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chr7:127,812,871-129,502,461

Best TWAS P=1.5e-44 · Best GWAS P=3.8e-45 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	IRF5	0.16	0.08	lasso	4	0.08	8.2e-05	10.97	11.0	5.7e-28	0.32	0.37	0.08	FALSE
2	GTEx	Colon Transverse	IRF5	0.21	0.22	lasso	4	0.22	8.0e-11	10.97	11.0	2.2e-28	0.31	1.00	0.00	FALSE
3	GTEx	Esophagus Mucosa	IRF5	0.13	0.14	lasso	4	0.13	4.6e-09	10.97	10.9	1.3e-27	0.29	0.99	0.00	FALSE
4	GTEx	Esophagus Muscularis	IRF5	0.21	0.12	lasso	5	0.11	3.9e-07	10.97	11.4	5.7e-30	0.32	0.85	0.02	FALSE
5	GTEx	Liver	RP11-286H14.6	0.34	0.28	enet	5	0.23	4.4e-07	-6.00	6.3	2.4e-10	0.21	0.81	0.05	TRUE
6	GTEx	Nerve Tibial	IRF5	0.13	0.09	enet	10	0.07	1.2e-05	10.97	11.1	9.0e-29	0.34	0.87	0.01	FALSE
7	GTEx	Pancreas	RP11-286H14.6	0.31	0.18	enet	8	0.14	2.2e-06	6.54	6.2	4.4e-10	0.21	0.74	0.09	FALSE
8	GTEx	Skin Sun Exposed Lower leg	IRF5	0.10	0.14	lasso	2	0.12	1.9e-10	10.97	11.3	1.0e-29	0.32	1.00	0.00	FALSE
9	GTEx	Thyroid	IRF5	0.14	0.10	enet	6	0.11	1.2e-08	10.97	6.4	1.4e-10	0.07	0.96	0.00	FALSE
10	GTEx	Whole Blood	TNPO3	0.11	0.11	lasso	2	0.12	4.9e-11	8.52	-5.7	1.5e-08	-0.42	1.00	0.00	FALSE
11	GTEx	Whole Blood	IRF5	0.17	0.06	lasso	4	0.09	1.2e-08	-8.06	10.5	1.0e-25	0.31	0.98	0.00	FALSE
12	METSIM	Adipose	IRF5	0.05	0.04	lasso	7	0.04	2.2e-06	10.97	11.9	1.2e-32	0.38	0.86	0.12	TRUE
13	NTR	Blood	TNPO3	0.03	0.01	enet	14	0.02	2.0e-06	-8.06	-7.2	7.9e-13	-0.18	0.97	0.00	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	IRF5	0.27	0.25	bslmm	336	0.25	7.1e-32	-8.17	9.3	1.8e-20	0.33	1.00	0.00	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	TSPAN33	0.04	0.00	bslmm	381	0.00	2.1e-01	-0.84	5.8	6.5e-09	0.36	0.03	0.08	FALSE
16	YFS	Blood	ATP6V1F	0.01	0.00	blup	327	0.00	1.3e-02	0.35	-7.7	1.7e-14	-0.38	0.12	0.40	TRUE
17	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IRF5	0.09	0.06	blup	30	0.08	1.8e-07	-8.06	11.4	5.7e-30	0.43	0.74	0.22	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	IRF5	0.10	0.09	lasso	4	0.08	1.6e-16	10.97	11.0	3.5e-28	0.30	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	IRF5	0.29	0.26	enet	6	0.29	3.1e-17	-11.46	12.1	1.5e-33	0.36	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Glioblastoma Multiforme	IRF5	0.18	0.02	enet	8	0.04	2.4e-02	-7.55	14.0	1.5e-44	0.76	0.00	0.80	TRUE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IRF5	0.14	0.12	enet	7	0.15	1.8e-16	11.51	9.8	9.3e-23	0.22	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IRF5	0.11	0.05	blup	30	0.07	2.2e-08	10.97	12.1	9.4e-34	0.40	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TSPAN33	0.04	0.00	blup	51	0.01	1.5e-02	7.39	-5.2	2.2e-07	-0.21	0.00	0.58	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IRF5	0.09	0.04	lasso	4	0.06	2.3e-04	10.97	10.7	1.3e-26	0.30	0.38	0.20	FALSE
25	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	IRF5	0.17	0.09	enet	6	0.15	1.8e-07	-8.68	11.7	1.2e-31	0.46	0.92	0.05	TRUE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	IRF5	0.18	0.11	enet	9	0.14	1.6e-15	10.97	11.7	8.0e-32	0.34	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IRF5	0.09	0.09	blup	30	0.13	3.1e-14	-11.46	7.2	4.2e-13	0.13	1.00	0.00	TRUE
28	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IRF5	0.14	0.15	enet	6	0.14	7.0e-10	-11.46	11.6	4.3e-31	0.36	1.00	0.00	TRUE
29	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IRF5	0.09	0.10	lasso	3	0.08	4.6e-04	-11.46	11.3	8.8e-30	0.34	0.06	0.18	TRUE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	IRF5	0.23	0.26	lasso	3	0.26	3.6e-27	-11.46	11.3	1.2e-29	0.34	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Rectum Adenocarcinoma	IRF5	0.41	0.13	blup	33	0.23	3.5e-06	-11.46	12.8	1.2e-37	0.46	0.19	0.19	FALSE
32	The Cancer Genome Atlas	Rectum Adenocarcinoma	TSPAN33	0.58	0.18	enet	13	0.20	1.5e-05	-5.24	5.8	8.8e-09	0.37	0.02	0.78	TRUE
33	The Cancer Genome Atlas	Skin Cutaneous Melanoma	IRF5	0.22	0.03	enet	11	0.10	1.3e-03	-1.98	8.6	7.4e-18	0.28	0.01	0.17	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	IRF5	0.22	0.21	enet	9	0.26	4.6e-25	-11.46	12.4	2.6e-35	0.43	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	IRF5	0.27	0.16	blup	30	0.22	9.7e-07	-11.46	6.6	3.1e-11	0.12	0.52	0.02	TRUE
36	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	KCP	0.33	0.00	blup	53	0.00	3.0e-01	-1.72	-8.3	8.1e-17	-0.33	0.01	0.12	FALSE