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chr9:3,855,616-7,368,850

Best TWAS P=1.57e-42 · Best GWAS P=1.61e-105 conditioned to 3.28e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	CommonMind	Brain Pre-frontal Cortex	RCL1	0.10	0.07	bslmm	632	0.05	4.2e-07	13.1	13.7	1.6e-42	0.70	0.60	0.39	TRUE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPAPDC2	0.12	0.01	enet	14	0.04	9.4e-05	-7.8	11.4	2.9e-30	0.03	0.01	0.82	TRUE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	RCL1	0.04	0.02	enet	5	0.03	5.3e-04	9.3	-11.3	9.0e-30	-0.64	0.03	0.88	TRUE
39	The Cancer Genome Atlas	Thyroid Carcinoma	RCL1	0.06	0.03	blup	130	0.04	1.1e-04	-7.7	-10.5	6.1e-26	-0.46	0.55	0.04	TRUE
11	GTEx	Nerve Tibial	JAK2	0.17	0.08	enet	26	0.07	1.8e-05	-6.2	-8.5	1.6e-17	-0.14	0.36	0.18	TRUE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL33	0.07	0.07	blup	59	0.07	1.9e-08	-8.1	-8.5	1.7e-17	-0.03	0.01	0.99	TRUE
24	YFS	Blood	RCL1	0.10	0.09	lasso	1	0.09	4.4e-27	-7.7	-7.7	1.5e-14	-0.34	1.00	0.00	TRUE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	AK3	0.05	0.00	blup	79	0.01	1.0e-03	-3.5	7.6	4.1e-14	0.20	0.01	0.07	TRUE
4	GTEx	Brain Cerebellum	SPATA6L	0.41	0.01	lasso	7	0.09	1.7e-03	7.5	7.0	2.4e-12	0.06	0.15	0.05	TRUE
18	ROSMAP	Brain Pre-frontal Cortex	KIAA1432	0.05	0.00	blup	502	0.02	7.5e-04	2.9	5.9	2.9e-09	0.10	0.12	0.02	TRUE
7	GTEx	Cells Transformed fibroblasts	AK3	0.15	0.07	lasso	6	0.04	3.9e-04	-1.9	5.3	1.2e-07	0.13	0.71	0.18	TRUE
19	ROSMAP	Brain Pre-frontal Cortex	RCL1	0.11	0.06	bslmm	641	0.07	9.3e-10	-5.5	-12.4	1.6e-35	-0.65	0.38	0.62	FALSE
23	YFS	Blood	PPAPDC2	0.19	0.11	bslmm	676	0.12	7.5e-38	9.5	10.5	5.5e-26	0.09	1.00	0.00	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	SPATA6L	0.37	0.34	enet	23	0.34	2.4e-19	9.5	10.1	3.5e-24	0.15	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C9orf68	0.17	0.15	enet	12	0.15	1.2e-06	9.5	10.0	1.7e-23	0.12	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	JAK2	0.09	0.02	lasso	5	0.03	1.0e-04	13.2	-9.9	2.5e-23	-0.53	0.73	0.06	FALSE
14	GTEx	Thyroid	SPATA6L	0.37	0.31	enet	26	0.33	5.5e-26	9.5	9.7	2.1e-22	0.15	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	PPAPDC2	0.10	0.10	enet	6	0.11	1.3e-10	9.5	-9.5	1.8e-21	-0.13	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPAPDC2	0.08	0.03	lasso	6	0.04	6.0e-05	9.5	9.5	2.1e-21	0.13	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	C9orf68	0.11	0.10	lasso	4	0.11	6.1e-21	9.5	9.4	4.6e-21	0.11	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	C9orf68	0.43	0.33	enet	28	0.34	9.3e-35	9.5	9.3	1.4e-20	0.10	0.01	0.99	FALSE
13	GTEx	Skin Sun Exposed Lower leg	SPATA6L	0.51	0.36	lasso	5	0.42	2.1e-37	9.5	9.0	2.2e-19	0.12	1.00	0.00	FALSE
8	GTEx	Colon Transverse	SPATA6L	0.44	0.25	lasso	8	0.26	6.4e-13	9.5	8.8	1.2e-18	0.14	1.00	0.00	FALSE
5	GTEx	Breast Mammary Tissue	SPATA6L	0.30	0.13	lasso	2	0.15	5.7e-08	9.5	8.8	1.4e-18	0.11	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C9orf68	0.17	0.17	enet	10	0.15	7.2e-09	9.8	8.6	6.3e-18	0.11	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	IL33	0.09	0.07	bslmm	453	0.08	1.7e-09	-8.1	-8.5	2.2e-17	-0.03	0.02	0.98	FALSE
6	GTEx	Breast Mammary Tissue (Female)	SPATA6L	0.31	0.07	lasso	4	0.07	4.4e-03	5.9	8.4	3.7e-17	0.09	0.13	0.05	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C9orf68	0.09	0.04	blup	145	0.04	4.2e-05	8.3	8.1	5.1e-16	0.05	0.01	0.99	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	IL33	0.20	0.17	bslmm	440	0.22	1.8e-28	-8.1	-8.0	9.7e-16	-0.02	0.02	0.98	FALSE
9	GTEx	Esophagus Mucosa	SPATA6L	0.24	0.26	lasso	2	0.27	2.0e-18	5.9	8.0	1.4e-15	0.09	1.00	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	CDC37L1	0.09	0.07	lasso	3	0.08	4.6e-11	5.7	-7.7	1.1e-14	-0.09	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	AK3	0.05	0.01	blup	79	0.02	2.2e-03	-2.0	7.6	3.3e-14	0.25	0.03	0.13	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	SPATA6L	0.08	0.00	bslmm	775	0.02	2.1e-03	6.8	6.9	5.2e-12	0.17	0.66	0.02	FALSE
10	GTEx	Muscle Skeletal	CDC37L1	0.14	0.08	enet	14	0.08	1.7e-08	8.3	6.8	1.0e-11	0.11	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	C9orf68	0.18	0.05	enet	23	0.12	2.0e-13	3.8	6.5	7.3e-11	0.11	0.01	0.99	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	RP11-390F4.6	0.06	0.00	blup	566	0.02	1.2e-03	-8.3	6.4	1.2e-10	0.03	0.02	0.92	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	C9orf68	0.17	0.09	enet	39	0.15	3.0e-15	9.5	6.3	2.6e-10	0.07	0.00	1.00	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	IGHEP2	0.08	0.07	enet	12	0.08	3.7e-10	5.9	-5.9	3.7e-09	-0.03	1.00	0.00	FALSE
15	METSIM	Adipose	PPAPDC2	0.05	0.01	enet	21	0.01	2.9e-03	6.3	5.8	7.2e-09	0.07	0.78	0.01	FALSE