Hub : Genes

MEX3B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.180	0.0550	2.1e-05	0.123	NA	0.133	NA	0.150	2.9e-07	NA	8.7e-08	NA	1.2e-08
2	GTEx	Cells Transformed fibroblasts	0.184	0.0460	6.0e-07	0.115	NA	0.105	NA	0.104	6.0e-09	NA	3.0e-08	NA	3.2e-08
3	GTEx	Lung	0.101	0.0364	4.7e-04	-0.003	NA	0.000	NA	-0.001	7.4e-01	NA	3.3e-01	NA	3.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.9	3.0	4.4	-1.5	-1.6	2.1
Bipolar Disorder or Schizophrenia	3.3	8.1	10.2	-2.1	-3.1	3.2
Depressed Affect (Nagel 2018)	0.8	1.7	4.3	2.1	-0.8	0.3
Depression (Nagel 2018)	0.9	1.3	1.9	0.7	-1.3	1.4
Intelligence (Savage-Jansen 2018)	5.1	15.8	29.7	4.1	5.4	-1.0
Neuroticism (Nagel 2018)	0.5	1.1	2.7	1.6	-0.3	0.7
Schizophrenia (2018)	2.5	5.2	7.5	-1.5	-2.7	2.4
Schizophrenia vs Biploar Disorder	1.2	1.6	4.7	-0.1	0.1	2.2
Worry (Nagel 2018)	0.2	0.5	1.0	1.0	-0.1	0.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	1.3	-0.5	-0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.3	-0.7	0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.4	0.6	-1.2	-0.2
Crohns Disease (2017)	0.4	1.0	2.2	-1.5	-0.6	0.6
Irritable Bowel Disease (IBD)	0.4	1.0	2.5	-1.6	-0.7	0.3
Ulcerative Colitis (UC)	0.7	1.2	2.6	-1.6	-0.4	1.0
Major Depression (MDD)	0.5	0.6	0.9	0.8	1.0	-0.5
Reaction Time	0.0	0.1	0.1	-0.2	0.2	0.3
Verbal and Numeric Reasoning (VNR)	3.1	7.4	10.1	2.6	3.2	-2.3
Breast Cancer	0.6	1.3	2.9	0.2	-1.0	-1.7
Ovarian Cancer	0.7	1.0	2.2	-0.5	-1.5	-0.7
Prostate Cancer	1.0	1.4	3.6	0.7	0.3	-1.9
Age at First Birth	0.9	1.3	2.8	1.0	0.1	1.7
Bipolar Disorder (2011)	0.3	0.3	0.4	-0.4	-0.5	0.7
Body Mass Index (BMI) (2010)	2.6	3.6	10.4	-3.2	-0.2	0.7
Coronary Artery Disease (CAD)	1.5	1.8	4.5	2.1	-0.9	0.0
Crohns Disease (2012)	0.5	0.8	1.3	-1.1	-1.0	0.5
Mean Putamen Volume	0.3	0.4	0.7	0.7	-0.8	0.2
Fasting Glucose	2.3	2.7	4.1	-1.9	0.5	2.0
HbA1C	1.4	1.6	2.6	1.3	0.7	-1.6
HDL Cholesterol	0.2	0.4	0.8	0.9	-0.4	0.5
LDL Cholesterol	0.5	0.7	1.6	0.5	0.6	1.3
Lupus	0.2	0.3	0.5	-0.7	-0.7	-0.1
Neuroticism (2016)	0.5	0.8	1.4	1.0	1.2	0.1
Primary Biliary Cirrhosis	0.2	0.3	0.4	-0.6	-0.6	0.3
Rheumatoid Arthritis	0.1	0.2	0.4	0.4	-0.7	-0.0
Schizophrenia (2014)	1.9	4.3	9.0	-0.8	-1.8	3.0
Triglycerides	0.3	0.5	0.9	0.3	0.8	-1.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.5	0.2	-0.6	0.7
Ulcerative Colitis	0.3	0.5	0.8	-0.9	-0.8	0.3
Blood Eosinophil Count	0.2	1.2	2.2	0.1	-1.5	1.2
Blood Platelet Count	0.0	0.1	0.2	-0.5	0.3	0.2
Blood Red Count	1.5	14.1	25.5	4.1	5.0	-0.3
Blood White Count	0.0	0.1	0.1	0.4	0.1	-0.3
Heel T-Score	0.0	0.2	0.3	-0.1	0.5	-0.4
BMI	0.2	1.4	2.2	-1.5	-0.2	1.4
Height	0.4	8.2	19.9	4.5	-0.6	-2.1
Waist Hip Ratio (WHR)	2.6	11.9	22.8	4.8	2.5	-2.6
Systolic Blood Pressure	0.2	1.0	2.7	0.6	0.1	-1.6
Smoking Status	1.4	3.4	8.9	-1.1	-3.0	0.0
Allergy or Eczema	0.1	0.2	0.5	-0.4	0.2	0.7
Cardiovascular Disease	0.2	0.7	1.6	-1.3	-0.5	-0.5
Hypothyroidism (self reported)	0.5	1.1	1.8	1.4	-1.2	-0.2
Respiratory disease	0.2	0.3	0.6	-0.2	0.8	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.3	-0.3	-0.6
Lung FEV1/FVC ratio	0.5	2.7	7.1	2.7	0.6	-0.7
Lung FVC	0.9	4.6	12.0	-1.3	3.5	-0.4
Neuroticism	0.5	1.2	2.3	1.1	0.3	1.5
Chronotype (morning person)	0.8	1.9	4.5	0.7	0.9	2.1
Hair Pigment	0.5	13.4	30.2	2.3	5.5	-2.1
Tanning	1.3	15.8	23.9	-4.5	-4.9	1.9
Hand grip strength (left)	0.3	0.7	1.4	0.7	-1.2	-0.5
Number of treatments/medications taken	0.1	0.1	0.3	0.1	0.5	-0.3
Average weekly spirits intake	0.9	1.1	1.4	-1.2	-0.8	1.1
Sensitivity / hurt feelings	4.0	6.9	19.2	-0.7	-0.9	4.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.3	1.8	-0.4	1.4
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.4	-0.1	0.4
Relative age of first facial hair	1.0	2.0	4.1	1.2	2.0	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.7	0.3	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.0	-0.1	1.4	0.3
Ever had hysterectomy (womb removed)	0.3	0.3	0.4	0.5	0.6	0.5
Systolic blood pressure, automated reading	0.2	0.5	1.3	-0.4	-0.2	-1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	-0.3	-0.6	-0.9
Angina	1.4	1.9	3.3	-0.8	-1.8	1.3
Medication for hormone replacement therapy	1.2	1.4	1.9	1.1	1.0	-1.4
Vitamin and mineral supplements	2.5	3.4	6.2	-1.9	-2.5	-0.7
Supplements: Zinc	1.2	1.3	2.3	1.5	1.3	-0.1
Medication: Co-codamol	1.6	1.8	4.9	-0.7	-2.2	0.4
Medication: Metformin	0.8	1.1	3.2	0.0	0.1	-1.8
Diabetes (father)	2.6	3.3	3.7	-1.8	-1.9	1.7
Diabetes (mother)	0.9	1.2	2.6	1.0	1.6	0.1
Severe depression (siblings)	1.5	1.6	3.7	-0.3	1.1	-1.9
Pack years adult smoking proportion	1.1	1.6	2.5	1.4	-0.6	-1.6
Impedance of leg (right)	0.4	2.1	4.8	2.2	-1.0	-0.7
Leg fat-free mass (left)	0.0	0.1	0.2	0.4	0.1	-0.4
Trunk fat percentage	0.2	0.7	1.8	0.0	-1.3	0.4
Hand grip strength (right)	0.6	1.7	2.6	1.5	-0.6	-1.6
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.5	0.5	-0.3
Current tobacco smoking	1.1	1.8	4.2	-0.6	-2.1	-0.9
Average weekly fortified wine intake	1.9	2.3	3.5	1.9	1.2	1.3
Maternal smoking around birth	0.6	0.9	2.3	0.4	-1.5	0.4
Fed-up feelings	0.6	1.1	1.8	1.1	-1.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.2	1.1	-0.2	0.8
Relative age voice broke	1.0	1.6	2.4	1.6	1.1	-1.0
Taking other prescription medications	0.3	0.5	1.0	-0.7	0.2	-1.0
Age when periods started (menarche)	0.6	1.4	4.2	2.0	-0.2	-0.1
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.1	-0.2	2.3	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.2	-0.5	-1.5	0.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	0.7	-0.7	-0.7	-0.8
Qualifications: CSEs or equivalent	0.7	0.9	2.5	-0.3	-1.6	0.2
Serious illness, injury or assault to yourself	1.9	2.3	4.2	1.0	1.2	-2.1
High blood pressure	1.3	3.6	8.0	-2.8	-1.2	1.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.4	0.9	0.4
Multivitamins +/- minerals	1.0	1.3	2.0	1.3	1.4	0.3
Stomach or abdominal pain in last month	2.1	2.6	7.7	0.4	2.8	0.0
Supplements: Glucosamine	0.6	0.8	2.2	-0.3	0.1	1.5
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.7	1.5	2.2	-0.4
Medication: Atenolol	0.4	0.5	0.6	-0.7	-0.8	0.7
Medication: Levothyroxine sodium	0.3	0.5	1.4	0.4	-1.2	-0.3
Sitting height	0.1	0.4	0.7	0.8	-0.7	0.4
Chronic bronchitis/emphysema (father)	2.8	3.3	8.1	-1.3	-0.2	2.8
High blood pressure (mother)	0.9	1.3	3.0	0.9	1.7	0.3
Body mass index (BMI)	0.5	2.2	2.9	-1.7	-1.0	1.6
Impedance of leg (left)	0.5	2.5	4.6	2.1	-1.5	-0.9
Leg predicted mass (left)	0.0	0.1	0.1	0.3	-0.0	-0.3
Trunk fat mass	0.2	0.9	2.5	0.1	-1.6	0.3
Waist circumference	0.1	0.3	0.7	0.5	-0.0	0.8
Number of incorrect matches in round	1.8	3.0	4.9	-1.6	-1.2	2.2
Past tobacco smoking	1.2	2.2	4.2	1.5	2.0	-0.2
Alcohol usually taken with meals	4.6	7.5	13.9	2.8	3.7	-0.9
Nervous feelings	0.8	1.5	2.8	1.0	1.7	0.9
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	7.0	2.0	2.6	0.9
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.2	0.4	-0.4
Hair/balding pattern: Pattern 2	1.2	1.6	4.3	0.6	2.1	0.3
Had menopause	0.5	0.6	1.1	0.2	1.0	0.9
Had other major operations	0.7	0.8	1.9	0.1	0.8	1.4
Forced vital capacity (FVC)	1.2	4.4	6.4	1.8	2.5	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.8	0.0	-1.4	0.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	0.9	0.2	0.7
Qualifications: None of the above	2.0	4.3	9.1	-1.8	-3.0	0.8
Financial difficulties in last 2 years	1.8	2.5	5.5	2.3	1.2	0.6
Mouth/teeth dental problems	0.9	1.4	3.2	1.0	1.8	-0.2
Heart attack	0.5	0.6	0.7	0.9	0.8	0.7
Allergy	0.0	0.1	0.2	0.4	-0.1	0.1
Pain all over the body in last month	0.4	0.5	1.0	0.5	0.3	-1.0
Diabetes (self-reported)	0.1	0.2	0.3	0.1	-0.5	-0.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.5	-1.0	-1.6	-0.4
Medication: Ramipril	0.2	0.2	0.4	-0.5	0.6	-0.3
Medication: Simvastatin	0.3	0.5	0.7	-0.7	-0.8	-0.4
Fluid intelligence score	3.8	8.0	13.1	2.3	3.6	-2.4
Illnesses of siblings	2.7	3.8	8.4	2.9	1.7	-0.5
Neuroticism score	0.7	1.4	3.0	1.0	0.4	1.7
Weight	0.1	0.6	1.3	-0.1	-1.1	0.7
Impedance of arm (right)	0.8	3.6	5.9	2.4	1.4	-1.7
Arm fat percentage (right)	0.0	0.2	0.2	-0.5	-0.4	0.3
Trunk fat-free mass	0.1	0.3	0.6	0.8	-0.3	-0.4
Hip circumference	0.3	1.2	2.8	-0.9	-0.4	1.7
Time employed in main current job	0.6	0.6	1.5	-1.2	-0.5	0.4
Alcohol intake versus 10 years previously	0.9	1.3	2.3	-1.1	-0.8	-1.5
Father’s age at death	1.2	1.6	4.1	-0.7	2.0	0.3
Worrier / anxious feelings	0.4	0.7	1.3	0.3	0.8	1.1
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.6	7.6	2.5	2.8	-0.0
Falls in the last year	0.3	0.4	0.8	0.3	0.6	-0.9
Hair/balding pattern: Pattern 3	0.7	1.0	2.4	-0.7	1.5	-0.3
Number of live births	1.1	1.5	2.6	-1.4	-1.6	0.2
Forced expiratory volume in 1-second (FEV1)	2.5	8.5	11.0	3.1	3.3	-2.2
Pulse rate	1.6	2.7	6.2	-0.6	1.3	-2.5
Happiness	1.2	1.5	2.3	1.1	1.0	-1.5
Noisy workplace	1.1	1.4	2.1	-1.4	-1.3	-0.6
Qualifications: A levels/AS levels or equivalent	1.5	3.2	6.6	1.6	2.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	4.2	2.0	1.7	-0.5
Mouth/teeth dental problems: Dentures	1.8	3.1	4.5	-2.1	-2.0	1.0
Asthma	0.2	0.3	0.6	-0.8	0.1	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.8	-1.1	0.3	-1.7
Medication: Cholesterol lowering	0.1	0.1	0.1	-0.4	0.2	-0.3
Depression (self-reported)	2.3	2.8	5.2	1.6	2.3	-0.7
Medication: Lansoprazole	0.7	0.8	1.8	1.3	0.6	0.2
Prospective memory result	4.6	5.6	14.1	-1.4	-3.8	0.8
Lung cancer (father)	2.1	2.4	5.2	-1.3	-2.3	-0.6
Illnesses of mother	0.9	1.1	2.3	-1.1	-1.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.3	13.6	2.7	3.7	-1.9
Pulse wave Arterial Stiffness index	1.2	1.4	2.3	-1.5	-0.5	1.4
Impedance of arm (left)	0.8	3.8	8.1	2.8	1.5	-1.0
Arm fat mass (right)	0.1	0.2	0.4	-0.1	-0.6	0.4
Trunk predicted mass	0.1	0.3	0.7	0.8	-0.3	-0.5
Standing height	0.6	5.6	13.5	3.7	0.0	-1.8
Length of working week for main job	0.5	0.6	1.0	-0.6	1.0	0.6
Exposure to tobacco smoke at home	1.0	1.1	2.3	0.5	-0.9	1.5
Breastfed as a baby	0.5	0.7	1.7	-1.3	0.4	0.2
Tense / ‘highly strung’	0.5	0.8	1.9	-0.7	-0.2	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	4.8	7.3	11.6	3.2	3.4	-0.4
Hair/balding pattern: Pattern 4	1.3	3.2	7.2	-1.3	-2.7	0.8
Birth weight of first child	0.3	0.6	1.3	0.4	0.5	1.1
Peak expiratory flow (PEF)	2.1	5.0	7.1	2.5	2.7	-1.3
Pulse wave reflection index	2.7	3.3	7.4	-1.2	-1.1	2.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	0.5	-0.5	0.3
Loud music exposure frequency	0.3	0.3	0.5	-0.3	-0.7	0.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.1	1.5	1.0	-0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.2	1.5	0.1	-0.5
Blood clot in the leg (DVT)	1.2	1.5	3.0	-0.4	-1.7	-1.2
Medication: Paracetamol	1.9	3.2	5.7	2.4	1.0	-1.7
Headache pain in last month	0.4	0.8	1.8	0.4	1.3	0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.7	1.2	1.3	0.5
Glaucoma (self-reported)	0.5	0.5	1.3	0.0	-1.1	-0.6
Gout (self-reported)	1.8	2.5	6.7	-0.1	-0.9	-2.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	0.7	-1.0	0.4
Medication: Amlodipine	1.6	2.2	5.4	0.1	1.1	-2.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	0.0	-0.2	-1.1
Birth weight	0.2	0.4	0.5	0.7	-0.2	0.7
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.4	0.1	0.4
High blood pressure (siblings)	2.4	3.4	9.8	-3.1	-0.5	0.4
Forced vital capacity (FVC), Best measure	1.9	7.0	11.4	2.1	3.4	-2.3
Body fat percentage	0.2	0.9	1.9	-0.4	-1.4	0.7
Leg fat percentage (right)	0.8	2.8	4.9	-1.3	-2.2	1.4
Arm fat-free mass (right)	0.1	0.4	0.7	0.5	-0.9	0.4
Exposure to tobacco smoke outside home	0.3	0.4	0.7	0.9	0.5	-0.4
Comparative body size at age 10	3.9	10.7	18.2	-3.5	-4.3	1.4
Number of full brothers	0.7	0.9	2.2	0.1	0.7	1.5
Worry too long after embarrassment	1.1	1.9	3.3	1.0	1.8	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.5	1.2	0.1	-0.3
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	-0.5	-0.1	0.1
Number of children fathered	0.2	0.2	0.4	-0.7	-0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	5.1	1.7	2.2	-0.4
Age at first live birth	0.4	0.7	1.4	0.8	1.2	-0.1
Pulse wave peak to peak time	1.6	1.9	3.3	1.8	0.6	-1.4
Health satisfaction	1.2	1.5	4.5	0.3	-0.0	-2.1
Shortness of breath walking on level ground	0.4	0.5	1.2	-1.1	0.1	0.6
Qualifications: College or University degree	1.8	5.6	15.4	0.8	3.9	-0.8
Eye problems/disorders: None of the above	0.5	0.6	1.1	0.7	1.1	0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	-0.2	0.1	-0.9
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.4	0.3	0.1
Medication for pain relief, constipation, heartburn	0.5	0.9	1.3	-1.2	-0.8	0.9
Neck or shoulder pain in last month	1.6	2.3	4.8	1.3	0.8	-2.2
Medication: Blood pressure	0.9	1.6	2.2	-0.8	-1.5	-1.3
Angina (self-reported)	1.4	1.8	3.7	-0.8	-1.9	1.0
Migraine (self-reported)	0.8	1.0	1.5	0.7	1.2	-1.0
Medication: Ibuprofen	0.9	1.1	2.0	-0.3	1.0	-1.4
Medication: Allopurinol	1.3	1.7	4.6	-0.6	-0.4	-2.1
Medication: Omeprazole	0.4	0.5	1.4	0.4	1.2	-0.0
Medication: Seretide 50 evohaler	1.2	1.4	3.0	-1.0	-1.7	-0.3
Mean time to correctly identify matches	0.7	1.2	2.2	-1.5	-0.5	1.2
Heart disease (mother)	0.8	0.9	2.0	-0.2	1.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.3	-0.1	-0.0
Whole body fat mass	0.2	0.9	2.3	-0.3	-1.5	0.6
Leg fat mass (right)	0.4	1.6	3.1	-0.9	-1.8	0.9
Arm predicted mass (right)	0.1	0.4	1.0	0.3	-1.0	0.3
Pulse rate, automated reading	0.2	0.6	0.7	-0.8	-0.6	-0.8
Alcohol intake frequency.	0.5	1.2	2.6	-0.7	-0.8	1.6
Comparative height size at age 10	0.1	0.4	1.0	-0.2	-1.0	0.3
Number of full sisters	0.5	0.7	1.9	-0.3	1.4	-0.0
Suffer from ‘nerves’	0.2	0.3	0.6	0.6	-0.8	-0.1
Overall health rating	0.3	0.5	0.6	0.7	0.8	-0.7
Chest pain or discomfort	3.8	5.4	13.1	1.7	3.6	-0.5
Had major operations	0.7	0.8	1.2	1.1	0.9	-0.6
Age at last live birth	0.4	0.6	0.9	0.9	0.9	-0.1
Family relationship satisfaction	0.1	0.1	0.1	0.3	-0.3	0.3
Leg pain on walking	0.5	0.6	1.0	-1.0	-0.2	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.6	0.9	-1.9	-0.6
Commuting to job workplace: Car/motor vehicle	2.1	2.4	5.9	-1.1	-2.4	-0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	-0.0	-0.9	0.2
Medication: Aspirin	0.7	0.9	2.6	-0.2	0.1	1.6
Supplements: Vitamin C	2.4	2.9	5.4	0.9	2.3	1.6
Knee pain experienced in last month	1.8	2.8	7.3	1.1	2.7	0.1
Hypertension (Self-reported)	1.2	3.3	8.0	-2.8	-1.2	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.0	1.0	-0.1	0.8
Illnesses of father: Heart disease	1.2	1.6	3.0	-1.3	0.4	1.7
Illnesses of siblings: Diabetes	4.1	5.0	6.7	-2.3	-2.6	1.7
Smoking status: Previous	1.6	2.4	4.8	-1.2	-2.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	7.2	2.7	-0.2	-2.6
Whole body fat-free mass	0.0	0.2	0.4	0.7	-0.2	-0.3
Leg fat-free mass (right)	0.0	0.2	0.3	0.5	0.1	-0.4
Arm fat percentage (left)	0.1	0.2	0.5	-0.3	-0.3	0.7
Average weekly red wine intake	0.9	1.3	2.0	1.4	1.4	-0.1
Handedness (chirality/laterality): Left-handed	1.8	2.1	4.1	2.0	1.4	-0.6
Mood swings	0.2	0.4	1.3	1.1	0.1	0.3
Loneliness, isolation	2.5	3.5	6.7	1.4	-1.4	2.6
Long-standing illness, disability or infirmity	0.6	0.9	1.5	-1.2	0.6	-0.9
Ever had bowel cancer screening	0.2	0.2	0.4	-0.6	-0.0	-0.6
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.2	-0.6	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	5.5	-0.7	-0.1	2.4
Friendships satisfaction	0.2	0.2	0.4	0.4	-0.6	0.2
Qualifications: nursing, teaching	0.9	1.4	4.1	-2.0	-0.4	-0.1
Commuting to job workplace: Walk	2.7	2.9	7.0	0.9	2.6	-0.9
Eye problems/disorders: Cataract	0.5	0.5	0.7	0.8	0.9	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	5.4	-1.6	-2.3	-0.1
Medication for cholesterol	0.3	0.4	0.8	0.9	-0.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.3	-0.1	-1.5	0.9
Back pain experienced in last month	1.6	2.4	3.7	0.8	-1.9	1.7
Mineral and other dietary supplements	0.7	1.0	1.6	-0.1	-1.1	-1.3
Breast cancer (self-reported)	0.2	0.3	0.4	-0.6	0.4	0.6
Asthma (self-reported)	0.4	0.8	1.4	-1.2	-0.2	0.9
Osteoporosis (self-reported)	0.2	0.3	0.6	0.3	-0.8	-0.2
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.1	0.7	1.0
Medication: Aspirin	1.2	1.6	4.7	-0.0	-0.2	2.2
Medication: Gliclazide	0.2	0.2	0.6	0.1	0.8	-0.3
Illnesses of father: None of the above (group 1)	1.9	2.4	2.5	1.5	1.6	-1.5
Smoking status: Current	1.3	2.1	4.6	-0.5	-2.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.4	4.3	1.4	2.1	-0.9
Whole body water mass	0.0	0.1	0.3	0.5	-0.2	-0.3
Leg predicted mass (right)	0.0	0.2	0.4	0.6	0.1	-0.5
Arm fat mass (left)	0.1	0.5	0.9	-0.3	-1.0	0.8
Number of self-reported non-cancer illnesses	0.3	0.6	0.9	-0.9	1.0	0.0
Average weekly champagne plus white wine intake	0.4	0.6	1.3	-0.6	-0.2	1.1
Miserableness	0.7	1.2	3.2	1.8	0.5	-0.4
Guilty feelings	0.7	1.1	1.9	1.1	1.4	0.5
Wears glasses or contact lenses	0.8	0.9	2.0	0.6	1.4	-0.5
Ever taken oral contraceptive pill	0.7	0.7	1.5	1.2	0.3	-0.8
Hearing aid user	0.8	0.9	1.8	0.4	-0.8	-1.3
Mother’s age at death	0.5	0.6	0.9	0.3	0.9	-0.9
Financial situation satisfaction	0.7	0.9	1.1	0.9	1.1	-0.9
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.1	1.5	1.0	-0.6
Commuting to job workplace: Public transport	6.8	8.1	14.9	2.9	3.9	-0.9
Eye problems/disorders: Glaucoma	0.8	1.0	1.7	-0.6	-1.3	-0.9
Medication: Blood pressure	0.7	1.4	2.3	-1.5	-0.2	1.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.2	-1.0	0.3
Supplements: Fish oil (including cod liver oil)	0.9	1.1	3.2	-0.4	1.8	0.0
High cholesterol (Self-reported)	0.2	0.3	0.9	0.3	0.1	-1.0
Medication: Bendroflumethiazide	0.6	0.9	1.7	-1.3	-0.8	0.6
Medication: Paracetamol	2.7	4.2	10.4	3.2	0.9	-1.1
Medication: Lisinopril	0.1	0.1	0.2	-0.1	-0.5	0.2
Medication: Atorvastatin	0.0	0.0	0.1	0.2	0.2	-0.2
Illnesses of father: High blood pressure	1.0	1.3	3.5	-0.5	-1.9	0.3
Alcohol drinker status: Never	3.5	4.2	7.2	2.7	2.3	0.4
Ever smoked	1.1	1.9	2.8	-1.7	-1.7	-0.1
Basal metabolic rate	0.0	0.2	0.5	0.7	-0.4	-0.2
Leg fat percentage (left)	1.0	3.6	6.6	-1.4	-2.6	1.4
Arm fat-free mass (left)	0.1	0.4	0.9	0.5	-0.9	-0.2
Number of operations (self-reported)	0.1	0.2	0.4	0.6	0.1	0.3
Average weekly beer plus cider intake	0.8	1.1	1.8	0.2	-1.2	-1.4
Irritability	0.8	1.4	3.8	-0.2	-1.9	-0.5
Risk taking	0.1	0.1	0.4	0.2	-0.1	0.6
Ever had prostate specific antigen (PSA) test	0.7	0.9	2.4	-1.5	-0.0	0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.5	0.1	-0.7	0.5
Age started oral contraceptive pill	0.7	0.9	2.6	-1.6	-0.2	-0.1
Diastolic blood pressure, automated reading	0.6	1.7	3.8	-1.1	-2.0	0.4
Ever depressed for a whole week	0.3	0.4	0.6	0.7	0.8	-0.1
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.8	-0.3	-0.1
Commuting to job workplace: Cycle	0.2	0.3	0.6	-0.1	0.8	0.5
Myopia	1.2	1.8	2.7	-1.0	1.3	1.7
Vascular/heart problems diagnosed by doctor	1.3	3.7	7.6	2.8	1.1	-1.5
Cholesterol lowering medication	0.8	1.2	2.4	-1.6	-0.5	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.8	0.4	0.9	-0.6
Pain experienced in last month	0.4	0.6	1.0	-1.0	-0.6	0.7
Supplements: Calcium	1.3	1.4	2.5	1.6	1.4	-0.0
Basal cell carcinoma (self-reported)	0.5	0.5	1.4	-0.0	0.5	-1.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.3	1.1	1.0	0.6
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.3	-0.5	-1.8	-1.5
Heart disease (siblings)	0.2	0.2	0.6	-0.7	0.1	-0.3
Alcohol drinker status: Previous	0.8	0.9	2.1	0.8	-0.3	1.4
Pack years of smoking	0.8	1.2	1.9	0.9	-0.9	-1.4
Impedance of whole body	0.7	3.7	9.1	3.0	0.3	-1.4
Leg fat mass (left)	0.5	1.9	3.9	-1.0	-2.0	0.9
Arm predicted mass (left)	0.1	0.4	1.1	0.4	-1.0	0.1