Best TWAS P=1.1e-13 · Best GWAS P=2.14e-13 conditioned to 0.399
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DLST | 0.09 | 0.11 | lasso | 2 | 0.11 | 4.0e-13 | -6.4 | 6.7 | 2.3e-11 | -0.65 | 0.44 | 0.56 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RPS6KL1 | 0.04 | 0.02 | lasso | 5 | 0.02 | 4.8e-04 | 4.7 | -6.4 | 1.2e-10 | 0.67 | 0.12 | 0.67 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | YLPM1 | 0.10 | 0.03 | lasso | 6 | 0.02 | 7.9e-03 | -7.1 | 6.8 | 8.2e-12 | -0.77 | 0.04 | 0.74 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | RPS6KL1 | 0.12 | 0.09 | lasso | 2 | 0.08 | 3.7e-05 | 4.6 | 5.2 | 1.7e-07 | -0.63 | 0.50 | 0.42 | FALSE |
| 5 | GTEx | Colon Sigmoid | MLH3 | 0.17 | 0.02 | enet | 9 | 0.00 | 2.4e-01 | -1.3 | -5.9 | 3.7e-09 | 0.55 | 0.04 | 0.66 | FALSE |
| 6 | GTEx | Esophagus Mucosa | RPS6KL1 | 0.18 | 0.12 | lasso | 5 | 0.12 | 3.3e-08 | -5.2 | 5.4 | 6.4e-08 | -0.73 | 0.24 | 0.75 | FALSE |
| 7 | GTEx | Muscle Skeletal | DLST | 0.28 | 0.26 | enet | 23 | 0.26 | 2.1e-25 | -7.0 | -7.4 | 1.1e-13 | 0.93 | 0.02 | 0.98 | TRUE |
| 8 | GTEx | Nerve Tibial | YLPM1 | 0.08 | 0.06 | lasso | 1 | 0.04 | 5.1e-04 | 5.4 | 5.4 | 6.1e-08 | -0.52 | 0.17 | 0.46 | FALSE |
| 9 | GTEx | Nerve Tibial | RPS6KL1 | 0.17 | 0.24 | lasso | 6 | 0.19 | 2.3e-13 | 4.7 | 5.3 | 9.2e-08 | -0.58 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | RPS6KL1 | 0.08 | 0.08 | enet | 11 | 0.07 | 1.5e-04 | 6.3 | 7.2 | 5.2e-13 | -0.71 | 0.22 | 0.75 | FALSE |
| 11 | GTEx | Stomach | RPS6KL1 | 0.09 | -0.01 | enet | 16 | 0.00 | 3.3e-01 | -4.2 | 5.6 | 2.7e-08 | -0.82 | 0.03 | 0.77 | FALSE |
| 12 | GTEx | Testis | AREL1 | 0.20 | 0.14 | enet | 34 | 0.13 | 2.1e-06 | 6.5 | 6.9 | 5.8e-12 | -0.57 | 0.34 | 0.66 | TRUE |
| 13 | METSIM | Adipose | ACYP1 | 0.03 | 0.02 | blup | 413 | 0.02 | 4.0e-04 | -3.1 | 5.4 | 6.9e-08 | -0.64 | 0.55 | 0.39 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS6KL1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 8.5e-06 | 6.5 | 6.3 | 2.5e-10 | -0.57 | 0.46 | 0.53 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS6KL1 | 0.04 | 0.04 | lasso | 3 | 0.03 | 1.8e-04 | 6.4 | 6.1 | 8.0e-10 | -0.59 | 0.34 | 0.47 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RPS6KL1 | 0.09 | 0.10 | blup | 49 | 0.11 | 5.1e-07 | -5.1 | 5.9 | 4.8e-09 | -0.76 | 0.65 | 0.32 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPS6KL1 | 0.03 | 0.01 | blup | 49 | 0.02 | 2.3e-03 | 5.4 | 6.3 | 3.0e-10 | -0.72 | 0.04 | 0.37 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS6KL1 | 0.09 | 0.04 | enet | 6 | 0.06 | 1.1e-06 | 4.7 | 5.2 | 2.6e-07 | -0.55 | 0.81 | 0.18 | FALSE |