[Hub]/) : Traits : Neuroticism (Nagel 2018) :

chr14:74,424,938-76,226,003

Best TWAS P=1.1e-13 · Best GWAS P=2.14e-13 conditioned to 0.399

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DLST 0.09 0.11 lasso 2 0.11 4.0e-13 -6.4 6.7 2.3e-11 -0.65 0.44 0.56 FALSE
2 CommonMind Brain Pre-frontal Cortex RPS6KL1 0.04 0.02 lasso 5 0.02 4.8e-04 4.7 -6.4 1.2e-10 0.67 0.12 0.67 FALSE
3 GTEx Adipose Subcutaneous YLPM1 0.10 0.03 lasso 6 0.02 7.9e-03 -7.1 6.8 8.2e-12 -0.77 0.04 0.74 FALSE
4 GTEx Adipose Visceral Omentum RPS6KL1 0.12 0.09 lasso 2 0.08 3.7e-05 4.6 5.2 1.7e-07 -0.63 0.50 0.42 FALSE
5 GTEx Colon Sigmoid MLH3 0.17 0.02 enet 9 0.00 2.4e-01 -1.3 -5.9 3.7e-09 0.55 0.04 0.66 FALSE
6 GTEx Esophagus Mucosa RPS6KL1 0.18 0.12 lasso 5 0.12 3.3e-08 -5.2 5.4 6.4e-08 -0.73 0.24 0.75 FALSE
7 GTEx Muscle Skeletal DLST 0.28 0.26 enet 23 0.26 2.1e-25 -7.0 -7.4 1.1e-13 0.93 0.02 0.98 TRUE
8 GTEx Nerve Tibial YLPM1 0.08 0.06 lasso 1 0.04 5.1e-04 5.4 5.4 6.1e-08 -0.52 0.17 0.46 FALSE
9 GTEx Nerve Tibial RPS6KL1 0.17 0.24 lasso 6 0.19 2.3e-13 4.7 5.3 9.2e-08 -0.58 1.00 0.00 FALSE
10 GTEx Skin Not Sun Exposed Suprapubic RPS6KL1 0.08 0.08 enet 11 0.07 1.5e-04 6.3 7.2 5.2e-13 -0.71 0.22 0.75 FALSE
11 GTEx Stomach RPS6KL1 0.09 -0.01 enet 16 0.00 3.3e-01 -4.2 5.6 2.7e-08 -0.82 0.03 0.77 FALSE
12 GTEx Testis AREL1 0.20 0.14 enet 34 0.13 2.1e-06 6.5 6.9 5.8e-12 -0.57 0.34 0.66 TRUE
13 METSIM Adipose ACYP1 0.03 0.02 blup 413 0.02 4.0e-04 -3.1 5.4 6.9e-08 -0.64 0.55 0.39 FALSE
14 The Cancer Genome Atlas Breast Invasive Carcinoma RPS6KL1 0.03 0.02 lasso 3 0.02 8.5e-06 6.5 6.3 2.5e-10 -0.57 0.46 0.53 FALSE
15 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RPS6KL1 0.04 0.04 lasso 3 0.03 1.8e-04 6.4 6.1 8.0e-10 -0.59 0.34 0.47 FALSE
16 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RPS6KL1 0.09 0.10 blup 49 0.11 5.1e-07 -5.1 5.9 4.8e-09 -0.76 0.65 0.32 FALSE
17 The Cancer Genome Atlas Lung Adenocarcinoma RPS6KL1 0.03 0.01 blup 49 0.02 2.3e-03 5.4 6.3 3.0e-10 -0.72 0.04 0.37 FALSE
18 The Cancer Genome Atlas Prostate Adenocarcinoma RPS6KL1 0.09 0.04 enet 6 0.06 1.1e-06 4.7 5.2 2.6e-07 -0.55 0.81 0.18 FALSE