Hub : Genes

NCAM1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.3029 0.1055 5.0e-03 -0.004 NA -0.006 NA -0.007 4.8e-01 NA 6.1e-01 NA 7.1e-01
2 GTEx Artery Aorta 0.3210 0.0590 4.0e-09 0.236 NA 0.232 NA 0.222 3.3e-13 NA 5.6e-13 NA 1.9e-12
3 GTEx Esophagus Muscularis 0.2020 0.0610 7.5e-04 -0.003 NA 0.005 NA -0.004 6.1e-01 NA 1.6e-01 NA 6.6e-01
4 GTEx Pancreas 0.1510 0.0630 9.8e-03 -0.007 NA -0.003 NA -0.004 9.1e-01 NA 4.5e-01 NA 5.5e-01
5 GTEx Skin Not Sun Exposed Suprapubic 0.1570 0.0560 2.0e-03 0.095 NA 0.017 NA 0.048 6.8e-06 NA 3.8e-02 NA 1.2e-03
6 GTEx Skin Sun Exposed Lower leg 0.1100 0.0350 4.8e-04 0.036 NA 0.014 NA 0.011 5.3e-04 NA 2.4e-02 NA 3.7e-02
7 GTEx Uterus 0.4080 0.1380 7.7e-03 -0.010 NA -0.011 NA -0.011 5.9e-01 NA 6.0e-01 NA 5.9e-01
8 METSIM Adipose 0.0719 0.0257 3.7e-04 0.051 0.027 0.057 0.053 0.056 3.3e-08 6.2e-05 6.8e-09 1.8e-08 9.4e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.3 0.4 2.4 0.6 -0.5 0.3 -1.5 0.0 0.2 0.6 -0.3
Bipolar Disorder or Schizophrenia 0.3 0.7 3.5 0.1 -0.6 -0.1 -0.3 -0.7 -0.2 1.9 1.0
Depressed Affect (Nagel 2018) 4.8 10.0 42.8 3.6 1.1 2.8 -1.6 2.8 1.5 6.5 -1.6
Depression (Nagel 2018) 2.9 4.3 23.6 2.2 0.3 2.0 -0.0 1.2 -0.6 4.9 -0.7
Intelligence (Savage-Jansen 2018) 2.9 9.0 21.9 -2.8 2.3 -0.6 -2.7 3.1 4.7 -4.3 0.9
Neuroticism (Nagel 2018) 4.8 11.4 57.1 3.4 0.5 3.4 -1.1 2.1 0.6 7.6 -2.2
Schizophrenia (2018) 0.5 1.0 3.7 -0.5 -0.4 -0.5 0.8 -1.0 -0.5 1.9 1.5
Schizophrenia vs Biploar Disorder 0.2 0.3 0.9 0.1 -0.2 0.3 0.9 -0.6 0.2 0.3 -0.9
Worry (Nagel 2018) 1.8 3.9 22.5 1.4 -0.7 1.4 1.0 0.2 -0.9 4.7 -1.5
Alzheimer’s Disease (in mother) 0.4 0.4 0.8 -0.4 0.9 -0.8 -0.7 0.9 0.1 -0.7 0.3
Alzheimer’s Disease (in father) 1.7 1.8 5.5 -0.6 1.3 -1.5 -0.1 0.9 -0.1 -2.3 2.0
Alzheimer’s Disease (including proxy) 0.9 1.2 3.5 -0.4 1.1 -1.5 -1.0 0.7 0.4 -1.9 1.1
Crohns Disease (2017) 0.5 1.2 7.0 2.6 -0.5 0.0 -1.0 -0.3 0.9 -0.0 -0.9
Irritable Bowel Disease (IBD) 0.5 1.1 4.3 2.1 -0.4 0.4 -1.3 0.4 1.3 0.5 -0.6
Ulcerative Colitis (UC) 0.1 0.2 0.4 0.3 -0.6 0.6 -0.1 0.4 0.6 0.5 -0.2
Major Depression (MDD) 2.0 2.4 7.2 1.6 0.8 2.7 -0.4 0.9 0.2 1.9 -2.0
Reaction Time 1.4 2.7 6.5 2.6 -2.4 1.0 -0.3 -1.0 -1.6 1.8 -1.3
Verbal and Numeric Reasoning (VNR) 3.6 8.7 20.1 -1.6 2.3 -0.0 -3.6 2.9 4.5 -4.4 0.5
Breast Cancer 0.4 1.0 3.3 1.8 -0.1 1.8 -0.3 0.9 0.5 0.6 0.1
Ovarian Cancer 1.9 2.5 6.1 -0.4 -2.5 0.1 -0.8 -2.4 -1.9 -1.8 0.4
Prostate Cancer 0.8 1.1 2.6 -1.5 0.2 -0.4 -1.3 0.9 1.6 -0.0 1.1
Age at First Birth 0.7 1.0 3.6 1.9 -0.6 -1.2 1.5 -0.5 0.4 -0.4 -0.3
Bipolar Disorder (2011) 0.7 0.6 1.3 -0.9 -1.2 0.2 -0.3 -0.7 -1.1 0.5 0.9
Body Mass Index (BMI) (2010) 1.4 1.9 6.6 -0.7 0.8 0.9 -2.6 0.5 2.1 -0.1 -1.6
Coronary Artery Disease (CAD) 1.4 1.7 4.8 1.4 -0.6 1.1 -2.1 -0.8 -0.0 2.2 -0.3
Crohns Disease (2012) 0.5 0.9 3.9 2.0 -0.5 -0.6 -0.8 -0.8 0.7 -0.7 0.3
Mean Putamen Volume 0.5 0.5 1.8 0.2 1.3 -0.2 0.9 0.3 0.0 0.0 -1.2
Fasting Glucose 0.8 0.9 3.9 0.1 -1.7 0.2 -0.5 -0.7 -0.2 2.0 0.2
HbA1C 0.8 0.9 2.0 0.5 0.2 -1.3 -0.9 -0.5 -0.6 -1.4 1.4
HDL Cholesterol 1.2 2.1 6.2 1.5 -0.0 1.4 2.1 0.3 -1.3 2.5 -0.0
LDL Cholesterol 0.5 0.8 3.0 0.8 0.2 0.6 -1.5 -0.5 1.7 -0.2 0.1
Lupus 0.2 0.3 1.6 0.4 -0.2 -0.1 0.2 0.3 -0.4 0.1 -1.3
Neuroticism (2016) 2.2 3.1 11.2 1.3 0.7 3.1 -1.1 0.9 -0.5 3.4 0.1
Primary Biliary Cirrhosis 1.0 1.5 7.4 -0.1 -0.4 0.5 -2.7 -0.3 1.6 0.3 1.1
Rheumatoid Arthritis 0.4 0.6 1.7 -0.1 -0.8 -0.4 0.7 -0.7 -1.3 0.6 1.0
Schizophrenia (2014) 0.6 1.3 6.6 -1.1 -0.3 -0.0 0.6 -0.7 -1.1 2.6 0.3
Triglycerides 1.0 1.6 6.5 -0.2 -0.2 -0.7 -2.5 0.1 1.4 -2.0 0.2
Type 2 Diabetes (T2D) (2012) 1.7 2.0 4.4 -1.1 -1.6 -0.9 1.7 -2.1 -1.7 0.9 -0.7
Ulcerative Colitis 0.5 0.8 2.9 -0.2 -0.2 0.6 -0.9 0.4 1.7 -0.1 -1.3
Blood Eosinophil Count 0.2 1.9 6.6 1.1 -1.0 -2.6 -0.9 -1.1 -0.7 0.1 -2.0
Blood Platelet Count 0.1 1.0 2.6 0.5 -1.2 -0.3 0.9 0.8 0.2 1.6 -1.4
Blood Red Count 0.1 1.2 6.7 -2.6 -0.3 1.0 -0.8 -0.2 0.9 -0.8 0.1
Blood White Count 0.1 0.9 3.9 -1.5 -0.4 0.8 -0.7 -0.2 0.3 2.0 -0.2
Heel T-Score 4.6 36.9 98.6 9.7 2.5 -2.4 -9.9 3.6 4.2 -1.4 -7.6
BMI 0.4 2.5 7.1 -0.7 1.8 1.2 -0.8 2.2 2.7 1.0 -1.0
Height 0.2 4.2 23.3 4.8 0.6 1.1 -0.3 2.1 1.1 0.9 -1.5
Waist Hip Ratio (WHR) 1.2 5.5 15.8 3.3 -1.4 2.0 0.3 -0.8 -2.2 4.0 -2.3
Systolic Blood Pressure 1.2 6.0 13.5 -3.6 3.7 -1.2 -0.5 1.9 3.0 -2.5 1.2
Smoking Status 4.6 11.0 56.1 7.5 -2.5 1.0 0.7 -0.0 -3.4 3.3 -0.9
Allergy or Eczema 0.1 0.3 1.4 1.2 0.2 0.4 -0.5 0.3 -0.1 0.5 -0.1
Cardiovascular Disease 0.6 1.8 10.8 -0.2 1.1 -0.2 -0.1 0.5 0.9 3.3 -1.2
Hypothyroidism (self reported) 0.5 1.2 3.1 0.8 -0.9 -1.8 1.1 -1.4 -1.0 0.7 -0.7
Respiratory disease 0.2 0.5 1.1 -1.0 0.7 0.1 1.0 0.3 0.0 1.0 -0.7
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.0 0.3 -0.5 -1.1 -1.4 -0.2 0.4 0.6 -1.3
Lung FEV1/FVC ratio 0.3 1.3 4.0 -2.0 0.1 -1.0 0.2 0.0 0.1 -1.2 1.9
Lung FVC 0.5 2.7 9.9 -1.9 1.9 0.5 0.1 3.1 1.7 -1.1 0.2
Neuroticism 4.0 9.7 54.5 3.4 0.6 2.5 -1.0 1.6 0.5 7.4 -1.1
Chronotype (morning person) 3.3 7.6 22.2 -3.9 4.7 1.1 0.9 3.3 2.7 1.6 0.7
Hair Pigment 0.0 0.5 3.0 0.8 -0.4 0.3 0.5 0.0 -0.3 1.7 0.2
Tanning 0.1 1.2 3.6 1.6 -0.8 -0.5 0.2 -1.9 -1.2 -0.6 0.9
Hand grip strength (left) 0.5 1.4 3.1 1.8 -1.5 0.1 0.7 -1.1 -1.6 1.0 -0.9
Number of treatments/medications taken 0.4 0.7 3.5 -0.4 0.6 -0.4 0.2 0.8 0.0 1.9 -0.7
Average weekly spirits intake 0.3 0.3 0.7 0.9 0.7 -0.6 0.3 -0.0 -0.0 0.8 -0.6
Sensitivity / hurt feelings 3.2 5.4 20.2 2.3 1.6 2.3 -0.5 2.9 1.0 4.5 0.1
Frequency of depressed mood in last 2 weeks 1.7 2.4 16.3 0.3 0.5 0.7 -1.3 0.7 -0.5 4.0 -0.0
Hearing difficulty/problems: Yes 0.7 1.1 3.6 -0.5 1.3 -0.6 -0.2 1.0 1.5 0.2 1.9
Relative age of first facial hair 0.3 0.5 2.4 0.0 0.3 0.0 -0.8 0.1 1.0 0.0 -1.5
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 4.7 -0.1 0.3 2.1 -1.0 1.5 1.3 2.2 -1.6
Ever used hormone-replacement therapy (HRT) 1.5 1.9 7.0 1.9 0.4 0.8 -2.7 1.0 1.4 0.6 -0.4
Ever had hysterectomy (womb removed) 0.7 0.8 2.8 1.1 -0.5 1.3 -0.2 0.3 -0.3 1.7 -0.2
Systolic blood pressure, automated reading 2.4 7.1 15.6 -3.5 4.0 -0.6 -0.4 3.0 2.6 -3.1 1.7
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.9 0.1 0.6 1.0 0.4 0.5 -0.8 0.3 1.7
Angina 1.2 1.6 3.2 1.1 1.3 0.9 -1.2 1.8 1.7 1.0 -0.5
Medication for hormone replacement therapy 1.5 1.7 6.3 1.6 -1.5 -0.9 -2.5 -0.5 0.2 1.2 -0.4
Vitamin and mineral supplements 2.7 3.6 11.6 -0.1 3.4 0.3 -1.6 3.3 1.7 -0.9 0.7
Supplements: Zinc 1.5 1.6 4.0 0.6 -0.7 -1.4 1.4 -1.0 -2.0 -1.3 1.3
Medication: Co-codamol 0.7 0.8 3.6 -1.1 -0.3 -1.9 0.7 -0.2 0.3 -0.7 -0.5
Medication: Metformin 0.7 1.0 2.5 -0.8 1.0 0.1 -1.4 1.0 1.6 0.7 0.4
Diabetes (father) 0.5 0.6 1.8 -0.6 0.5 -0.3 1.3 -0.1 0.2 1.4 -0.5
Diabetes (mother) 1.1 1.4 4.3 1.2 -0.5 0.7 0.8 -0.9 -1.8 2.1 0.1
Severe depression (siblings) 0.9 1.1 4.1 0.1 -0.8 0.2 1.1 -1.5 -2.0 -0.2 0.3
Pack years adult smoking proportion 1.7 2.7 9.5 0.2 0.0 1.7 -3.1 -0.3 1.9 0.5 -2.3
Impedance of leg (right) 1.3 6.2 13.2 3.6 -2.3 2.1 0.5 -2.6 -1.6 2.1 -3.6
Leg fat-free mass (left) 0.4 1.9 5.8 -0.0 2.1 0.9 -0.8 2.4 1.8 0.8 -0.1
Trunk fat percentage 1.2 5.0 9.2 -0.5 2.9 1.9 -0.2 3.0 3.0 1.3 -2.8
Hand grip strength (right) 0.1 0.4 1.1 0.5 -0.6 0.8 0.1 0.0 0.3 1.0 -0.6
Townsend deprivation index at recruitment 0.7 1.0 4.4 2.1 -0.3 -0.2 0.7 0.3 -0.2 -0.7 -1.6
Current tobacco smoking 2.3 3.8 15.2 3.9 -2.4 -0.4 0.4 -0.9 -2.2 1.6 -1.0
Average weekly fortified wine intake 1.2 1.3 7.2 -2.7 1.1 0.4 1.2 0.3 0.0 0.1 0.9
Maternal smoking around birth 2.0 2.9 7.2 1.4 0.3 2.7 -2.3 1.6 1.6 1.7 -0.8
Fed-up feelings 2.8 5.1 19.3 1.8 1.3 2.0 -1.8 2.0 1.6 4.4 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 2.5 3.3 14.6 2.4 -0.1 1.2 -0.5 0.6 -0.4 3.8 -1.9
Relative age voice broke 0.5 0.7 1.5 -1.2 1.2 -0.1 -0.7 0.6 1.2 0.0 0.9
Taking other prescription medications 0.5 0.7 4.9 0.0 -0.5 -0.3 0.5 -0.1 0.4 2.2 -0.1
Age when periods started (menarche) 0.4 1.1 2.4 0.8 -0.9 -0.2 1.3 -1.6 -1.5 0.7 0.4
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.6 0.5 -0.5 0.8 0.3 -0.4 -0.8 0.8 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 2.6 6.0 12.6 3.3 0.9 -2.5 -3.5 1.9 1.6 -0.6 -3.2
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 5.9 0.0 0.7 -0.3 0.7 0.1 0.5 0.7 -2.4
Qualifications: CSEs or equivalent 1.5 2.0 3.6 -0.6 -0.9 1.9 1.8 -0.3 -1.9 1.2 -1.7
Serious illness, injury or assault to yourself 0.9 1.1 5.1 -2.3 0.4 -1.1 0.2 -0.3 -0.5 -1.2 -0.9
High blood pressure 0.9 2.4 6.0 -1.0 2.5 -0.2 -0.6 2.4 1.6 1.7 0.9
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.0 1.0 -0.1 0.3 -0.4 0.4 0.1 1.1 -1.4
Multivitamins +/- minerals 2.1 2.7 7.8 -0.2 -2.6 -0.9 2.0 -2.8 -1.4 0.6 -0.1
Stomach or abdominal pain in last month 1.2 1.5 2.6 1.0 -0.5 -0.8 1.3 -1.2 -1.3 1.6 1.5
Supplements: Glucosamine 0.6 0.7 2.5 1.3 -0.4 -0.1 1.1 -1.6 -0.4 -0.0 -0.3
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 4.9 -0.8 -1.3 -1.6 -1.0 -1.0 0.3 1.9 2.2
Medication: Atenolol 0.6 0.8 5.7 0.4 0.2 0.5 0.2 0.2 -0.3 -0.3 -2.4
Medication: Levothyroxine sodium 0.8 1.3 5.9 0.3 -0.5 -2.4 1.1 -1.2 -1.3 -0.2 -0.3
Sitting height 0.5 3.9 19.4 4.4 -0.1 1.9 0.8 1.4 0.5 2.1 -0.8
Chronic bronchitis/emphysema (father) 0.9 1.0 1.9 0.8 0.3 0.9 -1.4 1.0 1.3 1.2 -0.6
High blood pressure (mother) 0.4 0.6 2.2 -0.0 -1.5 -1.0 -0.5 -0.6 0.1 0.9 0.3
Body mass index (BMI) 1.2 4.9 10.9 -2.4 3.3 0.6 -1.3 3.1 3.1 0.7 -1.1
Impedance of leg (left) 1.0 4.7 9.3 3.1 -2.3 1.8 0.3 -2.1 -1.2 2.4 -2.9
Leg predicted mass (left) 0.3 1.8 5.7 -0.0 2.1 0.9 -0.7 2.4 1.6 0.8 -0.0
Trunk fat mass 1.3 5.4 10.9 -0.3 3.0 1.9 -0.6 3.3 3.1 1.9 -2.4
Waist circumference 1.4 5.2 11.6 -1.1 3.4 1.9 -1.2 3.3 2.6 1.9 -1.4
Number of incorrect matches in round 0.5 0.8 2.7 0.1 -0.5 0.4 0.6 -1.1 -1.1 1.6 0.4
Past tobacco smoking 3.8 7.1 34.3 -5.9 1.6 -0.4 -1.5 -0.8 3.0 -2.3 -1.4
Alcohol usually taken with meals 3.4 5.5 14.9 -3.2 -1.1 -3.9 0.7 -1.7 -1.4 -3.3 1.1
Nervous feelings 1.2 2.3 6.4 -0.8 -0.0 1.7 2.3 -0.2 -1.6 2.5 0.6
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 12.5 1.4 0.4 0.8 -0.6 0.4 -0.6 3.5 -0.3
Hearing difficulty/problems with background noise 0.6 1.0 3.8 -1.1 -0.4 0.6 1.5 -0.2 0.1 2.0 0.5
Hair/balding pattern: Pattern 2 0.2 0.3 0.6 0.3 0.8 0.3 -0.7 0.6 0.2 0.3 -0.6
Had menopause 1.1 1.4 4.2 0.9 1.5 0.5 -1.2 2.0 1.5 -0.1 -0.3
Had other major operations 2.4 2.9 9.0 -1.0 2.0 1.0 -1.6 3.0 1.9 1.4 -0.4
Forced vital capacity (FVC) 0.1 0.5 2.2 1.0 -0.1 -0.1 1.5 0.6 -0.7 0.2 0.0
Heel bone mineral density (BMD) T-score, automated (right) 3.2 7.2 13.8 3.7 1.5 -1.9 -3.7 2.4 2.2 -0.7 -3.7
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.1 0.1 0.2 0.4 -0.4 0.9 0.2 -0.6 -1.4
Qualifications: None of the above 1.1 2.4 5.7 1.5 1.6 2.4 1.3 1.9 0.6 1.6 -0.7
Financial difficulties in last 2 years 1.1 1.5 6.7 -0.5 1.6 -0.1 1.2 0.7 0.7 2.6 0.3
Mouth/teeth dental problems 0.5 0.8 2.7 -0.0 0.3 -0.6 -0.1 0.5 1.6 -1.3 -1.0
Heart attack 0.1 0.2 0.7 0.5 0.0 0.0 -0.8 0.3 0.1 0.1 -0.5
Allergy 0.2 0.4 1.9 -0.2 0.2 0.1 -0.4 -0.4 0.5 -1.4 0.9
Pain all over the body in last month 1.3 1.4 3.5 -0.6 1.9 1.5 1.4 1.7 0.3 0.0 -0.1
Diabetes (self-reported) 0.5 0.7 1.8 0.2 0.5 0.3 -1.3 0.8 1.3 0.4 -1.2
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.0 -0.6 -0.6 -0.4 1.0 -0.9 -0.9 -0.4 -0.1
Medication: Ramipril 0.7 0.9 5.0 -0.5 -0.5 -0.7 0.0 -0.9 0.2 0.3 -2.2
Medication: Simvastatin 0.8 1.2 4.1 -0.5 2.0 0.4 -0.1 1.5 0.5 1.3 0.8
Fluid intelligence score 3.0 6.2 15.1 -0.9 1.8 0.8 -3.6 2.4 3.9 -3.3 0.0
Illnesses of siblings 0.2 0.2 0.9 0.3 -0.3 -0.0 0.5 0.6 0.9 -0.4 0.5
Neuroticism score 3.5 7.4 41.0 2.7 0.4 2.4 -0.9 1.6 0.6 6.4 -1.0
Weight 1.0 5.1 11.4 -0.6 3.1 1.6 -1.2 3.4 3.2 1.8 -1.5
Impedance of arm (right) 0.5 2.3 5.2 2.3 -1.5 0.4 1.7 -1.5 -1.4 0.3 -1.9
Arm fat percentage (right) 1.3 5.3 11.6 -1.2 3.4 1.6 -0.2 3.3 3.1 1.3 -2.2
Trunk fat-free mass 0.4 2.1 5.0 0.9 1.4 1.2 -1.2 1.9 1.5 2.2 0.6
Hip circumference 1.2 5.2 11.3 -1.6 3.4 1.1 -0.8 3.2 3.4 0.9 -1.9
Time employed in main current job 0.5 0.6 1.9 0.1 -1.3 -0.3 -0.3 -0.6 -0.8 -0.2 -1.4
Alcohol intake versus 10 years previously 0.2 0.4 1.6 -0.4 0.0 -1.2 0.1 -0.4 -0.2 -1.0 -0.0
Father’s age at death 1.0 1.3 2.8 -0.8 0.7 1.4 -0.6 1.5 1.7 -0.9 1.0
Worrier / anxious feelings 0.7 1.3 5.7 1.0 -0.2 0.9 -1.1 0.1 -0.4 2.4 -1.2
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 6.2 2.0 -0.6 -0.1 -0.2 -0.2 -1.4 2.5 -0.3
Falls in the last year 0.8 1.1 4.1 -1.0 -0.3 -2.0 -0.1 -1.2 -0.7 -1.3 0.5
Hair/balding pattern: Pattern 3 0.6 0.8 2.8 0.6 -0.2 1.7 1.2 -0.7 -0.7 0.7 0.6
Number of live births 1.2 1.7 4.9 0.3 -1.4 -1.3 0.1 -2.0 -2.2 -0.4 -1.0
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.8 -0.7 0.4 -0.2 0.9 0.9 0.3 -0.2 0.5
Pulse rate 0.5 0.8 2.6 -0.3 0.6 -1.0 1.0 1.1 -0.0 0.7 1.6
Happiness 0.9 1.1 3.1 1.8 -0.7 1.3 -0.5 -0.1 -0.6 1.5 -0.7
Noisy workplace 1.2 1.5 4.0 2.0 -0.7 -1.3 -0.3 -1.2 -0.1 1.4 -1.4
Qualifications: A levels/AS levels or equivalent 1.5 3.3 8.1 -1.4 -0.1 -2.5 -2.2 -0.7 1.5 -2.8 1.6
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.5 5.6 -1.2 -0.9 -2.2 -0.4 -1.1 -1.2 -2.0 2.4
Mouth/teeth dental problems: Dentures 1.7 2.9 9.9 1.0 -1.6 0.9 1.9 -1.2 -1.5 3.1 -1.2
Asthma 0.5 1.0 2.8 -1.7 0.4 -0.5 1.6 -0.5 -0.9 0.5 -0.9
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.3 4.0 0.2 1.3 0.4 -2.0 1.2 1.7 -0.0 -0.6
Medication: Cholesterol lowering 0.3 0.5 1.6 -0.2 0.2 0.5 1.1 0.2 -0.4 1.3 0.6
Depression (self-reported) 1.0 1.2 4.0 -0.9 0.2 2.0 -1.0 -0.1 -0.6 1.4 -1.2
Medication: Lansoprazole 1.0 1.1 3.0 1.7 -0.4 0.5 -1.5 -0.0 0.5 1.3 -1.2
Prospective memory result 2.1 2.6 9.9 -1.1 -0.2 -0.4 0.8 -1.7 -1.8 3.1 1.7
Lung cancer (father) 0.5 0.5 1.5 1.2 -0.2 0.9 1.0 0.6 0.3 0.7 0.2
Illnesses of mother 0.8 0.9 3.1 1.8 -0.0 1.2 0.9 -1.3 -0.4 0.7 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.6 -0.4 1.2 -0.6 0.0 1.9 0.9 -0.2 0.7
Pulse wave Arterial Stiffness index 1.3 1.6 3.6 1.7 0.6 0.9 1.7 0.1 -1.9 1.0 -1.1
Impedance of arm (left) 0.6 2.8 5.2 2.2 -1.5 0.2 2.3 -1.6 -1.8 -0.5 -1.8
Arm fat mass (right) 1.5 6.1 13.8 -0.7 3.6 1.8 -0.8 3.7 3.3 1.8 -2.0
Trunk predicted mass 0.4 2.1 4.9 1.0 1.5 1.1 -1.1 1.9 1.4 2.2 0.7
Standing height 0.3 3.4 14.4 3.8 -0.3 2.4 -0.1 0.9 0.4 2.4 -0.8
Length of working week for main job 1.7 1.9 4.0 1.2 -1.3 -1.3 -1.4 -2.0 -1.3 0.6 1.5
Exposure to tobacco smoke at home 0.9 1.0 5.8 -0.2 0.3 0.6 1.2 -0.3 -2.4 0.4 0.2
Breastfed as a baby 2.2 2.7 6.2 -1.0 2.0 1.8 -0.5 2.5 1.6 -1.7 -1.1
Tense / ‘highly strung’ 1.1 1.9 11.7 0.3 -0.4 1.1 -0.0 0.5 -0.3 3.4 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.1 8.8 1.0 -0.4 2.1 -0.7 0.1 0.2 3.0 -1.2
Hair/balding pattern: Pattern 4 0.4 0.9 4.0 0.5 -0.5 0.2 1.4 0.4 -0.3 2.0 -0.7
Birth weight of first child 1.6 2.9 6.7 2.3 0.4 2.5 1.7 1.4 -0.4 2.6 -0.4
Peak expiratory flow (PEF) 0.1 0.3 0.7 -0.8 -0.9 0.1 0.5 -0.3 -0.3 -0.6 0.6
Pulse wave reflection index 0.8 1.0 2.4 1.4 0.3 1.6 0.8 0.0 -1.2 0.8 -1.0
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.1 0.9 -0.2 -0.6 0.1 -0.3 -0.3 1.0 0.2
Loud music exposure frequency 1.2 1.4 4.0 -1.5 -0.5 -0.8 0.6 -2.0 -1.8 0.2 0.0
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.3 0.6 -1.5 -1.1 -1.0 -1.4 -0.8 -0.8 0.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.8 -0.0 0.3 0.3 -0.4 -0.5 -0.9 0.4 0.5
Blood clot in the leg (DVT) 0.5 0.6 1.6 -1.0 0.6 -1.0 -0.0 0.6 1.3 0.8 -0.0
Medication: Paracetamol 0.6 0.9 4.3 1.1 -0.9 -0.1 -2.1 0.2 -0.8 0.5 -0.4
Headache pain in last month 1.1 2.0 4.8 0.8 -1.4 0.7 0.2 -1.5 -1.9 1.5 -2.2
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 2.4 0.7 -1.2 -0.9 -1.5 -1.4 -0.8 -1.0 -1.0
Glaucoma (self-reported) 0.6 0.7 2.0 0.8 -1.3 0.9 -0.8 -0.1 0.2 -0.1 -1.4
Gout (self-reported) 0.7 0.9 3.9 0.2 2.0 0.5 0.3 1.2 1.2 -0.3 0.4
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 2.3 0.6 -0.5 -1.5 0.8 -1.0 -0.5 0.7 -0.2
Medication: Amlodipine 0.3 0.4 0.8 -0.6 0.8 0.2 0.7 0.8 0.3 0.2 0.9
Medication: Ventolin 100micrograms inhaler 1.1 1.4 7.8 -0.1 -0.3 0.7 2.8 -0.5 -1.5 0.1 0.2
Birth weight 0.5 1.1 5.1 1.4 -0.5 0.9 0.0 -0.0 -0.7 2.3 -0.3
Chronic bronchitis/emphysema (mother) 2.5 3.0 7.9 1.9 -1.0 1.4 -0.9 0.1 -0.5 2.8 -2.8
High blood pressure (siblings) 0.2 0.4 0.8 -0.6 0.1 0.9 -0.8 -0.5 -0.6 -0.1 0.7
Forced vital capacity (FVC), Best measure 0.2 0.7 2.3 1.5 0.6 -0.1 0.3 1.5 -0.0 0.6 0.1
Body fat percentage 1.4 5.5 9.4 -0.7 3.0 2.1 -0.4 3.0 3.1 1.6 -3.0
Leg fat percentage (right) 1.5 5.3 8.3 -0.9 2.9 2.1 -0.9 2.6 2.7 2.4 -2.8
Arm fat-free mass (right) 0.5 2.7 6.6 0.1 2.0 1.0 -1.6 2.6 2.2 1.5 -0.2
Exposure to tobacco smoke outside home 0.6 0.7 2.5 -0.6 0.3 -0.4 1.6 -0.6 -0.2 1.6 0.1
Comparative body size at age 10 0.6 1.8 4.5 -1.9 2.0 -0.1 -0.6 1.3 2.1 -0.0 0.3
Number of full brothers 0.7 0.8 2.9 1.0 0.8 0.1 -1.3 -0.2 -0.1 -0.1 -1.7
Worry too long after embarrassment 2.6 4.4 20.1 1.5 1.1 2.4 -0.6 1.2 0.6 4.5 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.6 5.5 0.5 -0.5 1.6 -0.2 -1.0 -1.1 2.4 -1.5
Wheeze or whistling in the chest in last year 1.1 2.0 3.7 1.6 -1.5 0.7 1.7 -1.2 -1.9 1.6 -0.3
Number of children fathered 0.3 0.4 1.9 0.6 0.3 1.4 0.3 0.7 -0.1 0.1 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.6 -1.2 0.7 1.1 0.5 0.5 -0.2 0.4 1.3
Age at first live birth 1.0 1.8 7.7 0.6 0.7 -2.8 1.0 -0.3 -0.3 0.1 2.2
Pulse wave peak to peak time 1.3 1.6 4.4 -1.6 -0.4 -0.7 -1.8 0.2 2.1 -0.7 1.1
Health satisfaction 2.0 2.6 10.2 1.9 -0.5 1.7 -0.4 -1.2 -1.4 3.2 -0.2
Shortness of breath walking on level ground 1.9 2.3 6.4 0.7 -1.8 -0.5 1.2 -1.6 -2.5 1.9 -0.6
Qualifications: College or University degree 0.7 2.3 4.9 -2.2 0.1 -1.9 -0.9 -0.3 1.2 -1.9 1.9
Eye problems/disorders: None of the above 0.9 1.1 5.6 0.3 2.4 1.1 -0.2 1.1 0.6 -0.2 -0.3
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 -0.0 -0.4 -0.4 -0.1 0.1 -0.2 -0.2 0.6
Emphysema/chronic bronchitis 1.3 1.5 3.9 0.5 -2.0 0.1 0.3 -1.0 -1.5 2.0 -0.8
Medication for pain relief, constipation, heartburn 0.4 0.7 1.8 -1.1 0.3 0.3 1.4 -0.6 0.2 -0.8 1.2
Neck or shoulder pain in last month 0.8 1.1 2.9 1.7 -1.1 0.0 -1.6 -0.4 0.9 -0.1 -1.0
Medication: Blood pressure 1.2 2.0 5.6 -1.0 2.2 0.7 0.4 2.4 1.9 0.3 0.8
Angina (self-reported) 1.1 1.4 2.9 1.1 1.3 1.0 -1.1 1.7 1.4 0.9 -0.6
Migraine (self-reported) 1.0 1.2 6.6 0.6 0.0 0.3 -0.8 -0.1 0.8 1.2 -2.6
Medication: Ibuprofen 1.1 1.4 3.9 -0.1 1.1 0.6 -2.0 1.1 2.0 -0.1 0.4
Medication: Allopurinol 1.4 1.8 7.1 0.4 2.7 0.2 -0.2 2.1 1.4 -0.6 0.7
Medication: Omeprazole 1.0 1.1 2.6 -0.3 0.8 1.4 -0.2 1.0 1.6 0.6 -1.5
Medication: Seretide 50 evohaler 1.0 1.1 3.0 -0.5 -1.7 0.1 1.1 -1.3 -1.2 0.1 -1.1
Mean time to correctly identify matches 0.5 0.9 3.8 1.9 -1.0 1.0 -0.3 0.3 -0.5 0.7 -0.5
Heart disease (mother) 1.6 1.9 12.7 -3.6 1.1 -0.2 0.3 0.4 -0.2 0.3 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.7 3.2 10.3 0.8 -2.7 0.1 0.1 -3.2 -2.3 -0.4 -1.3
Whole body fat mass 1.4 5.9 11.2 -0.4 3.1 1.9 -0.9 3.3 3.2 2.3 -2.4
Leg fat mass (right) 1.5 5.7 9.5 -0.7 3.1 1.9 -1.3 3.0 3.1 2.4 -2.5
Arm predicted mass (right) 0.4 2.2 5.2 0.1 1.8 1.1 -1.6 2.3 2.0 1.2 0.0
Pulse rate, automated reading 1.0 3.1 10.5 0.5 2.4 0.7 2.5 3.2 0.7 0.8 0.9
Alcohol intake frequency. 1.6 3.7 12.6 -2.1 -1.9 -2.2 -1.1 -1.6 -0.5 -3.6 0.4
Comparative height size at age 10 0.6 3.2 12.2 2.8 -0.6 1.5 1.0 1.0 0.8 3.5 0.6
Number of full sisters 0.8 0.9 3.2 -0.7 -1.3 -0.8 0.3 -0.9 -1.8 -0.9 0.1
Suffer from ‘nerves’ 1.4 2.2 9.9 0.8 -0.3 -0.3 2.1 -0.9 -1.0 3.1 -0.5
Overall health rating 1.2 2.6 19.0 0.2 -0.1 1.1 0.3 -0.1 -0.3 4.4 -0.8
Chest pain or discomfort 0.6 0.8 2.2 1.5 0.8 1.2 -0.2 1.1 0.2 1.1 -0.1
Had major operations 0.5 0.6 1.8 0.3 -0.5 -0.3 -1.3 -0.6 -0.8 -0.9 0.7
Age at last live birth 2.2 3.2 11.7 0.5 0.1 -3.4 0.2 -1.2 -1.1 -1.2 3.1
Family relationship satisfaction 0.6 0.8 2.3 -0.1 -0.4 1.4 -1.1 -0.3 0.5 1.5 0.1
Leg pain on walking 0.6 0.7 3.5 1.9 -0.4 -0.5 0.4 0.2 -0.1 0.8 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.6 1.3 0.2 0.6 0.5 0.5 -0.3 1.6 -0.8
Commuting to job workplace: Car/motor vehicle 0.6 0.6 2.7 0.4 -0.8 0.1 -0.3 -0.7 -1.0 0.1 -1.6
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 7.0 1.5 -0.3 2.6 0.2 0.4 0.0 2.6 -0.5
Medication: Aspirin 0.6 0.8 2.3 -1.3 0.7 0.0 0.1 0.8 0.2 1.1 -1.5
Supplements: Vitamin C 0.4 0.4 1.8 1.4 -0.7 -0.0 0.3 -0.6 -0.1 0.2 0.8
Knee pain experienced in last month 1.2 1.8 4.1 1.3 -0.9 -0.8 -2.0 -1.2 0.9 1.6 -1.6
Hypertension (Self-reported) 1.0 2.9 6.8 -1.1 2.6 -0.6 -0.8 2.5 2.0 1.6 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 7.5 2.7 -0.9 0.8 0.4 0.3 -0.4 2.0 -0.6
Illnesses of father: Heart disease 0.4 0.5 3.3 -1.8 0.5 0.2 0.2 0.1 -0.2 0.5 0.3
Illnesses of siblings: Diabetes 0.7 0.9 3.0 -0.8 1.7 -1.2 0.2 0.9 -0.6 -0.3 -0.7
Smoking status: Previous 3.0 4.5 22.5 4.7 -0.9 0.6 0.8 0.9 -2.3 1.4 1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.2 0.8 -0.6 0.9 0.8 -0.6 -1.2 1.8 0.5
Whole body fat-free mass 0.4 2.2 5.5 0.4 1.8 1.1 -1.1 2.3 1.7 1.7 0.4
Leg fat-free mass (right) 0.4 2.0 7.0 -0.4 2.1 0.5 -0.9 2.6 1.8 0.6 0.6
Arm fat percentage (left) 1.2 5.0 11.4 -1.3 3.4 1.3 -0.2 3.2 3.0 0.8 -2.2
Average weekly red wine intake 1.4 2.1 6.2 -0.3 -2.1 -2.5 -0.7 -1.6 0.6 -1.6 0.4
Handedness (chirality/laterality): Left-handed 3.6 4.4 8.7 1.3 -2.5 0.6 0.8 -2.9 -2.1 2.4 -2.7
Mood swings 2.8 5.1 20.4 2.0 1.2 2.5 -2.1 1.4 1.7 4.5 0.0
Loneliness, isolation 3.0 4.2 12.7 2.9 0.5 1.6 -1.2 1.5 0.5 3.6 -2.4
Long-standing illness, disability or infirmity 0.6 0.9 2.5 -0.5 0.4 -0.4 -1.5 0.5 0.9 1.6 0.6
Ever had bowel cancer screening 1.5 1.8 6.0 1.8 0.3 2.4 0.4 1.2 1.4 0.2 -1.1
Diabetes diagnosed by doctor 0.7 1.2 3.2 -0.2 0.4 1.2 -1.4 0.9 1.0 0.9 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 3.4 -0.7 -0.3 -1.9 0.4 -0.1 0.6 -0.2 0.7
Friendships satisfaction 2.4 3.0 9.4 1.3 1.4 3.1 0.3 0.8 0.4 3.0 0.7
Qualifications: nursing, teaching 0.9 1.4 3.2 -1.7 -0.2 -1.8 -1.8 -0.2 -0.2 -0.6 1.1
Commuting to job workplace: Walk 1.0 1.1 4.1 -1.2 -0.4 0.1 -1.2 -0.4 2.0 -0.5 0.9
Eye problems/disorders: Cataract 1.8 2.1 6.9 0.1 -2.6 -2.0 -0.3 -1.5 -1.3 1.1 0.7
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 4.4 0.6 1.1 1.1 -1.9 1.3 0.4 -0.8 2.1
Medication for cholesterol 2.4 3.7 13.5 0.0 -0.8 -0.3 3.7 -1.8 -2.0 -2.1 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 3.7 0.7 0.9 -0.8 -0.4 0.5 0.3 1.9 -0.7
Back pain experienced in last month 0.7 1.1 3.1 1.8 -1.3 0.2 -0.3 -1.3 -0.9 0.7 -0.8
Mineral and other dietary supplements 1.6 2.2 5.2 -0.9 1.3 -0.2 -2.3 2.2 1.1 -1.8 0.1
Breast cancer (self-reported) 1.1 1.4 4.4 -0.9 2.1 0.7 0.0 1.7 1.3 -0.0 -0.8
Asthma (self-reported) 0.5 1.0 3.5 -1.9 0.5 -0.6 1.6 -0.4 -0.8 0.3 -0.9
Osteoporosis (self-reported) 1.0 1.3 3.4 0.4 -1.2 1.1 1.2 -1.0 -1.8 1.1 -0.6
Osteoarthritis (self-reported) 0.6 0.7 2.8 -1.7 0.2 1.0 -0.1 0.2 0.2 1.1 1.0
Medication: Aspirin 0.7 0.9 3.3 -1.1 0.5 -0.1 0.4 0.7 0.0 1.4 -1.8
Medication: Gliclazide 0.2 0.2 0.8 0.2 0.4 -0.1 -0.7 0.2 0.9 0.3 0.2
Illnesses of father: None of the above (group 1) 0.7 0.9 2.9 1.5 -0.9 1.7 0.7 -0.6 0.0 0.3 -0.3
Smoking status: Current 2.5 3.9 15.6 3.9 -2.5 -0.2 0.3 -0.9 -2.0 1.4 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 6.5 -2.5 0.4 -0.3 0.9 0.2 0.3 -0.5 0.8
Whole body water mass 0.4 2.4 6.2 0.3 1.9 1.1 -1.2 2.5 1.9 1.6 0.5
Leg predicted mass (right) 0.4 2.0 7.0 -0.4 2.1 0.5 -0.8 2.6 1.7 0.6 0.6
Arm fat mass (left) 1.5 6.3 14.3 -0.9 3.7 1.6 -0.9 3.8 3.6 1.4 -2.0
Number of self-reported non-cancer illnesses 0.6 1.0 2.2 -1.4 0.7 0.7 -0.7 1.3 0.5 1.5 -0.4
Average weekly champagne plus white wine intake 0.6 0.9 3.3 1.1 -0.1 0.4 0.2 -0.8 -0.5 1.1 1.8
Miserableness 4.0 7.0 28.9 3.8 0.4 2.8 -0.5 1.5 0.4 5.4 -1.3
Guilty feelings 4.2 6.4 31.4 2.2 0.2 3.5 -0.5 1.1 0.1 5.6 -1.0
Wears glasses or contact lenses 1.5 1.7 3.8 -1.8 2.0 0.3 -1.4 1.4 0.8 0.4 1.4
Ever taken oral contraceptive pill 0.8 0.9 3.0 0.7 0.6 1.7 -0.9 1.3 0.6 0.4 -0.6
Hearing aid user 2.5 2.8 11.0 -1.8 0.8 -0.3 -1.2 0.6 1.8 -1.6 3.3
Mother’s age at death 1.6 2.0 4.3 -1.3 -0.6 -1.2 -1.9 -0.0 1.5 -1.4 -2.1
Financial situation satisfaction 1.0 1.2 4.6 1.9 -0.5 0.5 0.6 -0.3 -1.0 2.1 -0.1
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.8 0.1 -0.0 0.6 0.3 -0.4 0.7 0.2 1.7
Commuting to job workplace: Public transport 1.1 1.4 6.7 -0.2 0.1 -0.2 0.2 0.8 1.7 -0.8 2.6
Eye problems/disorders: Glaucoma 0.3 0.3 2.0 -0.0 -1.4 0.5 -0.3 -0.1 -0.2 0.1 -0.6
Medication: Blood pressure 0.9 1.8 2.7 -1.3 1.6 -0.4 -1.6 1.6 1.6 0.6 -1.3
Pain type(s) experienced in last month: Hip pain 1.5 1.8 5.4 1.6 -0.9 0.5 -1.9 -0.1 1.1 2.3 -1.1
Supplements: Fish oil (including cod liver oil) 1.5 1.9 6.6 0.4 -1.0 -0.7 2.6 -2.0 -1.4 1.1 -0.1
High cholesterol (Self-reported) 0.8 1.5 6.5 -0.1 0.9 1.1 0.4 1.5 0.8 2.5 -0.8
Medication: Bendroflumethiazide 1.4 2.2 5.3 -0.4 2.2 0.1 -1.4 2.2 2.3 0.5 0.2
Medication: Paracetamol 0.4 0.6 2.0 0.8 -1.4 -0.4 -1.3 -0.2 -0.6 0.3 0.4
Medication: Lisinopril 0.8 1.0 2.4 -1.3 1.5 -1.6 -0.5 0.5 0.2 -0.5 0.8
Medication: Atorvastatin 0.6 0.8 3.2 1.0 -0.3 0.1 0.6 0.4 -0.4 1.1 -1.8
Illnesses of father: High blood pressure 1.3 1.6 6.8 -1.4 0.1 -2.6 -1.1 -1.5 -0.4 -0.6 0.1
Alcohol drinker status: Never 0.7 0.9 3.5 -1.9 -0.4 -0.8 -1.4 -0.4 0.3 -0.3 -0.6
Ever smoked 5.0 8.7 39.1 6.2 -2.4 0.2 1.9 0.2 -3.7 2.4 1.4
Basal metabolic rate 0.5 2.8 6.7 0.3 2.2 1.3 -1.1 2.6 2.2 1.8 -0.1
Leg fat percentage (left) 1.4 5.0 8.8 -1.6 2.8 1.6 -1.2 2.8 3.0 2.1 -2.2
Arm fat-free mass (left) 0.7 3.6 7.9 -0.2 2.5 1.5 -1.4 2.8 2.4 2.1 -0.3
Number of operations (self-reported) 1.6 2.3 6.7 0.0 -0.0 1.6 -2.6 1.0 1.2 2.5 -0.8
Average weekly beer plus cider intake 2.4 3.5 6.0 2.2 2.1 1.7 0.8 2.5 1.2 1.9 -1.9
Irritability 1.8 3.1 11.5 1.6 -0.3 0.6 -2.3 1.4 1.6 3.4 -0.1
Risk taking 0.4 0.6 2.1 -1.4 0.9 -0.1 1.1 0.7 -0.1 -0.6 -0.0
Ever had prostate specific antigen (PSA) test 0.8 1.0 2.6 1.6 -1.2 1.5 0.2 -0.0 1.0 0.5 0.3
Fractured/broken bones in last 5 years 0.7 0.9 1.5 -0.7 -1.1 0.1 0.3 -1.2 -1.2 0.8 1.1
Age started oral contraceptive pill 2.0 2.5 4.6 -1.2 0.7 1.7 -1.6 1.6 2.1 -2.1 -1.0
Diastolic blood pressure, automated reading 0.6 1.9 5.8 -2.0 2.4 -0.3 0.6 1.3 0.2 -1.2 1.4
Ever depressed for a whole week 2.3 2.8 5.6 1.4 1.6 2.3 -1.6 2.4 1.6 1.1 -0.7
Unable to work because of sickness or disability 2.8 3.6 10.7 2.3 -0.6 1.0 1.4 -0.2 -1.0 2.9 -3.3
Commuting to job workplace: Cycle 0.5 0.5 2.5 0.5 -0.5 -1.6 0.4 -0.5 -0.2 -0.3 -0.8
Myopia 0.2 0.3 0.6 -0.3 -0.7 0.8 -0.0 -0.7 0.1 -0.7 -0.3
Vascular/heart problems diagnosed by doctor 0.9 2.5 6.5 0.4 -2.5 -0.3 0.6 -2.5 -1.7 -2.0 0.1
Cholesterol lowering medication 3.0 4.5 13.1 -0.7 3.0 1.2 -1.6 3.6 2.0 1.4 -1.7
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.0 0.1 0.7 1.2 -0.8 0.9 1.7 0.7 -1.2
Pain experienced in last month 1.4 2.3 11.3 -3.4 1.1 -0.5 1.4 1.1 0.2 -0.8 1.3
Supplements: Calcium 1.5 1.6 5.6 0.4 -1.5 0.1 1.5 -2.4 -1.3 0.1 0.9
Basal cell carcinoma (self-reported) 0.9 1.0 3.3 -1.8 -1.2 0.3 0.9 -0.6 -0.0 1.1 -1.0
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.6 0.6 0.2 -0.1 -0.8 0.4 0.0 0.0 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.1 -1.4 0.6 -1.3 0.2 0.5 1.3 0.8 0.1
Heart disease (siblings) 1.5 1.8 4.8 -0.9 2.2 -0.4 -1.4 1.9 0.8 -1.6 -0.2
Alcohol drinker status: Previous 0.3 0.3 1.3 -0.3 -0.4 0.5 -0.6 0.3 -0.1 -0.1 1.2
Pack years of smoking 2.1 3.1 11.1 -0.4 0.4 1.9 -3.3 -0.0 2.3 0.4 -2.0
Impedance of whole body 0.8 4.0 7.3 2.7 -2.2 1.1 1.7 -2.2 -2.0 0.7 -2.6
Leg fat mass (left) 1.6 6.1 11.6 -1.1 3.2 1.6 -1.6 3.2 3.4 2.2 -2.2
Arm predicted mass (left) 0.7 3.6 7.6 0.0 2.4 1.4 -1.6 2.8 2.6 2.0 -0.3