Best TWAS P=4.37e-20 · Best GWAS P=1.12e-38 conditioned to 5.66e-16
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | LINC00886 | 0.11 | 0.01 | lasso | 7 | 0.01 | 4.1e-02 | 1.9 | 7.7 | 1.2e-14 | -0.69 | 0.08 | 0.48 | TRUE |
2 | METSIM | Adipose | LEKR1 | 0.09 | 0.09 | lasso | 3 | 0.09 | 1.7e-13 | -5.2 | 5.2 | 2.5e-07 | -0.42 | 1.00 | 0.00 | FALSE |
3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | LEKR1 | 0.10 | 0.14 | lasso | 6 | 0.12 | 1.8e-10 | -5.2 | 5.3 | 1.4e-07 | -0.42 | 1.00 | 0.00 | FALSE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LEKR1 | 0.13 | 0.16 | lasso | 5 | 0.15 | 3.6e-30 | -5.3 | 5.4 | 6.8e-08 | -0.42 | 1.00 | 0.00 | FALSE |
5 | The Cancer Genome Atlas | Colon Adenocarcinoma | LEKR1 | 0.16 | 0.12 | lasso | 2 | 0.09 | 5.2e-06 | -5.3 | 5.3 | 1.1e-07 | -0.41 | 0.85 | 0.09 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC100287227 | 0.09 | 0.02 | enet | 8 | 0.02 | 1.3e-03 | 1.9 | 8.2 | 2.7e-16 | -0.57 | 0.01 | 0.54 | TRUE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | LEKR1 | 0.09 | 0.12 | lasso | 1 | 0.11 | 1.2e-12 | -5.3 | 5.3 | 1.0e-07 | -0.42 | 1.00 | 0.00 | FALSE |
8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LEKR1 | 0.23 | 0.27 | lasso | 2 | 0.26 | 1.7e-17 | -5.2 | 5.2 | 1.7e-07 | -0.43 | 1.00 | 0.00 | FALSE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LEKR1 | 0.14 | 0.15 | lasso | 1 | 0.15 | 9.8e-07 | -5.3 | 5.3 | 1.0e-07 | -0.42 | 0.40 | 0.40 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LEKR1 | 0.20 | 0.19 | lasso | 5 | 0.19 | 2.6e-19 | -5.3 | 5.1 | 3.0e-07 | -0.41 | 1.00 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LOC100287227 | 0.07 | 0.01 | blup | 47 | 0.02 | 9.8e-03 | -9.5 | 9.2 | 4.4e-20 | -0.71 | 0.02 | 0.25 | TRUE |
12 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LEKR1 | 0.12 | 0.03 | blup | 114 | 0.03 | 2.5e-02 | -3.5 | 5.7 | 1.1e-08 | -0.44 | 0.02 | 0.54 | FALSE |
13 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | LEKR1 | 0.21 | 0.14 | lasso | 4 | 0.10 | 8.6e-04 | -5.3 | 5.3 | 1.0e-07 | -0.42 | 0.08 | 0.20 | FALSE |