Hub : Genes

TNPO3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.1120	0.0480	8.3e-03	0.113	NA	0.103	NA	0.119	1.3e-10	NA	1.0e-09	NA	4.9e-11
2	NTR	Blood	0.0349	0.0122	2.4e-05	0.013	0.010	0.017	0.013	0.016	2.5e-05	2.1e-04	2.0e-06	3.0e-05	5.6e-06
3	ROSMAP	Brain Pre-frontal Cortex	0.1865	0.0494	4.2e-05	0.082	0.024	0.074	0.074	0.078	1.0e-10	3.6e-04	8.8e-10	8.3e-10	2.9e-10
4	YFS	Blood	0.3684	0.0366	0.0e+00	0.313	0.331	0.361	0.358	0.352	2.6e-105	2.9e-112	7.4e-125	7.9e-124	3.1e-121
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0570	0.0287	2.4e-03	0.026	0.018	0.029	NA	0.033	5.1e-04	3.2e-03	2.9e-04	NA	1.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	1.9	-0.3	-0.6	0.5	0.1	-1.4
Bipolar Disorder or Schizophrenia	0.8	2.0	4.7	0.8	1.0	1.2	1.5	-2.2
Depressed Affect (Nagel 2018)	0.8	1.6	4.3	-1.3	-2.1	-0.2	-1.2	0.8
Depression (Nagel 2018)	1.8	2.7	5.2	0.3	-1.2	-2.3	-2.1	1.5
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.3	-0.1	-0.1	-0.0	-0.3	0.5
Neuroticism (Nagel 2018)	0.5	1.2	4.9	-2.2	-0.7	0.5	-0.5	0.1
Schizophrenia (2018)	1.0	2.1	3.7	1.2	1.2	1.2	1.9	-1.7
Schizophrenia vs Biploar Disorder	0.7	1.0	2.8	1.7	-0.2	0.5	1.2	-0.6
Worry (Nagel 2018)	0.4	0.7	3.3	-1.8	0.3	0.5	-0.4	-0.2
Alzheimer’s Disease (in mother)	2.4	2.8	7.4	0.6	2.7	1.3	2.0	-0.8
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.4	0.1	-0.6	0.0	-0.5
Alzheimer’s Disease (including proxy)	2.6	3.8	6.9	1.1	2.4	1.5	2.6	-1.7
Crohns Disease (2017)	0.2	0.5	1.0	0.8	0.7	0.1	1.0	-0.3
Irritable Bowel Disease (IBD)	2.8	6.7	9.2	-0.1	-2.8	-3.0	-3.0	2.7
Ulcerative Colitis (UC)	9.5	17.9	28.5	-1.3	-5.0	-4.3	-5.3	4.0
Major Depression (MDD)	0.2	0.2	0.8	-0.1	0.9	-0.3	0.2	-0.4
Reaction Time	0.3	0.7	1.9	-1.4	0.3	0.6	-0.7	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	-0.2	0.9	1.0	0.6	-0.1
Breast Cancer	0.1	0.3	1.1	-0.0	1.1	-0.6	-0.4	-0.2
Ovarian Cancer	1.0	1.4	3.0	-0.7	-1.7	-0.7	-1.4	0.9
Prostate Cancer	2.3	3.2	4.2	0.4	-2.0	-1.9	-2.1	2.0
Age at First Birth	0.8	1.1	2.9	1.3	0.2	0.7	1.7	-0.6
Bipolar Disorder (2011)	0.2	0.2	1.0	-0.3	0.2	0.0	1.0	0.0
Body Mass Index (BMI) (2010)	2.4	3.3	4.6	-0.4	2.1	2.0	2.1	-1.8
Coronary Artery Disease (CAD)	0.1	0.2	0.5	-0.7	-0.1	0.1	-0.3	-0.5
Crohns Disease (2012)	1.1	1.8	3.7	1.8	1.9	0.2	1.3	-0.6
Mean Putamen Volume	1.0	1.1	2.2	1.5	1.4	-0.9	0.4	-0.5
Fasting Glucose	0.4	0.4	1.1	0.6	0.3	0.7	1.0	-0.2
HbA1C	0.1	0.1	0.1	-0.1	0.2	-0.3	-0.3	-0.2
HDL Cholesterol	0.2	0.4	1.7	1.3	0.0	-0.0	0.4	-0.3
LDL Cholesterol	0.3	0.5	2.0	-0.3	1.4	0.4	0.2	-0.6
Lupus	13.2	20.0	51.3	-5.7	-7.2	1.2	-3.6	1.5
Neuroticism (2016)	0.3	0.5	1.8	-1.4	0.8	0.1	-0.1	-0.3
Primary Biliary Cirrhosis	6.6	9.5	21.4	-3.8	-4.6	0.0	-3.1	1.3
Rheumatoid Arthritis	4.7	6.5	15.6	-1.8	-3.9	-0.9	-2.6	2.5
Schizophrenia (2014)	1.3	2.8	4.6	1.5	1.1	1.3	2.1	-2.1
Triglycerides	3.3	5.5	8.5	-0.9	2.5	2.6	2.2	-2.9
Type 2 Diabetes (T2D) (2012)	2.6	2.9	9.2	3.0	-0.1	-1.6	-0.8	1.5
Ulcerative Colitis	9.7	14.1	22.5	-0.0	-4.2	-3.9	-4.7	3.9
Blood Eosinophil Count	2.0	15.3	26.0	0.4	5.1	2.9	4.5	-4.6
Blood Platelet Count	1.1	12.5	24.7	3.0	3.6	2.1	5.0	-3.4
Blood Red Count	0.1	0.6	2.3	-0.5	1.5	0.5	-0.1	0.2
Blood White Count	0.4	2.8	6.1	-0.1	2.4	0.9	1.2	-2.5
Heel T-Score	1.0	7.9	12.6	0.7	3.0	3.2	3.5	-2.6
BMI	0.2	1.1	2.2	0.3	-0.5	-1.5	-1.3	1.1
Height	0.8	15.4	26.8	1.9	4.3	3.8	5.2	-3.7
Waist Hip Ratio (WHR)	0.1	0.3	0.8	-0.5	-0.7	-0.1	-0.2	-0.9
Systolic Blood Pressure	1.6	8.1	18.5	1.6	1.9	3.1	4.3	-2.5
Smoking Status	0.5	1.1	2.0	0.3	-1.4	-1.1	-1.3	0.8
Allergy or Eczema	0.4	1.0	2.8	1.7	0.9	-0.1	0.7	-1.0
Cardiovascular Disease	0.9	3.0	5.5	-0.8	0.5	2.4	1.8	-2.3
Hypothyroidism (self reported)	1.2	2.6	8.8	-3.0	-1.6	1.1	-0.8	-0.4
Respiratory disease	1.2	2.6	4.3	1.3	2.1	1.3	2.0	-1.3
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.2	-0.2	-0.1	0.1	-0.1
Lung FEV1/FVC ratio	0.0	0.2	0.4	-0.3	0.6	0.4	0.4	-0.5
Lung FVC	0.3	1.6	3.1	1.0	1.1	-1.5	-0.6	1.8
Neuroticism	0.4	1.0	3.4	-1.9	-0.1	1.0	0.1	-0.5
Chronotype (morning person)	2.2	5.0	9.0	1.2	2.7	1.6	2.2	-3.0
Hair Pigment	0.0	1.1	2.0	1.0	1.4	-1.1	-0.2	1.2
Tanning	0.1	1.0	2.5	-0.4	0.4	1.4	1.6	-0.5
Hand grip strength (left)	0.9	2.4	6.1	0.7	1.3	1.9	2.5	-0.5
Number of treatments/medications taken	0.7	1.3	4.1	-0.6	-2.0	-0.6	-1.2	0.4
Average weekly spirits intake	0.5	0.6	2.5	1.6	-0.0	-0.2	0.1	-0.5
Sensitivity / hurt feelings	0.9	1.5	5.0	-2.2	0.0	1.3	0.5	-0.7
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.2	0.1	-0.3	-1.8	-1.4	1.5
Hearing difficulty/problems: Yes	0.3	0.5	1.2	-1.0	-1.1	0.2	-0.4	-0.4
Relative age of first facial hair	1.3	2.7	4.0	-0.8	1.7	2.0	1.4	-2.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.0	-0.4	-1.0	-0.9	-1.0	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.0	-0.6	-0.3	0.1	-0.2
Ever had hysterectomy (womb removed)	2.2	2.4	4.2	0.8	1.9	1.2	1.5	-2.1
Systolic blood pressure, automated reading	0.8	2.3	4.9	1.4	0.6	1.5	2.2	-1.5
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	1.4	0.3	0.8	1.2	-1.2
Angina	0.4	0.5	1.5	1.2	-1.0	-0.2	0.1	-0.0
Medication for hormone replacement therapy	2.6	2.9	4.7	-0.5	1.0	2.2	2.1	-2.1
Vitamin and mineral supplements	1.2	1.6	2.3	-0.1	1.5	1.5	1.4	-1.3
Supplements: Zinc	0.4	0.4	0.9	0.3	0.1	0.8	0.6	-1.0
Medication: Co-codamol	0.4	0.5	1.2	-1.1	-0.3	-0.3	-0.9	0.1
Medication: Metformin	1.6	2.3	8.3	2.9	1.2	-0.5	0.9	-0.6
Diabetes (father)	0.4	0.5	1.1	0.7	0.5	0.8	1.1	0.2
Diabetes (mother)	0.4	0.5	1.8	-0.5	-0.4	0.4	0.4	-1.3
Severe depression (siblings)	0.1	0.1	0.2	0.0	0.0	-0.2	-0.3	0.4
Pack years adult smoking proportion	2.0	3.1	5.9	-0.5	-1.1	-2.1	-2.4	1.9
Impedance of leg (right)	0.1	0.6	1.5	-0.4	0.6	0.7	0.8	-1.2
Leg fat-free mass (left)	0.1	0.6	1.1	1.1	0.5	0.7	1.1	0.0
Trunk fat percentage	0.1	0.3	1.0	1.0	-0.3	-0.1	0.4	-0.7
Hand grip strength (right)	2.3	6.1	12.8	0.1	1.4	3.5	3.6	-1.9
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.6	0.1	-0.5	-0.2	0.6
Current tobacco smoking	2.8	4.5	7.6	0.3	-2.1	-2.6	-2.8	1.8
Average weekly fortified wine intake	1.1	1.3	2.2	1.2	0.4	-1.5	-0.7	1.4
Maternal smoking around birth	1.4	2.0	4.0	-0.2	-1.5	-1.3	-1.5	2.0
Fed-up feelings	1.3	2.4	7.7	-0.4	-2.8	-0.9	-1.5	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.4	-0.2	-1.0	-1.9	-1.6	1.6
Relative age voice broke	0.9	1.4	2.3	-0.0	1.5	1.1	1.1	-1.5
Taking other prescription medications	0.9	1.3	4.7	-0.4	-2.2	-0.7	-1.1	0.3
Age when periods started (menarche)	4.8	11.4	18.2	0.1	3.4	3.5	3.9	-4.3
Bilateral oophorectomy (both ovaries removed)	2.9	3.4	4.8	-0.1	2.0	1.9	2.1	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	0.5	0.9	0.3	0.8	-0.4
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.2	-0.9	-1.3	-1.1	-2.1	0.7
Qualifications: CSEs or equivalent	0.3	0.4	1.0	-1.0	0.8	0.1	-0.2	0.4
Serious illness, injury or assault to yourself	0.7	0.8	3.5	1.9	-0.2	-0.7	0.1	0.4
High blood pressure	1.4	3.9	7.1	0.4	1.0	2.3	2.7	-2.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.7	0.2	-0.5	-0.3	-0.5
Multivitamins +/- minerals	0.6	0.8	1.5	0.8	-0.7	-1.0	-0.6	1.2
Stomach or abdominal pain in last month	1.9	2.3	5.0	-2.2	0.3	1.7	0.7	-1.8
Supplements: Glucosamine	1.7	2.2	6.5	-0.9	-2.6	-0.7	-1.3	1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.1	-1.0	1.0	1.0	0.4	-0.4
Medication: Atenolol	0.7	0.9	1.9	-1.4	0.4	0.8	0.4	-1.2
Medication: Levothyroxine sodium	0.5	0.8	1.7	-0.4	-1.3	-0.5	-1.0	1.0
Sitting height	0.4	3.0	5.2	1.9	1.9	1.1	2.3	-1.2
Chronic bronchitis/emphysema (father)	1.3	1.6	3.1	0.6	-1.8	-1.4	-1.0	1.3
High blood pressure (mother)	2.8	4.0	10.9	3.3	2.0	0.3	1.9	-1.1
Body mass index (BMI)	0.4	1.6	2.3	0.3	-1.5	-1.4	-1.4	1.2
Impedance of leg (left)	0.2	1.0	2.1	-0.6	0.9	1.0	0.9	-1.5
Leg predicted mass (left)	0.1	0.5	1.0	1.0	0.4	0.6	1.0	0.1
Trunk fat mass	0.1	0.6	1.6	1.2	0.1	0.2	0.8	-0.7
Waist circumference	0.1	0.3	0.5	0.7	-0.7	-0.2	0.2	-0.4
Number of incorrect matches in round	0.6	1.1	1.5	0.7	-1.2	-1.0	-1.0	1.1
Past tobacco smoking	0.4	0.8	3.0	0.4	1.7	-0.7	-0.1	0.5
Alcohol usually taken with meals	2.8	4.6	7.5	-0.9	2.1	2.7	2.5	-2.0
Nervous feelings	0.2	0.4	1.0	-1.0	0.8	0.6	-0.0	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.1	0.4	-0.0	-0.3	0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.1	-0.3	0.5	0.6	-0.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	0.8	0.1	-0.7	-0.3	-0.4
Had menopause	0.4	0.5	1.0	0.8	-1.0	-0.8	-0.5	0.4
Had other major operations	0.5	0.7	1.1	-0.4	1.0	0.9	0.6	-1.0
Forced vital capacity (FVC)	0.7	2.8	8.2	1.1	2.9	1.1	1.6	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.7	1.6	0.8	-0.2	0.9	-0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	-0.5	-0.8	-1.5	-1.4	0.8
Qualifications: None of the above	0.6	1.2	3.5	-0.0	-1.9	-1.0	-1.1	0.8
Financial difficulties in last 2 years	0.5	0.6	2.8	0.2	1.7	0.2	0.5	0.1
Mouth/teeth dental problems	7.1	10.9	22.1	1.3	4.7	2.8	4.2	-2.4
Heart attack	2.3	2.9	5.2	1.3	-0.7	-2.3	-1.8	2.1
Allergy	0.1	0.3	0.8	-0.9	-0.4	0.7	0.3	-0.1
Pain all over the body in last month	4.1	4.4	7.2	1.0	-1.2	-2.7	-2.5	2.5
Diabetes (self-reported)	0.3	0.5	1.9	1.4	-0.0	-0.7	0.0	-0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.0	0.3	1.2	0.8	1.1	-1.7
Medication: Ramipril	3.8	4.9	8.3	0.9	1.6	2.3	2.9	-2.7
Medication: Simvastatin	0.3	0.5	1.6	0.1	-0.4	0.5	0.7	-1.3
Fluid intelligence score	0.4	0.9	1.9	0.0	1.1	0.9	0.6	-1.4
Illnesses of siblings	0.4	0.6	2.2	-0.8	1.5	0.0	0.0	-0.1
Neuroticism score	0.2	0.4	1.6	-1.3	-0.2	0.3	-0.5	0.3
Weight	0.0	0.2	0.4	0.6	-0.1	0.4	0.6	-0.2
Impedance of arm (right)	1.2	5.7	10.5	0.3	2.2	2.3	2.8	-3.2
Arm fat percentage (right)	0.1	0.3	0.7	0.8	-0.3	-0.8	-0.3	0.1
Trunk fat-free mass	0.1	0.5	1.1	1.1	0.6	0.4	0.8	0.3
Hip circumference	0.1	0.4	0.7	0.7	0.3	0.7	0.8	-0.7
Time employed in main current job	0.4	0.4	2.0	-1.4	-0.1	0.4	0.0	-0.1
Alcohol intake versus 10 years previously	0.3	0.5	1.2	0.4	-1.1	-0.6	-0.6	0.5
Father’s age at death	0.9	1.1	2.8	-0.5	1.7	0.9	0.9	-1.1
Worrier / anxious feelings	0.4	0.7	2.6	-1.6	0.8	0.6	0.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.2	-1.8	-1.5	-0.4	-1.1	0.9
Falls in the last year	0.2	0.2	0.5	-0.6	0.7	-0.3	-0.3	0.3
Hair/balding pattern: Pattern 3	0.5	0.8	2.6	-1.6	0.8	0.7	-0.0	0.2
Number of live births	0.2	0.3	0.4	0.6	-0.3	-0.7	-0.3	0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	7.1	0.6	2.7	1.1	1.5	-1.2
Pulse rate	1.2	2.1	5.5	-1.4	0.4	-0.9	-1.3	2.3
Happiness	1.2	1.4	5.2	0.5	2.3	-0.3	1.0	0.7
Noisy workplace	0.7	0.9	2.0	-1.4	-0.9	0.8	0.1	0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.2	-1.7	2.0	1.0	0.5	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.3	1.2	-0.1	-1.5	-0.7	0.9
Mouth/teeth dental problems: Dentures	2.0	3.4	5.7	0.6	-2.4	-2.1	-2.4	0.9
Asthma	1.2	2.3	5.1	1.0	2.3	1.1	2.0	-0.8
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.5	8.2	-2.3	-2.9	-0.5	-1.7	1.0
Medication: Cholesterol lowering	0.1	0.2	0.4	0.6	-0.5	0.2	0.2	-0.6
Depression (self-reported)	0.4	0.5	1.3	-1.1	0.8	0.0	-0.1	-0.8
Medication: Lansoprazole	0.4	0.4	1.2	0.9	-1.1	-0.2	-0.3	0.3
Prospective memory result	0.0	0.0	0.0	0.0	-0.2	0.0	0.2	0.1
Lung cancer (father)	0.6	0.7	2.1	1.5	-0.3	-1.0	-0.3	0.3
Illnesses of mother	0.9	1.2	1.8	-1.4	-1.1	-0.2	-1.3	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	8.3	0.4	2.9	0.9	1.2	-1.0
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	-1.2	0.8	-0.1	-0.5	1.1
Impedance of arm (left)	1.0	4.5	8.4	0.0	1.7	2.3	2.5	-2.9
Arm fat mass (right)	0.1	0.3	0.8	0.9	-0.4	-0.7	-0.2	0.3
Trunk predicted mass	0.1	0.5	1.1	1.0	0.5	0.4	0.8	0.3
Standing height	1.1	11.0	18.9	1.0	3.0	3.8	4.3	-3.4
Length of working week for main job	0.9	1.0	2.5	-0.6	0.4	1.1	1.6	-0.9
Exposure to tobacco smoke at home	1.0	1.2	3.3	-1.8	-0.6	-0.5	-1.2	0.7
Breastfed as a baby	0.2	0.2	0.3	-0.6	0.5	0.5	0.5	0.4
Tense / ‘highly strung’	0.4	0.6	2.2	-1.5	0.3	0.7	0.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.6	-0.4	-0.2	-1.9	-1.6	1.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	0.8	0.9	-0.1	0.3	-0.3
Birth weight of first child	1.0	1.8	3.8	-0.0	0.8	1.5	1.6	-1.9
Peak expiratory flow (PEF)	0.4	1.0	1.8	-0.2	0.8	1.2	1.3	-1.0
Pulse wave reflection index	0.3	0.4	0.7	-0.8	-0.0	-0.3	-0.8	0.8
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.2	-0.2	-1.2	-1.2	-1.5	0.9
Loud music exposure frequency	0.2	0.2	0.5	0.7	0.3	-0.5	-0.1	0.5
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	6.2	-0.9	2.5	1.9	1.6	-2.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	-1.1	-0.9	0.1	-0.2	-0.2
Blood clot in the leg (DVT)	1.5	1.9	3.5	-0.2	-1.2	-1.3	-1.7	1.9
Medication: Paracetamol	0.9	1.5	2.2	-1.4	-1.2	-0.6	-1.3	1.5
Headache pain in last month	0.4	0.6	2.4	-1.5	-0.3	0.7	-0.1	0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.3	0.4	-0.6	-0.5	0.8
Glaucoma (self-reported)	2.9	3.4	4.8	-1.6	1.3	2.2	1.9	-2.1
Gout (self-reported)	2.5	3.4	7.5	-1.3	-2.7	-1.0	-2.4	1.1
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.7	-1.9	-1.6	-0.2	-1.3	0.8
Medication: Amlodipine	0.8	1.2	1.6	-1.2	0.6	1.2	1.0	-1.3
Medication: Ventolin 100micrograms inhaler	1.5	2.0	3.1	0.4	1.8	1.2	1.5	-1.6
Birth weight	1.2	2.5	3.9	-1.2	1.7	2.0	1.0	-1.8
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.0	0.7	-0.8	-1.4	-1.0	0.6
High blood pressure (siblings)	1.0	1.4	3.1	0.0	-0.5	1.8	1.3	-1.4
Forced vital capacity (FVC), Best measure	0.7	2.5	8.5	0.8	2.9	0.9	1.3	-0.7
Body fat percentage	0.1	0.3	0.7	0.8	-0.5	-0.7	-0.3	-0.1
Leg fat percentage (right)	0.2	0.7	1.5	0.8	-0.7	-1.2	-0.7	0.6
Arm fat-free mass (right)	0.1	0.4	0.9	1.0	-0.1	0.1	0.4	0.9
Exposure to tobacco smoke outside home	1.5	2.0	3.5	0.9	1.1	1.2	1.9	-1.8
Comparative body size at age 10	1.8	4.9	9.4	0.3	-1.8	-2.4	-2.5	3.1
Number of full brothers	0.3	0.4	1.4	0.2	-1.2	-0.2	0.4	0.6
Worry too long after embarrassment	1.7	2.9	4.5	-0.0	2.1	1.8	2.1	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.7	-0.8	0.8	-0.2	-0.3	0.4
Wheeze or whistling in the chest in last year	0.7	1.2	2.4	0.1	-1.5	-1.3	-1.2	0.7
Number of children fathered	0.3	0.3	0.8	-0.0	-0.3	0.8	0.9	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.1	-0.2	0.1	-0.0	0.1
Age at first live birth	0.0	0.1	0.1	0.2	-0.4	-0.0	-0.2	-0.3
Pulse wave peak to peak time	0.8	0.9	2.0	1.2	-0.4	0.4	0.9	-1.4
Health satisfaction	0.4	0.6	1.9	0.8	1.4	-0.3	0.5	-0.2
Shortness of breath walking on level ground	0.0	0.1	0.1	-0.4	0.3	0.2	0.1	0.2
Qualifications: College or University degree	0.3	1.0	3.5	-0.1	1.9	0.5	0.9	-0.5
Eye problems/disorders: None of the above	2.6	3.0	5.6	0.7	-0.9	-2.4	-2.3	1.7
Mouth/teeth dental problems: Loose teeth	4.1	4.9	9.3	0.3	-1.4	-2.3	-2.8	3.0
Emphysema/chronic bronchitis	1.2	1.4	3.7	-0.5	1.2	0.9	0.8	-1.9
Medication for pain relief, constipation, heartburn	1.7	2.9	7.6	1.0	2.8	1.1	1.8	-1.1
Neck or shoulder pain in last month	2.0	2.9	3.8	-0.5	-2.0	-1.8	-1.9	1.8
Medication: Blood pressure	0.9	1.6	3.2	-0.1	0.8	1.4	1.4	-1.8
Angina (self-reported)	0.4	0.5	1.7	1.3	-0.8	-0.3	0.0	0.0
Migraine (self-reported)	0.6	0.8	1.4	0.4	-0.6	-1.1	-1.2	0.9
Medication: Ibuprofen	1.5	1.8	4.6	-1.9	-2.1	0.1	-1.0	0.3
Medication: Allopurinol	2.8	3.7	6.5	-1.9	-2.3	-1.2	-2.6	1.3
Medication: Omeprazole	0.5	0.6	2.3	0.4	-1.5	-0.3	-0.4	0.2
Medication: Seretide 50 evohaler	0.3	0.3	1.0	0.1	-0.4	-0.4	-0.5	1.0
Mean time to correctly identify matches	0.1	0.2	0.5	-0.5	0.3	0.1	-0.7	0.5
Heart disease (mother)	0.8	1.0	2.4	-1.6	0.3	0.9	1.0	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.6	-0.4	0.8	1.3	1.1	-1.2
Whole body fat mass	0.1	0.3	1.0	1.0	-0.5	-0.4	0.1	-0.1
Leg fat mass (right)	0.1	0.5	0.7	0.8	-0.7	-0.8	-0.4	0.6
Arm predicted mass (right)	0.1	0.4	1.1	1.0	0.0	-0.1	0.3	1.0
Pulse rate, automated reading	1.4	4.4	8.6	0.7	-0.2	-2.8	-2.3	2.9
Alcohol intake frequency.	0.3	0.6	1.6	-1.3	-0.7	-0.1	-0.8	0.6
Comparative height size at age 10	0.1	0.5	1.2	0.1	1.1	0.9	0.7	-0.3
Number of full sisters	0.2	0.3	1.1	0.3	0.4	-0.2	0.4	1.0
Suffer from ‘nerves’	1.1	1.7	3.1	-1.3	-1.4	-0.7	-1.8	1.0
Overall health rating	2.1	4.5	8.1	-1.2	-2.4	-1.9	-2.9	1.9
Chest pain or discomfort	0.5	0.7	1.4	-0.0	-0.4	-1.1	-1.2	0.9
Had major operations	0.2	0.2	0.6	-0.4	-0.8	-0.2	-0.6	0.0
Age at last live birth	0.4	0.5	1.5	-0.4	-1.2	-0.2	-0.7	0.6
Family relationship satisfaction	0.4	0.5	1.2	-0.6	0.6	-0.8	-0.3	1.1
Leg pain on walking	0.5	0.6	1.1	-0.6	-0.6	-0.8	-0.9	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.5	0.1	0.7	1.0	1.1	-1.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	0.6	0.8	0.1	0.6	-0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.5	-1.0	-1.6	0.8	0.0	-0.1
Medication: Aspirin	0.5	0.6	1.2	0.6	0.2	0.7	0.9	-1.1
Supplements: Vitamin C	1.1	1.3	2.9	-0.7	0.4	1.5	0.9	-1.7
Knee pain experienced in last month	1.5	2.3	7.1	-2.7	-1.7	0.3	-1.1	0.1
Hypertension (Self-reported)	1.4	3.8	7.6	0.8	0.7	2.2	2.8	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.6	-0.1	-1.6	0.6	0.3	-0.4
Illnesses of father: Heart disease	0.3	0.5	1.8	-1.3	-0.7	0.0	-0.4	-0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.8	-0.9	-0.4	-0.1	-0.9	0.3
Smoking status: Previous	0.6	0.9	2.4	-0.1	-0.5	1.5	1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.9	0.3	1.7	0.9	1.3	-0.3
Whole body fat-free mass	0.1	0.5	1.4	1.2	0.4	0.4	0.9	0.3
Leg fat-free mass (right)	0.1	0.6	1.2	1.0	0.6	0.8	1.1	-0.1
Arm fat percentage (left)	0.1	0.3	0.6	0.6	-0.4	-0.8	-0.3	0.2
Average weekly red wine intake	1.3	1.9	3.4	0.6	1.3	1.6	1.8	-1.3
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.1	1.5	-0.9	-0.2	0.2	0.5
Mood swings	0.2	0.4	0.8	-0.9	-0.7	0.8	0.2	0.2
Loneliness, isolation	1.3	1.8	3.2	-1.2	-1.8	-0.6	-1.2	1.5
Long-standing illness, disability or infirmity	0.8	1.2	2.2	-0.1	-1.5	-1.1	-1.4	0.5
Ever had bowel cancer screening	0.3	0.3	0.7	-0.7	-0.8	0.1	-0.2	-0.6
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.8	-0.2	-0.7	-0.2	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.2	-0.3	0.4	0.4	0.4	-0.5
Friendships satisfaction	1.8	2.3	5.6	0.5	-0.1	-1.9	-1.3	2.4
Qualifications: nursing, teaching	0.3	0.5	2.4	-0.0	1.6	0.1	-0.1	0.0
Commuting to job workplace: Walk	0.7	0.8	1.4	-1.2	0.6	1.0	0.0	-1.1
Eye problems/disorders: Cataract	1.7	1.9	4.0	1.4	0.8	1.4	2.0	-1.1
Mouth/teeth dental problems: Mouth ulcers	5.5	8.7	16.4	-2.5	-4.1	-1.2	-3.5	2.7
Medication for cholesterol	1.3	2.0	3.8	0.1	-1.1	-1.5	-1.9	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	-1.0	-0.7	0.4	-0.1	-1.5
Back pain experienced in last month	1.0	1.5	3.3	-1.8	-1.7	-0.2	-1.0	0.3
Mineral and other dietary supplements	0.4	0.5	1.8	0.6	1.3	-0.5	-0.0	0.2
Breast cancer (self-reported)	1.2	1.5	5.7	-0.9	-2.4	-0.3	-0.8	0.1
Asthma (self-reported)	1.0	1.9	4.8	1.2	2.2	0.7	1.7	-0.5
Osteoporosis (self-reported)	0.3	0.4	0.7	0.1	-0.7	-0.8	-0.5	0.6
Osteoarthritis (self-reported)	0.8	1.1	3.7	-1.9	0.3	0.4	-0.3	-1.1
Medication: Aspirin	0.7	0.9	1.6	0.9	0.4	0.9	1.3	-1.1
Medication: Gliclazide	0.6	0.6	2.0	1.4	-0.4	-0.9	0.3	0.4
Illnesses of father: None of the above (group 1)	1.2	1.4	4.8	2.2	0.9	0.1	1.0	-0.7
Smoking status: Current	2.4	3.8	6.2	0.4	-2.0	-2.4	-2.5	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	1.0	4.2	-0.7	2.1	0.1	-0.0	0.0
Whole body water mass	0.1	0.5	1.5	1.2	0.4	0.3	0.8	0.3
Leg predicted mass (right)	0.1	0.6	1.2	1.0	0.6	0.8	1.1	-0.1
Arm fat mass (left)	0.1	0.4	0.8	0.9	-0.6	-0.7	-0.3	0.4
Number of self-reported non-cancer illnesses	0.6	1.1	2.9	-1.1	-1.7	-0.2	-1.0	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.6	-0.4	0.8	-0.3	-0.4	0.2
Miserableness	0.7	1.3	4.3	-2.1	-0.6	1.0	0.1	-0.7
Guilty feelings	0.1	0.2	0.7	-0.2	0.8	0.2	-0.1	0.4
Wears glasses or contact lenses	0.8	0.9	3.3	0.6	0.2	0.6	0.7	-1.8
Ever taken oral contraceptive pill	0.5	0.5	1.5	0.1	0.5	-0.8	-0.6	1.2
Hearing aid user	0.4	0.4	1.5	-1.2	0.0	-0.3	-0.5	0.5
Mother’s age at death	0.8	1.0	3.1	1.8	1.2	-0.5	0.5	-0.4
Financial situation satisfaction	0.5	0.6	2.1	0.6	1.4	-0.2	0.6	0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	0.6	-1.0	-0.7	-0.2	-1.1
Commuting to job workplace: Public transport	0.7	0.9	1.7	-0.7	-0.7	-1.2	-1.3	0.5
Eye problems/disorders: Glaucoma	2.2	2.6	4.0	-2.0	1.0	1.9	1.4	-1.5
Medication: Blood pressure	0.8	1.5	2.9	0.9	1.1	1.0	1.7	-1.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	-0.5	-0.9	-0.1	-0.7	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.3	-0.4	0.3	0.2	-0.4
High cholesterol (Self-reported)	0.3	0.5	1.9	-0.4	-0.4	0.5	0.3	-1.4
Medication: Bendroflumethiazide	0.6	0.8	1.9	0.1	0.9	1.1	1.4	-0.5
Medication: Paracetamol	1.1	1.7	2.7	-0.6	-1.2	-1.2	-1.6	1.6
Medication: Lisinopril	0.1	0.1	0.4	-0.6	0.2	-0.1	-0.4	-0.1
Medication: Atorvastatin	0.2	0.2	0.6	-0.4	-0.8	0.3	-0.2	0.3
Illnesses of father: High blood pressure	1.0	1.3	2.2	-0.7	1.5	1.5	1.0	-0.6
Alcohol drinker status: Never	0.4	0.5	1.6	-1.3	-0.5	0.6	-0.3	-0.1
Ever smoked	0.5	0.8	3.3	-0.8	-1.8	0.1	-0.5	-0.2
Basal metabolic rate	0.1	0.4	1.2	1.1	0.2	0.3	0.7	0.4
Leg fat percentage (left)	0.2	0.6	1.2	0.4	-0.7	-1.1	-0.8	0.6
Arm fat-free mass (left)	0.1	0.4	1.3	1.1	0.0	0.0	0.5	0.7
Number of operations (self-reported)	0.4	0.6	0.9	0.9	-0.9	-0.7	-0.9	-0.0
Average weekly beer plus cider intake	0.1	0.1	0.2	0.1	-0.4	-0.1	-0.4	0.4
Irritability	2.1	3.5	6.5	-1.9	-1.8	-1.3	-2.5	1.6
Risk taking	0.3	0.4	1.3	-0.1	0.4	0.5	0.7	-1.1
Ever had prostate specific antigen (PSA) test	2.3	2.7	5.6	-0.7	0.9	2.0	1.6	-2.4
Fractured/broken bones in last 5 years	1.9	2.4	4.4	-0.1	-0.8	-2.1	-1.9	1.8
Age started oral contraceptive pill	0.1	0.1	0.3	0.3	0.1	0.2	0.2	-0.5
Diastolic blood pressure, automated reading	0.1	0.4	1.0	0.7	0.7	0.4	1.0	0.1
Ever depressed for a whole week	0.3	0.3	0.8	-0.2	0.0	-0.8	-0.4	0.9
Unable to work because of sickness or disability	0.6	0.8	2.6	1.6	1.1	0.1	0.5	0.2
Commuting to job workplace: Cycle	1.5	1.8	4.2	0.7	-0.3	-1.7	-1.1	2.0
Myopia	0.2	0.4	0.6	-0.3	0.7	0.7	0.7	-0.4
Vascular/heart problems diagnosed by doctor	1.0	2.6	5.0	-0.5	-0.3	-1.9	-2.2	2.1
Cholesterol lowering medication	0.2	0.3	0.5	0.6	0.4	0.1	0.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.1	0.2	-1.8	-0.4	-0.6	0.2
Pain experienced in last month	1.0	1.7	4.6	2.1	1.1	0.2	1.0	-1.1
Supplements: Calcium	2.2	2.4	3.9	0.7	-1.2	-1.8	-1.7	2.0
Basal cell carcinoma (self-reported)	0.5	0.6	2.7	1.6	-0.5	-0.4	0.1	0.2
Heart attack/myocardial infarction (self-reported)	2.2	2.8	5.1	1.3	-0.6	-2.3	-1.7	2.0
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	3.9	-0.2	-1.3	-1.4	-1.8	2.0
Heart disease (siblings)	1.8	2.2	3.2	0.8	-1.5	-1.8	-1.7	1.5
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.4	-0.2	0.5	0.3	-0.4
Pack years of smoking	1.8	2.6	4.8	-0.7	-1.3	-1.8	-2.2	1.6
Impedance of whole body	0.6	3.3	6.7	-0.3	1.6	1.9	1.9	-2.6
Leg fat mass (left)	0.1	0.3	0.4	0.5	-0.6	-0.6	-0.4	0.6
Arm predicted mass (left)	0.1	0.5	1.6	1.3	-0.0	-0.2	0.3	0.8