46	0.02	0.81	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GOLGA6L9	0.15	0.08	blup	40	0.08	4.5e-07	-5.4	-5.8	8.6e-09	-0.69	0.23	0.76	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC80154	0.16	0.10	lasso	2	0.09	5.0e-08	5.5	-5.3	9.6e-08	-0.49	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3B2	0.02	0.03	lasso	3	0.03	1.9e-06	5.4	5.4	6.3e-08	0.42	0.00	0.99	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AP3B2	0.16	0.14	lasso	4	0.15	3.2e-16	5.5	5.5	3.1e-08	0.45	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GOLGA6L9	0.10	0.10	lasso	4	0.10	4.3e-11	-5.4	-5.4	7.2e-08	-0.69	0.27	0.73	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFTUD1	0.06	0.02	blup	96	0.06	7.3e-07	-5.9	6.6	5.5e-11	0.57	0.07	0.91	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GOLGA6L9	0.15	0.07	lasso	2	0.07	1.4e-08	-5.4	-5.2	1.7e-07	-0.73	0.22	0.78	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC80154	0.08	0.06	blup	8	0.06	1.5e-07	5.5	-5.1	2.7e-07	-0.47	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	AP3B2	0.06	0.06	lasso	1	0.06	1.8e-07	5.5	5.5	3.8e-08	0.42	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC80154	0.09	0.06	lasso	3	0.06	1.4e-07	5.5	-5.3	1.2e-07	-0.48	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	AP3B2	0.06	0.05	lasso	2	0.04	6.9e-06	5.5	5.6	2.3e-08	0.43	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GOLGA6L9	0.07	0.04	blup	40	0.06	3.3e-07	6.2	-6.0	1.6e-09	-0.87	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EFTUD1	0.05	0.02	blup	95	0.02	2.1e-02	4.6	5.5	3.3e-08	0.49	0.06	0.16	FALSE
53	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GOLGA6L9	0.12	0.05	lasso	3	0.05	4.0e-04	-5.5	-5.5	3.7e-08	-0.74	0.10	0.77	FALSE
54	The Cancer Genome Atlas	Soft Tissue Sarcoma	AP3B2	0.13	0.10	lasso	1	0.09	7.3e-06	5.5	5.5	3.8e-08	0.45	0.00	0.99	FALSE
55	The Cancer Genome Atlas	Skin Cutaneous Melanoma	GOLGA6L9	0.34	0.22	lasso	3	0.21	2.2e-06	-5.4	-5.6	1.8e-08	-0.69	0.15	0.62	FALSE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC80154	0.11	0.06	lasso	2	0.05	8.5e-05	5.5	-5.6	1.8e-08	-0.55	0.00	0.98	FALSE
57	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC80154	0.13	0.08	lasso	1	0.06	4.9e-03	5.5	-5.5	4.0e-08	-0.52	0.00	0.83	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	AP3B2	0.13	0.09	enet	8	0.10	9.5e-10	5.5	5.3	1.0e-07	0.40	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	LOC80154	0.04	0.03	lasso	2	0.02	5.7e-03	5.5	-5.2	1.7e-07	-0.47	0.00	0.90	FALSE