Best TWAS P=2.02e-11 · Best GWAS P=1.01e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | MED19 | 0.11 | 0.04 | enet | 26 | 0.10 | 7.5e-06 | 6.3 | -5.5 | 3.9e-08 | -0.77 | 0.02 | 0.92 | FALSE |
| 2 | GTEx | Esophagus Mucosa | MED19 | 0.14 | 0.07 | lasso | 4 | 0.11 | 5.9e-08 | 3.0 | -5.4 | 5.6e-08 | -0.78 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | MED19 | 0.11 | 0.14 | lasso | 1 | 0.14 | 6.0e-07 | 6.3 | -6.3 | 3.9e-10 | -0.93 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Pancreas | MED19 | 0.10 | 0.08 | lasso | 3 | 0.02 | 5.0e-02 | 6.4 | -6.4 | 1.9e-10 | -0.95 | 0.02 | 0.87 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ZDHHC5 | 0.05 | 0.03 | lasso | 8 | 0.02 | 6.2e-03 | 6.3 | 6.3 | 3.2e-10 | 0.89 | 0.05 | 0.94 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | MED19 | 0.15 | 0.11 | lasso | 7 | 0.09 | 1.3e-07 | 6.3 | -6.3 | 2.4e-10 | -0.94 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Stomach | MED19 | 0.10 | 0.04 | lasso | 7 | 0.09 | 6.8e-05 | 6.3 | -5.8 | 8.2e-09 | -0.85 | 0.02 | 0.91 | FALSE |
| 8 | NTR | Blood | SERPING1 | 0.01 | 0.00 | blup | 399 | 0.00 | 2.9e-02 | -4.5 | 5.6 | 1.6e-08 | 0.67 | 0.08 | 0.76 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | ZDHHC5 | 0.05 | 0.02 | blup | 401 | 0.03 | 2.0e-04 | 6.5 | -6.6 | 3.7e-11 | -0.75 | 0.01 | 0.96 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | AP000662.4 | 0.05 | 0.01 | enet | 17 | 0.02 | 3.8e-04 | 3.0 | -5.4 | 7.5e-08 | -0.59 | 0.12 | 0.86 | FALSE |
| 11 | YFS | Blood | SERPING1 | 0.04 | 0.04 | lasso | 6 | 0.04 | 1.2e-12 | 5.2 | 5.5 | 4.6e-08 | 0.68 | 0.61 | 0.39 | FALSE |
| 12 | YFS | Blood | ZDHHC5 | 0.06 | 0.07 | enet | 20 | 0.07 | 1.2e-22 | 6.3 | 6.7 | 2.0e-11 | 0.95 | 0.01 | 0.99 | TRUE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MED19 | 0.05 | 0.03 | enet | 7 | 0.05 | 1.3e-10 | 6.3 | -5.4 | 7.9e-08 | -0.80 | 0.01 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMX2 | 0.07 | 0.06 | lasso | 1 | 0.05 | 5.0e-04 | 6.3 | 6.3 | 3.7e-10 | 0.96 | 0.00 | 0.91 | FALSE |
| 15 | The Cancer Genome Atlas | Esophageal Carcinoma | MED19 | 0.10 | 0.06 | lasso | 4 | 0.02 | 5.4e-02 | 6.3 | -6.3 | 2.3e-10 | -0.95 | 0.00 | 0.85 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MED19 | 0.03 | 0.01 | lasso | 2 | 0.02 | 1.9e-03 | 6.3 | -5.1 | 3.0e-07 | -0.78 | 0.00 | 0.69 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | MED19 | 0.05 | 0.02 | blup | 26 | 0.03 | 6.0e-05 | 6.3 | -5.6 | 2.2e-08 | -0.81 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED19 | 0.03 | 0.02 | lasso | 1 | 0.01 | 1.8e-02 | 6.3 | -6.3 | 3.9e-10 | -0.93 | 0.00 | 0.86 | FALSE |