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chr6:35,080,558-36,897,763

Best TWAS P=6.44e-20 · Best GWAS P=1.97e-19 conditioned to 1.32e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MAPK13	0.13	0.09	lasso	5	0.08	3.0e-10	7.9	8.3	8.5e-17	-0.37	0.94	0.06	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SRPK1	0.08	0.06	lasso	4	0.06	1.6e-07	5.1	5.5	3.8e-08	-0.14	0.99	0.00	FALSE
3	GTEx	Brain Caudate basal ganglia	SRPK1	0.20	0.08	lasso	5	0.10	7.4e-04	5.8	5.8	8.6e-09	-0.13	0.33	0.04	FALSE
4	GTEx	Brain Cortex	MAPK13	0.22	0.03	lasso	4	0.05	1.9e-02	7.9	6.1	1.3e-09	-0.13	0.06	0.06	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	BRPF3	0.24	0.01	enet	26	0.00	4.2e-01	-6.2	6.5	6.0e-11	-0.48	0.06	0.12	FALSE
6	GTEx	Cells Transformed fibroblasts	MAPK13	0.12	0.05	enet	20	0.05	7.5e-05	-6.1	7.5	5.7e-14	-0.50	0.71	0.12	FALSE
7	GTEx	Colon Transverse	MAPK13	0.19	0.02	enet	17	0.08	8.1e-05	-6.2	-8.2	3.2e-16	0.47	0.19	0.40	FALSE
8	GTEx	Esophagus Mucosa	MAPK13	0.34	0.29	lasso	5	0.38	2.3e-26	7.9	-9.0	2.9e-19	0.50	0.94	0.06	FALSE
9	GTEx	Ovary	MAPK13	0.23	-0.01	enet	40	0.02	8.7e-02	-5.2	-5.6	2.1e-08	0.45	0.05	0.42	FALSE
10	GTEx	Pancreas	MAPK13	0.20	0.14	lasso	5	0.16	3.4e-07	-6.2	-8.2	2.4e-16	0.55	0.60	0.26	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	MAPK13	0.20	0.05	lasso	5	0.08	2.8e-05	7.9	-9.1	6.4e-20	0.59	0.06	0.93	TRUE
12	GTEx	Skin Sun Exposed Lower leg	MAPK13	0.23	0.20	enet	7	0.23	4.8e-19	7.9	-8.9	7.7e-19	0.47	0.95	0.05	FALSE
13	GTEx	Testis	SRPK1	0.12	0.06	lasso	12	0.09	9.4e-05	5.5	-7.1	1.5e-12	0.20	0.59	0.07	FALSE
14	GTEx	Testis	MAPK13	0.16	0.16	lasso	2	0.16	1.1e-07	7.4	-8.4	3.6e-17	0.49	0.80	0.07	FALSE
15	NTR	Blood	SRPK1	0.03	0.02	blup	452	0.02	3.8e-06	5.8	5.7	1.4e-08	-0.24	1.00	0.00	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	LHFPL5	0.12	0.17	enet	9	0.17	3.4e-21	5.1	-5.3	8.7e-08	0.13	1.00	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	RP1-179N16.6	0.37	0.38	enet	15	0.42	1.2e-58	7.4	6.3	3.9e-10	-0.36	1.00	0.00	FALSE
18	YFS	Blood	MAPK14	0.12	0.10	enet	25	0.12	1.6e-37	-6.2	-5.5	3.5e-08	0.45	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	MAPK13	0.02	0.02	lasso	2	0.01	1.1e-03	-7.2	-8.2	3.7e-16	0.61	0.04	0.71	FALSE
20	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MAPK13	0.10	0.02	blup	43	0.04	5.7e-03	7.1	-8.9	3.7e-19	0.45	0.01	0.94	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	MAPK13	0.12	0.07	blup	43	0.09	8.5e-06	7.9	-8.3	8.2e-17	0.49	0.00	0.99	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	SRPK1	0.04	0.03	blup	55	0.02	1.6e-02	6.5	-5.8	6.3e-09	0.16	0.02	0.82	FALSE
23	The Cancer Genome Atlas	Esophageal Carcinoma	MAPK13	0.14	0.12	lasso	5	0.10	4.2e-04	7.1	-6.8	1.5e-11	0.26	0.02	0.69	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MAPK13	0.04	0.05	enet	3	0.04	2.1e-05	7.9	-8.0	1.9e-15	0.32	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRPK1	0.03	0.02	blup	57	0.01	7.4e-03	5.8	-5.3	1.3e-07	0.15	0.04	0.81	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	MAPK13	0.02	0.02	enet	7	0.01	9.7e-03	7.9	-8.4	4.2e-17	0.38	0.00	0.95	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MAPK13	0.06	0.02	enet	8	0.02	2.1e-03	7.9	-7.2	7.2e-13	0.29	0.00	0.99	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	MAPK13	0.07	0.08	lasso	2	0.06	3.1e-05	7.3	-7.3	2.7e-13	0.37	0.04	0.95	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	MAPK13	0.07	0.06	lasso	6	0.06	1.5e-06	7.9	-9.0	2.6e-19	0.46	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	SRPK1	0.05	0.04	blup	57	0.04	5.0e-05	6.3	-7.0	2.1e-12	0.23	0.02	0.97	TRUE