TWAS
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About
Usage
Models
Genes
Traits
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Traits
:
LDL Cholesterol
:
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chr6:33,856,903-35,362,848
Best TWAS P=3.63e-08 · Best GWAS P=4.68e-07 conditioned to 0.422
33.8M
34M
34.2M
34.4M
34.6M
34.8M
35M
35.2M
35.4M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Nerve Tibial
C6orf106
0.11
0.07
enet
17
0.07
1.3e-05
-4.0
-5.5
3.6e-08
0.83
0.05
0.90
TRUE
4
The Cancer Genome Atlas
Lung Adenocarcinoma
C6orf106
0.03
0.03
lasso
3
0.01
7.6e-03
-5.0
-5.4
5.2e-08
0.97
0.00
0.94
FALSE
2
GTEx
Brain Cortex
C6orf106
0.22
0.07
enet
16
0.10
1.1e-03
-4.2
-5.4
8.1e-08
0.59
0.06
0.84
FALSE
1
CommonMind
Brain Pre-frontal Cortex
C6orf106
0.29
0.21
bslmm
382
0.23
6.9e-28
-4.1
-5.2
1.9e-07
0.75
0.16
0.78
FALSE