Hub : Genes

MAPK14

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0764 0.0276 0.00066 0.059 0.023 0.045 0.044 0.050 4.5e-08 4.6e-04 1.5e-06 2.4e-06 4.2e-07
2 YFS Blood 0.1183 0.0220 0.00000 0.101 0.104 0.121 0.114 0.112 2.5e-31 3.4e-32 1.7e-37 3.2e-35 1.5e-34

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.4 2.2 1.5 0.7
Bipolar Disorder or Schizophrenia 0.7 1.7 3.2 1.8 0.4
Depressed Affect (Nagel 2018) 1.8 3.7 5.8 -1.3 2.4
Depression (Nagel 2018) 0.2 0.4 0.6 -0.4 0.7
Intelligence (Savage-Jansen 2018) 1.0 3.2 6.0 -0.6 2.5
Neuroticism (Nagel 2018) 0.2 0.5 0.9 -0.2 0.9
Schizophrenia (2018) 0.3 0.6 1.2 1.1 -0.1
Schizophrenia vs Biploar Disorder 0.3 0.4 0.8 -0.1 -0.9
Worry (Nagel 2018) 0.5 1.0 1.5 1.2 -0.7
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.4 -0.2
Alzheimer’s Disease (in father) 0.3 0.3 0.6 0.3 -0.7
Alzheimer’s Disease (including proxy) 0.9 1.3 2.2 0.6 -1.5
Crohns Disease (2017) 0.6 1.4 1.9 1.4 -1.0
Irritable Bowel Disease (IBD) 0.9 2.0 3.7 1.9 -0.6
Ulcerative Colitis (UC) 1.4 2.5 4.7 2.2 -0.6
Major Depression (MDD) 0.7 0.8 1.1 -1.0 0.8
Reaction Time 3.1 6.0 9.9 1.4 -3.2
Verbal and Numeric Reasoning (VNR) 2.3 5.6 9.5 -1.3 3.1
Breast Cancer 1.0 2.4 3.7 1.9 -1.1
Ovarian Cancer 0.7 0.9 1.8 -1.3 0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.5 0.6 0.8 -0.5
Bipolar Disorder (2011) 0.8 0.7 0.9 0.8 0.9
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 0.4 0.1
Coronary Artery Disease (CAD) 1.5 1.8 3.6 1.9 -0.2
Crohns Disease (2012) 0.5 0.8 1.5 1.2 -0.4
Mean Putamen Volume 0.2 0.2 0.4 -0.2 -0.6
Fasting Glucose 0.1 0.1 0.1 0.2 -0.3
HbA1C 0.6 0.7 0.8 0.7 0.9
HDL Cholesterol 0.3 0.5 0.8 -0.9 -0.3
LDL Cholesterol 0.2 0.4 0.5 -0.7 0.5
Lupus 0.4 0.6 0.7 -0.9 -0.7
Neuroticism (2016) 0.1 0.1 0.2 -0.4 -0.3
Primary Biliary Cirrhosis 0.8 1.2 2.3 -1.5 0.3
Rheumatoid Arthritis 1.4 2.0 2.1 -1.3 1.5
Schizophrenia (2014) 0.2 0.4 0.7 0.8 0.1
Triglycerides 0.8 1.3 2.1 0.7 1.5
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 0.1 0.5
Ulcerative Colitis 0.2 0.3 0.5 0.7 0.3
Blood Eosinophil Count 0.2 1.7 3.3 1.8 0.2
Blood Platelet Count 0.9 10.3 19.7 4.4 -0.9
Blood Red Count 2.8 27.0 30.4 4.9 -5.5
Blood White Count 1.4 10.2 20.0 4.5 0.6
Heel T-Score 1.1 8.4 13.0 1.9 -3.6
BMI 0.3 1.7 2.9 -0.7 -1.7
Height 2.4 45.4 56.4 -5.9 7.5
Waist Hip Ratio (WHR) 0.5 2.4 4.6 0.4 2.1
Systolic Blood Pressure 0.1 0.3 0.5 0.7 -0.3
Smoking Status 0.3 0.8 1.1 -0.7 1.1
Allergy or Eczema 1.6 4.2 8.3 -0.3 2.9
Cardiovascular Disease 0.1 0.5 0.7 0.5 -0.8
Hypothyroidism (self reported) 0.0 0.1 0.2 0.4 -0.2
Respiratory disease 0.4 0.9 1.7 1.3 0.4
Type 2 Diabetes (T2D) (2018) 2.8 5.3 8.0 -1.6 2.8
Lung FEV1/FVC ratio 0.0 0.2 0.4 0.6 0.2
Lung FVC 0.2 0.8 1.7 1.3 0.1
Neuroticism 0.5 1.3 1.3 -1.1 1.1
Chronotype (morning person) 2.1 4.8 7.7 1.4 -2.8
Hair Pigment 0.0 0.2 0.3 -0.5 0.3
Tanning 0.0 0.2 0.4 0.1 0.6
Hand grip strength (left) 0.2 0.4 0.9 0.9 -0.0
Number of treatments/medications taken 1.7 3.0 4.8 -1.1 2.2
Average weekly spirits intake 0.8 1.1 1.6 -1.2 0.7
Sensitivity / hurt feelings 0.3 0.6 1.1 -1.1 -0.0
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.6 -0.5 0.8
Hearing difficulty/problems: Yes 1.9 2.9 3.5 -1.9 1.5
Relative age of first facial hair 0.4 0.7 1.1 0.6 -1.0
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.1 -1.0 0.9
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.1 0.2 -0.3
Ever had hysterectomy (womb removed) 2.0 2.3 2.3 1.5 -1.5
Systolic blood pressure, automated reading 0.1 0.2 0.2 -0.5 -0.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.6 0.8 -0.5
Angina 0.4 0.6 0.6 -0.8 0.8
Medication for hormone replacement therapy 0.4 0.4 0.9 0.1 -0.9
Vitamin and mineral supplements 1.6 2.2 4.2 0.4 -2.0
Supplements: Zinc 0.5 0.6 1.0 -0.3 1.0
Medication: Co-codamol 0.0 0.0 0.0 -0.0 -0.0
Medication: Metformin 3.1 4.4 4.6 -2.0 2.2
Diabetes (father) 1.1 1.4 2.6 -1.6 0.5
Diabetes (mother) 0.3 0.4 0.7 -0.2 0.8
Severe depression (siblings) 0.3 0.3 0.7 0.0 0.8
Pack years adult smoking proportion 0.4 0.6 0.9 0.9 0.5
Impedance of leg (right) 0.4 1.7 2.7 1.6 -0.9
Leg fat-free mass (left) 0.9 4.8 5.4 -2.3 2.1
Trunk fat percentage 0.7 2.9 5.9 -2.4 -0.1
Hand grip strength (right) 0.9 2.4 4.3 2.1 -0.7
Townsend deprivation index at recruitment 0.5 0.7 1.3 -0.4 1.1
Current tobacco smoking 1.2 1.9 3.9 2.0 0.0
Average weekly fortified wine intake 0.1 0.2 0.3 0.6 -0.0
Maternal smoking around birth 1.3 1.8 1.9 -1.3 1.4
Fed-up feelings 1.3 2.3 4.1 -0.7 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 1.7 -1.1 1.3
Relative age voice broke 1.6 2.4 3.7 1.0 -1.9
Taking other prescription medications 0.1 0.1 0.2 -0.4 0.1
Age when periods started (menarche) 1.2 2.9 5.7 0.2 -2.4
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 2.4 1.5 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 3.7 8.5 9.7 3.1 -2.7
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.0 0.2 -0.2
Qualifications: CSEs or equivalent 0.8 1.1 1.3 -1.1 1.0
Serious illness, injury or assault to yourself 0.7 0.8 1.5 1.2 0.3
High blood pressure 0.1 0.1 0.3 -0.1 -0.5
Hayfever, allergic rhinitis or eczema 1.3 2.9 5.8 -0.3 2.4
Multivitamins +/- minerals 1.1 1.4 2.7 -0.3 1.6
Stomach or abdominal pain in last month 0.6 0.7 1.4 0.3 -1.2
Supplements: Glucosamine 0.7 0.9 1.6 -1.3 0.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.5 0.1 -0.7
Medication: Atenolol 0.8 1.0 1.9 0.2 1.4
Medication: Levothyroxine sodium 1.6 2.7 3.1 1.8 -1.5
Sitting height 1.4 9.9 14.4 -2.3 3.8
Chronic bronchitis/emphysema (father) 1.5 1.8 1.8 -1.3 1.3
High blood pressure (mother) 0.2 0.3 0.7 -0.2 -0.8
Body mass index (BMI) 0.3 1.2 2.0 -1.4 -0.6
Impedance of leg (left) 0.3 1.3 1.6 1.2 -1.0
Leg predicted mass (left) 0.9 4.9 5.3 -2.3 2.1
Trunk fat mass 0.9 3.9 7.4 -2.7 0.6
Waist circumference 0.2 0.8 1.2 -1.1 0.6
Number of incorrect matches in round 1.0 1.6 2.6 0.8 -1.6
Past tobacco smoking 3.0 5.6 8.1 2.8 -1.7
Alcohol usually taken with meals 0.1 0.2 0.4 0.1 0.6
Nervous feelings 0.1 0.1 0.3 0.0 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 -0.3 0.7
Hearing difficulty/problems with background noise 1.4 2.3 2.6 -1.6 1.4
Hair/balding pattern: Pattern 2 0.6 0.8 1.5 -1.2 -0.2
Had menopause 0.9 1.1 1.7 0.7 -1.3
Had other major operations 1.3 1.5 2.0 1.4 -1.0
Forced vital capacity (FVC) 0.2 0.7 0.9 0.9 0.8
Heel bone mineral density (BMD) T-score, automated (right) 5.1 11.7 13.7 3.7 -3.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.5 0.4 -0.7
Qualifications: None of the above 0.4 0.9 1.6 -0.4 1.3
Financial difficulties in last 2 years 0.8 1.1 1.2 1.1 1.0
Mouth/teeth dental problems 0.6 0.9 1.4 -1.2 -0.7
Heart attack 0.2 0.3 0.4 -0.4 0.6
Allergy 1.1 2.4 4.7 0.4 -2.2
Pain all over the body in last month 0.2 0.2 0.2 0.4 0.5
Diabetes (self-reported) 4.1 6.4 7.5 -2.3 2.7
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.8 0.5 0.9
Medication: Ramipril 0.4 0.5 0.7 -0.4 -0.9
Medication: Simvastatin 1.7 2.5 4.9 -0.3 2.2
Fluid intelligence score 2.6 5.3 6.4 -2.1 2.5
Illnesses of siblings 0.8 1.2 1.5 0.9 -1.2
Neuroticism score 0.6 1.4 2.4 -0.5 1.6
Weight 0.8 3.7 5.8 -2.4 1.3
Impedance of arm (right) 0.2 0.7 1.0 -0.7 1.0
Arm fat percentage (right) 0.7 2.6 5.2 -2.3 -0.2
Trunk fat-free mass 0.8 4.5 6.3 -1.6 2.5
Hip circumference 0.4 1.7 3.2 -1.8 -0.4
Time employed in main current job 1.7 1.9 3.7 -0.3 -1.9
Alcohol intake versus 10 years previously 0.1 0.2 0.3 0.6 -0.1
Father’s age at death 0.9 1.2 1.7 -1.3 0.9
Worrier / anxious feelings 1.0 2.0 2.5 1.2 -1.6
Frequency of tiredness / lethargy in last 2 weeks 2.5 4.0 5.3 -2.3 1.7
Falls in the last year 3.0 4.1 6.5 -1.3 2.5
Hair/balding pattern: Pattern 3 0.0 0.1 0.1 0.2 0.3
Number of live births 0.4 0.6 0.8 -0.6 0.9
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.4 1.2 0.8
Pulse rate 1.3 2.2 4.3 0.3 2.1
Happiness 0.2 0.2 0.3 -0.5 0.5
Noisy workplace 0.9 1.1 1.6 0.8 1.3
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.4 0.6 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 -0.4 -0.3
Mouth/teeth dental problems: Dentures 0.4 0.7 1.3 1.1 -0.5
Asthma 0.4 0.8 0.9 1.0 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.4 0.6 0.6
Medication: Cholesterol lowering 1.8 2.9 4.1 -1.3 2.0
Depression (self-reported) 0.2 0.2 0.2 0.5 -0.4
Medication: Lansoprazole 0.2 0.3 0.4 -0.7 -0.3
Prospective memory result 0.1 0.2 0.2 -0.3 -0.5
Lung cancer (father) 0.9 1.1 2.2 1.5 -0.1
Illnesses of mother 0.1 0.2 0.3 -0.3 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 0.9 0.7 1.0
Pulse wave Arterial Stiffness index 0.7 0.8 1.6 -0.2 1.3
Impedance of arm (left) 0.2 0.8 1.1 -0.6 1.0
Arm fat mass (right) 0.7 2.9 5.7 -2.4 0.4
Trunk predicted mass 0.7 4.1 5.8 -1.6 2.4
Standing height 1.1 11.1 17.3 -2.2 4.2
Length of working week for main job 0.3 0.3 0.4 0.7 -0.4
Exposure to tobacco smoke at home 0.4 0.4 0.7 -0.8 0.4
Breastfed as a baby 0.4 0.5 0.8 -0.3 -0.9
Tense / ‘highly strung’ 0.5 0.9 1.6 1.3 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.0 1.0 -0.1
Hair/balding pattern: Pattern 4 0.6 1.4 2.0 1.4 0.9
Birth weight of first child 0.0 0.1 0.1 -0.4 0.2
Peak expiratory flow (PEF) 1.6 3.7 6.1 2.5 -1.2
Pulse wave reflection index 0.3 0.3 0.5 -0.4 -0.7
Ever highly irritable/argumentative for 2 days 0.9 1.1 1.2 1.0 -1.1
Loud music exposure frequency 0.3 0.3 0.6 0.8 0.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 0.0 0.6
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.4 0.2 1.2
Blood clot in the leg (DVT) 1.3 1.6 2.2 -1.1 1.5
Medication: Paracetamol 0.5 0.9 1.7 0.2 1.3
Headache pain in last month 0.6 1.0 1.0 -1.0 1.0
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 2.8 1.3 -1.7
Glaucoma (self-reported) 0.3 0.3 0.4 -0.5 0.6
Gout (self-reported) 1.3 1.8 2.3 1.2 -1.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.4 0.7 -0.6
Medication: Amlodipine 0.2 0.3 0.4 0.6 -0.3
Medication: Ventolin 100micrograms inhaler 0.5 0.7 0.9 -0.6 1.0
Birth weight 3.3 7.1 13.0 -1.1 3.6
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.4 -0.7 -0.3
High blood pressure (siblings) 0.3 0.4 0.7 -0.2 0.9
Forced vital capacity (FVC), Best measure 0.2 0.8 1.5 0.3 1.2
Body fat percentage 0.7 2.7 5.2 -2.3 -0.4
Leg fat percentage (right) 0.6 2.2 3.3 -1.8 -1.0
Arm fat-free mass (right) 0.4 2.3 2.7 -1.4 1.6
Exposure to tobacco smoke outside home 0.2 0.2 0.4 -0.6 0.0
Comparative body size at age 10 0.1 0.2 0.3 -0.0 0.6
Number of full brothers 0.5 0.7 1.3 -1.2 0.2
Worry too long after embarrassment 0.2 0.3 0.5 -0.7 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.4 0.4 -0.6
Wheeze or whistling in the chest in last year 0.3 0.6 1.0 1.0 -0.4
Number of children fathered 0.7 0.7 0.7 -0.9 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.4 -0.5 1.6
Age at first live birth 0.1 0.2 0.4 -0.3 -0.6
Pulse wave peak to peak time 0.4 0.5 1.0 -0.0 -1.0
Health satisfaction 0.3 0.4 0.5 0.5 -0.7
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.3 0.4
Qualifications: College or University degree 0.2 0.7 1.0 1.0 0.6
Eye problems/disorders: None of the above 0.1 0.2 0.3 -0.5 0.3
Mouth/teeth dental problems: Loose teeth 1.4 1.7 3.0 -0.6 1.7
Emphysema/chronic bronchitis 0.1 0.1 0.3 -0.5 0.0
Medication for pain relief, constipation, heartburn 2.2 3.8 6.8 0.9 -2.6
Neck or shoulder pain in last month 1.8 2.6 4.8 -0.5 2.2
Medication: Blood pressure 0.7 1.2 1.6 -1.2 0.9
Angina (self-reported) 0.3 0.4 0.4 -0.6 0.6
Migraine (self-reported) 1.3 1.6 1.9 -1.4 1.2
Medication: Ibuprofen 0.5 0.6 0.8 0.6 0.9
Medication: Allopurinol 1.6 2.1 3.1 1.1 -1.8
Medication: Omeprazole 1.5 1.7 3.0 -0.7 1.7
Medication: Seretide 50 evohaler 0.3 0.3 0.4 0.6 -0.5
Mean time to correctly identify matches 1.6 3.0 5.7 0.5 -2.4
Heart disease (mother) 1.2 1.5 3.0 -0.0 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 1.6 -1.3 0.3
Whole body fat mass 0.8 3.2 6.2 -2.5 0.4
Leg fat mass (right) 0.7 2.7 5.5 -2.3 -0.1
Arm predicted mass (right) 0.6 3.1 3.2 -1.7 1.8
Pulse rate, automated reading 1.5 4.9 9.7 -0.3 3.1
Alcohol intake frequency. 0.3 0.6 0.7 -0.9 -0.7
Comparative height size at age 10 1.0 5.5 9.6 -1.1 3.1
Number of full sisters 3.2 3.9 6.0 -2.5 1.4
Suffer from ‘nerves’ 0.0 0.1 0.1 -0.1 0.4
Overall health rating 0.1 0.2 0.3 -0.2 0.6
Chest pain or discomfort 0.9 1.3 2.4 0.5 -1.5
Had major operations 0.0 0.0 0.0 -0.1 0.1
Age at last live birth 0.2 0.3 0.6 -0.2 0.8
Family relationship satisfaction 3.2 4.0 5.1 -1.7 2.2
Leg pain on walking 0.2 0.3 0.4 -0.4 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.6 0.8 -0.5
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.2 -0.5 0.3
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 -0.1 0.0
Medication: Aspirin 3.7 4.8 7.4 -1.5 2.7
Supplements: Vitamin C 0.5 0.6 0.8 0.9 -0.7
Knee pain experienced in last month 0.1 0.2 0.3 -0.5 -0.3
Hypertension (Self-reported) 0.1 0.3 0.4 -0.3 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 -0.2 0.2
Illnesses of father: Heart disease 0.7 1.0 1.5 -1.2 0.7
Illnesses of siblings: Diabetes 0.6 0.8 1.1 -1.0 0.7
Smoking status: Previous 3.6 5.4 8.3 -2.9 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 2.6 -0.6 1.6
Whole body fat-free mass 0.9 5.0 5.9 -2.1 2.4
Leg fat-free mass (right) 0.9 4.9 5.5 -2.3 2.1
Arm fat percentage (left) 0.8 3.3 6.6 -2.6 -0.2
Average weekly red wine intake 2.1 3.1 4.0 -2.0 1.5
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 0.4 0.3
Mood swings 0.3 0.5 0.9 0.4 1.0
Loneliness, isolation 1.9 2.6 5.1 0.2 2.3
Long-standing illness, disability or infirmity 1.7 2.6 5.2 -0.2 2.3
Ever had bowel cancer screening 2.5 2.9 4.7 -1.1 2.2
Diabetes diagnosed by doctor 3.0 5.0 6.6 -1.8 2.6
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 1.6 1.3 0.3
Friendships satisfaction 0.5 0.6 0.7 -0.8 0.7
Qualifications: nursing, teaching 0.5 0.7 1.0 -1.0 0.6
Commuting to job workplace: Walk 0.2 0.2 0.4 -0.6 0.2
Eye problems/disorders: Cataract 0.0 0.0 0.0 0.1 0.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 0.8 0.9 -0.8
Medication for cholesterol 0.4 0.7 1.0 0.6 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.9 -0.5 0.9
Back pain experienced in last month 0.0 0.1 0.1 0.2 0.3
Mineral and other dietary supplements 0.9 1.2 1.3 1.1 -1.1
Breast cancer (self-reported) 0.2 0.2 0.4 0.2 -0.6
Asthma (self-reported) 0.3 0.7 1.0 1.0 -0.6
Osteoporosis (self-reported) 0.7 0.9 1.2 0.8 -1.1
Osteoarthritis (self-reported) 0.2 0.2 0.4 -0.6 -0.2
Medication: Aspirin 3.7 4.8 8.5 -1.1 2.9
Medication: Gliclazide 2.8 3.2 5.2 -1.0 2.3
Illnesses of father: None of the above (group 1) 2.0 2.5 3.8 2.0 -1.1
Smoking status: Current 1.0 1.6 3.3 1.8 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.2 2.1 0.4 1.5
Whole body water mass 0.9 5.3 6.1 -2.1 2.5
Leg predicted mass (right) 0.9 4.9 5.6 -2.4 2.1
Arm fat mass (left) 0.8 3.2 6.4 -2.5 0.2
Number of self-reported non-cancer illnesses 0.3 0.5 0.7 -0.7 0.8
Average weekly champagne plus white wine intake 0.3 0.4 0.6 0.8 0.5
Miserableness 0.6 1.1 1.4 -0.9 1.2
Guilty feelings 0.2 0.3 0.5 -0.0 0.7
Wears glasses or contact lenses 1.7 1.9 2.3 -1.2 1.5
Ever taken oral contraceptive pill 2.9 3.2 4.0 1.6 -2.0
Hearing aid user 0.4 0.5 0.7 -0.8 0.5
Mother’s age at death 0.4 0.6 0.6 -0.7 0.8
Financial situation satisfaction 0.5 0.6 0.7 0.7 -0.8
Tinnitus: Yes, now most or all of the time 0.0 0.1 0.1 -0.3 -0.0
Commuting to job workplace: Public transport 0.3 0.4 0.5 0.7 -0.5
Eye problems/disorders: Glaucoma 0.0 0.0 0.0 -0.1 -0.0
Medication: Blood pressure 0.2 0.5 0.9 0.9 0.1
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.1 0.4
Supplements: Fish oil (including cod liver oil) 1.4 1.8 1.8 -1.4 1.3
High cholesterol (Self-reported) 0.2 0.4 0.6 0.7 -0.6
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.5 0.1
Medication: Paracetamol 0.5 0.8 0.8 0.8 0.9
Medication: Lisinopril 0.3 0.4 0.9 -0.1 0.9
Medication: Atorvastatin 0.1 0.1 0.1 -0.3 0.1
Illnesses of father: High blood pressure 0.7 0.8 1.1 0.7 -1.1
Alcohol drinker status: Never 0.7 0.8 1.4 -0.4 -1.2
Ever smoked 2.2 3.9 4.4 -2.1 1.8
Basal metabolic rate 0.9 5.1 5.2 -2.3 2.2
Leg fat percentage (left) 0.8 2.8 4.1 -2.0 -1.2
Arm fat-free mass (left) 0.5 2.3 2.4 -1.5 1.6
Number of operations (self-reported) 0.5 0.7 1.3 1.2 -0.3
Average weekly beer plus cider intake 0.7 1.0 1.3 -0.8 1.1
Irritability 0.4 0.7 1.1 0.5 1.1
Risk taking 2.0 2.9 5.4 -0.7 2.3
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.0 -0.5
Fractured/broken bones in last 5 years 0.2 0.3 0.4 0.6 0.3
Age started oral contraceptive pill 1.8 2.3 2.3 1.5 -1.5
Diastolic blood pressure, automated reading 0.4 1.1 1.7 -0.7 -1.3
Ever depressed for a whole week 0.5 0.6 0.6 0.8 -0.7
Unable to work because of sickness or disability 1.7 2.3 2.4 -1.6 1.4
Commuting to job workplace: Cycle 0.0 0.0 0.1 0.0 0.3
Myopia 0.4 0.5 0.6 -0.7 0.7
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.3 0.6 -0.4
Cholesterol lowering medication 1.5 2.2 3.9 -0.8 2.0
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.2 -0.0 1.5
Pain experienced in last month 0.1 0.2 0.2 -0.4 -0.5
Supplements: Calcium 1.9 2.1 2.6 -1.6 1.2
Basal cell carcinoma (self-reported) 0.7 0.9 1.6 -0.3 1.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.5 -0.6 0.7
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 1.3 -0.9 1.1
Heart disease (siblings) 0.0 0.0 0.0 -0.1 0.2
Alcohol drinker status: Previous 0.1 0.2 0.3 -0.1 -0.6
Pack years of smoking 0.2 0.3 0.4 0.6 0.4
Impedance of whole body 0.0 0.2 0.4 0.6 -0.3
Leg fat mass (left) 0.8 3.0 6.0 -2.5 -0.2
Arm predicted mass (left) 0.7 3.7 4.3 -2.1 1.8