[Hub]/) : Traits : LDL Cholesterol :

chr5:73,626,450-75,704,085

Best TWAS P=1.69e-41 · Best GWAS P=5.12e-45 conditioned to 5.68e-06

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ANKRD31 0.10 0.13 lasso 9 0.13 3.9e-15 8.8 -8.2 1.7e-16 -0.41 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex POC5 0.17 0.16 lasso 5 0.15 5.2e-18 10.0 -10.0 1.6e-23 -0.64 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous POC5 0.08 0.07 lasso 7 0.07 3.2e-06 5.3 5.3 1.1e-07 0.37 0.96 0.00 FALSE
4 GTEx Adipose Visceral Omentum POC5 0.13 0.08 lasso 9 0.08 6.1e-05 5.1 5.7 1.3e-08 0.35 0.88 0.01 FALSE
5 GTEx Adrenal Gland GCNT4 0.13 0.02 lasso 8 0.01 1.3e-01 4.0 7.0 2.6e-12 0.46 0.26 0.32 FALSE
6 GTEx Brain Cerebellar Hemisphere POLK 0.27 0.20 lasso 6 0.16 8.3e-05 9.3 9.6 9.6e-22 0.64 0.28 0.30 FALSE
7 GTEx Brain Hypothalamus CTC-366B18.4 0.26 0.12 lasso 8 0.07 9.0e-03 5.3 -5.5 3.9e-08 -0.38 0.10 0.06 FALSE
8 GTEx Cells EBV-transformed lymphocytes POC5 0.47 0.36 lasso 4 0.39 1.3e-13 5.3 5.3 1.2e-07 0.38 1.00 0.00 FALSE
9 GTEx Cells Transformed fibroblasts POLK 0.06 0.04 lasso 3 0.04 1.0e-03 5.8 -6.7 1.7e-11 -0.45 0.44 0.03 FALSE
10 GTEx Cells Transformed fibroblasts POC5 0.15 0.17 lasso 6 0.16 3.4e-12 5.1 5.1 3.1e-07 0.33 1.00 0.00 FALSE
11 GTEx Esophagus Mucosa COL4A3BP 0.09 0.06 lasso 5 0.05 4.2e-04 11.3 -11.7 7.2e-32 -0.69 0.36 0.57 FALSE
12 GTEx Esophagus Mucosa POC5 0.18 0.16 lasso 1 0.15 4.8e-10 5.1 5.1 3.1e-07 0.33 1.00 0.00 FALSE
13 GTEx Nerve Tibial POC5 0.16 0.12 lasso 5 0.10 7.6e-08 5.3 5.2 2.0e-07 0.35 0.99 0.00 FALSE
14 GTEx Pancreas POC5 0.32 0.23 lasso 3 0.21 3.5e-09 5.1 5.1 2.9e-07 0.34 1.00 0.00 FALSE
15 GTEx Spleen POLK 0.18 -0.01 lasso 16 0.03 5.1e-02 10.6 10.2 1.9e-24 0.60 0.16 0.22 FALSE
16 GTEx Spleen POC5 0.42 0.37 lasso 4 0.34 1.3e-09 5.3 5.4 7.9e-08 0.39 0.97 0.00 FALSE
17 GTEx Spleen CTC-366B18.2 0.16 0.11 lasso 3 0.14 2.2e-04 5.3 7.2 5.0e-13 0.50 0.22 0.20 FALSE
18 GTEx Testis POC5 0.27 0.13 lasso 8 0.09 8.1e-05 7.6 -7.7 1.4e-14 -0.43 0.72 0.02 FALSE
19 GTEx Testis GCNT4 0.42 0.35 enet 62 0.37 3.8e-17 8.7 7.5 5.5e-14 0.46 1.00 0.00 FALSE
20 GTEx Thyroid CTC-366B18.2 0.06 0.03 lasso 9 0.02 6.2e-03 9.2 9.2 3.1e-20 0.57 0.30 0.18 FALSE
21 METSIM Adipose POLK 0.05 0.01 enet 16 0.03 4.3e-05 12.3 10.6 3.6e-26 0.68 0.02 0.98 FALSE
22 ROSMAP Brain Pre-frontal Cortex POLK 0.03 0.01 lasso 7 0.02 3.9e-03 7.8 9.4 3.3e-21 0.62 0.63 0.13 FALSE
23 ROSMAP Brain Pre-frontal Cortex ANKDD1B 0.07 0.00 bslmm 382 0.03 7.0e-05 3.7 -7.4 1.7e-13 -0.44 0.17 0.04 FALSE
24 The Cancer Genome Atlas Colon Adenocarcinoma GCNT4 0.10 0.06 enet 6 0.05 8.7e-04 3.7 -6.8 9.4e-12 -0.43 0.08 0.54 FALSE
25 The Cancer Genome Atlas Brain Lower Grade Glioma POC5 0.04 0.00 enet 7 0.03 2.1e-04 10.0 -7.3 3.0e-13 -0.42 0.01 0.82 FALSE
26 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HMGCR 0.04 0.02 enet 4 0.03 6.0e-03 14.1 13.5 1.7e-41 0.89 0.00 0.93 TRUE
27 The Cancer Genome Atlas Prostate Adenocarcinoma POLK 0.03 0.01 blup 53 0.01 1.6e-02 7.5 -10.1 8.8e-24 -0.63 0.33 0.40 FALSE
28 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma POC5 0.24 0.13 blup 70 0.14 1.2e-04 7.8 6.8 1.1e-11 0.35 0.17 0.34 FALSE