TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
LDL Cholesterol
:
←
→
chr2:43,302,571-44,735,953
Best TWAS P=1.08e-14 · Best GWAS P=1.73e-47 conditioned to 1.63e-31
43.4M
43.6M
43.8M
44M
44.2M
44.4M
44.6M
44.8M
0
10
20
30
40
50
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Prostate Adenocarcinoma
ABCG5
0.05
0.04
blup
75
0.02
1.6e-03
-4.546
7.7
1.1e-14
0.35
0.42
0.13
TRUE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
DYNC2LI1
0.08
0.02
enet
5
0.03
7.7e-05
3.075
-5.7
1.4e-08
-0.19
0.57
0.08
TRUE
2
The Cancer Genome Atlas
Brain Lower Grade Glioma
PLEKHH2
0.08
0.00
blup
127
0.02
1.1e-03
-0.034
5.9
3.6e-09
0.07
0.01
0.61
FALSE
1
CommonMind
Brain Pre-frontal Cortex
DYNC2LI1
0.31
0.15
lasso
12
0.23
1.2e-27
5.106
-5.5
3.4e-08
-0.01
1.00
0.00
FALSE