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chr11:112,135,760-113,969,669

Best TWAS P=3.51e-17 · Best GWAS P=6.17e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Coronary	TTC12	0.56	0.15	enet	28	0.19	4.5e-07	-6.6	5.3	1.2e-07	-0.02	0.86	0.07	FALSE
2	GTEx	Brain Caudate basal ganglia	TTC12	0.57	0.20	lasso	9	0.38	4.4e-12	3.5	5.5	4.2e-08	-0.08	0.97	0.00	FALSE
3	GTEx	Brain Caudate basal ganglia	RP11-159N11.4	0.32	0.07	lasso	7	0.14	9.7e-05	3.3	5.9	4.7e-09	-0.11	0.47	0.04	FALSE
4	GTEx	Brain Cortex	TTC12	0.48	0.39	lasso	5	0.43	3.2e-13	5.3	5.5	2.9e-08	-0.10	0.96	0.01	FALSE
5	GTEx	Brain Hypothalamus	RP11-159N11.4	0.44	0.06	lasso	19	0.03	7.5e-02	5.3	6.7	1.8e-11	-0.08	0.14	0.06	FALSE
6	GTEx	Breast Mammary Tissue	TTC12	0.46	0.30	lasso	7	0.40	8.1e-22	5.3	6.3	2.9e-10	-0.11	0.99	0.01	FALSE
7	GTEx	Breast Mammary Tissue (Female)	TTC12	0.46	0.22	lasso	10	0.34	6.2e-11	-6.4	5.8	6.6e-09	-0.06	0.91	0.06	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	TTC12	0.67	0.39	enet	34	0.54	4.6e-23	-5.9	6.3	3.9e-10	-0.10	0.99	0.01	FALSE
9	GTEx	Esophagus Muscularis	TTC12	0.67	0.46	enet	28	0.62	7.2e-48	-6.0	5.3	9.9e-08	-0.09	0.98	0.02	TRUE
10	GTEx	Heart Left Ventricle	TTC12	0.39	0.24	enet	36	0.38	2.5e-21	7.5	7.2	7.3e-13	-0.16	0.88	0.12	TRUE
11	GTEx	Muscle Skeletal	TTC12	0.44	0.34	lasso	10	0.40	2.4e-41	-6.4	5.6	1.9e-08	-0.05	1.00	0.00	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	TTC12	0.49	0.29	lasso	10	0.51	6.5e-32	5.3	5.9	4.1e-09	-0.12	0.99	0.01	FALSE
13	GTEx	Spleen	TTC12	0.55	0.46	lasso	5	0.46	2.1e-13	3.5	5.2	2.3e-07	-0.08	0.98	0.00	FALSE
14	GTEx	Spleen	RP11-159N11.4	0.30	0.06	lasso	6	0.06	1.4e-02	7.3	6.8	1.3e-11	-0.14	0.14	0.06	FALSE
15	GTEx	Testis	TTC12	0.42	0.16	enet	33	0.38	7.7e-18	7.3	7.6	4.2e-14	-0.41	0.75	0.24	FALSE
16	GTEx	Uterus	NCAM1	0.41	-0.01	lasso	11	-0.01	5.9e-01	5.3	7.6	4.1e-14	-0.22	0.08	0.08	TRUE
17	METSIM	Adipose	ANKK1	0.16	0.11	enet	13	0.16	9.8e-23	-4.3	-7.4	1.5e-13	0.28	1.00	0.00	FALSE
18	YFS	Blood	ANKK1	0.04	0.03	lasso	3	0.03	2.9e-09	-4.8	-5.9	4.2e-09	0.24	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	TTC12	0.19	0.12	blup	48	0.15	1.1e-28	7.5	5.7	1.1e-08	-0.10	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ANKK1	0.04	0.02	blup	66	0.03	5.0e-04	7.3	8.2	2.6e-16	-0.32	0.23	0.16	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANKK1	0.04	0.03	blup	67	0.04	6.3e-05	6.9	-8.0	1.2e-15	0.39	0.56	0.16	TRUE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TTC12	0.49	0.30	enet	22	0.40	3.2e-48	7.6	5.4	7.3e-08	-0.04	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DRD2	0.13	0.05	blup	97	0.07	5.7e-05	4.6	6.0	2.1e-09	-0.61	0.15	0.57	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTC12	0.37	0.22	enet	5	0.22	1.1e-12	5.8	5.9	2.8e-09	-0.13	0.04	0.96	TRUE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTC12	0.33	0.28	blup	48	0.30	1.4e-34	7.6	6.1	8.9e-10	-0.15	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ANKK1	0.08	0.02	blup	66	0.04	5.6e-03	6.4	-6.9	6.4e-12	0.16	0.18	0.06	TRUE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	DRD2	0.06	0.07	lasso	2	0.07	6.6e-09	-8.3	8.4	3.5e-17	-1.00	0.00	1.00	TRUE
28	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TTC12	0.25	0.12	blup	48	0.12	2.4e-08	5.8	5.7	1.1e-08	-0.15	0.09	0.91	FALSE
29	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TTC12	0.36	0.30	lasso	3	0.29	6.0e-12	7.6	7.5	4.4e-14	-0.22	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTC12	0.21	0.20	lasso	4	0.22	1.2e-22	7.6	7.0	2.8e-12	-0.19	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Stomach Adenocarcinoma	TTC12	0.25	0.10	enet	10	0.17	3.6e-12	5.8	5.4	5.2e-08	-0.10	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TTC12	0.07	0.06	blup	48	0.04	1.6e-02	5.8	7.8	8.2e-15	-0.25	0.01	0.75	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	ANKK1	0.09	0.06	blup	67	0.07	9.9e-08	7.3	-5.4	6.5e-08	0.29	0.75	0.21	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	TTC12	0.73	0.41	enet	24	0.51	3.9e-57	5.8	5.8	7.5e-09	-0.04	0.58	0.42	FALSE