[Hub]/) : Traits : Neuroticism (Nagel 2018) :

chr11:56,666,189-58,178,587

Best TWAS P=2.02e-11 · Best GWAS P=1.01e-10 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Breast Mammary Tissue MED19 0.11 0.04 enet 26 0.10 7.5e-06 6.3 -5.5 3.9e-08 -0.77 0.02 0.92 FALSE
2 GTEx Esophagus Mucosa MED19 0.14 0.07 lasso 4 0.11 5.9e-08 3.0 -5.4 5.6e-08 -0.78 0.03 0.97 FALSE
3 GTEx Heart Atrial Appendage MED19 0.11 0.14 lasso 1 0.14 6.0e-07 6.3 -6.3 3.9e-10 -0.93 0.02 0.98 FALSE
4 GTEx Pancreas MED19 0.10 0.08 lasso 3 0.02 5.0e-02 6.4 -6.4 1.9e-10 -0.95 0.02 0.87 FALSE
5 GTEx Skin Sun Exposed Lower leg ZDHHC5 0.05 0.03 lasso 8 0.02 6.2e-03 6.3 6.3 3.2e-10 0.89 0.05 0.94 FALSE
6 GTEx Skin Sun Exposed Lower leg MED19 0.15 0.11 lasso 7 0.09 1.3e-07 6.3 -6.3 2.4e-10 -0.94 0.02 0.98 FALSE
7 GTEx Stomach MED19 0.10 0.04 lasso 7 0.09 6.8e-05 6.3 -5.8 8.2e-09 -0.85 0.02 0.91 FALSE
8 NTR Blood SERPING1 0.01 0.00 blup 399 0.00 2.9e-02 -4.5 5.6 1.6e-08 0.67 0.08 0.76 FALSE
9 ROSMAP Brain Pre-frontal Cortex ZDHHC5 0.05 0.02 blup 401 0.03 2.0e-04 6.5 -6.6 3.7e-11 -0.75 0.01 0.96 FALSE
10 ROSMAP Brain Pre-frontal Cortex AP000662.4 0.05 0.01 enet 17 0.02 3.8e-04 3.0 -5.4 7.5e-08 -0.59 0.12 0.86 FALSE
11 YFS Blood SERPING1 0.04 0.04 lasso 6 0.04 1.2e-12 5.2 5.5 4.6e-08 0.68 0.61 0.39 FALSE
12 YFS Blood ZDHHC5 0.06 0.07 enet 20 0.07 1.2e-22 6.3 6.7 2.0e-11 0.95 0.01 0.99 TRUE
13 The Cancer Genome Atlas Breast Invasive Carcinoma MED19 0.05 0.03 enet 7 0.05 1.3e-10 6.3 -5.4 7.9e-08 -0.80 0.01 0.99 FALSE
14 The Cancer Genome Atlas Colon Adenocarcinoma TMX2 0.07 0.06 lasso 1 0.05 5.0e-04 6.3 6.3 3.7e-10 0.96 0.00 0.91 FALSE
15 The Cancer Genome Atlas Esophageal Carcinoma MED19 0.10 0.06 lasso 4 0.02 5.4e-02 6.3 -6.3 2.3e-10 -0.95 0.00 0.85 FALSE
16 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MED19 0.03 0.01 lasso 2 0.02 1.9e-03 6.3 -5.1 3.0e-07 -0.78 0.00 0.69 FALSE
17 The Cancer Genome Atlas Lung Adenocarcinoma MED19 0.05 0.02 blup 26 0.03 6.0e-05 6.3 -5.6 2.2e-08 -0.81 0.01 0.99 FALSE
18 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MED19 0.03 0.02 lasso 1 0.01 1.8e-02 6.3 -6.3 3.9e-10 -0.93 0.00 0.86 FALSE