Hub : Genes

RAF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0840	0.0360	5.5e-03	0.022	NA	0.035	NA	0.037	5.5e-03	NA	7.3e-04	NA	5.1e-04
2	YFS	Blood	0.0219	0.0071	2.7e-06	0.033	0.017	0.030	0.022	0.031	4.1e-11	1.9e-06	3.7e-10	9.2e-08	2.1e-10
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0255	0.0137	1.2e-03	0.016	0.021	0.017	NA	0.017	5.4e-03	1.6e-03	4.3e-03	NA	4.7e-03
4	TCGA	Testicular Germ Cell Tumors	0.3140	0.1560	1.9e-05	0.165	0.151	0.153	NA	0.156	1.9e-06	5.3e-06	4.5e-06	NA	3.8e-06
5	TCGA	Thyroid Carcinoma	0.0770	0.0300	7.0e-08	0.052	0.075	0.050	NA	0.058	8.1e-06	9.6e-08	1.3e-05	NA	2.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	2.4	3.8	5.8	-0.6	2.4	-2.3	-1.9	-1.9
Bipolar Disorder or Schizophrenia	2.6	6.3	11.0	-2.5	3.3	-2.4	-2.8	-0.8
Depressed Affect (Nagel 2018)	0.1	0.1	0.4	-0.0	-0.6	0.3	0.2	0.3
Depression (Nagel 2018)	1.4	2.2	3.3	0.9	-1.8	1.8	1.8	0.8
Intelligence (Savage-Jansen 2018)	1.9	5.8	11.8	3.4	-3.1	-1.8	-0.0	-2.1
Neuroticism (Nagel 2018)	0.7	1.6	5.0	-2.2	0.8	-0.3	-1.2	1.0
Schizophrenia (2018)	1.8	3.7	7.2	-2.7	2.3	-1.3	-2.0	0.6
Schizophrenia vs Biploar Disorder	1.5	2.0	3.9	-0.1	-1.3	2.0	1.6	1.4
Worry (Nagel 2018)	2.3	4.8	15.1	-3.9	1.6	0.1	-1.5	2.0
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	-0.2	-0.0	0.8	0.5	0.6
Alzheimer’s Disease (in father)	0.5	0.5	1.0	0.8	-0.3	-1.0	-0.5	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	0.7	0.3	-0.1	-0.1	-0.7
Crohns Disease (2017)	0.6	1.3	3.3	-1.8	1.2	-0.1	-1.0	0.7
Irritable Bowel Disease (IBD)	0.3	0.6	1.2	-1.1	0.3	0.7	0.2	1.1
Ulcerative Colitis (UC)	0.7	1.3	2.3	-0.2	-0.5	1.5	1.5	1.3
Major Depression (MDD)	0.6	0.7	1.8	0.2	-0.3	1.1	1.4	0.6
Reaction Time	0.1	0.2	0.7	-0.4	-0.2	-0.8	-0.5	0.0
Verbal and Numeric Reasoning (VNR)	1.0	2.5	5.3	2.3	-2.2	-0.9	0.3	-1.1
Breast Cancer	0.4	1.1	3.6	1.9	-1.0	-0.2	0.4	-0.8
Ovarian Cancer	0.0	0.0	0.2	-0.0	0.2	-0.0	0.4	-0.1
Prostate Cancer	0.6	0.8	1.8	-0.9	0.5	-1.1	-1.4	-0.3
Age at First Birth	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.2	0.3
Bipolar Disorder (2011)	6.0	5.8	9.5	0.3	2.0	-3.1	-2.7	-2.8
Body Mass Index (BMI) (2010)	0.9	1.3	3.0	1.3	0.3	1.1	1.7	-0.7
Coronary Artery Disease (CAD)	1.6	1.9	5.2	2.3	-1.4	0.4	1.4	-0.6
Crohns Disease (2012)	1.1	1.8	4.2	-2.0	1.5	-0.4	-1.4	0.6
Mean Putamen Volume	0.5	0.5	0.8	0.7	-0.7	-0.9	-0.4	-0.8
Fasting Glucose	0.6	0.7	1.7	0.3	-0.4	1.3	1.3	0.2
HbA1C	2.1	2.3	4.8	-0.2	-0.4	2.2	2.2	1.4
HDL Cholesterol	0.2	0.3	1.3	0.3	-1.2	-0.3	-0.1	0.4
LDL Cholesterol	10.1	16.0	26.6	-0.6	-3.9	5.2	3.9	4.8
Lupus	1.1	1.6	3.2	-0.9	1.5	-1.3	-1.8	-0.6
Neuroticism (2016)	0.3	0.5	0.9	0.7	-0.3	-0.9	-0.3	-0.9
Primary Biliary Cirrhosis	0.1	0.2	0.5	-0.5	0.7	0.2	-0.1	0.1
Rheumatoid Arthritis	7.0	9.7	17.1	-4.1	2.8	-2.5	-4.1	0.6
Schizophrenia (2014)	1.4	3.1	5.4	-2.2	2.3	-1.4	-1.8	0.0
Triglycerides	3.6	5.9	12.5	-0.7	-1.3	3.5	2.6	2.8
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.2	0.4	-1.1	-0.3	0.5	-0.3
Ulcerative Colitis	0.3	0.4	0.8	-0.9	0.7	0.2	0.0	0.7
Blood Eosinophil Count	1.5	11.9	31.3	-5.6	1.4	-2.6	-3.5	2.7
Blood Platelet Count	0.2	2.9	6.7	-1.9	-2.0	0.2	0.2	2.6
Blood Red Count	1.9	18.0	35.2	-0.5	5.9	-4.3	-4.1	-4.3
Blood White Count	0.8	6.2	15.9	-4.0	1.6	-1.9	-2.7	1.4
Heel T-Score	2.6	20.7	42.1	-0.6	3.6	-6.5	-5.5	-4.2
BMI	0.2	1.4	4.2	1.5	0.3	-0.6	0.4	-2.0
Height	2.6	49.8	92.5	6.3	-9.6	6.5	8.3	2.5
Waist Hip Ratio (WHR)	8.5	38.1	59.4	0.7	-7.7	6.8	7.0	5.9
Systolic Blood Pressure	2.3	11.5	21.0	-2.6	-0.8	4.6	2.9	4.6
Smoking Status	0.6	1.4	2.8	-0.3	0.9	-1.7	-1.6	-0.8
Allergy or Eczema	0.6	1.5	4.0	-1.3	-1.3	0.1	-0.1	2.0
Cardiovascular Disease	3.6	11.7	19.7	-0.9	-2.9	4.4	3.5	4.2
Hypothyroidism (self reported)	1.8	4.0	7.3	-2.7	1.8	-1.9	-2.5	0.3
Respiratory disease	0.4	0.9	2.2	0.1	-1.0	-1.5	-1.0	-0.4
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.5	-2.1	0.2	0.4	-0.5	1.2
Lung FEV1/FVC ratio	1.4	6.9	17.6	-0.2	-0.3	4.2	3.2	2.6
Lung FVC	0.3	1.6	2.9	-1.2	1.7	1.0	-0.3	1.5
Neuroticism	0.2	0.4	1.3	-1.1	-0.3	0.1	-0.2	0.7
Chronotype (morning person)	0.3	0.8	2.5	-0.2	-0.5	-0.9	-1.6	0.4
Hair Pigment	0.7	20.0	45.4	-5.7	6.7	-2.0	-4.3	0.4
Tanning	0.1	1.0	2.0	-1.0	-0.4	-1.3	-1.4	0.4
Hand grip strength (left)	0.3	0.8	1.7	0.8	-0.2	-1.2	-0.4	-1.3
Number of treatments/medications taken	1.2	2.2	5.6	-1.8	0.0	1.4	0.6	2.4
Average weekly spirits intake	2.9	3.6	5.6	1.9	-2.4	1.8	2.3	0.4
Sensitivity / hurt feelings	0.3	0.5	1.4	-0.6	-0.4	0.8	0.3	1.2
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.3	0.5	-1.5	0.7	0.7	0.5
Hearing difficulty/problems: Yes	2.3	3.5	6.8	1.8	-0.3	-2.6	-1.6	-2.2
Relative age of first facial hair	2.0	4.2	11.0	3.3	-1.3	-0.4	1.3	-2.5
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	-0.3	0.1	0.0	0.0	0.4
Ever used hormone-replacement therapy (HRT)	1.6	2.0	4.4	-1.1	-0.9	1.7	0.9	2.1
Ever had hysterectomy (womb removed)	2.1	2.3	5.2	-1.4	-0.4	1.8	1.0	2.3
Systolic blood pressure, automated reading	1.3	3.7	7.8	-1.8	-0.5	2.3	1.2	2.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.1	0.6	-0.4	-0.2	-0.6
Angina	0.9	1.2	2.3	0.8	-1.2	1.2	1.5	0.2
Medication for hormone replacement therapy	2.6	2.9	6.2	-1.4	-0.2	2.2	1.1	2.5
Vitamin and mineral supplements	0.3	0.4	0.9	1.0	-0.6	0.4	0.3	-0.7
Supplements: Zinc	0.4	0.4	0.9	-0.9	0.9	0.0	-0.2	0.5
Medication: Co-codamol	0.2	0.2	0.6	-0.5	0.5	0.8	0.4	0.1
Medication: Metformin	0.6	0.9	2.8	-1.7	1.0	0.2	-0.6	0.5
Diabetes (father)	0.4	0.5	1.5	-1.2	-0.1	-0.2	-0.6	0.7
Diabetes (mother)	2.9	3.7	7.0	-2.6	1.6	-1.5	-2.6	0.5
Severe depression (siblings)	0.4	0.5	0.9	0.7	-0.2	1.0	0.9	0.0
Pack years adult smoking proportion	0.1	0.2	0.2	-0.2	-0.4	0.4	0.4	0.5
Impedance of leg (right)	0.4	2.2	4.2	1.8	-0.2	-2.0	-0.8	-1.7
Leg fat-free mass (left)	1.1	6.1	9.6	2.5	-2.9	2.5	3.1	-0.0
Trunk fat percentage	1.4	5.7	12.9	3.6	-0.7	-1.2	0.9	-3.6
Hand grip strength (right)	0.4	1.2	3.0	1.7	-0.9	-0.4	0.6	-1.1
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.4	0.2	-0.0	0.0	-0.6
Current tobacco smoking	0.1	0.2	0.3	-0.4	0.5	-0.4	-0.5	-0.2
Average weekly fortified wine intake	1.2	1.4	3.0	0.7	-1.3	1.2	1.7	0.8
Maternal smoking around birth	0.6	0.9	1.8	-1.2	1.4	-0.2	-1.1	0.1
Fed-up feelings	0.2	0.4	1.0	-0.7	0.2	-0.7	-1.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.9	1.2	-1.3	1.1	1.4	-0.2
Relative age voice broke	2.4	3.7	6.9	2.6	-2.6	0.6	1.9	-0.8
Taking other prescription medications	1.0	1.6	4.7	-2.2	0.6	0.4	-0.5	1.6
Age when periods started (menarche)	0.2	0.6	1.4	1.1	-0.3	-0.4	0.3	-1.2
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	5.9	-1.3	1.0	2.4	1.6	1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	9.4	0.7	1.0	-3.1	-2.0	-2.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	1.2	-0.9	-0.2	0.2	-0.8
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.4	0.3	0.6	0.2	0.3
Serious illness, injury or assault to yourself	0.5	0.6	0.9	-1.0	0.9	-0.2	-0.8	0.6
High blood pressure	0.9	2.5	3.8	-0.1	-1.9	1.9	1.4	1.8
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.7	-1.2	-0.9	-0.6	-0.7	1.3
Multivitamins +/- minerals	0.7	0.9	2.8	-1.1	-0.4	0.6	0.4	1.7
Stomach or abdominal pain in last month	1.7	2.1	5.0	-1.1	-0.7	1.8	0.9	2.2
Supplements: Glucosamine	0.3	0.4	1.1	-1.1	0.2	0.1	-0.3	0.9
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	4.8	0.0	-1.0	2.2	1.7	1.5
Medication: Atenolol	0.3	0.4	1.3	0.6	-1.1	-0.3	0.3	-0.5
Medication: Levothyroxine sodium	0.4	0.6	1.5	-1.2	0.8	-0.7	-0.7	0.0
Sitting height	0.8	5.3	11.4	3.2	-3.4	0.9	1.9	-0.7
Chronic bronchitis/emphysema (father)	1.0	1.2	1.8	-0.0	1.3	-1.2	-1.1	-1.3
High blood pressure (mother)	0.5	0.6	1.6	1.2	-0.4	0.3	0.8	-0.9
Body mass index (BMI)	0.2	0.8	2.8	0.7	0.8	-0.4	0.2	-1.7
Impedance of leg (left)	0.3	1.2	3.2	1.1	-0.0	-1.8	-0.8	-1.1
Leg predicted mass (left)	1.2	6.1	9.7	2.4	-2.9	2.6	3.1	0.1
Trunk fat mass	1.3	5.4	13.8	3.7	-1.4	-0.2	1.7	-2.9
Waist circumference	1.0	3.8	8.1	1.5	-2.0	2.1	2.9	0.2
Number of incorrect matches in round	0.5	0.8	2.0	-1.4	0.1	-0.1	-0.3	1.3
Past tobacco smoking	0.2	0.4	0.9	0.7	-0.6	0.6	1.0	-0.1
Alcohol usually taken with meals	0.1	0.2	0.8	0.5	-0.9	0.2	0.2	0.3
Nervous feelings	1.0	1.8	5.1	-2.3	1.5	-0.7	-1.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.9	-0.5	-1.7	1.3	0.9	1.7
Hearing difficulty/problems with background noise	1.9	3.1	6.6	2.6	-2.2	-1.3	-0.3	-1.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.2	0.2	-0.8	-0.8	0.1
Had menopause	0.4	0.5	1.1	-1.1	0.6	0.5	0.0	0.8
Had other major operations	0.6	0.7	1.3	-0.6	0.5	1.1	0.8	0.9
Forced vital capacity (FVC)	1.4	5.5	10.3	2.6	-3.2	1.9	2.6	0.8
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.5	12.8	0.3	1.8	-3.6	-2.7	-3.0
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.8	-0.9	1.7	-1.2	-1.4	-0.9
Qualifications: None of the above	2.4	5.2	10.6	-2.0	0.2	3.3	1.7	3.0
Financial difficulties in last 2 years	0.7	1.0	2.1	1.5	-0.9	0.6	1.2	-0.2
Mouth/teeth dental problems	0.1	0.1	0.2	0.1	0.4	-0.5	-0.2	-0.3
Heart attack	0.3	0.3	0.9	0.2	0.2	0.8	0.9	0.3
Allergy	0.7	1.6	3.5	1.8	0.9	0.1	0.7	-1.9
Pain all over the body in last month	0.7	0.7	1.5	-1.1	0.2	-1.2	-0.9	-0.2
Diabetes (self-reported)	1.2	1.9	3.3	-1.8	0.1	1.6	0.7	1.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.6	-0.3	0.0	-0.4	0.8
Medication: Ramipril	0.1	0.1	0.2	-0.4	0.5	0.3	-0.3	0.1
Medication: Simvastatin	5.7	8.3	15.0	-0.4	-2.2	3.9	3.4	3.2
Fluid intelligence score	2.2	4.7	11.8	3.0	-3.4	-0.6	1.1	-0.9
Illnesses of siblings	1.0	1.4	2.9	-0.1	1.0	-1.7	-1.4	-1.1
Neuroticism score	0.4	0.8	1.6	-1.3	0.3	-0.8	-1.2	0.2
Weight	1.3	6.4	10.6	3.2	-2.7	1.9	3.1	-1.0
Impedance of arm (right)	1.7	7.8	12.8	3.6	-1.3	-3.3	-0.9	-3.6
Arm fat percentage (right)	1.5	6.0	15.7	3.3	-0.1	-1.8	0.3	-4.0
Trunk fat-free mass	1.7	9.5	16.5	1.5	-3.2	4.1	3.9	1.9
Hip circumference	1.2	5.4	14.9	2.7	0.6	-2.0	-0.4	-3.9
Time employed in main current job	0.2	0.2	0.4	0.2	-0.6	0.6	0.3	0.5
Alcohol intake versus 10 years previously	1.1	1.7	2.3	-1.5	1.5	1.3	0.1	1.5
Father’s age at death	1.3	1.8	3.4	1.8	-1.2	-1.4	-0.7	-1.4
Worrier / anxious feelings	1.4	2.6	8.3	-2.9	1.0	0.2	-1.0	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.1	-0.1	-1.8	1.7	1.2	1.6
Falls in the last year	0.0	0.1	0.1	0.3	-0.4	-0.1	0.0	-0.2
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	-0.7	0.8	0.8	0.4	0.3
Number of live births	0.0	0.0	0.1	0.0	-0.4	0.1	0.2	0.2
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	8.8	2.2	-2.5	2.5	3.0	1.1
Pulse rate	1.1	1.9	5.1	-1.8	-0.4	0.6	-0.6	2.3
Happiness	0.8	1.0	2.1	1.0	-0.3	-1.1	-0.6	-1.4
Noisy workplace	1.0	1.3	3.2	0.7	1.5	-0.4	-0.4	-1.8
Qualifications: A levels/AS levels or equivalent	1.4	3.1	7.2	2.7	-2.2	-0.6	0.8	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.8	1.7	-1.3	0.1	1.4	-0.8
Mouth/teeth dental problems: Dentures	0.5	0.8	1.3	0.1	-0.6	1.2	1.1	1.0
Asthma	0.5	1.1	2.2	-0.6	-1.5	-1.1	-1.2	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.1	0.5	-0.9	-0.3	-0.3
Medication: Cholesterol lowering	4.9	7.7	12.7	0.5	-2.8	3.5	3.6	2.3
Depression (self-reported)	0.2	0.2	0.5	-0.6	-0.2	-0.5	-0.7	0.2
Medication: Lansoprazole	2.1	2.4	3.8	1.3	-1.9	1.5	1.9	0.7
Prospective memory result	0.1	0.1	0.4	-0.1	0.6	-0.1	-0.0	-0.5
Lung cancer (father)	1.5	1.8	4.6	-0.6	0.1	2.1	1.3	1.4
Illnesses of mother	0.9	1.2	3.0	0.6	-1.7	0.8	0.9	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	6.9	10.2	2.0	-3.1	2.7	3.2	1.8
Pulse wave Arterial Stiffness index	3.2	3.8	9.7	-2.1	-0.3	2.0	0.7	3.1
Impedance of arm (left)	1.4	6.7	14.4	3.8	-1.8	-2.4	-0.0	-3.2
Arm fat mass (right)	0.8	3.4	7.8	2.8	-1.0	-0.2	1.3	-2.5
Trunk predicted mass	1.6	9.4	15.9	1.5	-3.2	4.0	3.8	1.8
Standing height	3.2	31.3	59.8	5.4	-7.7	4.9	6.4	1.6
Length of working week for main job	0.6	0.7	1.5	0.9	1.2	-0.0	-0.0	-1.0
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.2	0.6	0.6	-0.3	0.3
Breastfed as a baby	0.7	0.9	1.8	0.9	0.3	-1.1	-0.6	-1.4
Tense / ‘highly strung’	1.9	3.2	8.0	-2.8	1.6	-0.8	-2.0	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.6	-1.3	-0.0	-0.4	-0.6	0.7
Hair/balding pattern: Pattern 4	0.4	1.0	2.4	-0.3	-0.6	-1.6	-1.4	-0.2
Birth weight of first child	0.3	0.6	1.5	1.2	-0.4	-0.6	-0.3	-0.9
Peak expiratory flow (PEF)	2.0	4.5	7.8	1.8	-2.4	2.2	2.8	0.9
Pulse wave reflection index	0.4	0.5	0.9	-0.6	0.7	1.0	0.5	0.5
Ever highly irritable/argumentative for 2 days	1.4	1.7	5.0	-2.2	0.9	-0.1	-1.1	1.2
Loud music exposure frequency	0.7	0.8	1.6	0.1	1.3	1.1	0.9	-0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	1.2	-0.5	-0.7	-0.1	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.3	-1.0	0.7	-0.7	-1.1	-0.2
Blood clot in the leg (DVT)	0.1	0.2	0.3	-0.2	0.3	-0.5	-0.5	-0.4
Medication: Paracetamol	0.5	0.9	2.5	-1.6	0.9	0.1	-0.4	0.9
Headache pain in last month	0.3	0.5	0.7	0.2	-0.8	0.8	0.8	0.7
Medication for cholesterol, blood pressure or diabetes	4.1	6.8	11.7	-0.2	2.6	-3.4	-3.1	-2.5
Glaucoma (self-reported)	0.7	0.9	2.4	-0.7	0.2	-1.5	-1.2	-0.1
Gout (self-reported)	0.7	1.0	2.4	-1.4	-0.0	0.8	-0.3	1.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.1	-1.8	1.1	-0.9	-1.3	0.3
Medication: Amlodipine	1.7	2.4	6.4	-1.4	-1.4	1.3	0.2	2.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.9	0.3	-0.7	-0.8	0.1
Birth weight	2.6	5.6	15.7	2.6	1.1	-2.1	-0.7	-4.0
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.1	0.6	-1.0	-0.6	0.3	-0.2
High blood pressure (siblings)	0.5	0.7	1.4	-0.2	-0.6	1.2	0.8	0.9
Forced vital capacity (FVC), Best measure	1.6	5.8	13.0	2.2	-3.6	1.7	2.5	1.3
Body fat percentage	1.4	5.3	13.6	3.2	-0.0	-1.5	0.5	-3.7
Leg fat percentage (right)	1.1	3.8	10.6	2.1	1.2	-1.6	0.0	-3.2
Arm fat-free mass (right)	1.5	7.8	15.4	0.9	-2.5	3.9	3.6	1.9
Exposure to tobacco smoke outside home	1.7	2.2	5.4	-1.0	0.1	2.3	1.2	1.8
Comparative body size at age 10	1.2	3.3	8.6	1.8	0.8	-1.9	-0.7	-2.9
Number of full brothers	2.0	2.5	6.2	2.0	0.2	-1.5	-0.3	-2.5
Worry too long after embarrassment	2.7	4.5	10.2	-1.2	0.7	-3.1	-3.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.1	-0.9	0.6	0.5	0.7
Wheeze or whistling in the chest in last year	0.7	1.2	3.3	-0.1	-1.8	0.9	0.8	1.1
Number of children fathered	0.3	0.4	0.9	-0.6	0.6	-0.4	-0.9	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.6	-1.5	1.9	-1.0	-1.6	0.2
Age at first live birth	0.7	1.3	3.2	-0.2	-0.4	-1.7	-1.8	-0.2
Pulse wave peak to peak time	3.3	3.9	9.6	2.6	-0.3	-1.7	-0.2	-3.1
Health satisfaction	1.7	2.2	5.0	-1.2	1.3	-1.7	-2.2	-0.5
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.7	0.4	-0.3	-0.4	0.2
Qualifications: College or University degree	1.1	3.3	5.8	2.0	-2.4	-2.1	-0.7	-1.4
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.0	0.2	-0.3	-0.6	0.2
Mouth/teeth dental problems: Loose teeth	1.9	2.2	4.5	1.4	-1.2	1.8	2.1	-0.2
Emphysema/chronic bronchitis	1.6	1.8	2.7	1.4	-1.6	1.3	1.6	0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	1.5	0.9	-0.5	-0.8	-0.6	-1.2
Neck or shoulder pain in last month	0.6	0.9	1.6	0.4	-1.3	1.0	1.0	0.7
Medication: Blood pressure	1.7	2.9	4.5	-0.3	-2.0	2.1	1.4	2.0
Angina (self-reported)	1.3	1.8	3.5	0.8	-1.4	1.5	1.9	0.4
Migraine (self-reported)	1.7	2.1	3.8	0.2	1.2	-1.9	-1.3	-1.9
Medication: Ibuprofen	0.3	0.3	0.6	-0.4	0.8	-0.7	-0.4	-0.1
Medication: Allopurinol	0.6	0.8	2.3	-1.0	-0.4	0.7	-0.1	1.5
Medication: Omeprazole	0.9	1.1	2.7	-0.7	-0.2	1.6	1.0	1.0
Medication: Seretide 50 evohaler	0.3	0.4	0.9	-0.4	-0.2	0.8	0.5	1.0
Mean time to correctly identify matches	0.2	0.3	1.0	-0.2	0.2	-1.0	-0.6	-0.4
Heart disease (mother)	1.2	1.4	3.6	1.0	1.3	-0.9	-0.4	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.0	1.7	-1.0	0.4	1.3	-0.8
Whole body fat mass	1.0	4.4	11.0	3.3	-1.1	-0.0	1.7	-2.6
Leg fat mass (right)	0.8	3.2	7.6	2.6	-0.0	-0.4	1.0	-2.8
Arm predicted mass (right)	1.3	6.7	13.1	1.0	-2.4	3.6	3.4	1.6
Pulse rate, automated reading	0.3	1.1	3.3	-1.3	-0.1	0.7	-0.4	1.8
Alcohol intake frequency.	1.0	2.3	5.7	1.0	0.6	2.1	2.4	0.1
Comparative height size at age 10	5.1	27.8	42.9	3.6	-6.5	5.8	6.2	3.3
Number of full sisters	0.5	0.6	1.3	1.1	0.1	-0.6	-0.1	-1.1
Suffer from ‘nerves’	0.8	1.3	3.9	-1.3	-0.7	0.7	0.2	2.0
Overall health rating	0.2	0.5	1.0	-1.0	-0.5	0.2	0.1	1.0
Chest pain or discomfort	1.1	1.6	3.1	-0.2	0.8	-1.8	-1.6	-1.3
Had major operations	0.4	0.4	1.4	-0.7	1.2	0.4	0.1	0.3
Age at last live birth	0.9	1.3	3.1	-0.1	0.1	-1.8	-1.8	-0.6
Family relationship satisfaction	0.8	1.0	2.0	0.6	0.3	-1.2	-1.1	-1.4
Leg pain on walking	0.5	0.7	1.7	-1.3	0.8	-0.3	-0.9	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.0	0.3	1.1	-1.2	-0.7	-1.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.4	-0.2	0.1	0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	-1.0	0.2	-0.8	-1.1	0.4
Medication: Aspirin	1.5	2.0	3.6	-1.2	0.8	1.8	1.0	1.9
Supplements: Vitamin C	0.1	0.2	0.4	0.1	0.6	-0.3	-0.2	-0.5
Knee pain experienced in last month	0.6	0.9	1.8	-1.2	-0.5	1.0	0.3	1.4
Hypertension (Self-reported)	0.9	2.4	3.9	-0.3	-1.6	2.0	1.4	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	1.7	0.1	-1.3	1.2	0.8	1.3
Illnesses of father: Heart disease	1.4	1.9	3.5	1.9	-1.4	1.1	1.7	-0.5
Illnesses of siblings: Diabetes	0.3	0.4	1.1	-0.6	0.1	-0.7	-1.1	-0.2
Smoking status: Previous	0.7	1.0	2.1	-1.0	0.9	-1.0	-1.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	5.6	0.6	-2.4	2.0	1.6	1.6
Whole body fat-free mass	1.4	8.1	13.2	1.7	-3.1	3.6	3.6	1.3
Leg fat-free mass (right)	1.3	6.8	11.0	2.0	-3.1	3.0	3.3	0.7
Arm fat percentage (left)	1.4	5.8	16.0	3.1	0.1	-1.8	0.2	-4.0
Average weekly red wine intake	0.5	0.7	1.9	0.6	-1.4	-1.0	-0.2	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	0.0	0.1	1.0	0.9	0.6
Mood swings	0.1	0.2	0.6	0.6	-0.7	-0.0	0.4	-0.1
Loneliness, isolation	1.0	1.3	2.8	1.3	-1.7	0.6	1.3	-0.1
Long-standing illness, disability or infirmity	1.6	2.4	4.4	-0.7	-1.3	1.7	1.5	2.1
Ever had bowel cancer screening	0.6	0.7	1.3	-0.9	1.0	0.7	0.1	1.2
Diabetes diagnosed by doctor	1.0	1.6	3.1	-1.8	0.2	1.4	0.6	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	3.2	0.4	-1.8	-0.3	0.5	0.0
Friendships satisfaction	1.2	1.5	2.8	0.6	-0.1	-1.7	-1.4	-1.5
Qualifications: nursing, teaching	3.1	4.8	10.0	3.2	-3.0	-1.0	0.8	-1.7
Commuting to job workplace: Walk	0.1	0.2	0.3	0.5	0.1	-0.5	0.1	-0.5
Eye problems/disorders: Cataract	2.7	3.1	6.3	1.9	-1.2	1.9	2.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.4	-0.1	0.1	-1.1	-1.2	-0.7
Medication for cholesterol	3.5	5.2	13.2	2.0	0.8	-2.6	-1.3	-3.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	-0.6	-1.1	0.2	-0.0	0.9
Back pain experienced in last month	0.0	0.1	0.1	-0.3	-0.2	0.2	0.3	0.2
Mineral and other dietary supplements	1.0	1.3	1.7	1.3	-1.2	-1.1	-0.8	-1.3
Breast cancer (self-reported)	0.6	0.7	2.4	-0.5	-1.5	0.0	-0.2	1.0
Asthma (self-reported)	0.4	0.8	2.1	-0.4	-1.4	-0.7	-0.8	0.5
Osteoporosis (self-reported)	1.0	1.2	2.6	-0.4	0.4	1.6	1.2	1.3
Osteoarthritis (self-reported)	1.2	1.5	3.3	-0.2	0.6	1.8	1.8	0.7
Medication: Aspirin	1.3	1.7	3.4	-0.7	-0.0	1.8	1.3	1.8
Medication: Gliclazide	0.5	0.5	1.7	-1.3	0.6	-0.1	-0.8	0.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.7	-0.6	0.2	1.3	1.0	1.3
Smoking status: Current	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.3	-0.7	0.3	0.5	-0.1	1.5
Whole body water mass	1.4	7.9	13.2	1.6	-3.0	3.6	3.6	1.4
Leg predicted mass (right)	1.3	6.9	11.0	2.0	-3.1	3.1	3.3	0.7
Arm fat mass (left)	0.7	3.1	7.1	2.7	-1.2	0.1	1.5	-2.1
Number of self-reported non-cancer illnesses	1.4	2.5	6.1	-2.1	-0.3	1.3	0.2	2.5
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.9	0.8	-0.3	-0.6	0.4
Miserableness	0.1	0.2	0.6	-0.4	0.2	-0.3	-0.7	-0.0
Guilty feelings	0.1	0.2	0.7	0.2	-0.8	0.2	0.3	-0.0
Wears glasses or contact lenses	0.0	0.1	0.2	0.2	0.2	0.4	0.0	0.0
Ever taken oral contraceptive pill	1.1	1.2	2.7	0.5	0.1	-1.6	-1.2	-1.2
Hearing aid user	2.1	2.4	3.5	1.1	-1.6	1.8	1.9	1.1
Mother’s age at death	1.1	1.4	4.5	2.1	-0.2	-0.0	0.6	-1.4
Financial situation satisfaction	0.3	0.3	1.3	0.4	-1.1	0.3	0.3	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	0.5	-0.1	-0.3	-0.5	-0.3
Commuting to job workplace: Public transport	0.5	0.6	1.6	-1.1	-0.3	0.3	-0.3	1.3
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.2	-0.4	-0.8	-0.2	-0.4
Medication: Blood pressure	0.4	0.7	2.0	-1.4	0.6	0.1	-0.6	0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.3	-0.0	0.4	0.3	0.4
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.0	-1.2	1.0	1.4	1.2	1.4
High cholesterol (Self-reported)	9.9	17.6	23.4	0.5	-4.8	4.8	4.8	4.3
Medication: Bendroflumethiazide	0.7	1.1	1.7	0.6	-1.3	1.2	1.3	0.6
Medication: Paracetamol	0.4	0.6	1.4	-1.2	0.9	0.6	0.1	0.8
Medication: Lisinopril	0.8	1.1	2.3	-1.0	-0.6	1.2	0.6	1.5
Medication: Atorvastatin	3.5	4.3	8.3	0.4	-1.5	2.9	2.6	2.0
Illnesses of father: High blood pressure	0.5	0.6	1.3	-0.9	0.5	-0.7	-1.1	-0.2
Alcohol drinker status: Never	1.7	2.0	5.7	-1.7	0.2	1.1	0.4	2.4
Ever smoked	0.3	0.5	1.1	-0.4	-0.2	1.0	0.5	1.1
Basal metabolic rate	1.3	7.4	12.6	2.2	-3.0	3.2	3.5	0.7
Leg fat percentage (left)	0.7	2.5	7.0	1.6	1.2	-1.3	0.1	-2.6
Arm fat-free mass (left)	1.4	6.9	12.6	1.0	-2.6	3.5	3.4	1.7
Number of operations (self-reported)	0.5	0.8	2.1	-0.6	0.6	1.5	0.6	1.0
Average weekly beer plus cider intake	2.4	3.5	9.2	-2.4	-1.0	1.3	-0.1	3.0
Irritability	0.6	0.9	2.3	-0.4	0.2	-1.5	-1.3	-0.7
Risk taking	0.2	0.2	0.7	0.8	0.1	0.6	0.4	-0.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	-0.3	0.3	-1.2	-1.1	-0.2
Fractured/broken bones in last 5 years	2.9	3.7	5.2	0.6	-2.3	2.3	2.3	1.6
Age started oral contraceptive pill	0.3	0.4	1.0	-0.7	-0.4	0.2	-0.3	1.0
Diastolic blood pressure, automated reading	0.6	1.7	3.9	1.0	-1.0	1.6	2.0	0.3
Ever depressed for a whole week	3.2	4.0	5.9	-1.4	2.3	-2.3	-2.4	-1.2
Unable to work because of sickness or disability	0.5	0.7	1.1	-1.0	0.7	0.8	0.3	1.0
Commuting to job workplace: Cycle	2.4	2.9	5.2	-1.3	1.9	-2.0	-2.3	-0.5
Myopia	1.0	1.5	2.7	0.0	1.0	-1.6	-1.6	-1.0
Vascular/heart problems diagnosed by doctor	0.9	2.6	4.7	0.3	1.4	-2.2	-1.6	-1.9
Cholesterol lowering medication	3.9	5.7	10.9	-0.2	-1.4	3.3	2.8	2.8
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.6	-0.2	-0.7	1.9	1.4	1.1
Pain experienced in last month	0.3	0.4	1.4	1.2	-0.3	-0.2	0.4	-0.7
Supplements: Calcium	0.0	0.0	0.1	0.2	0.4	0.1	0.0	0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	0.7	0.7	-0.5	0.0	-1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	0.1	0.1	0.9	1.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.2	0.3	-0.5	-0.3	-0.6
Heart disease (siblings)	1.0	1.2	2.8	0.1	-0.4	1.7	1.5	0.9
Alcohol drinker status: Previous	1.0	1.1	2.6	0.0	-0.0	1.6	1.3	1.1
Pack years of smoking	0.3	0.4	0.6	-0.0	-0.6	0.7	0.6	0.8
Impedance of whole body	0.8	4.2	7.7	2.8	-1.2	-2.4	-0.5	-2.4
Leg fat mass (left)	0.6	2.4	5.4	2.3	-0.1	-0.2	1.1	-2.3
Arm predicted mass (left)	1.3	6.4	11.4	1.2	-2.5	3.4	3.3	1.3