Hub : Genes

SRPK1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0290	3.4e-05	0.062	0.030	0.045	0.036	0.057	5.2e-08	1.1e-04	3.1e-06	3.1e-05	1.6e-07
2	GTEx	Brain Caudate basal ganglia	0.2020	0.0770	2.0e-03	0.081	NA	0.011	NA	0.102	2.5e-03	NA	1.5e-01	NA	7.4e-04
3	GTEx	Brain Cerebellar Hemisphere	0.3260	0.0910	1.7e-04	0.092	NA	0.039	NA	0.093	2.4e-03	NA	3.6e-02	NA	2.3e-03
4	GTEx	Skin Sun Exposed Lower leg	0.1360	0.0460	8.7e-04	0.004	NA	0.018	NA	0.004	1.4e-01	NA	1.2e-02	NA	1.3e-01
5	GTEx	Testis	0.1220	0.0450	1.0e-03	0.063	NA	0.072	NA	0.089	8.9e-04	NA	4.3e-04	NA	9.4e-05
6	METSIM	Adipose	0.0590	0.0209	5.3e-05	0.012	0.043	0.010	0.041	0.018	5.5e-03	3.9e-07	9.0e-03	6.8e-07	7.9e-04
7	NTR	Blood	0.0269	0.0087	2.6e-06	0.020	0.016	0.009	0.016	0.016	3.9e-07	3.8e-06	5.0e-04	5.9e-06	4.2e-06
8	YFS	Blood	0.0605	0.0144	2.2e-16	0.049	0.058	0.051	0.058	0.053	1.2e-15	2.8e-18	3.1e-16	2.0e-18	6.3e-17
9	TCGA	Colon Adenocarcinoma	0.0370	0.0270	5.3e-03	0.026	0.023	0.012	NA	0.020	1.2e-02	1.6e-02	6.3e-02	NA	2.4e-02
10	TCGA	Brain Lower Grade Glioma	0.0271	0.0210	1.7e-03	0.016	0.015	0.013	NA	0.010	5.8e-03	7.4e-03	1.2e-02	NA	2.4e-02
11	TCGA	Rectum Adenocarcinoma	0.1110	0.0780	8.9e-03	0.052	0.062	0.067	NA	0.038	2.4e-02	1.5e-02	1.2e-02	NA	4.6e-02
12	TCGA	Thyroid Carcinoma	0.0480	0.0320	1.7e-04	0.042	0.043	0.028	NA	0.036	6.2e-05	5.0e-05	8.2e-04	NA	1.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.8	2.8	5.6	-1.8	-1.7	-2.0	1.3	2.0	-0.5	-2.4	-1.3	1.7	1.9	1.6	1.4
Bipolar Disorder or Schizophrenia	2.2	5.3	7.6	-2.3	-2.5	-2.6	0.5	2.3	-2.4	-2.7	-2.2	2.5	2.8	2.1	1.9
Depressed Affect (Nagel 2018)	0.3	0.7	2.0	-0.8	-1.0	-0.3	1.1	1.1	1.4	-0.5	-0.1	0.9	0.7	0.4	0.9
Depression (Nagel 2018)	0.3	0.4	2.4	-0.5	-0.1	-0.1	1.3	-0.5	1.5	0.3	0.1	0.3	0.3	0.3	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.6	-1.0	-0.7	-0.5	1.2	0.1	-0.5	-0.3	0.3	0.7	1.1	1.3	0.8
Neuroticism (Nagel 2018)	0.4	0.9	2.5	-0.7	-1.5	-0.6	1.0	-0.2	1.6	0.1	-0.8	1.1	1.1	1.1	0.7
Schizophrenia (2018)	1.4	2.8	6.9	-1.6	-1.8	-1.6	-0.5	1.4	-2.6	-1.5	-1.7	1.8	2.0	1.4	1.4
Schizophrenia vs Biploar Disorder	0.2	0.2	0.8	0.9	-0.0	0.7	0.2	-0.3	-0.5	0.4	-0.6	-0.2	-0.4	-0.1	-0.0
Worry (Nagel 2018)	0.3	0.6	1.8	0.1	-0.9	-0.1	0.1	-1.4	0.7	0.8	-1.2	0.5	0.7	0.9	-0.2
Alzheimer’s Disease (in mother)	1.4	1.7	3.3	-1.5	-1.8	-1.0	-0.3	0.2	-1.6	-0.0	-1.6	1.4	1.6	1.6	1.3
Alzheimer’s Disease (in father)	0.2	0.2	1.3	-0.1	-0.1	0.4	-1.1	0.2	-0.5	0.6	-0.4	-0.2	-0.4	-0.2	0.2
Alzheimer’s Disease (including proxy)	0.3	0.5	1.5	-0.0	-0.1	0.6	-1.2	-0.7	-1.2	1.0	-0.5	-0.4	-0.5	-0.2	-0.3
Crohns Disease (2017)	1.1	2.5	4.1	-1.8	-1.4	-1.9	0.3	1.4	-0.4	-1.8	-2.0	1.8	1.6	1.3	2.0
Irritable Bowel Disease (IBD)	3.4	8.2	12.8	-3.3	-3.0	-2.8	1.0	2.2	-1.7	-2.7	-3.6	3.4	3.4	2.7	3.3
Ulcerative Colitis (UC)	3.7	7.0	11.4	-3.1	-3.3	-2.3	0.6	1.6	-1.6	-2.3	-3.4	3.2	3.3	2.7	2.7
Major Depression (MDD)	0.9	1.1	2.8	1.1	1.7	0.9	0.6	-0.9	0.9	-0.0	0.8	-1.2	-1.2	-0.7	-1.5
Reaction Time	0.1	0.2	1.1	-0.3	0.1	0.1	-1.0	-0.4	0.1	0.1	-0.7	0.2	-0.1	-0.5	-0.2
Verbal and Numeric Reasoning (VNR)	1.5	3.5	8.5	1.7	2.1	2.4	0.5	-1.7	0.9	2.2	2.9	-2.1	-1.7	-1.4	-1.8
Breast Cancer	0.7	1.7	5.8	-0.8	-1.2	-0.7	2.4	-0.5	-0.1	-1.1	-0.7	1.3	1.9	2.0	0.6
Ovarian Cancer	0.1	0.2	0.6	-0.2	-0.6	0.1	-0.2	-0.5	-0.3	0.5	-0.1	0.5	0.1	0.4	0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.7	2.4	5.8	2.0	1.2	1.3	-1.9	-1.7	1.2	1.6	0.1	-1.8	-1.1	-1.0	-2.4
Bipolar Disorder (2011)	1.2	1.2	2.4	-1.0	-1.5	-1.6	0.3	0.7	0.5	-1.4	-0.6	1.1	1.2	1.2	1.1
Body Mass Index (BMI) (2010)	0.5	0.6	1.6	-0.3	-0.2	-1.1	1.2	-1.2	1.2	-0.6	1.1	0.1	0.0	0.0	0.5
Coronary Artery Disease (CAD)	0.5	0.6	1.7	-1.1	-0.7	-1.3	-0.0	-0.1	0.7	-0.5	-0.6	0.8	1.1	1.2	0.1
Crohns Disease (2012)	0.3	0.5	1.6	-0.5	-0.3	-0.8	0.6	0.5	-0.6	-0.9	-1.3	0.6	0.7	0.6	0.8
Mean Putamen Volume	2.7	3.1	7.6	-1.7	-1.4	-1.3	0.4	1.6	-2.8	-1.9	-1.6	2.0	1.7	2.1	1.7
Fasting Glucose	3.2	3.8	8.9	2.2	1.8	1.8	0.6	-2.4	3.0	0.6	2.0	-1.9	-2.4	-1.4	-1.8
HbA1C	1.7	1.9	5.3	-1.4	-1.3	-1.1	0.7	2.3	-0.9	-0.6	-1.8	1.4	1.4	1.0	1.7
HDL Cholesterol	0.3	0.5	3.8	0.1	-0.6	-0.2	-1.9	-0.3	0.4	0.5	0.2	0.1	0.5	0.8	0.0
LDL Cholesterol	0.1	0.2	0.6	0.2	-0.7	-0.4	-0.8	-0.2	0.1	0.1	0.0	0.1	0.4	0.6	0.2
Lupus	0.2	0.3	2.4	0.2	0.1	-0.6	-0.3	-0.4	0.6	-1.6	-0.5	-0.1	-0.2	0.2	-0.2
Neuroticism (2016)	0.6	0.8	2.4	1.3	0.7	1.3	0.2	-0.4	1.6	1.0	-0.0	-0.5	-1.0	-0.7	-0.6
Primary Biliary Cirrhosis	1.4	2.0	5.7	-1.5	-1.3	-0.9	-0.4	1.6	-0.8	-2.4	-1.4	1.4	1.3	1.4	1.6
Rheumatoid Arthritis	0.6	0.8	3.7	-0.4	-0.6	-0.7	1.9	0.8	0.2	-1.9	0.1	0.3	0.1	0.3	0.7
Schizophrenia (2014)	1.8	4.0	9.9	-1.4	-2.0	-2.1	-0.4	2.0	-3.1	-1.9	-2.1	2.0	2.2	1.9	1.8
Triglycerides	0.6	0.9	6.9	0.6	0.6	0.8	2.6	0.2	0.0	-0.8	0.9	-0.7	-0.5	-0.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.5	-0.8	-0.2	-0.4	0.6	0.6	0.4	-0.4	-0.1	0.1	0.3	-0.2
Ulcerative Colitis	2.7	3.9	6.1	-2.4	-2.3	-1.6	0.8	1.5	-1.3	-1.8	-1.9	2.4	2.5	2.0	2.4
Blood Eosinophil Count	5.5	42.2	74.8	-6.2	-8.6	-6.1	-0.8	5.0	-1.6	-4.2	-8.5	7.7	8.3	7.9	6.9
Blood Platelet Count	0.3	3.4	18.2	-0.0	-1.5	-0.3	-3.4	-0.3	1.5	1.6	-4.3	1.0	1.5	0.6	0.3
Blood Red Count	3.0	29.2	50.1	5.5	5.8	4.8	-1.5	-7.1	5.0	5.7	5.0	-5.8	-5.3	-4.2	-7.0
Blood White Count	0.2	1.5	4.9	-1.1	-0.4	-2.2	0.6	-1.8	0.4	0.1	-0.9	1.1	1.7	1.6	0.4
Heel T-Score	0.9	7.1	20.9	1.8	3.2	3.0	0.3	-3.1	1.2	4.6	1.2	-2.8	-2.9	-2.6	-2.5
BMI	0.4	2.5	19.6	-0.8	0.5	-0.2	4.4	0.6	1.4	-2.1	1.6	0.2	0.0	0.6	0.5
Height	1.3	25.9	136.9	-2.0	2.3	-0.7	11.7	5.6	-9.8	-4.4	1.9	0.4	-0.6	-1.2	3.2
Waist Hip Ratio (WHR)	1.7	7.7	13.5	-2.3	-2.1	-3.5	0.8	2.4	-2.0	-2.1	-3.5	3.2	3.5	3.7	2.7
Systolic Blood Pressure	0.9	4.7	35.5	-0.6	-1.8	-1.8	-6.0	0.9	2.8	0.4	-1.7	1.4	0.8	0.1	1.0
Smoking Status	0.1	0.2	1.2	0.1	0.5	0.4	0.5	1.1	0.2	0.0	0.3	-0.4	-0.3	-0.0	-0.2
Allergy or Eczema	0.4	0.9	2.5	-0.7	-0.8	-1.3	0.2	0.9	0.9	-1.6	-1.0	0.7	1.1	1.2	0.5
Cardiovascular Disease	0.3	0.9	2.3	-0.8	-0.9	-1.0	-0.4	1.1	0.5	-1.0	-1.5	1.1	1.1	1.1	0.3
Hypothyroidism (self reported)	1.0	2.3	18.9	-0.0	-1.1	-0.6	4.3	-0.2	2.1	-0.8	1.3	0.1	0.4	0.2	0.1
Respiratory disease	0.3	0.7	3.0	0.5	0.0	0.3	-1.7	-0.8	1.2	-1.6	0.3	-0.3	-0.1	-0.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.5	-1.4	-0.2	-1.6	0.0	0.9	-0.0	0.6	-0.3	0.9	1.0	1.3	0.7
Lung FEV1/FVC ratio	0.6	2.9	18.6	-0.7	1.6	1.0	4.3	-0.3	-3.0	1.3	0.7	0.0	-0.3	-0.8	0.4
Lung FVC	2.4	12.4	26.5	2.9	4.6	3.5	-3.0	-2.7	-0.1	5.1	3.2	-3.5	-3.8	-4.3	-3.1
Neuroticism	0.1	0.3	1.3	-0.3	-1.0	0.1	1.1	0.1	0.6	-0.2	-0.7	0.6	0.4	0.2	0.5
Chronotype (morning person)	0.2	0.4	2.2	0.3	0.6	0.2	-0.2	-1.5	-0.2	0.5	-0.9	-0.6	-0.4	-0.0	-1.0
Hair Pigment	0.1	2.5	6.8	-1.5	-1.5	-1.7	2.6	1.8	-1.1	-0.7	-1.9	1.7	0.8	0.9	1.8
Tanning	0.1	1.3	3.2	0.8	1.5	1.5	0.2	0.2	-0.4	1.8	-0.4	-1.2	-1.2	-1.5	-1.3
Hand grip strength (left)	0.8	2.0	6.9	0.6	2.0	1.4	2.6	0.1	-1.8	0.7	0.8	-1.2	-1.1	-1.7	-0.8
Number of treatments/medications taken	1.1	2.1	3.7	-1.2	-1.7	-1.9	-1.0	1.2	0.2	-1.7	-1.0	1.8	1.8	1.5	1.4
Average weekly spirits intake	0.9	1.2	4.4	0.7	1.0	0.9	2.1	0.6	1.8	-0.1	0.9	-0.5	-1.2	-1.0	0.0
Sensitivity / hurt feelings	0.7	1.1	4.7	-0.7	-1.4	-0.3	2.2	-0.1	-0.5	-0.2	-0.9	1.1	1.2	1.4	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-0.4	0.4	0.3	0.7	-0.5	0.9	0.9	0.7	-0.1	-0.2	-0.4	-0.3
Hearing difficulty/problems: Yes	0.3	0.5	2.2	-0.1	-0.5	-0.0	1.5	0.8	1.1	1.0	0.5	-0.1	-0.2	0.2	0.2
Relative age of first facial hair	0.3	0.6	3.5	0.3	0.4	1.0	-1.9	-0.3	0.3	0.9	0.1	-0.6	-0.5	-0.5	-0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	-0.4	-0.3	-0.8	0.4	0.4	-0.9	-0.7	0.1	0.4	0.7	0.3	-0.1
Ever used hormone-replacement therapy (HRT)	2.9	3.7	7.0	-2.6	-2.0	-2.2	-0.7	1.4	-1.4	-1.9	-1.4	2.4	2.1	1.8	2.2
Ever had hysterectomy (womb removed)	3.7	4.1	7.5	-2.5	-2.1	-2.7	-2.5	0.1	-1.3	-1.4	-2.1	2.1	2.4	2.1	1.4
Systolic blood pressure, automated reading	0.9	2.5	13.4	-0.4	-1.7	-1.3	-3.7	0.3	2.9	-0.2	-0.5	1.2	0.8	0.5	1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.0	-0.5	-0.0	-0.2	-1.0	0.5	-0.5	0.1	-0.6	0.2	-0.0	-0.1	-0.2
Angina	0.4	0.5	2.4	-0.7	-0.8	-1.6	0.1	0.6	0.3	-0.3	0.6	0.8	0.7	0.5	0.8
Medication for hormone replacement therapy	2.2	2.5	7.6	-1.6	-1.2	-1.2	0.2	0.3	-2.7	-2.0	-1.5	1.8	1.7	1.5	1.6
Vitamin and mineral supplements	0.3	0.4	1.7	-1.3	-0.4	-0.6	-0.7	0.5	-0.6	-0.4	-0.3	0.7	0.7	0.7	0.2
Supplements: Zinc	2.6	2.8	5.7	1.6	1.6	2.4	0.9	-0.7	0.6	1.8	1.5	-2.1	-2.0	-1.8	-2.0
Medication: Co-codamol	1.7	2.0	4.4	1.8	2.1	1.3	0.3	-1.2	0.4	0.5	1.5	-1.6	-1.7	-1.5	-1.7
Medication: Metformin	0.3	0.4	1.4	-0.5	0.7	-0.9	0.4	0.4	-1.2	0.0	-0.0	0.3	0.5	0.9	-0.1
Diabetes (father)	1.3	1.6	3.6	-1.5	-1.9	-0.8	0.3	1.4	-0.4	-1.4	-0.5	1.6	1.2	0.8	1.9
Diabetes (mother)	0.2	0.3	0.8	0.5	0.6	0.1	0.5	-0.8	-0.6	0.4	0.2	-0.5	-0.1	0.4	-0.9
Severe depression (siblings)	0.2	0.2	0.7	0.6	0.5	0.4	0.6	0.6	0.0	0.9	0.6	-0.5	-0.3	-0.1	-0.1
Pack years adult smoking proportion	1.0	1.5	5.5	2.3	1.0	1.0	0.0	0.1	1.5	0.9	0.1	-1.5	-1.6	-1.0	-1.2
Impedance of leg (right)	0.9	4.4	10.9	-2.0	-3.3	-2.5	-0.8	0.8	-0.3	-0.7	-2.7	2.4	2.7	2.4	1.8
Leg fat-free mass (left)	1.4	7.5	43.6	0.2	3.4	1.1	6.6	1.3	-3.5	-2.1	3.1	-1.2	-1.6	-1.6	-0.1
Trunk fat percentage	2.4	9.6	25.5	-3.1	-2.7	-2.9	4.7	2.3	-0.3	-5.0	-0.7	3.0	3.1	3.2	2.8
Hand grip strength (right)	0.9	2.4	6.5	1.1	2.5	1.7	2.5	-0.7	-1.2	0.9	1.2	-1.5	-1.3	-1.7	-1.3
Townsend deprivation index at recruitment	0.3	0.4	1.9	0.2	0.1	-0.3	1.3	1.4	-0.8	-0.5	0.5	-0.3	0.0	0.4	-0.4
Current tobacco smoking	0.3	0.6	1.3	1.0	0.8	1.1	0.3	0.3	0.7	0.7	-0.2	-0.9	-0.6	-0.2	-1.1
Average weekly fortified wine intake	0.4	0.5	1.1	0.8	0.5	0.9	-0.8	0.1	0.2	0.6	0.3	-0.9	-0.8	-1.0	-0.3
Maternal smoking around birth	0.7	1.1	3.5	0.5	1.9	1.0	0.6	1.1	-1.0	0.6	1.0	-0.9	-1.3	-1.3	-0.0
Fed-up feelings	0.5	0.8	3.1	-0.7	-0.7	-0.5	1.8	0.9	0.8	-0.5	-0.7	1.0	0.8	0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.7	-0.3	-0.6	-0.2	1.6	0.6	0.5	-0.3	-1.3	1.0	0.9	1.3	0.8
Relative age voice broke	0.8	1.1	2.5	0.7	0.9	0.8	-1.3	-0.9	1.6	1.1	1.2	-0.9	-1.1	-1.2	-0.8
Taking other prescription medications	0.3	0.4	1.6	0.3	0.4	-0.2	-1.3	-0.8	0.9	0.2	0.7	-0.3	-0.2	-0.5	-0.7
Age when periods started (menarche)	1.0	2.5	4.7	1.7	0.9	2.2	-1.4	-2.0	0.8	1.9	-0.5	-1.7	-1.5	-1.1	-2.1
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	11.3	-1.4	-0.9	-0.8	-3.4	-0.3	-0.9	-0.1	-1.7	1.1	1.2	0.9	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	5.8	1.1	0.7	2.2	2.4	-1.0	0.8	1.6	-0.1	-1.1	-0.8	-0.5	-1.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	0.2	-0.0	-0.4	0.3	-0.6	0.3	-0.7	0.2	-0.3	-0.3	-0.0	0.2
Qualifications: CSEs or equivalent	0.4	0.5	2.1	0.7	0.7	1.5	1.3	0.2	0.2	-0.1	0.7	-0.6	-0.5	-0.2	-0.5
Serious illness, injury or assault to yourself	0.3	0.3	1.1	0.2	0.4	0.7	-0.4	-0.2	0.1	1.1	0.1	-0.6	-0.2	-0.8	-0.9
High blood pressure	0.2	0.4	2.0	-0.1	-0.6	-0.7	-1.4	0.6	1.1	-0.2	-0.7	0.5	0.3	0.2	0.2
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.2	-0.2	-0.2	-0.8	-0.2	0.8	0.4	-1.1	0.0	0.3	0.7	0.8	-0.0
Multivitamins +/- minerals	2.1	2.7	5.2	1.9	2.3	1.3	0.1	-1.1	1.0	1.4	1.6	-1.9	-2.2	-2.2	-1.2
Stomach or abdominal pain in last month	0.1	0.2	1.0	0.2	0.2	-0.2	0.5	-0.2	-1.0	-0.8	0.3	-0.0	0.1	0.1	-0.1
Supplements: Glucosamine	2.0	2.6	5.5	1.2	1.9	1.5	-1.8	-1.3	-0.2	1.1	1.5	-1.9	-2.0	-2.3	-1.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.7	0.3	0.1	0.1	-0.1	1.0	-1.3	0.4	0.2	0.2	-0.0	0.3	0.1
Medication: Atenolol	1.4	1.8	3.5	-1.5	-1.9	-1.4	0.5	1.7	-0.4	-1.1	-0.4	1.6	1.6	0.9	1.6
Medication: Levothyroxine sodium	1.5	2.6	8.0	1.2	0.6	1.2	2.8	-1.6	2.3	0.9	2.0	-1.2	-0.8	-1.1	-1.8
Sitting height	1.3	9.6	39.8	-2.0	0.7	-1.9	6.3	3.2	-5.5	-4.5	0.6	1.0	0.6	0.1	2.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.7	0.0	0.1	-0.1	0.1	0.8	0.2	-0.3	0.0	-0.2	-0.2	-0.2	0.1
High blood pressure (mother)	1.6	2.2	4.4	2.0	2.1	1.4	-0.2	-2.0	0.1	1.6	1.4	-1.6	-1.6	-1.0	-1.5
Body mass index (BMI)	0.5	2.2	13.2	-1.0	-0.1	-0.6	3.6	0.7	0.7	-2.4	1.1	0.9	0.8	1.3	0.8
Impedance of leg (left)	1.0	4.7	11.6	-1.9	-3.4	-2.5	-1.0	1.2	-0.2	-0.8	-3.0	2.4	2.7	2.5	1.9
Leg predicted mass (left)	1.5	7.7	43.6	0.3	3.5	1.2	6.6	1.2	-3.5	-2.0	3.2	-1.4	-1.7	-1.7	-0.2
Trunk fat mass	1.8	7.9	36.5	-2.5	-1.1	-2.0	6.0	2.3	-1.5	-4.7	0.3	2.0	2.0	2.1	2.3
Waist circumference	1.1	4.2	28.9	-1.2	0.5	-1.2	5.4	1.3	-0.8	-3.2	0.8	1.0	1.0	1.4	1.0
Number of incorrect matches in round	0.2	0.4	2.8	0.2	0.1	-0.6	0.1	-0.9	1.7	0.7	0.2	-0.2	-0.2	-0.2	-0.4
Past tobacco smoking	0.2	0.4	3.5	0.0	-0.6	0.2	-0.2	0.0	-0.5	-0.4	-1.9	0.5	0.5	0.3	0.5
Alcohol usually taken with meals	1.0	1.6	2.6	-0.8	-1.2	-1.5	-0.8	1.1	-0.9	-1.0	-1.4	1.5	1.6	1.5	1.6
Nervous feelings	0.2	0.4	1.5	1.2	0.3	0.4	-0.8	-0.3	-0.3	1.0	-0.7	-0.4	-0.4	-0.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.7	0.4	0.2	0.6	-0.3	-0.1	0.8	0.8	0.5	-0.3	-0.3	-0.4	-0.4
Hearing difficulty/problems with background noise	0.7	1.0	2.6	0.4	0.5	0.8	-0.0	-1.6	1.6	1.5	1.6	-0.8	-0.6	-0.5	-0.6
Hair/balding pattern: Pattern 2	0.2	0.3	1.5	-0.0	-0.0	0.3	0.7	0.3	0.9	-1.2	0.4	0.3	-0.2	0.2	0.2
Had menopause	7.4	9.2	18.7	-4.3	-3.3	-4.1	-1.2	1.4	0.2	-2.2	-2.2	3.7	3.8	3.4	3.3
Had other major operations	1.0	1.2	3.1	-1.8	-0.5	-1.6	-1.4	-0.8	-1.1	-0.7	0.1	0.9	1.4	0.8	0.6
Forced vital capacity (FVC)	2.6	10.1	25.3	2.0	5.0	3.4	1.8	-1.4	-3.2	2.5	3.5	-3.3	-3.7	-4.1	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	4.8	1.1	1.0	2.2	2.0	-1.9	1.7	2.1	0.4	-1.5	-1.1	-0.8	-1.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.2	-0.0	0.8	-0.5	-1.5	-1.1	0.2	1.4	1.0	-0.4	-0.6	-0.9	-0.4
Qualifications: None of the above	0.7	1.5	3.6	-0.7	-1.4	-1.6	0.8	1.1	1.9	-0.9	-1.0	1.2	1.0	1.1	1.5
Financial difficulties in last 2 years	0.8	1.1	2.2	-0.9	-0.9	-0.7	1.0	1.5	-0.9	-0.4	-0.9	1.1	1.4	1.5	0.8
Mouth/teeth dental problems	0.3	0.4	1.9	-0.1	-0.3	-0.8	1.4	0.4	-0.6	-1.0	-0.7	0.4	0.1	0.2	0.4
Heart attack	1.7	2.1	4.6	-1.7	-1.8	-2.1	1.1	1.1	-0.0	-2.0	-1.3	1.5	1.3	1.0	1.2
Allergy	0.2	0.4	1.7	-0.5	-0.5	-0.1	0.9	-0.1	-1.3	0.7	-0.9	0.4	0.2	0.2	0.5
Pain all over the body in last month	1.3	1.4	3.6	1.1	1.3	1.9	0.8	-0.8	1.0	0.8	1.0	-1.3	-1.2	-1.3	-1.2
Diabetes (self-reported)	0.1	0.2	0.7	-0.7	0.4	-0.8	-0.1	0.5	-0.4	0.1	0.3	0.3	0.3	0.5	-0.1
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.1	-1.3	-1.2	-1.8	0.7	1.5	-0.9	-1.0	-1.2	1.7	1.9	2.0	1.5
Medication: Ramipril	0.8	1.0	2.5	-1.6	-0.5	-1.4	0.1	1.3	-0.7	-0.2	-1.4	0.9	0.8	0.5	1.4
Medication: Simvastatin	0.5	0.7	2.4	0.1	0.5	0.4	-1.4	-0.3	1.6	0.7	1.0	-0.7	-0.5	-1.0	-0.7
Fluid intelligence score	0.2	0.3	2.4	-0.4	-0.3	0.3	-0.2	-0.0	-1.5	0.5	0.6	0.1	0.4	0.3	0.5
Illnesses of siblings	0.5	0.8	4.9	0.1	0.5	0.3	2.2	0.2	-1.8	-0.8	-0.1	0.0	0.0	-0.1	-0.0
Neuroticism score	0.2	0.3	2.6	0.1	-0.5	0.8	1.6	0.4	0.1	0.1	-0.5	0.3	0.2	0.0	0.1
Weight	1.3	6.6	49.8	-1.1	1.5	-0.3	7.1	1.6	-2.5	-3.3	2.1	0.2	0.0	0.1	0.9
Impedance of arm (right)	0.5	2.5	8.6	-1.0	-2.5	-1.1	-2.9	0.9	0.2	-0.9	-2.5	1.1	1.3	0.9	1.0
Arm fat percentage (right)	0.8	3.1	10.6	-1.5	-1.4	-1.3	3.1	1.0	1.1	-3.3	0.3	1.5	1.5	1.7	1.3
Trunk fat-free mass	2.0	11.5	48.3	1.1	4.9	2.1	7.0	0.6	-4.5	-0.4	3.8	-2.4	-2.8	-3.1	-0.9
Hip circumference	1.0	4.4	35.6	-0.2	1.4	0.4	6.0	0.3	-0.8	-2.7	2.5	-0.5	-0.6	-0.3	-0.2
Time employed in main current job	0.9	1.0	5.4	0.3	-0.6	-0.3	1.7	-1.4	2.3	-0.6	0.4	-0.3	-0.6	-0.2	-0.7
Alcohol intake versus 10 years previously	2.9	4.4	6.1	-2.0	-2.0	-2.3	1.4	2.0	-1.7	-2.0	-2.5	2.4	2.3	2.2	2.0
Father’s age at death	0.4	0.5	3.5	0.0	0.0	0.3	1.9	-0.4	0.5	0.4	1.3	-0.5	-0.4	-0.4	-0.4
Worrier / anxious feelings	0.8	1.5	4.1	-0.4	-1.9	-1.0	0.6	-0.7	1.2	0.6	-2.0	1.1	1.5	1.6	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	2.8	-0.3	-0.4	-0.3	1.7	0.1	0.4	0.1	0.4	0.5	0.3	0.8	0.2
Falls in the last year	0.4	0.6	2.2	-1.0	0.0	-1.2	-1.5	-0.5	0.1	-0.2	0.6	0.3	0.9	0.9	0.1
Hair/balding pattern: Pattern 3	0.4	0.6	2.5	-0.5	-0.9	-0.6	-1.3	0.2	-1.6	-0.1	-0.4	0.7	0.8	0.4	0.4
Number of live births	0.4	0.6	1.2	-0.8	-0.5	-1.0	0.6	1.1	-0.1	-0.9	0.8	0.8	0.5	0.8	0.7
Forced expiratory volume in 1-second (FEV1)	2.5	8.5	21.3	1.4	4.6	3.0	2.6	-1.0	-4.0	2.2	3.0	-2.5	-3.1	-3.7	-1.7
Pulse rate	1.8	3.1	7.4	-1.9	-1.7	-2.7	-0.6	1.2	1.1	-1.3	-0.6	1.9	2.4	2.2	2.0
Happiness	0.4	0.4	1.0	-1.0	-0.6	-1.0	-0.9	0.5	-0.3	0.5	0.2	0.5	0.5	0.7	0.7
Noisy workplace	1.7	2.1	3.5	1.2	1.5	1.5	0.0	-1.8	1.8	1.7	1.0	-1.7	-1.3	-0.9	-1.9
Qualifications: A levels/AS levels or equivalent	0.3	0.7	4.3	0.5	0.1	0.5	-0.8	-2.1	-0.0	0.6	0.8	-0.7	0.0	0.1	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.8	0.3	1.2	1.7	-0.4	-0.8	-1.0	1.1	1.2	-1.1	-1.0	-1.1	-1.3
Mouth/teeth dental problems: Dentures	0.6	1.0	5.4	0.3	0.5	0.3	-1.0	-0.7	2.3	1.0	1.0	-0.6	-1.0	-0.9	-0.5
Asthma	1.0	1.9	5.6	1.3	0.6	1.3	-2.4	-2.0	1.4	-0.7	0.8	-1.1	-0.9	-0.9	-1.8
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	6.1	-1.5	-2.0	-1.5	-1.0	2.5	0.3	-1.4	-1.6	1.7	1.5	1.2	2.3
Medication: Cholesterol lowering	0.3	0.4	1.3	-0.5	-0.7	-0.7	1.2	0.7	1.0	-0.2	-0.1	0.4	0.4	0.2	0.5
Depression (self-reported)	0.1	0.1	0.4	0.2	0.3	-0.2	-0.6	-0.4	0.3	0.2	-0.1	-0.1	0.0	0.1	-0.3
Medication: Lansoprazole	1.0	1.2	2.5	-1.6	-1.0	-1.4	-0.3	0.9	-0.1	-0.4	-1.2	1.4	1.2	0.8	1.4
Prospective memory result	1.3	1.6	2.7	-1.6	-1.6	-1.3	-0.0	0.8	0.4	-1.1	-1.6	1.4	1.6	1.5	1.3
Lung cancer (father)	0.9	1.1	3.0	1.0	0.2	0.9	1.5	-0.9	1.7	1.3	1.3	-0.7	-0.6	-0.5	-0.8
Illnesses of mother	0.2	0.3	1.7	-0.3	-0.3	-0.1	-0.8	1.3	-0.4	-0.0	-0.6	0.2	0.1	-0.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.5	18.7	1.1	4.3	2.8	2.5	-0.3	-3.7	2.6	2.6	-2.3	-2.9	-3.5	-1.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.3	0.2	0.6	0.1	-0.1	-0.9	0.4	0.4	-0.1	0.4	0.5	-0.2
Impedance of arm (left)	0.9	4.1	10.8	-2.0	-3.3	-2.1	-1.9	1.3	0.0	-1.6	-2.6	2.1	2.3	1.7	1.8
Arm fat mass (right)	1.1	4.7	25.2	-1.9	-0.5	-1.2	5.0	1.5	-0.9	-3.6	0.8	1.4	1.4	1.5	1.6
Trunk predicted mass	2.0	11.2	48.2	1.0	4.8	2.1	6.9	0.7	-4.5	-0.4	3.8	-2.3	-2.8	-3.0	-0.8
Standing height	1.3	13.1	63.4	-0.3	3.5	0.6	8.0	2.3	-7.4	-2.2	2.4	-1.3	-1.7	-2.5	0.5
Length of working week for main job	2.3	2.5	5.8	1.7	1.7	2.1	0.1	-0.4	1.1	1.3	1.1	-1.6	-2.4	-2.3	-1.1
Exposure to tobacco smoke at home	1.1	1.2	3.6	0.1	1.8	0.4	0.9	-0.2	0.8	0.8	1.6	-1.0	-1.3	-1.9	-0.4
Breastfed as a baby	0.7	0.9	1.8	-0.8	-1.3	-0.4	-0.1	1.0	-1.0	0.0	-1.3	1.0	1.2	1.1	0.6
Tense / ‘highly strung’	0.3	0.4	1.1	-0.2	-0.9	-0.4	0.2	0.5	-0.3	-0.1	-1.0	0.9	0.8	0.6	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	4.0	1.7	1.3	1.2	-0.7	-1.9	0.9	1.9	1.5	-1.5	-1.0	-1.0	-2.0
Hair/balding pattern: Pattern 4	0.1	0.3	1.2	0.6	0.2	-0.1	-0.7	0.1	-0.6	1.1	-0.2	-0.2	-0.4	-0.6	-0.0
Birth weight of first child	1.2	2.2	9.8	0.1	2.4	0.4	2.2	-0.5	-3.1	1.3	0.4	-1.1	-0.7	-1.4	-0.8
Peak expiratory flow (PEF)	0.6	1.4	4.1	0.0	1.9	1.1	1.5	-0.6	-2.0	0.2	0.8	-0.8	-1.1	-1.4	-1.1
Pulse wave reflection index	1.6	2.0	6.2	1.8	1.4	2.5	-0.7	-0.7	-1.6	1.2	0.5	-1.4	-1.4	-1.0	-1.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.7	-0.4	-0.4	-0.4	-0.9	0.8	-1.3	0.0	-1.1	0.5	0.7	0.8	0.2
Loud music exposure frequency	3.6	3.9	7.1	-1.6	-2.2	-1.9	-1.0	1.3	-1.9	-2.0	-2.7	2.2	2.3	2.2	1.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.1	-0.0	0.7	0.8	-0.5	-0.1	-0.6	1.4	1.5	-0.9	-0.5	-0.9	-0.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.0	0.2	1.2	1.7	-1.6	0.3	-0.6	1.4	0.6	-0.9	-0.7	-0.8	-0.9
Blood clot in the leg (DVT)	1.8	2.3	5.8	-2.1	-1.5	-1.7	0.8	1.5	-0.0	-0.9	-0.9	1.7	1.8	1.2	2.4
Medication: Paracetamol	3.4	5.6	10.3	-2.2	-3.2	-3.1	0.0	2.7	-0.1	-2.6	-1.9	2.5	2.5	2.7	2.2
Headache pain in last month	0.4	0.6	3.2	-1.0	-0.7	-0.5	0.1	1.8	-0.4	-0.5	-0.8	0.7	0.5	0.6	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.0	0.5	1.3	1.4	-0.5	-1.0	-0.7	0.1	1.1	-1.0	-1.1	-1.0	-1.1
Glaucoma (self-reported)	5.0	5.9	9.5	-2.9	-3.1	-2.8	1.4	2.1	-1.0	-2.8	-2.2	2.8	2.3	1.9	2.9
Gout (self-reported)	0.3	0.5	2.0	-0.3	-0.3	-0.3	1.4	0.0	0.4	-0.4	-1.4	0.6	0.5	0.5	0.3
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	19.8	0.0	-0.6	-0.1	4.5	-0.3	1.2	-0.7	1.4	0.1	0.4	0.2	-0.3
Medication: Amlodipine	1.1	1.5	4.5	-1.1	-1.2	-1.2	0.1	0.1	-0.5	-1.5	-2.1	1.5	1.4	1.2	1.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	5.4	0.1	-0.4	0.1	-2.3	-0.0	0.9	-0.3	-0.1	-0.1	-0.2	-0.5	-0.4
Birth weight	2.2	4.7	10.1	1.0	2.9	2.6	3.2	1.0	-2.2	2.4	1.9	-1.9	-1.9	-2.7	-0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	0.5	0.9	0.9	-1.0	-0.1	0.4	0.7	0.5	-0.8	-0.7	-0.9	-0.6
High blood pressure (siblings)	0.8	1.2	2.9	-1.0	-1.2	-1.7	-1.0	0.3	1.4	-0.4	-0.9	1.1	1.2	1.4	0.9
Forced vital capacity (FVC), Best measure	2.5	9.0	21.5	1.8	4.6	3.2	2.0	-0.5	-3.1	2.7	3.1	-3.0	-3.5	-4.0	-2.0
Body fat percentage	2.1	8.4	21.3	-2.7	-2.5	-2.7	4.6	2.0	0.3	-4.5	-0.5	2.8	3.0	3.2	2.6
Leg fat percentage (right)	1.5	5.3	15.5	-2.1	-1.9	-2.3	3.9	1.2	1.0	-3.3	0.0	2.2	2.4	2.8	2.0
Arm fat-free mass (right)	1.6	8.0	49.7	-0.6	3.0	0.2	7.0	1.5	-4.5	-2.1	2.9	-0.4	-0.7	-0.9	0.7
Exposure to tobacco smoke outside home	3.1	4.1	7.4	-2.1	-1.8	-1.9	0.3	2.1	-2.5	-2.7	-2.5	2.3	1.8	1.7	1.6
Comparative body size at age 10	1.2	3.2	12.6	0.8	2.7	1.5	0.9	-1.3	1.4	1.5	3.5	-1.7	-1.6	-1.6	-1.2
Number of full brothers	0.5	0.6	1.6	-0.5	-0.3	-0.3	-0.1	1.1	-1.3	-1.2	-0.9	0.5	0.4	0.8	0.5
Worry too long after embarrassment	0.2	0.3	0.8	-0.5	-0.9	-0.4	0.6	-0.5	-0.2	0.8	-0.3	0.6	0.5	0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.0	-1.2	-1.2	-1.2	-1.4	0.7	1.0	0.0	-0.6	1.1	1.0	0.7	0.8
Wheeze or whistling in the chest in last year	0.3	0.5	2.6	0.4	0.4	0.9	-0.4	-0.9	1.6	-0.4	0.1	-0.3	-0.3	-0.5	-0.7
Number of children fathered	0.9	1.0	3.5	-1.3	-0.9	-0.5	1.9	0.5	-0.3	-1.3	-0.1	1.1	0.8	0.6	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.5	0.8	0.2	1.2	0.6	-0.6	-0.0	0.2	1.0	-0.4	0.1	-0.1	-0.4
Age at first live birth	1.0	1.8	4.7	2.1	0.7	1.1	-1.4	-1.5	0.4	2.2	-0.2	-1.3	-1.1	-1.0	-1.6
Pulse wave peak to peak time	0.2	0.2	0.4	-0.4	-0.1	-0.6	0.6	0.4	0.3	-0.6	-0.4	0.1	-0.4	-0.5	0.4
Health satisfaction	0.2	0.3	1.0	-0.7	0.4	-0.6	-0.5	-0.7	1.0	0.1	0.9	0.1	0.1	0.3	-0.1
Shortness of breath walking on level ground	0.7	0.9	4.4	-0.4	0.2	-0.5	1.9	-0.6	2.1	0.2	1.1	-0.1	-0.2	0.2	-0.3
Qualifications: College or University degree	0.3	1.0	5.7	-0.2	0.2	1.0	-2.4	-0.9	-1.7	1.0	-0.3	-0.1	0.3	0.0	-0.3
Eye problems/disorders: None of the above	0.6	0.7	1.6	1.3	0.8	0.7	-1.2	0.3	-0.7	1.0	0.1	-1.0	-0.8	-0.4	-0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.1	-1.0	-0.3	-0.4	-1.4	0.8	-1.4	-1.1	-0.1	0.5	0.8	0.7	0.6
Emphysema/chronic bronchitis	0.3	0.3	2.0	0.1	0.0	-0.2	0.9	0.3	1.4	-0.5	0.7	-0.2	-0.5	-0.2	-0.2
Medication for pain relief, constipation, heartburn	3.4	5.9	10.8	1.8	3.2	2.5	-0.8	-3.3	-0.7	2.2	1.8	-2.7	-2.7	-2.8	-2.9
Neck or shoulder pain in last month	0.7	1.0	4.8	0.8	0.8	1.1	2.2	0.1	0.9	0.0	1.9	-0.4	-0.2	0.2	-0.2
Medication: Blood pressure	0.9	1.5	3.1	-0.6	-1.8	-1.6	-0.0	1.4	0.8	-0.7	-1.4	1.4	1.2	1.2	1.6
Angina (self-reported)	0.4	0.6	2.6	-0.7	-0.8	-1.6	0.2	0.3	0.5	-0.3	0.5	0.9	0.8	0.6	0.8
Migraine (self-reported)	0.9	1.1	2.6	1.3	0.9	1.6	-0.4	-0.6	0.6	-0.0	1.2	-1.1	-1.1	-0.8	-1.6
Medication: Ibuprofen	2.0	2.4	6.2	-1.5	-2.0	-1.4	-0.2	2.5	0.8	-1.0	-1.4	1.5	1.4	1.1	2.2
Medication: Allopurinol	0.3	0.5	3.1	-0.3	0.0	-0.2	1.1	-0.1	0.4	-0.4	-1.8	0.4	0.4	0.5	0.3
Medication: Omeprazole	0.8	1.0	2.2	-0.8	-1.1	-0.8	0.8	1.5	-0.3	-1.4	-0.7	1.2	0.8	0.8	1.0
Medication: Seretide 50 evohaler	0.3	0.4	3.2	-0.0	-0.4	0.5	-0.1	-0.6	1.8	-0.8	-0.1	0.1	-0.1	-0.3	-0.0
Mean time to correctly identify matches	0.8	1.5	3.5	0.3	1.2	0.7	-0.9	-1.9	1.7	1.5	1.1	-1.0	-1.0	-1.4	-1.1
Heart disease (mother)	0.7	0.8	4.6	-0.5	-0.7	-0.2	2.1	1.2	1.2	-0.7	0.1	0.4	0.3	0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.7	-0.9	-0.9	-0.7	1.9	0.5	0.1	-1.1	-1.3	1.1	1.2	1.6	1.1
Whole body fat mass	1.6	6.6	34.0	-2.0	-0.7	-1.7	5.8	2.0	-1.3	-4.2	0.6	1.7	1.7	1.9	2.0
Leg fat mass (right)	1.4	5.5	30.5	-1.8	-0.6	-1.6	5.5	1.9	-0.9	-3.6	0.8	1.6	1.5	1.8	1.9
Arm predicted mass (right)	1.6	8.3	50.7	-0.4	3.2	0.5	7.1	1.5	-4.6	-1.8	3.0	-0.7	-1.0	-1.1	0.5
Pulse rate, automated reading	0.8	2.7	4.8	-1.6	-2.0	-2.2	-0.7	2.0	1.3	-0.4	-1.2	1.8	2.1	1.5	1.8
Alcohol intake frequency.	0.3	0.7	2.0	-0.5	-0.9	-0.6	-0.2	0.1	-0.4	-1.4	-0.9	0.9	0.9	1.4	0.2
Comparative height size at age 10	0.8	4.4	21.9	-0.3	2.4	0.4	4.7	1.2	-3.6	-0.8	2.1	-0.8	-1.0	-1.8	0.4
Number of full sisters	0.5	0.6	1.5	0.4	0.6	1.1	-0.1	1.0	-1.0	0.3	0.1	-0.7	-1.2	-1.0	-0.1
Suffer from ‘nerves’	0.1	0.2	0.6	0.3	0.3	0.4	0.4	-0.8	0.2	0.7	-0.0	-0.2	-0.1	-0.1	-0.6
Overall health rating	0.2	0.5	4.0	-0.4	0.4	-0.2	-0.3	0.1	2.0	-0.1	1.2	-0.2	-0.3	-0.4	0.1
Chest pain or discomfort	0.2	0.3	1.2	-0.6	0.3	-0.4	0.4	-0.7	0.8	0.3	1.1	0.0	-0.3	-0.1	0.2
Had major operations	0.6	0.7	2.2	1.5	0.8	0.3	0.3	-0.7	-0.1	1.4	1.2	-0.9	-0.7	-0.2	-0.8
Age at last live birth	0.5	0.7	2.5	1.6	0.4	0.5	-0.1	-0.5	0.4	1.5	0.6	-0.9	-0.5	-0.2	-1.1
Family relationship satisfaction	0.2	0.2	1.4	-0.2	0.3	-0.1	-0.4	0.3	-0.2	0.7	1.2	0.0	-0.0	0.0	0.4
Leg pain on walking	0.5	0.6	2.1	0.5	0.8	1.0	-0.1	-0.2	1.5	1.1	1.0	-0.7	-0.7	-0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.7	0.2	0.1	0.5	-0.3	0.1	-0.5	-0.8	-0.1	-0.3	0.1	-0.1	-0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.8	0.1	0.1	0.2	0.1	0.6	1.7	1.0	1.0	-0.5	-0.8	-1.2	-0.1
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.2	2.0	1.3	0.9	-0.5	-0.6	2.0	-0.1	1.1	-1.4	-1.6	-1.0	-1.5
Medication: Aspirin	0.7	1.0	1.7	-0.5	-1.1	-1.3	0.8	1.1	-0.5	-1.1	-0.1	1.2	1.2	1.2	1.1
Supplements: Vitamin C	0.4	0.5	2.4	0.1	-1.3	-0.1	1.6	-0.1	0.5	0.3	-0.4	0.4	0.7	0.5	0.2
Knee pain experienced in last month	1.2	1.9	3.3	-1.7	-1.8	-1.3	-0.3	1.8	0.0	-1.5	-0.6	1.7	1.5	1.2	1.6
Hypertension (Self-reported)	0.3	0.7	1.6	-0.5	-0.8	-1.1	-1.2	1.3	0.3	-0.7	-1.1	0.9	0.7	0.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.8	-1.0	-1.3	-1.0	0.1	1.3	1.0	-0.8	-1.2	1.2	0.8	1.0	0.9
Illnesses of father: Heart disease	4.0	5.5	10.0	-2.8	-2.4	-2.7	-1.7	1.8	-0.8	-1.5	-2.1	2.8	2.9	2.4	3.2
Illnesses of siblings: Diabetes	0.6	0.7	2.6	0.2	0.7	0.7	-1.6	-0.4	0.8	1.2	0.7	-0.5	-0.9	-1.0	-0.4
Smoking status: Previous	0.2	0.3	3.2	-0.2	0.1	-0.3	0.1	-0.3	0.4	0.3	1.8	-0.2	-0.3	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	20.6	-0.6	1.6	0.2	4.5	1.3	-3.6	-0.0	0.6	-0.3	-0.2	-0.8	0.8
Whole body fat-free mass	1.8	10.1	49.8	0.7	4.3	1.7	7.1	1.0	-4.2	-1.2	3.6	-1.9	-2.3	-2.5	-0.5
Leg fat-free mass (right)	1.4	7.6	41.0	0.5	3.6	1.4	6.4	1.2	-3.4	-1.8	3.1	-1.5	-1.9	-1.9	-0.3
Arm fat percentage (left)	1.2	4.8	13.5	-2.0	-1.8	-1.9	3.4	1.5	0.7	-3.7	-0.0	2.1	2.2	2.3	1.9
Average weekly red wine intake	1.1	1.6	3.7	-1.5	-1.4	-1.5	-1.3	1.9	-0.9	-0.9	-0.0	1.3	1.0	0.3	1.8
Handedness (chirality/laterality): Left-handed	2.3	2.8	9.1	-1.1	-1.8	-0.3	-2.5	1.5	-1.6	-1.3	-3.0	1.5	1.2	1.4	1.5
Mood swings	0.2	0.3	1.0	0.2	-0.7	0.9	1.0	0.8	0.7	0.0	-0.4	0.3	0.1	-0.0	0.3
Loneliness, isolation	0.3	0.4	2.5	-0.7	-0.1	-0.4	-0.2	1.6	-0.1	-0.2	-0.5	0.7	0.5	0.2	0.7
Long-standing illness, disability or infirmity	0.5	0.7	1.8	-1.0	-0.9	-1.3	0.5	0.6	1.3	-0.8	0.1	0.7	0.9	0.7	0.3
Ever had bowel cancer screening	0.7	0.9	2.1	0.8	1.4	0.8	-0.1	0.4	-1.2	-0.1	0.6	-1.0	-1.2	-1.5	-0.9
Diabetes diagnosed by doctor	0.3	0.4	1.3	-1.1	0.2	-1.2	-0.1	0.5	-0.5	0.1	-0.2	0.8	0.8	1.0	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.1	0.1	0.1	-0.2	-0.1	0.2	0.2	0.3	-0.2	0.1	-0.2	-0.1
Friendships satisfaction	0.4	0.5	1.7	-0.7	-0.6	-1.3	-1.1	0.3	-0.5	0.2	-0.4	0.8	0.6	0.8	0.8
Qualifications: nursing, teaching	1.3	2.0	3.6	1.1	1.4	1.4	-0.7	-1.9	-0.4	1.2	1.9	-1.6	-1.4	-1.4	-1.6
Commuting to job workplace: Walk	1.0	1.0	4.5	-0.0	-1.0	-0.4	2.1	1.5	-0.7	-0.8	-0.3	0.6	0.9	1.4	0.5
Eye problems/disorders: Cataract	0.2	0.3	0.7	-0.8	-0.2	-0.5	0.4	-0.0	-0.1	-0.5	0.3	0.7	0.6	0.4	0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.3	-0.3	-0.9	-0.1	-0.1	-0.0	-1.5	-0.1	-0.4	0.4	1.0	0.9	-0.3
Medication for cholesterol	2.0	3.0	4.7	2.2	1.2	2.1	2.2	-1.7	1.9	2.0	0.7	-1.9	-1.5	-1.0	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.8	-0.9	-1.4	-0.6	0.1	0.4	-0.4	-0.4	-1.7	0.9	1.5	1.4	0.3
Back pain experienced in last month	0.5	0.8	4.9	-0.6	-0.5	-0.8	2.2	0.4	1.0	-0.8	-0.0	0.5	0.2	0.3	1.1
Mineral and other dietary supplements	0.5	0.7	1.4	-1.0	-0.7	-1.0	0.1	0.6	-0.3	-1.2	-1.0	0.9	1.0	1.2	0.5
Breast cancer (self-reported)	2.8	3.4	6.4	-2.5	-2.1	-1.7	0.0	1.1	-1.3	-1.8	-1.8	2.1	2.3	2.0	1.9
Asthma (self-reported)	0.9	1.8	5.9	1.2	0.5	1.1	-2.4	-2.0	1.5	-0.8	0.9	-1.0	-0.8	-1.0	-1.8
Osteoporosis (self-reported)	1.6	2.0	4.4	-1.8	-0.9	-1.7	-2.1	1.1	-1.6	-1.5	-1.4	1.3	1.0	0.6	1.0
Osteoarthritis (self-reported)	1.3	1.7	12.8	0.6	0.5	0.2	-3.6	-1.1	1.5	1.0	0.6	-0.7	-0.8	-0.7	-0.9
Medication: Aspirin	0.2	0.3	0.7	-0.1	-0.6	-0.8	0.6	0.3	0.2	-0.5	0.4	0.5	0.7	0.6	0.4
Medication: Gliclazide	0.5	0.6	1.6	0.5	1.3	0.3	0.0	-0.4	0.6	0.9	1.2	-0.7	-0.8	-0.4	-1.0
Illnesses of father: None of the above (group 1)	2.3	2.8	7.6	2.1	1.3	1.9	2.8	-1.4	0.0	0.6	0.9	-1.7	-1.6	-1.5	-2.4
Smoking status: Current	0.4	0.7	1.6	1.0	1.1	1.3	0.4	0.2	0.8	0.7	-0.0	-1.0	-0.8	-0.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	5.4	0.2	1.6	1.2	0.1	-0.7	-1.2	2.3	1.0	-0.5	-0.6	-0.9	-0.2
Whole body water mass	1.8	10.0	49.0	0.6	4.3	1.7	7.0	1.1	-4.3	-1.3	3.7	-1.9	-2.3	-2.5	-0.5
Leg predicted mass (right)	1.4	7.6	40.4	0.5	3.6	1.4	6.4	1.2	-3.4	-1.8	3.1	-1.5	-1.9	-1.9	-0.3
Arm fat mass (left)	1.2	4.7	24.9	-1.9	-0.5	-1.3	5.0	1.7	-1.0	-3.5	0.8	1.5	1.4	1.5	1.7
Number of self-reported non-cancer illnesses	1.1	1.8	4.5	-0.8	-1.6	-1.9	0.0	0.2	0.8	-1.7	-0.4	1.5	2.1	2.1	0.7
Average weekly champagne plus white wine intake	0.7	1.0	2.5	-0.9	-1.6	-0.9	0.7	0.7	0.4	-1.1	-0.7	1.1	1.2	0.6	1.5
Miserableness	0.1	0.1	0.9	0.1	-0.3	0.5	0.9	0.5	-0.1	-0.2	-0.2	0.3	-0.0	0.0	0.2
Guilty feelings	0.3	0.4	0.9	0.7	0.1	0.7	-0.3	-0.8	0.8	0.8	0.1	-0.4	-0.4	-0.5	-1.0
Wears glasses or contact lenses	2.3	2.7	6.0	-2.1	-2.4	-1.4	1.1	1.3	0.9	-0.7	-0.4	1.8	2.0	2.2	1.9
Ever taken oral contraceptive pill	0.4	0.4	1.7	0.2	0.7	0.6	0.5	0.2	-0.6	-0.3	-0.9	-0.6	-0.9	-1.3	-0.5
Hearing aid user	0.2	0.2	0.6	0.3	-0.2	0.4	0.7	0.3	-0.6	-0.7	-0.8	0.2	0.4	0.3	0.2
Mother’s age at death	1.7	2.1	4.2	-1.4	-1.5	-1.8	0.4	0.5	-1.0	-1.3	-0.9	1.6	2.0	1.9	1.8
Financial situation satisfaction	0.7	0.9	3.2	-0.7	-0.3	-1.3	0.2	0.7	-0.9	-0.5	-0.2	1.2	1.3	1.8	0.4
Tinnitus: Yes, now most or all of the time	2.9	3.4	11.6	-2.2	-1.3	-1.2	1.9	1.7	-3.4	-0.7	-1.8	1.8	1.8	1.4	1.4
Commuting to job workplace: Public transport	1.4	1.6	6.8	-1.0	-0.9	-1.2	-1.1	0.5	-2.6	-0.9	-1.3	1.2	1.2	1.1	1.3
Eye problems/disorders: Glaucoma	3.4	4.0	7.9	-2.2	-2.8	-2.4	0.8	1.2	-0.0	-2.4	-1.9	2.4	2.0	1.8	2.2
Medication: Blood pressure	0.2	0.4	2.9	-0.7	0.3	-0.6	-1.7	0.1	0.0	-0.7	0.4	0.2	0.0	-0.7	0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	-1.0	-0.7	-0.8	-0.4	-0.1	0.9	-0.4	-0.1	0.6	0.2	-0.1	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	-0.2	-0.5	-0.7	-0.6	0.4	0.0	0.1	-0.1	0.6	0.6	0.6	0.9
High cholesterol (Self-reported)	0.7	1.3	2.8	-1.2	-1.4	-1.7	-0.3	0.4	-0.0	-1.6	-0.9	1.2	1.5	1.5	0.1
Medication: Bendroflumethiazide	0.3	0.4	3.2	0.4	-0.1	0.2	-1.8	0.1	0.4	-0.7	-0.0	-0.1	-0.6	-0.6	-0.1
Medication: Paracetamol	2.5	3.9	7.8	-1.8	-2.7	-2.8	-0.1	1.8	0.6	-2.4	-1.6	2.1	2.0	2.3	1.7
Medication: Lisinopril	0.5	0.6	1.9	0.7	0.9	0.3	-1.4	-0.9	0.1	-0.7	0.4	-0.7	-0.6	-0.8	-0.9
Medication: Atorvastatin	4.5	5.5	12.0	-2.0	-2.6	-3.5	-0.9	1.8	-2.1	-2.4	-2.6	2.5	2.5	2.5	2.0
Illnesses of father: High blood pressure	1.7	2.1	3.9	1.1	1.8	0.9	-2.0	-1.7	1.5	1.9	0.9	-1.4	-1.4	-1.0	-1.4
Alcohol drinker status: Never	0.1	0.2	0.5	-0.2	-0.3	0.1	0.5	-0.4	0.6	0.1	0.5	0.3	0.4	0.7	0.2
Ever smoked	0.3	0.6	3.1	0.2	1.1	-0.1	-0.2	-0.7	0.2	0.9	1.8	-0.9	-0.5	-0.3	-0.7
Basal metabolic rate	1.6	9.0	53.7	0.1	3.6	1.2	7.3	1.3	-4.0	-1.9	3.2	-1.3	-1.7	-1.8	-0.1
Leg fat percentage (left)	1.4	5.1	14.7	-1.9	-1.9	-2.3	3.8	1.2	1.2	-3.2	0.0	2.2	2.3	2.8	1.8
Arm fat-free mass (left)	1.6	7.9	49.0	0.1	3.4	0.9	7.0	1.0	-3.8	-1.5	3.2	-1.2	-1.5	-1.5	-0.1
Number of operations (self-reported)	1.3	1.9	4.9	1.2	2.1	0.6	-0.1	-2.0	0.1	1.5	2.2	-1.5	-0.8	-0.9	-1.4
Average weekly beer plus cider intake	0.2	0.2	0.9	0.0	0.2	0.7	-0.5	0.5	-0.9	0.8	0.4	-0.3	-0.1	-0.3	-0.1
Irritability	0.3	0.5	2.1	0.5	0.4	1.5	0.9	-0.1	0.7	-0.0	-0.2	-0.5	-0.6	-0.8	-0.7
Risk taking	0.6	0.9	3.3	0.7	1.1	0.5	-0.0	0.7	-1.8	1.0	0.9	-1.0	-0.7	-1.1	-0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.7	-0.8	-0.7	-0.6	-0.0	0.5	-1.3	-1.2	-1.0	1.0	0.9	0.5	0.6
Fractured/broken bones in last 5 years	2.4	3.1	7.1	-2.1	-2.1	-2.3	-0.1	0.7	-0.9	-1.2	-0.8	2.1	2.7	2.4	1.2
Age started oral contraceptive pill	1.1	1.3	10.6	-0.4	-0.2	-1.2	-0.3	-1.2	3.3	0.6	1.3	0.1	0.2	0.3	0.0
Diastolic blood pressure, automated reading	0.5	1.7	5.7	-0.5	-1.7	-1.2	-1.6	0.7	2.4	-0.5	-0.6	1.3	1.1	1.5	0.9
Ever depressed for a whole week	0.4	0.5	1.3	0.3	0.8	-0.2	-0.4	-1.2	0.4	1.1	0.9	-0.7	-0.5	-0.5	-0.8
Unable to work because of sickness or disability	0.3	0.4	1.2	-1.1	0.3	-0.1	0.6	1.1	1.0	0.2	0.4	0.2	-0.2	-0.4	0.6
Commuting to job workplace: Cycle	0.3	0.4	1.3	-0.3	-1.1	-0.6	0.5	-0.5	-0.7	-0.2	-0.3	0.7	0.6	1.1	0.3
Myopia	1.0	1.4	8.4	-0.4	-0.8	-0.4	-1.4	1.0	-2.9	-1.1	-1.1	0.8	0.7	0.9	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.7	2.5	0.5	0.9	1.1	1.1	-0.7	-1.6	0.4	0.4	-0.7	-0.5	-0.3	-0.5
Cholesterol lowering medication	1.3	1.9	3.9	-1.4	-1.2	-1.7	-2.0	1.3	-1.0	-1.7	-0.6	1.4	1.5	1.3	1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	-0.3	-0.6	-0.5	0.6	1.0	0.2	-1.1	-0.3	0.8	0.7	0.5	0.6
Pain experienced in last month	0.2	0.3	1.2	0.1	0.3	-0.4	-0.9	-0.3	-1.1	0.8	0.2	-0.2	0.0	-0.1	-0.1
Supplements: Calcium	0.3	0.3	2.5	-0.1	0.1	-0.5	1.6	0.4	-0.4	0.5	0.4	0.3	0.1	0.3	0.6
Basal cell carcinoma (self-reported)	0.6	0.7	4.6	-0.7	-0.1	-0.7	0.2	1.0	-2.1	-0.6	-0.6	0.6	0.5	0.1	0.9
Heart attack/myocardial infarction (self-reported)	1.6	2.1	4.3	-1.7	-1.9	-2.1	1.2	1.1	0.3	-1.9	-1.0	1.5	1.3	1.0	1.3
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	4.8	-1.9	-1.3	-1.6	0.8	1.2	0.0	-0.9	-0.9	1.6	1.6	1.0	2.2
Heart disease (siblings)	1.8	2.2	3.6	-1.7	-1.7	-1.6	-0.7	1.8	-0.8	-1.9	-1.8	1.5	1.3	1.0	1.2
Alcohol drinker status: Previous	0.3	0.3	1.0	0.3	0.5	1.0	-0.1	-0.8	0.2	-0.1	-0.3	-0.3	-0.7	-0.6	-1.0
Pack years of smoking	0.9	1.4	4.8	2.2	0.9	1.0	-0.1	0.0	1.5	0.6	-0.1	-1.5	-1.5	-1.0	-1.2
Impedance of whole body	1.1	5.8	14.9	-2.1	-3.9	-2.6	-1.8	1.4	-0.4	-1.6	-3.2	2.6	2.8	2.4	2.1
Leg fat mass (left)	1.3	5.0	28.8	-1.6	-0.4	-1.4	5.4	1.8	-0.8	-3.5	0.9	1.4	1.3	1.7	1.7
Arm predicted mass (left)	1.5	7.5	46.6	-0.2	3.1	0.6	6.8	1.4	-3.8	-1.7	3.2	-0.8	-1.2	-1.2	0.4