Hub : Genes

ECHDC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1343	0.0517	2.6e-03	0.113	NA	0.101	NA	0.099	5.6e-09	NA	4.1e-08	NA	5.2e-08
2	GTEx	Spleen	0.4270	0.1180	4.5e-04	0.007	NA	-0.004	NA	-0.011	2.1e-01	NA	4.1e-01	NA	9.0e-01
3	GTEx	Whole Blood	0.0910	0.0320	9.7e-05	0.091	NA	0.055	NA	0.075	9.0e-09	NA	7.5e-06	NA	1.9e-07
4	NTR	Blood	0.0273	0.0081	6.9e-09	0.042	0.032	0.035	0.035	0.038	2.0e-13	1.1e-10	1.3e-11	2.2e-11	1.9e-12
5	ROSMAP	Brain Pre-frontal Cortex	0.0917	0.0294	2.3e-07	0.066	0.062	0.070	0.044	0.054	6.3e-09	2.2e-08	2.4e-09	2.4e-06	1.6e-07
6	YFS	Blood	0.3158	0.0391	0.0e+00	0.228	0.281	0.330	0.254	0.330	5.4e-73	1.1e-92	7.2e-112	1.3e-82	3.5e-112
7	TCGA	Thyroid Carcinoma	0.0770	0.0420	1.4e-03	0.009	0.014	0.015	NA	0.013	3.7e-02	1.5e-02	1.2e-02	NA	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.9	1.5	4.3	-1.9	-2.1	-0.6	-0.1	-0.7	-1.2	0.6
Bipolar Disorder or Schizophrenia	0.7	1.7	5.0	-2.2	-2.1	-0.8	-0.0	-0.3	-1.1	0.3
Depressed Affect (Nagel 2018)	0.0	0.1	0.4	-0.1	-0.3	-0.1	0.0	0.3	-0.1	0.6
Depression (Nagel 2018)	0.6	0.9	1.6	-0.6	-1.3	-1.1	-1.0	0.9	-0.9	0.6
Intelligence (Savage-Jansen 2018)	0.8	2.5	4.0	-2.0	-0.8	-1.4	-1.1	1.4	-2.0	2.0
Neuroticism (Nagel 2018)	0.5	1.2	7.5	-0.6	-2.7	-0.2	0.1	0.3	-0.2	0.8
Schizophrenia (2018)	0.3	0.5	1.9	-1.4	-1.1	-0.5	0.0	0.3	-0.5	-0.1
Schizophrenia vs Biploar Disorder	0.4	0.6	1.3	0.2	0.0	1.0	1.2	-0.5	0.9	-0.8
Worry (Nagel 2018)	0.5	1.1	5.4	-0.6	-2.3	-0.7	-0.4	0.1	-0.4	-1.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	-0.2	-0.3	-0.9	-0.8	0.5	-0.5	0.6
Alzheimer’s Disease (in father)	0.9	1.0	2.0	0.5	-0.3	1.4	1.3	-0.9	1.2	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.1	0.2	0.5	0.4	-0.6	0.3	0.9
Crohns Disease (2017)	0.1	0.3	0.9	0.6	0.6	-0.1	-0.5	-0.2	0.2	-1.0
Irritable Bowel Disease (IBD)	0.4	1.0	2.4	0.1	0.6	-1.3	-1.5	0.8	-0.7	-1.1
Ulcerative Colitis (UC)	1.5	2.7	6.4	-0.5	0.2	-2.3	-2.5	1.8	-1.7	-1.1
Major Depression (MDD)	1.0	1.2	4.4	-0.2	2.1	-1.2	-1.3	0.6	-0.7	-0.1
Reaction Time	0.4	0.7	2.0	-0.4	-1.1	-0.2	-0.5	1.4	-0.6	0.9
Verbal and Numeric Reasoning (VNR)	1.0	2.3	5.8	-2.4	-1.3	-1.0	-0.5	0.4	-1.9	2.0
Breast Cancer	0.2	0.6	1.6	0.6	-1.1	0.7	0.4	-0.3	0.5	1.3
Ovarian Cancer	0.8	1.1	2.5	0.3	-0.2	1.2	1.4	-1.6	1.0	0.7
Prostate Cancer	4.6	6.5	13.6	0.6	-1.8	3.3	3.3	-3.7	2.4	-0.4
Age at First Birth	0.2	0.3	0.7	0.1	-0.8	-0.5	-0.6	-0.6	-0.6	-0.6
Bipolar Disorder (2011)	3.9	3.7	6.8	-2.3	-1.7	-2.6	-2.1	1.0	-2.4	-0.2
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	0.3	1.2	0.4	0.3	-0.6	0.4	-0.2
Coronary Artery Disease (CAD)	0.2	0.3	0.8	-0.2	0.8	0.3	0.1	-0.6	0.4	-0.9
Crohns Disease (2012)	0.3	0.5	1.8	0.6	1.3	-0.0	-0.5	-0.5	0.2	-1.0
Mean Putamen Volume	0.5	0.6	2.9	-1.7	-0.5	-0.4	-0.0	-0.3	-0.8	-0.2
Fasting Glucose	1.5	1.8	4.5	1.9	1.0	0.8	0.2	-0.9	1.5	-2.1
HbA1C	0.4	0.4	2.7	0.1	0.1	0.3	0.4	-0.1	0.2	1.6
HDL Cholesterol	0.9	1.4	2.9	-0.0	-1.7	1.0	1.4	-1.7	0.7	1.0
LDL Cholesterol	0.4	0.7	2.6	-1.6	-0.5	-0.9	-0.1	-0.1	-0.7	-0.8
Lupus	0.9	1.3	2.8	-0.9	-0.5	-1.4	-1.4	1.7	-1.3	-0.0
Neuroticism (2016)	0.5	0.7	1.8	1.3	-0.9	0.9	0.7	0.1	1.1	0.0
Primary Biliary Cirrhosis	0.0	0.1	0.2	0.3	0.2	-0.1	-0.3	0.1	0.1	0.4
Rheumatoid Arthritis	0.4	0.6	1.7	0.2	0.4	0.2	0.1	-1.3	0.5	-1.3
Schizophrenia (2014)	0.3	0.7	3.0	-1.7	-0.9	-0.7	-0.2	0.2	-0.9	0.1
Triglycerides	0.4	0.7	2.7	-0.1	1.6	-0.4	-0.4	0.4	-0.2	-1.3
Type 2 Diabetes (T2D) (2012)	2.8	3.2	8.2	0.3	0.3	-2.1	-2.4	2.9	-1.6	1.5
Ulcerative Colitis	0.4	0.6	1.3	-0.5	-0.3	-1.0	-1.1	0.3	-0.8	-0.8
Blood Eosinophil Count	0.1	0.7	2.9	-1.7	-0.9	-0.4	-0.1	-0.5	-0.9	-0.2
Blood Platelet Count	0.8	9.4	18.9	2.9	-0.6	3.8	3.8	-2.8	4.3	0.5
Blood Red Count	2.8	27.0	57.0	2.5	0.9	6.9	7.5	-5.3	5.7	4.1
Blood White Count	1.1	8.4	13.5	2.4	1.5	3.5	3.7	-2.2	3.3	3.1
Heel T-Score	0.5	3.6	8.4	-0.3	0.2	-2.1	-2.6	2.9	-1.6	-1.8
BMI	0.0	0.2	0.9	-0.4	-0.0	-0.1	0.1	0.3	-0.5	0.9
Height	2.0	37.6	62.6	-5.8	-6.8	-6.9	-7.0	3.5	-7.9	-3.6
Waist Hip Ratio (WHR)	0.1	0.5	2.2	-0.1	1.2	0.1	-0.1	-0.3	-0.1	-1.5
Systolic Blood Pressure	0.1	0.6	2.7	-0.2	1.0	-0.4	-0.6	-0.2	-0.5	-1.6
Smoking Status	0.4	0.9	2.3	1.5	-0.0	0.9	0.5	-0.5	1.1	1.1
Allergy or Eczema	0.8	2.1	4.1	-2.0	1.6	-1.5	-1.4	0.8	-1.8	-0.6
Cardiovascular Disease	0.1	0.4	1.1	0.5	1.0	0.7	0.5	-0.1	0.2	0.8
Hypothyroidism (self reported)	1.1	2.5	6.8	0.1	-1.3	1.7	1.8	-2.6	1.6	-0.9
Respiratory disease	1.8	4.0	8.4	0.6	-0.9	2.4	2.8	-1.0	1.8	2.9
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.1	-1.3	0.2	-1.4	-0.9	-0.1	-1.4	-1.2
Lung FEV1/FVC ratio	1.2	6.2	11.5	-1.4	-0.9	-3.0	-3.4	3.3	-3.0	-1.1
Lung FVC	0.2	1.1	2.0	-1.2	-0.3	-1.4	-1.2	0.9	-1.3	-0.2
Neuroticism	0.2	0.5	2.6	-0.1	-1.6	-0.4	-0.1	-0.5	-0.0	-0.8
Chronotype (morning person)	1.3	2.9	6.8	0.3	-1.2	2.1	2.6	-1.9	1.8	0.9
Hair Pigment	0.0	0.7	2.3	-0.1	1.5	-0.0	-0.0	0.7	0.3	1.5
Tanning	0.2	2.2	4.0	-1.8	-2.0	-1.4	-1.0	0.6	-2.0	-1.0
Hand grip strength (left)	0.1	0.4	2.0	-0.1	-1.4	-0.3	0.0	-0.3	-0.1	-0.7
Number of treatments/medications taken	0.2	0.4	2.1	-0.5	-1.4	-0.3	-0.1	-0.5	-0.5	0.1
Average weekly spirits intake	0.8	1.0	6.7	0.2	-0.1	-0.2	-0.1	0.5	-0.3	2.6
Sensitivity / hurt feelings	1.4	2.3	14.1	-0.9	-3.8	-0.4	0.1	0.0	-0.7	0.9
Frequency of depressed mood in last 2 weeks	1.2	1.6	2.9	-1.0	-1.7	-1.6	-1.4	1.1	-1.3	0.1
Hearing difficulty/problems: Yes	0.3	0.4	1.9	-0.2	0.2	0.7	0.4	0.1	-0.0	1.4
Relative age of first facial hair	0.1	0.3	1.1	0.1	-0.1	0.4	0.5	-0.7	0.4	1.0
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	8.2	-1.4	-2.9	-0.6	-0.1	-1.0	-1.1	0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.5	-0.1	0.3	0.1	-0.3	-0.4	-0.7	0.2
Ever had hysterectomy (womb removed)	0.7	0.8	2.7	0.3	-1.6	0.9	0.9	-0.9	0.4	0.3
Systolic blood pressure, automated reading	0.3	0.8	3.3	-0.6	0.2	-0.6	-0.8	-0.1	-0.9	-1.8
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	4.0	0.7	0.1	-1.6	-2.0	1.7	-0.8	-0.9
Angina	0.5	0.6	1.2	-0.2	-1.1	-0.8	-1.0	0.7	-0.9	0.2
Medication for hormone replacement therapy	0.8	0.9	4.1	-0.4	-0.6	-0.6	-0.8	-0.1	-0.6	-2.0
Vitamin and mineral supplements	1.1	1.4	2.9	-0.7	0.5	-1.6	-1.6	0.2	-1.1	-1.7
Supplements: Zinc	1.0	1.0	3.1	-1.8	-0.9	0.0	0.2	-0.3	-0.8	-1.6
Medication: Co-codamol	0.3	0.3	0.8	-0.8	0.3	-0.3	-0.7	-0.1	-0.9	-0.5
Medication: Metformin	0.5	0.6	1.9	-1.4	-0.5	-0.8	-0.4	-0.0	-1.1	-0.5
Diabetes (father)	1.7	2.1	5.5	-2.3	0.5	-1.8	-1.1	0.7	-1.9	-0.7
Diabetes (mother)	0.5	0.6	2.4	-0.2	0.6	0.2	-0.0	-1.1	-0.1	-1.5
Severe depression (siblings)	1.2	1.3	2.6	-1.2	-1.0	-1.4	-1.1	0.9	-1.6	0.1
Pack years adult smoking proportion	0.2	0.3	1.0	0.2	0.5	0.5	0.7	-1.0	0.3	0.2
Impedance of leg (right)	0.7	3.2	6.0	2.2	0.6	2.1	1.5	-1.2	2.4	-1.7
Leg fat-free mass (left)	0.7	3.7	6.7	-2.2	-2.5	-2.0	-1.6	0.7	-2.6	0.7
Trunk fat percentage	0.8	3.1	6.7	-2.1	-0.9	-2.0	-1.8	1.4	-2.6	0.4
Hand grip strength (right)	0.1	0.3	1.0	0.1	-1.0	-0.7	-0.5	0.3	-0.3	-0.4
Townsend deprivation index at recruitment	1.6	2.3	4.5	-1.8	0.2	-1.7	-1.6	0.8	-2.1	-1.3
Current tobacco smoking	0.1	0.2	0.4	-0.5	0.4	-0.3	-0.4	0.2	-0.7	0.3
Average weekly fortified wine intake	0.3	0.3	0.9	-0.6	0.7	-0.1	-0.0	0.5	-0.3	0.9
Maternal smoking around birth	1.0	1.5	3.9	-2.0	-0.2	-1.2	-0.5	0.6	-1.9	0.9
Fed-up feelings	0.3	0.6	2.8	0.2	-1.7	-0.3	-0.4	0.3	-0.1	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	1.1	-0.5	0.8	0.7	-1.1	0.9	0.4
Relative age voice broke	1.4	2.1	4.8	2.2	0.8	1.3	1.2	-1.4	2.0	-0.4
Taking other prescription medications	1.7	2.6	4.5	-2.0	-2.0	-1.9	-1.5	0.1	-2.1	-0.3
Age when periods started (menarche)	0.2	0.4	1.5	1.2	0.0	0.4	0.1	-0.3	0.6	-0.8
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.8	0.1	-1.9	-0.4	-0.4	0.6	-0.5	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	6.2	0.5	1.0	-1.5	-2.0	2.5	-1.1	-1.2
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	5.7	-0.9	-2.4	0.1	0.2	-1.4	-0.2	-1.8
Qualifications: CSEs or equivalent	0.5	0.7	1.5	0.8	0.7	0.6	0.8	-0.4	1.2	-1.1
Serious illness, injury or assault to yourself	0.3	0.3	0.8	-0.9	-0.4	-0.6	-0.4	0.2	-0.8	0.4
High blood pressure	0.1	0.4	1.4	0.1	1.2	0.5	0.3	-0.8	0.0	-0.1
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.1	-1.8	1.1	-1.2	-0.9	0.4	-1.2	-0.1
Multivitamins +/- minerals	1.0	1.3	2.7	1.0	0.0	1.7	1.5	-0.3	1.4	1.0
Stomach or abdominal pain in last month	4.0	5.0	14.0	3.7	-0.1	2.6	1.8	-0.6	3.1	0.6
Supplements: Glucosamine	0.4	0.5	1.7	-0.1	-1.3	0.7	0.4	-0.1	0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.1	-0.1	-0.1	-0.3	0.2	-0.5	0.2
Medication: Atenolol	0.3	0.4	1.1	-0.2	0.2	0.8	0.8	-0.7	0.2	1.0
Medication: Levothyroxine sodium	0.6	1.1	2.6	0.2	0.6	1.1	1.2	-1.6	1.1	-0.8
Sitting height	1.2	8.7	19.8	-2.9	-4.5	-2.5	-2.5	-0.1	-2.9	-3.4
Chronic bronchitis/emphysema (father)	0.8	0.9	2.3	-1.5	0.6	-0.2	-0.0	-0.6	-1.0	-1.4
High blood pressure (mother)	0.3	0.5	1.1	0.3	-0.3	-0.8	-1.0	1.0	-0.4	-0.6
Body mass index (BMI)	0.2	1.1	2.8	-0.6	0.4	-0.9	-0.8	1.1	-1.2	1.7
Impedance of leg (left)	0.4	1.8	5.0	1.5	-0.1	1.1	0.7	-0.9	1.6	-2.2
Leg predicted mass (left)	0.7	3.7	6.8	-2.2	-2.5	-2.0	-1.6	0.7	-2.6	0.6
Trunk fat mass	1.0	4.4	9.3	-2.4	-1.6	-2.4	-2.2	1.5	-3.1	0.3
Waist circumference	1.0	3.6	7.9	-2.0	-0.5	-2.2	-2.1	1.7	-2.8	0.9
Number of incorrect matches in round	0.6	1.0	2.0	0.8	-1.4	0.8	1.0	-0.6	0.8	1.4
Past tobacco smoking	0.4	0.8	2.7	-0.3	1.6	-0.4	-0.7	0.7	-0.4	-1.2
Alcohol usually taken with meals	0.4	0.7	1.3	-0.9	-1.1	0.5	1.1	-0.2	0.3	1.1
Nervous feelings	0.3	0.6	1.7	-0.1	-0.3	-1.0	-0.8	0.6	-0.4	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.8	-1.0	-1.7	-1.1	-0.6	0.5	-1.0	0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.7	-0.4	0.3	0.4	0.3	0.1	-0.2	0.8
Hair/balding pattern: Pattern 2	1.1	1.4	2.4	0.0	0.5	-1.2	-1.5	1.5	-1.1	-1.4
Had menopause	0.4	0.5	1.6	-0.8	-0.9	0.2	0.1	-1.3	-0.7	-0.3
Had other major operations	0.7	0.9	1.7	-1.1	0.1	-0.9	-1.0	-0.7	-1.3	-1.1
Forced vital capacity (FVC)	1.0	3.8	6.0	-1.0	-2.0	-2.2	-2.4	1.4	-1.8	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.4	0.5	1.3	-1.7	-2.3	2.5	-1.2	-1.5
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.1	-1.6	-0.4	-1.6	-1.4	0.4	-1.5	-1.8
Qualifications: None of the above	0.4	0.9	1.6	0.7	0.8	1.2	1.2	-1.1	1.0	0.1
Financial difficulties in last 2 years	3.0	4.1	20.1	-1.6	-4.5	-1.6	-1.1	0.1	-1.4	-0.5
Mouth/teeth dental problems	0.3	0.4	1.0	1.0	0.8	0.4	0.1	-0.1	0.7	-0.8
Heart attack	0.6	0.8	2.4	0.5	0.7	0.5	1.2	-0.5	0.7	1.6
Allergy	0.3	0.7	3.4	0.9	-0.5	-0.1	-0.3	0.0	0.2	-1.9
Pain all over the body in last month	0.9	1.0	2.4	-1.5	-0.8	-0.9	-0.3	0.2	-1.3	1.1
Diabetes (self-reported)	0.3	0.5	1.4	-1.2	-0.1	-0.6	-0.2	-0.8	-0.8	-0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	2.3	0.2	0.1	0.1	0.0	0.7	0.3	1.5
Medication: Ramipril	0.3	0.4	1.4	1.2	0.3	-0.2	-0.7	0.8	0.1	-0.1
Medication: Simvastatin	0.6	0.9	2.0	0.0	0.7	1.0	1.1	-1.4	0.8	1.0
Fluid intelligence score	0.5	0.9	1.8	-1.3	-0.7	0.5	0.9	-1.3	-0.3	1.2
Illnesses of siblings	0.8	1.1	1.8	0.8	-1.2	1.1	1.0	-1.3	1.3	0.3
Neuroticism score	0.4	0.9	4.7	0.7	-2.2	-0.2	0.0	-0.5	0.5	-0.9
Weight	0.8	4.2	8.7	-2.2	-1.9	-2.3	-2.2	1.3	-2.9	0.5
Impedance of arm (right)	0.2	0.9	2.4	-1.6	0.3	-0.6	-0.5	0.2	-1.0	-1.4
Arm fat percentage (right)	0.5	1.9	3.9	-1.6	0.2	-1.3	-1.3	1.4	-2.0	1.2
Trunk fat-free mass	0.6	3.6	10.1	-2.0	-3.2	-1.7	-1.6	0.2	-2.4	-0.5
Hip circumference	0.7	3.1	6.1	-2.1	-1.7	-1.8	-1.6	1.1	-2.5	1.2
Time employed in main current job	0.8	0.9	2.5	-0.2	-0.6	0.9	1.4	-1.6	0.7	0.1
Alcohol intake versus 10 years previously	0.2	0.3	1.1	-0.2	0.7	-0.1	0.4	0.5	-0.1	1.0
Father’s age at death	0.7	0.9	1.4	1.1	-0.4	1.2	1.2	-0.5	1.1	0.8
Worrier / anxious feelings	1.5	2.9	6.8	0.2	-2.6	1.5	1.9	-2.4	1.4	-0.0
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.0	-0.7	-1.4	-1.3	-1.7	0.4	-1.5	-1.4
Falls in the last year	0.6	0.8	2.9	-0.1	-1.7	-0.3	-0.7	0.7	-0.6	1.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.6	-0.2	0.3	0.1	-0.6	0.5	-0.6
Number of live births	1.9	2.7	5.0	0.7	2.0	1.7	1.9	-1.1	1.2	2.2
Forced expiratory volume in 1-second (FEV1)	2.0	6.6	10.5	-1.6	-2.1	-2.9	-3.2	2.7	-2.6	-2.5
Pulse rate	1.1	1.8	3.8	0.9	0.2	-1.1	-1.9	1.9	-0.8	-1.7
Happiness	0.1	0.2	0.6	-0.0	0.0	0.3	0.0	-0.6	0.0	-0.8
Noisy workplace	0.5	0.6	1.3	0.5	1.1	-0.4	-1.1	0.8	-0.5	-0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.3	-0.8	-0.8	-1.1	-0.9	1.1	-0.8	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.0	0.2	-0.1	0.1	-0.1	0.5	0.2	1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	2.4	-0.3	1.6	0.2	0.4	-0.0	-0.3	0.9
Asthma	2.0	3.9	12.2	1.0	-1.3	2.0	2.2	-0.9	1.7	3.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.2	-0.7	-1.8	-1.0	-1.1	1.2	-1.2	0.1
Medication: Cholesterol lowering	0.5	0.7	2.4	-1.6	-0.9	-0.8	-0.5	-0.1	-1.0	-0.2
Depression (self-reported)	0.7	0.8	1.9	-1.1	-1.4	-0.9	-0.7	0.6	-1.0	0.2
Medication: Lansoprazole	0.8	0.9	2.2	0.2	0.3	-1.5	-1.4	0.5	-1.0	-0.8
Prospective memory result	2.3	2.8	5.9	0.8	-1.2	1.7	2.0	-2.4	1.9	-0.9
Lung cancer (father)	1.4	1.6	2.7	-1.3	-0.7	-1.0	-1.0	1.6	-1.5	1.5
Illnesses of mother	1.5	1.8	3.2	1.7	-0.3	1.8	1.6	-0.5	1.8	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	9.2	-1.8	-2.4	-2.9	-3.0	2.3	-2.5	-2.8
Pulse wave Arterial Stiffness index	1.4	1.6	3.1	-1.6	-1.8	-1.0	-0.9	0.0	-1.4	-1.3
Impedance of arm (left)	0.1	0.4	2.0	-0.7	-0.1	-0.1	-0.1	-0.1	-0.2	-1.4
Arm fat mass (right)	0.5	2.3	4.9	-1.6	-0.7	-1.6	-1.6	1.3	-2.2	1.0
Trunk predicted mass	0.6	3.5	10.0	-1.9	-3.2	-1.6	-1.5	0.1	-2.3	-0.5
Standing height	1.2	11.6	27.5	-3.7	-5.2	-3.2	-3.0	0.5	-4.1	-2.0
Length of working week for main job	1.5	1.7	7.5	-0.8	-2.7	-0.3	-0.6	-0.1	-0.8	-1.6
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.6	-0.1	0.5	0.8	-0.5	-0.1	0.6
Breastfed as a baby	0.2	0.3	1.3	0.1	-0.1	0.3	-0.1	-0.8	0.0	-1.1
Tense / ‘highly strung’	0.9	1.5	9.2	-0.3	-3.0	-0.8	-0.5	0.1	-0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	-0.2	-0.4	-1.1	-1.3	-0.6	-0.8	-1.3
Hair/balding pattern: Pattern 4	0.4	1.0	3.3	-1.8	-0.4	-0.6	0.1	-0.0	-1.1	1.3
Birth weight of first child	1.0	1.8	5.2	-1.4	-2.3	-0.2	-0.2	-0.6	-0.5	-2.2
Peak expiratory flow (PEF)	3.0	6.9	12.9	-1.2	-1.3	-3.4	-3.6	2.5	-2.6	-2.7
Pulse wave reflection index	1.4	1.8	4.4	-1.8	-2.1	0.4	1.0	-1.8	-0.4	-0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	0.8	-1.4	0.2	-0.0	-0.4	0.7	-0.6
Loud music exposure frequency	1.3	1.5	2.9	1.3	-1.1	1.5	1.2	-0.7	1.7	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.4	-0.4	0.4	-0.5	-0.2	0.6	-0.3	1.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.3	0.3	-1.1	-0.0	-0.2	-0.2	0.2	-0.6
Blood clot in the leg (DVT)	0.5	0.6	1.1	-0.8	0.0	-1.1	-0.9	0.7	-0.9	0.6
Medication: Paracetamol	0.4	0.7	2.2	1.2	-1.5	0.9	0.2	-0.2	0.8	0.0
Headache pain in last month	1.4	2.5	4.3	2.1	-1.8	1.3	0.5	-1.4	1.6	-1.9
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.6	1.9	0.5	0.8	0.5	0.2	1.0	0.8
Glaucoma (self-reported)	1.1	1.3	4.6	-0.7	-2.1	1.2	1.2	-1.0	0.4	0.4
Gout (self-reported)	1.7	2.3	4.9	-2.2	-1.0	-1.7	-1.4	0.8	-2.2	-0.4
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	4.6	0.3	-1.0	1.6	1.6	-2.1	1.4	-0.7
Medication: Amlodipine	0.5	0.7	2.4	1.2	0.9	0.3	-0.1	0.2	0.4	1.6
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	0.0	0.1	0.6	0.7	-0.1	0.4	0.2
Birth weight	0.1	0.3	0.9	-0.6	0.4	0.3	0.5	-1.0	-0.1	-0.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.5	0.5	1.2	0.0	-0.1	0.0	0.2	0.9
High blood pressure (siblings)	0.2	0.3	0.7	0.4	0.3	-0.7	-0.9	0.3	-0.5	-0.8
Forced vital capacity (FVC), Best measure	1.2	4.5	9.4	-1.6	-2.3	-2.2	-2.2	1.1	-1.9	-3.1
Body fat percentage	0.4	1.7	3.5	-1.3	-0.4	-1.4	-1.4	1.3	-1.9	0.8
Leg fat percentage (right)	0.1	0.5	1.4	1.1	0.7	0.6	0.1	0.4	0.4	1.2
Arm fat-free mass (right)	0.5	2.5	8.6	-1.1	-2.9	-1.6	-1.4	0.1	-1.8	-0.3
Exposure to tobacco smoke outside home	0.1	0.2	0.6	0.8	-0.4	0.1	-0.2	0.1	0.4	0.3
Comparative body size at age 10	0.2	0.6	1.5	-0.6	-0.7	-0.6	-0.4	0.8	-0.7	1.2
Number of full brothers	0.8	1.0	2.0	-1.3	-1.3	-0.1	0.4	-1.1	-0.3	-1.4
Worry too long after embarrassment	0.8	1.3	7.8	-0.3	-2.8	0.3	0.7	-0.8	0.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	8.5	-0.8	-2.9	-1.8	-2.0	1.3	-1.6	-0.6
Wheeze or whistling in the chest in last year	0.6	1.1	3.0	1.1	-1.1	0.9	0.7	-0.1	1.0	1.7
Number of children fathered	0.9	1.0	2.0	0.8	1.3	-1.0	-1.1	1.4	-0.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.2	0.4	0.2	-0.1	0.5	-0.2	0.1
Age at first live birth	0.5	0.8	1.6	-0.0	-1.0	-1.0	-1.2	1.3	-0.3	-0.7
Pulse wave peak to peak time	1.0	1.2	2.2	1.4	1.5	0.8	0.7	0.1	1.2	1.2
Health satisfaction	1.3	1.7	3.1	-0.9	-0.6	-1.5	-1.8	0.9	-1.6	-1.3
Shortness of breath walking on level ground	0.1	0.2	0.4	-0.6	-0.6	-0.4	-0.3	0.2	-0.3	0.3
Qualifications: College or University degree	0.4	1.2	2.7	-0.5	-1.1	-1.2	-0.8	1.4	-0.5	1.6
Eye problems/disorders: None of the above	0.6	0.7	1.2	-0.4	1.0	-1.1	-0.8	1.1	-0.8	-0.3
Mouth/teeth dental problems: Loose teeth	2.1	2.5	7.9	-2.8	-1.6	-1.3	-1.0	0.1	-1.9	0.4
Emphysema/chronic bronchitis	0.6	0.7	1.7	-0.3	-0.3	1.1	1.3	-1.1	0.3	0.6
Medication for pain relief, constipation, heartburn	0.8	1.4	6.9	-0.3	2.6	0.5	1.0	-1.0	0.7	0.0
Neck or shoulder pain in last month	0.5	0.7	3.1	1.8	-0.8	-0.0	-0.8	0.2	0.7	-0.4
Medication: Blood pressure	0.1	0.2	0.5	-0.7	0.6	-0.4	-0.5	-0.1	-0.4	-0.5
Angina (self-reported)	0.4	0.5	1.4	0.1	-1.2	-0.6	-0.9	0.7	-0.6	0.6
Migraine (self-reported)	0.8	0.9	3.6	1.0	1.9	-0.2	-0.7	-0.6	-0.0	-1.1
Medication: Ibuprofen	0.8	1.0	2.8	-0.6	-1.7	-0.8	-0.9	1.2	-0.9	0.2
Medication: Allopurinol	0.2	0.3	1.1	-1.0	0.1	0.1	0.1	-0.6	-0.5	-0.5
Medication: Omeprazole	0.2	0.3	0.9	-0.6	-0.9	0.1	0.2	-0.4	-0.5	-0.6
Medication: Seretide 50 evohaler	5.5	6.3	11.0	2.3	-0.7	3.3	3.0	-2.8	3.2	0.3
Mean time to correctly identify matches	0.7	1.2	2.1	-1.1	-1.5	-0.5	-0.6	1.3	-1.0	1.4
Heart disease (mother)	2.6	3.1	5.7	-1.3	-1.7	-2.4	-2.2	1.3	-2.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.3	-0.2	-0.0	-0.3	-0.1	0.9	-0.2	1.1
Whole body fat mass	0.8	3.2	6.9	-1.9	-1.2	-2.0	-1.9	1.5	-2.6	0.6
Leg fat mass (right)	0.2	0.8	1.4	-0.5	-0.4	-0.8	-0.9	1.1	-1.2	1.1
Arm predicted mass (right)	0.4	1.9	6.6	-1.0	-2.6	-1.3	-1.2	-0.1	-1.6	-0.3
Pulse rate, automated reading	0.6	2.1	4.4	0.3	0.7	-1.2	-2.1	2.0	-1.2	-1.7
Alcohol intake frequency.	0.0	0.1	0.3	-0.5	0.3	-0.1	0.3	-0.5	-0.1	-0.2
Comparative height size at age 10	1.6	8.9	13.3	-3.1	-3.1	-3.2	-3.2	1.0	-3.6	-2.9
Number of full sisters	0.6	0.8	1.8	-0.0	0.8	1.3	1.2	-0.8	0.9	0.3
Suffer from ‘nerves’	0.8	1.3	2.9	-0.6	-1.7	-1.2	-1.0	0.5	-0.9	-1.4
Overall health rating	0.8	1.8	3.2	-0.8	-0.6	-1.7	-1.7	1.3	-1.8	1.0
Chest pain or discomfort	0.5	0.7	1.1	-0.6	-0.7	-1.0	-1.0	0.7	-0.9	0.6
Had major operations	0.1	0.2	0.7	-0.9	0.3	-0.4	-0.0	0.0	-0.4	0.1
Age at last live birth	0.5	0.8	3.5	-0.5	-1.9	0.3	0.3	-0.1	0.3	1.1
Family relationship satisfaction	0.8	0.9	2.2	-0.7	-1.3	0.3	0.4	-1.4	0.1	-1.5
Leg pain on walking	2.6	3.2	6.6	-1.3	-1.1	-2.0	-2.1	2.1	-2.6	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.5	1.9	1.3	-0.6	-1.5	1.2	-0.3	-0.4
Commuting to job workplace: Car/motor vehicle	1.8	2.1	4.1	-0.1	-0.6	1.7	2.0	-1.8	1.1	1.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	7.1	0.6	2.7	-0.4	-0.5	0.1	-0.0	-1.3
Medication: Aspirin	0.9	1.2	1.9	-0.1	-1.1	-1.2	-1.4	1.4	-1.2	0.7
Supplements: Vitamin C	0.5	0.6	2.2	-0.7	-0.6	0.4	0.4	0.8	-0.4	1.5
Knee pain experienced in last month	1.1	1.7	2.9	0.9	-1.2	1.7	1.5	-1.7	1.0	0.6
Hypertension (Self-reported)	0.1	0.4	1.3	0.3	0.9	0.5	0.3	-1.1	0.1	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	4.2	0.5	1.2	-0.6	-0.8	-0.2	-0.2	-2.0
Illnesses of father: Heart disease	0.2	0.3	0.9	0.7	0.9	-0.2	-0.0	-0.3	0.5	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.6	0.7	0.3	0.5	-0.5	0.0	-0.3
Smoking status: Previous	0.7	1.1	2.0	0.3	-1.4	0.9	1.2	-1.3	0.7	1.0
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	7.6	-1.8	-2.8	-2.3	-2.1	1.6	-2.2	-1.4
Whole body fat-free mass	0.7	4.1	9.4	-2.2	-3.1	-2.0	-1.7	0.4	-2.6	-0.0
Leg fat-free mass (right)	1.0	5.4	9.7	-2.6	-2.8	-2.7	-2.2	0.9	-3.1	0.3
Arm fat percentage (left)	0.3	1.1	2.0	-0.9	0.2	-1.0	-1.1	1.2	-1.4	1.1
Average weekly red wine intake	0.4	0.5	1.9	0.7	0.8	-0.0	0.0	0.8	0.1	1.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	0.9	-0.2	0.1	-0.1	-0.3	0.3	-0.4
Mood swings	0.1	0.2	0.3	0.5	-0.0	0.4	0.3	-0.5	0.6	-0.1
Loneliness, isolation	0.4	0.5	2.7	-0.1	-1.6	-0.2	-0.2	-0.2	-0.3	-0.7
Long-standing illness, disability or infirmity	0.0	0.1	0.2	0.4	0.1	-0.2	-0.3	0.1	0.1	0.4
Ever had bowel cancer screening	0.4	0.5	1.1	-1.0	-0.9	-0.6	-0.4	-0.1	-1.1	0.5
Diabetes diagnosed by doctor	0.4	0.7	2.1	-1.4	0.3	-0.9	-0.4	-0.4	-1.2	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	5.4	-0.6	-0.6	-1.0	-0.6	1.3	-0.7	2.3
Friendships satisfaction	0.5	0.6	2.5	-0.7	-0.8	0.3	0.7	-0.1	-0.0	1.6
Qualifications: nursing, teaching	1.1	1.7	3.1	1.8	1.4	0.5	0.5	-1.8	1.6	-0.9
Commuting to job workplace: Walk	1.1	1.2	2.2	1.3	0.3	1.3	1.1	-1.2	1.5	-0.5
Eye problems/disorders: Cataract	0.6	0.7	1.8	0.1	-1.3	0.6	0.3	-0.8	0.4	1.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.7	0.1	-1.6	-0.5	0.0	0.7	-0.3	0.8
Medication for cholesterol	0.4	0.6	1.4	-1.0	-0.9	-0.3	-0.3	0.8	-0.5	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.5	0.1	-0.4	-0.9	-1.2	1.2	-0.8	0.0
Back pain experienced in last month	0.8	1.2	2.7	1.1	-1.1	1.1	0.6	-0.8	1.0	-1.6
Mineral and other dietary supplements	0.7	0.9	3.1	-0.6	-1.8	-0.8	-0.3	-1.3	-0.3	-0.7
Breast cancer (self-reported)	0.6	0.8	2.5	-0.4	-1.5	0.3	0.6	-0.2	0.1	1.6
Asthma (self-reported)	1.8	3.5	10.6	0.8	-1.3	1.9	2.1	-0.9	1.6	3.3
Osteoporosis (self-reported)	1.9	2.3	7.1	2.7	0.9	1.5	0.8	-1.0	1.8	1.0
Osteoarthritis (self-reported)	0.1	0.1	0.4	-0.4	0.3	0.1	0.1	0.1	-0.4	0.7
Medication: Aspirin	1.0	1.3	2.2	-0.3	-1.2	-1.2	-1.2	1.5	-1.3	0.7
Medication: Gliclazide	1.0	1.1	2.3	-0.7	-0.0	-1.2	-1.3	0.5	-1.3	-1.5
Illnesses of father: None of the above (group 1)	0.0	0.0	0.3	-0.1	-0.0	-0.0	-0.1	-0.5	-0.0	-0.2
Smoking status: Current	0.1	0.2	0.5	0.2	0.7	-0.2	-0.4	0.4	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	5.8	-0.6	-0.2	-1.0	-1.3	2.4	-0.8	-0.7
Whole body water mass	0.7	4.0	9.4	-2.1	-3.1	-2.0	-1.7	0.4	-2.6	0.0
Leg predicted mass (right)	1.1	5.6	10.0	-2.7	-3.0	-2.7	-2.2	0.9	-3.2	0.3
Arm fat mass (left)	0.4	1.7	3.6	-1.3	-0.7	-1.3	-1.3	1.2	-1.9	1.1
Number of self-reported non-cancer illnesses	0.4	0.8	2.2	0.1	0.1	-1.3	-1.5	0.9	-0.8	0.1
Average weekly champagne plus white wine intake	0.9	1.3	5.4	-1.0	-2.3	0.6	1.1	-0.7	0.5	0.4
Miserableness	0.0	0.1	0.5	-0.0	-0.1	0.1	0.1	0.3	-0.0	0.7
Guilty feelings	0.9	1.3	2.4	1.1	-1.2	1.3	1.3	-1.0	1.6	-0.2
Wears glasses or contact lenses	0.3	0.3	2.3	-0.3	0.2	-0.1	0.0	-0.0	-0.2	1.5
Ever taken oral contraceptive pill	0.2	0.2	0.5	0.3	0.3	0.4	0.6	-0.7	0.6	-0.5
Hearing aid user	0.6	0.7	2.7	-0.1	1.1	0.5	0.4	0.4	0.1	1.6
Mother’s age at death	0.6	0.8	2.8	-0.7	-1.7	0.6	0.8	-0.3	0.0	1.0
Financial situation satisfaction	1.4	1.7	9.5	-0.6	-3.1	-0.5	-0.6	0.8	-0.9	0.3
Tinnitus: Yes, now most or all of the time	2.3	2.6	4.5	-1.6	-0.1	-2.1	-2.1	1.2	-1.9	-1.4
Commuting to job workplace: Public transport	2.3	2.7	4.4	-1.7	-0.0	-2.0	-2.1	0.9	-2.1	-1.6
Eye problems/disorders: Glaucoma	2.4	2.8	5.5	0.1	-1.9	2.3	2.3	-1.7	1.5	0.6
Medication: Blood pressure	0.4	0.7	2.0	1.4	0.5	0.9	0.7	-0.8	0.9	0.2
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.7	0.9	-0.6	1.6	1.4	-0.8	1.0	0.6
Supplements: Fish oil (including cod liver oil)	1.2	1.5	4.2	-0.3	2.0	-0.7	-1.0	1.6	-0.8	-1.4
High cholesterol (Self-reported)	0.6	1.0	1.7	0.8	0.9	1.2	1.1	-0.7	1.3	0.7
Medication: Bendroflumethiazide	0.5	0.8	1.7	0.4	1.2	1.0	0.7	-1.3	0.5	-0.7
Medication: Paracetamol	0.4	0.7	1.3	0.8	-1.1	1.1	0.6	-0.5	0.9	0.5
Medication: Lisinopril	0.2	0.3	0.6	0.4	0.6	0.5	0.7	-0.4	0.4	0.6
Medication: Atorvastatin	1.7	2.2	4.3	-2.0	-0.4	-1.7	-1.1	1.5	-2.1	0.1
Illnesses of father: High blood pressure	0.1	0.2	0.5	0.7	0.1	0.4	0.5	-0.3	0.5	0.3
Alcohol drinker status: Never	0.4	0.5	0.9	0.4	0.7	0.6	0.7	-1.0	0.4	0.9
Ever smoked	0.5	0.9	5.2	0.2	-2.3	0.0	0.3	-0.4	0.2	0.7
Basal metabolic rate	0.8	4.2	8.2	-2.1	-2.9	-2.2	-1.9	0.7	-2.7	0.1
Leg fat percentage (left)	0.1	0.3	1.2	0.7	0.1	-0.0	-0.3	0.6	-0.1	1.1
Arm fat-free mass (left)	0.5	2.8	6.8	-1.7	-2.6	-1.6	-1.5	0.3	-2.2	0.1
Number of operations (self-reported)	0.7	1.1	2.9	-1.7	-1.4	-0.5	-0.1	-0.9	-1.4	0.2
Average weekly beer plus cider intake	0.5	0.8	1.9	1.4	0.9	-0.2	-0.8	0.8	0.5	-1.0
Irritability	0.4	0.7	2.4	-0.7	-1.6	-0.7	-0.9	0.6	-0.6	0.1
Risk taking	0.8	1.2	1.6	-0.5	-1.2	-1.1	-1.3	1.3	-1.3	0.8
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.3	0.6	-1.2	0.7	0.9	-0.5	1.0	-0.5
Fractured/broken bones in last 5 years	0.6	0.7	1.6	-0.5	-1.3	-1.1	-0.9	0.6	-0.9	0.4
Age started oral contraceptive pill	0.6	0.8	2.0	-0.7	-1.1	0.8	1.1	-1.4	0.2	-0.1
Diastolic blood pressure, automated reading	0.6	1.9	6.9	-0.6	-2.6	-0.8	-1.1	0.3	-0.9	-1.8
Ever depressed for a whole week	0.8	1.0	2.9	-0.8	-1.0	0.2	0.1	-1.5	-0.1	-1.7
Unable to work because of sickness or disability	0.7	0.9	3.1	0.2	-1.1	0.8	0.6	-1.8	0.6	-0.6
Commuting to job workplace: Cycle	0.9	1.1	4.5	2.1	0.5	0.6	-0.1	0.8	1.1	-0.7
Myopia	2.9	4.2	9.0	-1.2	-0.5	-2.4	-2.3	3.0	-2.3	1.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	1.0	-0.2	-1.0	-0.3	-0.2	0.5	-0.0	-0.2
Cholesterol lowering medication	1.9	2.8	4.4	1.1	2.1	2.0	2.0	-1.7	1.5	1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	-0.3	-0.8	0.5	0.7	-0.7	-0.0	-0.7
Pain experienced in last month	0.6	1.0	2.6	-1.6	0.8	-1.2	-0.7	0.4	-1.1	-0.2
Supplements: Calcium	0.6	0.7	1.8	-0.4	-1.4	0.8	0.7	-1.2	-0.1	-0.3
Basal cell carcinoma (self-reported)	0.5	0.6	1.0	-0.7	-0.6	-0.9	-0.6	0.5	-1.0	-0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.7	0.3	0.5	0.3	0.9	-0.3	0.4	1.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.3	-0.8	0.0	-1.2	-1.0	0.7	-1.0	0.5
Heart disease (siblings)	0.5	0.6	2.5	-0.5	0.8	-0.2	-0.1	0.5	-0.7	1.6
Alcohol drinker status: Previous	2.8	3.2	8.4	-2.4	-2.9	-1.7	-1.1	1.0	-1.8	-0.4
Pack years of smoking	0.2	0.3	1.1	0.2	0.8	0.5	0.6	-1.1	0.2	0.1
Impedance of whole body	0.1	0.5	2.1	0.5	0.1	0.6	0.4	-0.5	0.8	-1.4
Leg fat mass (left)	0.3	1.0	1.8	-0.6	-0.7	-1.0	-1.1	1.0	-1.3	1.1
Arm predicted mass (left)	0.5	2.5	6.4	-1.7	-2.5	-1.5	-1.3	-0.1	-2.1	-0.1