[Hub]/) : Traits : Blood Red Count :

chr9:3,855,616-7,368,850

Best TWAS P=1.57e-42 · Best GWAS P=1.61e-105 conditioned to 3.28e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex IL33 0.09 0.07 bslmm 453 0.08 1.7e-09 -8.1 -8.5 2.2e-17 -0.03 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex JAK2 0.09 0.02 lasso 5 0.03 1.0e-04 13.2 -9.9 2.5e-23 -0.53 0.73 0.06 FALSE
3 CommonMind Brain Pre-frontal Cortex RCL1 0.10 0.07 bslmm 632 0.05 4.2e-07 13.1 13.7 1.6e-42 0.70 0.60 0.39 TRUE
4 GTEx Brain Cerebellum SPATA6L 0.41 0.01 lasso 7 0.09 1.7e-03 7.5 7.0 2.4e-12 0.06 0.15 0.05 TRUE
5 GTEx Breast Mammary Tissue SPATA6L 0.30 0.13 lasso 2 0.15 5.7e-08 9.5 8.8 1.4e-18 0.11 1.00 0.00 FALSE
6 GTEx Breast Mammary Tissue (Female) SPATA6L 0.31 0.07 lasso 4 0.07 4.4e-03 5.9 8.4 3.7e-17 0.09 0.13 0.05 FALSE
7 GTEx Cells Transformed fibroblasts AK3 0.15 0.07 lasso 6 0.04 3.9e-04 -1.9 5.3 1.2e-07 0.13 0.71 0.18 TRUE
8 GTEx Colon Transverse SPATA6L 0.44 0.25 lasso 8 0.26 6.4e-13 9.5 8.8 1.2e-18 0.14 1.00 0.00 FALSE
9 GTEx Esophagus Mucosa SPATA6L 0.24 0.26 lasso 2 0.27 2.0e-18 5.9 8.0 1.4e-15 0.09 1.00 0.00 FALSE
10 GTEx Muscle Skeletal CDC37L1 0.14 0.08 enet 14 0.08 1.7e-08 8.3 6.8 1.0e-11 0.11 1.00 0.00 FALSE
11 GTEx Nerve Tibial JAK2 0.17 0.08 enet 26 0.07 1.8e-05 -6.2 -8.5 1.6e-17 -0.14 0.36 0.18 TRUE
12 GTEx Skin Not Sun Exposed Suprapubic SPATA6L 0.37 0.34 enet 23 0.34 2.4e-19 9.5 10.1 3.5e-24 0.15 1.00 0.00 FALSE
13 GTEx Skin Sun Exposed Lower leg SPATA6L 0.51 0.36 lasso 5 0.42 2.1e-37 9.5 9.0 2.2e-19 0.12 1.00 0.00 FALSE
14 GTEx Thyroid SPATA6L 0.37 0.31 enet 26 0.33 5.5e-26 9.5 9.7 2.1e-22 0.15 1.00 0.00 FALSE
15 METSIM Adipose PPAPDC2 0.05 0.01 enet 21 0.01 2.9e-03 6.3 5.8 7.2e-09 0.07 0.78 0.01 FALSE
16 ROSMAP Brain Pre-frontal Cortex SPATA6L 0.08 0.00 bslmm 775 0.02 2.1e-03 6.8 6.9 5.2e-12 0.17 0.66 0.02 FALSE
17 ROSMAP Brain Pre-frontal Cortex CDC37L1 0.09 0.07 lasso 3 0.08 4.6e-11 5.7 -7.7 1.1e-14 -0.09 1.00 0.00 FALSE
18 ROSMAP Brain Pre-frontal Cortex KIAA1432 0.05 0.00 blup 502 0.02 7.5e-04 2.9 5.9 2.9e-09 0.10 0.12 0.02 TRUE
19 ROSMAP Brain Pre-frontal Cortex RCL1 0.11 0.06 bslmm 641 0.07 9.3e-10 -5.5 -12.4 1.6e-35 -0.65 0.38 0.62 FALSE
20 ROSMAP Brain Pre-frontal Cortex IL33 0.20 0.17 bslmm 440 0.22 1.8e-28 -8.1 -8.0 9.7e-16 -0.02 0.02 0.98 FALSE
21 ROSMAP Brain Pre-frontal Cortex RP11-390F4.6 0.06 0.00 blup 566 0.02 1.2e-03 -8.3 6.4 1.2e-10 0.03 0.02 0.92 FALSE
22 ROSMAP Brain Pre-frontal Cortex IGHEP2 0.08 0.07 enet 12 0.08 3.7e-10 5.9 -5.9 3.7e-09 -0.03 1.00 0.00 FALSE
23 YFS Blood PPAPDC2 0.19 0.11 bslmm 676 0.12 7.5e-38 9.5 10.5 5.5e-26 0.09 1.00 0.00 FALSE
24 YFS Blood RCL1 0.10 0.09 lasso 1 0.09 4.4e-27 -7.7 -7.7 1.5e-14 -0.34 1.00 0.00 TRUE
25 The Cancer Genome Atlas Breast Invasive Carcinoma AK3 0.05 0.00 blup 79 0.01 1.0e-03 -3.5 7.6 4.1e-14 0.20 0.01 0.07 TRUE
26 The Cancer Genome Atlas Breast Invasive Carcinoma C9orf68 0.11 0.10 lasso 4 0.11 6.1e-21 9.5 9.4 4.6e-21 0.11 0.00 1.00 FALSE
27 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C9orf68 0.09 0.04 blup 145 0.04 4.2e-05 8.3 8.1 5.1e-16 0.05 0.01 0.99 FALSE
28 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C9orf68 0.17 0.17 enet 10 0.15 7.2e-09 9.8 8.6 6.3e-18 0.11 0.00 1.00 FALSE
29 The Cancer Genome Atlas Brain Lower Grade Glioma AK3 0.05 0.01 blup 79 0.02 2.2e-03 -2.0 7.6 3.3e-14 0.25 0.03 0.13 FALSE
30 The Cancer Genome Atlas Brain Lower Grade Glioma C9orf68 0.18 0.05 enet 23 0.12 2.0e-13 3.8 6.5 7.3e-11 0.11 0.01 0.99 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma IL33 0.07 0.07 blup 59 0.07 1.9e-08 -8.1 -8.5 1.7e-17 -0.03 0.01 0.99 TRUE
32 The Cancer Genome Atlas Brain Lower Grade Glioma PPAPDC2 0.08 0.03 lasso 6 0.04 6.0e-05 9.5 9.5 2.1e-21 0.13 0.00 1.00 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma RCL1 0.04 0.02 enet 5 0.03 5.3e-04 9.3 -11.3 9.0e-30 -0.64 0.03 0.88 TRUE
34 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C9orf68 0.17 0.15 enet 12 0.15 1.2e-06 9.5 10.0 1.7e-23 0.12 0.00 1.00 FALSE
35 The Cancer Genome Atlas Prostate Adenocarcinoma C9orf68 0.17 0.09 enet 39 0.15 3.0e-15 9.5 6.3 2.6e-10 0.07 0.00 1.00 FALSE
36 The Cancer Genome Atlas Prostate Adenocarcinoma PPAPDC2 0.12 0.01 enet 14 0.04 9.4e-05 -7.8 11.4 2.9e-30 0.03 0.01 0.82 TRUE
37 The Cancer Genome Atlas Thyroid Carcinoma C9orf68 0.43 0.33 enet 28 0.34 9.3e-35 9.5 9.3 1.4e-20 0.10 0.01 0.99 FALSE
38 The Cancer Genome Atlas Thyroid Carcinoma PPAPDC2 0.10 0.10 enet 6 0.11 1.3e-10 9.5 -9.5 1.8e-21 -0.13 0.01 0.99 FALSE
39 The Cancer Genome Atlas Thyroid Carcinoma RCL1 0.06 0.03 blup 130 0.04 1.1e-04 -7.7 -10.5 6.1e-26 -0.46 0.55 0.04 TRUE