[Hub]/) : Traits : LDL Cholesterol : ← →

chr5:73,626,450-75,704,085

Best TWAS P=1.69e-41 · Best GWAS P=5.12e-45 conditioned to 5.68e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMGCR	0.04	0.02	enet	4	0.03	6.0e-03	14.1	13.5	1.7e-41	0.89	0.00	0.93	TRUE
11	GTEx	Esophagus Mucosa	COL4A3BP	0.09	0.06	lasso	5	0.05	4.2e-04	11.3	-11.7	7.2e-32	-0.69	0.36	0.57	FALSE
21	METSIM	Adipose	POLK	0.05	0.01	enet	16	0.03	4.3e-05	12.3	10.6	3.6e-26	0.68	0.02	0.98	FALSE
15	GTEx	Spleen	POLK	0.18	-0.01	lasso	16	0.03	5.1e-02	10.6	10.2	1.9e-24	0.60	0.16	0.22	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLK	0.03	0.01	blup	53	0.01	1.6e-02	7.5	-10.1	8.8e-24	-0.63	0.33	0.40	FALSE
2	CommonMind	Brain Pre-frontal Cortex	POC5	0.17	0.16	lasso	5	0.15	5.2e-18	10.0	-10.0	1.6e-23	-0.64	1.00	0.00	FALSE
6	GTEx	Brain Cerebellar Hemisphere	POLK	0.27	0.20	lasso	6	0.16	8.3e-05	9.3	9.6	9.6e-22	0.64	0.28	0.30	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	POLK	0.03	0.01	lasso	7	0.02	3.9e-03	7.8	9.4	3.3e-21	0.62	0.63	0.13	FALSE
20	GTEx	Thyroid	CTC-366B18.2	0.06	0.03	lasso	9	0.02	6.2e-03	9.2	9.2	3.1e-20	0.57	0.30	0.18	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ANKRD31	0.10	0.13	lasso	9	0.13	3.9e-15	8.8	-8.2	1.7e-16	-0.41	1.00	0.00	FALSE
18	GTEx	Testis	POC5	0.27	0.13	lasso	8	0.09	8.1e-05	7.6	-7.7	1.4e-14	-0.43	0.72	0.02	FALSE
19	GTEx	Testis	GCNT4	0.42	0.35	enet	62	0.37	3.8e-17	8.7	7.5	5.5e-14	0.46	1.00	0.00	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	ANKDD1B	0.07	0.00	bslmm	382	0.03	7.0e-05	3.7	-7.4	1.7e-13	-0.44	0.17	0.04	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	POC5	0.04	0.00	enet	7	0.03	2.1e-04	10.0	-7.3	3.0e-13	-0.42	0.01	0.82	FALSE
17	GTEx	Spleen	CTC-366B18.2	0.16	0.11	lasso	3	0.14	2.2e-04	5.3	7.2	5.0e-13	0.50	0.22	0.20	FALSE
5	GTEx	Adrenal Gland	GCNT4	0.13	0.02	lasso	8	0.01	1.3e-01	4.0	7.0	2.6e-12	0.46	0.26	0.32	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	GCNT4	0.10	0.06	enet	6	0.05	8.7e-04	3.7	-6.8	9.4e-12	-0.43	0.08	0.54	FALSE
28	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	POC5	0.24	0.13	blup	70	0.14	1.2e-04	7.8	6.8	1.1e-11	0.35	0.17	0.34	FALSE
9	GTEx	Cells Transformed fibroblasts	POLK	0.06	0.04	lasso	3	0.04	1.0e-03	5.8	-6.7	1.7e-11	-0.45	0.44	0.03	FALSE
4	GTEx	Adipose Visceral Omentum	POC5	0.13	0.08	lasso	9	0.08	6.1e-05	5.1	5.7	1.3e-08	0.35	0.88	0.01	FALSE
7	GTEx	Brain Hypothalamus	CTC-366B18.4	0.26	0.12	lasso	8	0.07	9.0e-03	5.3	-5.5	3.9e-08	-0.38	0.10	0.06	FALSE
16	GTEx	Spleen	POC5	0.42	0.37	lasso	4	0.34	1.3e-09	5.3	5.4	7.9e-08	0.39	0.97	0.00	FALSE
3	GTEx	Adipose Subcutaneous	POC5	0.08	0.07	lasso	7	0.07	3.2e-06	5.3	5.3	1.1e-07	0.37	0.96	0.00	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	POC5	0.47	0.36	lasso	4	0.39	1.3e-13	5.3	5.3	1.2e-07	0.38	1.00	0.00	FALSE
13	GTEx	Nerve Tibial	POC5	0.16	0.12	lasso	5	0.10	7.6e-08	5.3	5.2	2.0e-07	0.35	0.99	0.00	FALSE
14	GTEx	Pancreas	POC5	0.32	0.23	lasso	3	0.21	3.5e-09	5.1	5.1	2.9e-07	0.34	1.00	0.00	FALSE
10	GTEx	Cells Transformed fibroblasts	POC5	0.15	0.17	lasso	6	0.16	3.4e-12	5.1	5.1	3.1e-07	0.33	1.00	0.00	FALSE
12	GTEx	Esophagus Mucosa	POC5	0.18	0.16	lasso	1	0.15	4.8e-10	5.1	5.1	3.1e-07	0.33	1.00	0.00	FALSE