Best TWAS P=7.71e-19 · Best GWAS P=1.56e-20 conditioned to 0.00042
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ACO1 | 0.06 | 0.05 | lasso | 1 | 0.04 | 4.5e-06 | 8.9 | -8.9 | 7.7e-19 | -0.61 | 0.16 | 0.82 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | APTX | 0.07 | 0.04 | blup | 495 | 0.06 | 2.4e-07 | 4.7 | -5.2 | 1.8e-07 | -0.12 | 0.59 | 0.41 | FALSE |
| 3 | GTEx | Artery Tibial | ACO1 | 0.16 | 0.02 | enet | 13 | 0.06 | 9.0e-06 | 7.4 | -8.3 | 1.3e-16 | -0.37 | 0.42 | 0.49 | FALSE |
| 4 | GTEx | Brain Cortex | ACO1 | 0.21 | 0.08 | lasso | 5 | 0.15 | 7.5e-05 | -6.4 | -6.0 | 1.7e-09 | -0.51 | 0.05 | 0.67 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | B4GALT1 | 0.22 | 0.20 | lasso | 2 | 0.20 | 5.4e-07 | -4.8 | 5.3 | 1.4e-07 | 0.01 | 0.43 | 0.47 | TRUE |
| 6 | GTEx | Colon Transverse | GVQW1 | 0.15 | 0.03 | lasso | 5 | 0.08 | 1.3e-04 | -7.2 | -8.0 | 1.2e-15 | -0.46 | 0.30 | 0.26 | TRUE |
| 7 | GTEx | Thyroid | RP11-54K16.2 | 0.16 | 0.04 | lasso | 6 | 0.05 | 1.1e-04 | 4.9 | 5.2 | 2.0e-07 | 0.04 | 0.28 | 0.60 | TRUE |
| 8 | YFS | Blood | DDX58 | 0.03 | 0.03 | lasso | 4 | 0.03 | 5.3e-10 | 8.0 | 7.5 | 5.6e-14 | 0.86 | 0.02 | 0.98 | FALSE |