Best TWAS P=3.56e-56 · Best GWAS P=4.28e-117 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CDKN2D | 0.04 | 0.01 | blup | 360 | 0.01 | 3.1e-02 | -1.99 | 7.4 | 1.4e-13 | -0.26 | 0.46 | 0.03 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | EPOR | 0.11 | 0.04 | lasso | 7 | 0.04 | 3.8e-04 | -12.10 | -12.4 | 4.5e-35 | 0.48 | 0.52 | 0.38 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | CARM1 | 0.15 | 0.02 | lasso | 3 | 0.00 | 2.8e-01 | -7.43 | 6.8 | 9.2e-12 | -0.24 | 0.08 | 0.07 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | CARM1 | 0.11 | 0.01 | lasso | 4 | 0.00 | 6.9e-01 | -8.66 | -9.5 | 1.7e-21 | 0.35 | 0.29 | 0.04 | FALSE |
| 5 | GTEx | Colon Transverse | SMARCA4 | 0.21 | -0.01 | enet | 21 | 0.00 | 1.8e-01 | -3.54 | 6.1 | 1.1e-09 | -0.09 | 0.06 | 0.04 | TRUE |
| 6 | GTEx | Esophagus Mucosa | SMARCA4 | 0.18 | 0.03 | enet | 15 | 0.09 | 8.2e-07 | -7.90 | 10.3 | 5.0e-25 | -0.36 | 0.95 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Muscularis | SMARCA4 | 0.16 | 0.00 | lasso | 6 | 0.03 | 7.2e-03 | -12.30 | 8.7 | 3.3e-18 | -0.39 | 0.17 | 0.08 | FALSE |
| 8 | GTEx | Muscle Skeletal | SLC44A2 | 0.19 | 0.18 | lasso | 5 | 0.19 | 5.1e-18 | -6.93 | -6.7 | 1.6e-11 | 0.21 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Pancreas | LDLR | 0.19 | -0.01 | enet | 5 | 0.01 | 9.7e-02 | -0.71 | -7.7 | 1.3e-14 | 0.50 | 0.02 | 0.71 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | SMARCA4 | 0.15 | 0.10 | enet | 25 | 0.15 | 1.4e-12 | -9.98 | 7.2 | 7.2e-13 | -0.32 | 1.00 | 0.00 | TRUE |
| 11 | GTEx | Skin Sun Exposed Lower leg | YIPF2 | 0.05 | 0.05 | lasso | 2 | 0.04 | 1.6e-04 | -8.37 | 8.5 | 1.6e-17 | -0.33 | 0.53 | 0.29 | FALSE |
| 12 | NTR | Blood | SMARCA4 | 0.07 | 0.06 | lasso | 11 | 0.06 | 9.0e-18 | -9.80 | 10.2 | 1.7e-24 | -0.38 | 1.00 | 0.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | C19orf80 | 0.08 | 0.04 | enet | 17 | 0.05 | 3.1e-07 | 3.55 | 12.1 | 1.4e-33 | -0.41 | 0.65 | 0.33 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | CARM1 | 0.11 | 0.04 | blup | 380 | 0.07 | 7.6e-09 | -7.19 | 6.6 | 3.2e-11 | -0.14 | 1.00 | 0.00 | TRUE |
| 15 | YFS | Blood | SMARCA4 | 0.02 | 0.01 | enet | 3 | 0.00 | 9.2e-03 | -8.32 | 11.2 | 2.9e-29 | -0.39 | 0.15 | 0.07 | TRUE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SPC24 | 0.08 | 0.01 | blup | 61 | 0.05 | 1.7e-06 | 0.15 | 7.0 | 1.8e-12 | -0.22 | 0.24 | 0.03 | TRUE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C19orf52 | 0.04 | 0.04 | blup | 27 | 0.03 | 1.7e-04 | -9.76 | 11.0 | 5.6e-28 | -0.37 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C19orf52 | 0.05 | 0.04 | lasso | 2 | 0.02 | 1.6e-03 | 7.28 | 7.0 | 3.1e-12 | -0.27 | 0.13 | 0.20 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DOCK6 | 0.08 | 0.01 | enet | 10 | 0.04 | 7.2e-06 | -3.71 | 5.5 | 4.2e-08 | -0.13 | 0.05 | 0.03 | TRUE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KANK2 | 0.28 | 0.26 | lasso | 3 | 0.26 | 4.6e-29 | 8.65 | 8.5 | 2.0e-17 | -0.02 | 1.00 | 0.00 | TRUE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KANK2 | 0.09 | 0.04 | blup | 76 | 0.06 | 9.5e-07 | 8.13 | 7.9 | 2.3e-15 | -0.13 | 0.39 | 0.12 | TRUE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SPC24 | 0.06 | 0.00 | enet | 15 | 0.01 | 1.4e-02 | -19.00 | 15.8 | 3.6e-56 | -0.35 | 0.00 | 0.55 | TRUE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | C19orf52 | 0.05 | 0.06 | lasso | 4 | 0.06 | 2.5e-06 | -8.79 | 9.8 | 1.5e-22 | -0.36 | 0.01 | 0.99 | FALSE |