Best TWAS P=3.63e-08 · Best GWAS P=4.68e-07 conditioned to 0.422
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C6orf106 | 0.29 | 0.21 | bslmm | 382 | 0.23 | 6.9e-28 | -4.1 | -5.2 | 1.9e-07 | 0.75 | 0.16 | 0.78 | FALSE |
| 2 | GTEx | Brain Cortex | C6orf106 | 0.22 | 0.07 | enet | 16 | 0.10 | 1.1e-03 | -4.2 | -5.4 | 8.1e-08 | 0.59 | 0.06 | 0.84 | FALSE |
| 3 | GTEx | Nerve Tibial | C6orf106 | 0.11 | 0.07 | enet | 17 | 0.07 | 1.3e-05 | -4.0 | -5.5 | 3.6e-08 | 0.83 | 0.05 | 0.90 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf106 | 0.03 | 0.03 | lasso | 3 | 0.01 | 7.6e-03 | -5.0 | -5.4 | 5.2e-08 | 0.97 | 0.00 | 0.94 | FALSE |