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chr19:9,982,334-12,191,233

Best TWAS P=3.56e-56 · Best GWAS P=4.28e-117 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPC24	0.06	0.00	enet	15	0.01	1.4e-02	-19.00	15.8	3.6e-56	-0.35	0.00	0.55	TRUE
15	YFS	Blood	SMARCA4	0.02	0.01	enet	3	0.00	9.2e-03	-8.32	11.2	2.9e-29	-0.39	0.15	0.07	TRUE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	KANK2	0.28	0.26	lasso	3	0.26	4.6e-29	8.65	8.5	2.0e-17	-0.02	1.00	0.00	TRUE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	KANK2	0.09	0.04	blup	76	0.06	9.5e-07	8.13	7.9	2.3e-15	-0.13	0.39	0.12	TRUE
10	GTEx	Skin Sun Exposed Lower leg	SMARCA4	0.15	0.10	enet	25	0.15	1.4e-12	-9.98	7.2	7.2e-13	-0.32	1.00	0.00	TRUE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SPC24	0.08	0.01	blup	61	0.05	1.7e-06	0.15	7.0	1.8e-12	-0.22	0.24	0.03	TRUE
3	GTEx	Brain Frontal Cortex BA9	CARM1	0.15	0.02	lasso	3	0.00	2.8e-01	-7.43	6.8	9.2e-12	-0.24	0.08	0.07	TRUE
14	ROSMAP	Brain Pre-frontal Cortex	CARM1	0.11	0.04	blup	380	0.07	7.6e-09	-7.19	6.6	3.2e-11	-0.14	1.00	0.00	TRUE
5	GTEx	Colon Transverse	SMARCA4	0.21	-0.01	enet	21	0.00	1.8e-01	-3.54	6.1	1.1e-09	-0.09	0.06	0.04	TRUE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	DOCK6	0.08	0.01	enet	10	0.04	7.2e-06	-3.71	5.5	4.2e-08	-0.13	0.05	0.03	TRUE
2	GTEx	Adipose Subcutaneous	EPOR	0.11	0.04	lasso	7	0.04	3.8e-04	-12.10	-12.4	4.5e-35	0.48	0.52	0.38	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	C19orf80	0.08	0.04	enet	17	0.05	3.1e-07	3.55	12.1	1.4e-33	-0.41	0.65	0.33	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C19orf52	0.04	0.04	blup	27	0.03	1.7e-04	-9.76	11.0	5.6e-28	-0.37	0.00	1.00	FALSE
6	GTEx	Esophagus Mucosa	SMARCA4	0.18	0.03	enet	15	0.09	8.2e-07	-7.90	10.3	5.0e-25	-0.36	0.95	0.00	FALSE
12	NTR	Blood	SMARCA4	0.07	0.06	lasso	11	0.06	9.0e-18	-9.80	10.2	1.7e-24	-0.38	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	C19orf52	0.05	0.06	lasso	4	0.06	2.5e-06	-8.79	9.8	1.5e-22	-0.36	0.01	0.99	FALSE
4	GTEx	Cells Transformed fibroblasts	CARM1	0.11	0.01	lasso	4	0.00	6.9e-01	-8.66	-9.5	1.7e-21	0.35	0.29	0.04	FALSE
7	GTEx	Esophagus Muscularis	SMARCA4	0.16	0.00	lasso	6	0.03	7.2e-03	-12.30	8.7	3.3e-18	-0.39	0.17	0.08	FALSE
11	GTEx	Skin Sun Exposed Lower leg	YIPF2	0.05	0.05	lasso	2	0.04	1.6e-04	-8.37	8.5	1.6e-17	-0.33	0.53	0.29	FALSE
9	GTEx	Pancreas	LDLR	0.19	-0.01	enet	5	0.01	9.7e-02	-0.71	-7.7	1.3e-14	0.50	0.02	0.71	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CDKN2D	0.04	0.01	blup	360	0.01	3.1e-02	-1.99	7.4	1.4e-13	-0.26	0.46	0.03	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	C19orf52	0.05	0.04	lasso	2	0.02	1.6e-03	7.28	7.0	3.1e-12	-0.27	0.13	0.20	FALSE
8	GTEx	Muscle Skeletal	SLC44A2	0.19	0.18	lasso	5	0.19	5.1e-18	-6.93	-6.7	1.6e-11	0.21	1.00	0.00	FALSE