Hub : Genes

DDX58

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.1290	0.0420	8.3e-04	0.212	NA	0.191	NA	0.203	2.1e-10	NA	1.9e-09	NA	5.2e-10
2	GTEx	Muscle Skeletal	0.1187	0.0377	3.6e-04	0.100	NA	0.095	NA	0.096	4.6e-10	NA	1.3e-09	NA	1.0e-09
3	GTEx	Skin Not Sun Exposed Suprapubic	0.2310	0.0580	5.6e-07	0.098	NA	0.145	NA	0.182	4.8e-06	NA	2.3e-08	NA	3.2e-10
4	GTEx	Skin Sun Exposed Lower leg	0.1570	0.0370	6.6e-08	0.112	NA	0.163	NA	0.167	1.7e-09	NA	1.9e-13	NA	9.1e-14
5	YFS	Blood	0.0270	0.0091	4.0e-05	0.029	0.015	0.024	NA	0.029	5.8e-10	5.8e-06	2.2e-08	NA	5.3e-10
6	TCGA	Breast Invasive Carcinoma	0.0516	0.0242	1.2e-03	0.013	0.020	0.023	NA	0.013	8.0e-04	4.8e-05	1.5e-05	NA	8.3e-04
7	TCGA	Brain Lower Grade Glioma	0.1671	0.0611	1.7e-09	0.088	0.085	0.070	NA	0.087	3.7e-10	7.4e-10	2.1e-08	NA	4.3e-10
8	TCGA	Prostate Adenocarcinoma	0.0803	0.0345	4.9e-04	0.055	0.041	0.039	NA	0.045	2.1e-06	3.9e-05	5.7e-05	NA	1.7e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	1.1	1.7	3.9	-0.0	-1.6	-0.8	-1.1	-0.0	-2.0	-1.6	-1.7
Bipolar Disorder or Schizophrenia	1.1	2.6	4.3	1.0	-2.0	-1.6	-1.7	-0.5	-1.4	-1.8	-2.1
Depressed Affect (Nagel 2018)	1.8	3.8	6.2	1.5	-2.1	-2.3	-2.4	-1.4	-0.6	-2.5	-2.2
Depression (Nagel 2018)	3.0	4.5	7.6	2.8	-1.8	-2.6	-2.8	-1.1	0.9	-2.1	-1.9
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	-0.8	0.6	0.6	0.4	-0.2	-0.3	0.3	0.6
Neuroticism (Nagel 2018)	2.3	5.4	8.5	2.0	-2.3	-2.8	-2.9	-2.0	-0.5	-2.8	-2.3
Schizophrenia (2018)	0.6	1.3	2.0	1.3	-1.3	-1.4	-1.3	-0.6	-0.2	-1.1	-1.3
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	0.9	-0.3	-0.8	-0.6	-0.5	0.7	-0.1	-0.3
Worry (Nagel 2018)	1.1	2.4	3.8	1.6	-1.6	-1.9	-1.9	-1.1	-0.3	-1.7	-1.6
Alzheimer’s Disease (in mother)	0.7	0.8	1.9	-1.4	0.8	0.8	0.8	0.8	0.8	0.7	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.5	0.5	0.4	0.0	0.1	0.6	0.5	0.4
Alzheimer’s Disease (including proxy)	0.3	0.5	2.3	-1.5	0.5	0.7	0.4	0.3	0.4	0.5	0.4
Crohns Disease (2017)	0.1	0.2	1.2	-0.3	-0.3	0.0	0.5	-0.1	-1.1	-0.1	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.3	-0.5	-0.3	-0.0	-0.2	-0.6	-0.3	-0.5
Ulcerative Colitis (UC)	0.2	0.4	1.4	1.2	-0.4	-0.7	-0.6	-0.3	0.4	-0.4	-0.4
Major Depression (MDD)	1.7	2.1	4.6	1.2	-1.3	-1.3	-1.5	-2.2	-1.0	-1.6	-1.3
Reaction Time	0.5	0.9	1.8	1.3	-0.1	-1.1	-1.2	-0.9	1.2	-0.5	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.7	-1.3	0.8	1.2	1.2	0.7	-0.6	0.7	0.7
Breast Cancer	1.2	3.0	5.7	1.0	2.3	0.4	0.4	-1.8	2.4	1.6	2.3
Ovarian Cancer	0.9	1.2	1.8	0.6	-1.3	-1.1	-0.8	-1.2	-0.9	-1.2	-1.4
Prostate Cancer	0.3	0.4	1.9	-0.2	-0.7	-0.3	-0.2	0.5	-1.4	-0.4	-0.7
Age at First Birth	0.6	0.9	2.8	-1.5	0.2	0.9	0.8	1.7	-0.7	0.4	0.2
Bipolar Disorder (2011)	0.7	0.7	2.0	1.4	-0.3	-1.0	-1.2	-0.9	0.3	-0.5	-0.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	-0.8	0.8	1.0	1.4	1.0	-0.2	1.0	0.8
Coronary Artery Disease (CAD)	0.2	0.2	1.3	-0.5	0.0	0.3	1.2	-0.3	-0.1	0.4	0.0
Crohns Disease (2012)	0.3	0.4	1.8	-0.7	-0.5	0.0	0.3	-0.6	-1.3	-0.4	-0.6
Mean Putamen Volume	0.3	0.3	1.6	1.3	-0.1	-0.7	-0.4	0.0	0.7	0.0	-0.0
Fasting Glucose	0.2	0.2	0.5	0.7	-0.3	-0.6	-0.4	-0.0	-0.0	-0.6	-0.4
HbA1C	0.3	0.4	0.7	-0.3	0.8	0.7	0.8	-0.0	0.4	0.6	0.8
HDL Cholesterol	0.2	0.4	2.5	-0.5	-0.0	-0.1	-0.1	1.6	0.5	0.2	-0.0
LDL Cholesterol	0.4	0.6	1.7	-1.3	0.2	0.8	1.3	0.4	-0.8	0.4	0.2
Lupus	0.6	0.9	3.1	1.8	-0.2	-0.9	-0.2	-1.7	-0.4	-0.1	-0.2
Neuroticism (2016)	5.6	8.0	10.5	2.7	-3.1	-3.2	-2.9	-2.6	-1.6	-3.2	-3.1
Primary Biliary Cirrhosis	1.8	2.5	3.6	-0.9	1.9	1.7	1.5	1.8	0.9	1.9	1.9
Rheumatoid Arthritis	0.3	0.4	0.6	0.7	-0.7	-0.7	-0.5	0.0	0.3	-0.7	-0.7
Schizophrenia (2014)	1.0	2.2	3.8	1.9	-1.7	-1.8	-1.4	-0.7	-0.6	-1.3	-1.8
Triglycerides	0.6	1.0	2.5	-0.6	1.2	1.2	1.6	-0.1	0.0	1.1	1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.5	0.4	-1.0	-0.7	-0.6	-1.6	-1.2	-1.1	-0.9
Ulcerative Colitis	0.1	0.2	0.3	0.1	-0.5	-0.3	-0.3	-0.5	-0.4	-0.5	-0.5
Blood Eosinophil Count	0.1	0.7	1.2	1.0	-1.0	-1.0	-0.1	0.0	-1.0	-0.5	-1.1
Blood Platelet Count	0.1	1.4	3.6	-0.1	-1.9	-0.7	0.3	0.3	-1.6	-0.8	-1.8
Blood Red Count	1.1	10.6	56.6	-2.3	0.4	2.3	3.3	7.5	-0.5	2.5	0.4
Blood White Count	1.1	7.9	16.9	-0.1	-4.1	-1.8	-0.8	-0.2	-4.1	-2.9	-4.1
Heel T-Score	0.4	2.9	12.0	1.9	1.1	-1.0	-1.0	1.6	3.5	0.7	1.1
BMI	0.1	0.4	1.5	1.2	0.4	-0.4	-0.4	-0.9	0.4	0.0	0.3
Height	0.3	6.7	15.8	4.0	-2.1	-3.3	-2.5	-2.5	-0.9	-2.1	-2.1
Waist Hip Ratio (WHR)	0.3	1.2	2.6	-0.0	-1.6	-0.8	-0.7	-0.2	-1.5	-1.3	-1.5
Systolic Blood Pressure	0.5	2.3	4.2	2.0	-1.2	-1.9	-2.0	-1.3	-0.2	-1.3	-1.1
Smoking Status	0.1	0.1	0.3	-0.3	-0.3	0.2	0.0	-0.5	-0.4	-0.4	-0.4
Allergy or Eczema	0.4	1.0	3.4	0.1	0.9	0.5	0.7	1.9	0.7	1.1	0.9
Cardiovascular Disease	0.2	0.7	1.5	1.2	0.7	-0.3	-0.9	-0.7	1.0	0.2	0.7
Hypothyroidism (self reported)	1.7	3.9	7.5	2.7	-1.4	-2.5	-2.3	-2.2	-0.1	-1.7	-1.4
Respiratory disease	0.7	1.5	2.6	1.6	-1.4	-1.6	-1.0	0.4	-0.9	-1.0	-1.4
Type 2 Diabetes (T2D) (2018)	1.3	2.4	5.9	1.5	-1.3	-1.7	-1.2	-2.4	-1.1	-1.4	-1.3
Lung FEV1/FVC ratio	0.2	1.2	4.2	1.0	1.2	-0.3	-0.8	-0.0	2.1	0.5	1.2
Lung FVC	0.1	0.3	0.9	-1.0	0.4	0.6	-0.2	0.2	0.8	0.3	0.6
Neuroticism	1.1	2.7	4.9	2.0	-1.4	-2.2	-2.2	-0.7	0.7	-1.7	-1.5
Chronotype (morning person)	0.3	0.6	1.1	0.4	-0.8	-0.8	-0.6	-0.8	-0.8	-1.0	-0.8
Hair Pigment	0.1	3.9	5.6	2.0	-1.9	-2.3	-2.4	-2.3	-0.4	-2.0	-1.8
Tanning	0.1	1.2	3.4	-1.2	-1.2	0.0	0.2	0.6	-1.9	-1.1	-1.3
Hand grip strength (left)	0.3	0.8	1.3	-0.2	1.1	0.8	0.9	0.9	0.5	1.2	1.1
Number of treatments/medications taken	0.2	0.3	1.1	1.1	0.0	-0.3	-0.1	-0.9	0.4	-0.1	0.0
Average weekly spirits intake	0.5	0.7	1.8	0.5	-0.7	-0.8	-0.7	-1.3	-0.7	-0.8	-0.6
Sensitivity / hurt feelings	2.3	3.9	9.2	1.8	-1.7	-2.5	-3.0	-1.4	0.3	-2.3	-1.7
Frequency of depressed mood in last 2 weeks	4.7	6.5	10.8	2.9	-2.5	-3.3	-3.2	-1.3	0.0	-2.8	-2.5
Hearing difficulty/problems: Yes	0.5	0.8	2.7	0.5	-0.6	-0.8	-1.0	1.6	0.8	-0.5	-0.6
Relative age of first facial hair	0.5	1.1	2.4	1.2	1.3	0.1	-0.0	-0.2	1.6	1.0	1.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.5	0.6	0.2	-0.0	0.1	1.2	0.7	0.4	0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.6	0.2	-0.8	-0.6	-0.5	-0.1	-0.6	-0.6	-0.8
Ever had hysterectomy (womb removed)	1.5	1.7	7.4	1.1	1.1	-0.4	-0.6	-1.1	2.7	0.6	1.2
Systolic blood pressure, automated reading	0.3	1.0	1.4	1.0	-1.1	-1.2	-1.2	-0.8	-0.5	-1.0	-1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.1	-0.3	-0.4	0.3	0.4	-0.6	-1.0	-0.2	-0.3
Angina	1.0	1.3	1.9	1.0	-1.3	-1.4	-1.1	-0.7	-0.8	-1.3	-1.3
Medication for hormone replacement therapy	0.8	0.9	2.1	1.4	-1.0	-1.2	-0.9	-0.1	-0.0	-0.9	-1.0
Vitamin and mineral supplements	0.2	0.2	0.7	0.8	-0.0	-0.4	-0.2	-0.9	-0.4	0.1	0.0
Supplements: Zinc	2.5	2.7	5.8	-1.0	-2.1	-0.6	-0.5	-1.2	-2.4	-1.9	-2.1
Medication: Co-codamol	1.9	2.2	4.2	0.1	-1.7	-1.1	-1.2	-1.5	-2.0	-1.5	-1.8
Medication: Metformin	0.1	0.2	0.4	0.1	0.5	0.2	0.5	-0.7	0.1	0.5	0.6
Diabetes (father)	0.1	0.1	0.3	0.5	-0.1	-0.2	-0.1	-0.4	0.1	-0.1	-0.0
Diabetes (mother)	0.4	0.5	2.6	0.1	-0.4	-0.2	-0.0	-1.6	-1.1	-0.4	-0.3
Severe depression (siblings)	4.8	5.4	9.8	2.2	-2.0	-2.4	-3.1	-3.0	-0.5	-2.4	-1.9
Pack years adult smoking proportion	2.4	3.6	6.4	2.1	-2.0	-2.5	-2.2	-0.9	-0.7	-2.0	-2.0
Impedance of leg (right)	0.3	1.4	2.7	1.1	-1.2	-1.4	-1.7	1.1	0.2	-1.0	-1.1
Leg fat-free mass (left)	0.2	1.0	3.1	1.8	0.7	-0.3	0.3	-1.6	1.0	0.5	0.6
Trunk fat percentage	0.4	1.7	4.0	2.0	-1.0	-1.6	-1.2	-1.4	-0.2	-1.1	-1.1
Hand grip strength (right)	0.1	0.2	0.3	0.6	0.5	0.1	0.2	0.5	0.2	0.6	0.5
Townsend deprivation index at recruitment	0.5	0.7	1.6	1.3	-0.5	-1.0	-0.8	-1.1	0.2	-0.7	-0.5
Current tobacco smoking	0.3	0.4	0.8	0.7	-0.9	-0.5	-0.2	-0.1	-0.7	-0.7	-0.9
Average weekly fortified wine intake	1.9	2.2	4.2	1.7	-1.3	-2.0	-2.1	-0.6	0.4	-1.7	-1.3
Maternal smoking around birth	1.1	1.5	3.4	-0.3	-1.4	-0.4	-0.4	-1.7	-1.9	-1.4	-1.4
Fed-up feelings	1.6	2.8	4.9	1.8	-1.2	-1.9	-2.1	-2.2	0.1	-1.9	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.9	8.2	2.9	-1.6	-2.6	-2.5	-1.0	0.5	-1.8	-1.6
Relative age voice broke	1.2	1.8	3.7	0.5	1.9	0.8	0.6	0.6	1.7	1.7	1.9
Taking other prescription medications	0.2	0.4	1.1	1.0	0.0	-0.5	-0.4	-0.6	1.0	-0.1	0.0
Age when periods started (menarche)	0.1	0.2	0.4	0.4	-0.1	-0.7	-0.6	0.5	0.2	-0.3	-0.2
Bilateral oophorectomy (both ovaries removed)	3.6	4.1	9.6	3.1	-0.7	-2.6	-2.2	-2.6	1.6	-1.1	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	5.1	0.6	1.2	0.1	-0.2	0.7	2.3	0.9	1.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.6	-1.3	0.9	1.1	0.6	1.0	0.1	0.8	0.8
Qualifications: CSEs or equivalent	0.8	1.0	3.0	0.3	-0.5	-0.9	-1.4	-1.7	-0.4	-1.2	-0.5
Serious illness, injury or assault to yourself	2.0	2.5	5.4	2.0	-0.9	-2.1	-2.3	-1.5	0.5	-1.4	-0.9
High blood pressure	0.8	2.3	6.5	2.6	-0.8	-1.8	-2.0	-1.3	0.8	-1.1	-0.8
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.6	-0.7	1.9	1.5	1.6	2.6	1.4	2.0	2.0
Multivitamins +/- minerals	0.2	0.3	0.6	-0.7	-0.6	-0.1	-0.4	-0.1	-0.3	-0.8	-0.7
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.3	0.5	0.4	0.3	-0.5	-0.4	0.4	0.6
Supplements: Glucosamine	0.7	0.9	2.1	-1.5	0.8	1.1	1.2	0.5	-0.4	0.8	0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.2	0.6	-0.3	-0.0	0.3	-0.3	-1.1	0.0	-0.3
Medication: Atenolol	0.2	0.2	0.9	-0.9	-0.4	0.3	0.3	-0.4	-0.3	-0.4	-0.3
Medication: Levothyroxine sodium	0.3	0.5	1.8	1.3	0.7	-0.3	-0.2	-0.5	0.9	0.5	0.6
Sitting height	0.1	0.5	1.1	0.3	0.7	0.4	0.7	0.4	1.0	1.0	0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	1.3	0.1	-0.6	-0.3	-1.3	1.0	-0.0	0.0
High blood pressure (mother)	0.6	0.8	1.8	0.1	1.2	0.7	0.8	-0.4	1.0	1.0	1.3
Body mass index (BMI)	0.2	1.0	3.2	1.8	0.1	-0.8	-0.6	-1.7	0.7	-0.3	0.0
Impedance of leg (left)	0.5	2.3	4.2	1.5	-1.6	-2.0	-2.0	1.0	0.1	-1.4	-1.5
Leg predicted mass (left)	0.2	1.0	3.3	1.8	0.7	-0.4	0.3	-1.6	1.0	0.5	0.6
Trunk fat mass	0.4	1.7	5.0	2.2	-0.8	-1.6	-1.1	-1.6	-0.0	-1.0	-0.9
Waist circumference	0.6	2.4	5.3	2.3	-1.2	-1.8	-1.2	-1.9	-0.5	-1.4	-1.3
Number of incorrect matches in round	0.3	0.4	1.6	-1.0	-0.5	-0.0	0.1	-0.3	-1.3	-0.5	-0.6
Past tobacco smoking	0.4	0.8	1.4	0.1	-1.1	-0.9	-0.7	0.3	-1.2	-1.0	-1.1
Alcohol usually taken with meals	0.1	0.2	0.4	-0.7	0.5	0.4	-0.0	0.4	0.3	0.2	0.4
Nervous feelings	0.8	1.4	2.8	0.7	-1.3	-1.4	-1.7	-0.8	-0.6	-1.4	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	4.8	1.0	-2.1	-1.8	-1.5	-0.5	-1.1	-1.9	-2.2
Hearing difficulty/problems with background noise	0.9	1.4	2.6	0.6	-1.6	-1.2	-1.1	1.3	0.1	-1.3	-1.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.5	-0.1	0.3	0.2	-0.5	0.1	-0.1	-0.1
Had menopause	0.4	0.5	0.9	-0.3	0.8	0.8	0.9	0.3	0.0	0.9	0.7
Had other major operations	0.1	0.1	0.4	-0.7	-0.2	0.0	-0.1	0.3	-0.5	-0.0	-0.2
Forced vital capacity (FVC)	0.2	0.6	1.8	1.1	-0.0	-0.9	-1.3	-0.1	1.0	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.6	1.4	-0.1	-1.3	-1.6	-0.8	1.4	-0.5	-0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.4	-0.7	-0.9	-0.2	-0.7	-0.7	-1.2	-1.0	-0.9
Qualifications: None of the above	2.4	5.2	7.6	2.2	-2.8	-2.5	-1.9	-1.8	-1.5	-2.6	-2.7
Financial difficulties in last 2 years	0.7	1.0	1.7	0.3	-1.2	-1.1	-1.2	-0.9	-0.4	-1.3	-1.1
Mouth/teeth dental problems	0.7	1.1	2.0	-1.4	0.7	1.3	1.3	0.4	-1.2	0.8	0.6
Heart attack	3.7	4.7	6.6	0.9	-2.5	-1.9	-1.7	-2.5	-2.2	-2.5	-2.6
Allergy	0.3	0.6	2.7	-0.1	-0.5	-0.6	-0.8	-1.7	-0.1	-0.8	-0.6
Pain all over the body in last month	1.3	1.4	3.9	2.0	-0.4	-1.6	-1.2	-0.5	1.4	-0.6	-0.5
Diabetes (self-reported)	3.0	4.6	8.3	1.6	-2.3	-2.1	-1.6	-2.9	-2.0	-2.1	-2.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.1	-0.3	-0.5	-0.3	0.3	-0.5	-0.4	-0.3
Medication: Ramipril	0.7	0.9	5.6	0.8	0.2	-0.5	-0.8	-2.4	0.3	-0.3	0.1
Medication: Simvastatin	0.2	0.4	1.1	0.7	0.6	0.0	0.3	0.1	1.1	0.6	0.6
Fluid intelligence score	0.4	0.8	1.9	-1.2	0.2	1.1	1.4	0.7	-1.2	0.3	0.1
Illnesses of siblings	0.0	0.1	0.2	0.4	0.1	-0.2	-0.4	-0.1	0.2	-0.1	0.0
Neuroticism score	1.9	4.0	7.2	2.3	-1.9	-2.7	-2.5	-0.7	0.5	-2.2	-1.9
Weight	0.3	1.7	7.1	2.7	-0.1	-1.3	-0.7	-1.8	0.9	-0.4	-0.2
Impedance of arm (right)	0.2	1.1	2.0	0.2	-1.3	-1.1	-1.4	0.2	-0.4	-1.3	-1.2
Arm fat percentage (right)	0.2	0.9	2.2	1.5	-0.4	-1.1	-0.8	-1.4	0.4	-0.8	-0.5
Trunk fat-free mass	0.2	1.0	3.1	1.8	0.8	-0.2	0.4	-1.0	1.4	0.7	0.7
Hip circumference	0.1	0.5	2.1	1.5	0.2	-0.5	-0.1	-1.1	0.5	-0.0	0.1
Time employed in main current job	0.7	0.8	1.7	-0.7	0.8	0.8	0.9	1.3	0.7	0.8	0.8
Alcohol intake versus 10 years previously	1.1	1.6	4.0	2.0	-0.6	-1.6	-1.7	-1.0	0.9	-1.0	-0.5
Father’s age at death	1.9	2.6	3.7	-1.3	1.7	1.8	1.6	1.9	1.2	1.7	1.6
Worrier / anxious feelings	1.2	2.4	4.0	1.8	-1.6	-2.0	-1.9	-0.6	0.2	-1.6	-1.6
Frequency of tiredness / lethargy in last 2 weeks	6.1	9.8	14.3	2.5	-3.8	-3.7	-3.2	-2.0	-1.9	-3.6	-3.8
Falls in the last year	0.3	0.4	1.0	1.0	0.6	-0.3	-0.4	-0.2	1.0	0.1	0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.5	-0.1	-0.3	-0.1	0.2	0.2	-0.7	-0.1	-0.2
Number of live births	0.7	0.9	2.6	-1.6	0.0	1.2	1.3	0.4	-1.0	0.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.0	1.1	0.3	-0.8	-1.3	0.1	1.4	-0.0	0.4
Pulse rate	1.3	2.2	3.6	1.9	-1.6	-1.9	-1.3	-1.2	-0.4	-1.5	-1.5
Happiness	0.6	0.7	1.5	0.7	-1.2	-1.0	-0.3	0.4	-0.2	-0.9	-1.2
Noisy workplace	0.2	0.2	0.9	0.7	0.1	-0.3	-0.5	0.1	1.0	-0.1	-0.0
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.0	-0.9	1.6	1.8	1.9	2.0	0.7	1.9	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	0.3	-0.7	-0.8	-0.9	-0.2	-0.6	-0.7	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	1.4	1.2	-0.1	-0.7	-0.6	-0.1	0.9	-0.2	-0.0
Asthma	0.1	0.2	1.1	1.0	-0.3	-0.6	-0.0	-0.2	0.1	-0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	3.9	4.9	7.8	-1.0	2.1	2.3	2.8	2.3	2.1	2.6	2.2
Medication: Cholesterol lowering	0.9	1.4	2.4	0.9	-1.1	-1.1	-1.3	-1.6	-0.9	-1.3	-1.1
Depression (self-reported)	0.9	1.1	1.9	-0.0	-1.3	-0.6	-0.9	-1.3	-0.8	-1.4	-1.2
Medication: Lansoprazole	0.2	0.2	0.5	0.2	-0.7	-0.4	-0.3	-0.1	0.1	-0.6	-0.7
Prospective memory result	0.3	0.4	1.6	0.1	0.5	0.1	-0.8	0.5	1.3	0.2	0.5
Lung cancer (father)	2.5	2.9	5.3	1.6	-1.4	-2.1	-2.3	-1.6	0.3	-2.0	-1.5
Illnesses of mother	0.1	0.1	0.6	-0.0	-0.4	-0.0	0.2	0.1	-0.8	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	5.4	1.0	1.1	-0.3	-0.9	0.5	2.3	0.7	1.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.3	-0.6	-0.0	0.1	-0.6	-0.6	-0.4	-0.6
Impedance of arm (left)	0.4	1.8	3.6	-0.4	-1.9	-1.0	-1.0	0.6	-1.6	-1.5	-1.8
Arm fat mass (right)	0.3	1.3	4.8	2.2	0.0	-1.2	-0.8	-1.5	1.0	-0.4	-0.1
Trunk predicted mass	0.2	1.0	3.3	1.8	0.7	-0.3	0.4	-1.0	1.4	0.6	0.7
Standing height	0.1	0.7	4.2	2.0	-0.3	-1.0	-0.3	-0.4	0.5	0.0	-0.3
Length of working week for main job	3.8	4.2	13.7	3.7	0.3	-2.2	-2.3	0.2	3.1	-0.3	0.1
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.7	-0.5	0.1	-0.3	0.7	-0.8	-0.4	-0.5
Breastfed as a baby	3.3	4.2	5.4	-1.9	2.2	2.3	1.8	2.1	1.3	2.1	2.2
Tense / ‘highly strung’	0.7	1.1	2.7	1.6	-0.2	-1.4	-1.5	0.2	1.3	-0.5	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.5	1.0	-0.5	-1.0	-1.2	-0.7	1.2	-0.9	-0.5
Hair/balding pattern: Pattern 4	0.2	0.5	2.0	-1.1	-0.6	0.1	-0.0	-0.2	-1.4	-0.4	-0.7
Birth weight of first child	0.0	0.0	0.1	0.4	-0.1	-0.1	-0.0	0.3	-0.0	-0.0	-0.1
Peak expiratory flow (PEF)	0.3	0.7	2.4	0.5	0.9	-0.4	-1.6	-0.2	1.3	0.0	0.8
Pulse wave reflection index	1.5	1.8	3.0	-1.0	1.6	1.4	0.9	0.6	1.7	1.4	1.7
Ever highly irritable/argumentative for 2 days	4.1	4.9	7.1	1.0	-2.5	-2.2	-2.3	-2.6	-1.6	-2.7	-2.4
Loud music exposure frequency	0.3	0.3	1.0	-1.0	-0.1	0.4	0.4	0.9	-0.3	0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	2.8	-1.4	1.0	1.6	1.7	1.3	-0.1	1.5	1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	0.2	-0.9	-0.7	-0.9	-0.2	0.2	-0.9	-0.8
Blood clot in the leg (DVT)	0.2	0.2	0.7	0.4	0.4	0.4	0.2	0.4	0.9	0.5	0.5
Medication: Paracetamol	0.1	0.2	0.6	-0.1	0.3	0.2	0.3	0.6	0.8	0.5	0.4
Headache pain in last month	0.4	0.7	1.5	0.5	-0.9	-0.9	-1.2	-0.3	-0.5	-1.0	-0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.6	-1.5	-0.2	0.7	0.9	1.6	-0.4	0.2	-0.1
Glaucoma (self-reported)	0.5	0.6	2.2	-0.9	-0.1	0.7	1.2	1.5	-0.3	0.3	-0.1
Gout (self-reported)	1.0	1.4	3.4	0.7	1.3	0.4	1.0	0.9	1.8	1.5	1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.6	2.1	-0.2	-1.4	-1.3	-1.1	0.8	-0.6	-0.2
Medication: Amlodipine	0.7	1.0	2.5	0.8	-0.9	-1.0	-1.0	-1.6	-0.6	-1.1	-0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	1.0	0.7	0.1	0.6	0.6	0.8	0.9	0.7
Birth weight	1.7	3.7	6.4	-1.4	2.0	2.3	2.5	1.8	0.6	2.3	2.0
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.8	1.3	-0.4	-1.4	-1.7	-0.5	0.7	-0.8	-0.3
High blood pressure (siblings)	0.6	0.8	1.4	-0.1	-1.0	-0.6	-1.2	-0.8	-1.1	-1.1	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.0	3.9	1.2	0.8	-0.4	-0.8	0.2	2.0	0.6	0.9
Body fat percentage	0.4	1.7	4.1	2.0	-0.9	-1.6	-1.2	-1.4	-0.1	-1.1	-1.0
Leg fat percentage (right)	0.4	1.3	2.9	1.7	-0.8	-1.4	-1.2	-1.3	-0.1	-1.1	-0.9
Arm fat-free mass (right)	0.2	0.9	3.5	1.9	0.7	-0.2	0.6	-0.8	1.0	0.8	0.7
Exposure to tobacco smoke outside home	0.0	0.0	0.2	-0.2	0.2	0.2	0.1	-0.4	-0.1	0.1	0.3
Comparative body size at age 10	0.9	2.5	4.6	-2.0	1.8	2.2	1.8	0.1	0.4	1.4	1.7
Number of full brothers	0.2	0.3	0.6	0.1	0.5	0.2	0.3	0.7	0.5	0.8	0.6
Worry too long after embarrassment	1.4	2.3	4.0	1.0	-1.8	-1.7	-1.8	0.3	0.2	-2.0	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.0	2.0	0.5	-1.1	-1.9	-0.3	2.2	-0.2	0.5
Wheeze or whistling in the chest in last year	0.2	0.4	2.5	1.6	-0.4	-0.7	-0.1	0.3	-0.1	-0.2	-0.5
Number of children fathered	0.2	0.2	0.5	0.6	-0.3	-0.7	-0.7	0.3	-0.5	-0.2	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	-0.4	-0.8	-0.2	-0.3	-0.2	-0.7	-0.6	-0.8
Age at first live birth	0.1	0.1	0.7	0.2	0.1	-0.1	-0.3	0.4	0.9	0.1	0.2
Pulse wave peak to peak time	0.1	0.1	0.2	0.5	0.3	-0.2	-0.3	0.3	0.3	0.1	0.2
Health satisfaction	0.9	1.2	2.9	0.4	-1.3	-0.9	-0.1	-0.9	-1.7	-1.1	-1.4
Shortness of breath walking on level ground	0.6	0.8	1.0	0.9	-1.0	-1.0	-0.9	-0.1	-0.8	-1.0	-1.0
Qualifications: College or University degree	1.4	4.3	11.9	-1.9	1.7	2.1	1.9	3.4	0.7	2.1	1.6
Eye problems/disorders: None of the above	1.7	1.9	3.7	1.2	-1.0	-1.8	-1.9	-1.6	-0.0	-1.5	-1.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.2	0.1	0.2	0.1	-0.1	-0.0	-0.1	0.1
Emphysema/chronic bronchitis	0.8	0.9	2.4	1.5	-0.6	-1.3	-1.3	0.3	-0.2	-0.6	-0.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.5	0.7	-0.1	-0.2	-0.4	0.7	0.3	0.6
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.1	-0.3	0.0	-0.5	-0.5	-0.3	-0.3	-0.3
Medication: Blood pressure	0.6	1.0	3.4	1.6	-0.1	-0.9	-1.0	-1.9	0.3	-0.4	-0.1
Angina (self-reported)	1.1	1.5	2.2	1.0	-1.4	-1.4	-1.2	-0.7	-0.9	-1.4	-1.5
Migraine (self-reported)	0.8	1.0	1.4	1.0	-1.0	-1.1	-1.1	-1.0	-0.3	-1.2	-1.1
Medication: Ibuprofen	4.0	4.7	7.0	-0.4	2.2	1.9	2.3	2.3	2.6	2.6	2.3
Medication: Allopurinol	1.8	2.4	4.5	-0.3	1.9	1.1	1.1	1.6	2.1	1.8	1.8
Medication: Omeprazole	1.9	2.3	3.6	-0.3	-1.8	-1.1	-1.4	-1.0	-1.9	-1.9	-1.9
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.0	-0.0	0.2	0.3	0.1	-0.2	0.1	-0.0
Mean time to correctly identify matches	0.2	0.3	0.6	0.6	-0.2	-0.7	-0.8	-0.6	0.5	-0.4	-0.3
Heart disease (mother)	0.2	0.2	0.8	0.4	0.5	-0.0	-0.0	-0.3	0.9	0.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	0.5	-1.5	-1.1	-0.9	-0.0	-0.7	-1.3	-1.5
Whole body fat mass	0.4	1.7	5.7	2.4	-0.5	-1.5	-1.0	-1.7	0.4	-0.8	-0.6
Leg fat mass (right)	0.4	1.5	5.9	2.4	-0.2	-1.4	-1.1	-1.3	0.9	-0.6	-0.3
Arm predicted mass (right)	0.2	0.9	3.6	1.9	0.6	-0.3	0.5	-1.0	0.9	0.7	0.5
Pulse rate, automated reading	0.3	0.8	1.4	1.0	-1.0	-1.2	-1.1	0.4	-0.1	-0.9	-1.0
Alcohol intake frequency.	0.6	1.4	2.5	1.6	-0.3	-1.4	-1.5	-1.5	1.0	-0.9	-0.3
Comparative height size at age 10	0.1	0.5	1.2	-0.7	0.5	0.9	1.1	0.0	0.0	0.9	0.6
Number of full sisters	0.9	1.1	2.8	1.7	-0.9	-1.4	-1.3	-0.6	-0.2	-0.8	-0.8
Suffer from ‘nerves’	0.2	0.3	1.1	-0.4	0.3	0.4	0.7	1.1	0.3	0.5	0.3
Overall health rating	1.1	2.5	7.0	2.7	-1.4	-2.1	-1.5	-0.1	0.5	-1.3	-1.5
Chest pain or discomfort	1.0	1.4	2.2	1.2	-1.4	-1.3	-1.2	0.6	-0.3	-1.4	-1.5
Had major operations	1.5	1.8	2.7	-0.2	1.5	1.4	1.1	1.6	1.2	1.5	1.6
Age at last live birth	0.0	0.1	0.2	-0.5	0.1	0.1	-0.0	0.2	0.2	0.3	0.2
Family relationship satisfaction	4.8	5.9	9.5	1.7	-2.4	-2.8	-3.0	-2.4	-0.6	-3.1	-2.4
Leg pain on walking	3.2	4.0	5.5	1.2	-2.0	-2.1	-2.3	-2.3	-1.4	-2.3	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	-1.0	0.6	1.0	0.6	0.4	0.1	0.5	0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.3	0.4	-0.1	-0.3	-0.3	0.6	0.1	0.3
Illness, injury, bereavement, stress in last 2 years	4.1	5.0	10.2	-2.1	2.2	2.7	3.2	1.3	0.2	2.6	2.1
Medication: Aspirin	1.8	2.3	4.2	0.4	-1.9	-1.2	-1.1	-1.3	-2.0	-1.8	-1.8
Supplements: Vitamin C	0.4	0.4	1.9	-0.9	0.1	0.7	0.5	1.4	0.1	0.2	-0.0
Knee pain experienced in last month	1.5	2.3	4.9	2.2	-1.5	-2.0	-1.8	-0.1	-0.2	-1.4	-1.5
Hypertension (Self-reported)	0.7	2.1	6.6	2.6	-0.6	-1.8	-1.8	-1.3	0.9	-0.8	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	7.5	8.8	15.4	0.8	-3.9	-2.7	-2.5	-2.2	-2.7	-3.6	-3.8
Illnesses of father: Heart disease	1.2	1.7	3.0	0.1	-1.6	-1.0	-1.1	-1.1	-1.7	-1.3	-1.7
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.3	-0.7	-0.5	0.4	0.3	-0.5	-0.1	-0.7
Smoking status: Previous	0.5	0.8	1.6	-0.4	1.2	1.0	0.6	-0.3	0.9	1.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.0	1.3	0.6	-0.7	-0.7	-0.3	1.7	0.4	0.6
Whole body fat-free mass	0.2	1.2	4.2	2.1	0.7	-0.5	0.2	-1.4	1.4	0.6	0.7
Leg fat-free mass (right)	0.2	1.0	3.5	1.9	0.6	-0.5	0.2	-1.6	1.0	0.4	0.5
Arm fat percentage (left)	0.2	0.9	1.9	1.2	-0.7	-1.1	-0.7	-1.4	-0.3	-1.0	-0.8
Average weekly red wine intake	0.8	1.2	3.6	-1.9	0.1	1.1	1.4	1.0	-1.3	0.6	0.1
Handedness (chirality/laterality): Left-handed	2.0	2.4	5.0	-1.3	1.3	1.6	2.2	1.5	0.7	1.7	1.4
Mood swings	2.4	4.3	7.5	2.4	-2.0	-2.7	-2.6	-1.2	0.1	-2.2	-2.0
Loneliness, isolation	3.5	4.8	7.7	1.4	-2.8	-2.4	-2.2	-1.0	-1.9	-2.5	-2.8
Long-standing illness, disability or infirmity	0.4	0.6	1.3	0.5	-1.1	-0.6	-0.1	0.9	-0.5	-0.6	-1.1
Ever had bowel cancer screening	0.9	1.0	2.5	-0.2	1.3	1.0	0.4	0.5	1.6	1.0	1.3
Diabetes diagnosed by doctor	1.5	2.5	5.8	1.9	-1.2	-1.8	-1.4	-2.4	-0.5	-1.4	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.6	-1.3	0.5	0.8	0.6	0.0	0.3	0.4	0.4
Friendships satisfaction	0.2	0.2	1.2	-0.2	0.2	0.2	0.5	1.1	0.4	0.2	0.1
Qualifications: nursing, teaching	2.0	3.1	6.2	-0.9	1.6	1.8	1.8	2.5	1.3	2.0	1.7
Commuting to job workplace: Walk	0.3	0.4	0.7	0.8	-0.2	-0.7	-0.6	-0.8	0.7	-0.5	-0.2
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.7	-0.3	0.5	0.3	0.6	-0.8	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	3.0	0.7	0.9	-0.0	-0.2	0.4	1.7	0.7	1.0
Medication for cholesterol	0.1	0.2	0.6	-0.7	0.3	0.5	0.3	0.1	-0.5	0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	-0.5	-0.6	-0.0	0.3	-0.7	-1.0	-0.5	-0.6
Back pain experienced in last month	0.1	0.2	0.4	-0.6	0.3	0.7	0.4	0.7	0.2	0.2	0.2
Mineral and other dietary supplements	0.4	0.6	2.2	1.5	-0.5	-0.9	-0.8	-0.1	0.5	-0.3	-0.4
Breast cancer (self-reported)	0.3	0.4	1.4	1.2	-0.3	-0.7	-0.8	0.3	0.3	-0.2	-0.2
Asthma (self-reported)	0.1	0.2	1.3	1.2	-0.2	-0.6	-0.0	0.0	0.3	-0.1	-0.2
Osteoporosis (self-reported)	0.8	1.0	3.2	1.4	0.5	-0.7	-1.1	0.4	1.8	0.3	0.6
Osteoarthritis (self-reported)	0.8	1.1	1.8	1.3	-0.9	-1.3	-1.2	0.7	1.0	-0.8	-0.9
Medication: Aspirin	3.3	4.3	8.0	0.2	-2.6	-1.5	-1.3	-1.7	-2.8	-2.4	-2.6
Medication: Gliclazide	1.0	1.1	5.4	0.5	-0.7	-0.8	-0.6	-2.3	-0.7	-0.9	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	-0.4	0.5	0.6	1.0	0.8	-0.1	0.5	0.5
Smoking status: Current	0.3	0.4	0.9	0.1	-0.9	-0.2	0.1	0.1	-1.0	-0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.6	-1.0	1.9	1.1	0.1	0.8	1.3	1.5	1.9
Whole body water mass	0.2	1.1	3.8	1.9	0.7	-0.4	0.3	-1.4	1.3	0.6	0.7
Leg predicted mass (right)	0.2	1.0	3.6	1.9	0.6	-0.5	0.2	-1.6	1.0	0.4	0.5
Arm fat mass (left)	0.2	1.0	3.8	2.0	-0.1	-1.0	-0.5	-1.4	0.7	-0.4	-0.2
Number of self-reported non-cancer illnesses	0.5	0.9	2.6	1.6	-0.0	-0.8	-1.1	0.1	1.5	-0.3	0.0
Average weekly champagne plus white wine intake	0.6	0.8	2.7	-0.4	-1.1	-0.3	0.2	-0.5	-1.6	-0.9	-1.2
Miserableness	0.8	1.3	2.2	0.8	-1.5	-1.4	-1.1	-0.4	-0.6	-1.4	-1.5
Guilty feelings	0.8	1.2	2.1	1.1	-1.1	-1.4	-1.4	0.3	0.4	-1.2	-1.2
Wears glasses or contact lenses	0.3	0.3	0.8	-0.1	-0.9	-0.3	-0.4	0.1	-0.6	-0.6	-0.9
Ever taken oral contraceptive pill	0.9	1.0	3.0	0.2	1.3	0.6	0.2	0.5	1.7	1.0	1.3
Hearing aid user	0.3	0.4	1.1	-0.6	-0.6	-0.1	-0.6	-0.0	-1.1	-0.5	-0.6
Mother’s age at death	0.6	0.8	1.2	0.4	-1.0	-1.1	-1.0	-0.7	-0.8	-1.1	-0.9
Financial situation satisfaction	2.6	3.2	4.9	1.5	-2.2	-2.1	-1.9	-0.9	-0.4	-2.1	-2.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	-1.2	0.5	1.0	0.8	1.0	-0.2	0.6	0.5
Commuting to job workplace: Public transport	0.5	0.6	0.9	0.6	-0.6	-0.7	-0.9	-1.0	-0.6	-0.8	-0.7
Eye problems/disorders: Glaucoma	0.7	0.8	2.4	-1.1	-0.2	0.8	1.4	1.6	-0.5	0.4	-0.1
Medication: Blood pressure	1.0	1.9	2.9	1.4	-1.7	-1.7	-1.4	-0.7	-0.5	-1.4	-1.7
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.4	0.3	-1.8	-1.2	-0.6	-0.9	-1.1	-1.5	-1.9
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.3	-0.6	0.6	0.4	0.5	-0.1	0.3	0.5	0.5
High cholesterol (Self-reported)	0.1	0.1	0.4	0.2	-0.2	-0.3	-0.5	-0.4	-0.1	-0.6	-0.2
Medication: Bendroflumethiazide	0.1	0.2	0.6	0.4	-0.3	-0.3	-0.5	-0.8	-0.3	-0.3	-0.4
Medication: Paracetamol	0.6	1.0	1.4	-1.0	0.8	1.1	1.1	1.2	0.7	1.1	0.9
Medication: Lisinopril	0.9	1.2	4.9	2.2	0.4	-1.0	-0.5	-0.6	1.6	0.3	0.5
Medication: Atorvastatin	3.5	4.3	7.8	1.2	-2.3	-1.8	-1.9	-1.6	-2.8	-2.3	-2.4
Illnesses of father: High blood pressure	0.2	0.2	1.0	0.0	0.4	0.3	-0.0	1.0	0.6	0.5	0.4
Alcohol drinker status: Never	0.5	0.6	2.3	0.1	1.0	0.1	0.3	-0.0	1.5	0.8	0.9
Ever smoked	0.4	0.6	1.8	1.3	0.7	-0.1	0.3	-0.2	1.3	0.7	0.7
Basal metabolic rate	0.2	1.3	5.2	2.3	0.6	-0.6	0.1	-1.4	1.4	0.4	0.5
Leg fat percentage (left)	0.6	2.1	4.5	2.1	-1.1	-1.8	-1.6	-1.4	-0.1	-1.4	-1.2
Arm fat-free mass (left)	0.3	1.8	5.1	2.3	1.2	-0.4	0.3	-1.1	2.1	0.9	1.1
Number of operations (self-reported)	0.4	0.6	1.3	1.0	-0.4	-1.0	-1.1	-0.7	0.2	-0.6	-0.3
Average weekly beer plus cider intake	1.2	1.8	4.2	1.8	-0.9	-1.6	-1.2	-2.1	0.0	-1.1	-0.8
Irritability	0.4	0.7	1.7	1.3	-0.6	-1.2	-0.9	-0.7	0.2	-0.8	-0.7
Risk taking	0.3	0.4	1.1	0.8	0.8	-0.2	-0.7	-0.0	1.0	0.3	0.7
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.5	-1.0	1.0	1.2	1.2	1.1	0.6	1.2	0.9
Fractured/broken bones in last 5 years	0.6	0.8	1.7	1.2	-0.4	-1.0	-1.3	-0.7	1.0	-0.6	-0.4
Age started oral contraceptive pill	1.8	2.2	4.5	-0.1	1.8	1.1	0.8	2.1	1.6	1.8	1.7
Diastolic blood pressure, automated reading	1.1	3.3	6.1	2.3	-1.7	-2.5	-2.2	-0.5	0.2	-1.9	-1.8
Ever depressed for a whole week	1.1	1.4	3.3	-0.6	-1.3	-0.8	-1.1	-0.3	-1.8	-1.5	-1.4
Unable to work because of sickness or disability	1.6	2.1	4.2	1.9	-1.2	-2.0	-1.6	-1.0	0.4	-1.4	-1.2
Commuting to job workplace: Cycle	3.3	3.9	6.7	0.8	-2.5	-2.0	-1.3	-1.0	-2.4	-2.3	-2.6
Myopia	0.7	0.9	2.0	-1.4	0.6	1.1	1.4	0.7	-0.4	0.9	0.6
Vascular/heart problems diagnosed by doctor	1.4	3.9	10.0	-3.2	1.2	2.4	2.5	1.9	-0.5	1.6	1.3
Cholesterol lowering medication	0.1	0.1	0.2	0.4	-0.4	-0.3	0.2	0.1	-0.0	-0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	4.7	0.1	-2.0	-1.4	-1.8	-1.0	-1.8	-2.2	-2.0
Pain experienced in last month	0.0	0.1	0.3	-0.0	0.2	0.3	0.6	0.0	-0.1	0.2	0.2
Supplements: Calcium	0.4	0.5	1.7	0.6	0.1	-0.6	-0.9	-1.3	0.5	-0.5	0.1
Basal cell carcinoma (self-reported)	1.4	1.6	3.7	-1.9	1.1	1.7	1.5	0.7	-0.2	1.2	1.2
Heart attack/myocardial infarction (self-reported)	3.1	3.9	6.1	0.6	-2.4	-1.6	-1.3	-2.1	-2.3	-2.3	-2.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.0	0.4	0.7	0.2	0.3	0.6	0.5	0.5
Heart disease (siblings)	0.3	0.4	0.9	0.6	0.7	0.2	0.1	-0.9	1.0	0.4	0.7
Alcohol drinker status: Previous	0.4	0.4	2.0	-0.2	-0.5	0.3	0.7	0.3	-1.4	-0.0	-0.5
Pack years of smoking	2.7	4.0	6.9	2.3	-2.0	-2.6	-2.3	-1.1	-0.7	-2.0	-2.1
Impedance of whole body	0.4	1.9	3.4	0.4	-1.8	-1.5	-1.6	0.7	-1.0	-1.5	-1.8
Leg fat mass (left)	0.5	2.0	8.1	2.8	-0.3	-1.7	-1.3	-1.5	0.9	-0.7	-0.4
Arm predicted mass (left)	0.3	1.7	5.0	2.2	1.2	-0.3	0.4	-1.1	2.0	1.0	1.1