Hub : Genes

DDX58

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Transverse 0.1290 0.0420 8.3e-04 0.212 NA 0.191 NA 0.203 2.1e-10 NA 1.9e-09 NA 5.2e-10
2 GTEx Muscle Skeletal 0.1187 0.0377 3.6e-04 0.100 NA 0.095 NA 0.096 4.6e-10 NA 1.3e-09 NA 1.0e-09
3 GTEx Skin Not Sun Exposed Suprapubic 0.2310 0.0580 5.6e-07 0.098 NA 0.145 NA 0.182 4.8e-06 NA 2.3e-08 NA 3.2e-10
4 GTEx Skin Sun Exposed Lower leg 0.1570 0.0370 6.6e-08 0.112 NA 0.163 NA 0.167 1.7e-09 NA 1.9e-13 NA 9.1e-14
5 YFS Blood 0.0270 0.0091 4.0e-05 0.029 0.015 0.024 NA 0.029 5.8e-10 5.8e-06 2.2e-08 NA 5.3e-10
6 TCGA Breast Invasive Carcinoma 0.0516 0.0242 1.2e-03 0.013 0.020 0.023 NA 0.013 8.0e-04 4.8e-05 1.5e-05 NA 8.3e-04
7 TCGA Brain Lower Grade Glioma 0.1671 0.0611 1.7e-09 0.088 0.085 0.070 NA 0.087 3.7e-10 7.4e-10 2.1e-08 NA 4.3e-10
8 TCGA Prostate Adenocarcinoma 0.0803 0.0345 4.9e-04 0.055 0.041 0.039 NA 0.045 2.1e-06 3.9e-05 5.7e-05 NA 1.7e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.1 1.7 3.9 -0.0 -1.6 -0.8 -1.1 -0.0 -2.0 -1.6 -1.7
Bipolar Disorder or Schizophrenia 1.1 2.6 4.3 1.0 -2.0 -1.6 -1.7 -0.5 -1.4 -1.8 -2.1
Depressed Affect (Nagel 2018) 1.8 3.8 6.2 1.5 -2.1 -2.3 -2.4 -1.4 -0.6 -2.5 -2.2
Depression (Nagel 2018) 3.0 4.5 7.6 2.8 -1.8 -2.6 -2.8 -1.1 0.9 -2.1 -1.9
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.7 -0.8 0.6 0.6 0.4 -0.2 -0.3 0.3 0.6
Neuroticism (Nagel 2018) 2.3 5.4 8.5 2.0 -2.3 -2.8 -2.9 -2.0 -0.5 -2.8 -2.3
Schizophrenia (2018) 0.6 1.3 2.0 1.3 -1.3 -1.4 -1.3 -0.6 -0.2 -1.1 -1.3
Schizophrenia vs Biploar Disorder 0.3 0.4 0.9 0.9 -0.3 -0.8 -0.6 -0.5 0.7 -0.1 -0.3
Worry (Nagel 2018) 1.1 2.4 3.8 1.6 -1.6 -1.9 -1.9 -1.1 -0.3 -1.7 -1.6
Alzheimer’s Disease (in mother) 0.7 0.8 1.9 -1.4 0.8 0.8 0.8 0.8 0.8 0.7 0.8
Alzheimer’s Disease (in father) 0.2 0.2 0.3 -0.5 0.5 0.4 0.0 0.1 0.6 0.5 0.4
Alzheimer’s Disease (including proxy) 0.3 0.5 2.3 -1.5 0.5 0.7 0.4 0.3 0.4 0.5 0.4
Crohns Disease (2017) 0.1 0.2 1.2 -0.3 -0.3 0.0 0.5 -0.1 -1.1 -0.1 -0.3
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 0.3 -0.5 -0.3 -0.0 -0.2 -0.6 -0.3 -0.5
Ulcerative Colitis (UC) 0.2 0.4 1.4 1.2 -0.4 -0.7 -0.6 -0.3 0.4 -0.4 -0.4
Major Depression (MDD) 1.7 2.1 4.6 1.2 -1.3 -1.3 -1.5 -2.2 -1.0 -1.6 -1.3
Reaction Time 0.5 0.9 1.8 1.3 -0.1 -1.1 -1.2 -0.9 1.2 -0.5 -0.2
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.7 -1.3 0.8 1.2 1.2 0.7 -0.6 0.7 0.7
Breast Cancer 1.2 3.0 5.7 1.0 2.3 0.4 0.4 -1.8 2.4 1.6 2.3
Ovarian Cancer 0.9 1.2 1.8 0.6 -1.3 -1.1 -0.8 -1.2 -0.9 -1.2 -1.4
Prostate Cancer 0.3 0.4 1.9 -0.2 -0.7 -0.3 -0.2 0.5 -1.4 -0.4 -0.7
Age at First Birth 0.6 0.9 2.8 -1.5 0.2 0.9 0.8 1.7 -0.7 0.4 0.2
Bipolar Disorder (2011) 0.7 0.7 2.0 1.4 -0.3 -1.0 -1.2 -0.9 0.3 -0.5 -0.3
Body Mass Index (BMI) (2010) 0.6 0.8 1.8 -0.8 0.8 1.0 1.4 1.0 -0.2 1.0 0.8
Coronary Artery Disease (CAD) 0.2 0.2 1.3 -0.5 0.0 0.3 1.2 -0.3 -0.1 0.4 0.0
Crohns Disease (2012) 0.3 0.4 1.8 -0.7 -0.5 0.0 0.3 -0.6 -1.3 -0.4 -0.6
Mean Putamen Volume 0.3 0.3 1.6 1.3 -0.1 -0.7 -0.4 0.0 0.7 0.0 -0.0
Fasting Glucose 0.2 0.2 0.5 0.7 -0.3 -0.6 -0.4 -0.0 -0.0 -0.6 -0.4
HbA1C 0.3 0.4 0.7 -0.3 0.8 0.7 0.8 -0.0 0.4 0.6 0.8
HDL Cholesterol 0.2 0.4 2.5 -0.5 -0.0 -0.1 -0.1 1.6 0.5 0.2 -0.0
LDL Cholesterol 0.4 0.6 1.7 -1.3 0.2 0.8 1.3 0.4 -0.8 0.4 0.2
Lupus 0.6 0.9 3.1 1.8 -0.2 -0.9 -0.2 -1.7 -0.4 -0.1 -0.2
Neuroticism (2016) 5.6 8.0 10.5 2.7 -3.1 -3.2 -2.9 -2.6 -1.6 -3.2 -3.1
Primary Biliary Cirrhosis 1.8 2.5 3.6 -0.9 1.9 1.7 1.5 1.8 0.9 1.9 1.9
Rheumatoid Arthritis 0.3 0.4 0.6 0.7 -0.7 -0.7 -0.5 0.0 0.3 -0.7 -0.7
Schizophrenia (2014) 1.0 2.2 3.8 1.9 -1.7 -1.8 -1.4 -0.7 -0.6 -1.3 -1.8
Triglycerides 0.6 1.0 2.5 -0.6 1.2 1.2 1.6 -0.1 0.0 1.1 1.2
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.5 0.4 -1.0 -0.7 -0.6 -1.6 -1.2 -1.1 -0.9
Ulcerative Colitis 0.1 0.2 0.3 0.1 -0.5 -0.3 -0.3 -0.5 -0.4 -0.5 -0.5
Blood Eosinophil Count 0.1 0.7 1.2 1.0 -1.0 -1.0 -0.1 0.0 -1.0 -0.5 -1.1
Blood Platelet Count 0.1 1.4 3.6 -0.1 -1.9 -0.7 0.3 0.3 -1.6 -0.8 -1.8
Blood Red Count 1.1 10.6 56.6 -2.3 0.4 2.3 3.3 7.5 -0.5 2.5 0.4
Blood White Count 1.1 7.9 16.9 -0.1 -4.1 -1.8 -0.8 -0.2 -4.1 -2.9 -4.1
Heel T-Score 0.4 2.9 12.0 1.9 1.1 -1.0 -1.0 1.6 3.5 0.7 1.1
BMI 0.1 0.4 1.5 1.2 0.4 -0.4 -0.4 -0.9 0.4 0.0 0.3
Height 0.3 6.7 15.8 4.0 -2.1 -3.3 -2.5 -2.5 -0.9 -2.1 -2.1
Waist Hip Ratio (WHR) 0.3 1.2 2.6 -0.0 -1.6 -0.8 -0.7 -0.2 -1.5 -1.3 -1.5
Systolic Blood Pressure 0.5 2.3 4.2 2.0 -1.2 -1.9 -2.0 -1.3 -0.2 -1.3 -1.1
Smoking Status 0.1 0.1 0.3 -0.3 -0.3 0.2 0.0 -0.5 -0.4 -0.4 -0.4
Allergy or Eczema 0.4 1.0 3.4 0.1 0.9 0.5 0.7 1.9 0.7 1.1 0.9
Cardiovascular Disease 0.2 0.7 1.5 1.2 0.7 -0.3 -0.9 -0.7 1.0 0.2 0.7
Hypothyroidism (self reported) 1.7 3.9 7.5 2.7 -1.4 -2.5 -2.3 -2.2 -0.1 -1.7 -1.4
Respiratory disease 0.7 1.5 2.6 1.6 -1.4 -1.6 -1.0 0.4 -0.9 -1.0 -1.4
Type 2 Diabetes (T2D) (2018) 1.3 2.4 5.9 1.5 -1.3 -1.7 -1.2 -2.4 -1.1 -1.4 -1.3
Lung FEV1/FVC ratio 0.2 1.2 4.2 1.0 1.2 -0.3 -0.8 -0.0 2.1 0.5 1.2
Lung FVC 0.1 0.3 0.9 -1.0 0.4 0.6 -0.2 0.2 0.8 0.3 0.6
Neuroticism 1.1 2.7 4.9 2.0 -1.4 -2.2 -2.2 -0.7 0.7 -1.7 -1.5
Chronotype (morning person) 0.3 0.6 1.1 0.4 -0.8 -0.8 -0.6 -0.8 -0.8 -1.0 -0.8
Hair Pigment 0.1 3.9 5.6 2.0 -1.9 -2.3 -2.4 -2.3 -0.4 -2.0 -1.8
Tanning 0.1 1.2 3.4 -1.2 -1.2 0.0 0.2 0.6 -1.9 -1.1 -1.3
Hand grip strength (left) 0.3 0.8 1.3 -0.2 1.1 0.8 0.9 0.9 0.5 1.2 1.1
Number of treatments/medications taken 0.2 0.3 1.1 1.1 0.0 -0.3 -0.1 -0.9 0.4 -0.1 0.0
Average weekly spirits intake 0.5 0.7 1.8 0.5 -0.7 -0.8 -0.7 -1.3 -0.7 -0.8 -0.6
Sensitivity / hurt feelings 2.3 3.9 9.2 1.8 -1.7 -2.5 -3.0 -1.4 0.3 -2.3 -1.7
Frequency of depressed mood in last 2 weeks 4.7 6.5 10.8 2.9 -2.5 -3.3 -3.2 -1.3 0.0 -2.8 -2.5
Hearing difficulty/problems: Yes 0.5 0.8 2.7 0.5 -0.6 -0.8 -1.0 1.6 0.8 -0.5 -0.6
Relative age of first facial hair 0.5 1.1 2.4 1.2 1.3 0.1 -0.0 -0.2 1.6 1.0 1.4
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.5 0.6 0.2 -0.0 0.1 1.2 0.7 0.4 0.2
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.6 0.2 -0.8 -0.6 -0.5 -0.1 -0.6 -0.6 -0.8
Ever had hysterectomy (womb removed) 1.5 1.7 7.4 1.1 1.1 -0.4 -0.6 -1.1 2.7 0.6 1.2
Systolic blood pressure, automated reading 0.3 1.0 1.4 1.0 -1.1 -1.2 -1.2 -0.8 -0.5 -1.0 -1.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 1.1 -0.3 -0.4 0.3 0.4 -0.6 -1.0 -0.2 -0.3
Angina 1.0 1.3 1.9 1.0 -1.3 -1.4 -1.1 -0.7 -0.8 -1.3 -1.3
Medication for hormone replacement therapy 0.8 0.9 2.1 1.4 -1.0 -1.2 -0.9 -0.1 -0.0 -0.9 -1.0
Vitamin and mineral supplements 0.2 0.2 0.7 0.8 -0.0 -0.4 -0.2 -0.9 -0.4 0.1 0.0
Supplements: Zinc 2.5 2.7 5.8 -1.0 -2.1 -0.6 -0.5 -1.2 -2.4 -1.9 -2.1
Medication: Co-codamol 1.9 2.2 4.2 0.1 -1.7 -1.1 -1.2 -1.5 -2.0 -1.5 -1.8
Medication: Metformin 0.1 0.2 0.4 0.1 0.5 0.2 0.5 -0.7 0.1 0.5 0.6
Diabetes (father) 0.1 0.1 0.3 0.5 -0.1 -0.2 -0.1 -0.4 0.1 -0.1 -0.0
Diabetes (mother) 0.4 0.5 2.6 0.1 -0.4 -0.2 -0.0 -1.6 -1.1 -0.4 -0.3
Severe depression (siblings) 4.8 5.4 9.8 2.2 -2.0 -2.4 -3.1 -3.0 -0.5 -2.4 -1.9
Pack years adult smoking proportion 2.4 3.6 6.4 2.1 -2.0 -2.5 -2.2 -0.9 -0.7 -2.0 -2.0
Impedance of leg (right) 0.3 1.4 2.7 1.1 -1.2 -1.4 -1.7 1.1 0.2 -1.0 -1.1
Leg fat-free mass (left) 0.2 1.0 3.1 1.8 0.7 -0.3 0.3 -1.6 1.0 0.5 0.6
Trunk fat percentage 0.4 1.7 4.0 2.0 -1.0 -1.6 -1.2 -1.4 -0.2 -1.1 -1.1
Hand grip strength (right) 0.1 0.2 0.3 0.6 0.5 0.1 0.2 0.5 0.2 0.6 0.5
Townsend deprivation index at recruitment 0.5 0.7 1.6 1.3 -0.5 -1.0 -0.8 -1.1 0.2 -0.7 -0.5
Current tobacco smoking 0.3 0.4 0.8 0.7 -0.9 -0.5 -0.2 -0.1 -0.7 -0.7 -0.9
Average weekly fortified wine intake 1.9 2.2 4.2 1.7 -1.3 -2.0 -2.1 -0.6 0.4 -1.7 -1.3
Maternal smoking around birth 1.1 1.5 3.4 -0.3 -1.4 -0.4 -0.4 -1.7 -1.9 -1.4 -1.4
Fed-up feelings 1.6 2.8 4.9 1.8 -1.2 -1.9 -2.1 -2.2 0.1 -1.9 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.9 3.9 8.2 2.9 -1.6 -2.6 -2.5 -1.0 0.5 -1.8 -1.6
Relative age voice broke 1.2 1.8 3.7 0.5 1.9 0.8 0.6 0.6 1.7 1.7 1.9
Taking other prescription medications 0.2 0.4 1.1 1.0 0.0 -0.5 -0.4 -0.6 1.0 -0.1 0.0
Age when periods started (menarche) 0.1 0.2 0.4 0.4 -0.1 -0.7 -0.6 0.5 0.2 -0.3 -0.2
Bilateral oophorectomy (both ovaries removed) 3.6 4.1 9.6 3.1 -0.7 -2.6 -2.2 -2.6 1.6 -1.1 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 5.1 0.6 1.2 0.1 -0.2 0.7 2.3 0.9 1.3
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.6 -1.3 0.9 1.1 0.6 1.0 0.1 0.8 0.8
Qualifications: CSEs or equivalent 0.8 1.0 3.0 0.3 -0.5 -0.9 -1.4 -1.7 -0.4 -1.2 -0.5
Serious illness, injury or assault to yourself 2.0 2.5 5.4 2.0 -0.9 -2.1 -2.3 -1.5 0.5 -1.4 -0.9
High blood pressure 0.8 2.3 6.5 2.6 -0.8 -1.8 -2.0 -1.3 0.8 -1.1 -0.8
Hayfever, allergic rhinitis or eczema 1.5 3.2 6.6 -0.7 1.9 1.5 1.6 2.6 1.4 2.0 2.0
Multivitamins +/- minerals 0.2 0.3 0.6 -0.7 -0.6 -0.1 -0.4 -0.1 -0.3 -0.8 -0.7
Stomach or abdominal pain in last month 0.2 0.2 0.3 -0.3 0.5 0.4 0.3 -0.5 -0.4 0.4 0.6
Supplements: Glucosamine 0.7 0.9 2.1 -1.5 0.8 1.1 1.2 0.5 -0.4 0.8 0.8
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.2 0.6 -0.3 -0.0 0.3 -0.3 -1.1 0.0 -0.3
Medication: Atenolol 0.2 0.2 0.9 -0.9 -0.4 0.3 0.3 -0.4 -0.3 -0.4 -0.3
Medication: Levothyroxine sodium 0.3 0.5 1.8 1.3 0.7 -0.3 -0.2 -0.5 0.9 0.5 0.6
Sitting height 0.1 0.5 1.1 0.3 0.7 0.4 0.7 0.4 1.0 1.0 0.7
Chronic bronchitis/emphysema (father) 0.5 0.6 1.8 1.3 0.1 -0.6 -0.3 -1.3 1.0 -0.0 0.0
High blood pressure (mother) 0.6 0.8 1.8 0.1 1.2 0.7 0.8 -0.4 1.0 1.0 1.3
Body mass index (BMI) 0.2 1.0 3.2 1.8 0.1 -0.8 -0.6 -1.7 0.7 -0.3 0.0
Impedance of leg (left) 0.5 2.3 4.2 1.5 -1.6 -2.0 -2.0 1.0 0.1 -1.4 -1.5
Leg predicted mass (left) 0.2 1.0 3.3 1.8 0.7 -0.4 0.3 -1.6 1.0 0.5 0.6
Trunk fat mass 0.4 1.7 5.0 2.2 -0.8 -1.6 -1.1 -1.6 -0.0 -1.0 -0.9
Waist circumference 0.6 2.4 5.3 2.3 -1.2 -1.8 -1.2 -1.9 -0.5 -1.4 -1.3
Number of incorrect matches in round 0.3 0.4 1.6 -1.0 -0.5 -0.0 0.1 -0.3 -1.3 -0.5 -0.6
Past tobacco smoking 0.4 0.8 1.4 0.1 -1.1 -0.9 -0.7 0.3 -1.2 -1.0 -1.1
Alcohol usually taken with meals 0.1 0.2 0.4 -0.7 0.5 0.4 -0.0 0.4 0.3 0.2 0.4
Nervous feelings 0.8 1.4 2.8 0.7 -1.3 -1.4 -1.7 -0.8 -0.6 -1.4 -1.2
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 4.8 1.0 -2.1 -1.8 -1.5 -0.5 -1.1 -1.9 -2.2
Hearing difficulty/problems with background noise 0.9 1.4 2.6 0.6 -1.6 -1.2 -1.1 1.3 0.1 -1.3 -1.6
Hair/balding pattern: Pattern 2 0.1 0.1 0.3 -0.5 -0.1 0.3 0.2 -0.5 0.1 -0.1 -0.1
Had menopause 0.4 0.5 0.9 -0.3 0.8 0.8 0.9 0.3 0.0 0.9 0.7
Had other major operations 0.1 0.1 0.4 -0.7 -0.2 0.0 -0.1 0.3 -0.5 -0.0 -0.2
Forced vital capacity (FVC) 0.2 0.6 1.8 1.1 -0.0 -0.9 -1.3 -0.1 1.0 -0.2 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.6 1.4 -0.1 -1.3 -1.6 -0.8 1.4 -0.5 -0.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 1.4 -0.7 -0.9 -0.2 -0.7 -0.7 -1.2 -1.0 -0.9
Qualifications: None of the above 2.4 5.2 7.6 2.2 -2.8 -2.5 -1.9 -1.8 -1.5 -2.6 -2.7
Financial difficulties in last 2 years 0.7 1.0 1.7 0.3 -1.2 -1.1 -1.2 -0.9 -0.4 -1.3 -1.1
Mouth/teeth dental problems 0.7 1.1 2.0 -1.4 0.7 1.3 1.3 0.4 -1.2 0.8 0.6
Heart attack 3.7 4.7 6.6 0.9 -2.5 -1.9 -1.7 -2.5 -2.2 -2.5 -2.6
Allergy 0.3 0.6 2.7 -0.1 -0.5 -0.6 -0.8 -1.7 -0.1 -0.8 -0.6
Pain all over the body in last month 1.3 1.4 3.9 2.0 -0.4 -1.6 -1.2 -0.5 1.4 -0.6 -0.5
Diabetes (self-reported) 3.0 4.6 8.3 1.6 -2.3 -2.1 -1.6 -2.9 -2.0 -2.1 -2.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 0.1 -0.3 -0.5 -0.3 0.3 -0.5 -0.4 -0.3
Medication: Ramipril 0.7 0.9 5.6 0.8 0.2 -0.5 -0.8 -2.4 0.3 -0.3 0.1
Medication: Simvastatin 0.2 0.4 1.1 0.7 0.6 0.0 0.3 0.1 1.1 0.6 0.6
Fluid intelligence score 0.4 0.8 1.9 -1.2 0.2 1.1 1.4 0.7 -1.2 0.3 0.1
Illnesses of siblings 0.0 0.1 0.2 0.4 0.1 -0.2 -0.4 -0.1 0.2 -0.1 0.0
Neuroticism score 1.9 4.0 7.2 2.3 -1.9 -2.7 -2.5 -0.7 0.5 -2.2 -1.9
Weight 0.3 1.7 7.1 2.7 -0.1 -1.3 -0.7 -1.8 0.9 -0.4 -0.2
Impedance of arm (right) 0.2 1.1 2.0 0.2 -1.3 -1.1 -1.4 0.2 -0.4 -1.3 -1.2
Arm fat percentage (right) 0.2 0.9 2.2 1.5 -0.4 -1.1 -0.8 -1.4 0.4 -0.8 -0.5
Trunk fat-free mass 0.2 1.0 3.1 1.8 0.8 -0.2 0.4 -1.0 1.4 0.7 0.7
Hip circumference 0.1 0.5 2.1 1.5 0.2 -0.5 -0.1 -1.1 0.5 -0.0 0.1
Time employed in main current job 0.7 0.8 1.7 -0.7 0.8 0.8 0.9 1.3 0.7 0.8 0.8
Alcohol intake versus 10 years previously 1.1 1.6 4.0 2.0 -0.6 -1.6 -1.7 -1.0 0.9 -1.0 -0.5
Father’s age at death 1.9 2.6 3.7 -1.3 1.7 1.8 1.6 1.9 1.2 1.7 1.6
Worrier / anxious feelings 1.2 2.4 4.0 1.8 -1.6 -2.0 -1.9 -0.6 0.2 -1.6 -1.6
Frequency of tiredness / lethargy in last 2 weeks 6.1 9.8 14.3 2.5 -3.8 -3.7 -3.2 -2.0 -1.9 -3.6 -3.8
Falls in the last year 0.3 0.4 1.0 1.0 0.6 -0.3 -0.4 -0.2 1.0 0.1 0.5
Hair/balding pattern: Pattern 3 0.1 0.1 0.5 -0.1 -0.3 -0.1 0.2 0.2 -0.7 -0.1 -0.2
Number of live births 0.7 0.9 2.6 -1.6 0.0 1.2 1.3 0.4 -1.0 0.7 0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.0 1.1 0.3 -0.8 -1.3 0.1 1.4 -0.0 0.4
Pulse rate 1.3 2.2 3.6 1.9 -1.6 -1.9 -1.3 -1.2 -0.4 -1.5 -1.5
Happiness 0.6 0.7 1.5 0.7 -1.2 -1.0 -0.3 0.4 -0.2 -0.9 -1.2
Noisy workplace 0.2 0.2 0.9 0.7 0.1 -0.3 -0.5 0.1 1.0 -0.1 -0.0
Qualifications: A levels/AS levels or equivalent 1.2 2.6 4.0 -0.9 1.6 1.8 1.9 2.0 0.7 1.9 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.8 0.3 -0.7 -0.8 -0.9 -0.2 -0.6 -0.7 -0.7
Mouth/teeth dental problems: Dentures 0.2 0.4 1.4 1.2 -0.1 -0.7 -0.6 -0.1 0.9 -0.2 -0.0
Asthma 0.1 0.2 1.1 1.0 -0.3 -0.6 -0.0 -0.2 0.1 -0.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 3.9 4.9 7.8 -1.0 2.1 2.3 2.8 2.3 2.1 2.6 2.2
Medication: Cholesterol lowering 0.9 1.4 2.4 0.9 -1.1 -1.1 -1.3 -1.6 -0.9 -1.3 -1.1
Depression (self-reported) 0.9 1.1 1.9 -0.0 -1.3 -0.6 -0.9 -1.3 -0.8 -1.4 -1.2
Medication: Lansoprazole 0.2 0.2 0.5 0.2 -0.7 -0.4 -0.3 -0.1 0.1 -0.6 -0.7
Prospective memory result 0.3 0.4 1.6 0.1 0.5 0.1 -0.8 0.5 1.3 0.2 0.5
Lung cancer (father) 2.5 2.9 5.3 1.6 -1.4 -2.1 -2.3 -1.6 0.3 -2.0 -1.5
Illnesses of mother 0.1 0.1 0.6 -0.0 -0.4 -0.0 0.2 0.1 -0.8 -0.2 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 5.4 1.0 1.1 -0.3 -0.9 0.5 2.3 0.7 1.2
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 -0.3 -0.6 -0.0 0.1 -0.6 -0.6 -0.4 -0.6
Impedance of arm (left) 0.4 1.8 3.6 -0.4 -1.9 -1.0 -1.0 0.6 -1.6 -1.5 -1.8
Arm fat mass (right) 0.3 1.3 4.8 2.2 0.0 -1.2 -0.8 -1.5 1.0 -0.4 -0.1
Trunk predicted mass 0.2 1.0 3.3 1.8 0.7 -0.3 0.4 -1.0 1.4 0.6 0.7
Standing height 0.1 0.7 4.2 2.0 -0.3 -1.0 -0.3 -0.4 0.5 0.0 -0.3
Length of working week for main job 3.8 4.2 13.7 3.7 0.3 -2.2 -2.3 0.2 3.1 -0.3 0.1
Exposure to tobacco smoke at home 0.3 0.3 0.6 -0.7 -0.5 0.1 -0.3 0.7 -0.8 -0.4 -0.5
Breastfed as a baby 3.3 4.2 5.4 -1.9 2.2 2.3 1.8 2.1 1.3 2.1 2.2
Tense / ‘highly strung’ 0.7 1.1 2.7 1.6 -0.2 -1.4 -1.5 0.2 1.3 -0.5 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.5 1.0 -0.5 -1.0 -1.2 -0.7 1.2 -0.9 -0.5
Hair/balding pattern: Pattern 4 0.2 0.5 2.0 -1.1 -0.6 0.1 -0.0 -0.2 -1.4 -0.4 -0.7
Birth weight of first child 0.0 0.0 0.1 0.4 -0.1 -0.1 -0.0 0.3 -0.0 -0.0 -0.1
Peak expiratory flow (PEF) 0.3 0.7 2.4 0.5 0.9 -0.4 -1.6 -0.2 1.3 0.0 0.8
Pulse wave reflection index 1.5 1.8 3.0 -1.0 1.6 1.4 0.9 0.6 1.7 1.4 1.7
Ever highly irritable/argumentative for 2 days 4.1 4.9 7.1 1.0 -2.5 -2.2 -2.3 -2.6 -1.6 -2.7 -2.4
Loud music exposure frequency 0.3 0.3 1.0 -1.0 -0.1 0.4 0.4 0.9 -0.3 0.2 -0.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 2.8 -1.4 1.0 1.6 1.7 1.3 -0.1 1.5 1.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 0.2 -0.9 -0.7 -0.9 -0.2 0.2 -0.9 -0.8
Blood clot in the leg (DVT) 0.2 0.2 0.7 0.4 0.4 0.4 0.2 0.4 0.9 0.5 0.5
Medication: Paracetamol 0.1 0.2 0.6 -0.1 0.3 0.2 0.3 0.6 0.8 0.5 0.4
Headache pain in last month 0.4 0.7 1.5 0.5 -0.9 -0.9 -1.2 -0.3 -0.5 -1.0 -0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.6 -1.5 -0.2 0.7 0.9 1.6 -0.4 0.2 -0.1
Glaucoma (self-reported) 0.5 0.6 2.2 -0.9 -0.1 0.7 1.2 1.5 -0.3 0.3 -0.1
Gout (self-reported) 1.0 1.4 3.4 0.7 1.3 0.4 1.0 0.9 1.8 1.5 1.3
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 4.6 2.1 -0.2 -1.4 -1.3 -1.1 0.8 -0.6 -0.2
Medication: Amlodipine 0.7 1.0 2.5 0.8 -0.9 -1.0 -1.0 -1.6 -0.6 -1.1 -0.9
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.1 1.0 0.7 0.1 0.6 0.6 0.8 0.9 0.7
Birth weight 1.7 3.7 6.4 -1.4 2.0 2.3 2.5 1.8 0.6 2.3 2.0
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.8 1.3 -0.4 -1.4 -1.7 -0.5 0.7 -0.8 -0.3
High blood pressure (siblings) 0.6 0.8 1.4 -0.1 -1.0 -0.6 -1.2 -0.8 -1.1 -1.1 -0.9
Forced vital capacity (FVC), Best measure 0.3 1.0 3.9 1.2 0.8 -0.4 -0.8 0.2 2.0 0.6 0.9
Body fat percentage 0.4 1.7 4.1 2.0 -0.9 -1.6 -1.2 -1.4 -0.1 -1.1 -1.0
Leg fat percentage (right) 0.4 1.3 2.9 1.7 -0.8 -1.4 -1.2 -1.3 -0.1 -1.1 -0.9
Arm fat-free mass (right) 0.2 0.9 3.5 1.9 0.7 -0.2 0.6 -0.8 1.0 0.8 0.7
Exposure to tobacco smoke outside home 0.0 0.0 0.2 -0.2 0.2 0.2 0.1 -0.4 -0.1 0.1 0.3
Comparative body size at age 10 0.9 2.5 4.6 -2.0 1.8 2.2 1.8 0.1 0.4 1.4 1.7
Number of full brothers 0.2 0.3 0.6 0.1 0.5 0.2 0.3 0.7 0.5 0.8 0.6
Worry too long after embarrassment 1.4 2.3 4.0 1.0 -1.8 -1.7 -1.8 0.3 0.2 -2.0 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 5.0 2.0 0.5 -1.1 -1.9 -0.3 2.2 -0.2 0.5
Wheeze or whistling in the chest in last year 0.2 0.4 2.5 1.6 -0.4 -0.7 -0.1 0.3 -0.1 -0.2 -0.5
Number of children fathered 0.2 0.2 0.5 0.6 -0.3 -0.7 -0.7 0.3 -0.5 -0.2 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.7 -0.4 -0.8 -0.2 -0.3 -0.2 -0.7 -0.6 -0.8
Age at first live birth 0.1 0.1 0.7 0.2 0.1 -0.1 -0.3 0.4 0.9 0.1 0.2
Pulse wave peak to peak time 0.1 0.1 0.2 0.5 0.3 -0.2 -0.3 0.3 0.3 0.1 0.2
Health satisfaction 0.9 1.2 2.9 0.4 -1.3 -0.9 -0.1 -0.9 -1.7 -1.1 -1.4
Shortness of breath walking on level ground 0.6 0.8 1.0 0.9 -1.0 -1.0 -0.9 -0.1 -0.8 -1.0 -1.0
Qualifications: College or University degree 1.4 4.3 11.9 -1.9 1.7 2.1 1.9 3.4 0.7 2.1 1.6
Eye problems/disorders: None of the above 1.7 1.9 3.7 1.2 -1.0 -1.8 -1.9 -1.6 -0.0 -1.5 -1.1
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 -0.2 0.1 0.2 0.1 -0.1 -0.0 -0.1 0.1
Emphysema/chronic bronchitis 0.8 0.9 2.4 1.5 -0.6 -1.3 -1.3 0.3 -0.2 -0.6 -0.6
Medication for pain relief, constipation, heartburn 0.1 0.2 0.5 0.5 0.7 -0.1 -0.2 -0.4 0.7 0.3 0.6
Neck or shoulder pain in last month 0.1 0.1 0.3 -0.1 -0.3 0.0 -0.5 -0.5 -0.3 -0.3 -0.3
Medication: Blood pressure 0.6 1.0 3.4 1.6 -0.1 -0.9 -1.0 -1.9 0.3 -0.4 -0.1
Angina (self-reported) 1.1 1.5 2.2 1.0 -1.4 -1.4 -1.2 -0.7 -0.9 -1.4 -1.5
Migraine (self-reported) 0.8 1.0 1.4 1.0 -1.0 -1.1 -1.1 -1.0 -0.3 -1.2 -1.1
Medication: Ibuprofen 4.0 4.7 7.0 -0.4 2.2 1.9 2.3 2.3 2.6 2.6 2.3
Medication: Allopurinol 1.8 2.4 4.5 -0.3 1.9 1.1 1.1 1.6 2.1 1.8 1.8
Medication: Omeprazole 1.9 2.3 3.6 -0.3 -1.8 -1.1 -1.4 -1.0 -1.9 -1.9 -1.9
Medication: Seretide 50 evohaler 0.0 0.0 0.1 -0.0 -0.0 0.2 0.3 0.1 -0.2 0.1 -0.0
Mean time to correctly identify matches 0.2 0.3 0.6 0.6 -0.2 -0.7 -0.8 -0.6 0.5 -0.4 -0.3
Heart disease (mother) 0.2 0.2 0.8 0.4 0.5 -0.0 -0.0 -0.3 0.9 0.2 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.2 0.5 -1.5 -1.1 -0.9 -0.0 -0.7 -1.3 -1.5
Whole body fat mass 0.4 1.7 5.7 2.4 -0.5 -1.5 -1.0 -1.7 0.4 -0.8 -0.6
Leg fat mass (right) 0.4 1.5 5.9 2.4 -0.2 -1.4 -1.1 -1.3 0.9 -0.6 -0.3
Arm predicted mass (right) 0.2 0.9 3.6 1.9 0.6 -0.3 0.5 -1.0 0.9 0.7 0.5
Pulse rate, automated reading 0.3 0.8 1.4 1.0 -1.0 -1.2 -1.1 0.4 -0.1 -0.9 -1.0
Alcohol intake frequency. 0.6 1.4 2.5 1.6 -0.3 -1.4 -1.5 -1.5 1.0 -0.9 -0.3
Comparative height size at age 10 0.1 0.5 1.2 -0.7 0.5 0.9 1.1 0.0 0.0 0.9 0.6
Number of full sisters 0.9 1.1 2.8 1.7 -0.9 -1.4 -1.3 -0.6 -0.2 -0.8 -0.8
Suffer from ‘nerves’ 0.2 0.3 1.1 -0.4 0.3 0.4 0.7 1.1 0.3 0.5 0.3
Overall health rating 1.1 2.5 7.0 2.7 -1.4 -2.1 -1.5 -0.1 0.5 -1.3 -1.5
Chest pain or discomfort 1.0 1.4 2.2 1.2 -1.4 -1.3 -1.2 0.6 -0.3 -1.4 -1.5
Had major operations 1.5 1.8 2.7 -0.2 1.5 1.4 1.1 1.6 1.2 1.5 1.6
Age at last live birth 0.0 0.1 0.2 -0.5 0.1 0.1 -0.0 0.2 0.2 0.3 0.2
Family relationship satisfaction 4.8 5.9 9.5 1.7 -2.4 -2.8 -3.0 -2.4 -0.6 -3.1 -2.4
Leg pain on walking 3.2 4.0 5.5 1.2 -2.0 -2.1 -2.3 -2.3 -1.4 -2.3 -2.0
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.0 -1.0 0.6 1.0 0.6 0.4 0.1 0.5 0.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.3 0.4 -0.1 -0.3 -0.3 0.6 0.1 0.3
Illness, injury, bereavement, stress in last 2 years 4.1 5.0 10.2 -2.1 2.2 2.7 3.2 1.3 0.2 2.6 2.1
Medication: Aspirin 1.8 2.3 4.2 0.4 -1.9 -1.2 -1.1 -1.3 -2.0 -1.8 -1.8
Supplements: Vitamin C 0.4 0.4 1.9 -0.9 0.1 0.7 0.5 1.4 0.1 0.2 -0.0
Knee pain experienced in last month 1.5 2.3 4.9 2.2 -1.5 -2.0 -1.8 -0.1 -0.2 -1.4 -1.5
Hypertension (Self-reported) 0.7 2.1 6.6 2.6 -0.6 -1.8 -1.8 -1.3 0.9 -0.8 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 7.5 8.8 15.4 0.8 -3.9 -2.7 -2.5 -2.2 -2.7 -3.6 -3.8
Illnesses of father: Heart disease 1.2 1.7 3.0 0.1 -1.6 -1.0 -1.1 -1.1 -1.7 -1.3 -1.7
Illnesses of siblings: Diabetes 0.2 0.2 0.5 0.3 -0.7 -0.5 0.4 0.3 -0.5 -0.1 -0.7
Smoking status: Previous 0.5 0.8 1.6 -0.4 1.2 1.0 0.6 -0.3 0.9 1.0 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.0 1.3 0.6 -0.7 -0.7 -0.3 1.7 0.4 0.6
Whole body fat-free mass 0.2 1.2 4.2 2.1 0.7 -0.5 0.2 -1.4 1.4 0.6 0.7
Leg fat-free mass (right) 0.2 1.0 3.5 1.9 0.6 -0.5 0.2 -1.6 1.0 0.4 0.5
Arm fat percentage (left) 0.2 0.9 1.9 1.2 -0.7 -1.1 -0.7 -1.4 -0.3 -1.0 -0.8
Average weekly red wine intake 0.8 1.2 3.6 -1.9 0.1 1.1 1.4 1.0 -1.3 0.6 0.1
Handedness (chirality/laterality): Left-handed 2.0 2.4 5.0 -1.3 1.3 1.6 2.2 1.5 0.7 1.7 1.4
Mood swings 2.4 4.3 7.5 2.4 -2.0 -2.7 -2.6 -1.2 0.1 -2.2 -2.0
Loneliness, isolation 3.5 4.8 7.7 1.4 -2.8 -2.4 -2.2 -1.0 -1.9 -2.5 -2.8
Long-standing illness, disability or infirmity 0.4 0.6 1.3 0.5 -1.1 -0.6 -0.1 0.9 -0.5 -0.6 -1.1
Ever had bowel cancer screening 0.9 1.0 2.5 -0.2 1.3 1.0 0.4 0.5 1.6 1.0 1.3
Diabetes diagnosed by doctor 1.5 2.5 5.8 1.9 -1.2 -1.8 -1.4 -2.4 -0.5 -1.4 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.6 -1.3 0.5 0.8 0.6 0.0 0.3 0.4 0.4
Friendships satisfaction 0.2 0.2 1.2 -0.2 0.2 0.2 0.5 1.1 0.4 0.2 0.1
Qualifications: nursing, teaching 2.0 3.1 6.2 -0.9 1.6 1.8 1.8 2.5 1.3 2.0 1.7
Commuting to job workplace: Walk 0.3 0.4 0.7 0.8 -0.2 -0.7 -0.6 -0.8 0.7 -0.5 -0.2
Eye problems/disorders: Cataract 0.2 0.2 0.6 -0.7 -0.3 0.5 0.3 0.6 -0.8 -0.1 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 3.0 0.7 0.9 -0.0 -0.2 0.4 1.7 0.7 1.0
Medication for cholesterol 0.1 0.2 0.6 -0.7 0.3 0.5 0.3 0.1 -0.5 0.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.9 -0.5 -0.6 -0.0 0.3 -0.7 -1.0 -0.5 -0.6
Back pain experienced in last month 0.1 0.2 0.4 -0.6 0.3 0.7 0.4 0.7 0.2 0.2 0.2
Mineral and other dietary supplements 0.4 0.6 2.2 1.5 -0.5 -0.9 -0.8 -0.1 0.5 -0.3 -0.4
Breast cancer (self-reported) 0.3 0.4 1.4 1.2 -0.3 -0.7 -0.8 0.3 0.3 -0.2 -0.2
Asthma (self-reported) 0.1 0.2 1.3 1.2 -0.2 -0.6 -0.0 0.0 0.3 -0.1 -0.2
Osteoporosis (self-reported) 0.8 1.0 3.2 1.4 0.5 -0.7 -1.1 0.4 1.8 0.3 0.6
Osteoarthritis (self-reported) 0.8 1.1 1.8 1.3 -0.9 -1.3 -1.2 0.7 1.0 -0.8 -0.9
Medication: Aspirin 3.3 4.3 8.0 0.2 -2.6 -1.5 -1.3 -1.7 -2.8 -2.4 -2.6
Medication: Gliclazide 1.0 1.1 5.4 0.5 -0.7 -0.8 -0.6 -2.3 -0.7 -0.9 -0.6
Illnesses of father: None of the above (group 1) 0.3 0.4 1.1 -0.4 0.5 0.6 1.0 0.8 -0.1 0.5 0.5
Smoking status: Current 0.3 0.4 0.9 0.1 -0.9 -0.2 0.1 0.1 -1.0 -0.6 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 3.6 -1.0 1.9 1.1 0.1 0.8 1.3 1.5 1.9
Whole body water mass 0.2 1.1 3.8 1.9 0.7 -0.4 0.3 -1.4 1.3 0.6 0.7
Leg predicted mass (right) 0.2 1.0 3.6 1.9 0.6 -0.5 0.2 -1.6 1.0 0.4 0.5
Arm fat mass (left) 0.2 1.0 3.8 2.0 -0.1 -1.0 -0.5 -1.4 0.7 -0.4 -0.2
Number of self-reported non-cancer illnesses 0.5 0.9 2.6 1.6 -0.0 -0.8 -1.1 0.1 1.5 -0.3 0.0
Average weekly champagne plus white wine intake 0.6 0.8 2.7 -0.4 -1.1 -0.3 0.2 -0.5 -1.6 -0.9 -1.2
Miserableness 0.8 1.3 2.2 0.8 -1.5 -1.4 -1.1 -0.4 -0.6 -1.4 -1.5
Guilty feelings 0.8 1.2 2.1 1.1 -1.1 -1.4 -1.4 0.3 0.4 -1.2 -1.2
Wears glasses or contact lenses 0.3 0.3 0.8 -0.1 -0.9 -0.3 -0.4 0.1 -0.6 -0.6 -0.9
Ever taken oral contraceptive pill 0.9 1.0 3.0 0.2 1.3 0.6 0.2 0.5 1.7 1.0 1.3
Hearing aid user 0.3 0.4 1.1 -0.6 -0.6 -0.1 -0.6 -0.0 -1.1 -0.5 -0.6
Mother’s age at death 0.6 0.8 1.2 0.4 -1.0 -1.1 -1.0 -0.7 -0.8 -1.1 -0.9
Financial situation satisfaction 2.6 3.2 4.9 1.5 -2.2 -2.1 -1.9 -0.9 -0.4 -2.1 -2.2
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.3 -1.2 0.5 1.0 0.8 1.0 -0.2 0.6 0.5
Commuting to job workplace: Public transport 0.5 0.6 0.9 0.6 -0.6 -0.7 -0.9 -1.0 -0.6 -0.8 -0.7
Eye problems/disorders: Glaucoma 0.7 0.8 2.4 -1.1 -0.2 0.8 1.4 1.6 -0.5 0.4 -0.1
Medication: Blood pressure 1.0 1.9 2.9 1.4 -1.7 -1.7 -1.4 -0.7 -0.5 -1.4 -1.7
Pain type(s) experienced in last month: Hip pain 1.3 1.6 3.4 0.3 -1.8 -1.2 -0.6 -0.9 -1.1 -1.5 -1.9
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.3 -0.6 0.6 0.4 0.5 -0.1 0.3 0.5 0.5
High cholesterol (Self-reported) 0.1 0.1 0.4 0.2 -0.2 -0.3 -0.5 -0.4 -0.1 -0.6 -0.2
Medication: Bendroflumethiazide 0.1 0.2 0.6 0.4 -0.3 -0.3 -0.5 -0.8 -0.3 -0.3 -0.4
Medication: Paracetamol 0.6 1.0 1.4 -1.0 0.8 1.1 1.1 1.2 0.7 1.1 0.9
Medication: Lisinopril 0.9 1.2 4.9 2.2 0.4 -1.0 -0.5 -0.6 1.6 0.3 0.5
Medication: Atorvastatin 3.5 4.3 7.8 1.2 -2.3 -1.8 -1.9 -1.6 -2.8 -2.3 -2.4
Illnesses of father: High blood pressure 0.2 0.2 1.0 0.0 0.4 0.3 -0.0 1.0 0.6 0.5 0.4
Alcohol drinker status: Never 0.5 0.6 2.3 0.1 1.0 0.1 0.3 -0.0 1.5 0.8 0.9
Ever smoked 0.4 0.6 1.8 1.3 0.7 -0.1 0.3 -0.2 1.3 0.7 0.7
Basal metabolic rate 0.2 1.3 5.2 2.3 0.6 -0.6 0.1 -1.4 1.4 0.4 0.5
Leg fat percentage (left) 0.6 2.1 4.5 2.1 -1.1 -1.8 -1.6 -1.4 -0.1 -1.4 -1.2
Arm fat-free mass (left) 0.3 1.8 5.1 2.3 1.2 -0.4 0.3 -1.1 2.1 0.9 1.1
Number of operations (self-reported) 0.4 0.6 1.3 1.0 -0.4 -1.0 -1.1 -0.7 0.2 -0.6 -0.3
Average weekly beer plus cider intake 1.2 1.8 4.2 1.8 -0.9 -1.6 -1.2 -2.1 0.0 -1.1 -0.8
Irritability 0.4 0.7 1.7 1.3 -0.6 -1.2 -0.9 -0.7 0.2 -0.8 -0.7
Risk taking 0.3 0.4 1.1 0.8 0.8 -0.2 -0.7 -0.0 1.0 0.3 0.7
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.5 -1.0 1.0 1.2 1.2 1.1 0.6 1.2 0.9
Fractured/broken bones in last 5 years 0.6 0.8 1.7 1.2 -0.4 -1.0 -1.3 -0.7 1.0 -0.6 -0.4
Age started oral contraceptive pill 1.8 2.2 4.5 -0.1 1.8 1.1 0.8 2.1 1.6 1.8 1.7
Diastolic blood pressure, automated reading 1.1 3.3 6.1 2.3 -1.7 -2.5 -2.2 -0.5 0.2 -1.9 -1.8
Ever depressed for a whole week 1.1 1.4 3.3 -0.6 -1.3 -0.8 -1.1 -0.3 -1.8 -1.5 -1.4
Unable to work because of sickness or disability 1.6 2.1 4.2 1.9 -1.2 -2.0 -1.6 -1.0 0.4 -1.4 -1.2
Commuting to job workplace: Cycle 3.3 3.9 6.7 0.8 -2.5 -2.0 -1.3 -1.0 -2.4 -2.3 -2.6
Myopia 0.7 0.9 2.0 -1.4 0.6 1.1 1.4 0.7 -0.4 0.9 0.6
Vascular/heart problems diagnosed by doctor 1.4 3.9 10.0 -3.2 1.2 2.4 2.5 1.9 -0.5 1.6 1.3
Cholesterol lowering medication 0.1 0.1 0.2 0.4 -0.4 -0.3 0.2 0.1 -0.0 -0.3 -0.4
Medication: Omeprazole (e.g. Zanprol) 2.3 2.8 4.7 0.1 -2.0 -1.4 -1.8 -1.0 -1.8 -2.2 -2.0
Pain experienced in last month 0.0 0.1 0.3 -0.0 0.2 0.3 0.6 0.0 -0.1 0.2 0.2
Supplements: Calcium 0.4 0.5 1.7 0.6 0.1 -0.6 -0.9 -1.3 0.5 -0.5 0.1
Basal cell carcinoma (self-reported) 1.4 1.6 3.7 -1.9 1.1 1.7 1.5 0.7 -0.2 1.2 1.2
Heart attack/myocardial infarction (self-reported) 3.1 3.9 6.1 0.6 -2.4 -1.6 -1.3 -2.1 -2.3 -2.3 -2.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.4 0.0 0.4 0.7 0.2 0.3 0.6 0.5 0.5
Heart disease (siblings) 0.3 0.4 0.9 0.6 0.7 0.2 0.1 -0.9 1.0 0.4 0.7
Alcohol drinker status: Previous 0.4 0.4 2.0 -0.2 -0.5 0.3 0.7 0.3 -1.4 -0.0 -0.5
Pack years of smoking 2.7 4.0 6.9 2.3 -2.0 -2.6 -2.3 -1.1 -0.7 -2.0 -2.1
Impedance of whole body 0.4 1.9 3.4 0.4 -1.8 -1.5 -1.6 0.7 -1.0 -1.5 -1.8
Leg fat mass (left) 0.5 2.0 8.1 2.8 -0.3 -1.7 -1.3 -1.5 0.9 -0.7 -0.4
Arm predicted mass (left) 0.3 1.7 5.0 2.2 1.2 -0.3 0.4 -1.1 2.0 1.0 1.1