Hub : Genes

MEX3B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.180 0.0550 2.1e-05 0.123 NA 0.133 NA 0.150 2.9e-07 NA 8.7e-08 NA 1.2e-08
2 GTEx Cells Transformed fibroblasts 0.184 0.0460 6.0e-07 0.115 NA 0.105 NA 0.104 6.0e-09 NA 3.0e-08 NA 3.2e-08
3 GTEx Lung 0.101 0.0364 4.7e-04 -0.003 NA 0.000 NA -0.001 7.4e-01 NA 3.3e-01 NA 3.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.9 3.0 4.4 -1.5 -1.6 2.1
Bipolar Disorder or Schizophrenia 3.3 8.1 10.2 -2.1 -3.1 3.2
Depressed Affect (Nagel 2018) 0.8 1.7 4.3 2.1 -0.8 0.3
Depression (Nagel 2018) 0.9 1.3 1.9 0.7 -1.3 1.4
Intelligence (Savage-Jansen 2018) 5.1 15.8 29.7 4.1 5.4 -1.0
Neuroticism (Nagel 2018) 0.5 1.1 2.7 1.6 -0.3 0.7
Schizophrenia (2018) 2.5 5.2 7.5 -1.5 -2.7 2.4
Schizophrenia vs Biploar Disorder 1.2 1.6 4.7 -0.1 0.1 2.2
Worry (Nagel 2018) 0.2 0.5 1.0 1.0 -0.1 0.7
Alzheimer’s Disease (in mother) 0.5 0.6 1.7 1.3 -0.5 -0.0
Alzheimer’s Disease (in father) 0.2 0.2 0.5 0.3 -0.7 0.2
Alzheimer’s Disease (including proxy) 0.4 0.6 1.4 0.6 -1.2 -0.2
Crohns Disease (2017) 0.4 1.0 2.2 -1.5 -0.6 0.6
Irritable Bowel Disease (IBD) 0.4 1.0 2.5 -1.6 -0.7 0.3
Ulcerative Colitis (UC) 0.7 1.2 2.6 -1.6 -0.4 1.0
Major Depression (MDD) 0.5 0.6 0.9 0.8 1.0 -0.5
Reaction Time 0.0 0.1 0.1 -0.2 0.2 0.3
Verbal and Numeric Reasoning (VNR) 3.1 7.4 10.1 2.6 3.2 -2.3
Breast Cancer 0.6 1.3 2.9 0.2 -1.0 -1.7
Ovarian Cancer 0.7 1.0 2.2 -0.5 -1.5 -0.7
Prostate Cancer 1.0 1.4 3.6 0.7 0.3 -1.9
Age at First Birth 0.9 1.3 2.8 1.0 0.1 1.7
Bipolar Disorder (2011) 0.3 0.3 0.4 -0.4 -0.5 0.7
Body Mass Index (BMI) (2010) 2.6 3.6 10.4 -3.2 -0.2 0.7
Coronary Artery Disease (CAD) 1.5 1.8 4.5 2.1 -0.9 0.0
Crohns Disease (2012) 0.5 0.8 1.3 -1.1 -1.0 0.5
Mean Putamen Volume 0.3 0.4 0.7 0.7 -0.8 0.2
Fasting Glucose 2.3 2.7 4.1 -1.9 0.5 2.0
HbA1C 1.4 1.6 2.6 1.3 0.7 -1.6
HDL Cholesterol 0.2 0.4 0.8 0.9 -0.4 0.5
LDL Cholesterol 0.5 0.7 1.6 0.5 0.6 1.3
Lupus 0.2 0.3 0.5 -0.7 -0.7 -0.1
Neuroticism (2016) 0.5 0.8 1.4 1.0 1.2 0.1
Primary Biliary Cirrhosis 0.2 0.3 0.4 -0.6 -0.6 0.3
Rheumatoid Arthritis 0.1 0.2 0.4 0.4 -0.7 -0.0
Schizophrenia (2014) 1.9 4.3 9.0 -0.8 -1.8 3.0
Triglycerides 0.3 0.5 0.9 0.3 0.8 -1.0
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.5 0.2 -0.6 0.7
Ulcerative Colitis 0.3 0.5 0.8 -0.9 -0.8 0.3
Blood Eosinophil Count 0.2 1.2 2.2 0.1 -1.5 1.2
Blood Platelet Count 0.0 0.1 0.2 -0.5 0.3 0.2
Blood Red Count 1.5 14.1 25.5 4.1 5.0 -0.3
Blood White Count 0.0 0.1 0.1 0.4 0.1 -0.3
Heel T-Score 0.0 0.2 0.3 -0.1 0.5 -0.4
BMI 0.2 1.4 2.2 -1.5 -0.2 1.4
Height 0.4 8.2 19.9 4.5 -0.6 -2.1
Waist Hip Ratio (WHR) 2.6 11.9 22.8 4.8 2.5 -2.6
Systolic Blood Pressure 0.2 1.0 2.7 0.6 0.1 -1.6
Smoking Status 1.4 3.4 8.9 -1.1 -3.0 0.0
Allergy or Eczema 0.1 0.2 0.5 -0.4 0.2 0.7
Cardiovascular Disease 0.2 0.7 1.6 -1.3 -0.5 -0.5
Hypothyroidism (self reported) 0.5 1.1 1.8 1.4 -1.2 -0.2
Respiratory disease 0.2 0.3 0.6 -0.2 0.8 0.6
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 0.3 -0.3 -0.6
Lung FEV1/FVC ratio 0.5 2.7 7.1 2.7 0.6 -0.7
Lung FVC 0.9 4.6 12.0 -1.3 3.5 -0.4
Neuroticism 0.5 1.2 2.3 1.1 0.3 1.5
Chronotype (morning person) 0.8 1.9 4.5 0.7 0.9 2.1
Hair Pigment 0.5 13.4 30.2 2.3 5.5 -2.1
Tanning 1.3 15.8 23.9 -4.5 -4.9 1.9
Hand grip strength (left) 0.3 0.7 1.4 0.7 -1.2 -0.5
Number of treatments/medications taken 0.1 0.1 0.3 0.1 0.5 -0.3
Average weekly spirits intake 0.9 1.1 1.4 -1.2 -0.8 1.1
Sensitivity / hurt feelings 4.0 6.9 19.2 -0.7 -0.9 4.4
Frequency of depressed mood in last 2 weeks 1.3 1.8 3.3 1.8 -0.4 1.4
Hearing difficulty/problems: Yes 0.1 0.1 0.2 0.4 -0.1 0.4
Relative age of first facial hair 1.0 2.0 4.1 1.2 2.0 -0.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.6 -0.7 0.3 -0.8
Ever used hormone-replacement therapy (HRT) 0.5 0.7 2.0 -0.1 1.4 0.3
Ever had hysterectomy (womb removed) 0.3 0.3 0.4 0.5 0.6 0.5
Systolic blood pressure, automated reading 0.2 0.5 1.3 -0.4 -0.2 -1.2
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.8 -0.3 -0.6 -0.9
Angina 1.4 1.9 3.3 -0.8 -1.8 1.3
Medication for hormone replacement therapy 1.2 1.4 1.9 1.1 1.0 -1.4
Vitamin and mineral supplements 2.5 3.4 6.2 -1.9 -2.5 -0.7
Supplements: Zinc 1.2 1.3 2.3 1.5 1.3 -0.1
Medication: Co-codamol 1.6 1.8 4.9 -0.7 -2.2 0.4
Medication: Metformin 0.8 1.1 3.2 0.0 0.1 -1.8
Diabetes (father) 2.6 3.3 3.7 -1.8 -1.9 1.7
Diabetes (mother) 0.9 1.2 2.6 1.0 1.6 0.1
Severe depression (siblings) 1.5 1.6 3.7 -0.3 1.1 -1.9
Pack years adult smoking proportion 1.1 1.6 2.5 1.4 -0.6 -1.6
Impedance of leg (right) 0.4 2.1 4.8 2.2 -1.0 -0.7
Leg fat-free mass (left) 0.0 0.1 0.2 0.4 0.1 -0.4
Trunk fat percentage 0.2 0.7 1.8 0.0 -1.3 0.4
Hand grip strength (right) 0.6 1.7 2.6 1.5 -0.6 -1.6
Townsend deprivation index at recruitment 0.1 0.2 0.3 0.5 0.5 -0.3
Current tobacco smoking 1.1 1.8 4.2 -0.6 -2.1 -0.9
Average weekly fortified wine intake 1.9 2.3 3.5 1.9 1.2 1.3
Maternal smoking around birth 0.6 0.9 2.3 0.4 -1.5 0.4
Fed-up feelings 0.6 1.1 1.8 1.1 -1.3 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.2 1.1 -0.2 0.8
Relative age voice broke 1.0 1.6 2.4 1.6 1.1 -1.0
Taking other prescription medications 0.3 0.5 1.0 -0.7 0.2 -1.0
Age when periods started (menarche) 0.6 1.4 4.2 2.0 -0.2 -0.1
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 5.1 -0.2 2.3 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.2 -0.5 -1.5 0.2
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 0.7 -0.7 -0.7 -0.8
Qualifications: CSEs or equivalent 0.7 0.9 2.5 -0.3 -1.6 0.2
Serious illness, injury or assault to yourself 1.9 2.3 4.2 1.0 1.2 -2.1
High blood pressure 1.3 3.6 8.0 -2.8 -1.2 1.1
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.8 0.4 0.9 0.4
Multivitamins +/- minerals 1.0 1.3 2.0 1.3 1.4 0.3
Stomach or abdominal pain in last month 2.1 2.6 7.7 0.4 2.8 0.0
Supplements: Glucosamine 0.6 0.8 2.2 -0.3 0.1 1.5
Diverticular disease/diverticulitis (self-reported) 2.0 2.4 4.7 1.5 2.2 -0.4
Medication: Atenolol 0.4 0.5 0.6 -0.7 -0.8 0.7
Medication: Levothyroxine sodium 0.3 0.5 1.4 0.4 -1.2 -0.3
Sitting height 0.1 0.4 0.7 0.8 -0.7 0.4
Chronic bronchitis/emphysema (father) 2.8 3.3 8.1 -1.3 -0.2 2.8
High blood pressure (mother) 0.9 1.3 3.0 0.9 1.7 0.3
Body mass index (BMI) 0.5 2.2 2.9 -1.7 -1.0 1.6
Impedance of leg (left) 0.5 2.5 4.6 2.1 -1.5 -0.9
Leg predicted mass (left) 0.0 0.1 0.1 0.3 -0.0 -0.3
Trunk fat mass 0.2 0.9 2.5 0.1 -1.6 0.3
Waist circumference 0.1 0.3 0.7 0.5 -0.0 0.8
Number of incorrect matches in round 1.8 3.0 4.9 -1.6 -1.2 2.2
Past tobacco smoking 1.2 2.2 4.2 1.5 2.0 -0.2
Alcohol usually taken with meals 4.6 7.5 13.9 2.8 3.7 -0.9
Nervous feelings 0.8 1.5 2.8 1.0 1.7 0.9
Frequency of tenseness / restlessness in last 2 weeks 2.6 4.0 7.0 2.0 2.6 0.9
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.2 0.4 -0.4
Hair/balding pattern: Pattern 2 1.2 1.6 4.3 0.6 2.1 0.3
Had menopause 0.5 0.6 1.1 0.2 1.0 0.9
Had other major operations 0.7 0.8 1.9 0.1 0.8 1.4
Forced vital capacity (FVC) 1.2 4.4 6.4 1.8 2.5 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.8 0.0 -1.4 0.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.9 0.9 0.2 0.7
Qualifications: None of the above 2.0 4.3 9.1 -1.8 -3.0 0.8
Financial difficulties in last 2 years 1.8 2.5 5.5 2.3 1.2 0.6
Mouth/teeth dental problems 0.9 1.4 3.2 1.0 1.8 -0.2
Heart attack 0.5 0.6 0.7 0.9 0.8 0.7
Allergy 0.0 0.1 0.2 0.4 -0.1 0.1
Pain all over the body in last month 0.4 0.5 1.0 0.5 0.3 -1.0
Diabetes (self-reported) 0.1 0.2 0.3 0.1 -0.5 -0.5
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.5 -1.0 -1.6 -0.4
Medication: Ramipril 0.2 0.2 0.4 -0.5 0.6 -0.3
Medication: Simvastatin 0.3 0.5 0.7 -0.7 -0.8 -0.4
Fluid intelligence score 3.8 8.0 13.1 2.3 3.6 -2.4
Illnesses of siblings 2.7 3.8 8.4 2.9 1.7 -0.5
Neuroticism score 0.7 1.4 3.0 1.0 0.4 1.7
Weight 0.1 0.6 1.3 -0.1 -1.1 0.7
Impedance of arm (right) 0.8 3.6 5.9 2.4 1.4 -1.7
Arm fat percentage (right) 0.0 0.2 0.2 -0.5 -0.4 0.3
Trunk fat-free mass 0.1 0.3 0.6 0.8 -0.3 -0.4
Hip circumference 0.3 1.2 2.8 -0.9 -0.4 1.7
Time employed in main current job 0.6 0.6 1.5 -1.2 -0.5 0.4
Alcohol intake versus 10 years previously 0.9 1.3 2.3 -1.1 -0.8 -1.5
Father’s age at death 1.2 1.6 4.1 -0.7 2.0 0.3
Worrier / anxious feelings 0.4 0.7 1.3 0.3 0.8 1.1
Frequency of tiredness / lethargy in last 2 weeks 2.8 4.6 7.6 2.5 2.8 -0.0
Falls in the last year 0.3 0.4 0.8 0.3 0.6 -0.9
Hair/balding pattern: Pattern 3 0.7 1.0 2.4 -0.7 1.5 -0.3
Number of live births 1.1 1.5 2.6 -1.4 -1.6 0.2
Forced expiratory volume in 1-second (FEV1) 2.5 8.5 11.0 3.1 3.3 -2.2
Pulse rate 1.6 2.7 6.2 -0.6 1.3 -2.5
Happiness 1.2 1.5 2.3 1.1 1.0 -1.5
Noisy workplace 1.1 1.4 2.1 -1.4 -1.3 -0.6
Qualifications: A levels/AS levels or equivalent 1.5 3.2 6.6 1.6 2.6 -0.8
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 4.2 2.0 1.7 -0.5
Mouth/teeth dental problems: Dentures 1.8 3.1 4.5 -2.1 -2.0 1.0
Asthma 0.2 0.3 0.6 -0.8 0.1 0.6
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.8 -1.1 0.3 -1.7
Medication: Cholesterol lowering 0.1 0.1 0.1 -0.4 0.2 -0.3
Depression (self-reported) 2.3 2.8 5.2 1.6 2.3 -0.7
Medication: Lansoprazole 0.7 0.8 1.8 1.3 0.6 0.2
Prospective memory result 4.6 5.6 14.1 -1.4 -3.8 0.8
Lung cancer (father) 2.1 2.4 5.2 -1.3 -2.3 -0.6
Illnesses of mother 0.9 1.1 2.3 -1.1 -1.5 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.6 8.3 13.6 2.7 3.7 -1.9
Pulse wave Arterial Stiffness index 1.2 1.4 2.3 -1.5 -0.5 1.4
Impedance of arm (left) 0.8 3.8 8.1 2.8 1.5 -1.0
Arm fat mass (right) 0.1 0.2 0.4 -0.1 -0.6 0.4
Trunk predicted mass 0.1 0.3 0.7 0.8 -0.3 -0.5
Standing height 0.6 5.6 13.5 3.7 0.0 -1.8
Length of working week for main job 0.5 0.6 1.0 -0.6 1.0 0.6
Exposure to tobacco smoke at home 1.0 1.1 2.3 0.5 -0.9 1.5
Breastfed as a baby 0.5 0.7 1.7 -1.3 0.4 0.2
Tense / ‘highly strung’ 0.5 0.8 1.9 -0.7 -0.2 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 4.8 7.3 11.6 3.2 3.4 -0.4
Hair/balding pattern: Pattern 4 1.3 3.2 7.2 -1.3 -2.7 0.8
Birth weight of first child 0.3 0.6 1.3 0.4 0.5 1.1
Peak expiratory flow (PEF) 2.1 5.0 7.1 2.5 2.7 -1.3
Pulse wave reflection index 2.7 3.3 7.4 -1.2 -1.1 2.7
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.3 0.5 -0.5 0.3
Loud music exposure frequency 0.3 0.3 0.5 -0.3 -0.7 0.6
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.1 1.5 1.0 -0.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.2 1.5 0.1 -0.5
Blood clot in the leg (DVT) 1.2 1.5 3.0 -0.4 -1.7 -1.2
Medication: Paracetamol 1.9 3.2 5.7 2.4 1.0 -1.7
Headache pain in last month 0.4 0.8 1.8 0.4 1.3 0.6
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 1.7 1.2 1.3 0.5
Glaucoma (self-reported) 0.5 0.5 1.3 0.0 -1.1 -0.6
Gout (self-reported) 1.8 2.5 6.7 -0.1 -0.9 -2.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.1 0.7 -1.0 0.4
Medication: Amlodipine 1.6 2.2 5.4 0.1 1.1 -2.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.1 0.0 -0.2 -1.1
Birth weight 0.2 0.4 0.5 0.7 -0.2 0.7
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 0.4 0.1 0.4
High blood pressure (siblings) 2.4 3.4 9.8 -3.1 -0.5 0.4
Forced vital capacity (FVC), Best measure 1.9 7.0 11.4 2.1 3.4 -2.3
Body fat percentage 0.2 0.9 1.9 -0.4 -1.4 0.7
Leg fat percentage (right) 0.8 2.8 4.9 -1.3 -2.2 1.4
Arm fat-free mass (right) 0.1 0.4 0.7 0.5 -0.9 0.4
Exposure to tobacco smoke outside home 0.3 0.4 0.7 0.9 0.5 -0.4
Comparative body size at age 10 3.9 10.7 18.2 -3.5 -4.3 1.4
Number of full brothers 0.7 0.9 2.2 0.1 0.7 1.5
Worry too long after embarrassment 1.1 1.9 3.3 1.0 1.8 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.5 1.2 0.1 -0.3
Wheeze or whistling in the chest in last year 0.1 0.1 0.3 -0.5 -0.1 0.1
Number of children fathered 0.2 0.2 0.4 -0.7 -0.4 0.2
Reason for reducing amount of alcohol drunk: Health precaution 2.3 2.7 5.1 1.7 2.2 -0.4
Age at first live birth 0.4 0.7 1.4 0.8 1.2 -0.1
Pulse wave peak to peak time 1.6 1.9 3.3 1.8 0.6 -1.4
Health satisfaction 1.2 1.5 4.5 0.3 -0.0 -2.1
Shortness of breath walking on level ground 0.4 0.5 1.2 -1.1 0.1 0.6
Qualifications: College or University degree 1.8 5.6 15.4 0.8 3.9 -0.8
Eye problems/disorders: None of the above 0.5 0.6 1.1 0.7 1.1 0.1
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.9 -0.2 0.1 -0.9
Emphysema/chronic bronchitis 0.1 0.1 0.1 -0.4 0.3 0.1
Medication for pain relief, constipation, heartburn 0.5 0.9 1.3 -1.2 -0.8 0.9
Neck or shoulder pain in last month 1.6 2.3 4.8 1.3 0.8 -2.2
Medication: Blood pressure 0.9 1.6 2.2 -0.8 -1.5 -1.3
Angina (self-reported) 1.4 1.8 3.7 -0.8 -1.9 1.0
Migraine (self-reported) 0.8 1.0 1.5 0.7 1.2 -1.0
Medication: Ibuprofen 0.9 1.1 2.0 -0.3 1.0 -1.4
Medication: Allopurinol 1.3 1.7 4.6 -0.6 -0.4 -2.1
Medication: Omeprazole 0.4 0.5 1.4 0.4 1.2 -0.0
Medication: Seretide 50 evohaler 1.2 1.4 3.0 -1.0 -1.7 -0.3
Mean time to correctly identify matches 0.7 1.2 2.2 -1.5 -0.5 1.2
Heart disease (mother) 0.8 0.9 2.0 -0.2 1.4 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.1 0.3 -0.1 -0.0
Whole body fat mass 0.2 0.9 2.3 -0.3 -1.5 0.6
Leg fat mass (right) 0.4 1.6 3.1 -0.9 -1.8 0.9
Arm predicted mass (right) 0.1 0.4 1.0 0.3 -1.0 0.3
Pulse rate, automated reading 0.2 0.6 0.7 -0.8 -0.6 -0.8
Alcohol intake frequency. 0.5 1.2 2.6 -0.7 -0.8 1.6
Comparative height size at age 10 0.1 0.4 1.0 -0.2 -1.0 0.3
Number of full sisters 0.5 0.7 1.9 -0.3 1.4 -0.0
Suffer from ‘nerves’ 0.2 0.3 0.6 0.6 -0.8 -0.1
Overall health rating 0.3 0.5 0.6 0.7 0.8 -0.7
Chest pain or discomfort 3.8 5.4 13.1 1.7 3.6 -0.5
Had major operations 0.7 0.8 1.2 1.1 0.9 -0.6
Age at last live birth 0.4 0.6 0.9 0.9 0.9 -0.1
Family relationship satisfaction 0.1 0.1 0.1 0.3 -0.3 0.3
Leg pain on walking 0.5 0.6 1.0 -1.0 -0.2 -0.9
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 3.6 0.9 -1.9 -0.6
Commuting to job workplace: Car/motor vehicle 2.1 2.4 5.9 -1.1 -2.4 -0.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.8 -0.0 -0.9 0.2
Medication: Aspirin 0.7 0.9 2.6 -0.2 0.1 1.6
Supplements: Vitamin C 2.4 2.9 5.4 0.9 2.3 1.6
Knee pain experienced in last month 1.8 2.8 7.3 1.1 2.7 0.1
Hypertension (Self-reported) 1.2 3.3 8.0 -2.8 -1.2 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.0 1.0 -0.1 0.8
Illnesses of father: Heart disease 1.2 1.6 3.0 -1.3 0.4 1.7
Illnesses of siblings: Diabetes 4.1 5.0 6.7 -2.3 -2.6 1.7
Smoking status: Previous 1.6 2.4 4.8 -1.2 -2.2 0.9
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.6 7.2 2.7 -0.2 -2.6
Whole body fat-free mass 0.0 0.2 0.4 0.7 -0.2 -0.3
Leg fat-free mass (right) 0.0 0.2 0.3 0.5 0.1 -0.4
Arm fat percentage (left) 0.1 0.2 0.5 -0.3 -0.3 0.7
Average weekly red wine intake 0.9 1.3 2.0 1.4 1.4 -0.1
Handedness (chirality/laterality): Left-handed 1.8 2.1 4.1 2.0 1.4 -0.6
Mood swings 0.2 0.4 1.3 1.1 0.1 0.3
Loneliness, isolation 2.5 3.5 6.7 1.4 -1.4 2.6
Long-standing illness, disability or infirmity 0.6 0.9 1.5 -1.2 0.6 -0.9
Ever had bowel cancer screening 0.2 0.2 0.4 -0.6 -0.0 -0.6
Diabetes diagnosed by doctor 0.1 0.2 0.4 -0.2 -0.6 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 5.5 -0.7 -0.1 2.4
Friendships satisfaction 0.2 0.2 0.4 0.4 -0.6 0.2
Qualifications: nursing, teaching 0.9 1.4 4.1 -2.0 -0.4 -0.1
Commuting to job workplace: Walk 2.7 2.9 7.0 0.9 2.6 -0.9
Eye problems/disorders: Cataract 0.5 0.5 0.7 0.8 0.9 -0.5
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 5.4 -1.6 -2.3 -0.1
Medication for cholesterol 0.3 0.4 0.8 0.9 -0.2 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.3 -0.1 -1.5 0.9
Back pain experienced in last month 1.6 2.4 3.7 0.8 -1.9 1.7
Mineral and other dietary supplements 0.7 1.0 1.6 -0.1 -1.1 -1.3
Breast cancer (self-reported) 0.2 0.3 0.4 -0.6 0.4 0.6
Asthma (self-reported) 0.4 0.8 1.4 -1.2 -0.2 0.9
Osteoporosis (self-reported) 0.2 0.3 0.6 0.3 -0.8 -0.2
Osteoarthritis (self-reported) 0.4 0.5 1.0 0.1 0.7 1.0
Medication: Aspirin 1.2 1.6 4.7 -0.0 -0.2 2.2
Medication: Gliclazide 0.2 0.2 0.6 0.1 0.8 -0.3
Illnesses of father: None of the above (group 1) 1.9 2.4 2.5 1.5 1.6 -1.5
Smoking status: Current 1.3 2.1 4.6 -0.5 -2.1 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.4 4.3 1.4 2.1 -0.9
Whole body water mass 0.0 0.1 0.3 0.5 -0.2 -0.3
Leg predicted mass (right) 0.0 0.2 0.4 0.6 0.1 -0.5
Arm fat mass (left) 0.1 0.5 0.9 -0.3 -1.0 0.8
Number of self-reported non-cancer illnesses 0.3 0.6 0.9 -0.9 1.0 0.0
Average weekly champagne plus white wine intake 0.4 0.6 1.3 -0.6 -0.2 1.1
Miserableness 0.7 1.2 3.2 1.8 0.5 -0.4
Guilty feelings 0.7 1.1 1.9 1.1 1.4 0.5
Wears glasses or contact lenses 0.8 0.9 2.0 0.6 1.4 -0.5
Ever taken oral contraceptive pill 0.7 0.7 1.5 1.2 0.3 -0.8
Hearing aid user 0.8 0.9 1.8 0.4 -0.8 -1.3
Mother’s age at death 0.5 0.6 0.9 0.3 0.9 -0.9
Financial situation satisfaction 0.7 0.9 1.1 0.9 1.1 -0.9
Tinnitus: Yes, now most or all of the time 1.0 1.1 2.1 1.5 1.0 -0.6
Commuting to job workplace: Public transport 6.8 8.1 14.9 2.9 3.9 -0.9
Eye problems/disorders: Glaucoma 0.8 1.0 1.7 -0.6 -1.3 -0.9
Medication: Blood pressure 0.7 1.4 2.3 -1.5 -0.2 1.3
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.1 -0.2 -1.0 0.3
Supplements: Fish oil (including cod liver oil) 0.9 1.1 3.2 -0.4 1.8 0.0
High cholesterol (Self-reported) 0.2 0.3 0.9 0.3 0.1 -1.0
Medication: Bendroflumethiazide 0.6 0.9 1.7 -1.3 -0.8 0.6
Medication: Paracetamol 2.7 4.2 10.4 3.2 0.9 -1.1
Medication: Lisinopril 0.1 0.1 0.2 -0.1 -0.5 0.2
Medication: Atorvastatin 0.0 0.0 0.1 0.2 0.2 -0.2
Illnesses of father: High blood pressure 1.0 1.3 3.5 -0.5 -1.9 0.3
Alcohol drinker status: Never 3.5 4.2 7.2 2.7 2.3 0.4
Ever smoked 1.1 1.9 2.8 -1.7 -1.7 -0.1
Basal metabolic rate 0.0 0.2 0.5 0.7 -0.4 -0.2
Leg fat percentage (left) 1.0 3.6 6.6 -1.4 -2.6 1.4
Arm fat-free mass (left) 0.1 0.4 0.9 0.5 -0.9 -0.2
Number of operations (self-reported) 0.1 0.2 0.4 0.6 0.1 0.3
Average weekly beer plus cider intake 0.8 1.1 1.8 0.2 -1.2 -1.4
Irritability 0.8 1.4 3.8 -0.2 -1.9 -0.5
Risk taking 0.1 0.1 0.4 0.2 -0.1 0.6
Ever had prostate specific antigen (PSA) test 0.7 0.9 2.4 -1.5 -0.0 0.4
Fractured/broken bones in last 5 years 0.2 0.2 0.5 0.1 -0.7 0.5
Age started oral contraceptive pill 0.7 0.9 2.6 -1.6 -0.2 -0.1
Diastolic blood pressure, automated reading 0.6 1.7 3.8 -1.1 -2.0 0.4
Ever depressed for a whole week 0.3 0.4 0.6 0.7 0.8 -0.1
Unable to work because of sickness or disability 0.2 0.2 0.6 -0.8 -0.3 -0.1
Commuting to job workplace: Cycle 0.2 0.3 0.6 -0.1 0.8 0.5
Myopia 1.2 1.8 2.7 -1.0 1.3 1.7
Vascular/heart problems diagnosed by doctor 1.3 3.7 7.6 2.8 1.1 -1.5
Cholesterol lowering medication 0.8 1.2 2.4 -1.6 -0.5 0.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 0.8 0.4 0.9 -0.6
Pain experienced in last month 0.4 0.6 1.0 -1.0 -0.6 0.7
Supplements: Calcium 1.3 1.4 2.5 1.6 1.4 -0.0
Basal cell carcinoma (self-reported) 0.5 0.5 1.4 -0.0 0.5 -1.2
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.3 1.1 1.0 0.6
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 3.3 -0.5 -1.8 -1.5
Heart disease (siblings) 0.2 0.2 0.6 -0.7 0.1 -0.3
Alcohol drinker status: Previous 0.8 0.9 2.1 0.8 -0.3 1.4
Pack years of smoking 0.8 1.2 1.9 0.9 -0.9 -1.4
Impedance of whole body 0.7 3.7 9.1 3.0 0.3 -1.4
Leg fat mass (left) 0.5 1.9 3.9 -1.0 -2.0 0.9
Arm predicted mass (left) 0.1 0.4 1.1 0.4 -1.0 0.1