TWAS hub - CCDC18

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0640	0.0280	5.9e-04	0.002	NA	0.006	NA	0.015	2.2e-01	NA	1.0e-01	NA	2.1e-02
2	GTEx	Brain Frontal Cortex BA9	0.1171	0.0602	8.3e-03	0.018	NA	0.037	NA	-0.011	1.1e-01	NA	3.7e-02	NA	8.4e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.3870	0.0920	8.8e-06	0.125	NA	0.140	NA	0.138	7.2e-05	NA	2.7e-05	NA	3.1e-05
4	GTEx	Colon Transverse	0.0970	0.0420	2.5e-03	0.038	NA	0.036	NA	0.030	6.3e-03	NA	8.0e-03	NA	1.4e-02
5	GTEx	Esophagus Muscularis	0.0630	0.0330	5.4e-03	0.046	NA	0.026	NA	0.036	8.5e-04	NA	1.0e-02	NA	2.8e-03
6	GTEx	Nerve Tibial	0.0613	0.0274	1.2e-03	0.038	NA	0.033	NA	0.041	9.8e-04	NA	2.0e-03	NA	7.2e-04
7	GTEx	Spleen	0.2860	0.0880	1.7e-05	0.075	NA	0.088	NA	0.154	5.7e-03	NA	3.0e-03	NA	9.2e-05
8	GTEx	Testis	0.1250	0.0590	8.9e-03	0.006	NA	-0.006	NA	-0.004	1.6e-01	NA	8.3e-01	NA	5.5e-01
9	METSIM	Adipose	0.0793	0.0284	7.4e-08	0.059	0.062	0.056	0.062	0.065	3.3e-09	1.5e-09	8.2e-09	1.3e-09	4.9e-10
10	NTR	Blood	0.0262	0.0101	5.4e-05	0.002	0.015	0.007	0.014	0.007	8.0e-02	1.1e-05	1.9e-03	1.4e-05	2.2e-03
11	TCGA	Breast Invasive Carcinoma	0.0439	0.0257	6.9e-05	0.017	0.023	0.017	NA	0.014	1.6e-04	1.1e-05	1.5e-04	NA	4.9e-04
12	TCGA	Colon Adenocarcinoma	0.0760	0.0480	1.1e-03	0.082	0.023	0.047	NA	0.049	1.8e-05	1.6e-02	1.1e-03	NA	7.7e-04
13	TCGA	Head and Neck Squamous Cell Carcinoma	0.0549	0.0286	3.6e-05	0.006	0.026	0.018	NA	0.013	6.4e-02	5.1e-04	3.8e-03	NA	1.1e-02
14	TCGA	Brain Lower Grade Glioma	0.0335	0.0224	1.8e-03	0.031	0.026	0.023	NA	0.026	1.7e-04	5.0e-04	1.1e-03	NA	5.5e-04
15	TCGA	Lung Squamous Cell Carcinoma	0.0559	0.0356	6.4e-04	0.008	0.018	0.012	NA	0.010	3.3e-02	3.6e-03	1.5e-02	NA	2.4e-02
16	TCGA	Prostate Adenocarcinoma	0.0318	0.0212	8.6e-03	0.016	0.018	0.015	NA	0.016	7.1e-03	4.6e-03	1.0e-02	NA	7.2e-03
17	TCGA	Soft Tissue Sarcoma	0.1290	0.0600	7.1e-06	0.044	0.097	0.094	NA	0.116	1.3e-03	2.1e-06	3.1e-06	NA	2.3e-07
18	TCGA	Thyroid Carcinoma	0.0560	0.0350	5.9e-03	0.002	0.014	0.001	NA	0.006	1.8e-01	1.6e-02	2.2e-01	NA	8.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Qualifications: College or University degree	7.3	22.9	67.6	3.4	3.8	1.0	6.3	6.5	6.7	8.2	4.1	6.7	3.7	2.7	-5.3	-1.1	7.0	-3.1	4.4	-0.6	-0.3
Average weekly red wine intake	7.1	10.5	24.1	1.5	4.9	3.1	4.9	2.7	3.4	4.4	3.3	4.1	4.0	2.1	-2.5	0.3	4.6	-0.5	3.2	1.0	1.7
Blood Eosinophil Count	6.0	46.1	108.2	7.0	5.0	2.1	7.2	8.7	9.8	9.5	4.1	10.4	10.4	-0.1	-9.0	-4.3	7.5	-5.7	2.2	-3.2	-1.0
Qualifications: None of the above	4.8	10.3	30.6	-1.4	-3.9	-2.4	-4.9	-2.4	-3.4	-5.5	-4.0	-2.8	-2.2	-3.5	1.8	-0.9	-5.0	0.6	-4.0	-1.2	-1.6
Medication: Paracetamol	4.8	8.0	20.1	-2.4	-1.3	0.2	-2.7	-4.3	-4.4	-4.5	-1.5	-4.3	-2.7	-0.2	3.9	1.9	-3.2	2.9	-1.3	1.7	1.3
HDL Cholesterol	4.5	7.4	20.5	-1.5	-1.7	-1.2	-3.5	-3.5	-3.7	-4.5	-2.7	-3.4	-2.9	-2.4	2.4	-0.1	-4.2	1.0	-3.2	-0.5	-0.4
Mood swings	4.4	7.9	21.0	-4.6	-1.7	1.4	-0.7	-3.3	-4.2	-2.7	0.2	-3.7	-2.9	1.7	4.1	3.1	-0.7	3.5	1.2	3.1	1.9
Ever had prostate specific antigen (PSA) test	4.3	4.9	9.9	-2.7	-0.5	1.8	0.4	-3.1	-2.4	-1.1	1.2	-2.3	-1.4	2.4	3.0	3.0	-0.0	3.1	1.6	2.9	2.8
Major Depression (MDD)	4.2	5.1	13.0	-1.3	-2.0	-2.0	-3.0	-0.5	-1.1	-3.0	-3.2	-1.0	-1.6	-3.1	0.5	-1.9	-3.6	-1.1	-3.3	-2.1	-2.2
Heart disease (mother)	4.0	4.9	12.7	3.6	0.7	-1.9	0.2	3.1	3.0	1.0	-1.2	3.1	1.5	-1.8	-2.8	-2.7	-0.1	-2.9	-1.4	-2.3	-2.0
Sensitivity / hurt feelings	3.6	6.2	14.5	-3.1	-1.8	1.8	-0.1	-3.8	-3.4	-2.0	0.5	-3.1	-2.3	2.0	3.7	2.7	-1.3	3.0	0.8	2.8	2.7
Chronic bronchitis/emphysema (mother)	3.6	4.2	10.2	2.1	-0.3	-3.2	-2.4	1.9	1.7	-0.5	-2.2	0.6	-0.6	-2.7	-1.6	-2.3	-1.4	-2.1	-2.1	-2.7	-3.1
Irritable Bowel Disease (IBD)	3.5	8.4	21.0	2.9	2.5	0.2	2.5	4.0	4.2	4.6	1.6	4.2	3.0	-0.0	-4.1	-2.2	3.0	-3.0	0.7	-1.9	-1.0
Crohns Disease (2017)	3.3	7.2	17.3	2.7	2.2	-0.5	1.9	4.2	3.6	3.5	0.6	4.2	2.5	-0.9	-3.9	-2.7	2.0	-3.3	-0.1	-2.3	-1.7
Mouth/teeth dental problems: Dentures	3.2	5.4	17.6	-0.7	-0.8	0.5	-2.9	-3.7	-3.4	-4.2	-2.1	-3.1	0.0	-1.3	2.5	0.6	-3.6	1.6	-2.5	0.4	0.9
Medication: Paracetamol	3.2	5.0	15.5	-1.9	-1.3	0.0	-2.5	-3.3	-3.4	-3.9	-1.6	-3.2	-1.6	-0.7	2.8	1.2	-2.7	2.1	-1.5	1.1	0.8
Number of incorrect matches in round	3.1	5.1	12.7	-0.8	-3.1	-1.4	-2.8	0.0	-0.7	-2.7	-3.0	-0.5	-1.4	-3.3	-0.1	-2.3	-3.6	-1.3	-3.4	-2.3	-2.4
Alcohol usually taken with meals	3.1	4.9	13.5	-0.4	2.6	2.0	3.6	1.6	1.5	3.5	2.9	2.0	1.1	2.4	-1.1	0.9	3.7	0.1	3.1	1.2	1.2
Rheumatoid Arthritis	3.0	4.1	13.7	-0.6	-1.2	0.3	-2.6	-3.7	-3.2	-2.9	-0.9	-3.7	-0.8	-0.6	2.4	1.1	-2.5	1.6	-1.2	0.6	0.3
Falls in the last year	3.0	4.0	9.1	-1.2	0.8	1.8	1.7	-2.0	-1.9	-0.0	1.6	-1.3	0.5	3.0	2.2	2.7	1.1	2.6	2.2	3.0	3.0
Qualifications: A levels/AS levels or equivalent	3.0	6.7	20.2	2.1	2.1	0.2	3.5	3.7	3.6	4.5	2.4	3.3	1.0	1.4	-2.6	-0.6	4.0	-1.6	2.7	-0.4	-0.5
Medication: Amlodipine	2.9	4.0	8.1	2.6	0.6	-1.2	-0.6	2.6	2.5	0.9	-1.1	2.3	0.7	-2.1	-2.7	-2.7	-0.3	-2.9	-1.8	-2.7	-2.3
Medication for pain relief, constipation, heartburn	2.9	5.0	12.8	1.2	0.5	0.3	2.1	3.3	3.3	3.5	1.0	3.6	2.0	0.1	-3.4	-1.6	2.5	-2.5	0.8	-1.5	-1.0
Family relationship satisfaction	2.9	3.6	9.7	1.0	1.6	1.7	2.7	1.5	2.0	2.9	2.5	1.4	1.5	2.1	-0.6	1.0	3.1	0.5	2.9	1.0	0.8
Hearing aid user	2.9	3.3	7.1	0.0	2.0	2.2	2.6	0.4	0.5	2.6	2.6	0.4	1.6	2.5	0.3	1.4	2.5	1.0	2.7	1.6	1.6
LDL Cholesterol	2.8	4.4	13.3	-3.3	-2.8	-0.5	-1.9	-2.5	-3.6	-2.8	-1.4	-2.6	-2.3	0.1	2.5	1.4	-1.7	1.6	-0.5	1.1	0.4
Hayfever, allergic rhinitis or eczema	2.7	5.9	17.6	-0.5	1.0	2.0	3.6	2.6	3.0	4.2	2.9	3.1	2.0	1.9	-2.1	0.2	4.0	-0.8	2.8	0.4	0.6
Mouth/teeth dental problems	2.6	3.9	13.0	2.2	-0.1	-1.4	0.5	3.6	2.4	2.1	-0.1	2.5	-0.0	-1.4	-2.6	-2.3	1.1	-2.6	-0.2	-2.3	-2.6
Neuroticism score	2.6	5.5	11.5	-3.4	-1.9	1.1	-0.8	-3.2	-3.0	-2.3	-0.0	-3.1	-3.1	1.4	3.3	2.5	-1.1	2.8	0.6	2.4	1.8
Noisy workplace	2.6	3.2	8.1	-1.7	-1.4	0.2	-2.0	-2.6	-2.8	-2.5	-0.9	-2.8	-1.7	-0.0	2.5	1.0	-2.1	1.5	-1.0	0.9	0.6
Qualifications: O levels/GCSEs or equivalent	2.6	4.1	9.9	0.3	2.7	2.0	3.1	-0.1	0.7	2.5	2.8	0.8	1.9	2.6	-0.0	1.5	3.0	0.8	2.6	1.8	2.2
Mean time to correctly identify matches	2.6	5.0	13.5	-3.2	-2.7	-1.1	-2.5	-2.2	-2.8	-2.8	-1.4	-3.2	-3.7	0.0	2.8	1.4	-2.0	1.8	-0.6	1.1	0.0
Worrier / anxious feelings	2.5	4.7	9.5	-2.9	-0.5	1.8	0.8	-2.7	-2.0	-0.8	1.4	-2.2	-1.2	2.5	2.7	3.0	0.8	2.9	2.0	3.1	2.6
Crohns Disease (2012)	2.4	3.8	12.0	2.1	1.6	0.5	2.4	2.3	2.4	3.5	1.7	2.6	2.6	0.7	-2.3	-0.9	2.5	-1.5	1.1	-0.6	0.1
Allergy or Eczema	2.4	6.4	19.5	-0.5	1.4	1.6	3.5	3.1	3.4	4.4	2.8	3.2	1.8	1.9	-2.4	0.0	4.2	-1.1	2.8	0.3	0.2
Migraine (self-reported)	2.4	3.0	6.0	-1.3	-1.2	1.4	0.6	-1.9	-1.9	-0.3	1.3	-2.1	-0.0	2.2	2.4	2.5	0.7	2.4	2.0	2.3	1.8
Friendships satisfaction	2.4	3.0	7.4	0.3	0.9	2.2	2.4	0.2	1.5	2.1	2.6	1.2	1.6	1.9	-0.6	1.3	2.7	0.8	2.4	1.3	1.7
Osteoporosis (self-reported)	2.4	3.0	7.1	1.7	0.4	-0.2	1.2	2.3	2.6	2.2	0.3	2.7	2.1	-0.5	-2.6	-1.9	1.0	-2.4	-0.3	-1.8	-1.0
Guilty feelings	2.4	3.7	7.8	-0.8	0.9	2.0	1.6	-0.8	-0.4	0.8	2.2	-0.8	-1.1	2.8	1.7	2.7	2.1	2.5	2.8	2.8	2.3
Blood Platelet Count	2.3	27.0	60.4	5.5	7.7	4.4	6.2	3.5	5.9	6.9	6.5	4.6	7.8	3.4	-3.3	1.4	7.5	0.5	5.6	1.6	2.2
Breastfed as a baby	2.3	2.9	9.8	0.4	3.1	1.4	2.8	0.7	0.9	1.8	2.1	1.0	0.9	1.9	0.0	1.1	2.5	0.6	2.2	1.6	1.5
High blood pressure (siblings)	2.3	3.3	8.0	2.8	1.1	-0.3	-0.3	1.6	2.1	0.3	-1.0	2.1	0.8	-2.4	-2.4	-2.6	-0.8	-2.3	-2.0	-2.4	-1.7
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.7	8.2	-1.4	-2.0	-0.1	-1.8	-2.9	-2.1	-2.5	-0.9	-2.3	-0.4	-0.3	2.0	0.8	-2.4	1.4	-1.2	0.6	1.0
Number of operations (self-reported)	2.3	3.4	7.9	-1.7	0.9	1.9	1.4	-1.2	-0.9	0.1	2.0	-1.1	-0.7	2.3	1.9	2.6	1.8	2.5	2.4	2.8	2.2
Depressed Affect (Nagel 2018)	2.2	4.6	8.8	-2.9	-2.1	0.4	-2.0	-2.9	-3.0	-2.8	-0.5	-2.9	-2.8	0.2	2.9	1.8	-1.7	2.5	-0.3	1.5	1.0
High blood pressure	2.2	6.2	14.7	3.6	2.8	1.7	2.1	2.8	3.7	2.5	1.2	3.8	3.7	-0.9	-3.2	-2.2	1.4	-2.0	-0.4	-1.6	-0.2
Comparative height size at age 10	2.2	12.0	32.4	-4.5	-4.9	-2.2	-4.0	-2.8	-3.7	-5.7	-4.6	-2.3	-3.2	-3.6	1.5	-1.1	-4.9	0.1	-4.5	-1.1	-0.9
Fasting Glucose	2.1	2.5	7.2	-1.7	-1.0	2.7	0.9	-2.5	-1.3	-0.3	1.8	-1.3	1.5	1.2	1.4	1.8	0.5	1.8	0.9	1.6	2.1
Depression (self-reported)	2.1	2.5	8.0	-0.7	-1.8	-0.4	-1.9	-0.8	-1.3	-1.9	-2.0	-0.8	-1.1	-2.0	0.2	-1.5	-2.8	-0.7	-2.5	-1.5	-1.0
Hypertension (Self-reported)	2.1	5.8	14.2	3.5	2.6	1.2	1.7	3.0	3.6	2.2	0.7	3.8	3.7	-1.3	-3.2	-2.4	1.2	-2.2	-0.7	-1.7	-0.6
Commuting to job workplace: Walk	2.1	2.2	5.8	1.0	0.2	0.4	1.2	2.1	2.1	2.0	0.6	2.4	1.9	-0.4	-2.3	-1.4	1.1	-1.7	0.2	-1.3	-0.9
Medication: Blood pressure	2.1	3.9	12.4	3.5	2.6	0.4	1.4	2.1	2.8	1.6	0.1	2.9	2.6	-0.9	-2.5	-2.1	0.4	-2.1	-0.9	-1.5	-0.4
Commuting to job workplace: Cycle	2.1	2.5	6.8	1.5	1.1	0.8	2.3	1.2	1.9	2.6	2.0	2.1	1.3	1.1	-1.8	-0.0	2.4	-0.7	1.6	0.1	0.6
Fluid intelligence score	2.0	4.2	13.6	-0.7	1.2	1.3	3.2	1.3	1.6	3.2	2.6	1.8	1.7	2.5	-1.0	1.1	3.7	0.2	2.9	1.4	1.5
Headache pain in last month	2.0	3.4	8.3	-2.9	-1.0	1.8	0.9	-2.4	-2.9	-1.3	0.5	-2.0	-0.5	1.4	2.6	2.0	-0.3	2.3	1.0	2.3	2.1
Ever highly irritable/argumentative for 2 days	1.9	2.3	5.6	-1.2	0.9	1.7	1.1	-0.6	-0.6	-0.1	1.5	-1.0	0.4	1.7	1.8	2.2	1.4	2.4	2.1	2.4	1.5
Neuroticism	1.8	4.2	8.4	-2.5	-2.4	0.5	-1.6	-2.7	-2.6	-2.7	-0.6	-2.9	-2.8	0.3	2.9	1.7	-1.6	2.3	-0.3	1.7	1.1
Illnesses of mother	1.8	2.2	6.8	-2.6	-1.7	0.8	-1.2	-2.0	-2.5	-2.0	-0.8	-1.9	-1.0	-0.4	1.5	0.3	-1.9	0.7	-1.1	0.2	0.4
Knee pain experienced in last month	1.8	2.7	9.1	-1.6	-1.3	0.7	-0.7	-3.0	-2.4	-2.5	-0.5	-1.9	-0.7	0.3	2.1	1.6	-1.2	2.0	-0.3	1.6	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	5.3	1.6	1.8	1.2	2.1	0.9	1.3	1.6	1.4	1.5	2.3	1.0	-0.7	0.1	1.6	0.0	1.1	0.6	1.1
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	9.5	-3.1	-0.8	0.7	0.5	-2.2	-1.5	-1.1	0.6	-1.5	-0.5	1.9	1.9	2.3	0.3	2.1	1.2	2.4	2.2
Vascular/heart problems diagnosed by doctor	1.8	4.9	14.6	-3.8	-2.7	-0.8	-1.2	-2.6	-3.3	-1.8	-0.6	-3.2	-3.1	1.3	2.8	2.2	-0.8	1.9	0.8	1.7	0.7
Blood Red Count	1.7	16.1	44.0	-2.0	-3.0	0.2	-4.2	-6.6	-6.2	-6.5	-2.2	-6.4	-2.0	-0.9	5.2	2.3	-5.0	3.9	-2.3	1.8	1.7
Hearing difficulty/problems: Yes	1.7	2.7	9.1	0.2	1.3	0.7	1.6	0.0	0.2	1.7	1.9	-0.0	-0.3	3.0	0.9	2.1	2.1	1.4	2.7	2.2	1.8
Medication: Metformin	1.7	2.4	5.8	0.2	-1.2	-1.9	-2.1	0.3	-0.1	-1.7	-2.3	-0.3	-0.6	-2.1	-0.2	-1.6	-2.1	-1.2	-2.4	-1.6	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.7	4.0	8.6	-1.5	-0.4	2.3	0.4	-2.4	-2.0	-0.8	1.6	-2.5	-1.4	2.2	2.9	2.6	-0.1	2.9	1.8	2.5	2.1
Allergy	1.7	3.9	10.9	0.9	-0.7	-1.8	-3.2	-2.0	-2.0	-3.3	-2.3	-2.5	-1.0	-1.8	1.3	-0.4	-3.2	0.3	-2.5	-0.7	-0.8
Pain all over the body in last month	1.7	1.8	7.2	-0.8	-2.7	-1.0	-1.8	-0.1	-1.1	-1.9	-1.7	-1.1	-0.7	-1.4	1.0	-0.5	-1.9	0.1	-1.2	-0.6	-1.4
Comparative body size at age 10	1.7	4.7	14.4	3.8	2.6	-0.0	0.9	3.2	3.2	1.5	0.1	3.0	3.1	-1.3	-2.5	-1.9	1.0	-1.9	-0.2	-1.5	-1.6
Pain type(s) experienced in last month: Hip pain	1.7	2.2	5.2	-1.1	1.5	1.1	0.6	-1.4	-1.2	-0.6	0.7	-1.2	-1.4	1.8	1.9	2.1	0.5	2.2	1.5	2.3	1.8
Ulcerative Colitis (UC)	1.6	3.1	10.5	1.7	1.6	0.6	1.6	1.8	2.7	3.2	1.7	2.1	1.9	0.7	-2.3	-0.7	2.3	-1.3	1.0	-0.7	0.1
Medication for hormone replacement therapy	1.6	1.8	4.1	-2.0	-0.7	1.7	0.2	-1.5	-1.5	-0.9	0.6	-1.3	0.4	1.0	1.8	1.7	-0.1	2.0	0.8	1.8	1.6
High blood pressure (mother)	1.6	2.2	6.1	1.7	2.0	0.1	2.0	1.4	2.0	2.0	0.8	2.5	1.9	0.4	-1.9	-0.7	1.6	-1.2	0.5	-0.3	0.5
Alcohol intake frequency.	1.6	3.8	16.6	-2.2	-4.1	-0.5	-1.4	-2.1	-2.5	-2.4	-0.6	-2.5	-2.5	0.2	2.5	1.2	-1.6	1.7	-0.2	1.2	0.5
Medication: Aspirin	1.6	2.2	7.5	2.2	2.7	0.2	1.2	2.0	2.0	2.2	1.1	1.7	1.1	0.2	-1.6	-0.7	1.6	-0.9	0.7	-0.6	-0.4
Alcohol drinker status: Previous	1.6	1.9	4.8	-0.1	-0.9	-2.1	-1.7	-0.6	-0.8	-1.7	-1.7	-0.8	-2.2	-1.4	0.3	-0.9	-2.0	-0.6	-1.7	-1.0	-1.2
Lupus	1.5	2.3	6.4	-0.9	0.2	1.7	0.0	-2.5	-2.1	-1.7	0.3	-1.4	0.1	0.9	1.9	1.7	-0.8	2.2	0.1	1.7	2.4
Prospective memory result	1.5	1.9	6.1	0.0	-1.5	-0.8	-1.9	-0.6	-1.0	-2.0	-1.5	-1.2	-2.5	-1.4	0.9	-0.6	-2.2	-0.1	-1.6	-0.7	-1.1
Number of full brothers	1.5	1.8	4.7	-0.7	1.1	2.2	1.6	-1.5	-0.6	0.3	1.6	-0.4	0.9	1.5	1.0	1.5	0.9	1.5	1.3	1.7	2.1
Age at first live birth	1.5	2.7	7.5	1.2	1.2	-0.1	2.0	2.7	2.2	2.6	1.0	2.5	-0.2	0.3	-2.1	-0.9	2.3	-1.6	1.2	-0.7	-0.8
Medication: Lisinopril	1.5	2.0	6.9	2.5	0.7	-0.1	0.7	1.6	2.0	1.5	0.6	1.6	2.6	-0.6	-1.8	-1.1	1.1	-1.2	-0.1	-1.0	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	5.4	0.1	-1.5	-1.2	-2.3	-0.9	-0.9	-2.1	-1.7	-1.2	-2.1	-1.3	0.6	-0.5	-2.3	0.0	-1.6	-0.8	-0.9
Neuroticism (Nagel 2018)	1.4	3.3	8.2	-2.4	-0.8	0.8	-0.9	-2.2	-2.4	-2.0	-0.0	-2.3	-2.9	0.8	2.7	1.9	-0.9	2.4	0.4	1.9	1.3
Reaction Time	1.4	2.6	10.5	-2.5	-3.1	-1.3	-1.7	-0.8	-1.6	-1.7	-1.2	-1.6	-3.2	-0.3	1.4	0.4	-1.4	0.6	-0.6	0.3	-0.5
Medication: Co-codamol	1.4	1.7	4.6	0.6	-0.7	-0.1	-1.5	-2.0	-1.9	-2.1	-1.1	-1.8	-1.3	-0.7	1.4	0.2	-1.9	0.7	-1.3	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	7.5	-1.2	-0.5	1.4	0.2	-1.9	-1.8	-0.6	1.4	-2.4	-1.5	2.0	2.7	2.5	0.1	2.7	1.9	2.2	1.6
Had menopause	1.4	1.7	4.2	-1.9	-0.6	0.3	-0.9	-1.4	-1.7	-1.1	0.2	-2.0	-1.1	0.9	1.9	1.8	0.0	2.0	0.8	1.5	0.8
Alcohol intake versus 10 years previously	1.4	2.1	5.3	0.2	-2.3	-1.6	-1.9	0.3	-0.1	-1.3	-1.8	-0.2	-1.2	-1.8	-0.4	-1.6	-1.8	-1.3	-2.3	-1.5	-1.5
Gout (self-reported)	1.4	1.9	5.6	1.6	1.4	0.1	1.2	1.8	2.4	1.9	1.3	2.1	1.2	-0.2	-2.0	-0.7	1.6	-0.9	0.6	-0.7	-0.4
Shortness of breath walking on level ground	1.4	1.6	4.7	2.0	0.2	-1.0	-0.4	1.5	2.2	0.7	0.1	1.2	1.0	-1.4	-1.8	-1.3	0.5	-1.2	-0.5	-1.6	-1.5
Suffer from ‘nerves’	1.4	2.2	5.4	-2.3	-2.1	-1.1	-1.8	-1.3	-1.7	-2.2	-1.5	-1.6	-1.8	-1.0	1.2	0.1	-1.8	0.5	-1.4	-0.0	-0.4
Wears glasses or contact lenses	1.4	1.6	3.6	-0.3	0.7	1.4	0.5	-1.9	-1.0	-0.6	1.1	-1.4	0.9	1.1	1.5	1.6	0.2	1.9	1.0	1.6	1.7
Mean Putamen Volume	1.3	1.5	4.2	0.2	1.0	0.9	1.6	1.1	1.4	2.0	1.8	0.8	1.1	1.2	-0.4	0.7	2.0	0.4	1.9	0.8	0.4
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.6	0.1	-1.5	-1.0	-2.2	0.9	0.1	-1.1	-1.5	-0.7	0.2	-1.9	-0.4	-1.1	-1.3	-0.6	-1.4	-1.3	-2.0
Average weekly fortified wine intake	1.3	1.5	3.8	-1.9	0.8	1.1	0.4	-1.4	-1.9	-0.7	0.3	-1.3	-0.6	1.1	1.5	1.5	0.4	1.6	0.7	1.7	1.5
Exposure to tobacco smoke outside home	1.3	1.7	4.8	0.7	-1.4	-1.2	-1.6	-0.5	-0.7	-2.1	-2.2	-0.3	-1.3	-1.4	0.3	-0.9	-2.2	-0.5	-2.0	-0.7	-0.6
Medication: Blood pressure	1.3	2.2	5.3	2.3	1.1	-0.6	-0.9	2.0	2.0	0.1	-0.5	1.4	0.7	-2.2	-1.6	-1.8	-0.3	-1.3	-1.3	-1.9	-2.0
Chest pain or discomfort	1.3	1.9	4.8	1.8	2.0	0.8	1.9	1.2	1.3	1.6	1.0	2.2	1.9	0.3	-1.7	-0.4	1.8	-0.8	0.6	-0.0	0.6
Commuting to job workplace: Car/motor vehicle	1.3	1.4	4.2	-1.6	1.2	0.4	-0.2	-1.4	-1.4	-1.1	0.2	-1.7	-1.6	0.6	2.0	1.3	-0.4	1.5	0.5	1.2	0.7
Commuting to job workplace: Public transport	1.3	1.5	4.5	0.7	0.0	1.2	1.7	0.8	1.4	2.1	1.3	1.4	2.0	0.7	-1.6	-0.3	1.8	-0.6	0.9	-0.2	0.6
Illnesses of father: High blood pressure	1.3	1.6	4.3	1.3	-0.5	-0.5	-1.4	0.2	0.1	-1.1	-1.6	-0.0	1.8	-1.9	-0.7	-1.6	-1.4	-1.2	-2.1	-1.5	-1.3
Diastolic blood pressure, automated reading	1.3	3.9	10.6	3.2	0.2	-0.8	-1.2	0.9	1.4	-0.4	-1.4	1.4	0.8	-3.0	-2.0	-3.0	-2.0	-2.1	-2.9	-2.9	-1.7
Supplements: Zinc	1.2	1.3	4.3	-0.2	1.1	0.9	1.3	0.5	0.7	1.4	1.7	-0.1	0.3	1.5	0.4	1.2	2.0	0.9	2.1	1.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.2	-0.0	1.8	0.7	1.5	-0.7	-0.5	0.4	1.0	-0.3	0.4	1.7	0.8	1.5	1.3	1.2	1.6	1.7	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	6.1	-2.5	-0.7	0.9	0.3	-1.9	-1.6	-1.2	0.3	-1.3	-1.3	1.1	1.6	1.6	-0.2	1.6	0.7	1.7	1.5
Birth weight of first child	1.2	2.3	6.2	-1.8	1.0	2.2	1.7	-1.7	-1.1	0.2	1.4	-0.4	1.1	1.6	0.9	1.6	1.1	1.5	1.2	2.0	2.5
Number of full sisters	1.2	1.4	5.0	0.3	-1.1	-2.2	-1.3	1.1	0.4	-0.3	-1.3	0.1	-0.8	-1.4	-0.6	-1.3	-1.1	-1.2	-1.1	-1.4	-2.0
Medication: Aspirin	1.2	1.6	7.5	1.6	2.7	0.5	1.3	1.5	1.5	1.8	1.2	1.3	0.9	0.6	-0.8	-0.2	1.5	-0.3	0.9	0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	14.3	2.4	3.8	0.7	1.6	2.3	1.7	1.7	0.9	1.9	1.3	0.1	-1.3	-0.6	1.6	-0.6	0.9	-0.2	-0.3
Myopia	1.2	1.7	4.7	-0.1	0.9	0.6	1.7	-0.7	0.0	1.1	1.6	-0.2	0.3	2.2	0.6	1.7	1.9	1.1	1.9	1.7	1.8
Coronary Artery Disease (CAD)	1.1	1.3	2.8	0.9	-1.1	-1.7	-0.9	0.8	0.6	-0.4	-1.3	0.8	-0.1	-1.4	-1.2	-1.5	-1.0	-1.5	-1.5	-1.5	-1.2
Ulcerative Colitis	1.1	1.6	5.9	1.0	-0.0	0.5	1.1	1.2	1.9	2.4	1.4	1.4	1.6	0.3	-1.8	-0.4	1.8	-0.8	0.9	-0.6	-0.2
Hypothyroidism (self reported)	1.1	2.5	7.0	-0.9	-1.3	-0.7	-1.7	-1.8	-2.5	-2.1	-1.2	-2.6	-1.5	0.3	2.5	1.0	-1.9	1.4	-0.6	0.9	0.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	4.2	-0.4	-0.2	2.1	1.9	-0.2	0.3	1.2	1.6	0.8	1.6	1.4	-0.2	0.8	1.4	0.7	1.3	1.2	1.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.7	0.2	0.2	0.8	1.5	1.4	1.8	1.9	1.4	1.9	1.5	0.3	-1.5	-0.3	1.8	-0.6	1.1	-0.3	-0.0
Illnesses of father: Heart disease	1.1	1.5	4.0	2.0	1.2	-0.8	0.1	1.8	2.0	0.5	-0.5	1.7	0.3	-1.0	-1.7	-1.3	0.5	-1.5	-0.6	-1.1	-1.0
Basal cell carcinoma (self-reported)	1.1	1.3	5.6	1.4	1.4	0.9	1.3	1.2	1.3	1.4	0.8	1.4	2.4	0.3	-1.0	-0.1	1.5	-0.3	0.7	0.1	0.4
Blood White Count	1.0	7.6	21.2	2.9	2.2	4.3	3.3	-0.1	2.2	2.7	4.2	1.3	4.6	2.3	-0.5	1.7	3.2	1.9	3.1	1.8	2.8
Cardiovascular Disease	1.0	3.3	8.2	2.7	2.5	1.8	1.8	2.2	2.2	1.3	0.5	2.9	2.8	-1.0	-2.0	-1.7	0.9	-1.4	-0.6	-0.8	-0.0
Relative age voice broke	1.0	1.5	4.9	0.6	0.0	0.7	1.4	1.8	1.8	2.2	1.1	1.8	1.0	0.5	-1.5	-0.5	1.5	-0.9	1.0	-0.4	-0.2
Happiness	1.0	1.2	3.6	0.3	0.5	1.4	1.4	1.5	1.5	1.4	1.3	1.2	1.3	0.6	-0.6	0.3	1.9	0.3	1.5	0.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.9	-1.1	-0.8	0.9	0.5	-1.3	-1.4	-0.6	0.5	-1.2	-0.6	1.2	1.7	1.4	0.2	1.5	0.9	1.6	1.3
Blood clot in the leg (DVT)	1.0	1.3	5.3	0.0	-1.2	-1.0	-1.9	-0.6	-0.6	-1.5	-1.3	-0.9	-2.3	-1.0	0.4	-0.4	-1.8	0.0	-1.2	-0.7	-0.8
Health satisfaction	1.0	1.2	3.0	0.7	1.1	1.2	1.4	1.3	1.6	1.5	1.3	1.3	1.4	0.6	-0.9	0.1	1.7	-0.0	1.2	0.3	0.2
Leg pain on walking	1.0	1.2	3.5	-0.5	-0.8	-1.1	-1.6	-0.7	-1.0	-1.7	-0.9	-1.6	-1.9	-0.8	1.3	0.2	-1.5	0.7	-0.4	-0.0	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	3.1	-1.8	-1.4	0.4	-0.4	-1.7	-1.2	-1.5	-0.4	-1.1	0.3	0.2	1.2	0.9	-0.7	1.1	-0.3	1.1	1.1
Long-standing illness, disability or infirmity	1.0	1.6	3.4	1.7	-0.3	0.2	0.2	1.4	1.7	0.8	0.0	1.7	1.6	-1.4	-1.8	-1.8	-0.1	-1.5	-1.1	-1.6	-0.8
Intelligence (Savage-Jansen 2018)	0.9	2.9	7.8	-1.5	1.0	1.6	2.5	0.4	0.3	2.2	2.1	0.3	-0.3	2.5	0.4	1.6	2.7	0.9	2.8	1.7	1.4
Height	0.9	18.2	78.1	-8.8	-5.6	-1.9	-3.5	-4.4	-6.2	-6.1	-4.7	-3.7	-4.8	-3.0	2.5	-0.1	-4.1	0.8	-4.1	-0.1	0.1
Loud music exposure frequency	0.9	1.0	4.2	-0.2	-0.4	1.3	1.0	-0.2	0.0	1.1	1.1	0.0	2.0	1.4	0.3	0.9	0.9	0.8	1.4	0.8	1.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.5	0.0	1.0	1.0	1.3	-0.1	0.9	1.4	1.5	0.4	1.5	1.2	-0.3	0.8	1.6	0.5	1.3	0.8	1.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	5.0	-1.1	-1.0	0.1	-0.7	-1.8	-2.0	-1.1	-0.1	-2.2	-1.0	1.1	2.2	1.5	-0.8	1.7	0.4	1.4	1.2
Medication: Ibuprofen	0.9	1.1	2.2	-1.1	-0.5	1.0	0.5	-1.3	-1.2	-0.5	0.7	-1.1	-0.2	1.1	1.5	1.3	0.2	1.4	0.9	1.4	1.2
Qualifications: nursing, teaching	0.9	1.4	4.3	-0.4	1.2	1.2	1.3	0.0	0.2	1.5	1.7	-0.1	0.0	1.9	0.3	1.4	1.7	0.8	2.1	1.2	0.9
Pain experienced in last month	0.9	1.5	4.6	0.8	1.4	-0.3	0.5	2.2	1.8	2.0	0.7	1.3	0.6	-0.2	-1.4	-0.9	1.3	-1.3	0.5	-1.1	-1.4
Prostate Cancer	0.8	1.2	2.8	1.5	1.6	0.7	1.6	1.0	1.2	1.7	1.0	1.3	0.3	0.8	-0.8	-0.1	1.5	-0.4	0.8	0.3	0.6
Systolic Blood Pressure	0.8	3.8	13.0	3.6	2.6	0.8	0.4	1.9	1.9	1.2	-0.0	2.5	2.3	-1.8	-2.5	-2.5	-0.3	-1.9	-1.4	-2.2	-1.0
Lung FVC	0.8	3.9	16.6	1.8	4.1	2.7	2.7	0.8	1.3	1.8	1.9	2.0	3.4	0.9	-1.2	0.2	2.2	-0.1	1.3	0.7	1.4
Medication: Levothyroxine sodium	0.8	1.4	3.5	-0.3	-1.0	-0.0	-0.9	-1.7	-1.8	-1.2	-0.2	-1.8	-1.1	0.7	1.9	1.2	-1.0	1.5	0.0	1.0	1.0
Medication: Lansoprazole	0.8	0.9	2.2	-0.5	0.4	0.7	-0.4	-1.4	-0.8	-0.6	0.7	-1.2	1.0	0.6	1.0	1.4	0.3	1.5	0.7	1.1	0.9
Neck or shoulder pain in last month	0.8	1.2	4.8	-0.7	0.3	0.9	0.2	-2.2	-1.4	-0.9	0.4	-0.9	0.4	0.9	0.9	1.3	-0.1	1.4	0.2	1.4	2.0
Medication: Seretide 50 evohaler	0.8	0.9	2.6	1.4	0.8	0.3	1.0	0.8	1.6	1.3	1.2	1.2	1.1	0.2	-1.1	-0.1	1.4	-0.3	0.9	-0.2	-0.1
Had major operations	0.8	1.0	2.4	-0.7	0.8	0.6	0.8	-0.3	-0.0	0.4	1.1	-0.5	-1.1	1.5	1.0	1.4	1.0	1.1	1.5	1.4	1.0
Number of self-reported non-cancer illnesses	0.8	1.4	4.1	0.2	-0.1	1.9	1.6	0.9	1.5	1.4	1.0	2.0	1.8	-0.1	-1.5	-1.0	0.6	-0.8	-0.0	-0.6	0.5
Fractured/broken bones in last 5 years	0.8	1.0	2.9	-0.2	-0.7	-0.5	-0.1	0.8	0.8	0.0	-1.0	1.3	1.7	-1.1	-1.5	-1.4	-0.4	-1.4	-1.2	-1.2	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.7	-0.1	-1.6	-0.8	-1.1	-0.7	-0.2	-1.4	-1.1	-0.0	1.4	-1.3	-0.1	-0.7	-1.4	-0.2	-1.5	-0.5	-0.1
Alzheimer’s Disease (in mother)	0.7	0.8	3.4	-1.1	-0.6	1.9	0.4	-1.4	-1.2	-0.6	0.4	-0.8	-0.1	0.3	1.1	0.6	-0.5	1.1	0.0	0.8	1.1
Triglycerides	0.7	1.2	3.5	-0.1	0.6	0.8	1.5	1.0	1.1	1.8	1.3	1.0	1.9	1.1	-0.7	0.3	1.7	-0.1	1.4	0.5	0.4
Smoking Status	0.7	1.6	6.7	1.6	2.2	1.8	1.6	0.8	1.1	1.1	1.0	1.7	2.6	0.1	-1.0	-0.4	0.9	-0.2	0.4	0.0	0.7
Relative age of first facial hair	0.7	1.5	4.2	0.1	0.1	0.2	1.8	1.9	1.7	1.8	0.7	2.0	1.4	0.1	-1.5	-0.9	1.5	-1.2	0.6	-0.5	-0.3
Severe depression (siblings)	0.7	0.8	3.4	-0.6	0.1	1.2	1.8	0.7	0.4	1.2	0.8	1.1	1.0	1.1	-0.0	0.1	0.8	0.1	0.9	0.7	1.0
Maternal smoking around birth	0.7	1.0	2.5	-0.6	-0.2	1.4	-0.3	-1.3	-1.1	-0.9	0.3	-1.3	1.0	0.6	1.4	1.2	-0.3	1.6	0.5	1.3	1.1
Taking other prescription medications	0.7	1.1	3.5	-1.1	-1.9	-0.3	-0.9	-0.4	-1.4	-1.5	-1.5	-0.3	-0.4	-1.2	0.4	-0.7	-1.7	-0.1	-1.5	-0.4	-0.2
Stomach or abdominal pain in last month	0.7	0.9	2.5	-0.2	-1.6	-0.2	-1.1	-0.9	-1.0	-1.5	-1.0	-0.9	-1.2	-0.7	0.7	-0.2	-1.5	0.2	-1.0	-0.2	-0.2
Supplements: Glucosamine	0.7	0.9	7.6	-1.4	-0.0	-0.7	-0.5	-0.0	-0.7	-1.3	-1.1	-0.6	-2.8	-0.1	1.0	0.5	-0.3	0.5	-0.1	0.7	-0.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.8	-0.3	-1.0	-1.1	-1.7	-0.3	-0.4	-1.2	-0.8	-1.2	-1.4	-0.9	0.6	-0.1	-1.1	0.2	-0.6	-0.4	-1.1
Medication: Atenolol	0.7	0.9	2.5	1.6	1.1	-0.9	-0.7	0.3	0.4	-0.7	-1.0	0.3	-0.0	-1.4	-0.4	-1.2	-1.2	-0.7	-1.5	-1.0	-0.8
Had other major operations	0.7	0.9	2.5	-0.7	0.3	0.1	0.3	-0.8	-0.9	-0.4	0.6	-0.8	-0.7	1.1	1.1	1.5	0.9	1.4	1.0	1.6	1.2
Time employed in main current job	0.7	0.8	2.4	-0.8	0.0	0.8	1.2	-0.8	-0.2	1.0	1.3	0.1	0.8	1.6	-0.0	0.9	0.9	0.5	1.1	0.8	1.4
Impedance of arm (left)	0.7	3.1	12.0	-3.1	-3.5	-0.6	-1.5	-2.0	-3.0	-1.8	-1.1	-2.4	-1.3	-0.2	1.7	0.7	-1.4	0.9	-0.7	0.4	0.2
Standing height	0.7	7.3	35.6	-6.0	-4.1	-1.6	-1.9	-1.8	-3.1	-3.6	-3.4	-1.3	-3.3	-2.5	0.7	-0.8	-2.5	-0.2	-2.9	-0.7	-0.5
Worry too long after embarrassment	0.7	1.2	6.5	-0.2	0.3	0.2	-0.8	-1.3	-1.0	-1.0	0.2	-1.8	-2.5	0.5	1.8	1.2	-0.5	1.4	0.4	0.9	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.3	0.8	-0.8	-1.0	-0.7	0.3	-0.2	-0.8	-1.5	0.3	-0.1	-1.1	-0.2	-1.2	-1.5	-0.6	-1.4	-0.9	-0.6
Age at last live birth	0.7	1.0	4.4	-0.1	0.3	0.9	2.1	0.8	0.3	1.3	1.0	1.3	-0.2	1.2	-0.5	0.3	1.4	-0.2	1.2	0.7	1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.5	0.7	-0.5	-0.6	0.4	1.1	1.1	1.6	0.3	1.3	0.5	-0.0	-1.6	-1.0	0.6	-1.5	-0.2	-1.1	-0.4
Loneliness, isolation	0.7	1.0	4.2	-0.7	-1.4	-0.6	-1.2	-0.9	-1.0	-1.4	-0.5	-1.5	-2.0	-0.1	1.3	0.6	-0.9	1.0	-0.1	0.4	-0.2
Ever taken oral contraceptive pill	0.7	0.7	2.4	0.8	1.6	0.5	1.2	0.4	1.1	1.5	1.0	0.8	-0.1	0.9	-0.7	0.1	1.0	-0.3	0.8	0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.1	-1.6	-1.2	-0.6	-1.2	-0.5	-1.0	-1.8	-1.2	-0.6	-0.7	-0.7	0.7	0.1	-1.2	0.4	-1.0	0.3	-0.1
Medication: Bendroflumethiazide	0.7	1.0	4.1	1.9	2.0	-0.5	-0.4	1.3	1.3	0.1	-0.4	1.1	-0.0	-1.0	-1.0	-1.0	-0.2	-0.7	-0.6	-0.9	-0.9
Alcohol drinker status: Never	0.7	0.8	2.7	0.9	-1.1	-0.2	0.1	1.6	1.5	1.4	0.7	1.0	-0.1	0.1	-1.1	-0.3	1.3	-0.6	0.7	-0.5	-0.8
Schizophrenia (2018)	0.6	1.2	3.0	-0.6	-0.6	-0.9	-1.4	0.3	-0.7	-1.2	-1.7	-0.2	-1.2	-1.4	0.1	-1.1	-1.6	-0.9	-1.6	-1.1	-1.4
Worry (Nagel 2018)	0.6	1.2	4.3	-1.6	-0.6	-0.3	-0.9	-1.1	-1.3	-1.3	-0.5	-1.5	-2.1	0.1	1.6	0.8	-0.8	1.1	-0.1	0.8	0.3
Alzheimer’s Disease (in father)	0.6	0.6	2.3	0.4	0.9	0.7	1.5	0.9	0.6	1.1	0.6	1.0	0.9	0.6	-0.3	0.1	1.2	0.0	0.9	0.4	0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	4.8	-0.1	0.3	2.2	1.6	-0.0	0.1	0.9	1.2	0.5	1.0	0.7	0.2	0.5	1.0	0.7	1.0	0.8	1.1
Breast Cancer	0.6	1.4	3.8	1.1	1.3	0.7	1.2	1.2	1.3	1.9	1.5	0.8	0.0	1.4	-0.4	0.7	1.9	0.3	1.9	0.5	0.2
Schizophrenia (2014)	0.6	1.4	3.0	-1.1	-0.9	-1.3	-1.6	0.0	-0.8	-1.4	-1.7	-0.9	-1.7	-1.2	0.4	-0.9	-1.5	-0.7	-1.4	-0.9	-1.4
Respiratory disease	0.6	1.2	3.9	-0.9	-0.9	0.0	0.9	2.0	1.2	1.1	-0.0	1.9	1.0	-0.8	-1.7	-1.1	1.1	-1.2	0.1	-0.8	-1.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.4	0.8	-1.1	-0.7	-1.4	0.4	0.4	-0.7	-1.1	0.0	-0.5	-1.4	-0.4	-1.3	-1.4	-0.9	-1.6	-1.4	-1.2
Medication: Ramipril	0.6	0.8	2.7	1.6	1.0	-0.8	-0.7	1.4	1.1	0.0	-0.5	0.8	-0.4	-1.0	-0.7	-1.0	-0.5	-0.7	-0.7	-0.9	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	4.2	1.4	0.5	0.4	0.7	1.1	1.5	0.7	0.3	1.5	2.1	-0.4	-1.2	-0.6	0.8	-0.6	-0.0	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	13.7	1.3	3.7	0.8	1.6	0.8	1.5	1.2	0.9	1.6	2.3	0.2	-1.2	-0.2	1.5	-0.4	0.5	0.1	0.6
Length of working week for main job	0.6	0.7	1.9	0.6	0.4	-0.7	-0.8	0.1	0.1	-0.3	-0.8	-0.2	-0.1	-1.3	-0.2	-1.1	-1.2	-0.7	-1.1	-1.4	-1.2
Forced vital capacity (FVC), Best measure	0.6	2.4	10.6	0.3	3.3	1.6	2.2	0.9	1.4	1.4	1.1	2.2	2.4	0.1	-1.6	-0.3	1.9	-0.5	0.6	0.1	1.0
Eye problems/disorders: None of the above	0.6	0.7	3.1	0.6	-0.8	-1.2	-1.2	-0.1	-0.3	-1.0	-0.8	-0.9	-1.8	-0.7	0.5	-0.2	-0.9	-0.1	-0.4	-0.5	-1.2
Medication: Allopurinol	0.6	0.8	3.1	0.9	0.7	0.2	0.6	1.3	1.8	1.1	0.6	1.6	0.2	-0.2	-1.4	-0.5	0.9	-0.6	0.3	-0.5	-0.2
Pulse rate, automated reading	0.6	1.8	5.5	2.3	1.2	-0.3	-0.0	1.5	1.4	1.0	-0.1	1.3	1.4	-1.5	-1.5	-1.9	-0.2	-1.5	-1.0	-1.8	-1.4
Medication for cholesterol	0.6	1.0	3.8	-1.9	-1.0	-0.6	-0.8	-0.8	-1.2	-0.3	0.0	-1.6	-2.0	0.4	1.1	0.9	0.1	0.7	0.6	0.4	-0.4
Breast cancer (self-reported)	0.6	0.7	1.8	-1.1	-0.1	0.9	0.7	-0.8	-0.9	0.2	0.8	-0.5	0.4	1.0	0.7	0.9	0.6	1.0	0.7	1.1	1.4
Osteoarthritis (self-reported)	0.6	0.8	3.8	-1.3	-1.9	1.1	-0.2	-1.4	-0.6	-0.9	-0.1	-0.4	1.0	-0.1	0.4	0.1	-0.9	0.4	-0.7	0.3	1.0
Mother’s age at death	0.6	0.7	2.4	0.0	1.2	0.3	1.5	0.8	0.9	1.4	0.9	1.1	-0.0	0.6	-0.7	-0.1	1.3	-0.4	0.8	0.2	0.3
Ever smoked	0.6	1.1	4.1	-0.6	0.7	2.0	0.7	-1.4	-1.2	-0.6	0.6	-0.6	1.2	0.7	1.1	1.0	0.1	1.2	0.4	1.3	1.6
Ever depressed for a whole week	0.6	0.8	3.0	-1.7	-0.4	0.2	0.4	0.2	-0.4	-0.2	0.3	-0.4	0.0	1.1	0.9	1.3	1.0	1.2	1.3	1.4	0.5
Pack years of smoking	0.6	0.9	3.2	0.2	0.2	0.4	-1.1	-1.8	-1.3	-1.2	-0.2	-1.5	-0.4	0.1	1.3	0.7	-1.2	1.1	-0.5	0.5	0.8
Impedance of whole body	0.6	3.3	11.6	-3.3	-2.4	-0.2	-1.1	-2.5	-3.4	-1.5	-0.6	-2.7	-0.8	0.6	2.1	1.5	-0.9	1.5	-0.0	1.1	0.8
Age at First Birth	0.5	0.7	2.1	0.0	0.6	0.8	1.0	0.3	1.3	1.5	1.3	0.7	-0.4	0.7	-0.8	0.3	1.4	-0.1	1.0	0.3	0.4
Bipolar Disorder (2011)	0.5	0.5	1.7	-0.6	-0.7	-0.5	-1.1	-0.3	-0.3	-0.7	-0.6	-0.8	-1.3	-0.8	0.3	-0.4	-0.9	-0.2	-0.6	-0.6	-1.0
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.2	-1.2	-0.5	-0.2	-0.9	-0.4	-1.1	-1.5	-1.1	-0.7	-1.0	-0.7	0.8	-0.0	-1.0	0.4	-0.8	0.2	-0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	-0.6	0.6	-0.2	-0.5	-0.9	-0.8	-0.9	-0.1	-1.0	0.7	0.6	1.1	1.0	-0.2	1.1	0.3	0.9	0.7
Systolic blood pressure, automated reading	0.5	1.4	3.6	1.9	0.4	1.0	-0.0	0.1	0.6	0.4	-0.1	1.2	1.8	-1.3	-1.5	-1.8	-1.0	-1.2	-1.7	-1.5	0.0
Impedance of leg (right)	0.5	2.6	10.0	-2.7	-0.8	0.4	-0.7	-2.3	-3.2	-1.2	-0.0	-2.5	-0.1	1.1	2.1	1.8	-0.5	1.8	0.5	1.5	1.2
Trunk fat percentage	0.5	2.0	7.2	-0.4	-2.6	0.7	-1.0	-1.8	-1.6	-2.0	-1.1	-0.8	0.2	-1.5	0.7	-0.9	-2.7	0.1	-2.1	-0.7	0.3
Fed-up feelings	0.5	0.8	2.1	-1.4	-0.7	0.7	-0.5	-1.3	-1.4	-1.4	-0.6	-0.9	-0.8	-0.3	1.0	0.2	-1.3	0.8	-0.7	0.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.0	1.0	0.0	-0.2	0.5	1.4	1.4	0.8	-0.0	1.4	0.2	-0.3	-1.2	-0.9	0.4	-0.9	-0.1	-0.6	-0.5
Qualifications: CSEs or equivalent	0.5	0.7	2.0	0.1	0.3	0.2	-0.8	-1.3	-1.4	-1.1	-0.1	-1.4	0.1	0.1	1.3	0.6	-1.2	1.1	-0.3	0.4	0.6
Sitting height	0.5	3.9	22.5	-4.7	-2.3	-0.9	-1.0	-1.8	-2.7	-2.7	-2.2	-1.4	-2.7	-1.1	1.3	0.2	-1.6	0.7	-1.4	0.3	0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	-0.0	1.3	0.7	1.1	0.2	0.2	0.5	0.7	0.4	-0.9	0.9	0.2	0.7	1.1	0.5	0.9	1.0	0.8
Impedance of leg (left)	0.5	2.5	9.7	-2.7	-0.8	0.2	-0.7	-2.2	-3.1	-1.1	-0.0	-2.4	0.1	0.9	2.0	1.7	-0.4	1.8	0.4	1.4	1.2
Trunk fat mass	0.5	2.2	7.8	-0.5	-2.5	0.4	-1.0	-1.2	-1.2	-2.1	-1.5	-0.3	-0.2	-2.1	0.2	-1.5	-2.8	-0.4	-2.6	-1.1	-0.2
Nervous feelings	0.5	0.9	5.2	-0.4	-2.3	-0.9	-1.0	0.2	-0.1	-0.9	-1.0	-0.2	-1.6	-0.9	0.1	-0.6	-1.1	-0.4	-0.8	-0.6	-0.9
Hearing difficulty/problems with background noise	0.5	0.8	3.1	0.3	0.2	0.2	0.8	0.1	0.6	0.8	1.1	-0.1	-0.1	1.8	0.6	1.2	1.1	0.8	1.5	1.4	0.9
Hair/balding pattern: Pattern 3	0.5	0.7	1.4	-0.5	1.2	1.1	1.1	-0.4	-0.5	0.6	1.0	-0.3	0.5	0.9	0.5	0.8	1.1	0.8	0.9	1.0	1.1
Number of live births	0.5	0.7	1.9	-0.1	-0.3	-0.2	-0.7	-1.2	-1.2	-1.2	-0.5	-1.3	-0.6	0.6	1.4	0.7	-1.0	0.8	-0.3	0.8	0.7
Asthma	0.5	1.0	3.5	-1.2	-0.8	-0.1	1.2	1.9	0.9	1.3	0.2	1.8	0.3	0.1	-1.0	-0.5	1.3	-0.7	0.7	-0.2	-0.4
Birth weight	0.5	1.1	3.2	-1.2	-0.2	-1.2	-1.5	-0.9	-1.3	-1.8	-1.6	-1.0	-0.2	-1.3	0.5	-0.3	-1.3	0.0	-1.4	-0.5	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.2	0.6	-0.2	-0.3	-1.3	-0.8	-0.3	-0.7	-0.7	-0.8	-0.7	-0.6	0.2	-0.5	-1.5	-0.2	-1.1	-0.7	-0.5
Supplements: Vitamin C	0.5	0.6	3.8	0.1	0.6	1.9	0.9	-0.8	0.2	0.5	1.2	0.1	1.1	0.5	0.1	0.4	0.4	0.4	0.4	0.5	1.0
Ever had bowel cancer screening	0.5	0.6	1.5	-0.5	-0.3	0.6	0.5	-0.8	-0.3	0.4	1.2	-0.8	-0.7	1.0	0.8	1.1	0.5	1.0	1.1	0.9	0.7
Medication: Atorvastatin	0.5	0.6	3.4	-0.4	-1.8	-0.7	-1.3	-0.4	-0.6	-1.0	-0.7	-0.6	-0.9	-0.7	0.3	-0.1	-1.0	-0.0	-0.8	-0.2	-0.5
Irritability	0.5	0.8	2.4	-1.5	-0.3	1.1	-0.2	-1.0	-1.4	-1.6	-0.4	-0.6	-0.5	-0.0	1.0	0.8	-0.4	1.1	-0.0	1.0	0.8
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.2	-0.9	0.5	0.4	1.4	0.6	0.4	1.4	1.0	0.5	-0.4	1.4	-0.1	0.8	1.8	0.2	1.6	0.9	0.7
HbA1C	0.4	0.4	1.4	-0.5	1.2	-0.1	0.4	0.8	-0.1	0.9	0.1	0.8	1.1	0.1	-1.1	-0.5	0.5	-0.8	0.1	-0.5	-0.2
Neuroticism (2016)	0.4	0.6	1.7	-0.5	-0.2	0.7	0.0	-1.2	-1.3	-1.1	0.0	-1.0	-0.2	0.2	1.3	0.5	-0.9	0.9	-0.3	0.8	0.8
Lung FEV1/FVC ratio	0.4	2.2	9.8	3.1	2.6	-0.6	-1.2	-1.2	0.5	-0.6	0.9	-2.1	-0.0	1.3	1.9	1.7	-0.4	1.8	0.9	1.1	0.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	-0.0	0.3	0.9	1.2	0.2	0.6	0.8	1.0	0.5	0.3	1.1	-0.0	0.7	1.1	0.5	1.3	0.8	0.7
Leg fat-free mass (left)	0.4	2.4	6.4	-0.4	-1.6	-0.8	-0.7	0.6	0.5	-1.3	-2.0	1.2	-1.0	-2.5	-1.2	-2.2	-1.8	-1.6	-2.5	-1.8	-1.2
Hand grip strength (right)	0.4	1.1	4.7	-0.8	0.6	0.1	-0.3	0.4	-0.1	-1.5	-1.6	1.0	0.3	-2.2	-0.7	-1.3	-1.0	-0.6	-1.7	-0.9	-0.6
Current tobacco smoking	0.4	0.6	2.7	0.7	1.2	1.6	0.8	-0.5	-0.6	-0.1	0.9	-0.2	0.8	0.5	0.7	0.6	0.1	1.0	0.6	0.9	0.9
Leg predicted mass (left)	0.4	2.4	6.4	-0.4	-1.7	-0.8	-0.8	0.6	0.5	-1.4	-2.1	1.1	-1.1	-2.5	-1.1	-2.2	-1.8	-1.6	-2.5	-1.8	-1.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.6	0.1	-1.2	-0.1	-1.3	-0.4	-0.3	-1.0	-0.5	-0.5	-0.1	-1.2	-0.2	-0.5	-1.0	-0.2	-0.8	-0.8	-1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	-1.0	0.3	0.5	0.7	0.5	0.3	0.2	0.3	0.2	0.0	0.9	0.4	0.8	1.0	0.8	1.0	1.1	0.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.5	0.1	-0.3	0.9	-0.3	-1.2	-0.7	-0.8	0.4	-1.2	-0.1	-0.1	1.1	0.6	-0.4	1.1	0.2	0.4	0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.6	-1.2	-1.6	-0.6	-0.7	-0.6	-0.7	-1.1	-0.7	-0.5	-0.7	-0.5	0.4	0.1	-0.6	0.2	-0.6	0.1	-0.1
Arm fat-free mass (right)	0.4	1.9	5.5	-0.7	-0.6	-0.9	-1.1	-0.1	-0.1	-2.0	-2.1	0.5	-1.2	-2.3	-0.5	-1.5	-2.0	-0.9	-2.3	-1.2	-0.9
Wheeze or whistling in the chest in last year	0.4	0.7	3.1	0.5	-0.2	0.3	1.2	0.9	1.2	0.8	0.3	1.8	1.6	-0.3	-1.0	-0.8	0.4	-0.6	-0.0	-0.3	0.2
Medication: Omeprazole	0.4	0.5	3.2	0.1	-0.9	-0.2	-0.5	-0.4	0.2	-0.9	-0.7	0.3	1.8	-1.0	-0.3	-0.6	-0.9	-0.2	-1.1	-0.4	0.1
Whole body fat mass	0.4	1.7	6.5	-0.1	-2.0	0.5	-0.8	-1.0	-0.9	-1.9	-1.4	-0.1	0.0	-1.9	0.1	-1.4	-2.5	-0.4	-2.4	-1.0	-0.1
Whole body fat-free mass	0.4	2.3	6.2	-0.7	-1.2	-1.0	-0.8	0.5	0.4	-1.5	-2.2	1.1	-1.3	-2.5	-1.1	-2.0	-1.7	-1.5	-2.5	-1.7	-1.2
Leg fat-free mass (right)	0.4	2.3	6.0	-0.2	-1.5	-0.9	-0.6	0.8	0.8	-1.1	-1.9	1.3	-0.9	-2.4	-1.4	-2.2	-1.5	-1.7	-2.4	-1.8	-1.2
Back pain experienced in last month	0.4	0.6	1.4	0.3	-0.7	-0.6	-0.2	0.7	0.4	-0.1	-1.0	0.9	0.3	-1.0	-1.0	-1.1	-0.3	-1.2	-1.0	-0.9	-0.8
Asthma (self-reported)	0.4	0.8	2.9	-1.3	-0.7	-0.1	1.1	1.7	0.9	1.2	0.2	1.7	0.4	-0.0	-1.0	-0.5	1.2	-0.7	0.6	-0.2	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	-1.2	-1.2	-0.1	-0.3	-1.3	-1.0	-0.2	0.3	-1.1	0.4	0.5	0.8	0.6	-0.7	0.7	0.2	0.3	0.4
Whole body water mass	0.4	2.2	6.1	-0.6	-1.1	-1.0	-0.8	0.6	0.5	-1.5	-2.1	1.2	-1.3	-2.5	-1.1	-2.0	-1.7	-1.5	-2.4	-1.6	-1.2
Leg predicted mass (right)	0.4	2.4	6.2	-0.3	-1.5	-0.9	-0.6	0.8	0.8	-1.1	-2.0	1.4	-0.9	-2.5	-1.4	-2.3	-1.6	-1.7	-2.4	-1.9	-1.3
Miserableness	0.4	0.7	3.6	-1.9	-1.4	0.4	-0.2	-1.2	-0.7	-0.3	0.2	-0.6	-0.4	0.7	0.6	0.9	-0.0	0.8	0.3	0.8	0.9
Financial situation satisfaction	0.4	0.6	1.5	0.3	0.9	1.2	1.2	0.4	0.7	0.5	0.7	0.6	1.1	0.6	0.1	0.3	0.9	0.4	0.7	0.8	0.8
Basal metabolic rate	0.4	2.2	6.4	-0.5	-1.3	-0.8	-0.7	0.4	0.4	-1.5	-2.1	1.1	-1.0	-2.5	-1.1	-2.1	-1.9	-1.4	-2.5	-1.7	-1.1
Heart disease (siblings)	0.4	0.5	1.3	-0.1	0.7	0.9	0.5	-1.0	-0.8	-0.5	0.4	-0.4	0.1	0.5	0.5	0.8	0.5	0.8	0.3	1.0	1.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.5	-0.6	0.0	-0.4	-0.9	0.4	-0.4	-0.7	-1.0	-0.2	-1.2	-1.1	-0.0	-1.0	-1.2	-0.8	-1.1	-1.2	-1.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	-1.0	-1.0	-0.3	-0.5	-0.6	-0.9	-0.8	-0.5	-0.7	-1.1	0.2	0.7	0.4	-0.4	0.4	-0.1	0.4	0.3
Hand grip strength (left)	0.3	0.7	3.9	-0.5	2.0	1.1	0.6	0.6	0.5	-0.6	-0.5	1.3	0.9	-1.4	-0.9	-0.8	0.1	-0.4	-0.8	-0.4	-0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.6	0.2	-0.1	-0.4	0.4	0.6	-0.5	-0.8	0.7	0.7	-0.6	-0.4	-0.6	-0.8	-0.3	-0.8	-0.4	-0.1
Angina	0.3	0.4	1.8	1.3	0.6	-0.3	-0.4	0.3	0.5	0.1	-0.2	0.5	0.6	-0.6	-0.8	-0.7	-0.2	-0.6	-0.7	-0.8	-0.4
Diabetes (mother)	0.3	0.4	1.0	0.6	0.9	0.6	0.5	-0.5	-0.1	0.1	0.5	-0.1	1.0	0.7	0.5	0.7	0.3	0.7	0.6	0.8	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.3	-0.2	0.2	-0.7	-0.9	-0.6	-0.8	-0.7	-0.7	-0.7	-1.1	-0.1	0.4	0.1	-0.7	0.0	-0.5	-0.0	-0.1
Serious illness, injury or assault to yourself	0.3	0.3	1.0	0.7	0.7	0.6	0.6	0.9	0.8	0.7	0.3	0.7	1.0	0.1	-0.6	-0.3	0.6	-0.3	0.3	-0.1	-0.1
Multivitamins +/- minerals	0.3	0.3	1.1	-0.2	-0.4	-0.6	-0.8	-0.1	-0.4	-1.0	-0.6	-0.6	-0.9	-0.4	0.7	0.2	-0.7	0.5	-0.3	0.2	-0.4
Body mass index (BMI)	0.3	1.2	6.9	2.6	0.6	0.9	0.5	0.6	1.4	0.1	0.1	1.3	1.2	-1.0	-0.9	-1.4	-0.9	-0.8	-1.0	-1.0	-0.2
Past tobacco smoking	0.3	0.5	4.2	-0.3	-1.4	-1.1	-0.7	0.0	-0.2	-0.1	-0.4	-0.5	-2.0	-0.1	0.1	-0.0	-0.3	-0.1	-0.1	-0.3	-0.5
Heart attack	0.3	0.3	1.2	0.6	1.1	0.0	-0.4	0.5	0.7	0.2	0.7	-0.3	0.5	0.2	0.2	0.7	0.8	0.8	0.8	0.4	-0.2
Diabetes (self-reported)	0.3	0.5	1.8	1.4	0.4	0.2	0.3	0.6	1.1	0.9	0.3	0.9	0.3	-0.2	-1.0	-0.8	0.2	-0.8	-0.4	-0.7	-0.0
Illnesses of siblings	0.3	0.5	2.0	-1.4	-1.4	-1.0	0.2	0.3	-0.7	0.1	-0.2	-0.2	-0.8	0.9	0.5	0.5	0.2	0.1	0.6	0.6	0.1
Weight	0.3	1.5	5.0	-0.0	-1.2	0.1	-0.3	-0.0	0.1	-1.3	-1.4	0.9	-0.2	-2.1	-0.7	-1.8	-1.9	-1.0	-2.2	-1.4	-0.5
Impedance of arm (right)	0.3	1.4	8.5	-2.5	-2.9	-0.2	-0.5	-1.1	-2.0	-0.6	-0.4	-1.3	-0.7	0.3	0.9	0.5	-0.4	0.5	-0.1	0.3	0.3
Arm fat percentage (right)	0.3	1.1	3.2	1.8	-1.1	0.8	-0.0	0.0	0.5	-0.4	-0.3	0.8	1.0	-1.4	-0.7	-1.7	-1.6	-0.8	-1.6	-1.3	-0.3
Trunk fat-free mass	0.3	2.0	5.4	-0.9	-0.9	-1.1	-0.7	0.6	0.4	-1.5	-2.1	1.2	-1.5	-2.3	-1.1	-1.8	-1.5	-1.4	-2.2	-1.5	-1.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	7.4	1.1	2.7	0.6	1.0	0.3	1.0	0.4	0.4	1.1	2.0	-0.4	-1.0	-0.4	0.8	-0.4	-0.1	-0.2	0.4
Pulse rate	0.3	0.5	2.0	0.6	0.7	-0.0	0.3	1.4	0.7	0.7	0.4	0.6	1.3	-0.5	-0.5	-0.3	1.1	-0.3	0.5	-0.5	-1.1
Medication: Cholesterol lowering	0.3	0.5	2.4	0.8	1.0	0.8	0.5	-0.3	0.7	0.3	0.6	1.0	1.6	-0.2	-0.8	-0.2	0.4	-0.2	-0.4	-0.0	0.9
Lung cancer (father)	0.3	0.4	1.9	-0.5	1.2	1.4	0.5	-0.5	-0.5	0.3	0.7	-0.3	0.2	0.6	0.6	0.4	-0.2	0.5	0.4	0.4	0.7
Arm fat mass (right)	0.3	1.2	4.1	1.0	-1.2	0.5	-0.3	-0.3	0.1	-1.2	-0.9	0.5	0.4	-1.8	-0.4	-1.6	-2.0	-0.7	-2.0	-1.2	-0.3
Trunk predicted mass	0.3	1.9	5.2	-0.8	-0.9	-1.0	-0.6	0.6	0.4	-1.4	-2.0	1.2	-1.4	-2.3	-1.1	-1.8	-1.4	-1.4	-2.2	-1.4	-1.1
Body fat percentage	0.3	1.3	5.8	0.4	-1.9	0.7	-0.7	-1.1	-1.0	-1.6	-0.9	-0.3	0.4	-1.4	0.4	-1.1	-2.4	-0.1	-1.9	-0.8	0.1
Pulse wave peak to peak time	0.3	0.3	1.0	-0.6	0.0	-0.8	0.3	0.8	0.4	0.5	-0.5	1.0	-0.0	0.1	-0.9	-0.4	0.3	-0.9	-0.2	-0.2	-0.1
Leg fat mass (right)	0.3	1.0	4.3	0.6	-0.7	1.0	-0.2	-0.7	-0.4	-1.3	-0.8	0.2	0.5	-1.5	0.1	-1.2	-2.1	-0.3	-1.9	-0.7	0.1
Arm predicted mass (right)	0.3	1.7	5.1	-0.6	-0.6	-0.9	-1.0	0.0	0.0	-1.8	-2.0	0.6	-1.0	-2.3	-0.6	-1.5	-1.8	-1.0	-2.2	-1.3	-0.9
Arm fat percentage (left)	0.3	1.3	3.7	1.8	-1.1	0.6	-0.4	-0.1	0.4	-0.8	-0.6	0.6	1.0	-1.7	-0.5	-1.7	-1.9	-0.8	-1.9	-1.3	-0.4
Eye problems/disorders: Cataract	0.3	0.3	2.3	-1.5	-0.3	0.7	0.7	-0.3	-0.6	-0.1	-0.1	0.2	0.4	0.3	0.3	0.2	0.2	0.2	-0.1	0.6	0.8
Mineral and other dietary supplements	0.3	0.4	2.0	1.4	0.9	0.2	0.7	0.1	0.2	1.2	0.8	0.2	0.7	0.6	-0.3	-0.1	0.4	-0.3	0.5	-0.2	0.2
Arm fat mass (left)	0.3	1.2	4.0	1.0	-1.1	0.6	-0.3	-0.4	0.2	-1.2	-0.9	0.6	0.5	-1.8	-0.4	-1.6	-2.0	-0.7	-2.0	-1.2	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.6	0.0	-0.7	-0.2	-1.1	0.7	0.2	-0.3	-0.6	-0.2	-0.1	-0.8	-0.1	-0.6	-0.7	-0.4	-0.6	-0.8	-1.3
High cholesterol (Self-reported)	0.3	0.5	1.9	0.4	-0.9	0.4	0.2	-0.3	0.3	-0.1	0.0	1.0	1.4	-0.5	-1.1	-0.6	-0.1	-0.7	-1.0	-0.4	0.7
Arm fat-free mass (left)	0.3	1.3	4.0	-0.5	-0.5	-0.5	-0.3	0.2	0.4	-1.2	-1.6	1.1	-0.6	-2.0	-1.0	-1.6	-1.4	-1.1	-2.0	-1.2	-0.6
Unable to work because of sickness or disability	0.3	0.3	1.3	-0.3	-0.5	-0.1	-0.5	-0.1	-0.6	-1.1	-0.9	-0.1	0.3	-0.7	0.5	-0.3	-1.1	0.3	-0.6	-0.1	-0.3
Supplements: Calcium	0.3	0.4	2.3	-1.0	-1.5	-0.6	-0.9	-0.0	-0.0	0.1	-0.2	-0.5	-1.1	-0.1	0.1	0.0	-0.2	-0.1	0.0	-0.4	-0.7
Leg fat mass (left)	0.3	1.0	4.4	0.6	-0.9	0.9	-0.3	-0.7	-0.4	-1.4	-0.8	0.2	0.6	-1.5	0.0	-1.3	-2.1	-0.3	-1.9	-0.8	0.1
Ovarian Cancer	0.2	0.3	1.4	0.8	1.2	-0.2	-0.6	-0.2	-0.6	-0.5	-0.1	-1.0	0.2	0.0	0.9	0.5	-0.1	0.6	0.2	0.4	-0.3
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.1	-0.4	0.5	0.4	0.6	0.7	0.8	0.6	0.4	0.6	0.3	-0.2	0.1	0.7	0.0	0.7	-0.1	-0.1
Primary Biliary Cirrhosis	0.2	0.3	1.2	0.2	-0.4	-0.5	-0.5	0.3	0.1	0.1	-0.7	0.1	-1.1	-0.3	-0.5	-0.6	-0.3	-0.8	-0.6	-0.6	-0.6
Waist Hip Ratio (WHR)	0.2	1.0	7.5	1.8	2.7	-0.4	-1.1	0.0	-0.0	-1.1	-0.6	-0.6	-0.1	-1.0	0.3	-0.5	-1.2	-0.1	-1.0	-0.5	-0.7
Chronotype (morning person)	0.2	0.6	2.3	1.5	0.7	-0.6	-1.1	-0.0	-0.5	-0.8	-0.3	-0.9	-1.5	-0.2	0.7	0.4	-0.5	0.8	0.1	0.1	-0.5
Average weekly spirits intake	0.2	0.3	1.4	0.7	0.7	0.3	0.6	0.5	0.8	0.5	-0.2	1.2	0.2	0.0	-0.7	-0.4	0.4	-0.5	-0.2	0.1	0.4
Vitamin and mineral supplements	0.2	0.3	0.8	-0.1	0.5	0.1	0.7	-0.1	-0.1	0.8	0.7	0.0	0.3	0.9	-0.1	0.5	0.9	0.2	0.9	0.5	0.5
Pack years adult smoking proportion	0.2	0.4	1.1	1.0	0.6	0.6	-0.6	-1.0	-0.6	-0.5	0.1	-0.8	0.1	0.1	0.7	0.4	-0.7	0.7	-0.2	0.2	0.6
Townsend deprivation index at recruitment	0.2	0.2	0.6	0.4	-0.0	0.6	0.0	0.3	0.2	0.1	-0.4	0.5	0.6	-0.4	-0.4	-0.8	-0.7	-0.5	-0.6	-0.6	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.1	-0.6	0.3	-0.3	-0.2	-0.5	-0.6	-0.4	-0.3	-0.5	-1.1	0.5	0.7	0.4	-0.2	0.2	-0.1	0.5	0.5
Waist circumference	0.2	0.6	3.2	1.4	0.2	1.8	1.0	-0.3	0.7	0.1	0.8	0.7	1.3	-0.3	-0.3	-0.6	-0.4	0.1	-0.4	-0.1	0.8
Forced vital capacity (FVC)	0.2	0.9	4.6	0.4	2.1	0.9	1.1	0.3	0.7	0.2	0.2	1.5	1.6	-0.8	-1.4	-0.7	0.7	-0.6	-0.5	-0.4	0.4
Financial difficulties in last 2 years	0.2	0.3	1.2	-0.0	0.5	0.9	0.2	-0.0	-0.4	-0.2	0.6	-0.7	0.2	0.2	1.1	0.6	0.1	1.1	0.7	0.5	0.0
Medication: Simvastatin	0.2	0.3	0.9	0.5	0.7	0.3	0.2	-0.4	0.4	-0.0	0.2	0.8	0.8	-0.6	-0.9	-0.7	-0.3	-0.5	-1.0	-0.5	0.6
Hip circumference	0.2	0.8	5.8	-0.2	-2.4	1.7	1.1	-0.4	0.4	0.2	0.7	0.9	1.2	-0.4	-0.5	-0.6	-0.4	-0.1	-0.4	-0.2	0.8
Exposure to tobacco smoke at home	0.2	0.3	0.8	0.5	0.9	0.1	0.3	-0.7	-0.3	-0.1	0.4	-0.5	-0.7	0.4	0.6	0.6	0.1	0.7	0.3	0.7	0.7
Tense / ‘highly strung’	0.2	0.3	1.1	-1.0	-0.5	-0.6	-0.3	-0.2	-0.6	-0.8	-0.5	-0.5	-1.0	-0.0	0.9	0.3	-0.5	0.6	0.1	0.4	-0.1
Peak expiratory flow (PEF)	0.2	0.4	3.6	0.7	1.3	0.5	0.3	-0.3	0.8	-0.1	0.2	0.5	1.9	-0.2	-0.5	0.0	0.3	-0.0	-0.1	0.0	0.5
Pulse wave reflection index	0.2	0.3	2.2	1.5	1.4	0.2	0.2	0.1	0.7	0.0	0.3	-0.0	-0.5	-0.1	0.1	-0.0	0.1	0.1	0.2	-0.0	-0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.2	-1.0	-0.3	0.1	0.3	-0.6	-0.8	0.2	0.2	-0.7	-0.7	1.1	0.7	0.6	0.0	0.3	0.7	0.6	0.5
Leg fat percentage (right)	0.2	0.6	2.1	1.3	-0.1	1.4	0.3	-0.6	-0.3	-0.6	0.0	0.2	1.2	-0.6	0.2	-0.8	-1.5	0.1	-1.0	-0.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.0	-0.2	0.4	0.0	0.5	0.7	1.0	0.3	0.4	1.0	-0.2	-0.2	-0.8	-0.2	0.6	-0.3	0.3	-0.1	-0.2
Number of children fathered	0.2	0.2	1.2	0.1	1.1	-0.0	0.1	-0.6	-0.1	-0.0	0.7	-0.4	-0.1	0.5	0.5	0.7	0.2	0.6	0.5	0.5	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	0.4	-0.0	-0.2	-0.7	0.8	0.7	-0.2	-0.6	0.2	-0.5	-0.8	-0.3	-0.6	-0.1	-0.4	-0.6	-0.5	-0.8
Emphysema/chronic bronchitis	0.2	0.3	0.8	0.2	0.1	-0.6	-0.6	-0.7	-0.8	-0.9	-0.7	-0.5	-0.5	-0.3	0.3	0.0	-0.6	0.1	-0.6	0.0	0.0
Angina (self-reported)	0.2	0.3	1.4	1.2	0.7	-0.1	-0.2	0.1	0.3	0.1	-0.1	0.4	0.7	-0.5	-0.6	-0.6	-0.1	-0.5	-0.6	-0.6	-0.2
Illnesses of siblings: Diabetes	0.2	0.3	2.2	0.7	0.3	0.6	0.1	-0.0	0.8	0.6	0.9	-0.1	1.5	0.0	-0.2	0.1	0.6	0.2	0.3	-0.1	0.1
Smoking status: Previous	0.2	0.3	2.8	0.0	0.6	0.5	0.6	0.3	0.7	0.4	0.3	0.6	1.7	0.1	-0.3	-0.2	0.4	-0.2	0.1	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	-0.9	-0.6	-0.4	0.2	0.8	0.5	0.5	-0.5	0.7	0.4	-0.4	-0.9	-0.7	0.1	-0.9	-0.4	-0.7	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.8	-0.6	-1.4	0.2	-0.7	-1.0	-0.1	-0.8	-0.0	-0.6	-0.2	-0.1	0.1	0.5	-0.3	0.4	-0.1	0.2	0.1
Diabetes diagnosed by doctor	0.2	0.4	1.1	0.7	-0.3	0.2	-0.1	0.3	0.7	0.3	-0.2	0.7	0.2	-0.6	-0.8	-1.0	-0.5	-0.9	-0.9	-0.8	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	-0.4	-0.7	-0.8	-0.7	0.2	0.1	-0.5	-0.5	-0.2	0.5	-0.5	0.0	-0.1	-0.3	-0.1	-0.2	-0.3	-0.7
Medication: Gliclazide	0.2	0.2	0.7	-0.6	-0.5	0.6	-0.0	-0.8	-0.6	-0.3	0.4	-0.5	-0.1	0.1	0.5	0.3	-0.3	0.4	-0.1	0.2	0.6
Smoking status: Current	0.2	0.3	1.9	0.9	1.4	1.0	0.1	-0.4	-0.5	-0.6	0.3	-0.3	0.5	-0.2	0.4	0.2	-0.3	0.7	-0.0	0.3	0.4
Average weekly champagne plus white wine intake	0.2	0.2	0.6	-0.3	0.8	0.2	0.5	-0.1	0.2	0.8	0.6	0.1	-0.4	0.8	-0.0	0.4	0.6	0.1	0.6	0.3	0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.8	-0.0	-0.5	0.3	-0.8	-0.9	-0.5	-0.4	-0.1	-0.8	-0.2	0.2	0.3	0.5	-0.3	0.4	-0.2	0.2	0.3
Leg fat percentage (left)	0.2	0.6	2.0	1.2	-0.2	1.3	0.3	-0.6	-0.3	-0.5	0.1	0.2	1.3	-0.6	0.2	-0.7	-1.4	0.1	-1.0	-0.3	0.6
Average weekly beer plus cider intake	0.2	0.3	3.1	0.3	-1.8	-0.2	-0.6	-0.3	0.2	-0.4	-0.3	-0.0	0.4	-0.6	-0.5	-0.4	-0.3	-0.4	-0.7	-0.4	-0.2
Risk taking	0.2	0.3	1.9	0.7	0.6	-1.4	-0.7	0.5	0.8	0.2	-0.3	-0.2	-0.7	-0.0	-0.1	-0.1	-0.2	-0.3	0.1	-0.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.2	0.7	1.1	-0.2	-0.5	0.5	0.8	0.1	0.5	-0.2	0.4	0.0	0.0	0.5	0.6	0.6	0.6	0.2	-0.4
Arm predicted mass (left)	0.2	1.0	2.9	-0.7	-0.7	-0.4	-0.2	0.1	0.2	-1.1	-1.4	1.0	-0.7	-1.7	-0.8	-1.4	-1.2	-0.9	-1.7	-1.0	-0.4
Bipolar Disorder (2018)	0.1	0.1	0.6	-0.2	0.8	0.5	0.2	0.2	0.2	0.5	0.5	0.0	-0.4	-0.0	-0.1	-0.2	0.1	-0.1	0.3	-0.4	-0.3
Depression (Nagel 2018)	0.1	0.2	0.5	0.5	0.7	0.6	0.1	0.1	0.5	0.2	0.6	0.1	-0.5	0.4	0.1	0.4	0.4	0.5	0.6	0.4	0.1
Heel T-Score	0.1	1.1	7.2	2.7	2.2	-0.1	0.0	0.9	1.7	0.9	0.8	0.5	0.0	0.6	-0.4	0.3	0.6	0.0	0.8	0.1	-0.2
BMI	0.1	0.7	5.4	2.3	0.2	1.2	-0.5	-0.0	0.9	-0.7	0.2	0.0	0.4	-0.9	0.2	-0.7	-1.4	0.1	-0.7	-0.6	-0.4
Hair Pigment	0.1	2.6	9.5	1.5	3.1	0.5	2.0	1.9	1.8	1.9	0.9	2.3	2.4	0.0	-1.9	-0.9	1.6	-1.1	0.5	-0.6	-0.0
Tanning	0.1	1.0	4.9	-0.0	2.2	0.5	0.4	-1.2	-0.5	0.1	0.7	-0.7	-0.1	1.4	0.8	1.2	0.2	1.1	0.8	1.2	1.4
Number of treatments/medications taken	0.1	0.3	0.8	0.2	-0.1	0.7	-0.0	-0.8	-0.4	-0.8	-0.2	0.1	0.4	-0.5	0.1	-0.3	-0.9	0.2	-0.9	0.0	0.8
Diabetes (father)	0.1	0.1	0.3	0.4	0.2	-0.1	0.4	0.2	0.1	0.4	0.2	0.0	-0.2	0.6	0.1	0.2	0.3	0.0	0.3	0.4	0.4
Age when periods started (menarche)	0.1	0.2	0.8	-0.9	-0.9	0.3	0.3	0.9	0.4	0.2	-0.1	0.8	-0.3	-0.3	-0.5	-0.2	0.5	-0.2	0.2	-0.1	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.0	-0.7	-1.0	0.1	-0.2	0.2	-0.0	-0.5	-0.2	-0.2	-0.1	-0.8	0.2	-0.3	-0.4	0.0	-0.3	-0.3	-0.7
Father’s age at death	0.1	0.1	0.5	0.3	-0.3	-0.3	0.3	0.6	0.7	0.1	0.0	0.6	-0.2	-0.2	-0.4	-0.1	0.5	-0.2	0.3	-0.0	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.7	0.3	0.8	0.4	0.3	0.5	0.5	0.2	-0.2	0.7	-0.6	-0.2	-0.5	-0.6	-0.3	-0.5	-0.3	-0.4	-0.2
Glaucoma (self-reported)	0.1	0.2	0.7	-0.2	-0.1	0.8	0.0	-0.6	-0.4	-0.0	0.3	-0.4	0.0	0.5	0.3	0.6	0.2	0.4	0.3	0.5	0.5
Overall health rating	0.1	0.2	1.3	1.1	0.2	1.0	0.2	-0.4	0.4	0.3	0.8	0.1	0.8	0.1	-0.2	-0.0	-0.0	0.2	0.0	-0.0	0.4
Age started oral contraceptive pill	0.1	0.2	1.4	-0.5	0.0	-0.2	-0.0	0.1	-0.5	-0.3	-0.2	-0.1	-1.2	0.3	0.4	0.3	-0.0	0.3	0.1	0.4	0.2
Cholesterol lowering medication	0.1	0.1	0.3	-0.1	-0.6	-0.0	-0.2	-0.5	-0.4	-0.5	0.1	-0.3	-0.5	0.1	0.2	0.1	-0.4	0.2	-0.3	0.2	0.5

Hub : Genes

CCDC18

Models

Trait associations