TWAS hub - BRPF3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.244	0.0860	0.0027	0.012	NA	-0.003	NA	-0.006	0.12	NA	0.420	NA	0.550
2	GTEx	Nerve Tibial	0.164	0.0567	0.0024	-0.001	NA	0.013	NA	0.016	0.35	NA	0.038	NA	0.026

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Loud music exposure frequency	5.4	5.9	10.7	-1.0	3.3
Ever had bowel cancer screening	4.6	5.3	10.7	-3.3	0.0
Ever had hysterectomy (womb removed)	4.4	5.0	6.2	2.5	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	5.0	6.5	-1.9	2.5
Current tobacco smoking	3.6	5.9	7.6	-2.1	2.8
Medication: Omeprazole	3.6	4.3	8.2	-2.9	-0.7
Unable to work because of sickness or disability	3.6	4.7	8.9	-3.0	0.6
Medication: Omeprazole (e.g. Zanprol)	3.6	4.4	8.0	-2.8	-0.9
Had other major operations	3.5	4.3	7.9	0.8	-2.8
Financial difficulties in last 2 years	3.5	4.6	5.1	-2.1	2.3
Loneliness, isolation	3.5	4.9	9.5	-3.1	0.4
Leg fat-free mass (left)	3.4	18.1	31.0	-5.6	-2.3
Leg predicted mass (left)	3.4	18.1	31.0	-5.6	-2.3
Smoking status: Current	3.4	5.3	7.1	-1.9	2.7
Whole body fat-free mass	3.3	18.6	33.6	-5.8	-1.9
Whole body water mass	3.3	19.0	34.3	-5.9	-1.9
Leg predicted mass (right)	3.3	17.7	29.9	-5.5	-2.3
Basal metabolic rate	3.3	18.5	33.9	-5.8	-1.8
Bilateral oophorectomy (both ovaries removed)	3.2	3.7	4.4	1.7	2.1
Leg fat-free mass (right)	3.2	17.3	29.4	-5.4	-2.3
Trunk fat-free mass	3.1	17.9	33.3	-5.8	-1.6
Weight	3.0	14.9	26.4	-5.1	-1.8
Trunk predicted mass	3.0	17.1	31.7	-5.6	-1.6
Long-standing illness, disability or infirmity	3.0	4.6	9.1	-3.0	0.0
Height	2.9	55.4	102.0	-10.1	-3.0
Diabetes (self-reported)	2.9	4.5	8.7	-3.0	0.5
Heart attack/myocardial infarction (self-reported)	2.9	3.8	5.7	-2.4	-1.4
Arm predicted mass (left)	2.9	14.5	26.6	-5.2	-1.6
Heart attack	2.8	3.5	5.9	-2.4	-1.1
Qualifications: A levels/AS levels or equivalent	2.8	6.2	7.7	2.8	-2.1
Diabetes diagnosed by doctor	2.8	4.7	8.9	-3.0	0.7
Arm fat-free mass (left)	2.8	14.2	26.2	-5.1	-1.4
Medication: Metformin	2.7	3.9	7.7	-2.8	0.2
Average weekly fortified wine intake	2.7	3.1	5.3	-1.0	-2.3
Arm predicted mass (right)	2.7	13.7	25.6	-5.1	-1.3
Blood Red Count	2.6	25.1	42.8	6.5	2.7
Fed-up feelings	2.6	4.7	6.3	-2.5	1.8
Arm fat-free mass (right)	2.6	13.4	24.7	-5.0	-1.4
Eye problems/disorders: None of the above	2.6	3.0	4.9	1.1	2.2
Mouth/teeth dental problems: Loose teeth	2.6	3.1	3.7	-1.6	-1.9
Cholesterol lowering medication	2.6	3.8	7.7	-2.8	0.1
Alcohol intake versus 10 years previously	2.5	3.7	4.0	-2.0	1.9
Breast cancer (self-reported)	2.5	3.0	4.0	-2.0	-1.4
Average weekly champagne plus white wine intake	2.5	3.5	6.3	-0.8	-2.5
Medication: Lisinopril	2.5	3.2	3.8	-1.9	-1.6
Risk taking	2.5	3.7	7.4	-2.7	0.1
Diverticular disease/diverticulitis (self-reported)	2.4	2.8	5.6	2.4	0.3
Waist circumference	2.4	8.9	16.7	-4.1	-1.0
Medication for pain relief, constipation, heartburn	2.4	4.2	7.9	2.8	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	3.1	-1.8	1.6
Financial situation satisfaction	2.4	3.0	6.0	0.1	2.4
Sitting height	2.3	16.4	26.6	-5.2	-2.5
Pulse wave reflection index	2.3	2.8	3.5	1.9	1.5
Age started oral contraceptive pill	2.3	2.9	3.8	2.0	-1.4
Fasting Glucose	2.2	2.6	4.9	2.2	-0.5
Falls in the last year	2.2	3.0	5.6	-2.4	0.7
Alcohol drinker status: Never	2.2	2.6	3.0	1.7	1.5
Basal cell carcinoma (self-reported)	2.2	2.7	5.3	-2.3	-0.1
Townsend deprivation index at recruitment	2.1	3.0	5.4	-2.3	0.7
Serious illness, injury or assault to yourself	2.1	2.5	4.6	-2.1	0.6
Prospective memory result	2.1	2.5	5.0	0.3	-2.2
Glaucoma (self-reported)	2.1	2.5	3.8	-2.0	-1.1
Commuting to job workplace: Walk	2.1	2.3	3.2	-1.2	-1.8
Medication: Aspirin	2.1	2.8	5.1	-2.3	-0.6
Standing height	2.0	20.2	37.5	-6.1	-1.7
Birth weight	2.0	4.4	8.6	-2.9	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	3.9	1.2	2.0
Number of full sisters	2.0	2.4	4.7	-2.2	0.3
Comparative body size at age 10	1.9	5.3	10.5	-0.1	-3.2
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.3	2.4	1.6	-1.5
Medication: Aspirin	1.9	2.5	4.7	-2.2	-0.5
Friendships satisfaction	1.9	2.3	4.7	-0.2	2.2
Frequency of depressed mood in last 2 weeks	1.8	2.5	3.9	-1.1	2.0
Trunk fat mass	1.8	7.7	14.1	-3.8	-1.1
Medication: Simvastatin	1.8	2.6	5.1	-2.2	-0.4
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	4.6	1.0	-2.1
Shortness of breath walking on level ground	1.8	2.1	4.2	-2.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	3.3	-0.8	-1.8
Arm fat mass (right)	1.7	7.0	11.8	-3.4	-1.5
Heel T-Score	1.6	12.9	25.7	5.1	-0.4
Hearing difficulty/problems: Yes	1.6	2.5	4.2	-2.0	0.9
Qualifications: None of the above	1.6	3.4	4.9	-1.4	2.2
Whole body fat mass	1.6	6.7	12.2	-3.5	-1.1
Qualifications: nursing, teaching	1.6	2.5	4.9	0.4	-2.2
Number of operations (self-reported)	1.6	2.3	4.1	0.7	-2.0
Average weekly spirits intake	1.5	1.8	3.5	-1.9	0.3
Chronic bronchitis/emphysema (father)	1.5	1.7	3.0	-1.7	-0.7
Hip circumference	1.5	6.5	8.8	-3.0	-2.1
Neck or shoulder pain in last month	1.5	2.2	3.6	-0.8	-1.9
Leg fat mass (right)	1.5	6.0	11.4	-3.4	-0.8
Chest pain or discomfort	1.5	2.1	2.5	1.6	-1.3
Pack years adult smoking proportion	1.4	2.2	3.3	-1.8	1.0
Medication: Levothyroxine sodium	1.4	2.3	4.2	2.0	0.7
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.3	-0.0	1.8
Smoking Status	1.3	3.1	3.9	-1.5	2.0
High blood pressure (mother)	1.3	1.8	3.6	-0.1	-1.9
Depression (self-reported)	1.3	1.6	2.8	0.5	1.7
Breastfed as a baby	1.3	1.6	2.4	0.9	1.5
Birth weight of first child	1.3	2.3	2.9	-1.7	1.3
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.3	0.9	1.5
Comparative height size at age 10	1.3	7.1	14.2	-3.8	-0.0
Arm fat mass (left)	1.3	5.3	9.6	-3.1	-1.0
Pack years of smoking	1.3	1.9	3.1	-1.7	0.8
Leg fat mass (left)	1.3	5.3	9.8	-3.1	-0.8
Alzheimer’s Disease (including proxy)	1.2	1.7	2.9	0.7	1.7
Impedance of leg (left)	1.2	5.9	8.1	2.9	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	5.3	2.3	0.4
Pain all over the body in last month	1.2	1.3	2.4	-1.6	-0.4
Fluid intelligence score	1.2	2.4	4.0	-0.9	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	2.4	1.1	1.5
Gout (self-reported)	1.2	1.7	2.6	0.8	1.6
Average weekly red wine intake	1.2	1.7	3.3	-0.4	-1.8
Depression (Nagel 2018)	1.1	1.7	2.2	-1.1	1.5
Alzheimer’s Disease (in mother)	1.1	1.3	2.5	-0.4	1.6
Lupus	1.1	1.7	2.1	1.5	-1.1
Worrier / anxious feelings	1.1	2.0	3.8	0.5	2.0
Exposure to tobacco smoke outside home	1.1	1.4	2.7	-1.7	0.4
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.3	0.6	-1.5
Medication for hormone replacement therapy	1.0	1.1	2.1	1.5	0.4
Impedance of leg (right)	1.0	4.9	5.9	2.4	2.0
Relative age voice broke	1.0	1.5	2.9	1.7	-0.4
Hair/balding pattern: Pattern 3	1.0	1.5	3.0	1.7	0.3
Worry too long after embarrassment	1.0	1.7	2.8	1.7	0.8
Health satisfaction	1.0	1.3	2.4	-1.5	0.4
Suffer from ‘nerves’	1.0	1.5	3.1	0.0	1.8
Illnesses of father: High blood pressure	1.0	1.2	2.4	1.5	0.1
Heart disease (siblings)	1.0	1.2	1.4	-1.2	1.0
Breast Cancer	0.9	2.1	3.8	0.7	1.9
Body mass index (BMI)	0.9	3.7	5.9	-2.4	-1.2
Noisy workplace	0.9	1.1	1.9	-1.4	0.5
Length of working week for main job	0.9	1.0	1.7	1.3	0.5
Pulse wave peak to peak time	0.9	1.0	1.8	-1.4	-0.5
Alcohol intake frequency.	0.9	2.2	2.2	-1.5	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.6	-1.9	0.3
Back pain experienced in last month	0.9	1.4	2.8	-1.7	-0.1
Depressed Affect (Nagel 2018)	0.8	1.8	3.4	-1.9	0.4
Intelligence (Savage-Jansen 2018)	0.8	2.5	4.4	-0.7	-2.1
Rheumatoid Arthritis	0.8	1.1	2.0	0.4	-1.4
Systolic Blood Pressure	0.8	4.0	4.1	2.0	1.9
Number of treatments/medications taken	0.8	1.4	2.9	-1.7	-0.0
Supplements: Zinc	0.8	0.8	1.4	-0.5	-1.2
Had menopause	0.8	1.0	1.7	0.6	1.3
Headache pain in last month	0.8	1.4	2.2	-1.5	0.7
Migraine (self-reported)	0.8	1.0	1.0	-1.0	-1.0
Heart disease (mother)	0.8	1.0	1.5	-0.7	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.1	-0.9	1.1
Overall health rating	0.8	1.8	3.0	-1.7	-0.7
Number of self-reported non-cancer illnesses	0.8	1.4	2.3	-1.5	-0.6
Wears glasses or contact lenses	0.8	0.9	0.9	-0.9	-0.9
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.0	-1.4	0.3
Major Depression (MDD)	0.7	0.8	1.2	-0.7	1.1
Triglycerides	0.7	1.1	1.2	-1.0	-1.1
Waist Hip Ratio (WHR)	0.7	3.2	6.1	-2.5	0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.4	1.8	-1.3	1.0
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	1.8	-1.3	0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.5	-0.0	1.2
Diabetes (father)	0.7	0.9	1.6	-0.4	-1.3
Trunk fat percentage	0.7	2.8	4.8	-2.2	-0.9
Arm fat percentage (right)	0.7	2.7	4.5	-2.1	-0.9
Time employed in main current job	0.7	0.8	1.3	1.2	0.5
Number of live births	0.7	1.0	1.5	-1.2	-0.7
Hair/balding pattern: Pattern 4	0.7	1.7	3.1	-1.8	-0.6
Peak expiratory flow (PEF)	0.7	1.7	2.8	1.7	-0.8
Osteoporosis (self-reported)	0.7	0.8	1.5	-0.3	-1.2
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.5	-0.5	1.2
Irritability	0.7	1.2	1.7	-0.9	1.3
Myopia	0.7	1.1	2.1	-1.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	1.1	-0.8	-1.0
Impedance of whole body	0.7	3.7	6.1	2.5	1.2
Ovarian Cancer	0.6	0.8	1.5	-0.1	-1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.6	0.9	-1.0	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.5	2.8	1.7	-0.4
Hearing difficulty/problems with background noise	0.6	0.9	1.3	-1.1	-0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	0.9	1.0	0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	1.3	-0.1
Medication: Ramipril	0.6	0.8	0.9	-0.9	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.7	-0.6	1.3
Asthma	0.6	1.1	1.3	1.1	-1.0
Lung cancer (father)	0.6	0.7	1.3	-1.1	-0.3
Illnesses of mother	0.6	0.7	1.4	0.2	1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.5	-0.2	-1.2
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.2	-1.1	0.3
Number of full brothers	0.6	0.7	1.3	-1.1	0.3
Arm fat percentage (left)	0.6	2.2	4.0	-2.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.7	0.4	-1.3
Asthma (self-reported)	0.6	1.2	1.4	1.2	-1.0
Medication: Gliclazide	0.6	0.6	1.0	-1.0	0.5
Illnesses of father: None of the above (group 1)	0.6	0.7	1.4	-0.3	1.2
Hearing aid user	0.6	0.7	1.1	-1.0	-0.5
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	-0.1	-1.1
Medication: Atorvastatin	0.6	0.7	1.4	0.2	1.2
Pain experienced in last month	0.6	1.0	1.7	1.3	0.5
Schizophrenia vs Biploar Disorder	0.5	0.7	0.8	-0.7	-0.9
Worry (Nagel 2018)	0.5	1.1	1.3	1.1	1.0
Ulcerative Colitis (UC)	0.5	0.9	1.0	1.0	-0.9
Age at First Birth	0.5	0.7	0.9	0.7	-0.9
Neuroticism (2016)	0.5	0.7	1.0	0.7	1.0
Lung FVC	0.5	2.6	5.2	2.3	0.2
Maternal smoking around birth	0.5	0.7	0.8	-0.9	-0.8
Number of incorrect matches in round	0.5	0.9	1.6	1.3	-0.4
Allergy	0.5	1.1	1.4	-0.8	1.2
Happiness	0.5	0.6	1.3	0.1	1.1
Medication: Lansoprazole	0.5	0.6	1.0	-0.4	1.0
Blood clot in the leg (DVT)	0.5	0.6	0.8	-0.7	-0.9
Medication: Paracetamol	0.5	0.9	1.4	-1.2	-0.6
Body fat percentage	0.5	2.2	4.1	-2.0	-0.4
Qualifications: College or University degree	0.5	1.4	1.6	1.1	-1.3
Medication: Seretide 50 evohaler	0.5	0.5	0.5	-0.7	-0.7
Mean time to correctly identify matches	0.5	0.9	1.2	1.1	0.8
Illnesses of father: Heart disease	0.5	0.6	1.2	1.1	0.3
Mood swings	0.5	0.8	1.4	-1.2	0.5
Eye problems/disorders: Cataract	0.5	0.6	1.2	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.5	0.7	1.2
Medication: Bendroflumethiazide	0.5	0.7	1.3	-1.1	-0.3
Reaction Time	0.4	0.7	0.9	0.8	0.9
Mean Putamen Volume	0.4	0.4	0.8	-0.9	-0.3
Ulcerative Colitis	0.4	0.6	0.7	0.8	-0.7
Blood Eosinophil Count	0.4	3.3	3.8	-1.9	1.7
BMI	0.4	2.5	4.0	-1.0	-2.0
Systolic blood pressure, automated reading	0.4	1.1	2.1	1.4	0.1
Age when periods started (menarche)	0.4	0.9	1.2	1.1	0.7
Qualifications: CSEs or equivalent	0.4	0.6	0.8	-0.9	0.6
Medication: Atenolol	0.4	0.4	0.7	-0.8	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	-0.6	1.0
Neuroticism score	0.4	0.8	1.2	-1.1	0.7
Father’s age at death	0.4	0.5	0.9	-1.0	0.3
Medication: Cholesterol lowering	0.4	0.6	1.1	-1.1	-0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.3	1.1	0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	0.9	0.9	0.9
Leg fat percentage (right)	0.4	1.5	2.9	-1.7	0.2
Number of children fathered	0.4	0.4	0.7	-0.9	-0.3
Emphysema/chronic bronchitis	0.4	0.5	0.7	-0.4	0.8
Pulse rate, automated reading	0.4	1.2	1.6	-1.2	0.9
Medication for cholesterol	0.4	0.7	1.4	1.2	-0.0
Commuting to job workplace: Public transport	0.4	0.5	0.9	0.3	-1.0
Medication: Paracetamol	0.4	0.6	1.2	-1.1	-0.3
Ever smoked	0.4	0.7	0.9	-0.7	0.9
Diastolic blood pressure, automated reading	0.4	1.2	2.2	1.5	0.5
Ever depressed for a whole week	0.4	0.4	0.9	0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.6	1.3	-0.6
Bipolar Disorder (2018)	0.3	0.4	0.5	-0.7	-0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	1.3	-0.4	-1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	0.9	-0.9	-0.9
Body Mass Index (BMI) (2010)	0.3	0.4	0.6	-0.4	-0.7
HbA1C	0.3	0.4	0.7	-0.1	-0.8
Schizophrenia (2014)	0.3	0.7	1.1	-0.6	-1.1
Blood Platelet Count	0.3	3.7	7.3	-2.7	0.3
Blood White Count	0.3	2.2	4.3	-0.2	2.1
Chronotype (morning person)	0.3	0.6	1.1	1.1	0.3
Tanning	0.3	3.9	7.0	-0.9	2.6
Diabetes (mother)	0.3	0.4	0.5	-0.6	0.7
Severe depression (siblings)	0.3	0.3	0.6	0.7	-0.2
Alcohol usually taken with meals	0.3	0.5	0.8	-0.5	-0.9
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.8	0.3
Tense / ‘highly strung’	0.3	0.6	1.1	-0.0	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.3	0.8
Illnesses of siblings: Diabetes	0.3	0.3	0.5	0.5	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	0.1	0.8
Mineral and other dietary supplements	0.3	0.4	0.7	-0.8	0.2
Leg fat percentage (left)	0.3	1.1	2.1	-1.4	0.3
Average weekly beer plus cider intake	0.3	0.4	0.8	-0.9	-0.2
Supplements: Calcium	0.3	0.3	0.5	-0.7	-0.3
Neuroticism (Nagel 2018)	0.2	0.5	0.8	0.5	0.9
Schizophrenia (2018)	0.2	0.5	1.0	0.2	-1.0
Bipolar Disorder (2011)	0.2	0.2	0.3	-0.6	-0.4
Coronary Artery Disease (CAD)	0.2	0.3	0.5	-0.2	0.7
Primary Biliary Cirrhosis	0.2	0.2	0.4	-0.7	-0.2
Cardiovascular Disease	0.2	0.8	0.9	-0.8	1.0
Lung FEV1/FVC ratio	0.2	1.0	2.0	-1.4	0.2
Hair Pigment	0.2	4.8	6.3	-1.8	2.5
Sensitivity / hurt feelings	0.2	0.3	0.6	0.8	0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	0.4	0.6
Angina	0.2	0.3	0.5	-0.7	-0.3
Vitamin and mineral supplements	0.2	0.3	0.5	0.7	-0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.4	-0.3	-0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	0.1	-1.0
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.3	-0.5
Supplements: Glucosamine	0.2	0.3	0.6	0.0	-0.8
Forced vital capacity (FVC)	0.2	0.6	1.2	0.1	-1.1
Mouth/teeth dental problems	0.2	0.2	0.5	-0.0	0.7
Illnesses of siblings	0.2	0.2	0.4	0.1	0.6
Pulse rate	0.2	0.3	0.4	-0.5	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.7	0.0
Impedance of arm (left)	0.2	0.9	1.5	1.2	0.6
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.7	0.0
Medication: Amlodipine	0.2	0.3	0.4	-0.7	0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	-0.7	0.0
High blood pressure (siblings)	0.2	0.3	0.6	-0.8	-0.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	-0.7	0.2
Age at first live birth	0.2	0.3	0.4	0.4	0.6
Medication: Allopurinol	0.2	0.3	0.5	0.1	0.7
Leg pain on walking	0.2	0.2	0.4	-0.2	-0.6
Supplements: Vitamin C	0.2	0.3	0.5	0.2	-0.7
Hypertension (Self-reported)	0.2	0.5	0.9	-1.0	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.7	0.3
Miserableness	0.2	0.4	0.8	-0.2	0.9
Guilty feelings	0.2	0.3	0.6	-0.8	0.2
Mother’s age at death	0.2	0.3	0.5	-0.0	-0.7
Medication: Blood pressure	0.2	0.4	0.9	-0.9	-0.1
Commuting to job workplace: Cycle	0.2	0.3	0.3	0.6	0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.3	-0.5
HDL Cholesterol	0.1	0.1	0.2	0.4	-0.1
LDL Cholesterol	0.1	0.1	0.3	0.1	0.5
Allergy or Eczema	0.1	0.4	0.5	-0.5	-0.7
Respiratory disease	0.1	0.2	0.4	0.2	-0.6
Neuroticism	0.1	0.2	0.3	-0.2	-0.5
Medication: Co-codamol	0.1	0.1	0.1	-0.3	0.3
High blood pressure	0.1	0.3	0.4	-0.6	0.5
Multivitamins +/- minerals	0.1	0.1	0.2	0.4	0.1
Nervous feelings	0.1	0.2	0.4	0.0	0.6
Impedance of arm (right)	0.1	0.7	1.3	1.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.8	0.1	-0.9
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.0	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.3	0.4
Medication: Blood pressure	0.1	0.2	0.4	-0.6	0.3
Medication: Ibuprofen	0.1	0.1	0.2	-0.3	0.5
Had major operations	0.1	0.1	0.2	-0.5	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.0	0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.1	0.3
Knee pain experienced in last month	0.1	0.2	0.3	-0.5	-0.3
Smoking status: Previous	0.1	0.2	0.3	0.3	-0.6
Ever taken oral contraceptive pill	0.1	0.2	0.3	0.5	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.2	0.5
High cholesterol (Self-reported)	0.1	0.3	0.5	-0.0	0.7
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.4	0.0
Alzheimer’s Disease (in father)	0.0	0.1	0.1	0.1	-0.3
Crohns Disease (2017)	0.0	0.0	0.1	-0.1	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	-0.1
Hypothyroidism (self reported)	0.0	0.1	0.1	0.3	0.3
Hand grip strength (left)	0.0	0.1	0.1	-0.3	-0.2
Relative age of first facial hair	0.0	0.1	0.1	-0.3	0.3
Hand grip strength (right)	0.0	0.1	0.2	0.4	0.3
Taking other prescription medications	0.0	0.0	0.0	-0.1	-0.2
Past tobacco smoking	0.0	0.1	0.1	0.1	-0.3
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	0.2	-0.4
Forced vital capacity (FVC), Best measure	0.0	0.0	0.1	0.1	-0.3
Angina (self-reported)	0.0	0.1	0.1	-0.3	-0.1
Age at last live birth	0.0	0.0	0.1	-0.3	-0.0
Family relationship satisfaction	0.0	0.0	0.1	-0.3	-0.1
Fractured/broken bones in last 5 years	0.0	0.0	0.0	0.2	0.1

Hub : Genes

BRPF3

Models

Trait associations