Hub : Genes

SCP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.0250	6.5e-06	0.046	0.034	0.023	0.037	0.030	2.4e-06	4.5e-05	6.7e-04	2.3e-05	1.1e-04
2	GTEx	Cells EBV-transformed lymphocytes	0.3800	0.0960	1.7e-05	0.253	NA	0.236	NA	0.219	8.3e-09	NA	2.8e-08	NA	1.0e-07
3	GTEx	Cells Transformed fibroblasts	0.2070	0.0600	8.8e-04	0.017	NA	0.104	NA	0.036	1.8e-02	NA	3.4e-08	NA	1.1e-03
4	GTEx	Whole Blood	0.0620	0.0250	2.4e-03	0.014	NA	-0.002	NA	0.003	1.6e-02	NA	6.0e-01	NA	1.4e-01
5	METSIM	Adipose	0.0438	0.0172	5.5e-04	0.002	0.029	0.016	0.028	0.006	1.4e-01	3.4e-05	1.7e-03	4.1e-05	3.2e-02
6	NTR	Blood	0.0400	0.0106	4.4e-08	0.009	0.021	0.024	0.026	0.025	3.4e-04	1.3e-07	2.0e-08	8.3e-09	1.3e-08
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.0620	0.0340	4.4e-03	0.020	0.030	0.049	NA	0.040	1.5e-02	3.8e-03	3.1e-04	NA	1.0e-03
8	TCGA	Pancreatic Adenocarcinoma	0.1480	0.0710	8.5e-04	0.005	0.027	0.018	NA	0.010	2.0e-01	2.5e-02	5.9e-02	NA	1.2e-01
9	TCGA	Testicular Germ Cell Tumors	0.1440	0.0730	8.3e-03	0.012	0.065	0.085	NA	0.059	1.2e-01	2.6e-03	6.3e-04	NA	4.0e-03
10	TCGA	Thyroid Carcinoma	0.0580	0.0270	4.0e-05	0.031	0.025	0.044	NA	0.032	5.0e-04	1.5e-03	3.5e-05	NA	4.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.8	1.2	4.4	0.4	0.5	-0.3	0.4	1.0	1.2	-1.2	-1.7	0.4	2.1
Bipolar Disorder or Schizophrenia	0.5	1.2	4.0	-0.1	0.3	1.4	0.0	1.4	0.3	-2.0	-1.7	0.1	1.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.1	0.2	0.5	0.5	0.4	-0.7	0.1	0.8	0.3	-0.0
Depression (Nagel 2018)	0.5	0.7	2.7	-0.7	-1.0	-0.2	-0.3	1.3	-1.6	-1.0	-0.3	-0.0	-0.5
Intelligence (Savage-Jansen 2018)	0.8	2.4	6.8	-2.3	-1.8	-0.5	-1.2	-0.9	-2.6	-1.1	-0.2	0.4	-2.1
Neuroticism (Nagel 2018)	0.1	0.3	1.0	-0.1	0.3	-0.0	0.6	1.0	-0.9	-1.0	-0.2	0.3	0.2
Schizophrenia (2018)	0.4	0.8	3.8	-0.4	-0.1	2.0	-0.2	0.9	-0.6	-1.1	-0.9	-0.3	-0.4
Schizophrenia vs Biploar Disorder	0.5	0.7	1.8	0.3	1.3	-0.9	0.6	0.7	1.3	0.5	-0.2	0.6	0.9
Worry (Nagel 2018)	0.3	0.6	1.9	-0.5	-0.3	-0.6	-0.2	1.4	-0.4	-1.0	-1.1	-0.2	0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	-0.6	-0.5	1.3	-0.8	0.7	-1.2	0.2	0.9	-0.2	0.2
Alzheimer’s Disease (in father)	0.7	0.7	1.7	1.1	1.3	-0.5	0.9	-1.1	-0.2	-0.3	0.4	-0.5	-1.3
Alzheimer’s Disease (including proxy)	0.4	0.5	2.5	0.6	0.7	1.6	0.1	0.0	-0.7	0.2	1.0	0.1	-0.4
Crohns Disease (2017)	0.5	1.0	3.6	0.0	-0.8	1.9	-0.4	1.8	-0.3	0.4	0.6	-1.1	0.6
Irritable Bowel Disease (IBD)	0.8	2.0	5.9	-0.8	-1.6	1.1	-1.2	2.4	-0.7	-0.9	-0.5	-2.3	1.2
Ulcerative Colitis (UC)	1.9	3.5	8.0	-1.8	-2.3	0.4	-2.2	1.8	-1.2	-2.2	-1.4	-2.8	1.4
Major Depression (MDD)	1.1	1.4	3.1	-0.7	-1.4	-1.5	-1.1	0.7	-1.6	-0.1	1.1	-1.8	-0.5
Reaction Time	0.6	1.2	2.8	-1.1	-0.7	-1.6	-0.4	-1.3	-1.6	-0.4	-0.4	-0.0	-1.7
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.1	-1.6	-0.8	0.5	-0.5	-0.7	-1.8	-1.7	-1.1	1.1	-1.3
Breast Cancer	0.2	0.4	0.9	0.4	0.7	-0.0	0.7	-1.0	-0.2	-0.7	0.9	0.4	0.1
Ovarian Cancer	1.4	1.8	6.2	2.5	1.6	0.7	1.0	0.6	2.1	0.6	0.2	-0.1	1.6
Prostate Cancer	3.2	4.5	13.7	2.7	3.7	1.8	2.7	1.6	2.4	1.4	1.3	1.3	0.9
Age at First Birth	0.2	0.2	0.8	-0.2	-0.4	0.2	-0.4	0.8	-0.0	0.2	0.6	-0.1	0.9
Bipolar Disorder (2011)	1.8	1.7	4.4	-1.3	-1.9	0.5	-1.0	0.6	-0.7	-1.4	-2.1	-1.1	1.4
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	-0.0	0.0	0.5	0.4	0.7	0.1	-0.6	-0.1	0.6	0.5
Coronary Artery Disease (CAD)	1.2	1.5	5.8	0.8	0.6	1.0	-0.3	2.4	1.3	-0.5	-0.4	0.9	1.9
Crohns Disease (2012)	0.5	0.8	2.6	0.1	-0.6	1.6	-0.4	1.6	-0.2	0.4	0.3	-1.1	0.9
Mean Putamen Volume	0.3	0.3	1.5	-0.4	0.2	-0.6	0.0	0.2	0.2	-0.7	-1.2	0.4	0.4
Fasting Glucose	1.0	1.2	5.1	0.4	0.1	1.4	-0.6	0.9	1.3	2.3	0.8	-0.7	1.0
HbA1C	0.3	0.3	0.9	0.1	0.2	0.8	0.4	0.4	-0.5	0.3	0.5	0.9	-0.6
HDL Cholesterol	0.7	1.2	4.6	1.2	1.6	0.9	2.2	1.5	-0.1	-0.5	0.0	0.6	-0.1
LDL Cholesterol	0.3	0.4	1.5	-0.5	-0.3	-0.9	0.1	-0.9	0.2	-0.4	-1.2	-0.0	-0.6
Lupus	0.6	1.0	2.8	-0.5	-1.7	-1.4	-0.7	1.4	-1.1	-0.7	-0.4	0.0	0.7
Neuroticism (2016)	0.2	0.3	1.0	0.2	0.8	-0.4	0.8	0.1	-0.2	-1.0	0.2	0.5	0.5
Primary Biliary Cirrhosis	0.8	1.2	3.4	0.7	-0.4	1.2	0.2	1.9	1.0	-0.7	-1.2	-0.1	1.8
Rheumatoid Arthritis	0.6	0.9	2.2	1.2	0.8	1.0	0.4	1.1	1.1	0.2	0.3	-0.6	1.5
Schizophrenia (2014)	0.4	0.8	3.9	-0.1	0.0	2.0	-0.1	1.2	-0.4	-1.3	-0.6	0.4	0.6
Triglycerides	1.1	1.7	13.1	-0.7	-0.7	-3.6	-0.7	0.2	0.6	1.5	0.4	-0.0	-0.2
Type 2 Diabetes (T2D) (2012)	2.6	3.0	8.3	-2.5	-2.9	-1.3	-1.6	-0.1	-2.6	-1.4	-0.4	-1.0	-0.9
Ulcerative Colitis	1.0	1.4	5.3	-0.6	-1.0	0.9	-0.8	1.4	-0.0	-1.4	-1.1	-2.3	1.0
Blood Eosinophil Count	0.2	1.2	3.8	1.4	0.7	1.4	0.3	0.4	-0.0	-1.9	-1.1	1.4	0.6
Blood Platelet Count	0.5	5.5	14.3	3.3	3.8	1.8	2.8	2.5	2.0	0.4	1.3	2.5	1.0
Blood Red Count	2.1	20.4	55.4	6.6	6.8	-1.3	7.4	0.5	0.9	1.0	3.5	6.4	-1.5
Blood White Count	0.7	5.1	13.3	3.5	3.1	0.6	3.6	0.9	0.3	0.8	2.5	2.6	-0.5
Heel T-Score	0.4	2.9	14.5	-2.6	-1.8	-1.2	-3.8	0.4	-1.2	0.1	-0.2	-1.2	-0.4
BMI	0.2	1.2	3.6	-0.7	0.1	0.8	0.6	-1.1	-1.9	-1.8	-0.1	0.4	-1.6
Height	1.1	20.8	59.1	-6.0	-6.2	-0.0	-4.2	-4.0	-0.6	-4.3	-7.7	-4.5	1.1
Waist Hip Ratio (WHR)	0.1	0.6	1.3	0.9	-0.0	-1.1	0.1	0.4	0.6	-0.8	-1.1	-1.1	0.8
Systolic Blood Pressure	0.2	0.8	4.0	-0.9	-0.7	0.2	-0.9	-2.0	0.8	0.9	-0.6	-0.3	0.2
Smoking Status	0.4	0.9	3.2	0.6	0.7	1.8	0.1	-0.5	-0.1	1.6	1.2	0.7	-0.3
Allergy or Eczema	0.2	0.7	1.9	-0.5	-1.4	-0.7	-1.1	1.0	-0.7	0.7	-0.3	-0.8	0.2
Cardiovascular Disease	0.5	1.5	4.9	-0.0	0.3	-0.5	0.6	-1.4	-1.1	1.5	2.2	-0.9	-1.9
Hypothyroidism (self reported)	2.0	4.5	12.2	2.7	2.6	0.4	2.0	3.5	2.5	0.3	-1.0	1.3	2.3
Respiratory disease	1.3	2.9	7.7	2.3	2.7	-0.0	2.8	0.6	-0.3	0.3	1.5	1.9	-1.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.9	-0.7	-0.8	0.7	-0.8	0.1	0.2	-0.3	-0.5	-2.0	0.2
Lung FEV1/FVC ratio	1.0	5.1	14.0	-3.4	-3.3	0.9	-3.7	-2.0	-1.4	-0.7	-1.5	-2.1	-1.1
Lung FVC	0.3	1.4	3.1	-1.3	-0.5	-0.5	-1.5	-1.2	0.3	-1.7	-1.8	-0.0	1.3
Neuroticism	0.1	0.3	2.2	0.3	-0.1	-0.2	0.6	1.5	-0.8	-0.4	0.0	-0.0	-0.0
Chronotype (morning person)	0.8	2.0	7.7	1.6	2.8	-0.1	2.4	0.5	0.9	-0.3	-0.3	1.6	-0.0
Hair Pigment	0.0	0.6	1.2	-0.2	0.3	0.5	-1.0	1.0	-0.0	0.8	0.7	1.1	0.9
Tanning	0.1	1.5	4.6	-1.2	-1.1	0.1	-1.0	-1.1	0.5	-1.6	-2.1	-1.6	0.5
Hand grip strength (left)	0.4	1.1	4.6	-0.4	0.4	0.7	0.3	-2.1	1.2	-1.1	-0.7	0.7	1.2
Number of treatments/medications taken	0.4	0.7	2.6	-0.1	-0.1	1.6	0.5	1.1	0.9	0.6	-0.1	-0.4	1.2
Average weekly spirits intake	0.4	0.6	1.9	-0.3	-0.4	-0.6	0.3	-0.9	-1.2	-1.4	0.3	-0.2	-0.8
Sensitivity / hurt feelings	0.4	0.6	2.6	-0.6	-0.0	-1.1	0.3	0.3	-1.6	-1.0	-0.3	0.9	-0.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.1	-1.8	-1.0	-0.8	-0.7	0.8	-1.4	-1.5	-0.8	-0.1	-0.5
Hearing difficulty/problems: Yes	0.5	0.8	1.9	1.1	0.4	1.3	0.8	-0.4	-0.9	-0.1	1.2	1.4	-0.6
Relative age of first facial hair	0.1	0.2	0.9	0.1	0.9	-0.3	0.6	0.2	-0.1	-0.7	-0.0	0.5	-0.1
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.8	-1.3	-0.1	1.3	0.9	0.7	-1.7	-0.2	-0.2	0.4	-1.4
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.5	-0.3	-0.8	-1.6	-0.3	0.3	-1.4	0.6	0.3	1.2	-0.9
Ever had hysterectomy (womb removed)	0.4	0.5	1.7	-0.1	0.7	-0.4	1.1	0.6	0.5	-0.2	-0.3	1.3	-0.6
Systolic blood pressure, automated reading	0.4	1.1	4.5	-1.2	-0.9	0.6	-1.0	-2.1	0.3	-0.4	-1.4	0.7	-0.1
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	6.6	-2.5	-2.1	-1.5	-2.0	-1.0	-0.8	0.1	-0.5	-2.6	-0.5
Angina	0.8	1.0	2.7	-0.9	-1.2	1.0	-0.9	0.6	-0.2	-1.6	-1.4	0.1	0.9
Medication for hormone replacement therapy	0.5	0.5	1.5	-0.7	-0.4	-0.9	-1.2	0.2	-0.3	-0.4	-0.7	-1.2	0.1
Vitamin and mineral supplements	1.2	1.6	4.2	-0.6	-1.3	-1.5	-2.0	-0.7	-0.0	-1.1	-1.3	-2.0	0.6
Supplements: Zinc	0.3	0.3	1.1	-0.4	-0.2	-0.6	0.4	-0.5	-0.7	-0.6	-0.5	1.0	-0.3
Medication: Co-codamol	0.3	0.3	0.7	0.4	-0.5	-0.2	-0.3	0.6	0.4	0.8	-0.2	0.8	0.8
Medication: Metformin	0.5	0.6	2.1	-1.4	-0.5	-1.2	-0.5	-0.1	0.2	1.2	-0.5	-0.7	-0.3
Diabetes (father)	0.7	0.9	2.9	-0.6	-0.9	1.0	-0.6	-1.7	-0.7	0.4	-0.5	-0.9	-1.2
Diabetes (mother)	0.6	0.7	3.2	0.3	-0.1	-0.8	0.3	1.8	1.0	-0.2	-0.9	-0.2	1.2
Severe depression (siblings)	0.3	0.3	1.4	-1.2	-0.3	0.6	-0.4	0.7	-0.2	-0.8	-0.4	-0.1	-0.5
Pack years adult smoking proportion	0.5	0.8	1.6	0.4	0.6	0.8	1.2	-0.4	0.3	1.1	1.0	-0.8	-1.3
Impedance of leg (right)	0.6	3.1	6.7	2.1	1.8	-1.9	0.3	2.0	2.5	0.8	-0.0	1.3	2.6
Leg fat-free mass (left)	0.6	3.3	6.2	-2.4	-2.0	0.1	0.1	-2.5	-2.0	-1.4	-1.4	-1.6	-2.4
Trunk fat percentage	0.9	3.7	12.6	-2.0	-2.1	-0.5	-0.6	-2.3	-3.5	-1.5	-0.1	-1.0	-2.7
Hand grip strength (right)	0.4	1.0	6.7	-1.1	-0.2	0.5	-0.5	-2.6	0.5	-0.8	-0.8	0.2	0.5
Townsend deprivation index at recruitment	1.0	1.4	3.7	-1.9	-1.3	-0.4	-1.6	-1.6	-1.3	0.1	-0.7	-0.6	-0.9
Current tobacco smoking	0.4	0.6	2.5	0.1	-0.7	1.2	-0.3	-1.1	-0.1	1.6	0.3	0.4	-0.4
Average weekly fortified wine intake	0.4	0.4	1.5	-0.2	-0.2	0.9	-0.1	-0.2	-0.9	0.1	0.9	-0.5	-1.2
Maternal smoking around birth	0.4	0.6	4.8	-0.2	-0.6	0.0	0.7	-2.2	-0.5	-0.1	-0.3	0.0	-0.6
Fed-up feelings	0.5	0.9	4.6	-1.0	-0.3	-2.1	-0.2	0.7	-0.2	-0.9	-1.1	0.4	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.8	0.6	0.9	1.0	0.9	0.7	-1.3	0.1	1.1	1.3	-1.4
Relative age voice broke	1.3	2.0	5.3	1.2	1.4	-1.7	1.0	2.3	1.2	-1.2	-0.8	0.6	1.9
Taking other prescription medications	0.5	0.8	2.5	-1.1	-1.1	-0.1	-0.3	1.6	-0.1	0.1	-1.0	-0.4	1.1
Age when periods started (menarche)	0.6	1.4	5.8	-0.6	0.2	-2.4	-0.1	0.8	1.8	0.7	-0.5	-1.1	1.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	5.8	-1.3	-1.1	-2.4	-0.0	-1.2	-2.0	-0.7	0.3	0.0	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	7.8	-2.3	-1.8	-0.6	-2.8	-1.0	-1.5	0.5	0.0	-2.0	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.9	-0.8	0.5	1.7	0.1	-1.1	0.4	0.3	-0.5	-0.7	-0.7
Qualifications: CSEs or equivalent	0.6	0.8	3.1	0.5	1.1	-0.5	-0.1	0.6	1.5	0.2	-1.0	0.3	1.8
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-0.8	-0.7	0.6	-0.2	-0.5	-0.0	0.8	-1.0	0.4	-0.5
High blood pressure	0.5	1.4	5.7	0.1	-0.1	0.9	0.4	-1.5	-0.7	1.6	2.4	-0.1	-1.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	-0.5	-1.2	-1.2	-0.7	0.8	-1.0	0.6	0.3	-0.7	-0.4
Multivitamins +/- minerals	1.4	1.7	4.4	0.9	1.5	1.1	1.5	1.2	1.0	1.6	1.2	2.1	0.5
Stomach or abdominal pain in last month	1.5	1.8	5.7	1.1	1.9	-0.8	1.1	0.6	0.8	2.4	2.1	0.3	-0.5
Supplements: Glucosamine	0.5	0.6	3.2	-0.6	0.6	0.7	0.7	-0.6	0.7	-0.0	-0.3	1.8	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.6	-0.2	-0.2	0.4	-0.2	-0.2	-1.6	-0.4	1.0	0.3	-1.1
Medication: Atenolol	1.3	1.7	8.7	0.6	0.9	2.9	1.0	0.6	-0.3	1.1	1.4	1.4	-0.5
Medication: Levothyroxine sodium	1.6	2.7	10.4	1.9	1.5	-0.1	1.2	3.2	2.0	1.6	0.2	0.4	1.6
Sitting height	0.5	3.5	10.6	-2.1	-2.1	0.6	-1.3	-2.2	0.4	-1.1	-2.8	-3.2	-0.1
Chronic bronchitis/emphysema (father)	0.9	1.0	2.5	1.1	0.4	0.9	0.0	1.1	1.2	0.7	-0.8	1.4	1.6
High blood pressure (mother)	0.5	0.7	2.1	-1.5	-1.2	0.5	-1.0	-0.4	0.2	-0.5	-1.2	-0.6	0.3
Body mass index (BMI)	0.6	2.5	8.5	-1.5	-1.1	0.5	-0.0	-2.1	-2.9	-0.7	0.6	-0.4	-2.7
Impedance of leg (left)	0.3	1.5	4.2	1.0	1.1	-1.9	-0.2	1.4	1.6	0.4	-0.1	0.6	2.0
Leg predicted mass (left)	0.6	3.4	6.5	-2.5	-2.1	0.1	0.1	-2.5	-2.1	-1.4	-1.4	-1.6	-2.5
Trunk fat mass	1.1	4.6	11.7	-2.5	-2.5	-0.3	-0.7	-2.7	-3.4	-1.6	-0.6	-1.5	-2.9
Waist circumference	1.0	3.5	8.5	-2.3	-2.3	-0.2	-0.6	-2.4	-2.9	-1.1	-0.5	-1.3	-2.6
Number of incorrect matches in round	0.6	1.0	4.3	-0.2	1.5	-0.1	0.6	1.0	-0.9	0.6	0.5	2.1	-0.6
Past tobacco smoking	0.4	0.7	2.3	-0.4	-0.9	-1.5	-0.8	0.7	0.4	-0.7	-0.6	-0.3	1.0
Alcohol usually taken with meals	0.6	0.9	2.6	0.4	0.7	-1.6	1.1	1.4	-0.3	0.4	-0.2	1.3	-0.9
Nervous feelings	0.5	0.9	3.8	-0.1	-1.0	-0.9	-0.6	-0.0	-1.4	-2.0	-0.3	0.1	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.0	-1.1	-0.4	1.4	-0.0	0.3	-1.1	0.0	0.0	0.7	-0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.5	0.5	0.2	-0.6	0.7	-0.1	-0.8	0.6	0.7	1.2	-0.7
Hair/balding pattern: Pattern 2	1.0	1.3	4.3	-1.2	-1.0	-0.2	-2.1	-1.1	0.6	-0.0	-1.1	-1.5	0.8
Had menopause	0.3	0.4	1.4	0.4	0.0	-0.5	0.4	-0.1	-0.8	-0.8	-0.6	1.2	-0.3
Had other major operations	1.0	1.2	2.3	-1.4	-1.4	-0.4	-0.5	-0.1	-1.4	1.2	1.1	-0.8	-1.5
Forced vital capacity (FVC)	1.2	4.5	12.5	-1.8	-2.0	-0.5	-2.6	-1.6	0.8	-2.6	-3.5	-2.1	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	8.3	-2.1	-1.7	-0.5	-2.9	-0.3	-0.4	0.9	-0.8	-2.2	0.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.3	-1.3	-1.1	0.5	-1.3	-0.2	0.3	-1.3	-1.4	-1.5	1.2
Qualifications: None of the above	0.5	1.1	4.4	2.1	0.9	-1.0	1.4	-0.2	-0.5	-0.6	0.9	0.4	-0.9
Financial difficulties in last 2 years	1.4	1.8	6.2	-1.8	-0.3	1.3	-0.8	0.7	0.0	-2.3	-2.5	-0.6	0.6
Mouth/teeth dental problems	0.1	0.2	0.6	0.0	0.2	-0.8	-0.7	-0.4	0.1	-0.2	-0.2	-0.2	-0.1
Heart attack	1.3	1.6	4.0	1.5	0.3	2.0	1.4	-0.7	-0.9	1.0	1.5	1.6	-0.8
Allergy	0.4	0.9	2.6	-0.4	0.2	0.6	-0.7	-0.0	1.3	-1.0	-1.6	0.1	1.6
Pain all over the body in last month	0.8	0.9	3.2	-0.5	-0.7	0.5	0.4	0.2	-1.8	-0.9	-1.3	0.8	-1.0
Diabetes (self-reported)	0.1	0.2	0.5	-0.5	-0.5	-0.7	0.0	0.3	0.2	-0.2	-0.3	-0.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.2	-0.3	-0.2	-1.5	-0.0	0.3	-1.2	0.3	0.8	0.1	-0.5
Medication: Ramipril	0.4	0.5	1.7	-0.8	-0.7	-0.3	-1.3	0.4	0.2	0.0	0.5	-0.8	0.7
Medication: Simvastatin	1.0	1.4	3.2	1.5	0.9	0.3	1.3	1.8	1.1	0.2	0.6	1.3	1.7
Fluid intelligence score	0.1	0.3	1.0	0.5	1.0	-0.1	0.8	-0.1	0.5	-0.5	-0.1	0.5	-0.1
Illnesses of siblings	0.5	0.7	2.0	0.7	0.9	-0.2	1.0	-0.3	0.9	1.4	0.4	1.0	0.2
Neuroticism score	0.2	0.5	2.2	0.1	0.3	-0.5	0.6	1.5	-0.1	-0.9	-0.5	-0.3	1.0
Weight	0.9	4.2	8.6	-2.7	-2.4	-0.0	-0.5	-2.9	-2.7	-1.2	-1.1	-1.5	-2.7
Impedance of arm (right)	0.1	0.7	2.7	0.8	-0.7	-1.6	-0.7	0.2	0.1	-0.7	-0.9	-0.4	0.9
Arm fat percentage (right)	0.8	3.1	10.7	-1.4	-1.7	-0.1	-0.3	-2.2	-3.3	-1.1	0.3	-1.1	-2.8
Trunk fat-free mass	0.4	2.3	6.0	-2.5	-1.7	-0.3	-0.0	-2.2	-0.6	-0.6	-1.9	-1.5	-1.6
Hip circumference	0.8	3.4	9.7	-2.4	-1.8	-0.3	-0.2	-2.5	-2.8	-0.8	-0.5	-0.9	-3.1
Time employed in main current job	1.0	1.2	2.8	1.6	1.3	0.3	1.7	0.6	1.1	-0.8	-1.1	0.4	1.0
Alcohol intake versus 10 years previously	0.3	0.5	2.0	0.5	0.2	-0.7	0.5	-0.2	0.7	0.5	-0.1	1.4	0.8
Father’s age at death	0.6	0.8	1.8	1.0	1.1	0.7	1.3	0.9	0.9	0.1	-0.0	1.2	0.4
Worrier / anxious feelings	1.8	3.4	8.7	2.1	2.1	-1.1	2.5	3.0	1.2	-1.0	-0.6	1.4	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	4.5	-2.1	-1.2	-1.2	-0.7	1.3	-1.4	-0.3	0.1	-1.2	-0.8
Falls in the last year	0.8	1.1	3.8	-1.9	-0.8	-0.8	-0.7	-0.8	-1.1	-1.2	-1.4	0.2	-0.8
Hair/balding pattern: Pattern 3	0.4	0.6	2.3	-0.2	0.2	1.5	-0.5	0.4	0.9	0.1	-0.3	-0.9	1.2
Number of live births	1.5	2.2	4.8	1.7	1.4	-0.7	1.9	-0.1	-1.0	1.5	2.2	1.2	-1.7
Forced expiratory volume in 1-second (FEV1)	2.0	6.6	15.6	-2.7	-2.8	-0.2	-3.6	-2.3	0.4	-2.9	-3.9	-2.6	1.2
Pulse rate	0.9	1.5	6.5	-1.8	-1.5	0.1	-2.6	0.2	-0.6	0.5	0.4	-1.3	0.6
Happiness	0.7	0.8	3.3	0.1	0.2	0.6	-0.6	1.8	1.6	0.3	-0.7	0.4	1.1
Noisy workplace	0.6	0.8	1.3	-0.8	-1.1	-0.8	-1.1	0.6	-1.2	0.9	1.1	-0.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.7	-1.5	-1.1	1.0	-1.2	-0.4	-0.7	-1.6	-0.9	-1.9	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	2.5	-0.2	-0.3	0.3	-0.3	-0.1	-0.8	-1.6	-0.0	0.2	-0.4
Mouth/teeth dental problems: Dentures	0.6	1.0	3.7	1.5	0.4	0.8	0.6	0.9	0.3	1.9	1.0	0.7	0.6
Asthma	1.5	2.9	6.4	1.5	2.0	-0.3	2.5	-0.6	-0.6	1.6	2.4	1.1	-2.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.3	-1.5	-1.3	-0.0	-0.8	-0.6	-0.2	-0.1	-0.8	-1.2	0.0
Medication: Cholesterol lowering	0.5	0.9	2.4	-0.2	-0.5	1.1	-0.4	0.8	-0.3	-1.1	-0.6	1.6	1.5
Depression (self-reported)	0.6	0.7	2.5	-1.5	-0.2	-0.0	-0.7	0.1	-1.6	-0.0	-0.2	1.3	-0.6
Medication: Lansoprazole	1.4	1.6	6.7	-0.6	-1.4	0.6	-1.1	1.2	1.3	0.7	-0.8	-1.0	2.6
Prospective memory result	2.4	3.0	4.6	1.6	2.0	1.6	2.1	2.0	2.1	2.1	0.7	1.2	1.3
Lung cancer (father)	1.1	1.3	2.7	-0.5	-1.4	-1.5	-0.9	-0.1	-1.6	-1.5	-1.2	0.8	-0.6
Illnesses of mother	0.9	1.1	2.5	1.1	1.3	-0.9	1.1	-0.9	-0.7	0.4	1.6	-0.0	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	5.9	15.4	-2.4	-2.6	-0.2	-3.3	-1.6	0.2	-3.2	-3.9	-2.5	1.3
Pulse wave Arterial Stiffness index	0.9	1.1	4.2	0.0	-0.4	1.2	-0.6	1.2	0.7	-0.8	-2.0	-0.6	1.4
Impedance of arm (left)	0.1	0.5	1.3	1.0	-0.2	-1.2	-0.5	0.5	0.2	-0.9	-0.7	-0.5	0.9
Arm fat mass (right)	1.0	4.0	10.2	-2.0	-2.0	-0.0	-0.3	-2.8	-3.2	-1.1	-0.0	-1.4	-3.2
Trunk predicted mass	0.4	2.2	5.7	-2.4	-1.6	-0.2	0.0	-2.1	-0.4	-0.6	-2.0	-1.5	-1.6
Standing height	0.5	4.9	14.6	-3.0	-3.0	-1.2	-1.0	-2.4	-0.2	-1.5	-3.8	-2.2	-0.7
Length of working week for main job	1.6	1.8	7.6	-1.2	-0.7	-0.6	-0.8	1.2	0.1	-2.1	-2.8	-0.7	0.7
Exposure to tobacco smoke at home	2.0	2.2	6.9	0.3	0.5	0.9	1.1	-0.5	-0.6	2.6	2.6	0.2	-2.4
Breastfed as a baby	1.6	2.0	10.1	-0.3	0.7	3.2	-0.1	1.9	1.4	1.6	0.3	0.6	0.8
Tense / ‘highly strung’	0.6	1.0	3.3	-1.8	-0.4	1.3	-0.5	0.7	-0.3	-1.4	-1.3	-0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.5	-1.6	-0.3	0.4	-1.0	0.7	-0.3	1.5	1.3	-1.3	-0.0
Hair/balding pattern: Pattern 4	0.4	1.1	4.2	0.4	-0.5	-1.3	0.9	-2.0	-0.8	-0.9	0.2	-0.1	-1.5
Birth weight of first child	1.3	2.3	13.3	-0.8	-0.3	-0.6	-0.5	0.0	0.2	-2.7	-3.6	-0.9	0.7
Peak expiratory flow (PEF)	2.7	6.3	14.0	-3.3	-3.4	0.3	-3.7	-2.6	-0.8	-1.0	-2.0	-3.7	-0.7
Pulse wave reflection index	0.8	1.0	4.3	0.9	1.3	0.2	1.4	0.0	0.9	-0.7	-2.1	0.5	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.3	-0.6	0.0	-1.5	0.1	-0.2	-0.0	-0.6	-0.1	-1.4	0.2
Loud music exposure frequency	0.5	0.6	1.3	0.2	1.0	0.5	0.7	-0.1	1.0	0.9	0.2	1.2	0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.8	-0.6	-0.4	-0.1	0.2	-0.0	-1.4	0.1	0.9	-0.3	-0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.6	-1.2	0.1	-0.5	0.6	1.3	-0.1	-0.1	-0.0	0.4	0.1
Blood clot in the leg (DVT)	1.1	1.5	3.7	-0.9	-1.3	0.2	-0.3	-1.9	-0.8	0.7	0.6	-1.7	-1.9
Medication: Paracetamol	0.3	0.5	2.0	-0.1	0.4	-0.3	0.3	1.4	0.3	0.2	-0.2	1.3	0.8
Headache pain in last month	0.5	0.9	3.9	0.4	0.8	-0.7	1.1	2.0	0.8	0.2	0.7	-0.5	0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	2.1	0.6	0.4	-1.4	0.7	0.4	0.1	0.3	0.0	-0.7	-0.7
Glaucoma (self-reported)	1.5	1.8	6.3	0.9	1.6	1.2	1.1	0.8	1.1	-0.7	-1.3	2.5	1.1
Gout (self-reported)	1.0	1.3	4.1	-2.0	-1.4	1.6	-1.3	-0.5	-0.8	-0.4	-0.6	-1.3	-0.3
Hypothyroidism/myxoedema (self-reported)	2.0	3.8	13.5	2.4	2.2	-0.1	1.9	3.7	2.3	0.9	-0.6	0.5	1.9
Medication: Amlodipine	0.3	0.4	1.4	-1.2	-0.1	-1.2	-0.1	0.2	-0.2	0.4	0.7	-0.6	-0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.5	-0.3	0.7	-1.2	0.6	-0.6	-0.4	1.1	1.1	0.8	-1.1
Birth weight	0.2	0.5	2.9	0.7	0.3	-0.1	0.0	-0.1	-0.2	1.7	0.8	0.1	-0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.5	0.8	0.2	0.9	0.3	-0.0	0.6	-1.0	-0.0	0.4	1.6
High blood pressure (siblings)	0.5	0.8	4.5	-1.3	-0.3	0.5	-0.8	0.4	0.0	-0.2	-0.1	-2.1	0.4
Forced vital capacity (FVC), Best measure	1.1	4.2	14.1	-1.7	-1.6	-0.7	-2.3	-1.1	0.9	-2.7	-3.8	-1.9	1.8
Body fat percentage	0.9	3.4	11.9	-1.7	-1.7	-0.4	-0.4	-2.4	-3.5	-1.1	0.4	-0.9	-2.9
Leg fat percentage (right)	0.3	1.2	4.5	-0.3	-0.1	-0.5	0.5	-1.2	-2.1	0.1	1.3	0.2	-2.0
Arm fat-free mass (right)	0.4	2.1	6.4	-2.5	-1.5	0.0	0.1	-2.0	-1.0	-0.8	-1.4	-1.3	-1.8
Exposure to tobacco smoke outside home	0.4	0.5	2.1	0.3	0.0	-0.6	-0.1	-0.3	-1.2	0.6	1.5	0.0	-0.8
Comparative body size at age 10	0.2	0.4	0.9	-0.9	-0.5	0.4	-0.4	-1.0	-0.3	0.6	-0.8	0.7	-0.8
Number of full brothers	0.4	0.4	1.1	0.5	0.6	0.5	0.5	-0.9	0.8	-0.1	-1.1	-0.6	-0.5
Worry too long after embarrassment	0.7	1.2	2.5	0.9	1.1	-1.6	1.2	1.1	0.8	-1.3	-0.7	-0.6	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.5	6.5	-2.5	-1.6	2.1	-1.7	-0.1	-1.8	0.0	0.2	-2.2	-0.8
Wheeze or whistling in the chest in last year	0.5	0.8	2.2	-0.1	0.4	0.5	1.2	0.1	-1.2	0.1	1.1	1.5	-1.1
Number of children fathered	1.2	1.4	3.2	-1.0	-1.4	1.6	-1.1	-0.1	-1.2	1.8	1.1	-0.7	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.8	-0.3	-0.0	0.7	-0.3	-0.1	-0.2	-0.3	0.5	1.4	0.7
Age at first live birth	0.7	1.2	2.6	-1.1	-1.1	1.4	-1.6	0.5	0.0	-0.7	-1.0	-1.3	1.3
Pulse wave peak to peak time	0.9	1.1	3.5	-0.3	0.2	-1.3	0.4	-1.4	-0.8	0.8	1.9	0.5	-1.6
Health satisfaction	1.0	1.3	3.8	-1.6	-1.7	-0.5	-1.9	0.4	-0.5	-0.5	-1.2	-1.2	0.3
Shortness of breath walking on level ground	0.3	0.4	1.3	-0.2	-0.4	-1.0	-0.1	0.8	-1.1	-0.8	-0.1	0.0	0.0
Qualifications: College or University degree	0.3	1.0	3.1	-1.8	-1.1	0.1	-1.5	0.2	-1.0	-1.6	-0.2	-0.4	0.3
Eye problems/disorders: None of the above	0.8	0.9	2.2	-0.9	-0.9	-1.0	-1.1	0.5	-0.7	-1.0	-0.8	1.5	0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.3	-0.6	-0.7	1.4	-0.4	-1.4	-0.2	-1.8	-1.8	-0.7	0.2
Emphysema/chronic bronchitis	0.6	0.7	2.0	1.4	1.2	0.3	1.4	0.2	0.4	0.3	0.6	0.7	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	0.9	1.4	-0.3	0.7	-0.2	-0.3	0.3	1.0	0.5	-0.7
Neck or shoulder pain in last month	0.7	1.0	2.9	-1.0	-0.4	-0.9	0.1	-1.0	0.4	1.1	1.7	-1.7	-0.3
Medication: Blood pressure	0.4	0.8	2.5	-0.7	-0.6	1.6	-0.8	-0.7	-0.3	1.1	1.4	0.6	0.0
Angina (self-reported)	0.6	0.8	2.6	-0.9	-1.1	0.9	-0.8	0.4	-0.2	-1.6	-1.1	0.1	0.8
Migraine (self-reported)	0.7	0.8	4.4	0.4	-0.6	-1.0	-0.1	0.8	0.1	-0.3	1.3	-2.1	0.6
Medication: Ibuprofen	0.7	0.8	2.5	-1.5	-1.2	-0.4	-1.0	-0.2	-0.5	-0.3	-0.8	-1.6	-0.2
Medication: Allopurinol	0.2	0.3	1.0	-1.0	0.4	0.9	-0.0	0.4	0.1	0.7	0.5	-0.4	-0.2
Medication: Omeprazole	0.4	0.5	1.7	0.2	0.2	-1.0	0.8	1.3	-0.1	0.0	-0.7	1.2	-0.1
Medication: Seretide 50 evohaler	3.2	3.7	12.1	1.9	3.5	-0.4	2.6	1.8	1.3	1.7	1.7	2.0	-0.3
Mean time to correctly identify matches	0.8	1.5	5.2	-1.0	-0.8	-1.2	-0.3	-1.3	-2.3	-0.7	-0.2	0.8	-1.8
Heart disease (mother)	1.6	1.9	4.1	-2.0	-1.9	0.4	-2.0	0.7	-0.3	-1.2	-1.9	-1.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	4.5	0.3	0.0	2.1	-0.2	-0.9	0.1	0.7	-0.1	0.5	-0.1
Whole body fat mass	1.0	4.2	10.5	-2.5	-2.2	-0.2	-0.7	-2.8	-3.2	-1.1	-0.3	-1.4	-2.9
Leg fat mass (right)	0.6	2.2	7.0	-1.6	-1.2	-0.1	0.1	-2.1	-2.6	-0.7	0.3	-0.4	-2.5
Arm predicted mass (right)	0.3	1.8	5.2	-2.3	-1.3	0.1	0.3	-1.8	-1.0	-0.7	-1.2	-1.2	-1.8
Pulse rate, automated reading	0.7	2.3	7.1	-1.9	-2.4	0.3	-2.7	-0.4	-1.8	-0.6	-0.1	-1.4	-0.9
Alcohol intake frequency.	0.1	0.3	1.2	1.0	0.1	0.5	1.1	0.3	0.5	0.5	0.3	-0.5	0.2
Comparative height size at age 10	0.9	4.7	15.9	-3.0	-2.9	-0.0	-2.2	-1.5	0.4	-0.8	-4.0	-2.5	0.3
Number of full sisters	1.2	1.5	5.3	0.3	1.6	-0.5	0.8	0.5	0.1	2.3	1.6	1.3	-1.2
Suffer from ‘nerves’	0.7	1.1	3.2	-1.4	-1.0	-0.7	-0.7	0.1	-0.1	-1.5	-1.8	-0.8	0.6
Overall health rating	0.8	1.8	5.5	-2.0	-2.0	-0.7	-0.8	0.4	-2.3	0.4	-0.3	-0.1	-1.7
Chest pain or discomfort	0.3	0.5	2.0	-1.4	-0.6	0.3	-0.2	1.0	-0.0	-0.2	-0.9	-0.5	0.3
Had major operations	0.3	0.4	1.2	0.9	-0.4	1.1	-0.1	0.4	-0.2	-0.5	-0.3	-0.9	0.3
Age at last live birth	0.2	0.3	1.2	0.2	0.0	1.1	0.1	0.2	-0.6	-0.7	-0.1	-0.6	-0.1
Family relationship satisfaction	1.0	1.2	5.3	0.8	0.7	-0.6	0.5	0.8	2.3	-0.1	-1.0	0.5	1.8
Leg pain on walking	1.8	2.2	6.9	-2.3	-2.6	-0.5	-1.9	-0.7	-1.5	-1.5	-1.0	-0.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.5	-1.2	-0.9	0.1	-1.6	0.0	1.0	1.9	-0.1	-1.4	0.7
Commuting to job workplace: Car/motor vehicle	2.5	2.8	7.1	2.7	2.2	-0.8	2.5	1.4	1.0	-0.9	-0.4	2.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	5.1	-0.3	-0.7	-0.4	-0.7	-0.2	0.0	2.3	1.2	-0.7	-0.2
Medication: Aspirin	0.8	1.0	3.6	-1.0	-1.9	0.8	-1.2	-1.1	-1.1	-0.7	0.2	-0.6	-0.3
Supplements: Vitamin C	0.8	0.9	3.0	-0.1	-0.3	0.5	0.4	-1.2	-1.4	0.6	1.3	-0.4	-1.7
Knee pain experienced in last month	0.6	0.9	3.1	0.5	1.4	0.5	1.8	0.2	1.2	0.3	-0.8	1.2	-0.1
Hypertension (Self-reported)	0.4	1.2	5.3	0.2	-0.0	0.4	0.3	-1.3	-0.4	1.7	2.3	-0.7	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.6	0.4	-0.5	1.2	-0.7	1.5	0.8	0.0	-0.5	0.2	1.6
Illnesses of father: Heart disease	0.5	0.7	2.4	0.5	-0.3	0.7	0.2	-1.4	-0.5	-0.3	1.5	-1.0	-0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.2	0.8	0.4	0.9	0.3	-1.0	0.6	1.1	0.1	-1.0	-0.4
Smoking status: Previous	0.6	0.9	2.9	0.9	1.7	1.2	1.2	0.3	0.3	0.8	0.4	1.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	10.5	-2.7	-2.2	-1.3	-1.8	-2.0	-0.7	-1.3	-3.2	-2.3	-1.0
Whole body fat-free mass	0.5	2.9	7.1	-2.7	-2.0	-0.1	0.0	-2.3	-1.3	-1.0	-1.8	-1.6	-2.1
Leg fat-free mass (right)	0.9	4.5	10.0	-3.2	-2.5	-0.0	-0.3	-2.8	-2.5	-1.6	-1.6	-1.9	-2.6
Arm fat percentage (left)	0.7	2.7	10.1	-1.2	-1.4	0.2	-0.2	-1.8	-3.2	-1.1	0.6	-1.1	-2.7
Average weekly red wine intake	0.3	0.5	2.0	-0.7	-0.4	-0.6	-0.5	-0.6	-1.4	-0.4	0.6	0.4	-0.7
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.5	-0.9	-0.9	-1.3	-0.2	-0.4	-1.6	0.0	1.3	-0.8	-1.2
Mood swings	0.3	0.5	1.7	0.2	1.0	0.5	0.6	1.3	-0.2	0.3	1.0	0.6	0.0
Loneliness, isolation	0.6	0.8	2.5	-0.3	0.6	1.6	-0.1	0.7	0.7	-0.6	-0.3	0.9	1.6
Long-standing illness, disability or infirmity	0.6	0.9	3.9	-0.6	-0.5	1.1	0.0	1.4	-0.2	2.0	1.0	0.1	-0.2
Ever had bowel cancer screening	0.7	0.8	3.3	-0.3	-0.5	1.8	-0.2	-0.1	-1.2	0.2	0.5	1.4	-0.7
Diabetes diagnosed by doctor	0.2	0.3	1.1	-0.8	-0.7	-0.6	-0.2	0.4	-0.1	0.4	-0.0	-1.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	3.7	-0.6	-0.8	0.5	-0.3	-1.7	-1.9	-0.6	0.5	-0.6	-1.9
Friendships satisfaction	0.6	0.7	3.1	0.0	0.8	-0.5	0.7	0.3	0.9	0.0	-1.3	1.8	0.3
Qualifications: nursing, teaching	1.0	1.5	6.3	0.8	0.3	1.0	0.5	1.1	1.3	1.5	1.1	-2.5	0.7
Commuting to job workplace: Walk	0.7	0.8	2.9	1.3	1.1	0.5	0.6	0.1	1.7	-0.1	-0.0	0.0	1.1
Eye problems/disorders: Cataract	0.3	0.4	0.9	0.6	0.7	-0.2	0.6	-0.9	0.0	-0.3	0.5	-1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.5	-0.4	0.3	0.1	0.1	0.1	0.5	-0.1	-0.3	-0.5
Medication for cholesterol	0.7	1.1	4.2	-0.1	0.0	0.9	-0.5	-0.4	-0.1	-2.0	-1.4	1.2	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.5	-1.6	-1.2	-0.8	-1.6	-0.5	0.0	-1.1	-1.2	-1.1	0.0
Back pain experienced in last month	0.6	0.8	3.7	0.5	0.9	-0.2	0.6	0.2	1.9	0.4	-0.4	0.7	1.5
Mineral and other dietary supplements	0.5	0.6	1.7	0.7	0.3	-0.5	-0.2	0.9	0.3	-1.1	-1.3	-1.1	0.5
Breast cancer (self-reported)	0.5	0.6	2.1	-0.5	0.4	1.4	0.9	-0.6	0.0	-0.7	-0.6	1.2	-0.3
Asthma (self-reported)	1.3	2.6	6.0	1.6	1.9	-0.2	2.4	-0.4	-0.6	1.5	2.3	1.2	-2.2
Osteoporosis (self-reported)	0.8	1.0	3.3	0.8	0.2	-0.6	0.7	0.5	-0.7	1.8	1.8	-0.3	-1.1
Osteoarthritis (self-reported)	0.4	0.6	1.6	0.4	0.1	0.5	0.1	1.1	-0.4	-1.3	-1.0	0.7	0.7
Medication: Aspirin	0.7	0.9	3.0	-0.9	-1.7	0.6	-1.1	-1.3	-0.8	-0.7	-0.2	-0.5	-0.3
Medication: Gliclazide	1.0	1.1	3.2	-1.6	-1.0	1.0	-1.5	-0.7	0.2	0.1	-0.1	-1.8	0.1
Illnesses of father: None of the above (group 1)	0.3	0.3	1.2	-0.1	0.1	0.3	0.0	1.1	0.3	-0.8	-0.9	-0.1	0.6
Smoking status: Current	0.4	0.7	2.8	0.1	-0.8	1.0	-0.4	-1.2	-0.2	1.7	0.6	0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	8.1	-1.4	-0.9	0.2	-2.8	-1.2	-0.2	-2.4	-2.8	-0.5	0.8
Whole body water mass	0.5	2.9	7.0	-2.6	-1.9	0.0	0.0	-2.3	-1.3	-1.0	-1.8	-1.5	-2.1
Leg predicted mass (right)	0.9	4.6	10.2	-3.2	-2.5	0.1	-0.3	-2.8	-2.4	-1.6	-1.6	-1.9	-2.6
Arm fat mass (left)	0.9	3.6	10.7	-1.8	-1.7	0.1	-0.1	-2.4	-3.3	-1.3	0.2	-1.2	-3.1
Number of self-reported non-cancer illnesses	0.9	1.6	3.1	-1.3	-1.6	-0.0	-0.6	1.5	-1.7	1.6	1.8	-0.3	-0.6
Average weekly champagne plus white wine intake	0.5	0.7	2.2	0.4	1.2	0.5	1.0	1.5	0.2	-1.0	-0.2	1.0	0.0
Miserableness	0.1	0.2	0.7	-0.1	0.2	0.3	0.3	-0.7	-0.2	0.4	0.8	-0.3	-0.3
Guilty feelings	0.9	1.3	4.3	1.2	2.1	0.2	1.3	0.8	1.2	-0.8	0.2	0.9	1.5
Wears glasses or contact lenses	0.3	0.3	0.7	-0.1	-0.3	0.8	0.0	-0.7	-0.8	-0.7	0.7	0.5	-0.4
Ever taken oral contraceptive pill	0.6	0.6	3.0	0.1	0.5	-1.7	0.4	0.9	0.6	1.3	-0.0	-0.4	0.2
Hearing aid user	1.2	1.3	3.6	0.2	-0.5	0.8	0.6	0.3	-1.1	1.9	1.8	0.8	-1.8
Mother’s age at death	0.4	0.4	1.1	0.6	1.1	-0.3	0.8	0.5	0.6	-0.6	-1.0	0.3	0.3
Financial situation satisfaction	1.4	1.8	6.9	-1.6	-0.3	0.3	-0.7	-0.1	-0.2	-2.6	-2.6	0.8	0.4
Tinnitus: Yes, now most or all of the time	0.9	1.0	3.2	-1.4	-1.8	0.7	-1.4	-0.5	-0.8	-0.6	-0.8	-1.1	-0.0
Commuting to job workplace: Public transport	1.5	1.8	5.1	-2.1	-1.6	-0.4	-2.1	-0.4	-0.1	1.0	-0.5	-2.2	0.3
Eye problems/disorders: Glaucoma	2.1	2.5	6.0	2.0	2.5	1.3	2.0	0.8	1.3	0.7	-0.2	2.5	0.1
Medication: Blood pressure	0.6	1.2	3.7	0.5	0.2	-0.4	1.0	-0.6	-0.3	1.4	1.5	-1.4	-1.9
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.2	0.9	1.5	-0.1	1.3	0.1	0.4	1.1	0.7	1.3	-0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.9	-1.4	-1.2	0.4	-1.1	-0.0	0.6	0.4	-0.3	-0.7	0.8
High cholesterol (Self-reported)	0.7	1.3	4.5	1.3	1.2	-0.0	1.2	2.1	-0.0	0.8	1.5	1.2	0.3
Medication: Bendroflumethiazide	0.6	1.0	3.1	0.9	0.7	1.5	0.2	-0.9	0.3	1.0	1.8	-0.9	-0.7
Medication: Paracetamol	0.3	0.5	2.3	0.2	0.8	-0.4	0.5	1.5	0.0	0.3	-0.1	1.3	0.5
Medication: Lisinopril	0.7	0.9	3.3	0.1	0.1	0.5	0.7	-0.8	-0.5	1.8	1.4	-0.2	-1.4
Medication: Atorvastatin	1.3	1.6	4.0	-1.7	-1.2	-0.5	-0.7	-1.5	-1.8	0.9	0.2	0.3	-2.0
Illnesses of father: High blood pressure	0.5	0.7	2.3	0.3	0.8	-1.5	0.3	-0.9	0.5	0.8	1.0	-0.7	-0.6
Alcohol drinker status: Never	1.3	1.6	6.1	1.6	0.5	0.9	1.3	1.0	0.1	1.8	2.5	-0.4	-0.1
Ever smoked	0.4	0.8	3.3	-0.2	0.5	1.8	0.3	-1.1	-0.6	0.4	0.7	-0.2	-1.3
Basal metabolic rate	0.7	3.6	8.4	-2.9	-2.2	-0.2	-0.2	-2.7	-1.8	-1.1	-1.7	-1.7	-2.4
Leg fat percentage (left)	0.4	1.6	6.4	-0.9	-0.5	-0.3	0.2	-1.5	-2.5	-0.2	1.1	-0.2	-2.3
Arm fat-free mass (left)	0.5	2.5	6.2	-2.5	-1.7	-0.1	0.1	-2.4	-1.5	-0.9	-1.2	-0.9	-2.1
Number of operations (self-reported)	0.3	0.4	0.9	-0.7	-0.7	-0.8	0.5	0.4	-0.9	0.6	-0.2	0.5	-0.8
Average weekly beer plus cider intake	0.6	0.8	2.1	-0.6	-0.8	-0.3	-1.1	-1.2	-0.2	0.8	1.3	-1.4	0.0
Irritability	0.5	0.8	2.5	-0.5	-0.4	1.1	-0.3	1.3	-0.3	-1.6	-0.5	0.3	1.3
Risk taking	1.1	1.6	5.4	-2.3	-1.3	1.0	-1.5	-1.1	-1.5	-0.8	0.0	-0.6	-0.9
Ever had prostate specific antigen (PSA) test	1.3	1.5	5.1	0.7	1.3	0.8	0.8	2.3	1.3	-0.2	0.2	0.0	2.0
Fractured/broken bones in last 5 years	1.1	1.4	4.8	-1.7	-1.1	-2.2	-0.4	0.1	-1.7	-0.2	-0.7	-0.0	-1.1
Age started oral contraceptive pill	0.5	0.6	1.8	0.4	0.8	-0.0	1.0	1.4	-0.4	-0.8	-0.9	1.1	0.2
Diastolic blood pressure, automated reading	1.5	4.7	16.8	-2.5	-1.3	-0.2	-1.4	-4.1	-0.8	-2.7	-2.5	-1.9	-1.3
Ever depressed for a whole week	0.8	1.0	3.1	0.0	0.7	1.3	0.2	0.6	1.8	-0.2	-1.1	-0.1	1.7
Unable to work because of sickness or disability	0.3	0.4	0.9	0.5	1.0	-0.2	0.8	0.6	0.5	0.9	-0.5	0.4	0.1
Commuting to job workplace: Cycle	0.4	0.5	1.2	-0.7	-0.5	-0.7	-0.6	-0.4	-0.4	0.8	0.9	-1.1	-0.6
Myopia	3.2	4.7	13.6	-3.7	-2.9	-1.3	-2.2	-2.4	-2.8	-0.9	-0.4	-0.8	-1.7
Vascular/heart problems diagnosed by doctor	0.6	1.6	6.1	-0.1	0.3	-1.1	-0.5	1.6	0.9	-1.4	-2.5	-0.1	1.7
Cholesterol lowering medication	2.2	3.2	8.2	1.9	1.6	-0.4	2.3	1.3	0.3	2.9	2.6	1.1	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.7	0.7	0.5	-0.5	1.2	1.3	0.5	0.2	-0.8	1.2	0.4
Pain experienced in last month	0.5	0.9	2.2	-0.5	-0.5	-1.1	-1.4	-0.7	0.1	-0.8	-1.5	-1.3	0.4
Supplements: Calcium	0.4	0.4	2.3	0.2	0.6	1.5	0.9	0.2	0.4	0.6	0.4	-0.0	-0.1
Basal cell carcinoma (self-reported)	0.2	0.3	1.2	-0.4	-0.3	-0.1	-0.5	-0.6	0.6	0.3	-0.2	-1.1	0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.8	1.1	0.0	1.7	1.1	-0.8	-1.0	0.9	1.2	1.6	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.9	-1.1	-1.4	0.3	-0.3	-1.8	-0.9	0.6	0.6	-1.8	-2.0
Heart disease (siblings)	0.7	0.8	3.0	0.1	-0.7	1.1	0.1	-0.5	-1.7	-1.2	0.4	0.6	-1.2
Alcohol drinker status: Previous	1.1	1.3	4.2	-2.0	-1.0	-0.5	-0.5	-0.3	-0.9	-1.4	-2.1	0.2	-0.3
Pack years of smoking	0.7	1.0	2.3	0.4	0.5	1.1	1.1	-0.4	-0.1	1.4	1.5	-0.7	-1.5
Impedance of whole body	0.2	0.9	3.8	1.3	0.5	-2.0	-0.2	1.0	0.6	-0.4	-0.2	0.2	1.2
Leg fat mass (left)	0.7	2.7	8.3	-1.9	-1.3	-0.1	-0.0	-2.2	-2.9	-0.7	0.3	-0.6	-2.7
Arm predicted mass (left)	0.4	2.0	4.8	-2.2	-1.5	-0.1	0.3	-2.2	-1.2	-0.7	-1.3	-0.9	-1.8