Hub : Genes

SELRC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1730	0.0410	6.2e-12	0.151	0.115	0.135	0.135	0.149	5.2e-18	7.1e-14	3.8e-16	3.7e-16	1.0e-17
2	GTEx	Adipose Visceral Omentum	0.1490	0.0500	3.8e-05	0.070	NA	0.019	NA	0.026	1.6e-04	NA	3.4e-02	NA	1.6e-02
3	METSIM	Adipose	0.0354	0.0148	8.6e-05	0.040	0.034	0.037	0.033	0.038	9.2e-07	6.7e-06	2.7e-06	8.1e-06	1.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.5	2.3	3.7	-1.9	0.6	1.7
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.4	-0.1	0.3
Depressed Affect (Nagel 2018)	0.5	1.1	1.3	-1.1	1.0	1.0
Depression (Nagel 2018)	0.9	1.4	1.9	-1.4	0.6	1.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.5	0.7	-0.7	-0.6
Neuroticism (Nagel 2018)	1.8	4.2	5.7	-2.4	1.8	2.0
Schizophrenia (2018)	0.4	0.8	1.1	1.1	-0.6	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.5	-0.1	-0.7
Worry (Nagel 2018)	1.1	2.3	4.0	-2.0	1.0	1.4
Alzheimer’s Disease (in mother)	2.1	2.5	3.3	1.8	-1.3	-1.6
Alzheimer’s Disease (in father)	0.4	0.5	0.9	-0.4	0.9	0.6
Alzheimer’s Disease (including proxy)	0.7	1.0	1.8	1.3	-0.2	-1.0
Crohns Disease (2017)	0.0	0.1	0.1	-0.3	-0.2	0.3
Irritable Bowel Disease (IBD)	0.1	0.4	1.0	0.1	-1.0	-0.1
Ulcerative Colitis (UC)	0.9	1.8	3.9	0.7	-2.0	-0.9
Major Depression (MDD)	0.2	0.3	0.8	-0.3	-0.9	-0.0
Reaction Time	0.1	0.3	0.4	-0.6	0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.1	2.0	1.4	-0.4	-1.0
Breast Cancer	0.1	0.2	0.5	0.7	0.2	-0.3
Ovarian Cancer	0.2	0.3	0.7	-0.3	0.8	0.2
Prostate Cancer	2.8	3.9	6.5	-1.7	2.5	1.5
Age at First Birth	0.7	1.1	1.4	1.2	-0.9	-1.0
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.5	0.1	0.6
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	-0.3	-0.6
Coronary Artery Disease (CAD)	0.2	0.3	0.4	0.6	-0.5	-0.4
Crohns Disease (2012)	0.0	0.0	0.1	0.1	-0.2	-0.2
Mean Putamen Volume	0.1	0.1	0.3	-0.5	0.4	0.1
Fasting Glucose	1.4	1.7	2.0	1.0	-1.4	-1.4
HbA1C	0.2	0.2	0.4	0.4	-0.3	-0.6
HDL Cholesterol	4.1	6.8	8.6	-2.4	2.4	2.9
LDL Cholesterol	0.2	0.2	0.4	0.6	0.2	-0.6
Lupus	0.0	0.1	0.2	-0.4	0.1	0.2
Neuroticism (2016)	0.1	0.1	0.3	0.3	0.5	0.1
Primary Biliary Cirrhosis	0.5	0.7	0.8	-0.8	0.7	0.9
Rheumatoid Arthritis	0.1	0.1	0.4	-0.1	0.6	0.2
Schizophrenia (2014)	0.0	0.1	0.1	0.3	-0.2	-0.3
Triglycerides	2.0	3.2	4.1	1.9	-1.4	-2.0
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.4	1.5	-1.2	-1.0
Ulcerative Colitis	0.1	0.2	0.3	-0.4	-0.6	0.3
Blood Eosinophil Count	0.5	3.5	5.8	-2.4	1.1	1.9
Blood Platelet Count	0.1	1.5	2.3	-1.1	1.5	1.0
Blood Red Count	3.7	35.4	43.3	-5.1	6.6	6.1
Blood White Count	0.9	6.5	9.1	-1.9	3.0	2.6
Heel T-Score	1.2	9.4	11.7	2.3	-3.4	-3.4
BMI	0.1	0.7	2.0	1.4	-0.1	-0.3
Height	0.1	2.0	4.1	-2.0	-1.0	1.0
Waist Hip Ratio (WHR)	0.0	0.0	0.0	-0.1	-0.1	0.2
Systolic Blood Pressure	0.1	0.5	0.7	0.2	-0.8	-0.8
Smoking Status	0.1	0.2	0.4	-0.6	0.0	0.3
Allergy or Eczema	0.1	0.3	0.7	0.4	-0.8	-0.4
Cardiovascular Disease	0.0	0.1	0.2	0.5	0.3	0.3
Hypothyroidism (self reported)	2.0	4.6	6.4	-1.9	2.5	2.0
Respiratory disease	1.9	4.1	6.5	-1.4	2.6	2.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	-0.6	0.3	0.3
Lung FEV1/FVC ratio	2.4	12.1	13.7	3.2	-3.7	-3.5
Lung FVC	0.6	3.2	5.3	1.3	-2.3	-1.7
Neuroticism	2.0	4.9	6.6	-2.6	1.9	2.1
Chronotype (morning person)	1.2	2.7	4.3	-1.1	2.1	1.6
Hair Pigment	0.3	8.6	11.2	3.3	-2.3	-3.1
Tanning	0.0	0.3	0.5	0.5	-0.7	-0.6
Hand grip strength (left)	0.2	0.6	1.0	-0.8	0.2	1.0
Number of treatments/medications taken	0.1	0.3	0.5	0.7	0.6	0.0
Average weekly spirits intake	1.5	1.8	2.7	-1.3	1.1	1.6
Sensitivity / hurt feelings	0.3	0.6	0.6	-0.7	0.8	0.8
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.0	0.2	0.2
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.2	0.4	0.5
Relative age of first facial hair	0.0	0.1	0.1	0.4	0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	2.6	-1.0	1.6	1.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	0.8	-0.3	-0.6
Ever had hysterectomy (womb removed)	0.3	0.4	1.0	-0.0	1.0	0.3
Systolic blood pressure, automated reading	0.2	0.5	0.7	0.2	-0.9	-0.8
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	2.8	1.4	-1.7	-1.4
Angina	0.2	0.3	0.4	0.6	-0.6	-0.4
Medication for hormone replacement therapy	1.1	1.3	1.5	0.9	-1.2	-1.2
Vitamin and mineral supplements	1.8	2.4	4.0	1.0	-2.0	-1.5
Supplements: Zinc	0.2	0.2	0.3	-0.5	0.6	0.3
Medication: Co-codamol	0.0	0.0	0.1	-0.3	0.2	0.0
Medication: Metformin	0.1	0.1	0.1	0.4	0.1	-0.3
Diabetes (father)	1.5	1.8	3.3	1.8	-0.8	-1.2
Diabetes (mother)	0.9	1.2	1.6	-1.2	1.1	1.0
Severe depression (siblings)	0.8	0.9	1.1	-1.1	0.8	0.9
Pack years adult smoking proportion	2.8	4.3	5.1	-2.3	1.7	2.2
Impedance of leg (right)	0.1	0.5	1.5	-1.2	0.1	0.3
Leg fat-free mass (left)	0.1	0.8	1.2	-0.4	1.0	1.1
Trunk fat percentage	0.1	0.2	0.4	-0.3	0.4	0.7
Hand grip strength (right)	0.1	0.2	0.5	0.1	-0.7	-0.2
Townsend deprivation index at recruitment	1.0	1.4	2.2	0.9	-1.5	-1.1
Current tobacco smoking	0.1	0.1	0.2	0.3	-0.2	-0.5
Average weekly fortified wine intake	0.9	1.0	1.8	1.4	-0.5	-0.9
Maternal smoking around birth	0.5	0.8	1.3	-0.4	0.9	1.1
Fed-up feelings	0.0	0.0	0.1	-0.2	0.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.8	-1.0	1.0	1.4
Relative age voice broke	0.1	0.1	0.2	0.5	-0.2	-0.4
Taking other prescription medications	0.3	0.4	0.6	-0.6	0.6	0.8
Age when periods started (menarche)	0.2	0.5	0.7	0.8	-0.3	-0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	-0.7	0.5	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	5.9	1.1	-2.4	-2.0
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.3	-0.2	0.1
Qualifications: CSEs or equivalent	0.4	0.6	1.4	-1.2	0.3	0.4
Serious illness, injury or assault to yourself	0.3	0.3	0.5	-0.7	0.4	0.6
High blood pressure	0.0	0.1	0.3	0.6	0.0	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	0.3	-0.4	-0.3
Multivitamins +/- minerals	0.5	0.6	1.6	-0.0	1.3	0.5
Stomach or abdominal pain in last month	0.1	0.2	0.2	-0.1	0.5	0.5
Supplements: Glucosamine	0.1	0.2	0.4	0.6	0.4	-0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	0.8	-0.9	-0.5
Medication: Atenolol	0.2	0.3	0.6	0.3	0.8	0.3
Medication: Levothyroxine sodium	0.8	1.4	2.5	-0.9	1.6	0.9
Sitting height	0.3	2.0	4.5	-2.1	0.1	1.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	0.5	-0.3	-0.5
High blood pressure (mother)	0.2	0.2	0.6	-0.1	-0.8	-0.1
Body mass index (BMI)	0.1	0.4	1.1	1.0	-0.1	-0.1
Impedance of leg (left)	0.2	0.7	2.0	-1.4	-0.1	0.4
Leg predicted mass (left)	0.1	0.7	1.1	-0.3	0.9	1.1
Trunk fat mass	0.1	0.3	0.6	-0.3	0.4	0.8
Waist circumference	0.0	0.2	0.4	0.7	0.1	0.2
Number of incorrect matches in round	0.1	0.1	0.2	0.3	0.4	-0.3
Past tobacco smoking	0.7	1.3	1.4	1.2	-1.1	-1.1
Alcohol usually taken with meals	1.9	3.1	4.2	-2.0	1.6	1.7
Nervous feelings	0.1	0.1	0.2	-0.4	-0.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	-0.5	0.3	0.7
Hearing difficulty/problems with background noise	0.3	0.4	0.6	-0.5	0.7	0.8
Hair/balding pattern: Pattern 2	1.4	1.8	2.9	0.8	-1.7	-1.4
Had menopause	0.2	0.3	0.4	-0.3	0.6	0.5
Had other major operations	1.0	1.2	2.2	1.5	-0.5	-1.0
Forced vital capacity (FVC)	0.7	2.5	5.7	0.5	-2.4	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.8	0.6	-2.2	-1.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.0	-1.1	-0.5
Qualifications: None of the above	2.0	4.3	6.2	-2.5	1.5	2.1
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.5	-0.3	0.2
Mouth/teeth dental problems	0.1	0.2	0.4	-0.2	-0.7	-0.2
Heart attack	0.8	1.0	1.6	-0.8	0.9	1.3
Allergy	0.7	1.7	1.9	1.2	-1.3	-1.4
Pain all over the body in last month	3.6	3.9	4.4	-2.1	1.8	2.0
Diabetes (self-reported)	0.3	0.5	0.6	-0.7	0.8	0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.7	-0.2	-0.4
Medication: Ramipril	1.5	1.9	2.1	1.3	-1.4	-1.4
Medication: Simvastatin	1.0	1.5	2.3	-0.8	1.5	1.2
Fluid intelligence score	0.1	0.3	0.5	0.7	0.6	-0.2
Illnesses of siblings	1.0	1.4	1.7	-1.2	1.3	1.1
Neuroticism score	0.8	1.7	1.9	-1.4	1.3	1.2
Weight	0.0	0.2	0.6	-0.1	0.4	0.7
Impedance of arm (right)	0.2	0.9	2.3	-1.5	0.3	0.4
Arm fat percentage (right)	0.0	0.1	0.3	0.5	0.1	0.1
Trunk fat-free mass	0.1	0.7	1.2	-0.6	0.7	1.1
Hip circumference	0.1	0.4	0.6	0.0	0.8	0.7
Time employed in main current job	2.3	2.6	3.5	-1.5	1.9	1.5
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.0	0.4	0.4
Father’s age at death	1.7	2.3	2.7	-1.4	1.5	1.6
Worrier / anxious feelings	9.2	17.5	19.7	-4.4	3.9	4.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.7	-0.9	0.2	0.7
Falls in the last year	0.2	0.2	0.5	0.7	0.0	-0.4
Hair/balding pattern: Pattern 3	1.1	1.7	1.8	1.3	-1.2	-1.4
Number of live births	0.6	0.8	2.1	-0.3	1.4	0.6
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	11.0	1.0	-3.3	-2.0
Pulse rate	4.1	6.9	9.6	2.1	-3.1	-2.6
Happiness	0.5	0.6	0.9	0.7	-0.7	-0.9
Noisy workplace	0.5	0.6	1.1	0.5	-1.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.2	1.1	-1.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.3	1.1	-0.8	-1.1
Mouth/teeth dental problems: Dentures	0.3	0.6	1.0	-0.5	1.0	0.6
Asthma	3.1	6.1	9.0	-1.9	3.0	2.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	0.4	-0.1	-0.3
Medication: Cholesterol lowering	0.2	0.4	0.6	0.8	-0.5	-0.5
Depression (self-reported)	0.1	0.2	0.5	-0.2	-0.7	-0.1
Medication: Lansoprazole	0.4	0.5	1.1	0.4	-1.0	-0.5
Prospective memory result	1.5	1.9	2.5	-1.2	1.6	1.3
Lung cancer (father)	0.8	1.0	2.0	-1.4	0.3	0.9
Illnesses of mother	0.3	0.4	0.7	-0.4	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	9.9	1.1	-3.1	-2.0
Pulse wave Arterial Stiffness index	1.3	1.5	3.2	-1.8	0.3	1.0
Impedance of arm (left)	0.3	1.5	3.5	-1.9	0.7	0.7
Arm fat mass (right)	0.0	0.1	0.2	0.4	0.2	0.4
Trunk predicted mass	0.1	0.9	1.3	-0.7	0.8	1.2
Standing height	0.4	4.4	7.1	-2.7	1.3	2.1
Length of working week for main job	0.1	0.2	0.3	-0.4	-0.6	-0.0
Exposure to tobacco smoke at home	0.8	0.9	1.5	-0.6	1.2	0.9
Breastfed as a baby	0.1	0.1	0.2	-0.0	-0.5	-0.3
Tense / ‘highly strung’	0.1	0.2	0.5	-0.7	0.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.1	-1.0	-0.3	0.4
Hair/balding pattern: Pattern 4	2.0	4.7	5.7	-2.2	1.9	2.4
Birth weight of first child	0.2	0.4	0.8	-0.9	-0.5	0.3
Peak expiratory flow (PEF)	2.5	5.9	10.8	1.4	-3.3	-2.2
Pulse wave reflection index	6.1	7.5	8.9	-3.0	2.5	2.7
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.1	-0.0	-0.1
Loud music exposure frequency	0.2	0.2	0.2	-0.5	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.2	0.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	0.9	-0.4	-0.5
Blood clot in the leg (DVT)	0.0	0.1	0.1	-0.0	0.4	0.1
Medication: Paracetamol	0.0	0.1	0.1	-0.1	0.3	0.2
Headache pain in last month	0.5	0.9	1.1	-1.0	0.8	1.1
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	3.4	-1.9	1.3	1.6
Glaucoma (self-reported)	0.1	0.1	0.1	-0.1	0.3	0.3
Gout (self-reported)	1.5	2.0	2.3	1.5	-1.4	-1.4
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	7.0	-2.1	2.6	2.2
Medication: Amlodipine	0.7	0.9	1.7	1.3	-0.6	-0.8
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.1	0.5	0.2
Birth weight	0.0	0.1	0.2	-0.5	0.1	-0.0
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.2	0.2	0.2
High blood pressure (siblings)	0.6	0.9	1.1	0.8	-1.1	-0.9
Forced vital capacity (FVC), Best measure	0.6	2.3	5.2	0.5	-2.3	-1.3
Body fat percentage	0.0	0.0	0.1	0.2	0.1	0.3
Leg fat percentage (right)	0.0	0.1	0.2	0.4	0.2	0.3
Arm fat-free mass (right)	0.2	0.8	1.4	-0.6	0.7	1.2
Exposure to tobacco smoke outside home	1.0	1.4	2.3	1.5	-0.9	-1.1
Comparative body size at age 10	0.2	0.4	0.9	1.0	-0.5	-0.3
Number of full brothers	0.3	0.4	0.5	-0.6	0.7	0.5
Worry too long after embarrassment	3.4	5.8	7.7	-2.8	2.0	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	0.1	-1.1	-0.5
Wheeze or whistling in the chest in last year	0.7	1.2	1.8	-0.8	1.3	1.1
Number of children fathered	1.2	1.4	1.5	1.1	-1.2	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.3	-0.1	0.1
Age at first live birth	1.4	2.5	3.4	1.3	-1.8	-1.5
Pulse wave peak to peak time	1.1	1.3	2.9	1.7	-0.3	-1.0
Health satisfaction	1.5	1.9	2.7	1.1	-1.6	-1.4
Shortness of breath walking on level ground	0.0	0.0	0.0	0.0	-0.1	-0.1
Qualifications: College or University degree	1.2	3.8	4.2	2.0	-1.7	-2.0
Eye problems/disorders: None of the above	1.0	1.1	1.8	0.9	-0.8	-1.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.8	0.9	-0.6	-0.7
Emphysema/chronic bronchitis	2.1	2.4	2.5	-1.6	1.5	1.5
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	-0.0	-0.1	0.0
Neck or shoulder pain in last month	0.1	0.1	0.1	-0.2	-0.2	0.4
Medication: Blood pressure	2.4	4.2	5.7	2.4	-1.7	-2.0
Angina (self-reported)	0.5	0.7	1.0	1.0	-0.8	-0.7
Migraine (self-reported)	0.0	0.0	0.0	-0.1	0.0	-0.0
Medication: Ibuprofen	0.4	0.5	0.6	0.8	-0.6	-0.8
Medication: Allopurinol	0.0	0.1	0.1	0.3	-0.3	-0.2
Medication: Omeprazole	0.8	1.0	1.1	-0.9	1.0	1.0
Medication: Seretide 50 evohaler	1.2	1.4	3.4	-0.5	1.8	0.7
Mean time to correctly identify matches	0.0	0.1	0.1	-0.2	0.3	0.4
Heart disease (mother)	1.2	1.4	2.4	0.7	-1.5	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.6	0.2	0.5
Whole body fat mass	0.0	0.1	0.2	0.4	-0.1	0.2
Leg fat mass (right)	0.0	0.1	0.2	0.5	0.2	0.4
Arm predicted mass (right)	0.2	0.9	1.6	-0.6	0.9	1.3
Pulse rate, automated reading	1.5	4.8	7.3	1.5	-2.7	-2.2
Alcohol intake frequency.	0.7	1.7	2.0	-1.2	1.3	1.4
Comparative height size at age 10	0.1	0.5	1.0	-0.7	-1.0	0.1
Number of full sisters	0.0	0.0	0.0	0.1	-0.2	-0.2
Suffer from ‘nerves’	0.0	0.1	0.1	0.3	-0.3	-0.1
Overall health rating	0.0	0.0	0.0	0.2	0.2	0.1
Chest pain or discomfort	0.0	0.0	0.1	0.4	-0.0	0.0
Had major operations	0.8	0.9	1.6	-1.3	0.2	1.0
Age at last live birth	0.0	0.0	0.1	0.3	-0.1	0.0
Family relationship satisfaction	1.7	2.0	3.5	-1.9	0.9	1.4
Leg pain on walking	2.7	3.4	3.7	1.9	-1.8	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.8	0.3	-1.3	-0.6
Commuting to job workplace: Car/motor vehicle	11.7	13.4	15.7	-4.0	3.0	3.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.2	-0.6	-0.4
Medication: Aspirin	0.8	1.0	1.6	1.3	-0.7	-0.9
Supplements: Vitamin C	0.7	0.8	0.9	-0.9	0.9	0.9
Knee pain experienced in last month	1.2	1.9	2.6	-1.0	1.6	1.4
Hypertension (Self-reported)	0.0	0.1	0.2	0.4	0.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-1.0	-0.3	0.5
Illnesses of father: Heart disease	0.2	0.3	0.5	0.7	-0.2	-0.6
Illnesses of siblings: Diabetes	0.6	0.7	1.0	-1.0	0.7	0.8
Smoking status: Previous	1.5	2.3	2.5	-1.6	1.4	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.1	-1.1	-0.5	0.4
Whole body fat-free mass	0.2	0.9	1.4	-0.6	0.9	1.2
Leg fat-free mass (right)	0.1	0.6	1.0	-0.4	0.7	1.0
Arm fat percentage (left)	0.0	0.1	0.1	0.3	0.3	0.3
Average weekly red wine intake	0.1	0.2	0.5	-0.7	-0.2	0.0
Handedness (chirality/laterality): Left-handed	1.7	2.0	2.9	1.7	-0.8	-1.5
Mood swings	0.3	0.5	0.5	-0.7	0.7	0.7
Loneliness, isolation	0.1	0.2	0.2	0.4	-0.5	-0.4
Long-standing illness, disability or infirmity	0.0	0.1	0.1	0.1	0.3	0.3
Ever had bowel cancer screening	0.3	0.4	0.8	0.9	0.2	-0.6
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.3	0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.4	1.2	-0.4	-0.5
Friendships satisfaction	2.1	2.6	3.5	-1.9	1.3	1.6
Qualifications: nursing, teaching	0.6	0.9	1.9	1.4	-0.5	-0.8
Commuting to job workplace: Walk	0.3	0.4	0.5	0.7	-0.1	-0.7
Eye problems/disorders: Cataract	0.3	0.3	0.6	-0.4	0.2	0.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.4	0.1	0.3
Medication for cholesterol	0.4	0.6	0.9	0.6	-1.0	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	1.6	1.0	-1.2	-1.2
Back pain experienced in last month	0.2	0.3	0.5	-0.7	0.4	0.5
Mineral and other dietary supplements	1.9	2.6	5.5	-2.3	0.5	1.4
Breast cancer (self-reported)	0.2	0.3	0.5	-0.3	0.5	0.7
Asthma (self-reported)	2.7	5.3	8.0	-1.7	2.8	2.2
Osteoporosis (self-reported)	0.0	0.1	0.1	0.4	0.2	0.1
Osteoarthritis (self-reported)	0.2	0.3	0.4	-0.6	0.6	0.5
Medication: Aspirin	0.7	0.9	1.2	1.1	-0.8	-0.8
Medication: Gliclazide	1.5	1.7	2.5	1.0	-1.6	-1.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.3	-0.5	0.4	0.3
Smoking status: Current	0.4	0.6	0.8	0.8	-0.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.6	10.6	1.2	-3.3	-2.2
Whole body water mass	0.1	0.8	1.3	-0.6	0.9	1.2
Leg predicted mass (right)	0.1	0.6	1.0	-0.4	0.7	1.0
Arm fat mass (left)	0.1	0.2	0.4	0.1	0.5	0.6
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	-0.1	-0.0	0.2
Average weekly champagne plus white wine intake	0.4	0.5	0.9	-0.5	0.9	0.6
Miserableness	0.0	0.0	0.1	0.3	0.2	-0.1
Guilty feelings	0.3	0.5	0.8	-0.6	0.9	0.6
Wears glasses or contact lenses	1.1	1.2	2.3	1.5	-0.4	-1.1
Ever taken oral contraceptive pill	1.1	1.2	1.8	-1.4	0.8	1.0
Hearing aid user	0.6	0.7	0.8	-0.8	0.9	0.9
Mother’s age at death	0.3	0.4	1.1	-0.0	1.0	0.3
Financial situation satisfaction	0.1	0.2	0.2	-0.5	-0.4	0.4
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.5	-2.1	0.1	1.3
Commuting to job workplace: Public transport	4.9	5.8	6.5	2.5	-2.2	-2.5
Eye problems/disorders: Glaucoma	1.8	2.2	2.5	-1.3	1.6	1.5
Medication: Blood pressure	1.8	3.4	3.7	-1.9	1.7	1.9
Pain type(s) experienced in last month: Hip pain	0.9	1.1	1.3	-1.1	1.0	1.1
Supplements: Fish oil (including cod liver oil)	3.3	4.3	6.1	2.5	-1.5	-2.1
High cholesterol (Self-reported)	0.3	0.6	1.1	-0.4	1.1	0.7
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.0	-0.0	-0.2
Medication: Paracetamol	0.0	0.1	0.2	0.1	0.4	0.2
Medication: Lisinopril	0.1	0.1	0.2	-0.3	0.3	0.4
Medication: Atorvastatin	0.0	0.1	0.2	0.0	-0.4	-0.0
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.5	0.1	0.6
Alcohol drinker status: Never	1.6	1.9	2.2	-1.3	1.3	1.5
Ever smoked	0.1	0.3	0.3	-0.5	0.5	0.5
Basal metabolic rate	0.1	0.6	1.1	-0.4	0.7	1.1
Leg fat percentage (left)	0.0	0.1	0.2	0.1	0.2	0.5
Arm fat-free mass (left)	0.1	0.4	0.9	-0.1	0.5	0.9
Number of operations (self-reported)	0.2	0.3	0.4	-0.4	0.5	0.7
Average weekly beer plus cider intake	1.7	2.5	3.2	1.4	-1.8	-1.6
Irritability	0.2	0.3	0.4	-0.6	0.2	0.7
Risk taking	1.7	2.5	3.5	1.3	-1.9	-1.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.2	0.5	0.5	-0.2
Fractured/broken bones in last 5 years	0.4	0.5	0.8	-0.9	0.2	0.8
Age started oral contraceptive pill	0.4	0.5	0.6	-0.6	0.8	0.6
Diastolic blood pressure, automated reading	0.1	0.4	1.0	-0.3	-1.0	-0.3
Ever depressed for a whole week	0.0	0.0	0.0	-0.1	-0.2	-0.1
Unable to work because of sickness or disability	0.4	0.5	0.7	-0.7	0.6	0.8
Commuting to job workplace: Cycle	2.3	2.8	3.5	1.9	-1.5	-1.6
Myopia	3.0	4.4	4.5	2.1	-2.1	-2.0
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.8	-0.1	0.3
Cholesterol lowering medication	3.6	5.3	7.6	-1.9	2.8	2.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	1.5	-1.0	1.2	1.2
Pain experienced in last month	2.0	3.4	3.9	2.0	-1.6	-1.9
Supplements: Calcium	0.3	0.3	0.8	-0.1	0.9	0.4
Basal cell carcinoma (self-reported)	1.3	1.5	2.1	1.5	-0.8	-1.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.1	-0.7	0.6	1.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.0	0.4	0.2
Heart disease (siblings)	0.4	0.5	0.9	0.9	0.1	-0.8
Alcohol drinker status: Previous	0.0	0.0	0.1	0.1	-0.3	0.0
Pack years of smoking	2.9	4.2	4.9	-2.2	1.7	2.2
Impedance of whole body	0.4	1.9	4.2	-2.1	0.6	1.0
Leg fat mass (left)	0.0	0.1	0.2	0.3	0.2	0.5
Arm predicted mass (left)	0.1	0.6	1.1	-0.3	0.7	1.1