Best TWAS P=1.09e-18 · Best GWAS P=1.91e-24 conditioned to 3.06e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | C11orf21 | 0.18 | 0.10 | enet | 10 | 0.10 | 1.3e-06 | -10.2 | -8.8 | 1.1e-18 | 0.88 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Heart Left Ventricle | C11orf21 | 0.18 | 0.02 | lasso | 4 | 0.04 | 2.6e-03 | -10.2 | -7.8 | 4.3e-15 | 0.89 | 0.00 | 0.99 | FALSE |
| 3 | GTEx | Spleen | TSPAN32 | 0.57 | 0.02 | enet | 4 | 0.13 | 3.4e-04 | -7.5 | -6.9 | 5.1e-12 | 0.81 | 0.05 | 0.33 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CD81 | 0.10 | 0.00 | blup | 30 | 0.03 | 5.2e-03 | -4.9 | -5.6 | 2.2e-08 | 0.44 | 0.01 | 0.25 | FALSE |
| 4 | YFS | Blood | ASCL2 | 0.28 | 0.07 | bslmm | 438 | 0.27 | 2.1e-87 | 1.7 | -5.5 | 5.1e-08 | 0.59 | 0.18 | 0.82 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSPAN32 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.5e-05 | 4.5 | -5.4 | 8.3e-08 | 0.44 | 0.97 | 0.01 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C11orf21 | 0.05 | 0.07 | lasso | 3 | 0.07 | 3.6e-08 | -5.6 | -5.2 | 2.0e-07 | 0.66 | 0.82 | 0.17 | FALSE |