[Hub]/) : Traits : LDL Cholesterol :

chr17:44,788,310-46,474,610

Best TWAS P=1.3e-11 · Best GWAS P=3.92e-09 conditioned to 0.0421

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous TBKBP1 0.08 0.09 lasso 4 0.11 3.8e-09 -4.4 -5.2 2.4e-07 0.60 0.46 0.54 FALSE
2 GTEx Adrenal Gland EFCAB13 0.39 0.10 lasso 10 0.23 1.1e-08 -5.9 6.3 3.1e-10 -0.70 0.01 0.99 FALSE
3 GTEx Adrenal Gland TBKBP1 0.15 0.10 enet 19 0.14 9.2e-06 -5.1 -5.5 3.4e-08 0.51 0.11 0.85 FALSE
4 GTEx Adrenal Gland MRPL45P2 0.18 0.15 enet 15 0.09 3.4e-04 5.8 6.2 6.8e-10 -0.76 0.04 0.96 FALSE
5 GTEx Artery Tibial EFCAB13 0.12 0.06 lasso 7 0.08 1.2e-06 -5.9 6.1 1.1e-09 -0.92 0.01 0.99 FALSE
6 GTEx Brain Hippocampus RP11-580I16.2 0.19 0.07 enet 10 0.10 2.9e-03 2.5 -5.5 3.0e-08 0.52 0.08 0.54 FALSE
7 GTEx Esophagus Mucosa MRPL45P2 0.11 0.13 enet 12 0.11 1.1e-07 -5.2 5.4 6.1e-08 -0.56 0.07 0.93 FALSE
8 GTEx Esophagus Muscularis EFCAB13 0.13 0.14 lasso 4 0.10 6.6e-07 5.5 5.4 6.4e-08 -0.46 0.04 0.96 FALSE
9 GTEx Esophagus Muscularis MRPL45P2 0.10 0.06 lasso 3 0.05 6.4e-04 -5.1 5.3 1.1e-07 -0.57 0.14 0.82 FALSE
10 GTEx Liver EFCAB13 0.20 0.04 enet 22 0.06 1.1e-02 4.7 6.8 1.3e-11 -0.64 0.04 0.86 TRUE
11 GTEx Muscle Skeletal MRPL45P2 0.09 0.10 lasso 4 0.10 9.8e-10 5.5 5.4 6.3e-08 -0.55 0.10 0.90 FALSE
12 GTEx Nerve Tibial EFCAB13 0.33 0.10 enet 42 0.26 1.7e-18 5.4 5.2 2.4e-07 -0.55 0.02 0.98 FALSE
13 GTEx Nerve Tibial RP11-580I16.2 0.06 0.08 enet 10 0.06 3.2e-05 5.8 -5.6 2.2e-08 0.45 0.03 0.96 FALSE
14 GTEx Ovary EFCAB13 0.25 0.22 lasso 2 0.18 4.4e-05 5.4 5.4 6.8e-08 -0.64 0.04 0.78 FALSE
15 GTEx Pituitary EFCAB13 0.39 0.19 enet 23 0.26 3.5e-07 5.8 6.7 2.3e-11 -0.69 0.04 0.95 FALSE
16 GTEx Skin Not Sun Exposed Suprapubic EFCAB13 0.15 -0.01 enet 23 0.01 8.6e-02 3.9 5.8 6.9e-09 -0.39 0.04 0.50 FALSE
17 GTEx Skin Sun Exposed Lower leg MRPL45P2 0.17 0.17 lasso 5 0.17 3.8e-14 -5.1 5.3 8.9e-08 -0.56 0.14 0.86 FALSE
18 GTEx Stomach EFCAB13 0.22 0.14 enet 36 0.18 3.2e-09 5.4 5.2 2.3e-07 -0.44 0.08 0.92 FALSE
19 GTEx Stomach MRPL45P2 0.15 0.14 lasso 7 0.14 3.8e-07 -5.2 5.2 2.1e-07 -0.58 0.09 0.91 FALSE
20 GTEx Testis EFCAB13 0.25 0.26 enet 18 0.25 2.4e-11 -5.5 5.9 4.9e-09 -0.80 0.02 0.98 FALSE
21 The Cancer Genome Atlas Bladder Urothelial Carcinoma C17orf57 0.06 0.08 enet 7 0.07 2.1e-06 5.8 6.0 1.7e-09 -0.61 0.01 0.99 FALSE
22 The Cancer Genome Atlas Breast Invasive Carcinoma C17orf57 0.15 0.13 enet 16 0.15 4.2e-29 5.4 5.8 5.4e-09 -0.61 0.05 0.95 FALSE
23 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C17orf57 0.29 0.17 enet 15 0.20 1.7e-22 5.8 6.4 1.9e-10 -0.67 0.01 0.99 FALSE
24 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C17orf57 0.28 0.16 lasso 6 0.15 1.4e-07 5.8 5.5 4.6e-08 -0.51 0.01 0.99 FALSE
25 The Cancer Genome Atlas Prostate Adenocarcinoma C17orf57 0.44 0.18 enet 21 0.26 3.7e-27 5.8 5.5 5.0e-08 -0.55 0.01 0.99 FALSE
26 The Cancer Genome Atlas Rectum Adenocarcinoma C17orf57 0.15 0.17 blup 70 0.11 1.4e-03 -5.9 6.1 1.1e-09 -0.88 0.01 0.80 FALSE
27 The Cancer Genome Atlas Soft Tissue Sarcoma C17orf57 0.17 0.13 blup 73 0.12 1.7e-07 5.5 5.2 1.8e-07 -0.41 0.02 0.98 FALSE
28 The Cancer Genome Atlas Stomach Adenocarcinoma C17orf57 0.11 0.05 lasso 3 0.05 8.2e-05 5.5 5.9 2.7e-09 -0.61 0.02 0.94 FALSE
29 The Cancer Genome Atlas Testicular Germ Cell Tumors C17orf57 0.16 0.13 blup 73 0.09 3.7e-04 -5.9 6.3 3.1e-10 -0.85 0.01 0.96 FALSE