[Hub]/) : Traits : LDL Cholesterol : ← →

chr17:44,788,310-46,474,610

Best TWAS P=1.3e-11 · Best GWAS P=3.92e-09 conditioned to 0.0421

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Liver	EFCAB13	0.20	0.04	enet	22	0.06	1.1e-02	4.7	6.8	1.3e-11	-0.64	0.04	0.86	TRUE
15	GTEx	Pituitary	EFCAB13	0.39	0.19	enet	23	0.26	3.5e-07	5.8	6.7	2.3e-11	-0.69	0.04	0.95	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C17orf57	0.29	0.17	enet	15	0.20	1.7e-22	5.8	6.4	1.9e-10	-0.67	0.01	0.99	FALSE
2	GTEx	Adrenal Gland	EFCAB13	0.39	0.10	lasso	10	0.23	1.1e-08	-5.9	6.3	3.1e-10	-0.70	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C17orf57	0.16	0.13	blup	73	0.09	3.7e-04	-5.9	6.3	3.1e-10	-0.85	0.01	0.96	FALSE
4	GTEx	Adrenal Gland	MRPL45P2	0.18	0.15	enet	15	0.09	3.4e-04	5.8	6.2	6.8e-10	-0.76	0.04	0.96	FALSE
5	GTEx	Artery Tibial	EFCAB13	0.12	0.06	lasso	7	0.08	1.2e-06	-5.9	6.1	1.1e-09	-0.92	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Rectum Adenocarcinoma	C17orf57	0.15	0.17	blup	70	0.11	1.4e-03	-5.9	6.1	1.1e-09	-0.88	0.01	0.80	FALSE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C17orf57	0.06	0.08	enet	7	0.07	2.1e-06	5.8	6.0	1.7e-09	-0.61	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	C17orf57	0.11	0.05	lasso	3	0.05	8.2e-05	5.5	5.9	2.7e-09	-0.61	0.02	0.94	FALSE
20	GTEx	Testis	EFCAB13	0.25	0.26	enet	18	0.25	2.4e-11	-5.5	5.9	4.9e-09	-0.80	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf57	0.15	0.13	enet	16	0.15	4.2e-29	5.4	5.8	5.4e-09	-0.61	0.05	0.95	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	EFCAB13	0.15	-0.01	enet	23	0.01	8.6e-02	3.9	5.8	6.9e-09	-0.39	0.04	0.50	FALSE
13	GTEx	Nerve Tibial	RP11-580I16.2	0.06	0.08	enet	10	0.06	3.2e-05	5.8	-5.6	2.2e-08	0.45	0.03	0.96	FALSE
6	GTEx	Brain Hippocampus	RP11-580I16.2	0.19	0.07	enet	10	0.10	2.9e-03	2.5	-5.5	3.0e-08	0.52	0.08	0.54	FALSE
3	GTEx	Adrenal Gland	TBKBP1	0.15	0.10	enet	19	0.14	9.2e-06	-5.1	-5.5	3.4e-08	0.51	0.11	0.85	FALSE
24	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C17orf57	0.28	0.16	lasso	6	0.15	1.4e-07	5.8	5.5	4.6e-08	-0.51	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	C17orf57	0.44	0.18	enet	21	0.26	3.7e-27	5.8	5.5	5.0e-08	-0.55	0.01	0.99	FALSE
7	GTEx	Esophagus Mucosa	MRPL45P2	0.11	0.13	enet	12	0.11	1.1e-07	-5.2	5.4	6.1e-08	-0.56	0.07	0.93	FALSE
11	GTEx	Muscle Skeletal	MRPL45P2	0.09	0.10	lasso	4	0.10	9.8e-10	5.5	5.4	6.3e-08	-0.55	0.10	0.90	FALSE
8	GTEx	Esophagus Muscularis	EFCAB13	0.13	0.14	lasso	4	0.10	6.6e-07	5.5	5.4	6.4e-08	-0.46	0.04	0.96	FALSE
14	GTEx	Ovary	EFCAB13	0.25	0.22	lasso	2	0.18	4.4e-05	5.4	5.4	6.8e-08	-0.64	0.04	0.78	FALSE
17	GTEx	Skin Sun Exposed Lower leg	MRPL45P2	0.17	0.17	lasso	5	0.17	3.8e-14	-5.1	5.3	8.9e-08	-0.56	0.14	0.86	FALSE
9	GTEx	Esophagus Muscularis	MRPL45P2	0.10	0.06	lasso	3	0.05	6.4e-04	-5.1	5.3	1.1e-07	-0.57	0.14	0.82	FALSE
27	The Cancer Genome Atlas	Soft Tissue Sarcoma	C17orf57	0.17	0.13	blup	73	0.12	1.7e-07	5.5	5.2	1.8e-07	-0.41	0.02	0.98	FALSE
19	GTEx	Stomach	MRPL45P2	0.15	0.14	lasso	7	0.14	3.8e-07	-5.2	5.2	2.1e-07	-0.58	0.09	0.91	FALSE
18	GTEx	Stomach	EFCAB13	0.22	0.14	enet	36	0.18	3.2e-09	5.4	5.2	2.3e-07	-0.44	0.08	0.92	FALSE
1	GTEx	Adipose Subcutaneous	TBKBP1	0.08	0.09	lasso	4	0.11	3.8e-09	-4.4	-5.2	2.4e-07	0.60	0.46	0.54	FALSE
12	GTEx	Nerve Tibial	EFCAB13	0.33	0.10	enet	42	0.26	1.7e-18	5.4	5.2	2.4e-07	-0.55	0.02	0.98	FALSE