Best TWAS P=3.09e-18 · Best GWAS P=9.66e-66 conditioned to 1.4e-53
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NAB1 | 0.06 | 0.06 | lasso | 2 | 0.04 | 4.3e-06 | 8.9 | -8.7 | 3.1e-18 | -0.23 | 0.97 | 0.00 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | MFSD6 | 0.11 | 0.05 | bslmm | 368 | 0.07 | 1.0e-09 | 4.2 | 7.0 | 3.5e-12 | 0.15 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Testis | NAB1 | 0.14 | 0.06 | enet | 20 | 0.10 | 5.1e-05 | 3.2 | 6.4 | 1.9e-10 | 0.25 | 0.73 | 0.03 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | NAB1 | 0.05 | 0.02 | blup | 50 | 0.04 | 2.9e-03 | -2.3 | -6.2 | 5.4e-10 | -0.16 | 0.03 | 0.39 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | NAB1 | 0.15 | 0.00 | lasso | 3 | 0.00 | 2.5e-01 | 5.0 | 5.6 | 1.7e-08 | 0.13 | 0.08 | 0.04 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | INPP1 | 0.16 | 0.02 | lasso | 4 | 0.03 | 5.2e-02 | 4.0 | -5.5 | 3.8e-08 | -0.09 | 0.03 | 0.53 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM194B | 0.04 | 0.01 | blup | 41 | 0.02 | 3.8e-03 | 4.8 | 5.3 | 8.6e-08 | 0.13 | 0.00 | 0.94 | FALSE |
| 6 | YFS | Blood | TMEM194B | 0.01 | 0.00 | blup | 363 | 0.01 | 5.3e-04 | -3.7 | 5.2 | 2.4e-07 | 0.11 | 0.40 | 0.06 | FALSE |