Best TWAS P=1.42e-11 · Best GWAS P=2.53e-07 conditioned to 0.303
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-326C3.11 | 0.40 | 0.17 | lasso | 7 | 0.17 | 1.1e-13 | 4.37 | 5.2 | 2.5e-07 | -0.77 | 0.08 | 0.88 | FALSE |
2 | GTEx | Brain Hypothalamus | RP11-326C3.12 | 0.39 | 0.26 | lasso | 4 | 0.26 | 7.7e-07 | -5.16 | -5.3 | 1.4e-07 | 0.96 | 0.00 | 0.98 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | RP11-326C3.7 | 0.34 | 0.08 | enet | 25 | 0.15 | 1.7e-05 | -4.62 | -5.1 | 2.8e-07 | 0.43 | 0.02 | 0.70 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | B4GALNT4 | 0.11 | 0.01 | lasso | 4 | 0.01 | 4.8e-02 | 2.59 | 5.4 | 5.3e-08 | -0.04 | 0.04 | 0.15 | TRUE |
5 | GTEx | Skin Sun Exposed Lower leg | RP11-326C3.11 | 0.33 | 0.08 | lasso | 6 | 0.07 | 1.4e-06 | -5.16 | 5.6 | 1.8e-08 | -0.96 | 0.00 | 0.99 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | RP11-326C3.12 | 0.09 | 0.02 | enet | 9 | 0.05 | 7.1e-05 | -4.62 | -5.6 | 1.8e-08 | 0.71 | 0.01 | 0.97 | FALSE |
7 | GTEx | Whole Blood | IFITM3 | 0.09 | 0.02 | enet | 12 | 0.07 | 5.2e-07 | 4.22 | 6.2 | 8.0e-10 | -0.43 | 0.10 | 0.50 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIRT3 | 0.04 | 0.01 | blup | 76 | 0.03 | 2.0e-06 | 0.29 | 5.2 | 1.5e-07 | 0.08 | 0.02 | 0.77 | TRUE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | IFITM3 | 0.10 | 0.03 | blup | 57 | 0.02 | 1.8e-02 | 1.93 | 5.4 | 6.4e-08 | -0.70 | 0.00 | 0.59 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IFITM3 | 0.04 | 0.02 | blup | 57 | 0.02 | 4.7e-03 | -4.62 | 6.8 | 1.4e-11 | -0.69 | 0.01 | 0.28 | TRUE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IFITM3 | 0.06 | 0.01 | blup | 57 | 0.03 | 1.2e-04 | 4.37 | 5.4 | 6.5e-08 | -0.56 | 0.04 | 0.79 | FALSE |