TWAS hub - ACO1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0630	0.0340	1.9e-02	0.048	0.014	0.039	0.038	0.044	1.6e-06	7.0e-03	1.3e-05	2.0e-05	4.5e-06
2	GTEx	Artery Tibial	0.1554	0.0491	2.5e-04	0.015	NA	0.064	NA	0.056	2.1e-02	NA	9.0e-06	NA	3.6e-05
3	GTEx	Brain Cerebellar Hemisphere	0.3690	0.1360	6.4e-03	0.212	NA	0.319	NA	0.324	3.8e-06	NA	6.0e-09	NA	4.2e-09
4	GTEx	Brain Cerebellum	0.2190	0.0890	5.2e-03	0.329	NA	0.264	NA	0.306	1.7e-10	NA	2.0e-08	NA	1.0e-09
5	GTEx	Brain Cortex	0.2090	0.0850	9.6e-03	0.079	NA	0.106	NA	0.147	3.4e-03	NA	7.4e-04	NA	7.5e-05
6	GTEx	Colon Sigmoid	0.1850	0.0680	2.5e-03	0.005	NA	0.037	NA	0.020	2.0e-01	NA	1.9e-02	NA	6.3e-02
7	GTEx	Heart Left Ventricle	0.1780	0.0712	6.7e-03	0.071	NA	0.007	NA	0.066	1.2e-04	NA	1.4e-01	NA	2.2e-04
8	GTEx	Nerve Tibial	0.1278	0.0499	5.1e-03	-0.003	NA	0.014	NA	-0.004	5.5e-01	NA	3.3e-02	NA	8.0e-01
9	METSIM	Adipose	0.0527	0.0276	2.7e-02	-0.002	0.002	0.002	0.004	0.000	7.9e-01	1.5e-01	1.7e-01	6.8e-02	3.2e-01
10	YFS	Blood	0.1991	0.0318	0.0e+00	0.064	0.112	0.124	0.122	0.114	3.2e-20	1.5e-34	2.6e-38	1.1e-37	3.4e-35
11	TCGA	Prostate Adenocarcinoma	0.1691	0.0533	2.0e-06	0.017	0.066	0.038	NA	0.034	5.4e-03	2.1e-07	7.7e-05	NA	1.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Family relationship satisfaction	5.8	7.1	16.2	2.2	1.9	3.3	3.8	3.1	-1.3	1.1	4.0	1.1	-3.8	-0.7
Illness, injury, bereavement, stress in last 2 years	3.8	4.7	18.8	0.3	-0.2	-4.3	-3.4	-2.8	-1.0	-1.0	-2.4	-1.3	1.8	-0.7
Frequency of depressed mood in last 2 weeks	3.6	5.0	13.4	0.6	0.2	3.7	3.1	2.2	0.4	0.5	3.3	1.4	-3.1	-1.8
Severe depression (siblings)	3.0	3.4	7.2	2.0	2.0	2.0	2.7	2.7	-0.5	1.4	0.7	1.9	-2.0	-0.8
Sensitivity / hurt feelings	2.9	4.9	11.0	2.1	2.2	2.8	3.2	2.9	0.6	1.1	2.1	1.3	-3.3	-0.7
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.7	13.2	-1.4	-1.9	-1.8	-2.5	-1.8	-2.4	0.4	0.2	-3.6	1.6	0.9
Lung cancer (father)	2.9	3.4	7.9	2.4	2.1	1.8	2.8	2.4	1.9	0.5	1.9	0.3	-1.7	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	10.9	1.3	0.1	3.3	3.1	2.5	0.9	-1.0	0.7	1.4	-1.5	1.2
Hearing difficulty/problems with background noise	2.6	4.2	16.2	1.0	1.6	3.7	1.8	1.9	0.5	0.5	4.0	0.7	-2.0	1.0
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	12.7	-0.0	-1.0	3.6	3.0	2.0	1.0	-0.6	3.0	1.2	-2.4	-1.1
Bilateral oophorectomy (both ovaries removed)	2.3	2.6	6.6	1.2	1.7	1.2	1.8	2.0	2.6	0.8	-0.6	0.7	-2.6	-1.0
Average weekly fortified wine intake	2.2	2.5	6.5	0.2	0.5	2.4	2.5	2.5	0.5	1.1	1.7	0.4	-0.7	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	6.9	-0.3	1.0	1.8	1.5	2.3	-0.1	2.6	2.6	0.6	-2.0	-0.8
Mood swings	2.2	3.9	14.7	1.6	0.9	2.7	2.3	2.1	1.5	-0.6	0.9	1.4	-3.8	-1.4
Financial situation satisfaction	2.2	2.8	8.6	0.1	0.7	2.9	2.0	1.7	-0.8	-0.5	1.9	0.5	-2.8	-1.5
Depression (Nagel 2018)	2.1	3.2	9.5	-0.2	0.2	3.1	2.5	2.1	0.2	0.2	1.9	1.0	-3.0	-1.2
Blood Red Count	2.1	20.5	78.5	-8.9	-8.3	1.6	-4.2	-6.0	-1.1	-2.1	1.7	-2.5	1.6	-2.2
Medication: Ibuprofen	2.1	2.5	9.1	-1.4	-1.3	-1.3	-2.3	-1.3	-1.8	0.7	0.4	-3.0	1.2	0.9
Medication: Aspirin	2.0	2.6	11.8	1.2	0.9	1.4	1.5	0.8	-0.8	-1.9	2.2	3.4	-1.1	0.2
Hearing difficulty/problems: Yes	1.9	2.9	7.6	-0.2	0.8	2.8	1.2	2.1	2.0	1.5	2.3	0.8	-1.2	2.0
Pack years of smoking	1.9	2.8	7.8	-0.1	0.0	2.5	2.0	1.8	1.6	-0.2	1.9	2.8	-1.2	1.5
Alcohol intake versus 10 years previously	1.8	2.7	5.3	2.3	2.0	2.2	1.4	1.2	1.3	-0.5	0.8	0.9	-2.3	-2.0
Length of working week for main job	1.8	2.0	7.1	-0.5	0.4	1.9	1.5	2.7	1.2	1.2	2.0	-0.5	-1.3	0.7
Coronary Artery Disease (CAD)	1.7	2.0	7.7	0.5	-1.4	-1.5	-1.1	-1.9	-2.8	-1.8	-0.6	-1.2	0.5	0.0
Qualifications: CSEs or equivalent	1.7	2.3	5.3	1.5	1.9	0.8	1.8	1.4	1.2	1.9	0.2	-0.4	-1.6	-2.3
Prospective memory result	1.7	2.1	9.7	0.8	1.5	0.9	0.5	1.4	1.0	3.1	0.9	0.8	-1.5	-1.5
Osteoarthritis (self-reported)	1.7	2.1	8.5	-0.2	0.4	2.9	1.4	1.9	0.6	1.0	2.2	0.4	-1.4	1.0
Pack years adult smoking proportion	1.6	2.5	6.5	-0.2	-0.1	2.5	2.0	1.7	1.5	-0.2	1.8	2.5	-0.9	1.3
Heart attack	1.6	2.0	4.7	1.1	0.6	0.9	1.9	1.7	-0.1	-1.8	1.0	1.9	-0.7	2.2
Worry too long after embarrassment	1.6	2.7	8.3	0.6	0.9	2.9	2.5	1.3	0.9	-0.4	1.6	-0.2	-2.5	-1.5
Chest pain or discomfort	1.6	2.3	7.1	-2.0	-2.1	1.8	1.5	0.1	-1.4	-0.6	2.7	0.3	-1.4	0.4
Neuroticism (Nagel 2018)	1.5	3.5	9.6	1.9	1.8	2.4	3.1	2.5	1.8	-0.3	0.8	0.5	-2.5	-0.6
Neuroticism (2016)	1.5	2.2	7.4	1.3	0.7	1.6	2.6	0.9	0.2	-0.3	0.3	1.0	-2.7	-1.8
Triglycerides	1.5	2.4	6.6	0.7	-0.6	-2.6	-1.1	-2.3	-1.9	-0.4	-1.8	-1.7	0.7	-1.4
Ever had hysterectomy (womb removed)	1.5	1.7	5.0	1.1	2.2	0.1	0.5	1.8	1.4	1.9	-1.0	-0.4	-1.4	-0.2
Medication: Co-codamol	1.5	1.8	6.8	0.6	1.2	1.3	0.8	1.0	1.5	0.3	1.5	2.6	-1.0	-1.4
Birth weight	1.5	3.1	6.2	-1.0	-1.1	-2.4	-2.4	-2.5	-1.6	-0.1	-1.1	-2.3	2.5	0.3
Eye problems/disorders: None of the above	1.5	1.8	5.9	0.7	0.8	1.6	2.0	2.4	-0.7	1.4	0.8	-0.8	-1.3	0.6
Medication: Aspirin	1.5	2.0	11.6	0.8	1.0	1.1	1.1	0.8	-0.4	-1.0	1.9	3.4	-1.1	-0.1
Mother’s age at death	1.5	1.9	6.5	1.8	2.5	0.2	1.2	1.6	1.3	0.4	1.1	1.6	-0.6	1.1
Depressed Affect (Nagel 2018)	1.4	2.9	8.5	0.7	0.8	2.5	2.6	1.7	1.0	-0.4	1.4	1.5	-2.9	-0.8
Type 2 Diabetes (T2D) (2012)	1.4	1.6	5.3	1.4	0.3	0.1	0.8	-0.5	-2.0	-1.9	-0.6	-0.8	-0.9	-2.3
Medication: Atenolol	1.4	1.8	7.0	1.2	1.5	0.7	0.5	0.3	-2.6	1.4	2.0	1.1	-0.5	-0.9
Neuroticism score	1.4	2.9	10.2	1.0	0.3	2.6	2.7	2.1	0.9	-0.3	1.1	-0.6	-3.2	-0.4
Peak expiratory flow (PEF)	1.4	3.2	6.1	-0.7	-0.2	2.2	1.5	2.4	2.5	2.4	1.4	1.6	1.9	1.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	6.7	1.6	0.0	1.8	2.6	2.0	1.1	-0.3	-1.1	-0.1	-0.3	-0.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.8	1.6	1.9	1.6	1.4	1.6	-0.3	0.9	0.3	0.8	-2.2	-0.1
Leg pain on walking	1.4	1.8	4.2	0.2	-2.0	1.7	2.0	1.2	0.8	-1.1	1.8	1.2	-1.0	-0.3
Handedness (chirality/laterality): Left-handed	1.4	1.6	5.6	-1.3	-1.1	-1.1	-1.7	-2.4	-0.6	0.5	-0.2	-1.8	1.1	-0.4
Osteoporosis (self-reported)	1.4	1.7	6.5	-1.3	0.5	1.4	0.7	1.5	0.9	2.5	-0.3	-1.1	-1.7	-0.6
Ever had prostate specific antigen (PSA) test	1.4	1.7	8.1	-0.4	0.5	-1.0	-1.2	-0.2	0.4	0.3	0.8	1.6	2.0	2.9
Maternal smoking around birth	1.3	1.8	4.8	2.0	0.6	0.6	0.9	0.6	-1.7	-1.1	2.2	1.6	0.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	6.2	0.0	-0.1	2.1	1.9	1.2	0.2	-0.2	0.9	0.9	-2.5	-1.5
Serious illness, injury or assault to yourself	1.3	1.6	4.3	0.0	0.4	2.1	2.0	1.5	-0.0	1.3	1.5	0.9	-1.3	-0.4
Birth weight of first child	1.3	2.4	10.9	0.7	1.0	-0.2	0.1	1.0	2.9	-0.3	-0.8	1.8	0.4	3.3
Medication: Amlodipine	1.3	1.8	4.5	0.6	1.8	0.8	1.3	1.2	-0.0	1.2	1.9	0.7	-2.1	-1.6
Commuting to job workplace: Cycle	1.3	1.6	6.5	0.1	0.3	1.3	1.4	0.7	-0.2	-0.8	2.0	2.6	-1.3	0.9
Vascular/heart problems diagnosed by doctor	1.3	3.4	18.1	-0.8	-1.4	-1.0	-1.6	-1.4	0.8	-1.1	-1.6	-1.6	4.2	2.1
Heart attack/myocardial infarction (self-reported)	1.3	1.7	5.2	0.8	0.1	0.7	1.5	1.3	-0.5	-2.0	0.8	1.7	-0.4	2.3
Lupus	1.2	1.8	5.5	1.8	0.9	-2.3	-0.6	0.9	-0.0	-1.0	-2.0	-1.9	-0.2	0.0
Angina	1.2	1.6	5.7	0.7	0.6	1.3	1.2	1.7	1.0	-0.5	1.8	2.4	-0.3	0.7
Age when periods started (menarche)	1.2	2.8	12.0	0.3	1.1	1.5	0.8	1.4	1.8	0.5	3.5	2.9	-1.1	0.6
Supplements: Glucosamine	1.2	1.6	3.9	-1.1	-0.9	-1.4	-0.9	-1.4	0.7	-1.9	-1.0	0.1	2.0	1.4
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	5.9	0.2	-1.1	2.4	1.7	1.4	1.1	-1.0	1.6	0.4	-0.8	1.6
Happiness	1.2	1.5	3.2	-1.7	-1.4	1.4	0.4	-0.1	-1.6	-0.1	1.8	-0.1	-1.8	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	5.0	0.0	-0.2	2.1	1.8	1.8	-0.9	-0.0	2.2	0.2	-1.8	0.9
Angina (self-reported)	1.2	1.6	5.3	0.5	0.6	1.4	1.2	1.7	1.1	-0.6	2.0	2.3	-0.2	0.5
Had major operations	1.2	1.4	7.2	-1.7	-0.4	-1.1	-0.9	-0.4	-0.3	-0.4	-0.8	-1.6	0.1	2.7
Guilty feelings	1.2	1.9	4.5	1.2	1.5	2.1	1.3	1.3	1.4	-0.8	1.3	0.6	-2.1	-0.3
Basal cell carcinoma (self-reported)	1.2	1.4	3.2	-0.2	-0.1	-1.8	-1.3	-1.1	1.0	-1.1	-1.8	-1.1	1.4	0.8
Fed-up feelings	1.1	2.1	8.4	1.0	0.6	1.8	2.3	1.6	-0.1	-0.2	0.6	-0.0	-2.9	-1.2
Worrier / anxious feelings	1.1	2.0	3.9	1.9	1.1	1.7	1.9	1.5	0.9	0.2	2.0	-0.1	-1.6	-1.1
Medication: Cholesterol lowering	1.1	1.7	5.5	0.6	1.2	1.0	1.4	1.3	0.1	-0.3	2.3	2.0	-1.5	-0.3
Illnesses of mother	1.1	1.4	5.5	-0.6	-0.2	-0.5	-0.2	-0.3	-2.4	-1.8	-0.4	-1.4	1.2	1.6
Pulse wave reflection index	1.1	1.4	4.4	0.6	0.9	-0.5	-0.3	0.7	-1.4	2.1	0.0	-0.7	1.6	2.1
Loneliness, isolation	1.1	1.5	3.7	1.6	0.3	1.8	1.7	1.1	-0.3	-0.9	1.9	0.1	-1.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	7.5	-0.2	0.5	0.7	-0.5	0.7	2.7	2.6	-0.4	1.5	2.2	1.4
Fractured/broken bones in last 5 years	1.1	1.4	5.7	-0.2	0.3	1.7	1.1	1.4	-1.2	-0.5	2.4	-0.2	-1.3	-0.2
Supplements: Calcium	1.1	1.2	4.2	0.3	1.1	0.3	1.3	1.1	0.3	2.1	0.3	-0.1	-1.6	-1.3
Alcohol drinker status: Previous	1.1	1.3	7.4	0.3	-0.2	-0.6	-0.7	-0.7	0.4	-1.2	-0.9	0.3	1.6	2.7
Neuroticism	1.0	2.4	8.5	0.4	0.4	2.4	2.2	2.1	1.0	0.0	1.0	-0.8	-2.9	-0.4
High blood pressure	1.0	2.9	15.3	0.6	1.1	1.0	1.3	0.9	-0.5	1.3	1.5	0.8	-3.9	-2.5
Financial difficulties in last 2 years	1.0	1.3	5.4	-0.4	-0.9	2.3	1.7	1.6	0.8	0.1	0.4	-1.2	0.2	-0.3
Breastfed as a baby	1.0	1.3	3.1	-1.5	-0.0	-1.0	-1.6	-1.8	-0.4	1.1	-0.7	-1.1	0.1	-1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.6	-0.8	-0.5	-0.6	-1.0	-1.8	-1.0	-0.3	-1.1	-1.9	-0.2	-1.7
Chronic bronchitis/emphysema (mother)	1.0	1.2	4.0	0.2	-1.1	2.0	1.6	1.0	1.3	0.6	1.2	-0.1	-0.5	-0.5
Number of children fathered	1.0	1.1	4.5	-1.4	-2.1	0.7	-0.1	-0.1	1.5	-0.7	-1.0	-0.5	-0.2	-1.0
Suffer from ‘nerves’	1.0	1.6	12.0	0.2	-0.9	-0.4	-0.3	0.4	0.9	-1.2	-0.6	-0.7	1.2	3.5
Hypertension (Self-reported)	1.0	2.8	14.0	0.6	1.4	0.7	0.9	0.7	-0.4	1.3	1.6	0.7	-3.7	-2.9
Average weekly red wine intake	1.0	1.5	7.8	-0.6	-1.7	-1.1	-1.3	-0.9	0.2	-1.1	0.3	-0.1	0.7	2.8
Tinnitus: Yes, now most or all of the time	1.0	1.2	4.7	-0.8	-1.1	-0.3	-0.9	-1.3	0.4	-2.2	0.1	0.8	1.1	1.3
Commuting to job workplace: Public transport	1.0	1.2	5.4	0.4	0.2	0.9	0.8	1.1	-0.4	0.2	0.2	-1.6	-1.5	-2.3
Medication: Lisinopril	1.0	1.3	4.0	-0.1	0.1	0.3	-0.0	-0.2	0.1	1.1	2.0	-1.4	-1.6	-1.9
Ever depressed for a whole week	1.0	1.2	3.0	1.2	0.7	1.5	1.3	1.2	1.5	-0.5	-0.8	1.7	-0.4	0.6
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	4.7	-0.1	-0.3	1.6	2.2	1.5	0.6	1.1	0.8	1.2	-0.6	0.5
Worry (Nagel 2018)	0.9	1.9	5.0	1.7	1.1	1.5	2.2	2.2	1.1	-0.2	0.7	-0.7	-0.4	1.7
Prostate Cancer	0.9	1.3	7.9	-0.5	-0.4	0.5	-0.0	-1.2	0.6	-0.2	1.5	0.2	-1.1	-2.8
Bipolar Disorder (2011)	0.9	0.9	4.4	0.2	-1.0	-0.1	0.7	1.4	-0.5	-0.1	-0.6	-0.5	0.7	2.1
HbA1C	0.9	1.0	2.8	0.8	1.4	-1.6	-0.3	-0.3	-1.1	0.2	-0.6	1.7	-0.5	0.8
Schizophrenia (2014)	0.9	2.0	13.0	0.6	0.1	0.9	0.5	1.4	-1.2	-0.7	3.6	1.5	-0.8	0.9
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.4	-1.0	-0.4	0.4	-0.4	-1.2	-1.4	0.4	1.2	-1.2	-1.8	-1.3
Supplements: Zinc	0.9	1.0	5.4	0.0	-1.0	1.2	1.2	-0.4	-0.6	-2.3	1.1	-0.1	-0.2	0.0
Chronic bronchitis/emphysema (father)	0.9	1.1	7.1	-0.0	-1.9	-0.3	0.1	0.3	-0.5	-0.4	0.2	-2.7	0.4	0.3
Nervous feelings	0.9	1.7	3.9	1.8	1.6	1.4	1.6	2.0	1.4	-0.3	0.1	0.5	-0.7	1.4
Depression (self-reported)	0.9	1.1	2.4	1.4	1.0	1.0	1.4	1.5	-0.0	0.3	-0.3	1.6	-0.2	1.2
Gout (self-reported)	0.9	1.3	3.1	-0.8	-0.4	-1.3	-1.7	-1.4	-0.2	-0.1	-1.7	-1.4	0.1	-1.2
Medication: Omeprazole	0.9	1.1	3.2	-0.1	-1.4	1.4	1.8	1.1	1.0	0.7	0.8	1.1	0.2	0.3
Number of full sisters	0.9	1.1	3.2	-0.3	-0.3	1.0	0.8	1.1	0.3	1.0	-0.2	-1.8	-1.3	-1.7
Breast cancer (self-reported)	0.9	1.1	2.6	1.3	1.0	0.2	0.3	1.0	-0.4	-1.2	0.9	1.6	-0.5	1.5
Illnesses of father: None of the above (group 1)	0.9	1.1	2.6	1.4	1.6	-1.4	-0.5	-1.1	-0.6	-1.0	-1.4	-0.7	0.2	0.1
Medication: Blood pressure	0.9	1.8	5.6	1.0	1.2	1.7	0.9	1.0	-0.6	0.3	1.9	1.4	-2.4	-0.8
Unable to work because of sickness or disability	0.9	1.1	2.8	1.2	0.9	1.1	1.5	1.2	0.9	0.6	0.8	0.6	-1.7	-0.7
Myopia	0.9	1.3	4.9	-0.9	-0.5	-1.5	-1.4	-1.1	0.2	-0.3	-0.9	-1.1	2.2	0.6
Bipolar Disorder or Schizophrenia	0.8	2.0	8.8	1.0	-0.2	1.7	1.5	1.7	-0.5	-0.7	3.0	1.2	-1.0	1.3
Cardiovascular Disease	0.8	2.7	14.2	-0.3	0.5	0.2	0.5	0.2	-1.1	2.1	1.3	-0.5	-2.6	-3.8
Hypothyroidism (self reported)	0.8	1.8	4.2	-0.5	-0.3	1.5	1.9	2.1	1.6	0.1	0.6	1.9	-1.3	0.7
Hand grip strength (left)	0.8	2.0	6.8	0.1	-1.1	-1.4	-1.1	-0.8	0.3	-1.1	-1.7	-0.5	2.6	2.4
Average weekly spirits intake	0.8	1.0	3.3	0.2	1.8	0.0	1.1	1.1	-1.8	-0.6	-0.9	0.1	-0.2	1.0
Relative age voice broke	0.8	1.1	4.9	0.4	0.8	-0.7	-0.9	0.7	1.6	0.8	-0.8	-0.2	1.2	2.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.2	-1.2	-1.7	-1.3	-1.5	-1.6	1.2	0.5	-0.9	-2.0	0.9	0.2
Alcohol usually taken with meals	0.8	1.3	5.3	-0.3	0.5	-0.2	0.1	0.9	2.3	1.0	1.0	0.3	0.4	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	6.4	-0.3	0.2	1.6	1.1	1.7	2.5	1.7	0.8	1.5	-1.0	-0.9
Number of live births	0.8	1.2	3.7	-1.4	-1.1	-0.9	-1.2	-0.7	-0.3	0.2	-0.6	-1.9	1.3	0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.2	-1.8	-1.4	-0.9	-1.8	-1.2	-0.6	0.3	0.9	-1.4	2.1	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	6.3	-1.6	-1.0	1.4	0.6	1.5	2.4	2.5	-0.5	-0.1	2.1	1.5
Exposure to tobacco smoke at home	0.8	0.8	2.5	0.3	1.0	1.6	0.4	1.2	-0.1	-0.0	1.4	-0.1	1.1	1.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.5	-0.5	-1.6	0.1	-0.7	-0.3	0.2	-0.4	-1.7	-1.9	1.9	1.5
Emphysema/chronic bronchitis	0.8	0.9	2.3	-0.6	-1.1	0.9	0.6	0.4	1.5	-0.9	0.4	1.3	-1.1	0.7
Overall health rating	0.8	1.7	7.7	-0.7	-0.8	2.2	1.1	1.1	-0.2	-0.3	1.3	-0.3	-2.8	-0.0
Friendships satisfaction	0.8	1.0	8.4	0.8	0.6	-0.0	-0.3	-0.2	-0.8	-0.1	2.9	-0.7	-0.7	-0.6
Qualifications: nursing, teaching	0.8	1.2	3.2	-1.5	-1.0	-0.2	-1.8	-1.6	-0.3	-0.8	-1.1	-0.8	0.6	1.1
Number of self-reported non-cancer illnesses	0.8	1.3	6.1	-0.1	0.5	0.7	1.0	0.9	0.4	2.5	1.0	0.6	-2.1	0.3
Miserableness	0.8	1.4	3.3	-1.1	-1.4	1.6	1.3	0.1	0.3	-0.4	1.5	1.4	-1.8	0.5
High cholesterol (Self-reported)	0.8	1.4	5.6	0.0	1.2	0.8	1.0	0.4	0.5	0.6	2.4	1.1	-1.5	-1.6
Age started oral contraceptive pill	0.8	1.0	2.3	1.1	1.5	-0.9	-1.5	-1.1	0.0	0.2	0.8	1.4	0.1	0.6
Schizophrenia (2018)	0.7	1.6	7.9	0.7	0.5	1.4	0.7	1.4	-0.0	-0.4	2.8	1.5	-1.1	0.5
Schizophrenia vs Biploar Disorder	0.7	0.9	5.6	-0.6	-0.1	0.9	-0.2	0.4	1.0	-0.2	-0.2	-0.0	-1.3	-2.4
Alzheimer’s Disease (in mother)	0.7	0.8	3.5	-1.9	-0.4	-0.1	-0.7	-0.1	1.8	-0.4	0.1	0.3	-1.1	-0.0
Rheumatoid Arthritis	0.7	1.0	1.9	-1.2	-1.1	1.2	0.8	-0.3	-0.8	1.2	0.4	-0.0	-1.4	-1.4
Smoking Status	0.7	1.7	12.4	-0.8	-0.6	0.3	0.2	-0.1	-3.5	-0.9	1.3	0.6	-0.7	-1.2
Respiratory disease	0.7	1.5	6.3	-2.0	-2.5	1.3	0.6	-0.2	1.1	-0.4	0.9	-0.5	-1.3	-0.3
Medication for hormone replacement therapy	0.7	0.8	2.6	0.9	1.0	1.0	0.8	0.9	1.6	-1.1	-0.4	-0.0	-0.3	0.7
Had menopause	0.7	0.9	3.2	0.0	-0.2	-1.8	-1.4	-1.6	-0.2	-1.0	0.7	0.6	0.6	0.2
Qualifications: None of the above	0.7	1.6	7.0	1.0	-0.2	1.0	1.9	0.0	-1.2	-0.5	-0.8	0.5	-2.6	-1.5
Mouth/teeth dental problems	0.7	1.0	3.0	0.2	0.2	-1.6	-1.6	-1.1	0.1	-1.1	0.6	-0.2	1.7	-0.4
Falls in the last year	0.7	0.9	3.7	1.9	1.4	0.5	0.6	1.0	0.9	0.7	0.9	-0.5	-0.4	0.6
Loud music exposure frequency	0.7	0.7	1.6	-1.0	-1.2	1.1	-0.3	-0.6	-0.7	-1.3	0.2	0.3	0.9	1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.3	-0.3	-0.5	-1.6	-1.8	-1.1	-0.4	-0.4	-0.1	-1.3	1.8	0.2
High blood pressure (siblings)	0.7	1.0	2.6	0.7	1.6	0.9	1.1	1.3	0.2	1.6	-0.1	0.3	-0.7	-0.8
Health satisfaction	0.7	1.0	4.1	-0.1	-2.0	-0.2	0.4	-0.4	-0.6	-1.6	0.5	-0.5	-0.3	1.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	3.8	1.0	1.3	-0.4	0.2	-0.3	-2.0	1.0	0.3	0.1	0.4	-1.0
Medication: Allopurinol	0.7	1.0	3.4	-1.3	0.2	-0.5	-1.2	-0.8	0.0	1.9	-0.2	-0.6	-0.8	-1.5
Illnesses of father: Heart disease	0.7	1.0	7.7	-0.0	-0.6	1.1	0.5	0.6	-0.2	-0.6	0.7	2.8	0.1	0.2
Diabetes diagnosed by doctor	0.7	1.2	4.8	0.6	2.2	0.5	1.2	1.2	-0.5	-0.0	0.4	0.9	-1.8	-0.8
Commuting to job workplace: Walk	0.7	0.8	2.5	1.6	1.4	0.8	0.8	0.0	-0.5	-0.2	0.9	0.2	-1.0	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.9	-1.9	-2.0	0.1	-0.0	-0.6	0.7	1.2	-1.3	-0.8	0.2	-0.4
Ever taken oral contraceptive pill	0.7	0.8	3.2	1.0	1.2	-0.3	-0.1	1.0	0.3	1.8	-0.7	-0.3	0.1	1.1
Ever smoked	0.7	1.2	5.6	-1.4	-1.3	-0.3	-0.7	-0.7	-2.4	-0.8	-1.1	-1.1	-0.1	-0.4
Number of operations (self-reported)	0.7	1.0	3.2	-0.7	0.2	0.5	1.0	1.5	0.6	0.4	0.6	-0.5	-1.8	1.7
Diastolic blood pressure, automated reading	0.7	2.3	5.9	0.1	-0.5	2.3	1.9	1.4	1.0	1.5	1.7	0.7	-2.4	-1.4
Bipolar Disorder (2018)	0.6	0.9	2.2	0.8	-0.9	0.9	1.4	0.9	-0.8	-0.6	1.4	0.1	-0.2	1.5
Major Depression (MDD)	0.6	0.7	1.6	0.3	-0.4	0.5	1.3	0.6	-1.0	-0.3	1.1	-0.1	-1.1	-1.3
Breast Cancer	0.6	1.5	5.5	-1.0	0.2	-2.3	-0.6	-0.1	-0.6	1.4	-2.3	-1.5	0.3	-0.3
Fasting Glucose	0.6	0.7	2.8	0.7	0.8	0.4	0.7	0.2	-1.7	1.4	0.4	0.3	-1.1	0.4
Ulcerative Colitis	0.6	0.9	2.3	1.5	1.4	0.3	0.4	0.8	1.5	0.8	1.4	0.5	-0.5	-0.2
Medication: Metformin	0.6	0.9	4.9	-0.0	2.2	-1.2	-0.7	-0.6	-0.0	0.2	-0.7	0.9	-0.4	-1.0
Diabetes (mother)	0.6	0.8	2.8	0.6	1.2	-1.2	-0.1	-0.3	0.6	0.1	-0.9	1.7	-0.0	-1.2
Hand grip strength (right)	0.6	1.6	5.4	0.1	-1.4	-0.8	-0.5	-0.0	1.1	-1.1	-1.6	-0.7	2.3	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	6.4	-1.0	-0.8	0.7	-0.2	0.3	2.5	1.8	0.3	0.8	0.1	-1.1
Stomach or abdominal pain in last month	0.6	0.8	4.1	0.0	0.7	-0.8	-0.6	-0.5	-0.4	2.0	-0.1	-0.4	-1.1	-1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.6	-0.1	-0.9	-1.2	-0.7	-1.6	0.7	-0.3	-1.0	-0.2	0.7	-0.7
Number of incorrect matches in round	0.6	1.1	3.8	2.0	1.2	-0.2	0.1	-0.2	1.4	-0.8	-0.6	1.7	-0.6	0.2
Past tobacco smoking	0.6	1.1	8.2	0.8	-0.2	0.6	0.7	0.6	2.9	0.5	0.7	0.4	0.0	0.9
Pain all over the body in last month	0.6	0.7	1.7	-0.3	0.5	0.9	0.8	1.2	1.1	1.3	0.1	0.4	-0.9	-0.7
Diabetes (self-reported)	0.6	1.0	2.3	0.4	1.0	0.8	1.3	0.8	-0.9	-0.9	0.0	0.9	-1.4	-1.5
Fluid intelligence score	0.6	1.3	6.3	-0.3	-0.9	-0.7	-0.8	-0.8	-1.4	-1.2	0.7	0.3	2.5	1.4
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	4.2	-1.3	-1.2	1.9	1.0	1.8	2.1	1.2	-0.2	0.6	1.9	1.7
Pulse rate	0.6	1.0	3.8	0.1	-0.3	1.4	1.4	0.4	0.7	-1.6	0.6	0.2	-1.9	-0.4
Noisy workplace	0.6	0.8	2.1	1.1	1.2	0.3	0.4	0.9	-0.7	0.3	1.4	1.2	-0.8	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.5	-1.4	-1.9	1.3	0.6	-0.2	0.2	-0.3	-0.2	-0.0	0.2	-0.2
Medication: Lansoprazole	0.6	0.7	1.7	0.0	0.6	1.3	0.5	0.6	0.4	0.1	1.0	1.3	-1.2	0.6
Pulse wave Arterial Stiffness index	0.6	0.7	3.5	0.4	-0.6	-0.2	0.1	0.4	-1.9	-1.0	-0.0	-0.5	-0.5	1.4
Tense / ‘highly strung’	0.6	1.0	2.8	1.4	0.6	0.7	1.1	1.5	1.7	0.5	-0.3	0.6	-0.4	1.1
Pulse wave peak to peak time	0.6	0.7	3.7	-0.2	0.7	0.3	0.1	-0.2	1.9	0.8	0.1	0.4	0.4	-1.4
Medication for pain relief, constipation, heartburn	0.6	1.0	4.4	0.6	0.5	-0.5	-0.0	-0.4	-0.0	0.5	-1.8	-1.2	0.1	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.7	-0.7	-1.3	1.3	0.9	0.4	-0.2	-0.9	1.3	0.7	-0.7	0.5
Smoking status: Previous	0.6	0.8	3.3	-1.5	-0.1	-0.6	-0.7	-0.7	-1.8	-0.2	-0.8	0.7	0.1	-1.2
Long-standing illness, disability or infirmity	0.6	0.9	3.7	-1.9	-0.5	1.3	0.1	-0.1	0.8	0.4	1.3	0.2	-1.2	0.2
Ever had bowel cancer screening	0.6	0.7	3.4	0.7	1.3	-0.6	-0.3	0.6	-0.6	1.9	0.4	0.4	-0.0	0.8
Wears glasses or contact lenses	0.6	0.7	3.4	-0.1	-0.6	1.3	0.2	0.2	-0.9	-0.7	0.6	1.9	-0.5	0.3
Eye problems/disorders: Glaucoma	0.6	0.7	3.3	-0.2	-0.4	-0.1	-1.0	-1.8	0.8	-1.6	-0.0	0.4	0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.5	1.6	0.0	1.3	0.9	0.3	0.6	-0.8	0.5	0.1	0.5	0.9
Medication: Bendroflumethiazide	0.6	0.8	3.6	0.0	0.3	0.3	0.2	0.3	-0.1	0.2	1.6	1.5	-1.9	-0.5
Medication: Atorvastatin	0.6	0.8	2.6	0.0	-0.1	0.3	1.5	0.5	0.1	-1.1	0.6	1.6	-1.0	-0.9
Illnesses of father: High blood pressure	0.6	0.8	3.2	-1.8	-1.5	1.5	-0.5	-0.1	0.5	-0.6	0.3	0.0	-0.5	-0.3
Alcohol drinker status: Never	0.6	0.7	1.4	-1.0	-1.1	-1.2	-0.5	-0.3	1.1	1.2	-0.9	0.6	-0.4	0.1
Average weekly beer plus cider intake	0.6	0.9	4.3	0.6	-0.4	0.6	1.0	0.5	0.2	-1.2	-0.6	0.8	-2.1	-0.9
Irritability	0.6	1.1	4.3	0.1	0.5	0.4	0.8	0.5	0.7	1.0	-1.1	0.6	-1.7	-2.1
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.8	0.5	1.0	-0.6	-0.2	0.2	2.2	-0.6	-0.2	1.5	2.1	1.5
Ulcerative Colitis (UC)	0.5	0.9	2.8	0.9	0.9	0.7	0.6	0.9	0.7	1.2	1.3	-0.3	-1.7	-0.7
Ovarian Cancer	0.5	0.7	1.3	0.4	0.7	1.1	0.9	0.9	-0.8	-0.0	0.8	-0.7	-0.9	-1.1
HDL Cholesterol	0.5	0.9	3.4	-0.8	-0.1	1.3	0.1	0.6	0.6	0.2	1.8	0.9	0.7	1.4
LDL Cholesterol	0.5	0.7	2.8	-0.5	-0.5	-0.9	-0.6	-1.7	-0.8	-0.4	1.2	1.1	0.1	-0.1
Blood White Count	0.5	3.4	10.0	-1.8	-2.3	2.8	1.1	-0.7	-3.2	-1.9	2.0	1.1	-0.4	0.9
Type 2 Diabetes (T2D) (2018)	0.5	1.0	4.5	0.4	2.1	0.5	1.1	0.9	-0.9	-0.4	-0.6	0.5	-1.2	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.7	3.8	0.3	0.9	0.6	0.3	0.4	2.0	-0.0	0.4	0.8	-0.6	0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.8	-0.7	-0.9	-0.1	-0.1	-1.3	-0.4	-0.4	-1.0	-0.4	-0.7	-1.2
Multivitamins +/- minerals	0.5	0.7	1.9	1.0	0.4	1.4	1.1	0.6	0.1	0.4	1.2	-0.3	-0.6	-0.9
Had other major operations	0.5	0.6	1.9	-0.3	0.6	0.7	-0.2	0.0	1.2	0.9	0.6	0.3	-1.4	-0.9
Allergy	0.5	1.1	3.8	1.1	1.9	0.6	0.8	1.3	-0.3	0.1	0.3	1.9	-0.1	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.8	-0.6	-1.4	0.1	0.6	-0.1	0.7	0.6	0.4	-1.7	0.2	1.1
Medication: Ramipril	0.5	0.7	1.7	1.2	1.1	-0.4	0.6	1.3	0.3	-0.6	0.3	0.9	-1.1	-0.1
Father’s age at death	0.5	0.7	2.3	-0.3	0.1	-0.7	-1.3	-1.0	-0.1	0.8	0.5	-1.5	0.6	0.5
Glaucoma (self-reported)	0.5	0.6	3.1	-0.9	0.0	0.2	-0.8	-1.8	-0.0	-1.0	0.1	0.9	-0.2	-0.7
Forced vital capacity (FVC), Best measure	0.5	2.0	5.2	-1.3	-1.3	0.9	0.3	1.3	2.0	1.9	-0.7	-0.6	2.3	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.0	0.6	1.1	0.9	0.4	0.9	0.8	0.6	-0.5	1.4	0.1	-0.2
Qualifications: College or University degree	0.5	1.5	4.0	-1.9	-0.9	-0.1	-2.0	-1.1	1.1	1.0	0.9	1.2	1.2	0.9
Medication: Blood pressure	0.5	0.9	3.9	0.2	1.0	-0.1	0.7	0.5	-0.7	0.1	1.2	1.0	-2.0	-1.4
Alcohol intake frequency.	0.5	1.0	2.8	1.3	1.1	1.1	1.7	1.2	1.1	0.6	-0.2	0.5	-1.2	-0.1
Age at last live birth	0.5	0.8	2.7	0.6	0.4	0.1	-0.4	1.0	1.2	0.2	-0.7	0.1	1.7	1.4
Supplements: Vitamin C	0.5	0.6	3.1	-1.0	-0.2	0.9	-0.1	-0.1	-0.3	0.9	1.8	0.4	-0.5	0.2
Knee pain experienced in last month	0.5	0.8	3.3	0.3	-0.5	1.8	1.4	1.2	0.6	0.4	-0.1	-0.1	0.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.4	-1.8	-0.5	0.9	0.2	1.4	1.4	1.3	0.5	-0.9	0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.2	1.5	0.8	-0.1	-0.2	0.4	0.4	0.8	0.5	0.1	0.9	0.9
Eye problems/disorders: Cataract	0.5	0.5	2.0	0.3	0.2	-0.2	-0.3	-0.4	1.4	-1.4	0.1	1.0	0.5	0.6
Medication for cholesterol	0.5	0.8	3.1	-0.7	-1.4	-0.6	-0.2	-0.5	0.2	-0.3	-1.8	-0.4	1.3	0.7
Medication: Gliclazide	0.5	0.6	2.3	1.5	1.2	-0.3	0.9	0.6	0.4	0.2	0.6	0.1	-0.7	-0.7
Smoking status: Current	0.5	0.8	3.9	0.4	-0.9	0.1	0.1	-0.3	-2.0	-1.3	1.1	-0.3	-0.5	0.3
Risk taking	0.5	0.8	2.6	-1.3	-0.6	0.8	0.7	0.6	0.2	1.6	0.1	1.3	-0.6	0.2
Pain experienced in last month	0.5	0.8	2.8	-0.1	1.7	-0.5	-0.4	-0.6	-0.9	-0.9	0.2	1.1	-0.2	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	3.0	0.0	1.0	-0.4	-0.3	0.2	-1.7	-0.5	-0.7	-0.4	0.0	1.2
Alzheimer’s Disease (in father)	0.4	0.5	1.6	-0.9	-0.1	0.1	-0.3	1.3	-0.3	-0.1	-0.1	0.8	0.6	1.2
Alzheimer’s Disease (including proxy)	0.4	0.6	3.0	-1.7	-0.5	0.3	-0.4	0.6	1.1	-0.3	0.4	1.0	-0.1	0.1
Age at First Birth	0.4	0.6	4.5	-0.7	0.4	0.7	-0.3	0.2	-0.4	-0.1	0.1	0.6	0.7	2.1
Primary Biliary Cirrhosis	0.4	0.6	2.3	-1.3	0.1	-1.2	-1.5	-0.6	0.3	0.8	0.1	-0.0	-0.3	0.6
Heel T-Score	0.4	2.9	9.3	-1.2	-0.8	2.9	0.7	1.6	3.0	1.5	1.4	1.1	-1.0	1.5
Number of treatments/medications taken	0.4	0.7	1.9	-0.2	0.7	-0.6	0.1	-0.1	-1.4	0.7	1.2	1.4	-1.1	0.4
Relative age of first facial hair	0.4	0.9	2.4	1.5	0.8	-0.9	-0.1	0.3	0.2	1.6	0.2	-1.1	1.4	0.5
Townsend deprivation index at recruitment	0.4	0.5	1.5	0.3	0.6	0.8	0.9	0.9	0.1	1.2	1.0	-0.3	-0.2	-0.3
High blood pressure (mother)	0.4	0.6	2.1	0.5	0.4	-1.5	-0.6	-0.7	-0.2	1.1	-1.2	-0.6	-0.4	-0.2
Hair/balding pattern: Pattern 2	0.4	0.6	2.9	0.8	0.0	-0.3	0.1	0.3	-1.2	-0.2	-0.6	0.7	0.4	1.7
Forced vital capacity (FVC)	0.4	1.6	3.5	-0.8	-1.2	1.5	0.9	1.7	1.6	0.7	-0.7	0.4	1.9	1.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.8	0.8	0.3	1.3	0.8	1.1	0.9	0.3	0.2	0.5	-0.5	-0.3
Medication: Simvastatin	0.4	0.5	2.6	0.1	0.6	0.0	-0.3	-0.2	0.5	-0.3	1.6	-0.2	-1.2	-1.1
Illnesses of siblings	0.4	0.5	2.6	-0.0	-0.8	-0.3	0.1	-0.2	0.5	-1.6	-1.0	-0.0	0.9	0.8
Hair/balding pattern: Pattern 4	0.4	1.1	7.6	0.3	0.6	0.2	-0.2	0.2	0.4	-1.4	1.0	2.8	0.6	-0.4
Blood clot in the leg (DVT)	0.4	0.6	2.2	-0.3	1.1	-0.3	-0.3	0.3	-1.5	0.1	-1.0	-0.3	-0.2	1.1
Headache pain in last month	0.4	0.8	2.5	-0.1	-1.6	1.3	0.9	1.0	1.3	-0.4	-0.1	0.2	0.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.6	-0.9	-0.1	0.7	1.2	1.3	0.7	1.0	0.2	1.6	-0.8	0.5
Wheeze or whistling in the chest in last year	0.4	0.7	2.2	-1.0	-1.1	0.6	-0.1	-0.8	0.5	-0.5	0.8	-1.5	-0.8	-0.6
Age at first live birth	0.4	0.8	2.0	0.6	1.1	0.1	0.1	1.3	0.5	1.4	-0.1	1.0	1.2	0.9
Migraine (self-reported)	0.4	0.5	2.9	1.7	0.3	0.5	1.1	0.4	-0.2	-1.1	0.4	-0.0	0.2	-0.0
Heart disease (mother)	0.4	0.5	2.4	-0.3	-0.3	-0.0	-0.0	-0.6	1.1	1.6	-0.7	0.5	-0.3	-0.5
Pulse rate, automated reading	0.4	1.2	4.1	-0.8	0.4	1.9	1.1	0.3	0.3	0.5	2.0	0.3	-1.6	-1.1
Comparative height size at age 10	0.4	2.2	5.6	1.6	-0.3	-1.7	-1.4	-0.4	0.4	-0.9	-1.9	-2.4	2.3	0.8
Illnesses of siblings: Diabetes	0.4	0.5	1.7	-1.3	-0.9	0.2	-0.6	0.0	0.9	-0.9	-0.0	-0.6	-1.0	0.4
Back pain experienced in last month	0.4	0.6	2.1	-0.2	-1.3	-0.6	-0.2	-0.3	-1.5	0.8	0.5	-0.9	-0.1	0.0
Mineral and other dietary supplements	0.4	0.5	1.3	0.2	0.5	1.0	0.3	1.0	-0.9	0.4	1.1	-0.3	-0.8	-0.1
Asthma (self-reported)	0.4	0.8	3.0	-0.9	-1.6	0.2	0.1	-0.6	-0.6	-0.3	0.1	-1.7	-0.7	-1.0
Heart disease (siblings)	0.4	0.5	2.4	0.4	0.4	-0.3	-0.1	0.0	-0.3	1.5	-0.1	-0.2	-1.2	-1.2
Irritable Bowel Disease (IBD)	0.3	0.7	1.8	1.3	1.3	0.4	0.3	0.7	0.8	0.3	1.3	0.1	-0.8	0.8
Reaction Time	0.3	0.5	1.1	0.6	0.4	0.5	1.0	1.0	0.3	0.2	0.1	-1.0	-1.0	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.4	0.1	0.5	-1.2	-0.7	-0.6	0.9	0.1	0.4	0.6	2.1	0.8
Body Mass Index (BMI) (2010)	0.3	0.5	1.7	0.2	0.4	-0.8	-1.2	-1.3	-0.5	-0.3	-0.1	-0.0	0.4	0.6
Crohns Disease (2012)	0.3	0.5	1.6	1.3	0.2	-0.8	0.0	-0.2	0.9	-1.2	0.2	0.6	0.6	0.6
Systolic Blood Pressure	0.3	1.6	4.2	-0.0	-1.6	1.3	1.1	1.0	0.9	0.9	1.4	-0.9	-2.0	-1.4
Allergy or Eczema	0.3	0.9	3.3	-0.8	-1.3	-0.6	-0.8	-1.1	0.6	-0.2	-0.5	-1.8	0.6	0.7
Lung FEV1/FVC ratio	0.3	1.5	5.2	0.0	0.2	1.4	0.8	1.1	2.1	2.3	1.3	0.8	-0.4	-0.6
Lung FVC	0.3	1.7	4.3	-1.0	0.6	1.0	0.4	1.2	-0.1	1.6	-1.4	2.1	1.6	1.9
Chronotype (morning person)	0.3	0.7	2.7	0.4	0.3	0.6	1.1	0.3	1.6	-0.6	1.6	0.5	0.3	0.3
Vitamin and mineral supplements	0.3	0.4	1.8	0.1	0.3	-1.0	-0.4	0.1	-0.0	-0.8	-1.3	-0.1	0.6	0.7
Diabetes (father)	0.3	0.4	2.5	-0.0	0.2	0.5	0.4	0.3	-0.5	1.6	0.8	0.0	0.1	-0.0
Current tobacco smoking	0.3	0.5	1.8	0.4	-0.9	0.0	0.2	-0.2	-1.3	-1.0	0.8	0.2	-0.8	0.2
Taking other prescription medications	0.3	0.5	1.3	-1.1	-0.4	0.4	0.5	0.5	-0.1	0.9	0.4	0.8	-1.1	0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	-0.5	-0.3	-0.7	-1.0	-0.3	0.3	0.5	0.5	0.7	0.9	-0.1
Medication: Levothyroxine sodium	0.3	0.5	1.3	-1.1	-1.0	-0.8	0.0	0.2	-0.4	0.3	-0.8	0.2	-0.0	1.1
Sitting height	0.3	1.9	10.8	-0.3	-1.6	-0.6	-1.1	0.0	-0.2	-1.0	-0.3	-3.3	1.6	1.5
Impedance of leg (left)	0.3	1.4	5.2	-1.4	-1.3	2.3	1.7	1.4	0.0	0.1	-0.0	-0.2	-0.8	0.7
Time employed in main current job	0.3	0.3	1.2	0.2	0.2	-0.2	-0.7	-1.1	-0.3	0.3	-0.9	-0.7	-0.3	0.0
Asthma	0.3	0.7	2.7	-0.8	-1.4	0.3	0.2	-0.5	-0.5	-0.4	0.3	-1.6	-0.7	-0.8
Leg fat percentage (right)	0.3	1.0	1.9	0.1	0.8	1.2	1.2	0.7	0.7	1.1	0.7	0.8	-1.3	-1.4
Comparative body size at age 10	0.3	0.9	3.3	0.4	1.8	-1.0	-1.0	-0.7	0.0	0.8	1.1	1.2	0.9	-0.2
Number of full brothers	0.3	0.3	0.9	-1.0	-0.7	0.1	-0.8	0.1	0.2	-0.0	1.0	-0.8	0.1	-0.2
Neck or shoulder pain in last month	0.3	0.4	1.3	0.7	-0.4	0.2	0.4	0.1	-0.9	-1.0	1.1	-0.4	0.4	0.5
Medication: Seretide 50 evohaler	0.3	0.4	1.5	0.6	-0.7	-0.7	-0.3	-0.3	-0.6	-0.3	0.1	-1.2	0.4	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	0.8	0.7	0.3	-0.2	0.2	-0.6	-0.8	0.9	-0.5	0.6	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.3	-0.7	-0.6	0.0	0.3	0.1	-0.0	-0.9	-0.3	0.7	0.6	1.1
Average weekly champagne plus white wine intake	0.3	0.5	1.4	-1.1	-0.7	0.1	0.4	-0.3	-0.7	-0.2	0.2	-1.2	0.3	1.0
Hearing aid user	0.3	0.4	1.7	-0.0	-0.9	0.6	0.2	0.7	0.7	-0.3	-0.2	1.3	0.1	0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	2.4	0.1	0.2	-0.4	-0.2	-0.2	1.6	0.7	-0.8	0.1	0.7	0.5
Leg fat percentage (left)	0.3	1.0	2.2	0.1	0.5	1.4	1.5	1.2	1.0	0.8	0.4	0.5	-1.5	-0.9
Crohns Disease (2017)	0.2	0.4	2.7	0.5	0.5	-0.3	-0.1	0.2	0.3	-0.7	0.0	-0.3	0.3	1.6
Mean Putamen Volume	0.2	0.2	1.5	-0.2	-0.5	-0.1	-0.1	-0.1	-0.2	-1.2	0.2	-0.3	-0.6	-0.2
Waist Hip Ratio (WHR)	0.2	0.8	2.4	-0.5	-0.0	1.3	1.0	0.9	-1.1	-0.3	0.2	0.3	-1.6	-0.9
Systolic blood pressure, automated reading	0.2	0.7	3.5	0.8	-0.9	0.5	0.6	0.2	0.1	0.4	0.6	-0.3	-1.9	-1.3
Impedance of leg (right)	0.2	0.9	3.8	-1.2	-0.8	2.0	1.3	0.8	-0.4	0.6	0.6	0.3	-0.7	-0.1
Body mass index (BMI)	0.2	0.7	1.7	1.3	1.3	0.3	0.5	0.7	0.9	0.7	0.6	0.1	-1.0	-1.1
Waist circumference	0.2	0.6	1.7	1.1	0.8	0.7	1.0	1.1	0.4	-0.3	0.3	0.2	-1.3	-0.4
Impedance of arm (right)	0.2	1.0	2.7	-0.5	-0.4	1.6	1.6	1.1	-0.4	-0.4	0.4	1.0	-1.7	0.5
Arm fat percentage (right)	0.2	0.8	2.7	0.8	1.0	0.9	1.0	0.9	0.4	0.5	1.1	0.4	-1.6	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	1.1	-0.1	-0.8	-0.5	-0.3	-1.0	0.5	0.2	0.5	0.0	-0.3	-1.0
Mouth/teeth dental problems: Dentures	0.2	0.4	1.9	-0.1	0.3	0.7	0.8	0.7	0.3	0.5	-0.6	0.1	-0.4	1.4
Impedance of arm (left)	0.2	1.0	3.3	-0.7	-1.4	1.3	1.1	0.5	-0.4	-1.8	0.1	0.9	-0.8	0.9
Arm fat mass (right)	0.2	0.7	1.4	1.2	0.9	0.6	0.7	1.0	1.0	0.4	0.9	-0.3	-1.0	-0.5
Standing height	0.2	2.0	6.5	0.5	-1.7	-0.8	-0.5	0.4	0.4	-1.9	-0.5	-2.5	1.6	2.1
Medication: Paracetamol	0.2	0.3	1.1	-0.4	0.1	0.7	-0.3	0.4	0.5	0.1	1.0	-0.2	-0.2	1.1
Body fat percentage	0.2	0.7	1.7	0.5	0.5	1.0	1.1	0.8	1.0	-0.0	0.7	0.4	-1.3	-0.7
Arm fat-free mass (right)	0.2	1.1	5.4	0.9	-0.1	-1.2	-1.1	-0.2	0.5	-0.4	-0.4	-2.3	1.4	0.5
Exposure to tobacco smoke outside home	0.2	0.2	1.0	0.1	-0.2	-0.3	0.1	-0.6	-0.7	0.1	-0.6	-1.0	0.5	-0.2
Shortness of breath walking on level ground	0.2	0.3	1.0	0.4	-0.7	0.8	0.7	-0.1	-0.2	-1.0	-0.1	0.3	-0.2	0.5
Mean time to correctly identify matches	0.2	0.3	1.0	0.4	0.3	0.1	0.5	0.8	1.0	0.5	0.1	-0.0	-0.9	-0.2
Whole body fat mass	0.2	0.6	1.5	1.1	0.9	0.5	0.8	0.8	1.2	-0.1	0.7	-0.0	-1.0	-0.5
Leg fat mass (right)	0.2	0.7	1.1	0.8	1.0	0.9	0.8	0.9	1.0	0.7	0.7	-0.0	-1.1	-0.8
Arm predicted mass (right)	0.2	0.9	3.5	1.0	-0.2	-1.2	-1.1	-0.3	0.6	-0.8	-0.3	-1.9	1.4	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.9	0.2	0.3	-0.2	0.1	-0.4	1.4	0.6	0.1	0.6	0.3	-0.0
Medication: Paracetamol	0.2	0.3	1.1	-0.3	0.1	-0.0	-1.0	-0.1	0.3	0.4	0.5	-0.8	0.4	1.0
Cholesterol lowering medication	0.2	0.3	1.1	-0.5	-0.1	-0.1	0.0	-0.6	0.1	-0.5	1.1	-0.4	-0.6	-0.8
Impedance of whole body	0.2	1.0	3.0	-1.3	-1.6	1.7	1.4	0.8	-0.2	-0.9	-0.0	0.2	-0.7	0.6
Leg fat mass (left)	0.2	0.7	1.5	0.8	0.8	0.9	0.9	1.1	1.2	0.4	0.4	-0.1	-1.2	-0.5
Arm predicted mass (left)	0.2	0.9	4.8	1.1	0.3	-0.9	-0.8	0.3	0.6	0.1	0.2	-2.2	0.9	0.8
Blood Eosinophil Count	0.1	0.9	5.2	-0.4	-1.5	0.8	-0.6	-0.8	-0.4	-2.3	-0.0	0.5	0.4	-0.0
Blood Platelet Count	0.1	1.6	3.9	-1.2	-1.6	1.5	-0.9	-0.4	-0.5	-1.7	1.4	1.2	-0.5	2.0
BMI	0.1	0.6	4.1	-0.0	-0.2	0.7	0.1	0.3	1.0	0.2	2.0	0.5	-0.4	-0.7
Height	0.1	2.3	6.5	1.4	-1.6	0.1	1.7	1.6	0.1	-1.9	-1.4	-2.5	0.2	1.6
Hair Pigment	0.1	1.5	3.9	1.0	0.7	1.0	2.0	1.7	-1.5	1.4	-0.1	0.4	-1.4	-1.0
Leg fat-free mass (left)	0.1	0.6	2.0	1.4	0.4	-1.0	-0.6	0.1	0.6	-0.4	0.1	-1.4	0.5	0.0
Trunk fat percentage	0.1	0.5	1.3	0.5	0.1	0.9	1.0	0.9	1.2	-0.5	0.7	0.2	-1.0	-0.3
Leg predicted mass (left)	0.1	0.6	2.0	1.4	0.4	-1.0	-0.6	0.2	0.7	-0.4	0.1	-1.4	0.5	0.1
Trunk fat mass	0.1	0.5	1.3	0.9	0.3	0.6	0.9	0.9	1.1	-0.5	0.6	-0.3	-0.7	-0.1
Weight	0.1	0.5	1.9	1.4	0.6	0.0	0.3	0.9	1.0	-0.2	0.4	-0.9	-0.2	-0.0
Trunk fat-free mass	0.1	0.7	3.3	1.1	0.2	-0.9	-0.7	0.4	-0.1	0.1	0.0	-1.8	0.9	0.9
Trunk predicted mass	0.1	0.7	3.0	1.1	0.2	-0.9	-0.7	0.4	-0.1	0.1	0.1	-1.7	1.0	0.9
Whole body fat-free mass	0.1	0.7	3.3	1.3	0.3	-0.9	-0.7	0.4	0.2	-0.2	0.0	-1.8	0.8	0.5
Leg fat-free mass (right)	0.1	0.7	3.0	1.3	0.1	-0.8	-0.5	0.5	0.8	-0.5	-0.2	-1.7	0.5	0.5
Arm fat percentage (left)	0.1	0.5	1.6	0.7	0.6	0.8	0.9	0.5	0.5	-0.2	0.7	0.4	-1.3	-0.7
Whole body water mass	0.1	0.7	3.4	1.3	0.1	-0.9	-0.7	0.3	0.4	-0.2	0.1	-1.8	0.8	0.6
Leg predicted mass (right)	0.1	0.7	2.7	1.3	0.1	-0.8	-0.5	0.5	0.8	-0.6	-0.2	-1.6	0.5	0.6
Arm fat mass (left)	0.1	0.5	1.3	1.1	0.7	0.4	0.5	0.6	1.0	-0.1	0.8	-0.2	-0.8	-0.4
Basal metabolic rate	0.1	0.6	3.2	1.3	0.2	-0.7	-0.5	0.5	0.6	-0.2	0.1	-1.8	0.6	0.4
Arm fat-free mass (left)	0.1	0.7	2.7	1.2	0.5	-0.8	-0.8	0.4	0.6	0.2	0.2	-1.6	1.0	0.6
Tanning	0.0	0.4	1.6	-0.4	-1.3	0.1	0.5	-0.4	-1.0	-0.7	0.1	-0.7	-0.6	-0.3
Hip circumference	0.0	0.2	1.0	1.0	-0.1	-0.3	-0.1	0.0	0.8	-0.1	0.1	-0.6	0.0	0.1

Hub : Genes

ACO1

Models

Trait associations