Hub : Genes

SERPING1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hippocampus	0.2269	0.0997	4.0e-03	0.131	NA	0.048	NA	0.073	5.8e-04	NA	2.9e-02	NA	8.7e-03
2	GTEx	Pancreas	0.1070	0.0460	6.0e-03	0.012	NA	0.001	NA	-0.006	1.0e-01	NA	2.9e-01	NA	7.7e-01
3	NTR	Blood	0.0099	0.0046	3.5e-03	0.004	0.003	0.001	0.002	0.001	1.5e-02	2.9e-02	1.5e-01	4.9e-02	1.5e-01
4	YFS	Blood	0.0397	0.0137	9.8e-09	0.038	0.027	0.037	0.029	0.039	1.7e-12	3.3e-09	4.6e-12	6.9e-10	1.2e-12
5	TCGA	Thyroid Carcinoma	0.0560	0.0310	1.2e-04	0.026	0.041	0.041	NA	0.037	1.2e-03	6.4e-05	6.8e-05	NA	1.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.4	1.0	0.1	-0.9	-0.4	0.2	-1.0
Bipolar Disorder or Schizophrenia	3.0	7.2	15.9	1.4	1.2	2.6	3.1	-4.0
Depressed Affect (Nagel 2018)	3.2	6.6	12.7	-0.3	0.8	3.6	3.6	-2.7
Depression (Nagel 2018)	8.0	12.0	22.3	0.5	2.7	4.7	4.2	-3.6
Intelligence (Savage-Jansen 2018)	4.9	14.9	27.7	-3.1	-0.9	-4.1	-4.5	5.3
Neuroticism (Nagel 2018)	7.3	17.2	31.9	0.1	2.8	5.6	5.5	-4.1
Schizophrenia (2018)	5.3	11.0	18.5	1.8	2.3	3.7	3.8	-4.3
Schizophrenia vs Biploar Disorder	5.7	7.5	17.0	2.4	2.8	4.1	2.0	-1.8
Worry (Nagel 2018)	3.0	6.3	11.7	-0.4	2.3	2.8	3.4	-2.6
Alzheimer’s Disease (in mother)	1.0	1.2	2.2	1.3	1.5	0.0	-0.8	1.1
Alzheimer’s Disease (in father)	1.3	1.4	3.2	0.8	0.7	0.7	1.8	-1.5
Alzheimer’s Disease (including proxy)	2.0	2.8	5.0	2.2	2.1	0.9	1.5	-1.3
Crohns Disease (2017)	0.1	0.2	0.6	-0.3	-0.8	-0.2	0.1	0.2
Irritable Bowel Disease (IBD)	0.4	1.0	2.8	-0.9	-1.7	-1.0	0.6	-0.4
Ulcerative Colitis (UC)	0.9	1.6	2.5	-1.2	-1.6	-0.9	1.4	-1.2
Major Depression (MDD)	6.3	7.6	14.6	1.3	-0.2	3.8	3.6	-2.9
Reaction Time	1.1	2.1	4.5	2.1	0.0	1.6	1.1	-1.4
Verbal and Numeric Reasoning (VNR)	5.0	12.0	18.4	-3.6	-1.9	-3.2	-3.8	4.3
Breast Cancer	1.9	4.6	7.5	-0.6	-1.8	-2.5	-2.7	2.3
Ovarian Cancer	1.9	2.5	7.0	1.6	-2.7	-1.2	-1.1	0.5
Prostate Cancer	2.5	3.5	5.6	-2.0	0.1	-1.7	-2.4	2.3
Age at First Birth	0.3	0.4	1.1	0.5	1.1	0.3	0.2	-0.6
Bipolar Disorder (2011)	1.1	1.1	3.6	0.4	-0.0	0.3	1.2	-1.9
Body Mass Index (BMI) (2010)	0.9	1.2	2.1	1.0	-0.4	1.5	1.1	-1.3
Coronary Artery Disease (CAD)	0.3	0.4	1.3	0.2	0.6	1.2	0.3	-0.1
Crohns Disease (2012)	0.3	0.5	1.0	-0.6	-0.5	-0.6	-0.7	1.0
Mean Putamen Volume	1.6	1.9	3.6	-0.5	-1.1	-1.7	-1.2	1.9
Fasting Glucose	0.7	0.9	2.1	-0.8	-1.4	-1.2	-0.6	-0.0
HbA1C	0.8	0.9	2.0	-1.4	0.5	-1.2	-0.9	0.5
HDL Cholesterol	0.2	0.4	1.1	-0.1	0.5	-0.2	0.8	-1.0
LDL Cholesterol	0.5	0.8	1.3	-0.8	-1.1	-0.4	-0.8	1.1
Lupus	0.1	0.1	0.2	0.5	-0.2	0.2	-0.0	0.4
Neuroticism (2016)	2.3	3.4	6.3	-1.6	0.3	2.4	2.5	-1.5
Primary Biliary Cirrhosis	1.8	2.5	4.1	0.4	1.9	1.7	2.0	-1.4
Rheumatoid Arthritis	1.2	1.7	2.9	1.3	1.2	-0.0	1.6	-1.7
Schizophrenia (2014)	6.2	13.8	23.1	1.7	2.4	4.3	4.3	-4.8
Triglycerides	0.8	1.4	3.0	1.7	0.8	1.5	0.5	-1.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	-0.3	-1.1	-1.0	-0.1	0.5
Ulcerative Colitis	1.4	2.1	4.6	-1.3	-1.5	-2.1	-0.9	1.0
Blood Eosinophil Count	2.2	17.3	22.8	4.8	4.1	4.6	3.3	-3.9
Blood Platelet Count	6.2	71.3	134.6	5.0	3.0	7.6	11.6	-11.4
Blood Red Count	1.3	12.3	26.5	1.9	1.3	2.9	4.6	-5.2
Blood White Count	0.2	1.7	4.3	2.1	-1.7	0.7	-0.0	-0.9
Heel T-Score	2.5	19.9	29.2	5.1	2.6	3.9	5.4	-4.8
BMI	0.5	2.9	7.6	-0.4	-0.1	2.8	1.9	-1.8
Height	1.1	22.1	39.1	-5.7	-3.9	-6.2	-3.5	3.4
Waist Hip Ratio (WHR)	1.3	5.8	15.7	-2.8	-4.0	-2.2	-0.7	0.3
Systolic Blood Pressure	4.5	22.5	32.6	-4.0	-4.3	-3.7	-5.6	5.7
Smoking Status	1.1	2.7	3.8	-1.9	-1.6	0.0	1.9	-1.9
Allergy or Eczema	0.1	0.4	0.9	-0.8	0.7	0.9	0.1	0.2
Cardiovascular Disease	0.5	1.6	4.2	-2.1	-0.1	1.2	1.3	-0.7
Hypothyroidism (self reported)	0.6	1.4	3.2	1.8	1.4	1.3	-0.3	-0.4
Respiratory disease	0.8	1.7	3.5	-0.3	1.2	1.5	1.9	-1.1
Type 2 Diabetes (T2D) (2018)	0.9	1.7	7.1	-1.1	-2.7	-0.6	0.2	-0.1
Lung FEV1/FVC ratio	5.5	27.7	56.1	-1.7	-1.9	-5.8	-7.5	6.5
Lung FVC	0.1	0.6	1.6	1.2	1.0	0.4	0.4	-0.0
Neuroticism	6.0	14.4	29.1	0.5	2.3	5.4	4.8	-3.8
Chronotype (morning person)	4.8	11.0	20.2	-1.0	-4.4	-4.5	-3.0	2.4
Hair Pigment	0.0	0.5	0.8	-0.3	-0.9	-0.3	-0.7	0.9
Tanning	0.1	1.3	2.6	0.4	-0.4	-1.6	-1.6	0.9
Hand grip strength (left)	2.2	5.8	14.5	-2.4	-1.6	-3.8	-2.1	1.2
Number of treatments/medications taken	0.6	1.1	3.0	-1.7	-0.4	0.7	1.2	-0.6
Average weekly spirits intake	0.4	0.5	1.9	1.4	0.4	-0.0	0.3	-0.4
Sensitivity / hurt feelings	3.3	5.6	10.8	0.9	0.8	3.1	3.3	-2.4
Frequency of depressed mood in last 2 weeks	9.0	12.6	20.2	0.6	2.9	4.4	4.5	-3.8
Hearing difficulty/problems: Yes	1.7	2.6	5.2	-0.0	-0.4	1.6	2.3	-2.3
Relative age of first facial hair	0.3	0.6	1.8	-1.3	-0.5	-0.2	-0.7	0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.5	0.6	0.6	0.7	1.6	-1.0
Ever used hormone-replacement therapy (HRT)	1.6	2.0	4.8	1.0	1.7	2.2	1.0	-0.5
Ever had hysterectomy (womb removed)	1.6	1.8	3.5	-0.5	1.9	-0.3	-1.6	1.6
Systolic blood pressure, automated reading	2.8	8.1	9.9	-2.8	-3.0	-2.0	-3.1	3.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.3	0.5	-0.4	-1.1	-0.8	0.9
Angina	2.7	3.5	9.0	-3.0	-2.3	-1.2	-1.2	0.8
Medication for hormone replacement therapy	0.2	0.2	0.9	0.2	0.2	0.9	0.1	0.3
Vitamin and mineral supplements	1.4	1.9	5.3	-0.5	-2.3	-1.4	-1.1	0.8
Supplements: Zinc	0.4	0.4	0.8	-0.9	0.1	-0.9	-0.1	0.7
Medication: Co-codamol	0.7	0.8	1.3	0.2	0.6	1.1	0.9	-1.1
Medication: Metformin	1.0	1.4	6.0	-0.8	-2.4	-0.1	0.5	-0.5
Diabetes (father)	0.4	0.5	1.1	0.7	-0.7	0.6	0.4	-1.1
Diabetes (mother)	1.4	1.8	4.3	-1.6	-2.1	-1.3	0.4	-0.3
Severe depression (siblings)	0.3	0.3	1.3	-1.1	0.1	-0.1	-0.4	0.0
Pack years adult smoking proportion	3.8	5.8	10.3	2.2	0.0	2.2	3.2	-3.0
Impedance of leg (right)	0.1	0.3	1.0	0.1	-0.3	-0.3	0.5	-1.0
Leg fat-free mass (left)	0.3	1.5	4.1	-2.0	-1.3	-0.6	-0.7	0.9
Trunk fat percentage	1.8	7.4	13.7	-0.2	0.5	3.7	3.5	-3.2
Hand grip strength (right)	2.1	5.8	10.2	-2.6	-1.4	-3.2	-2.5	1.9
Townsend deprivation index at recruitment	4.3	6.0	12.2	0.4	1.0	2.8	3.5	-3.0
Current tobacco smoking	3.1	5.1	13.6	-0.5	-0.3	1.0	3.7	-3.3
Average weekly fortified wine intake	0.3	0.4	0.7	0.8	0.2	0.4	0.5	-0.8
Maternal smoking around birth	0.5	0.7	1.3	-0.4	-0.9	0.7	1.1	-0.8
Fed-up feelings	6.5	11.8	21.7	1.3	1.8	4.7	4.3	-3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	6.7	8.9	15.4	0.9	2.6	3.9	3.6	-3.0
Relative age voice broke	0.3	0.5	1.1	-0.0	0.8	0.1	-0.9	1.1
Taking other prescription medications	0.6	1.0	1.8	-0.5	1.0	1.3	1.3	-0.3
Age when periods started (menarche)	0.5	1.2	3.2	-0.9	0.4	-1.8	-1.0	1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	-1.2	-0.5	0.4	-0.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	4.3	0.6	0.1	-1.1	2.1	-1.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.3	1.1	0.6	-0.7	0.1	-0.8
Qualifications: CSEs or equivalent	2.3	3.0	5.0	1.0	0.6	1.9	2.2	-2.2
Serious illness, injury or assault to yourself	0.1	0.2	0.5	0.3	-0.3	-0.7	-0.3	0.3
High blood pressure	0.8	2.2	6.0	-2.5	-0.7	1.2	1.4	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	-1.0	0.1	-0.2	-0.9	0.8
Multivitamins +/- minerals	0.9	1.1	2.8	0.7	1.7	0.7	1.0	-0.8
Stomach or abdominal pain in last month	0.2	0.3	0.8	0.0	-0.9	0.3	0.5	-0.2
Supplements: Glucosamine	0.9	1.2	3.3	-0.4	-0.5	-1.8	-0.9	1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	2.0	-1.0	-1.4	-0.1	0.5	-0.6
Medication: Atenolol	0.7	0.8	2.3	-1.5	-1.2	0.2	0.6	-0.2
Medication: Levothyroxine sodium	0.3	0.5	1.2	0.5	1.1	0.9	0.2	-0.2
Sitting height	2.0	14.0	21.3	-3.1	-2.5	-4.6	-4.1	4.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-0.7	-0.7	-1.1	0.5	-0.6
High blood pressure (mother)	1.5	2.1	4.1	-2.0	-1.3	-1.6	-1.0	1.1
Body mass index (BMI)	0.5	2.3	6.7	-0.5	0.2	2.6	1.6	-1.3
Impedance of leg (left)	0.1	0.6	1.4	0.2	-0.8	-0.5	0.9	-1.2
Leg predicted mass (left)	0.3	1.5	4.2	-2.0	-1.1	-0.5	-0.8	1.0
Trunk fat mass	0.9	3.9	6.8	-1.1	-0.3	2.6	2.5	-2.2
Waist circumference	0.7	2.6	6.4	-2.5	-2.4	0.2	0.6	-0.6
Number of incorrect matches in round	0.3	0.5	0.9	0.5	-0.0	0.9	0.8	-1.0
Past tobacco smoking	0.6	1.1	2.6	1.5	1.6	0.1	-0.4	0.6
Alcohol usually taken with meals	7.8	12.7	26.4	0.1	-1.6	-4.3	-5.1	3.9
Nervous feelings	0.5	1.0	2.5	-1.6	0.8	1.2	0.5	0.4
Frequency of tenseness / restlessness in last 2 weeks	4.3	6.7	11.3	0.4	2.6	3.4	3.0	-2.5
Hearing difficulty/problems with background noise	0.7	1.1	2.6	0.6	0.2	1.0	1.1	-1.6
Hair/balding pattern: Pattern 2	4.1	5.2	16.4	-2.6	-0.5	-4.0	-1.2	1.0
Had menopause	0.4	0.6	1.8	0.3	1.3	0.9	-0.2	0.2
Had other major operations	1.9	2.3	9.4	-3.1	0.1	-1.1	-0.4	0.8
Forced vital capacity (FVC)	0.9	3.3	4.6	-2.0	-1.8	-2.1	-1.6	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.0	1.7	-0.5	-0.7	1.5	-1.4
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.7	0.4	0.9	1.9	1.7	-1.7
Qualifications: None of the above	4.6	9.9	18.5	1.7	2.0	4.3	3.5	-3.4
Financial difficulties in last 2 years	2.2	3.0	5.8	-0.0	1.2	2.4	2.3	-1.5
Mouth/teeth dental problems	0.7	1.0	1.7	-1.0	-0.8	-1.0	-1.3	0.8
Heart attack	1.2	1.5	4.0	-1.9	-2.0	-0.2	0.2	0.2
Allergy	0.2	0.5	0.9	0.6	-0.8	-0.9	-0.7	0.4
Pain all over the body in last month	2.4	2.6	4.9	1.7	-0.4	2.2	1.6	-1.6
Diabetes (self-reported)	1.6	2.4	5.5	-2.0	-2.3	-1.3	-0.5	0.8
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.2	-0.4	-1.2	0.1	-1.8	1.8
Medication: Ramipril	0.6	0.8	2.7	-1.6	-1.0	-0.6	-0.2	-0.1
Medication: Simvastatin	0.3	0.4	1.2	-0.5	-1.1	-0.6	0.2	-0.4
Fluid intelligence score	4.2	8.7	14.2	-3.2	-1.5	-2.6	-3.2	3.8
Illnesses of siblings	0.9	1.2	2.3	-1.1	0.7	-1.5	-1.1	0.9
Neuroticism score	6.0	12.4	24.0	0.0	1.2	4.7	4.9	-3.8
Weight	0.3	1.6	5.5	-2.4	-1.4	0.4	0.4	-0.1
Impedance of arm (right)	1.1	5.0	9.7	0.9	1.6	1.6	3.1	-3.1
Arm fat percentage (right)	1.8	7.3	13.6	-0.1	1.1	3.7	3.4	-3.1
Trunk fat-free mass	1.3	7.4	10.0	-3.2	-2.6	-2.7	-2.6	2.5
Hip circumference	0.3	1.4	6.1	-2.5	-0.9	0.2	0.2	-0.0
Time employed in main current job	0.5	0.6	1.1	-0.8	1.0	1.0	0.2	-0.0
Alcohol intake versus 10 years previously	0.5	0.8	2.0	-1.4	-0.8	0.9	0.6	0.3
Father’s age at death	0.4	0.5	1.0	0.6	0.2	-1.0	-0.9	0.6
Worrier / anxious feelings	7.3	13.9	26.7	1.3	1.5	4.2	5.2	-4.6
Frequency of tiredness / lethargy in last 2 weeks	7.7	12.4	23.8	0.2	2.4	4.6	4.9	-3.3
Falls in the last year	0.8	1.1	2.2	0.0	1.3	0.9	1.5	-1.0
Hair/balding pattern: Pattern 3	1.1	1.6	2.8	-1.4	-0.9	-0.6	-1.5	1.7
Number of live births	0.1	0.1	0.5	0.2	-0.2	0.7	0.2	-0.3
Forced expiratory volume in 1-second (FEV1)	3.1	10.5	16.0	-2.2	-1.9	-4.0	-3.8	3.6
Pulse rate	0.3	0.5	2.3	-1.5	0.2	-0.6	-0.1	0.3
Happiness	2.7	3.3	6.5	1.6	2.5	2.3	1.2	-0.8
Noisy workplace	1.1	1.4	3.9	2.0	-1.4	-0.9	-0.6	0.1
Qualifications: A levels/AS levels or equivalent	3.0	6.6	12.7	-1.4	-1.8	-3.6	-2.9	2.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.0	-0.9	-0.5	-1.4	-1.4	1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	0.3	0.2	1.1	0.9	-0.3
Asthma	0.4	0.7	2.4	-0.5	0.4	1.6	0.9	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.1	0.3	-0.4	0.6	-0.1
Medication: Cholesterol lowering	2.1	3.2	10.0	-2.0	-3.2	-1.2	-0.7	0.4
Depression (self-reported)	3.9	4.7	7.7	0.2	2.5	2.8	2.6	-1.8
Medication: Lansoprazole	1.3	1.5	3.7	-1.9	0.5	1.1	1.5	-0.4
Prospective memory result	7.8	9.5	16.4	2.1	1.3	3.3	4.0	-3.7
Lung cancer (father)	1.1	1.3	4.5	0.4	-0.2	0.2	2.1	-1.4
Illnesses of mother	0.9	1.1	4.0	2.0	-0.4	0.4	0.4	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	3.3	10.7	15.9	-1.8	-2.5	-4.0	-3.7	3.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	-0.3	-0.5	-0.8	0.6	-1.0
Impedance of arm (left)	0.9	3.9	8.0	0.8	1.5	1.5	2.8	-2.6
Arm fat mass (right)	0.9	3.7	6.7	-1.1	0.2	2.6	2.5	-2.1
Trunk predicted mass	1.3	7.4	10.2	-3.2	-2.6	-2.7	-2.6	2.5
Standing height	1.3	13.0	20.6	-4.0	-3.8	-4.5	-2.7	2.5
Length of working week for main job	0.8	0.9	3.0	-1.0	-1.7	-0.7	0.1	0.1
Exposure to tobacco smoke at home	1.1	1.3	4.0	0.7	0.6	2.0	0.9	-0.9
Breastfed as a baby	0.9	1.1	3.1	-1.8	-0.4	-0.5	-0.7	1.2
Tense / ‘highly strung’	2.0	3.3	5.1	-0.2	2.2	2.3	2.1	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	8.8	0.9	0.1	1.9	3.0	-2.6
Hair/balding pattern: Pattern 4	0.5	1.2	3.7	-0.0	1.9	1.4	0.6	0.2
Birth weight of first child	0.4	0.8	3.1	-0.2	0.7	-1.8	-0.4	0.2
Peak expiratory flow (PEF)	3.9	9.0	14.3	-1.1	-2.2	-3.8	-3.8	3.3
Pulse wave reflection index	0.2	0.2	0.6	0.6	0.2	-0.1	0.5	-0.7
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	-0.1	0.5	-0.4	0.4	-0.4
Loud music exposure frequency	1.1	1.3	2.5	0.7	-0.2	1.0	1.6	-1.5
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	5.2	-0.8	-1.2	-2.3	-1.6	1.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	0.8	-0.3	-1.1	-0.5	0.5
Blood clot in the leg (DVT)	2.9	3.7	4.7	1.8	1.7	1.9	2.0	-2.2
Medication: Paracetamol	2.3	3.9	8.5	0.1	0.6	1.6	2.9	-2.8
Headache pain in last month	5.1	8.8	19.1	0.8	1.6	2.2	4.4	-4.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.7	1.9	2.2	0.4	-0.2	0.3
Glaucoma (self-reported)	3.6	4.3	6.5	-2.2	-2.6	-2.4	-1.0	1.8
Gout (self-reported)	1.5	2.0	7.3	-2.7	-1.5	-0.5	0.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.1	1.0	1.1	0.5	-0.9	0.5
Medication: Amlodipine	0.1	0.2	1.0	0.0	-1.0	-0.2	-0.1	0.0
Medication: Ventolin 100micrograms inhaler	1.2	1.6	4.7	0.4	-0.4	0.9	2.2	-1.4
Birth weight	0.8	1.8	4.0	-2.0	-0.1	-1.9	-1.0	0.5
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.7	-0.5	0.7	1.6	1.6	-1.4
High blood pressure (siblings)	0.5	0.8	3.5	-0.1	-1.9	0.2	0.4	-0.5
Forced vital capacity (FVC), Best measure	0.8	2.8	4.0	-1.6	-2.0	-2.0	-1.3	1.4
Body fat percentage	1.8	7.2	14.1	-0.2	0.4	3.8	3.4	-3.2
Leg fat percentage (right)	1.3	4.6	10.2	-0.3	-0.0	3.2	2.5	-2.5
Arm fat-free mass (right)	0.9	4.9	6.9	-2.6	-2.3	-1.8	-2.2	2.1
Exposure to tobacco smoke outside home	0.4	0.6	1.5	-0.3	0.1	-0.4	-1.2	1.1
Comparative body size at age 10	2.5	6.8	10.8	1.0	2.5	2.5	3.3	-3.2
Number of full brothers	2.0	2.5	4.7	-0.4	-1.9	-2.2	-1.5	1.2
Worry too long after embarrassment	8.1	13.6	25.0	0.1	2.0	5.0	4.8	-4.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.0	-0.2	1.0	1.2	1.7	-1.2
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	-0.3	-0.0	0.8	1.3	-0.3
Number of children fathered	2.1	2.3	4.6	0.5	-1.4	-0.8	-2.1	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.8	0.5	0.3	1.4	0.3	-0.9
Age at first live birth	1.3	2.3	3.8	-1.9	0.2	-1.7	-1.5	1.5
Pulse wave peak to peak time	0.3	0.4	1.2	-0.0	0.1	0.5	-0.7	1.1
Health satisfaction	0.4	0.5	1.4	-0.1	1.2	0.6	0.7	-0.4
Shortness of breath walking on level ground	1.0	1.2	2.6	0.5	0.3	1.6	1.2	-1.2
Qualifications: College or University degree	3.7	11.7	20.2	-0.5	-2.4	-4.5	-4.3	3.7
Eye problems/disorders: None of the above	0.5	0.6	1.6	0.2	1.2	0.4	0.6	-1.0
Mouth/teeth dental problems: Loose teeth	4.4	5.2	8.7	1.2	0.7	2.9	2.7	-2.9
Emphysema/chronic bronchitis	0.3	0.4	1.0	-1.0	0.6	-0.6	-0.1	0.4
Medication for pain relief, constipation, heartburn	1.3	2.2	5.0	0.7	0.3	-1.0	-2.2	2.1
Neck or shoulder pain in last month	2.0	2.8	4.9	1.5	1.9	2.2	1.4	-1.1
Medication: Blood pressure	0.8	1.4	1.9	-1.1	-1.4	0.7	1.3	-1.2
Angina (self-reported)	3.0	3.9	10.8	-3.3	-2.2	-1.4	-1.2	0.8
Migraine (self-reported)	3.2	3.9	8.9	1.1	1.2	0.4	3.0	-2.8
Medication: Ibuprofen	0.1	0.2	0.4	0.1	0.6	-0.4	0.3	0.2
Medication: Allopurinol	0.2	0.3	0.9	-1.0	-0.2	0.8	0.1	-0.0
Medication: Omeprazole	0.3	0.3	0.8	-0.8	-0.9	0.3	0.3	0.2
Medication: Seretide 50 evohaler	4.4	5.1	10.5	0.2	1.1	2.4	3.2	-2.8
Mean time to correctly identify matches	1.5	2.9	5.9	2.2	0.2	2.4	1.3	-1.5
Heart disease (mother)	1.4	1.7	3.6	-1.9	-0.6	-1.0	-1.4	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	4.0	-0.1	2.0	0.2	-0.7	0.2
Whole body fat mass	0.7	3.1	5.5	-1.2	-0.6	2.4	2.2	-1.9
Leg fat mass (right)	0.6	2.3	4.8	-1.1	-0.5	2.2	1.7	-1.5
Arm predicted mass (right)	0.8	4.1	6.4	-2.5	-2.3	-1.6	-1.8	1.8
Pulse rate, automated reading	3.5	11.3	20.5	1.2	2.2	3.7	4.5	-4.0
Alcohol intake frequency.	4.6	10.7	20.7	0.5	2.3	4.5	4.1	-3.3
Comparative height size at age 10	0.2	1.3	2.8	-0.9	-1.7	-0.9	-1.1	1.0
Number of full sisters	1.4	1.7	3.3	0.5	-0.5	-1.5	-1.8	1.6
Suffer from ‘nerves’	1.7	2.6	5.8	-0.3	2.4	1.6	1.7	-1.3
Overall health rating	4.5	9.6	20.0	0.4	2.6	4.5	3.6	-2.8
Chest pain or discomfort	1.4	2.1	7.0	-2.6	-0.7	-1.2	-0.4	1.1
Had major operations	0.5	0.6	1.2	-0.2	-1.1	-0.7	0.4	-1.1
Age at last live birth	0.1	0.2	0.5	0.1	0.3	0.7	-0.2	0.4
Family relationship satisfaction	0.1	0.2	0.6	0.8	0.0	0.3	-0.4	0.2
Leg pain on walking	1.5	1.9	3.7	-1.8	-0.0	-1.9	-0.8	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	0.9	-0.7	0.2	0.9	-1.2
Commuting to job workplace: Car/motor vehicle	2.4	2.8	4.6	1.6	2.0	2.1	1.4	-1.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.3	0.1	0.3	-0.0	-0.4
Medication: Aspirin	0.9	1.2	2.6	-1.6	0.0	0.5	1.3	-1.2
Supplements: Vitamin C	0.6	0.7	2.4	-0.7	1.6	-0.1	0.6	-0.3
Knee pain experienced in last month	0.2	0.3	1.0	1.0	0.6	-0.1	0.1	-0.3
Hypertension (Self-reported)	0.7	1.9	5.9	-2.4	-0.3	1.2	1.2	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	7.3	-2.7	-0.7	-0.8	-0.3	1.3
Illnesses of father: Heart disease	1.0	1.4	6.5	-2.6	0.1	0.2	-0.3	0.6
Illnesses of siblings: Diabetes	0.2	0.3	0.5	0.7	0.0	0.5	0.7	-0.4
Smoking status: Previous	0.4	0.6	1.3	-0.6	-1.2	0.1	-1.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	6.6	-0.8	-1.2	-2.6	-1.8	0.9
Whole body fat-free mass	0.8	4.4	6.9	-2.6	-2.2	-1.8	-1.9	1.9
Leg fat-free mass (right)	0.3	1.5	3.8	-1.9	-1.4	-0.8	-0.6	0.9
Arm fat percentage (left)	1.7	6.7	13.5	-0.2	1.2	3.7	3.2	-2.8
Average weekly red wine intake	11.1	16.4	33.4	-1.2	-2.5	-5.8	-5.0	4.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	0.8	0.7	0.5	0.2	-0.7
Mood swings	1.5	2.8	7.3	-0.2	-0.1	1.8	2.7	-1.8
Loneliness, isolation	3.8	5.3	11.3	-0.4	1.8	3.4	2.9	-1.8
Long-standing illness, disability or infirmity	0.7	1.1	1.9	-1.4	-1.2	0.3	1.2	-0.8
Ever had bowel cancer screening	0.8	0.9	2.3	0.2	-0.1	-0.4	-1.5	1.5
Diabetes diagnosed by doctor	0.8	1.3	5.5	-0.4	-2.3	0.3	0.6	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.9	0.1	-1.4	-0.2	0.0	-0.4
Friendships satisfaction	0.5	0.6	2.2	1.5	-0.6	0.2	0.5	0.2
Qualifications: nursing, teaching	6.4	9.9	15.9	-2.1	-1.9	-4.0	-3.5	3.6
Commuting to job workplace: Walk	1.8	2.0	7.4	-0.5	0.0	-0.2	-2.7	1.5
Eye problems/disorders: Cataract	0.1	0.2	0.3	0.0	0.3	0.5	0.4	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.9	-0.4	-0.5	0.0	0.2
Medication for cholesterol	0.5	0.7	2.6	1.6	0.4	-0.6	-0.6	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.4	0.1	1.9	1.1	0.2	-0.2
Back pain experienced in last month	0.4	0.6	2.2	-0.2	1.5	0.9	0.1	-0.0
Mineral and other dietary supplements	2.3	3.1	5.3	1.3	0.4	2.2	1.8	-2.3
Breast cancer (self-reported)	0.8	1.0	1.8	0.5	1.3	1.1	1.1	-0.6
Asthma (self-reported)	0.5	0.9	2.5	-0.7	0.3	1.6	1.2	-0.3
Osteoporosis (self-reported)	0.3	0.4	0.8	-0.1	0.7	0.9	-0.1	0.7
Osteoarthritis (self-reported)	0.9	1.2	2.6	-0.4	0.8	0.4	1.5	-1.6
Medication: Aspirin	0.7	0.9	3.6	-1.9	0.1	-0.0	0.8	-0.7
Medication: Gliclazide	1.1	1.3	3.6	-1.3	-1.9	0.6	0.2	-0.7
Illnesses of father: None of the above (group 1)	0.4	0.4	1.7	1.3	-0.4	-0.6	0.1	0.0
Smoking status: Current	3.2	5.0	13.2	-0.6	-0.3	0.9	3.6	-3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	6.0	9.0	-0.2	-2.0	-2.9	-2.9	3.0
Whole body water mass	0.7	3.8	6.3	-2.5	-2.0	-1.6	-1.7	1.7
Leg predicted mass (right)	0.3	1.5	3.8	-1.9	-1.4	-0.9	-0.6	0.9
Arm fat mass (left)	0.8	3.2	6.7	-1.1	0.2	2.6	2.2	-1.8
Number of self-reported non-cancer illnesses	0.6	1.1	3.6	-1.9	0.0	1.0	0.7	-0.3
Average weekly champagne plus white wine intake	0.2	0.3	0.9	0.6	-0.9	0.0	0.6	-0.2
Miserableness	0.9	1.6	3.9	-0.5	0.4	1.4	2.0	-1.4
Guilty feelings	2.9	4.3	13.6	-0.8	0.8	3.7	2.3	-1.2
Wears glasses or contact lenses	1.4	1.6	3.0	-0.4	-0.8	-1.3	-1.7	1.6
Ever taken oral contraceptive pill	6.4	7.2	10.2	-2.8	-3.1	-3.2	-2.0	2.0
Hearing aid user	3.0	3.4	4.8	-1.6	-1.6	-1.7	-2.1	2.2
Mother’s age at death	0.2	0.3	0.8	-0.9	-0.1	-0.8	0.1	0.2
Financial situation satisfaction	0.7	0.9	1.6	1.3	-0.4	0.8	1.2	-0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.6	0.0	1.2	1.3	0.6	-0.8
Commuting to job workplace: Public transport	1.9	2.3	4.0	-2.0	-1.0	-1.7	-1.4	1.4
Eye problems/disorders: Glaucoma	4.6	5.5	8.9	-2.0	-3.0	-2.8	-1.5	2.1
Medication: Blood pressure	0.6	1.1	4.9	-2.2	-0.2	0.4	0.5	-0.4
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.0	0.5	-0.0	1.4	1.4	-1.4
Supplements: Fish oil (including cod liver oil)	2.7	3.5	7.2	-0.6	-0.5	-1.7	-2.6	2.7
High cholesterol (Self-reported)	0.7	1.2	2.5	-0.2	-0.9	0.8	1.4	-1.6
Medication: Bendroflumethiazide	0.6	0.9	3.0	-1.7	0.8	0.3	-0.6	0.8
Medication: Paracetamol	3.4	5.3	11.8	0.3	0.7	1.9	3.4	-3.2
Medication: Lisinopril	0.3	0.4	1.7	-1.3	0.3	-0.2	-0.3	0.2
Medication: Atorvastatin	3.1	3.8	13.0	-1.2	-3.6	-0.5	-1.6	1.3
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.7	1.0	-0.5	-0.5	0.3
Alcohol drinker status: Never	1.6	1.9	3.5	0.0	1.9	1.6	1.6	-1.0
Ever smoked	0.6	1.0	1.7	-1.2	-0.7	-0.1	1.2	-1.3
Basal metabolic rate	0.5	3.0	6.9	-2.6	-1.9	-1.2	-1.2	1.3
Leg fat percentage (left)	1.3	4.6	9.5	-0.2	-0.2	3.1	2.7	-2.4
Arm fat-free mass (left)	0.7	3.3	6.6	-2.6	-2.0	-1.3	-1.5	1.4
Number of operations (self-reported)	1.5	2.3	5.2	-0.6	-1.7	-2.3	-1.5	0.8
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.5	0.5	-0.2	-0.4	-0.1
Irritability	2.1	3.6	8.0	0.3	0.6	2.3	2.8	-2.1
Risk taking	1.0	1.4	4.3	0.4	-2.1	-1.6	-0.4	0.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.9	0.0	-0.4	-1.2	-1.4	1.3
Fractured/broken bones in last 5 years	2.0	2.6	5.4	-1.6	-0.8	-0.7	-2.1	2.3
Age started oral contraceptive pill	0.8	1.0	2.6	-0.9	-1.0	-1.6	-0.4	0.6
Diastolic blood pressure, automated reading	0.4	1.3	3.1	-1.7	-1.8	0.1	-0.3	0.5
Ever depressed for a whole week	0.9	1.1	2.1	1.1	-0.3	1.4	1.1	-0.9
Unable to work because of sickness or disability	5.6	7.3	11.1	1.2	2.6	3.3	2.9	-3.0
Commuting to job workplace: Cycle	2.4	2.9	6.8	0.4	-0.6	-1.7	-2.6	2.1
Myopia	0.3	0.4	1.5	0.5	0.3	0.5	1.2	-0.4
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.8	2.6	1.3	-0.9	-1.1	0.6
Cholesterol lowering medication	0.8	1.2	2.1	-0.1	0.1	1.3	1.4	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	-1.2	-0.5	0.8	0.7	0.2
Pain experienced in last month	4.9	8.1	12.5	-1.9	-2.9	-3.5	-2.9	2.7
Supplements: Calcium	0.2	0.2	0.4	0.3	0.5	0.3	-0.2	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.0	0.7	-0.5	-0.4	-0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.7	-1.6	-1.6	0.1	0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	3.6	1.6	1.3	1.5	1.7	-1.9
Heart disease (siblings)	0.2	0.3	0.8	0.2	-0.9	0.6	0.4	-0.1
Alcohol drinker status: Previous	5.2	5.9	13.2	0.8	0.4	2.1	3.6	-3.3
Pack years of smoking	3.4	5.0	9.0	2.0	-0.1	2.0	3.0	-2.9
Impedance of whole body	0.3	1.5	3.4	0.7	0.4	0.6	1.8	-1.8
Leg fat mass (left)	0.6	2.3	4.4	-1.1	-0.7	2.1	1.8	-1.6
Arm predicted mass (left)	0.5	2.7	5.8	-2.4	-1.9	-1.1	-1.3	1.1