TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
LDL Cholesterol
:
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→
chr3:11,900,101-13,321,852
Best TWAS P=2.41e-08 · Best GWAS P=2.15e-07 conditioned to 0.0667
12M
12.2M
12.4M
12.6M
12.8M
13M
13.2M
13.4M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Heart Left Ventricle
MKRN2
0.21
0.05
enet
15
0.14
1.1e-07
-3.5
-5.6
2.4e-08
0.69
0.11
0.87
TRUE
2
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
RAF1
0.03
0.02
blup
59
0.02
1.6e-03
-4.2
5.2
2.4e-07
-0.60
0.02
0.90
FALSE