[Hub]/) : Traits : LDL Cholesterol : ← →

chr1:61,510,619-63,844,736

Best TWAS P=6.14e-18 · Best GWAS P=2.63e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Tibial	DOCK7	0.07	0.07	enet	20	0.07	3.5e-06	-8.5	8.6	6.1e-18	-0.98	0.05	0.95	TRUE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DOCK7	0.06	0.07	blup	86	0.07	1.0e-04	-8.6	8.6	8.2e-18	-0.98	0.05	0.95	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	DOCK7	0.01	0.01	blup	85	0.01	1.1e-03	-8.4	8.6	8.6e-18	-0.99	0.05	0.92	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	DOCK7	0.04	0.01	enet	3	0.02	3.0e-03	-8.4	8.6	1.2e-17	-0.98	0.05	0.66	FALSE
10	GTEx	Whole Blood	USP1	0.05	0.02	lasso	1	0.02	1.0e-02	-8.5	8.5	1.5e-17	-0.99	0.05	0.91	FALSE
6	GTEx	Skin Not Sun Exposed Suprapubic	DOCK7	0.17	0.01	lasso	2	0.00	2.5e-01	-8.5	8.5	1.7e-17	-1.00	0.04	0.70	FALSE
7	GTEx	Skin Sun Exposed Lower leg	DOCK7	0.09	0.10	lasso	3	0.10	2.7e-08	-8.5	8.5	1.9e-17	-1.00	0.04	0.96	FALSE
9	GTEx	Whole Blood	DOCK7	0.06	0.00	lasso	6	0.00	1.6e-01	-8.2	8.5	2.5e-17	-0.98	0.06	0.88	FALSE
13	YFS	Blood	DOCK7	0.05	0.04	lasso	8	0.05	1.3e-14	-8.5	8.3	6.7e-17	-0.97	0.04	0.96	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	DOCK7	0.07	0.06	blup	83	0.06	2.1e-04	-8.6	8.3	9.9e-17	-0.95	0.05	0.93	FALSE
4	GTEx	Cells Transformed fibroblasts	DOCK7	0.23	0.21	lasso	5	0.28	4.9e-21	-8.2	8.2	2.5e-16	-0.95	0.06	0.94	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	DOCK7	0.05	0.03	blup	86	0.02	1.6e-03	-7.4	8.2	3.4e-16	-0.93	0.06	0.90	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	DOCK7	0.06	0.06	lasso	6	0.06	3.7e-08	-8.4	-8.1	6.4e-16	0.94	0.05	0.95	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DOCK7	0.12	0.05	lasso	8	0.07	9.2e-09	-8.7	8.0	1.2e-15	-0.90	0.04	0.96	FALSE
2	GTEx	Artery Aorta	DOCK7	0.14	0.08	lasso	4	0.09	1.2e-05	-8.4	7.9	3.4e-15	-0.92	0.05	0.95	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DOCK7	0.08	0.05	enet	29	0.10	7.8e-05	-8.5	7.7	9.7e-15	-0.91	0.04	0.95	FALSE
8	GTEx	Spleen	DOCK7	0.28	0.14	enet	33	0.22	2.1e-06	-8.5	7.5	5.3e-14	-0.72	0.04	0.91	FALSE
5	GTEx	Esophagus Mucosa	DOCK7	0.15	0.04	lasso	5	0.02	1.0e-02	-8.4	7.2	7.0e-13	-0.82	0.05	0.88	FALSE
11	NTR	Blood	DOCK7	0.02	0.00	blup	647	0.01	1.5e-03	-8.4	6.9	6.8e-12	-0.84	0.05	0.94	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOCK7	0.04	0.01	enet	11	0.04	5.6e-05	-8.5	6.3	2.9e-10	-0.70	0.04	0.90	FALSE
1	GTEx	Adipose Visceral Omentum	INADL	0.22	0.03	lasso	6	0.05	1.3e-03	-8.4	5.7	1.2e-08	-0.76	0.05	0.70	FALSE