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chr1:92,277,843-94,534,354

Best TWAS P=3.5e-14 · Best GWAS P=6.32e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	DR1	0.10	0.09	blup	29	0.08	3.9e-09	7.5	7.6	3.5e-14	0.98	0.00	1.00	TRUE
51	GTEx	Pancreas	FAM69A	0.10	0.08	enet	12	0.04	1.1e-02	5.5	5.7	9.3e-09	-0.03	0.25	0.04	TRUE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	DR1	0.03	0.03	blup	29	0.03	1.1e-04	7.5	7.5	4.5e-14	0.98	0.00	0.99	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	DR1	0.04	0.04	lasso	3	0.04	1.5e-08	7.5	7.5	5.9e-14	0.98	0.00	1.00	FALSE
88	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DR1	0.09	0.09	lasso	2	0.07	4.7e-04	7.5	7.5	6.3e-14	1.00	0.00	0.93	FALSE
86	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DR1	0.03	0.02	blup	29	0.02	3.2e-03	7.1	7.4	1.2e-13	0.98	0.00	0.96	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DR1	0.05	0.05	blup	29	0.06	4.1e-07	7.2	7.3	2.0e-13	0.95	0.01	0.99	FALSE
73	YFS	Blood	DR1	0.11	0.17	lasso	17	0.19	2.0e-58	7.5	7.3	2.1e-13	0.95	0.00	1.00	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	DR1	0.16	0.18	blup	29	0.19	4.1e-18	7.2	7.2	4.9e-13	0.95	0.01	0.99	FALSE
30	GTEx	Cells Transformed fibroblasts	DR1	0.18	0.21	enet	18	0.24	6.0e-18	5.3	7.2	5.1e-13	0.82	0.67	0.33	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	TMED5	0.11	0.10	enet	17	0.13	2.7e-16	6.4	-7.2	7.4e-13	-0.82	0.06	0.94	FALSE
6	GTEx	Adipose Visceral Omentum	DR1	0.10	0.05	lasso	5	0.06	5.0e-04	6.6	7.2	8.0e-13	0.84	0.05	0.94	FALSE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	DR1	0.07	0.05	enet	9	0.07	6.2e-06	7.1	7.1	9.7e-13	0.92	0.01	0.99	FALSE
60	GTEx	Testis	TMED5	0.27	0.31	lasso	5	0.30	6.9e-14	7.0	-7.1	1.2e-12	-0.95	0.05	0.95	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TMED5	0.06	0.07	enet	20	0.09	6.7e-11	6.4	-7.0	1.8e-12	-0.90	0.05	0.95	FALSE
29	GTEx	Cells Transformed fibroblasts	TMED5	0.10	0.11	lasso	3	0.09	4.6e-07	7.0	-7.0	1.9e-12	-0.92	0.08	0.92	FALSE
80	The Cancer Genome Atlas	Glioblastoma Multiforme	TMED5	0.08	0.05	blup	39	0.03	4.7e-02	7.1	-7.0	2.9e-12	-0.95	0.01	0.72	FALSE
13	GTEx	Artery Tibial	DR1	0.17	0.11	lasso	8	0.18	5.9e-14	7.1	6.9	4.0e-12	0.88	0.03	0.97	FALSE
71	ROSMAP	Brain Pre-frontal Cortex	DR1	0.09	0.12	enet	20	0.16	1.2e-20	5.2	6.8	1.5e-11	0.86	0.26	0.74	FALSE
24	GTEx	Brain Putamen basal ganglia	RP4-717I23.3	0.38	0.34	enet	37	0.34	9.1e-09	5.4	-6.7	1.6e-11	-0.69	0.47	0.50	FALSE
9	GTEx	Artery Aorta	DR1	0.15	0.10	lasso	5	0.14	3.1e-08	5.3	6.7	2.2e-11	0.85	0.09	0.91	FALSE
87	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMED5	0.05	0.05	enet	11	0.04	9.7e-04	6.6	-6.7	2.2e-11	-0.83	0.02	0.84	FALSE
90	The Cancer Genome Atlas	Soft Tissue Sarcoma	DR1	0.10	0.03	lasso	4	0.06	3.2e-04	5.3	6.7	2.3e-11	0.85	0.02	0.92	FALSE
38	GTEx	Esophagus Muscularis	CCDC18	0.06	0.05	lasso	4	0.04	2.8e-03	6.5	-6.6	3.3e-11	-0.76	0.16	0.71	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMED5	0.08	0.06	enet	12	0.07	3.5e-08	7.1	-6.6	4.1e-11	-0.83	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	DR1	0.05	0.03	blup	29	0.03	1.3e-04	6.4	6.6	4.4e-11	0.85	0.02	0.82	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DR1	0.21	0.20	blup	305	0.23	1.8e-27	7.1	6.5	7.5e-11	0.83	0.03	0.97	FALSE
35	GTEx	Esophagus Gastroesophageal Junction	RP4-717I23.3	0.31	0.26	lasso	17	0.30	1.4e-11	5.2	-6.5	8.9e-11	-0.81	0.22	0.78	FALSE
57	GTEx	Spleen	CCDC18	0.29	0.07	lasso	10	0.15	9.2e-05	7.1	-6.5	9.5e-11	-0.89	0.02	0.95	FALSE
64	METSIM	Adipose	CCDC18	0.08	0.06	lasso	4	0.07	4.9e-10	5.8	-6.4	1.3e-10	-0.76	0.98	0.02	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DR1	0.03	0.03	lasso	1	0.03	3.2e-04	6.4	6.4	1.7e-10	0.78	0.01	0.79	FALSE
75	YFS	Blood	TMED5	0.14	0.19	lasso	16	0.22	1.1e-69	5.4	-6.4	1.9e-10	-0.85	1.00	0.00	FALSE
18	GTEx	Brain Cerebellum	RP4-717I23.3	0.48	0.53	enet	32	0.57	2.9e-20	5.2	-6.3	2.1e-10	-0.80	0.84	0.16	FALSE
48	GTEx	Nerve Tibial	CCDC18	0.06	0.04	lasso	11	0.04	7.2e-04	6.4	-6.2	4.0e-10	-0.82	0.04	0.91	FALSE
69	NTR	Blood	TMED5	0.01	0.01	blup	277	0.01	5.2e-04	6.4	-6.1	9.2e-10	-0.79	0.04	0.92	FALSE
4	GTEx	Adipose Subcutaneous	DR1	0.18	0.14	lasso	6	0.12	3.7e-10	5.3	6.1	9.5e-10	0.74	0.93	0.07	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LOC100131564	0.39	0.53	bslmm	315	0.54	9.6e-78	5.4	-6.1	1.1e-09	-0.70	1.00	0.00	FALSE
49	GTEx	Nerve Tibial	RP4-717I23.3	0.43	0.46	enet	39	0.54	1.0e-44	5.3	-6.1	1.1e-09	-0.75	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMED5	0.06	0.00	enet	7	0.01	2.5e-02	-3.5	-6.1	1.2e-09	-0.58	0.02	0.42	FALSE
40	GTEx	Heart Atrial Appendage	DR1	0.10	0.06	lasso	4	0.05	2.8e-03	6.4	6.0	1.4e-09	0.71	0.10	0.80	FALSE
39	GTEx	Esophagus Muscularis	RP4-717I23.3	0.31	0.38	lasso	5	0.42	2.0e-27	5.2	-6.0	2.0e-09	-0.76	1.00	0.00	FALSE
44	GTEx	Lung	DR1	0.07	0.07	lasso	4	0.06	2.4e-05	5.8	6.0	2.2e-09	0.70	0.26	0.73	FALSE
32	GTEx	Colon Sigmoid	RP4-717I23.3	0.28	0.30	lasso	8	0.33	2.4e-12	5.3	-6.0	2.3e-09	-0.72	0.90	0.10	FALSE
79	The Cancer Genome Atlas	Colon Adenocarcinoma	DR1	0.36	0.06	enet	9	0.06	2.2e-04	6.4	6.0	2.3e-09	0.71	0.01	0.92	FALSE
63	GTEx	Vagina	RP4-717I23.3	0.26	0.13	lasso	7	0.09	3.8e-03	5.2	-5.9	3.0e-09	-0.65	0.14	0.43	FALSE
7	GTEx	Adipose Visceral Omentum	RP4-717I23.3	0.28	0.32	enet	19	0.34	1.4e-18	5.3	-5.9	3.1e-09	-0.72	1.00	0.00	FALSE
92	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMED5	0.05	0.06	lasso	2	0.05	1.4e-04	5.9	-5.9	4.1e-09	-0.91	0.02	0.94	FALSE
68	NTR	Blood	DR1	0.01	0.01	blup	304	0.01	6.5e-03	6.6	5.8	5.1e-09	0.71	0.04	0.85	FALSE
54	GTEx	Prostate	RP4-717I23.3	0.46	0.46	lasso	10	0.45	1.1e-12	5.8	-5.8	7.5e-09	-0.62	0.89	0.11	FALSE
19	GTEx	Brain Cortex	RP4-717I23.3	0.39	0.37	enet	19	0.42	1.0e-12	5.8	-5.7	1.0e-08	-0.67	0.93	0.07	FALSE
33	GTEx	Colon Transverse	DR1	0.14	0.14	lasso	5	0.10	1.7e-05	5.2	5.7	1.0e-08	0.70	0.35	0.63	FALSE
17	GTEx	Brain Cerebellar Hemisphere	RP4-717I23.3	0.44	0.40	lasso	6	0.48	5.8e-14	4.8	-5.7	1.2e-08	-0.76	0.48	0.52	FALSE
22	GTEx	Brain Hypothalamus	RP4-717I23.3	0.33	0.35	enet	25	0.37	1.1e-09	5.8	-5.7	1.2e-08	-0.66	0.56	0.44	FALSE
53	GTEx	Pituitary	RP4-717I23.3	0.53	0.44	lasso	11	0.47	1.8e-13	5.3	-5.7	1.3e-08	-0.71	0.93	0.07	FALSE
61	GTEx	Thyroid	RP4-717I23.3	0.41	0.44	lasso	10	0.49	1.8e-42	5.3	-5.7	1.3e-08	-0.67	1.00	0.00	FALSE
72	ROSMAP	Brain Pre-frontal Cortex	RP4-717I23.3	0.33	0.57	lasso	9	0.58	2.6e-92	5.3	-5.7	1.3e-08	-0.69	1.00	0.00	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	RP4-717I23.3	0.50	0.42	lasso	5	0.47	3.0e-14	5.4	-5.7	1.5e-08	-0.66	0.95	0.05	FALSE
59	GTEx	Stomach	RP4-717I23.3	0.33	0.35	lasso	8	0.38	2.5e-19	5.3	-5.7	1.5e-08	-0.73	1.00	0.00	FALSE
21	GTEx	Brain Hippocampus	RP4-717I23.3	0.28	0.24	lasso	7	0.22	8.0e-06	5.4	-5.6	1.8e-08	-0.64	0.44	0.47	FALSE
36	GTEx	Esophagus Mucosa	RP4-717I23.3	0.23	0.27	lasso	2	0.29	1.5e-19	5.8	-5.6	1.8e-08	-0.62	1.00	0.00	FALSE
14	GTEx	Artery Tibial	RP4-717I23.3	0.22	0.32	lasso	11	0.36	9.0e-30	5.3	-5.6	1.9e-08	-0.72	1.00	0.00	FALSE
41	GTEx	Heart Atrial Appendage	RP4-717I23.3	0.30	0.25	lasso	6	0.27	1.3e-12	5.3	-5.6	2.0e-08	-0.64	1.00	0.00	FALSE
47	GTEx	Nerve Tibial	DR1	0.10	0.08	lasso	4	0.07	8.8e-06	5.3	5.6	2.1e-08	0.66	0.74	0.24	FALSE
37	GTEx	Esophagus Muscularis	DR1	0.12	0.06	lasso	7	0.07	6.6e-05	5.4	5.6	2.5e-08	0.72	0.20	0.66	FALSE
20	GTEx	Brain Frontal Cortex BA9	RP4-717I23.3	0.48	0.53	lasso	12	0.53	1.6e-16	5.4	-5.6	2.6e-08	-0.68	0.79	0.21	FALSE
50	GTEx	Ovary	RP4-717I23.3	0.44	0.43	lasso	7	0.42	1.5e-11	5.2	-5.5	3.0e-08	-0.63	0.98	0.02	FALSE
62	GTEx	Uterus	RP4-717I23.3	0.23	0.16	enet	14	0.17	2.7e-04	5.2	-5.5	3.1e-08	-0.63	0.24	0.27	FALSE
28	GTEx	Cells EBV-transformed lymphocytes	RP4-717I23.3	0.32	0.36	lasso	10	0.36	9.8e-13	5.2	-5.5	3.3e-08	-0.68	0.96	0.04	FALSE
11	GTEx	Artery Coronary	EVI5	0.09	0.10	lasso	2	0.07	3.1e-03	5.5	5.5	4.3e-08	-0.09	0.18	0.17	FALSE
52	GTEx	Pancreas	RP4-717I23.3	0.28	0.32	lasso	8	0.32	4.0e-14	5.2	-5.5	4.6e-08	-0.64	1.00	0.00	FALSE
26	GTEx	Breast Mammary Tissue (Male)	RP4-717I23.3	0.29	0.23	lasso	8	0.21	1.5e-05	5.2	-5.5	4.7e-08	-0.63	0.38	0.11	FALSE
65	METSIM	Adipose	FAM69A	0.03	0.03	bslmm	293	0.02	1.8e-03	5.0	-5.5	5.1e-08	-0.07	0.67	0.01	FALSE
8	GTEx	Adrenal Gland	RP4-717I23.3	0.47	0.49	enet	30	0.53	5.5e-22	5.2	-5.5	5.2e-08	-0.61	1.00	0.00	FALSE
58	GTEx	Spleen	RP4-717I23.3	0.39	0.46	enet	22	0.48	5.3e-14	4.8	-5.4	5.3e-08	-0.63	0.99	0.01	FALSE
25	GTEx	Breast Mammary Tissue	RP4-717I23.3	0.30	0.32	enet	17	0.33	1.4e-17	5.3	-5.4	6.4e-08	-0.64	1.00	0.00	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	RP4-717I23.3	0.40	0.41	lasso	9	0.38	3.7e-22	5.3	-5.4	6.7e-08	-0.62	1.00	0.00	FALSE
56	GTEx	Skin Sun Exposed Lower leg	RP4-717I23.3	0.20	0.28	lasso	13	0.30	1.5e-25	5.3	-5.4	6.9e-08	-0.64	1.00	0.00	FALSE
10	GTEx	Artery Aorta	RP4-717I23.3	0.26	0.36	lasso	5	0.33	4.6e-19	5.3	-5.4	7.0e-08	-0.65	1.00	0.00	FALSE
15	GTEx	Brain Caudate basal ganglia	RP4-717I23.3	0.43	0.46	enet	24	0.48	9.2e-16	5.2	-5.4	7.3e-08	-0.66	0.99	0.01	FALSE
67	METSIM	Adipose	TMED5	0.05	0.07	lasso	17	0.06	2.4e-09	5.2	-5.4	8.0e-08	-0.64	1.00	0.00	FALSE
46	GTEx	Muscle Skeletal	RP4-717I23.3	0.17	0.19	enet	25	0.18	3.3e-17	5.3	-5.4	8.2e-08	-0.62	1.00	0.00	FALSE
66	METSIM	Adipose	RP4-717I23.3	0.21	0.34	enet	34	0.34	3.0e-52	4.8	-5.4	8.3e-08	-0.65	1.00	0.00	FALSE
12	GTEx	Artery Coronary	RP4-717I23.3	0.14	0.17	lasso	5	0.17	3.1e-06	5.3	-5.3	1.2e-07	-0.64	0.53	0.35	FALSE
27	GTEx	Breast Mammary Tissue (Female)	RP4-717I23.3	0.19	0.20	lasso	13	0.19	2.1e-06	5.3	-5.3	1.3e-07	-0.64	0.82	0.09	FALSE
42	GTEx	Heart Left Ventricle	RP4-717I23.3	0.20	0.25	lasso	5	0.26	3.1e-14	5.3	-5.3	1.3e-07	-0.64	1.00	0.00	FALSE
43	GTEx	Liver	RP4-717I23.3	0.22	0.21	lasso	8	0.16	3.6e-05	5.3	-5.3	1.3e-07	-0.61	0.64	0.03	FALSE
5	GTEx	Adipose Subcutaneous	RP4-717I23.3	0.34	0.39	lasso	7	0.44	2.5e-39	5.3	-5.3	1.4e-07	-0.64	1.00	0.00	FALSE
45	GTEx	Lung	RP4-717I23.3	0.38	0.36	lasso	9	0.36	3.9e-29	5.2	-5.3	1.4e-07	-0.64	1.00	0.00	FALSE
34	GTEx	Colon Transverse	RP4-717I23.3	0.25	0.28	lasso	5	0.23	2.0e-11	5.2	-5.2	1.5e-07	-0.64	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC18	0.08	0.08	lasso	1	0.05	7.7e-04	5.2	5.2	1.6e-07	0.65	0.40	0.13	FALSE
16	GTEx	Brain Cerebellar Hemisphere	TMED5	0.37	0.06	enet	21	0.11	1.1e-03	7.5	-5.2	1.9e-07	-0.87	0.02	0.94	FALSE
31	GTEx	Cells Transformed fibroblasts	RP4-717I23.3	0.25	0.30	lasso	3	0.33	3.8e-25	4.8	-5.1	2.8e-07	-0.64	1.00	0.00	FALSE
74	YFS	Blood	FAM69A	0.28	0.09	enet	29	0.13	4.9e-40	-3.4	-5.1	3.0e-07	-0.07	1.00	0.00	FALSE