Hub : Genes

SIRT3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.3090 0.0620 1.2e-13 0.156 NA 0.178 NA 0.189 9.3e-13 NA 1.7e-14 NA 2.4e-15
2 GTEx Adipose Visceral Omentum 0.1930 0.0590 3.3e-04 0.114 NA 0.096 NA 0.088 1.6e-06 NA 1.1e-05 NA 2.6e-05
3 GTEx Artery Aorta 0.1430 0.0420 4.8e-05 0.079 NA 0.128 NA 0.130 3.9e-05 NA 1.6e-07 NA 1.3e-07
4 GTEx Artery Tibial 0.1942 0.0432 1.6e-10 0.170 NA 0.170 NA 0.169 2.6e-13 NA 2.7e-13 NA 3.2e-13
5 GTEx Brain Nucleus accumbens basal ganglia 0.3110 0.0910 3.3e-04 0.179 NA 0.141 NA 0.153 1.6e-05 NA 1.3e-04 NA 6.9e-05
6 GTEx Cells Transformed fibroblasts 0.2080 0.0480 4.0e-09 0.133 NA 0.145 NA 0.150 3.9e-10 NA 5.6e-11 NA 2.2e-11
7 GTEx Colon Transverse 0.2460 0.0590 1.3e-07 0.248 NA 0.254 NA 0.283 4.1e-12 NA 2.0e-12 NA 6.8e-14
8 GTEx Esophagus Gastroesophageal Junction 0.3230 0.0690 1.0e-06 0.117 NA 0.218 NA 0.225 5.2e-05 NA 2.1e-08 NA 1.2e-08
9 GTEx Esophagus Mucosa 0.1350 0.0450 3.5e-04 0.056 NA 0.028 NA 0.057 1.2e-04 NA 5.3e-03 NA 1.1e-04
10 GTEx Esophagus Muscularis 0.4410 0.0550 5.6e-17 0.364 NA 0.361 NA 0.385 3.7e-23 NA 6.8e-23 NA 1.1e-24
11 GTEx Heart Atrial Appendage 0.3040 0.0630 2.3e-07 0.296 NA 0.259 NA 0.275 8.9e-14 NA 5.0e-12 NA 9.5e-13
12 GTEx Heart Left Ventricle 0.1933 0.0550 5.7e-05 0.194 NA 0.165 NA 0.175 1.4e-10 NA 3.8e-09 NA 1.3e-09
13 GTEx Lung 0.1927 0.0586 3.0e-05 0.059 NA 0.059 NA 0.077 2.5e-05 NA 2.5e-05 NA 1.6e-06
14 GTEx Nerve Tibial 0.2130 0.0494 3.2e-08 0.140 NA 0.139 NA 0.156 3.8e-10 NA 5.0e-10 NA 3.6e-11
15 GTEx Thyroid 0.0780 0.0340 2.8e-03 0.062 NA 0.035 NA 0.051 1.7e-05 NA 1.1e-03 NA 8.5e-05
16 METSIM Adipose 0.1166 0.0304 5.6e-10 0.096 0.089 0.095 0.098 0.101 3.1e-14 3.0e-13 4.2e-14 1.9e-14 6.7e-15
17 ROSMAP Brain Pre-frontal Cortex 0.0987 0.0274 1.8e-06 0.087 0.049 0.078 0.057 0.078 2.7e-11 5.9e-07 3.1e-10 7.6e-08 2.6e-10
18 TCGA Breast Invasive Carcinoma 0.0390 0.0155 8.2e-05 0.012 0.027 0.019 NA 0.018 1.4e-03 2.0e-06 6.7e-05 NA 1.2e-04
19 TCGA Head and Neck Squamous Cell Carcinoma 0.0630 0.0258 2.1e-04 0.021 0.032 0.016 NA 0.020 1.6e-03 1.4e-04 5.1e-03 NA 2.5e-03
20 TCGA Brain Lower Grade Glioma 0.0445 0.0260 6.9e-03 0.019 0.016 0.009 NA 0.008 2.6e-03 5.0e-03 2.8e-02 NA 4.1e-02
21 TCGA Prostate Adenocarcinoma 0.0421 0.0214 7.3e-03 0.003 0.008 0.000 NA 0.002 1.4e-01 4.8e-02 3.2e-01 NA 2.1e-01
22 TCGA Thyroid Carcinoma 0.0690 0.0490 2.8e-03 0.003 0.024 0.028 NA 0.021 1.4e-01 2.0e-03 8.2e-04 NA 3.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bipolar Disorder (2018) 1.1 1.7 6.0 -1.3 -0.6 -0.9 -0.9 -1.0 -1.2 -0.9 0.1 -1.2 0.9 1.1 1.1 -1.6 -1.3 -1.3 -1.5 -0.8 -2.3 -0.3 -2.4 -2.0 -1.4
Bipolar Disorder or Schizophrenia 0.3 0.8 3.2 -0.5 -0.8 -0.1 -0.3 -1.3 -0.6 -0.2 0.8 -0.7 0.9 1.0 1.1 -0.7 -0.9 1.1 -0.6 -0.6 -1.8 -0.9 -1.0 -1.6 -0.9
Depressed Affect (Nagel 2018) 0.6 1.3 7.8 1.4 1.2 1.1 1.1 -0.5 1.4 1.3 0.8 1.4 0.1 -0.1 -0.1 1.7 1.5 2.8 1.1 -0.1 -0.1 1.0 -0.1 0.7 1.3
Depression (Nagel 2018) 0.6 0.8 2.8 0.7 -0.5 1.0 0.6 -1.5 0.6 0.6 1.4 0.3 1.2 1.1 1.1 0.6 0.5 1.5 0.2 -0.1 -1.7 -0.1 -0.3 -1.1 0.2
Intelligence (Savage-Jansen 2018) 0.2 0.7 2.5 1.0 1.1 1.0 0.9 -0.6 1.2 0.8 0.4 0.7 0.2 -0.0 -0.1 1.2 1.4 1.6 0.5 0.9 0.3 -0.8 0.6 0.5 -0.4
Neuroticism (Nagel 2018) 0.5 1.1 4.0 1.4 1.1 1.2 1.3 -0.4 1.5 1.4 1.0 1.4 0.4 0.1 0.1 1.7 1.4 2.0 1.0 -0.4 -0.7 0.5 -0.2 0.1 0.5
Schizophrenia (2018) 0.3 0.6 6.3 0.4 -0.6 0.6 0.5 -1.0 0.2 0.4 1.0 0.1 0.5 0.4 0.4 0.4 -0.0 2.5 0.3 -0.1 -0.5 -0.9 0.6 -0.4 -0.3
Schizophrenia vs Biploar Disorder 0.1 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.6 0.5 0.4 -0.1
Worry (Nagel 2018) 0.0 0.1 0.5 0.1 0.2 0.1 0.3 -0.1 0.2 0.0 0.4 0.0 0.3 0.3 0.2 0.2 0.1 0.4 0.1 -0.1 -0.6 0.1 -0.2 -0.7 0.2
Alzheimer’s Disease (in mother) 1.3 1.5 6.4 -1.1 -1.4 -0.9 -1.1 1.2 -1.4 -1.6 -1.7 -1.5 -1.3 -1.0 -1.0 -0.7 -0.7 1.2 -1.1 2.5 0.1 -0.5 0.1 -0.7 -1.8
Alzheimer’s Disease (in father) 0.6 0.6 1.8 -0.6 -0.5 -0.4 -0.4 -0.6 -0.6 -0.2 0.8 -0.6 0.9 0.9 0.9 -1.3 -0.9 -0.2 -0.7 -1.3 -0.8 0.2 -0.9 -0.9 -0.8
Alzheimer’s Disease (including proxy) 0.4 0.5 2.1 -0.6 -0.8 -0.4 -0.5 0.8 -0.9 -1.0 -0.8 -0.8 -0.8 -0.6 -0.6 -0.6 -0.5 1.1 -0.7 1.1 0.2 0.1 -0.1 -0.2 -1.4
Crohns Disease (2017) 0.1 0.2 0.9 -0.1 -0.0 -0.6 -0.2 0.9 -0.2 -0.2 -0.3 -0.0 -0.3 -0.2 -0.1 -0.1 -0.6 0.9 -0.1 -0.5 -0.2 0.1 -0.8 -0.2 -0.5
Irritable Bowel Disease (IBD) 0.1 0.3 1.8 0.0 0.2 -0.5 0.2 1.4 -0.1 0.0 -0.9 0.3 -0.9 -0.9 -0.8 0.2 -0.1 0.3 0.3 -0.4 0.0 0.8 -0.2 0.2 0.0
Ulcerative Colitis (UC) 0.2 0.4 1.3 -0.4 -0.1 -0.6 -0.0 1.0 -0.4 -0.4 -1.2 -0.1 -1.1 -1.1 -1.0 -0.1 -0.0 -0.7 -0.1 0.3 -0.0 0.8 -0.1 -0.0 0.1
Major Depression (MDD) 0.1 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.6 1.0 0.1 -0.6
Reaction Time 0.8 1.5 3.2 1.5 1.3 1.7 1.6 -0.1 1.6 1.6 0.1 1.5 -0.3 -0.6 -0.5 1.2 1.8 1.8 1.3 -0.2 0.7 -0.1 1.4 1.6 0.8
Verbal and Numeric Reasoning (VNR) 0.1 0.2 1.1 -0.1 0.5 -0.2 -0.3 -0.4 0.1 -0.4 -0.1 -0.3 0.0 -0.0 -0.1 0.3 0.2 0.2 -0.6 1.0 -0.3 -1.0 -0.6 -0.5 -0.8
Breast Cancer 0.2 0.6 6.1 -0.3 -0.5 -0.8 -0.5 -0.1 -0.6 0.2 0.5 0.0 0.3 0.3 0.4 -0.6 -0.7 1.0 -0.1 -2.5 -0.8 1.3 -0.8 -0.3 0.0
Ovarian Cancer 0.6 0.9 2.0 -0.9 -1.4 -1.3 -1.0 -0.1 -1.2 -0.7 -0.5 -0.7 -0.3 -0.0 -0.0 -1.4 -1.2 0.5 -0.5 -1.3 -1.1 1.2 -1.1 -1.1 -0.4
Prostate Cancer 1.3 1.9 4.7 1.3 2.1 1.0 1.0 1.3 1.2 1.2 -0.6 1.3 -1.1 -1.3 -1.3 1.5 2.2 1.4 1.7 0.6 1.0 0.4 1.6 1.4 1.9
Age at First Birth 3.6 5.2 11.6 -2.9 -2.7 -3.2 -3.0 0.7 -2.8 -2.9 -1.7 -2.8 -0.9 -0.3 -0.4 -2.9 -2.1 -1.4 -2.6 1.4 -1.5 0.8 -2.5 -2.5 -3.4
Bipolar Disorder (2011) 0.4 0.4 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.4 0.1 -2.0 -1.7 0.0
Body Mass Index (BMI) (2010) 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.4 -0.1 -0.1 0.0 0.8
Coronary Artery Disease (CAD) 0.1 0.1 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.1 1.1 -0.5 -0.2 -0.6
Crohns Disease (2012) 0.8 1.4 5.1 -0.7 0.7 -1.9 -1.1 2.2 -0.8 -1.2 -2.3 -0.2 -1.9 -1.6 -1.6 -0.4 0.0 0.1 -0.1 0.9 0.7 1.2 -0.6 0.1 -0.8
Mean Putamen Volume 0.2 0.2 0.8 0.2 -0.6 0.3 0.2 -0.5 0.2 0.2 0.9 -0.0 0.7 0.6 0.6 -0.1 -0.3 0.7 -0.1 -0.5 -0.4 -0.1 -0.5 -0.4 0.1
Fasting Glucose 1.4 1.7 7.2 1.4 0.5 1.2 1.6 -1.2 1.4 1.8 1.9 1.5 1.5 1.2 1.1 0.9 0.3 1.7 1.0 -2.7 -0.1 -0.7 0.4 0.4 0.4
HbA1C 3.6 4.0 14.6 1.8 1.2 0.2 1.0 1.6 1.7 1.9 -0.9 2.7 -1.7 -2.2 -2.3 1.3 1.3 1.1 2.7 -2.6 2.5 3.8 0.8 1.3 3.1
HDL Cholesterol 0.1 0.1 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.4 0.1 -0.4 0.3
LDL Cholesterol 0.1 0.1 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.2 0.4 -0.8 -0.7 -1.4
Lupus 1.0 1.6 18.4 -0.5 -0.8 -0.2 -0.0 -1.5 -0.9 -0.3 0.8 -0.9 1.1 1.2 1.4 -1.0 -1.2 4.3 -0.9 -0.6 0.2 -1.3 -0.1 -0.1 -0.7
Neuroticism (2016) 0.4 0.6 1.7 -0.2 0.4 -1.0 -0.9 1.2 -0.0 -0.1 -0.7 0.2 -1.3 -1.3 -1.2 -0.1 0.5 -0.5 0.1 0.2 0.9 1.3 0.2 0.6 -0.3
Primary Biliary Cirrhosis 1.2 1.7 13.1 1.0 0.6 0.3 0.2 1.5 0.8 0.6 -1.4 1.1 -1.7 -1.8 -1.8 0.9 1.2 3.6 1.3 0.9 0.7 0.8 0.9 1.0 -0.3
Rheumatoid Arthritis 1.8 2.4 6.2 2.2 2.4 2.0 1.9 0.1 2.0 2.5 0.9 2.3 0.1 -0.2 -0.2 1.4 1.6 1.9 1.9 -1.7 0.4 -0.0 1.1 1.3 0.7
Schizophrenia (2014) 0.3 0.7 1.9 -0.5 -1.2 -0.0 -0.1 -1.3 -0.5 -0.4 0.8 -0.8 0.8 0.9 0.8 -0.5 -0.7 0.5 -0.7 0.3 -1.2 -1.3 -0.3 -1.4 -1.0
Triglycerides 0.1 0.1 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 -1.3 0.3 0.3 -0.2
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 -0.2 -0.0 0.2 -0.9
Ulcerative Colitis 0.3 0.5 2.3 -0.8 0.3 -1.0 -0.5 0.8 -0.9 -0.6 -0.9 -0.6 -0.6 -0.4 -0.4 -0.9 -0.5 -1.5 -0.5 0.1 -0.2 0.5 -0.6 -0.7 -0.2
Blood Eosinophil Count 0.1 0.9 5.6 0.2 0.7 0.1 -0.1 -2.2 0.3 0.0 0.7 0.1 0.2 -0.0 0.7 -0.2 -0.9 2.0 -0.3 -0.1 2.4 -1.0 0.7 1.4 -0.2
Blood Platelet Count 41.2 477.4 1036.8 25.0 24.4 25.1 22.2 14.2 26.1 19.0 -3.2 22.4 -12.7 -16.5 -16.6 30.5 32.2 16.7 23.4 23.9 21.4 -7.0 27.6 27.7 17.1
Blood Red Count 0.4 4.1 27.6 1.5 2.1 2.3 1.6 -0.4 2.3 1.8 1.4 1.6 0.8 0.3 0.5 1.1 1.6 -0.2 1.0 0.2 5.2 -0.9 2.7 3.8 2.6
Blood White Count 0.2 1.7 6.5 1.2 1.7 0.8 0.6 -0.1 1.1 1.6 0.1 1.9 0.0 -0.1 0.9 1.1 1.2 0.5 1.4 -2.5 2.1 0.3 1.6 2.4 0.2
Heel T-Score 0.5 3.8 7.5 -2.5 -2.1 -2.6 -2.4 0.1 -2.6 -2.1 -0.4 -2.3 0.7 1.1 1.1 -2.7 -2.7 -2.5 -2.4 -1.5 -0.8 1.3 -2.4 -1.7 -0.6
BMI 1.2 7.1 19.8 2.5 0.3 3.5 3.0 -4.0 2.4 3.4 4.5 2.0 3.9 3.4 3.5 1.6 0.8 2.4 1.4 -3.7 -1.4 -1.7 1.3 0.0 1.2
Height 0.4 7.1 37.8 -3.1 -0.8 -2.6 -2.5 1.7 -2.6 -4.1 -3.1 -3.6 -2.1 -1.7 -1.6 -2.6 -1.5 2.1 -3.4 6.2 1.4 -1.3 -1.8 -1.4 -1.7
Waist Hip Ratio (WHR) 0.4 1.7 4.9 -1.4 -2.2 -0.9 -2.0 0.0 -1.5 -1.6 -0.7 -1.7 -0.3 0.1 0.1 -1.0 -1.1 2.0 -1.6 1.5 -0.3 -0.0 -1.1 -1.2 -1.7
Systolic Blood Pressure 0.0 0.1 0.3 -0.1 -0.1 -0.1 -0.6 -0.3 0.1 -0.1 0.2 -0.0 -0.1 -0.2 -0.3 0.1 -0.1 0.2 0.0 0.3 0.4 0.1 0.2 -0.1 -0.6
Smoking Status 0.4 0.9 4.1 0.6 1.1 1.6 0.7 -1.3 1.0 0.7 1.3 0.4 1.2 1.1 1.0 0.5 1.0 -0.9 0.2 0.6 0.1 -2.0 0.5 0.3 -0.4
Allergy or Eczema 1.2 3.1 7.1 -2.3 -2.7 -2.0 -1.7 0.4 -2.3 -2.5 -0.5 -2.5 -0.1 0.4 0.6 -1.2 -2.0 2.2 -2.3 1.8 -1.1 -1.4 -1.0 -1.6 -2.1
Cardiovascular Disease 0.5 1.8 6.4 1.5 0.7 1.6 1.6 -1.2 1.5 1.6 1.6 1.3 0.5 0.2 0.2 1.7 1.3 2.5 1.4 -0.2 1.0 -1.1 1.7 1.1 0.9
Hypothyroidism (self reported) 0.8 1.9 8.9 2.0 1.1 1.9 1.6 -1.5 1.5 1.7 0.9 1.5 0.6 0.3 0.3 1.8 1.3 3.0 1.5 -0.1 -0.8 -0.5 1.2 1.1 0.7
Respiratory disease 0.3 0.6 3.4 0.1 -0.5 0.7 0.4 -1.2 -0.2 0.1 0.6 -0.4 0.8 0.9 1.0 -0.0 -0.5 -1.7 -0.4 0.3 -1.0 -1.8 0.3 -0.3 -0.6
Type 2 Diabetes (T2D) (2018) 1.0 1.9 7.4 1.9 0.6 2.7 1.8 -1.1 1.7 2.1 2.1 1.3 1.5 1.1 1.2 1.2 1.2 0.7 1.1 -0.6 -0.5 -1.1 0.8 0.7 0.9
Lung FEV1/FVC ratio 0.3 1.6 6.2 -0.5 -0.1 -0.8 -0.6 1.8 -0.0 -0.9 -1.6 -0.2 -1.8 -1.8 -2.1 0.6 0.4 0.3 0.1 2.5 2.3 0.8 0.9 1.5 0.2
Lung FVC 0.2 0.9 1.9 -0.9 -0.9 -0.7 -0.6 -0.7 -1.1 -0.8 0.6 -1.1 0.9 1.0 1.2 -1.1 -1.2 0.1 -1.2 -0.9 -0.9 -0.9 -0.5 -1.0 -1.4
Neuroticism 0.4 1.0 4.1 1.2 0.7 1.2 0.9 -1.2 1.3 1.2 1.8 1.0 1.1 0.8 0.8 0.9 0.8 2.0 0.6 -0.7 -0.1 -0.1 0.7 0.5 0.3
Chronotype (morning person) 0.2 0.4 1.3 0.8 0.1 0.8 0.9 0.2 0.4 0.7 -0.3 0.6 -0.4 -0.5 -0.6 0.9 0.4 0.1 0.9 -0.4 0.4 1.0 1.1 0.7 0.7
Hair Pigment 0.1 2.3 6.6 1.7 0.8 2.1 2.1 -1.9 1.7 1.8 2.6 1.2 1.9 1.5 1.4 1.3 0.6 1.7 1.1 -1.4 -0.2 -1.3 1.3 0.4 0.9
Tanning 0.1 1.2 3.1 -1.4 -1.1 -1.0 -1.2 -0.8 -1.4 -1.0 -0.1 -1.2 0.6 0.8 0.9 -1.6 -1.5 -0.9 -1.2 -0.6 -1.1 0.3 -1.8 -0.9 -1.0
Hand grip strength (left) 0.1 0.1 0.7 -0.2 0.0 -0.2 -0.3 0.4 -0.3 -0.2 -0.1 -0.2 -0.0 -0.0 0.0 -0.9 -0.4 0.6 0.1 -0.5 0.6 0.1 0.4 -0.0 0.6
Number of treatments/medications taken 0.7 1.3 4.7 1.4 0.8 1.1 1.7 -0.6 1.2 1.4 0.8 1.4 0.3 0.1 0.1 1.2 1.2 2.2 1.5 -1.0 0.7 -0.4 1.4 1.1 1.4
Average weekly spirits intake 0.2 0.3 2.4 -0.1 -1.2 0.3 0.0 -0.6 -0.1 0.1 0.4 -0.2 0.5 0.5 0.6 -0.1 -0.2 1.5 -0.0 -0.3 -0.1 0.3 -0.1 -0.4 0.7
Sensitivity / hurt feelings 0.2 0.3 1.0 -0.3 0.2 0.0 -0.1 -0.8 -0.1 -0.3 0.3 -0.4 0.5 0.6 0.6 -0.5 -0.2 0.8 -0.9 0.5 -0.8 -0.9 -1.0 -0.5 -0.9
Frequency of depressed mood in last 2 weeks 0.1 0.2 1.3 -0.1 -0.2 -0.1 -0.2 -0.3 -0.2 -0.2 0.2 -0.2 0.1 0.1 0.1 -0.3 0.0 1.1 0.0 0.3 -1.1 0.4 -0.2 -1.0 -0.2
Hearing difficulty/problems: Yes 1.5 2.3 5.0 -1.6 -1.3 -2.1 -2.2 0.7 -1.7 -2.0 -1.7 -1.5 -1.0 -0.7 -0.8 -1.6 -1.6 1.3 -1.7 1.0 -0.3 1.4 -2.0 -0.8 -2.1
Relative age of first facial hair 2.4 5.0 16.0 -1.5 0.5 -2.5 -1.9 3.9 -1.4 -2.1 -4.0 -0.8 -3.9 -3.6 -3.6 0.0 -0.0 0.3 -0.4 3.0 2.0 2.3 -0.2 0.6 -0.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.2 0.7 0.1 0.5 0.7 0.1 0.7 0.5 0.4 0.6 -0.1 -0.2 -0.2 0.6 0.8 0.5 0.8 0.1 -0.2 0.6 1.1 0.4 1.1
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.9 1.2 0.5 0.5 0.8 -0.1 0.9 1.1 0.4 1.2 -0.2 -0.3 -0.4 0.9 1.0 1.7 1.0 -1.1 0.6 0.5 0.7 1.0 -0.1
Ever had hysterectomy (womb removed) 1.6 1.8 4.9 -1.5 -0.8 -1.6 -1.6 1.7 -1.5 -1.9 -1.6 -1.3 -1.5 -1.1 -1.2 -0.7 -0.7 1.0 -1.2 1.9 2.2 0.3 0.3 0.7 -1.1
Systolic blood pressure, automated reading 0.1 0.2 1.6 -0.0 0.1 -0.1 -0.3 0.2 0.1 -0.2 -0.1 -0.0 -0.4 -0.4 -0.5 0.3 0.3 1.2 0.1 1.1 -0.1 0.1 -0.1 -0.6 -0.2
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 1.2 0.1 0.2 -0.0 0.0 0.2 0.1 -0.1 -0.5 -0.0 -0.7 -0.8 -0.7 0.4 0.5 -0.0 0.0 1.1 -0.2 0.4 -0.7 0.2 -0.0
Angina 0.6 0.8 2.2 1.2 1.0 1.1 1.3 -0.7 1.1 1.4 0.9 1.2 0.6 0.4 0.4 0.5 0.7 0.6 1.0 -1.5 -0.1 0.0 0.7 0.4 0.4
Medication for hormone replacement therapy 3.2 3.6 7.9 -2.5 -2.3 -2.3 -2.1 -0.7 -2.6 -2.7 -0.7 -2.8 0.4 0.9 0.8 -2.0 -2.1 0.4 -2.7 1.4 -1.7 -1.0 -2.2 -2.2 -1.4
Vitamin and mineral supplements 0.4 0.5 1.6 0.7 0.6 1.2 1.1 -0.8 0.8 1.0 1.2 0.4 0.9 0.7 0.5 0.6 0.3 -0.9 0.3 -0.3 -0.1 -0.1 -0.5 -0.1 1.0
Supplements: Zinc 0.3 0.4 1.1 -0.8 -0.2 -1.1 -0.8 0.5 -0.6 -0.9 -0.7 -0.5 -0.7 -0.5 -0.5 -0.7 -0.2 -0.1 -0.5 1.0 -0.0 -0.1 -0.3 -0.1 -0.7
Medication: Co-codamol 0.7 0.8 2.8 1.1 0.1 0.9 1.1 0.4 1.0 1.1 1.1 1.0 0.2 0.1 0.0 1.2 1.1 1.7 1.1 -0.6 -1.0 0.4 0.3 0.1 0.5
Medication: Metformin 1.2 1.6 5.7 1.6 1.1 2.4 1.9 -1.0 1.5 1.8 1.7 1.0 1.2 0.9 0.9 1.4 1.1 0.7 1.0 0.0 -0.3 -1.4 1.0 0.7 1.3
Diabetes (father) 3.5 4.4 8.8 -2.7 -1.9 -2.4 -2.6 -0.2 -2.4 -2.9 -1.2 -2.7 0.3 0.8 0.8 -2.0 -2.1 -2.3 -3.0 1.7 -2.0 -0.0 -2.9 -1.9 -2.7
Diabetes (mother) 3.8 4.9 11.5 3.4 2.2 3.3 3.2 -0.4 3.0 3.1 1.6 2.9 0.2 -0.3 -0.3 3.2 2.7 0.8 2.7 -0.7 0.8 -0.6 2.2 2.0 1.9
Severe depression (siblings) 1.4 1.6 3.2 -1.6 -1.7 -1.5 -1.6 0.7 -1.8 -1.7 -1.2 -1.7 -0.6 -0.2 -0.3 -1.4 -1.3 -0.5 -1.4 1.4 -0.9 0.2 -0.9 -1.3 -1.6
Pack years adult smoking proportion 1.3 2.0 5.3 1.9 1.0 2.1 2.1 -1.0 1.9 2.3 1.6 1.8 1.1 0.7 0.7 1.5 0.8 -0.3 1.6 -2.0 0.1 -0.3 1.2 0.6 1.4
Impedance of leg (right) 0.8 4.0 14.6 -0.2 -0.2 -1.3 -1.0 3.1 -0.2 -1.1 -3.5 0.2 -3.8 -3.6 -3.7 0.8 1.1 0.6 0.3 2.8 1.7 2.2 -0.1 1.2 -1.2
Leg fat-free mass (left) 0.6 3.4 11.1 -0.3 -1.0 1.0 0.6 -3.2 -0.2 0.2 2.7 -1.0 3.3 3.2 3.3 -1.3 -1.5 0.8 -1.1 -0.9 -1.9 -2.3 -0.5 -2.1 0.5
Trunk fat percentage 0.6 2.3 9.4 1.2 -0.7 2.0 1.6 -2.4 1.0 1.5 2.5 0.6 1.9 1.7 1.8 1.3 0.6 3.1 0.3 -0.8 -0.9 -1.8 0.5 -0.2 -0.0
Hand grip strength (right) 0.0 0.1 0.4 0.0 0.1 0.2 -0.2 0.3 -0.1 -0.0 -0.1 -0.2 0.1 0.1 0.1 -0.6 -0.2 0.4 0.1 0.0 0.7 -0.2 0.3 0.3 0.5
Townsend deprivation index at recruitment 2.2 3.1 9.7 1.4 -0.7 2.5 2.0 -2.6 1.6 1.6 3.1 0.9 2.9 2.6 2.6 0.6 0.8 -0.3 0.5 -0.4 -0.6 -3.0 1.1 -0.2 -0.5
Current tobacco smoking 0.7 1.2 4.3 0.2 -0.5 1.3 0.7 -1.7 0.7 0.3 1.9 -0.1 1.9 1.7 1.7 -0.1 0.2 -1.2 -0.5 0.4 -0.6 -2.1 0.2 -0.4 -0.5
Average weekly fortified wine intake 1.2 1.4 5.1 -0.2 -0.3 -1.0 -0.8 1.8 -0.4 -0.7 -1.9 0.1 -2.2 -2.1 -2.0 0.0 0.2 0.3 0.4 1.1 1.2 1.8 0.7 0.6 0.7
Maternal smoking around birth 0.9 1.3 4.6 0.9 0.1 1.0 1.0 -0.6 1.0 1.0 2.1 0.9 1.5 1.2 1.3 0.5 0.2 0.9 0.7 -1.8 1.3 -0.3 1.0 0.7 1.8
Fed-up feelings 0.3 0.5 3.3 0.4 0.1 0.2 0.1 -1.0 0.4 0.7 1.3 0.5 0.8 0.7 0.8 -0.1 0.0 1.8 0.2 -1.2 -0.2 0.6 -0.1 0.2 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 2.8 0.7 -0.3 0.6 0.2 -0.7 0.4 0.7 0.7 0.5 0.5 0.4 0.5 0.3 0.3 1.4 0.5 -0.4 -1.7 0.4 -0.1 -1.2 -0.1
Relative age voice broke 2.4 3.7 10.6 -1.8 0.3 -2.6 -2.0 2.7 -1.7 -2.4 -3.3 -1.3 -3.1 -2.8 -2.8 -0.9 -0.6 -0.5 -0.9 2.7 1.7 0.9 -0.1 0.2 -1.1
Taking other prescription medications 1.1 1.7 6.4 1.6 1.3 1.2 1.5 0.5 1.6 1.4 0.5 1.6 -0.5 -0.8 -0.6 1.8 1.8 2.5 1.8 -0.1 0.3 0.7 1.2 0.9 1.5
Age when periods started (menarche) 3.3 8.0 19.9 -3.6 -2.7 -4.0 -4.5 2.5 -3.4 -3.9 -3.6 -2.9 -2.4 -1.7 -1.8 -3.1 -2.6 -2.1 -2.7 2.0 -0.1 2.6 -2.9 -1.9 -1.9
Bilateral oophorectomy (both ovaries removed) 2.1 2.4 18.5 -1.1 0.3 -1.4 -1.1 1.8 -0.8 -1.6 -1.5 -0.8 -1.5 -1.4 -1.4 -0.3 -0.4 1.4 -1.3 2.2 4.3 -0.5 0.4 2.0 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.0 11.2 -1.2 -2.6 -0.2 -0.5 -2.5 -1.2 -0.8 2.2 -1.7 3.0 3.2 3.3 -1.6 -2.0 -0.1 -2.0 -1.0 -2.0 -2.5 -1.1 -2.5 -1.7
Tinnitus: Yes, but not now, but have in the past 1.5 1.7 4.0 1.9 0.7 1.2 1.6 0.6 1.7 1.7 0.2 2.0 -0.7 -1.0 -0.9 1.4 1.6 1.5 2.0 -0.8 0.5 1.0 1.3 0.8 0.6
Qualifications: CSEs or equivalent 0.8 1.0 3.1 -1.1 -1.0 -1.1 -1.4 -0.7 -0.9 -1.0 0.2 -1.0 0.8 0.9 1.0 -1.3 -1.8 -1.7 -1.1 -0.2 -0.6 0.5 -0.9 -1.1 -0.4
Serious illness, injury or assault to yourself 0.3 0.4 3.1 0.3 -0.0 -0.1 0.3 -0.0 0.6 0.3 0.3 0.5 0.2 -0.0 0.1 0.3 -0.0 -0.6 0.2 -1.1 1.8 1.0 0.4 1.0 0.8
High blood pressure 1.0 2.9 8.7 1.8 1.9 2.2 2.1 -0.3 1.9 1.6 1.1 1.5 0.0 -0.3 -0.4 2.4 2.2 3.0 1.7 1.1 1.5 -1.6 1.9 1.8 1.8
Hayfever, allergic rhinitis or eczema 1.3 2.8 9.0 -2.2 -3.0 -2.0 -1.7 -0.3 -2.3 -2.1 -0.1 -2.2 0.5 0.9 1.0 -1.5 -2.4 0.6 -2.1 0.2 -1.2 -1.1 -1.0 -1.8 -2.3
Multivitamins +/- minerals 0.6 0.8 2.0 -0.7 -1.4 -0.8 -0.8 -1.2 -0.9 -0.6 0.3 -0.6 0.8 1.1 1.2 -1.1 -0.9 0.2 -0.6 -1.1 -1.2 -0.6 0.0 -1.0 -1.0
Stomach or abdominal pain in last month 0.5 0.6 3.4 0.6 0.5 0.4 0.7 0.5 0.3 0.4 -0.2 0.7 -0.7 -0.7 -0.7 0.9 0.9 1.8 1.1 0.0 0.8 -0.4 1.1 0.9 0.5
Supplements: Glucosamine 0.5 0.6 1.9 -0.5 -0.7 -1.2 -0.9 1.2 -0.5 -0.6 -1.3 -0.1 -1.2 -1.1 -1.2 -0.4 -0.3 -0.1 0.1 0.0 1.0 1.4 0.3 0.3 -0.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 5.0 -1.2 -1.6 -1.2 -1.1 0.3 -1.1 -1.6 -0.3 -1.4 -0.2 -0.0 -0.2 -0.7 -0.8 2.2 -1.1 1.4 0.5 -0.4 -0.3 -0.7 -0.8
Medication: Atenolol 0.2 0.2 2.3 -0.5 0.0 -0.3 -0.1 0.2 -0.6 -0.5 -0.5 -0.6 -0.1 0.1 0.1 -0.5 -0.3 1.5 -0.3 0.3 -0.4 -0.4 -0.1 -0.2 0.1
Medication: Levothyroxine sodium 1.8 3.0 7.8 2.1 1.7 1.3 1.6 0.7 1.7 1.5 -0.8 1.8 -1.6 -1.8 -1.8 2.2 2.2 2.8 2.2 1.1 1.0 1.2 1.6 2.0 1.9
Sitting height 0.6 4.1 8.5 -2.3 -2.6 -1.6 -1.7 -1.4 -2.2 -2.3 0.2 -2.9 1.5 1.8 1.8 -2.7 -2.5 1.6 -2.9 1.0 -1.5 -1.2 -2.3 -2.6 -1.8
Chronic bronchitis/emphysema (father) 0.6 0.7 3.1 -0.7 -0.7 -0.6 -0.9 -0.8 -0.6 -0.5 0.2 -0.6 0.6 0.7 0.8 -0.6 -0.8 0.4 -0.6 -0.4 -1.8 0.2 -1.6 -1.8 -0.8
High blood pressure (mother) 0.8 1.1 3.1 1.4 1.6 1.4 1.0 0.4 1.3 1.0 0.5 0.9 -0.1 -0.3 -0.4 1.2 1.3 1.8 0.8 1.3 0.6 -1.0 1.1 1.2 -0.1
Body mass index (BMI) 1.4 5.9 15.4 2.5 0.6 3.4 2.9 -2.9 2.3 3.3 3.9 2.1 3.1 2.5 2.7 2.0 1.1 2.9 1.8 -3.0 -0.7 -1.4 1.8 0.4 1.9
Impedance of leg (left) 0.6 2.8 10.2 -0.3 -0.2 -1.2 -1.0 2.4 -0.4 -1.1 -3.0 -0.0 -3.2 -3.0 -3.0 0.7 0.9 0.8 0.0 2.4 0.8 1.4 -0.6 0.7 -1.8
Leg predicted mass (left) 0.6 3.4 11.4 -0.3 -1.0 1.0 0.7 -3.2 -0.2 0.2 2.8 -1.0 3.4 3.3 3.3 -1.2 -1.5 0.8 -1.1 -0.9 -1.9 -2.4 -0.5 -2.1 0.5
Trunk fat mass 0.6 2.6 9.9 0.9 -0.7 2.0 1.5 -2.8 0.8 1.3 2.7 0.2 2.4 2.2 2.3 0.7 0.1 3.1 -0.1 -0.7 -1.1 -2.2 0.3 -0.6 0.1
Waist circumference 0.8 3.0 10.1 1.0 -0.6 2.0 1.5 -2.7 0.9 1.6 3.0 0.4 2.6 2.3 2.5 0.6 -0.2 3.2 0.2 -1.6 -0.8 -1.6 0.7 -0.6 1.2
Number of incorrect matches in round 0.2 0.3 1.1 -0.6 -0.3 -0.7 -0.8 0.2 -0.7 -0.7 -0.4 -0.7 -0.1 0.0 0.0 -0.7 -0.5 1.1 -0.8 0.1 0.0 -0.0 -0.5 -0.4 -1.1
Past tobacco smoking 0.1 0.1 0.7 0.1 -0.7 -0.4 0.4 0.4 -0.2 0.1 -0.2 0.0 -0.4 -0.3 -0.3 0.1 0.0 -0.3 0.5 -0.3 0.1 0.5 0.8 0.0 0.7
Alcohol usually taken with meals 0.1 0.1 0.6 -0.4 -0.0 -0.2 -0.3 -0.1 -0.4 -0.4 -0.8 -0.3 -0.3 -0.2 -0.2 -0.1 -0.1 0.1 -0.3 0.5 0.5 0.4 -0.0 0.6 0.7
Nervous feelings 0.1 0.1 0.5 -0.1 -0.3 0.1 -0.0 -0.7 -0.0 -0.0 0.5 -0.1 0.6 0.6 0.6 -0.3 0.0 0.4 -0.4 0.0 0.1 -0.7 -0.2 -0.1 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.5 0.5 0.0 0.6 0.5 -1.1 0.8 0.6 1.2 0.5 1.1 0.9 0.8 0.3 0.4 -0.7 0.4 -0.5 -0.7 -0.6 0.1 -0.8 -0.0
Hearing difficulty/problems with background noise 0.4 0.7 1.7 1.0 0.0 0.6 0.6 0.8 1.0 0.7 -0.3 1.0 -0.8 -1.0 -1.0 1.1 0.8 1.3 1.0 0.4 0.4 1.2 0.8 0.5 -0.3
Hair/balding pattern: Pattern 2 0.3 0.4 1.1 -0.7 -0.4 -1.0 -1.0 0.2 -0.8 -0.6 0.0 -0.5 0.3 0.3 0.4 -0.6 -0.9 0.5 -0.3 -1.0 -0.4 0.8 -0.9 -0.6 -0.4
Had menopause 1.1 1.4 5.4 -0.1 0.3 -0.7 -0.7 2.2 -0.6 -0.4 -2.1 0.0 -2.3 -2.1 -2.2 -0.0 0.4 1.0 0.2 1.1 -0.1 1.4 -0.2 0.3 -1.2
Had other major operations 0.2 0.2 2.4 -0.0 -0.7 0.1 0.2 -0.6 -0.0 0.1 0.4 -0.0 0.4 0.4 0.4 0.1 -0.5 1.6 -0.1 -0.6 0.1 0.0 -0.6 -0.7 0.2
Forced vital capacity (FVC) 1.1 4.1 7.7 -2.1 -1.7 -1.2 -1.2 -2.0 -2.0 -2.0 0.7 -2.6 1.8 2.1 2.1 -2.6 -2.5 0.3 -2.8 0.6 -2.2 -2.6 -1.7 -2.6 -2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 5.2 0.0 -1.0 0.6 0.6 -1.8 0.0 0.2 1.9 -0.4 2.2 2.2 2.3 0.1 -0.5 0.4 -0.7 -0.7 -0.8 -2.1 0.1 -1.1 -1.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.5 0.1 -0.5 0.6 0.3 -1.2 0.2 0.3 0.9 0.0 1.2 1.2 1.1 -0.2 -0.3 1.0 -0.0 -0.6 -1.1 -1.0 -0.1 -0.7 -0.3
Qualifications: None of the above 0.4 0.9 1.9 1.0 0.7 0.5 1.1 0.6 1.1 1.2 -0.1 1.4 -0.6 -0.8 -0.7 0.9 0.9 0.1 1.4 -1.2 1.2 1.1 1.0 1.1 0.5
Financial difficulties in last 2 years 1.2 1.6 4.2 1.4 1.0 1.7 1.7 -1.5 1.4 1.7 2.0 1.3 1.8 1.5 1.5 1.0 0.3 -0.1 0.9 -1.8 -0.7 -1.0 0.5 0.3 0.3
Mouth/teeth dental problems 1.2 1.9 5.5 0.9 -0.6 1.9 1.4 -2.0 0.6 1.0 2.3 0.2 2.2 2.2 2.2 0.6 0.5 0.5 -0.1 -0.4 -1.7 -2.4 0.0 -0.3 0.0
Heart attack 2.4 3.1 7.1 2.2 1.7 1.7 2.0 0.4 2.2 2.5 0.9 2.5 0.2 -0.2 -0.0 1.6 1.7 -0.7 2.3 -2.7 1.3 1.6 1.6 1.9 2.5
Allergy 1.3 3.0 11.1 2.1 3.3 1.8 1.7 0.8 2.2 1.9 -0.1 2.1 -0.8 -1.2 -1.3 1.9 2.4 -0.3 2.0 0.3 1.8 0.9 1.0 2.2 2.1
Pain all over the body in last month 0.3 0.4 3.1 0.4 -1.0 0.4 0.2 -0.1 0.3 0.2 0.5 0.1 0.3 0.2 0.2 0.3 0.2 1.8 0.3 0.4 -1.1 -0.2 -0.1 -0.7 -0.8
Diabetes (self-reported) 0.9 1.4 4.6 1.5 0.9 2.1 1.6 -1.0 1.3 1.7 1.5 1.1 1.0 0.8 0.8 1.2 1.0 0.7 1.0 -0.2 -0.0 -1.0 0.7 1.0 1.6
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 5.5 -0.7 -1.8 -0.2 -0.6 -1.2 -0.7 -0.5 1.3 -0.9 1.2 1.3 1.4 -0.7 -1.3 0.8 -1.2 -0.7 -1.4 -0.7 -1.5 -1.2 -2.3
Medication: Ramipril 0.8 1.1 2.8 1.1 1.3 1.0 0.7 1.2 1.0 0.9 -0.4 1.1 -1.1 -1.2 -1.3 1.3 1.0 1.1 1.0 1.0 0.8 -0.1 0.8 1.7 -0.2
Medication: Simvastatin 2.1 3.1 6.9 2.5 1.6 2.4 2.5 -0.0 2.6 2.3 1.2 2.3 0.1 -0.4 -0.4 2.4 2.4 1.6 2.2 -0.1 1.1 -0.2 2.1 1.8 1.3
Fluid intelligence score 0.2 0.4 3.4 -0.5 0.2 -0.2 -0.2 -0.7 -0.2 -0.7 -0.2 -0.7 0.1 0.2 0.1 0.0 -0.0 0.5 -0.7 1.5 0.3 -1.8 0.1 -0.3 -0.7
Illnesses of siblings 1.5 2.1 5.0 -1.8 -1.9 -0.9 -1.4 -1.0 -1.4 -1.8 0.5 -2.2 1.4 1.6 1.5 -1.4 -1.8 -0.1 -2.2 0.9 -1.4 -0.5 -1.5 -1.7 -0.3
Neuroticism score 0.2 0.4 4.8 0.1 0.0 -0.0 -0.3 -0.7 0.2 0.1 0.5 0.0 0.4 0.3 0.3 -0.2 -0.0 2.2 -0.1 -0.1 -0.8 0.5 -0.4 -0.4 -0.7
Weight 0.7 3.5 10.3 0.7 -0.6 2.0 1.5 -3.2 0.6 1.2 3.2 -0.1 3.2 3.0 3.1 -0.0 -0.6 2.7 -0.3 -1.1 -1.6 -2.5 0.2 -1.3 0.6
Impedance of arm (right) 2.5 11.6 27.8 -4.5 -3.3 -4.5 -4.5 1.4 -4.1 -5.3 -3.7 -4.3 -2.1 -1.2 -1.3 -3.2 -2.8 -2.4 -4.2 4.3 -0.8 -0.4 -3.4 -2.3 -4.6
Arm fat percentage (right) 0.6 2.3 7.0 1.1 -0.6 1.9 1.5 -2.4 0.9 1.5 2.6 0.6 2.2 2.0 2.1 1.1 0.2 2.4 0.4 -1.3 -0.9 -1.6 0.7 -0.3 0.1
Trunk fat-free mass 0.3 1.5 4.4 -0.0 -0.0 0.9 0.7 -1.9 0.0 0.2 1.6 -0.7 2.1 2.0 2.0 -1.0 -0.9 1.7 -0.6 -0.0 -1.1 -1.7 -0.1 -1.4 1.1
Hip circumference 0.7 2.9 9.7 0.8 -0.2 1.6 1.6 -2.8 0.7 1.4 3.1 0.4 2.9 2.6 2.8 0.3 -0.5 2.0 0.2 -2.1 -0.9 -1.9 0.6 -0.8 1.3
Time employed in main current job 1.3 1.5 4.9 -0.9 -0.4 -1.9 -1.7 2.1 -1.2 -1.0 -1.9 -0.4 -2.0 -1.7 -1.6 -0.8 -0.5 0.3 -0.0 -0.4 0.4 2.2 -0.5 -0.5 -0.1
Alcohol intake versus 10 years previously 4.0 5.9 17.0 -0.7 -1.7 1.0 0.4 -3.3 -0.5 0.1 3.4 -1.3 4.1 4.1 4.1 -1.5 -1.6 -1.3 -1.5 -1.6 -3.8 -3.5 -1.4 -3.1 -1.0
Father’s age at death 2.8 3.7 8.8 -2.2 -2.0 -3.0 -2.9 1.5 -2.5 -2.4 -2.4 -1.9 -1.7 -1.2 -1.2 -2.1 -1.9 -1.4 -1.9 0.5 -0.4 1.5 -1.9 -0.9 -2.3
Worrier / anxious feelings 1.2 2.3 5.3 -2.0 -0.7 -2.2 -2.0 0.8 -1.7 -2.3 -2.0 -1.8 -1.4 -1.1 -1.0 -1.5 -1.1 -0.4 -1.3 2.2 -0.7 0.5 -1.4 -1.8 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 2.4 0.5 -0.5 0.9 0.9 -0.6 0.8 0.6 1.2 0.4 0.9 0.8 0.8 0.9 0.6 0.9 0.3 -0.1 -1.6 -0.4 -0.3 -1.2 -0.5
Falls in the last year 0.1 0.1 0.7 0.0 -0.4 -0.1 0.1 -0.4 -0.0 0.1 0.1 0.1 -0.0 -0.0 0.0 -0.1 -0.1 0.8 0.3 -0.7 0.6 -0.0 0.8 0.4 0.1
Hair/balding pattern: Pattern 3 0.7 1.1 3.1 0.8 1.3 0.4 0.8 1.5 0.8 0.5 -1.1 0.8 -1.6 -1.7 -1.8 0.8 1.1 -0.9 0.9 1.0 0.7 0.6 0.5 0.7 0.7
Number of live births 0.4 0.6 3.0 -0.4 0.1 -0.6 -0.5 1.7 -0.6 -0.5 -1.1 -0.2 -1.5 -1.4 -1.3 -0.0 -0.1 0.5 0.1 0.3 0.6 1.0 -0.3 0.7 -0.1
Forced expiratory volume in 1-second (FEV1) 1.0 3.4 7.8 -2.5 -1.5 -1.8 -1.8 -0.7 -2.3 -2.5 -0.3 -2.8 0.6 1.0 1.0 -2.5 -2.4 0.1 -2.7 1.5 -1.6 -1.5 -1.7 -2.2 -2.1
Pulse rate 0.4 0.6 1.6 -0.9 -1.3 -0.7 -0.8 -0.9 -1.0 -0.8 0.3 -1.0 0.5 0.7 0.7 -0.6 -1.2 0.6 -1.0 -0.1 -0.5 -0.8 -0.5 -0.8 -0.6
Happiness 0.4 0.5 4.4 0.3 -0.7 0.3 0.6 -1.0 0.2 0.2 0.6 0.3 0.4 0.4 0.3 -0.4 0.2 2.1 0.6 -0.6 -1.1 -0.5 0.9 -0.9 0.9
Noisy workplace 1.7 2.1 7.1 1.7 1.5 1.9 1.8 -0.2 1.8 1.7 0.9 1.7 0.4 0.1 0.1 1.9 1.7 0.8 1.5 -0.7 1.3 0.0 1.5 2.0 2.7
Qualifications: A levels/AS levels or equivalent 1.6 3.5 7.7 -2.7 -2.5 -2.1 -2.8 -0.6 -2.7 -2.7 -0.8 -2.8 0.3 0.8 0.8 -2.1 -2.1 -1.2 -2.5 1.3 -0.8 -0.8 -1.3 -1.4 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 1.2 -0.1 0.8 0.3 -0.1 -0.5 -0.2 0.1 0.5 -0.2 0.6 0.6 0.7 -0.2 -0.3 -1.1 -0.3 -0.3 0.5 -1.0 0.4 0.7 -0.1
Mouth/teeth dental problems: Dentures 2.1 3.6 9.4 1.8 1.8 0.9 1.4 1.7 1.9 1.8 -0.6 2.4 -1.6 -1.9 -1.8 2.1 1.8 0.7 2.5 -0.7 3.1 1.6 2.3 2.8 2.1
Asthma 0.4 0.7 2.4 -0.2 -1.0 0.3 0.1 -1.3 -0.4 -0.1 0.9 -0.5 1.0 1.1 1.2 -0.2 -0.7 -0.1 -0.5 -0.3 -1.5 -1.4 0.0 -0.9 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.9 -0.4 -0.2 -0.8 -0.5 -0.6 -0.5 -0.3 -0.1 -0.2 0.8 0.9 0.8 -1.2 -1.0 0.3 -0.7 -1.4 -0.3 -0.4 -0.7 -0.6 -1.4
Medication: Cholesterol lowering 3.5 5.5 10.8 3.2 2.0 2.9 2.9 0.4 3.1 3.0 0.9 3.3 -0.5 -1.0 -1.0 3.3 3.2 0.9 3.3 -0.7 1.5 0.6 2.5 2.6 2.8
Depression (self-reported) 0.2 0.2 0.7 -0.4 -0.1 -0.6 -0.8 0.3 -0.4 -0.2 -0.2 -0.1 -0.2 -0.1 -0.2 -0.4 -0.5 -0.6 -0.2 -0.5 -0.9 0.7 -0.5 -0.8 -0.8
Medication: Lansoprazole 1.1 1.3 4.9 1.4 0.2 0.7 1.2 0.1 1.0 1.6 1.1 1.5 0.5 0.3 0.4 1.3 0.9 2.2 1.5 -2.2 -0.8 1.3 0.2 0.0 0.2
Prospective memory result 0.8 1.0 4.6 0.8 0.7 -0.1 0.2 1.3 0.5 0.8 -0.8 1.2 -1.3 -1.4 -1.5 0.6 0.4 -0.3 1.1 -1.5 0.5 2.1 0.2 0.7 0.3
Lung cancer (father) 0.5 0.6 3.1 -0.4 0.4 -0.8 -0.6 0.9 -0.3 -0.5 -0.8 0.1 -1.0 -1.0 -1.0 -0.0 -0.2 -0.8 0.1 0.1 1.8 1.1 -0.2 0.9 0.2
Illnesses of mother 0.6 0.7 2.6 -1.0 -0.5 -1.5 -1.0 0.4 -0.7 -0.7 -0.9 -0.3 -0.4 -0.3 -0.3 -0.9 -0.8 -1.1 0.1 -1.0 -0.5 1.6 -0.5 -1.2 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.8 9.7 -2.6 -2.6 -1.7 -1.8 -1.2 -2.5 -2.5 0.4 -3.0 1.5 1.9 1.9 -2.8 -2.7 -0.4 -2.9 0.7 -2.7 -1.4 -2.4 -3.1 -2.1
Pulse wave Arterial Stiffness index 0.3 0.3 2.0 -0.2 -0.4 0.0 -0.3 0.3 -0.2 -0.4 0.0 -0.5 0.1 0.1 0.2 -0.3 0.0 1.0 -0.8 1.2 -0.0 -1.1 -0.3 -0.2 -1.4
Impedance of arm (left) 1.9 9.0 21.3 -3.9 -2.9 -4.1 -4.0 1.6 -3.5 -4.6 -3.5 -3.6 -2.2 -1.5 -1.5 -2.7 -2.2 -2.5 -3.5 3.9 -0.1 0.1 -2.8 -1.6 -3.7
Arm fat mass (right) 0.8 3.5 10.8 1.2 -0.5 2.3 1.9 -3.1 1.1 1.8 3.3 0.6 3.0 2.7 2.8 0.9 0.1 2.8 0.3 -1.5 -1.1 -2.1 0.7 -0.5 0.7
Trunk predicted mass 0.2 1.4 4.1 -0.1 -0.0 0.8 0.6 -1.9 -0.0 0.2 1.6 -0.7 2.0 1.9 2.0 -1.0 -0.9 1.6 -0.6 -0.1 -1.0 -1.6 -0.2 -1.4 1.1
Standing height 0.9 8.9 20.7 -3.8 -2.6 -2.8 -3.0 -0.7 -3.4 -4.4 -1.6 -4.5 0.1 0.7 0.8 -4.0 -3.2 0.4 -4.3 4.3 -1.6 -2.3 -3.2 -3.5 -2.7
Length of working week for main job 1.4 1.6 5.4 -0.3 -1.2 0.3 0.6 -2.1 -0.2 0.2 1.7 -0.5 2.3 2.2 2.3 -0.4 -1.2 -0.6 -0.6 -1.7 -1.2 -1.0 -0.5 -1.1 0.3
Exposure to tobacco smoke at home 0.7 0.7 2.8 0.8 -0.8 1.7 1.4 -0.8 0.8 1.0 1.1 0.3 0.9 0.8 0.8 0.4 0.6 1.3 0.4 0.3 -0.4 -1.0 1.0 -0.1 -0.4
Breastfed as a baby 0.7 0.9 5.6 0.6 1.4 0.5 0.8 1.0 0.5 0.3 -0.5 0.4 -0.8 -0.7 -0.7 0.7 1.0 2.4 0.4 1.6 0.1 -1.2 0.8 0.4 0.4
Tense / ‘highly strung’ 0.1 0.2 0.9 -0.3 0.3 -0.3 -0.7 0.4 0.1 -0.5 0.2 -0.1 -0.0 -0.1 -0.2 -0.4 -0.1 0.4 -0.4 0.5 0.9 0.6 -0.3 0.2 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.2 -0.8 -0.9 -0.7 -0.6 -0.3 -0.6 -0.6 0.3 -0.5 0.5 0.6 0.5 -1.1 -1.0 0.8 -0.7 -0.4 -0.5 -0.3 -0.6 -0.9 -0.9
Hair/balding pattern: Pattern 4 0.3 0.7 1.6 1.1 0.5 1.2 1.0 -1.1 1.0 1.1 1.0 0.8 0.7 0.6 0.7 0.7 0.9 1.3 0.5 -0.6 -1.1 -0.9 -0.0 0.1 -0.5
Birth weight of first child 0.3 0.6 2.0 -0.7 -1.1 -1.2 -0.9 0.1 -1.1 -0.7 -0.6 -0.6 -0.3 -0.1 -0.1 -1.2 -0.7 0.8 -0.2 -0.9 0.2 1.4 -0.2 -0.3 1.3
Peak expiratory flow (PEF) 2.0 4.6 8.9 -2.8 -2.1 -2.5 -2.7 -1.1 -2.7 -2.5 -0.5 -2.8 0.8 1.3 1.3 -3.0 -3.0 -1.1 -2.9 -0.4 -1.6 -0.1 -2.8 -2.5 -2.3
Pulse wave reflection index 0.8 1.0 3.0 1.1 0.9 1.6 1.4 -0.4 1.3 1.2 1.7 0.8 1.2 0.9 1.0 0.8 0.7 1.1 0.4 -0.1 0.4 -0.8 0.8 0.8 0.5
Ever highly irritable/argumentative for 2 days 2.1 2.5 9.3 -0.5 -2.2 0.5 0.2 -1.9 -0.5 -0.0 2.0 -0.9 2.4 2.5 2.4 -0.7 -1.1 0.4 -1.1 -1.1 -3.0 -1.1 -1.7 -2.4 -0.8
Loud music exposure frequency 1.0 1.1 3.3 0.3 -0.3 0.8 0.5 -1.4 0.3 0.5 1.7 -0.0 1.8 1.7 1.6 -0.3 -0.4 1.6 -0.1 -1.2 -1.5 -0.5 -0.8 -0.9 0.1
Qualifications: O levels/GCSEs or equivalent 2.1 3.3 7.0 -1.7 -1.8 -0.4 -1.2 -2.0 -1.7 -1.6 1.4 -2.3 2.3 2.6 2.6 -1.6 -1.7 -0.5 -2.3 0.6 -2.5 -2.1 -1.7 -1.9 -0.9
Mouth/teeth dental problems: Bleeding gums 2.6 3.4 8.7 -2.6 -1.0 -2.7 -3.0 0.4 -2.2 -2.6 -1.8 -2.3 -0.9 -0.5 -0.5 -2.7 -2.0 -1.0 -2.2 1.6 -0.1 1.1 -1.9 -1.4 -1.5
Blood clot in the leg (DVT) 0.7 0.9 2.3 -1.5 -0.3 -0.9 -0.8 -0.4 -1.2 -1.0 -0.0 -1.3 0.8 0.9 0.8 -1.4 -1.0 0.5 -1.2 0.0 -0.9 -0.5 -1.2 -1.2 -0.6
Medication: Paracetamol 0.3 0.5 2.6 0.3 -0.1 0.2 0.3 -0.8 0.2 0.6 0.8 0.5 0.7 0.7 0.7 -0.0 -0.1 -0.9 0.4 -1.6 -1.4 0.2 -0.4 -1.0 -0.3
Headache pain in last month 0.7 1.2 5.4 -0.1 -0.5 -0.2 0.2 -1.5 -0.4 -0.2 1.0 -0.5 1.2 1.3 1.2 -0.9 -0.7 1.4 -0.8 -0.7 -2.3 -1.2 -1.2 -1.8 -1.5
Medication for cholesterol, blood pressure or diabetes 3.4 5.7 11.8 -3.3 -2.3 -3.4 -3.3 0.1 -3.1 -3.2 -1.6 -3.1 -0.2 0.3 0.3 -3.4 -3.0 -1.2 -3.0 0.9 -1.2 0.3 -2.3 -2.4 -2.9
Glaucoma (self-reported) 1.9 2.3 5.9 1.7 1.7 2.3 2.3 -0.3 1.9 1.7 1.4 1.3 0.6 0.3 0.2 2.0 2.4 1.8 1.1 0.8 0.5 -1.6 1.0 1.6 1.4
Gout (self-reported) 0.7 1.0 4.3 1.1 0.6 0.4 1.1 0.9 0.7 1.1 -0.1 1.2 -0.8 -0.9 -1.0 1.0 0.9 0.2 1.6 -0.9 -0.2 1.3 0.8 0.3 2.1
Hypothyroidism/myxoedema (self-reported) 1.6 3.1 11.1 2.4 1.8 1.7 1.8 0.1 1.9 1.8 -0.3 2.1 -1.0 -1.3 -1.4 2.5 2.2 3.3 2.4 0.4 -0.0 1.4 1.6 1.7 1.7
Medication: Amlodipine 0.3 0.5 1.2 1.0 0.7 1.1 1.1 -0.1 0.8 1.0 0.3 0.9 -0.2 -0.3 -0.3 1.1 0.9 0.6 0.9 -0.3 0.0 -0.1 0.4 0.5 0.4
Medication: Ventolin 100micrograms inhaler 2.5 3.2 6.7 -1.9 -1.8 -1.2 -1.1 -1.9 -1.8 -1.5 1.1 -2.0 1.8 2.1 2.3 -2.4 -2.6 -0.7 -2.1 -0.9 -1.7 -1.6 -1.6 -2.0 -1.4
Birth weight 0.1 0.3 2.2 0.3 0.3 0.1 0.4 -0.2 0.5 0.4 -0.2 0.5 -0.2 -0.3 -0.3 -0.1 0.4 -1.5 0.1 -0.7 0.5 -0.0 0.1 0.6 -0.9
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.7 0.0 -0.1 0.5 0.2 -1.6 0.2 0.0 1.4 -0.1 1.4 1.3 1.4 -0.4 -0.0 -0.1 -0.4 -0.6 -0.0 -1.2 -0.0 0.2 -0.4
High blood pressure (siblings) 1.3 1.8 4.4 1.6 2.1 0.8 1.1 1.2 1.3 1.2 -0.6 1.7 -1.5 -1.7 -1.7 1.3 1.6 0.8 1.7 0.5 1.8 0.5 1.2 1.9 0.1
Forced vital capacity (FVC), Best measure 2.0 7.4 15.1 -3.0 -3.1 -1.8 -1.9 -2.0 -2.9 -2.7 0.7 -3.5 2.2 2.7 2.8 -3.5 -3.4 -0.2 -3.6 0.4 -3.4 -2.3 -2.8 -3.9 -2.8
Body fat percentage 0.8 3.1 12.5 1.8 -0.3 2.5 2.1 -2.3 1.6 2.2 2.7 1.3 1.9 1.6 1.7 1.8 1.0 3.5 1.0 -1.4 -0.7 -1.4 1.0 0.1 0.3
Leg fat percentage (right) 1.4 5.2 15.7 3.1 0.7 3.4 3.0 -1.3 2.8 3.4 2.6 2.8 1.1 0.6 0.7 3.0 2.2 4.0 2.4 -1.7 0.2 -0.3 2.1 1.4 1.0
Arm fat-free mass (right) 0.6 3.0 8.0 1.4 0.3 2.3 1.9 -2.6 1.3 1.9 2.8 0.8 2.6 2.3 2.4 0.3 0.1 2.5 0.7 -1.8 -1.1 -1.4 0.7 -0.8 1.7
Exposure to tobacco smoke outside home 0.9 1.2 3.6 -0.1 -1.4 0.6 0.5 -1.9 -0.2 0.5 1.6 -0.3 1.8 1.8 1.9 -0.3 -0.7 -0.3 -0.5 -1.7 -1.5 -0.6 -0.6 -1.2 -0.4
Comparative body size at age 10 0.1 0.3 0.9 -0.7 0.0 -0.7 -0.3 -0.2 -0.5 -0.8 0.0 -0.7 0.3 0.3 0.4 -1.0 -0.8 0.4 -0.5 0.3 0.6 -0.6 0.3 -0.4 0.4
Number of full brothers 1.1 1.4 4.0 0.7 -1.2 1.2 0.9 -1.5 0.3 1.0 1.9 0.4 1.9 1.9 2.0 0.0 -0.0 -1.8 0.4 -1.6 -0.7 -1.3 0.8 -0.3 -0.2
Worry too long after embarrassment 0.4 0.7 2.8 0.2 0.3 0.6 0.5 -1.0 0.1 0.3 0.9 -0.1 0.9 0.9 0.9 -0.3 -0.0 1.2 -0.3 -0.2 -1.5 -1.4 -0.3 -0.9 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.7 -0.5 -0.3 -0.4 -0.6 0.0 0.0 -0.5 0.5 -0.3 0.6 0.5 0.5 -0.7 -0.5 -0.1 -0.4 0.0 -0.5 0.0 -0.3 -0.8 -0.5
Wheeze or whistling in the chest in last year 0.8 1.5 7.2 0.3 -1.2 0.9 0.6 -1.9 0.1 0.6 1.6 -0.2 1.7 1.7 1.8 -0.0 -0.4 1.0 -0.1 -1.2 -2.7 -1.0 -0.2 -1.9 -0.8
Number of children fathered 1.4 1.5 5.6 1.4 1.0 1.5 1.3 0.2 1.4 1.3 0.2 1.3 -0.1 -0.3 -0.3 1.6 1.1 2.4 1.1 -0.0 1.2 -0.2 1.4 1.7 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.9 -0.3 0.8 -0.6 -0.5 1.2 -0.1 -0.4 -1.2 0.1 -1.2 -1.2 -1.1 -0.0 0.1 -0.6 0.5 0.8 1.1 1.3 0.7 0.6 1.4
Age at first live birth 1.0 1.9 7.2 0.5 0.4 -0.4 -0.2 2.5 0.3 0.1 -2.2 0.7 -2.6 -2.6 -2.7 0.6 1.0 0.8 1.0 1.0 0.4 1.8 0.4 0.5 0.4
Pulse wave peak to peak time 0.2 0.2 1.4 -0.2 0.1 -0.5 -0.1 -0.3 -0.2 -0.1 -0.4 -0.0 -0.2 -0.2 -0.3 -0.1 -0.4 -0.9 0.4 -0.8 -0.2 1.2 -0.1 -0.2 1.2
Health satisfaction 0.4 0.6 4.6 0.4 -0.8 0.5 0.6 -1.1 0.3 0.2 0.7 0.2 0.6 0.6 0.6 0.3 0.1 2.2 0.4 -0.2 -1.2 -0.8 -0.1 -1.0 -0.1
Shortness of breath walking on level ground 2.8 3.3 9.8 1.7 0.1 2.1 2.4 -2.4 1.5 1.9 3.1 1.2 2.5 2.2 2.2 1.1 0.9 2.6 1.1 -2.0 -0.3 -2.2 1.0 -0.3 1.3
Qualifications: College or University degree 0.3 1.0 5.2 -0.7 -0.7 -1.0 -0.6 1.3 -0.7 -1.1 -1.7 -0.7 -1.5 -1.3 -1.4 0.0 0.2 0.3 -0.2 2.3 0.7 0.1 0.5 0.1 0.3
Eye problems/disorders: None of the above 3.7 4.3 10.8 -2.7 -3.3 -1.9 -2.3 -1.8 -2.5 -2.4 0.6 -2.8 1.7 2.1 1.9 -2.6 -3.0 -1.0 -2.7 0.1 -0.6 -1.1 -1.2 -1.8 -1.6
Mouth/teeth dental problems: Loose teeth 0.8 0.9 3.2 -0.2 0.9 -0.6 -0.5 1.5 -0.1 -0.4 -1.8 0.1 -1.6 -1.5 -1.5 0.6 0.2 -1.6 -0.3 1.0 0.6 1.1 -0.4 0.6 -0.6
Emphysema/chronic bronchitis 0.6 0.7 3.3 -0.5 -0.9 -0.2 -0.0 -0.5 -0.5 -0.5 0.6 -0.7 0.8 0.9 0.9 -0.7 -0.8 -0.2 -0.7 -0.4 -1.8 -0.8 -1.2 -1.8 -0.0
Medication for pain relief, constipation, heartburn 0.2 0.3 1.6 -0.5 -0.0 -0.1 -0.4 0.7 -0.2 -0.5 -0.6 -0.5 -0.4 -0.4 -0.5 -0.4 -0.3 -0.1 -0.4 1.3 0.9 -0.1 0.3 0.4 0.3
Neck or shoulder pain in last month 0.4 0.6 1.9 -0.8 0.6 -0.4 0.2 -0.6 -0.8 -0.4 0.5 -0.8 0.8 0.9 0.8 -0.8 -1.0 -1.4 -0.8 -1.0 -0.9 -1.0 -0.6 -0.9 0.2
Medication: Blood pressure 2.7 4.7 11.1 2.8 2.9 3.3 2.9 -0.1 2.7 2.7 1.6 2.4 0.4 -0.1 -0.1 2.8 2.7 1.5 2.2 0.0 1.8 -1.0 2.2 2.8 2.5
Angina (self-reported) 0.5 0.7 2.3 1.2 1.0 1.0 1.2 -0.7 1.0 1.3 0.8 1.1 0.4 0.2 0.2 0.5 0.6 0.6 0.9 -1.5 -0.0 0.0 0.7 0.4 0.3
Migraine (self-reported) 1.0 1.3 4.3 0.3 0.4 -0.3 -0.3 1.4 -0.1 -0.3 -1.8 0.2 -2.1 -1.9 -2.0 0.6 1.2 1.5 0.3 2.0 0.5 0.9 0.3 1.0 -0.3
Medication: Ibuprofen 0.5 0.6 1.8 -0.5 -0.4 -0.6 -0.5 -1.2 -0.4 -0.4 0.2 -0.3 1.1 1.1 1.1 -1.0 -1.1 -0.1 -0.8 -1.3 0.4 -0.4 -0.4 -0.3 -0.7
Medication: Allopurinol 1.7 2.3 6.5 0.8 1.4 -0.2 0.7 2.2 0.6 0.4 -1.5 1.1 -2.3 -2.4 -2.6 1.3 1.5 0.9 1.7 0.8 0.9 2.1 0.8 1.0 2.3
Medication: Omeprazole 0.5 0.6 3.0 1.0 0.6 0.5 0.9 -0.3 0.9 1.0 0.7 1.0 0.0 -0.2 -0.1 0.8 0.9 1.7 0.9 -0.9 0.1 0.6 0.4 0.4 0.6
Medication: Seretide 50 evohaler 1.7 1.9 4.5 1.7 2.1 1.2 1.4 1.4 1.4 1.7 -0.3 1.8 -1.1 -1.3 -1.3 1.7 2.0 1.4 1.8 -0.4 0.0 1.1 1.2 1.0 0.9
Mean time to correctly identify matches 2.1 4.0 8.3 2.3 2.3 2.1 2.1 1.4 2.3 2.0 -1.0 2.4 -1.7 -2.1 -2.0 2.5 2.9 2.4 2.2 0.9 1.7 0.7 2.0 2.6 0.8
Heart disease (mother) 0.3 0.4 3.8 -0.3 -0.4 -0.4 -0.1 -0.2 -0.4 -0.2 -0.0 -0.3 0.0 0.1 0.1 -0.3 -0.5 -2.0 -0.6 -0.5 -0.4 0.0 -1.0 -0.4 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 2.3 1.2 1.5 1.1 0.9 -0.5 1.4 1.3 1.1 1.1 0.5 0.1 0.1 0.7 0.9 -1.5 0.5 -0.7 0.9 0.4 0.5 1.0 -0.1
Whole body fat mass 0.8 3.2 11.1 1.4 -0.5 2.3 1.9 -2.8 1.2 1.9 3.0 0.8 2.5 2.2 2.4 1.0 0.3 3.3 0.4 -1.5 -1.0 -1.8 0.6 -0.4 0.4
Leg fat mass (right) 1.2 4.5 12.4 2.4 0.1 3.2 2.7 -2.5 2.2 2.9 3.3 1.8 2.4 1.9 2.0 1.9 1.1 3.5 1.5 -1.9 -0.7 -1.4 1.4 0.3 1.0
Arm predicted mass (right) 0.6 2.9 7.8 1.3 0.3 2.1 1.9 -2.5 1.2 1.8 2.8 0.7 2.7 2.3 2.4 0.1 -0.1 2.2 0.7 -1.9 -1.2 -1.2 0.6 -0.9 1.8
Pulse rate, automated reading 0.1 0.4 1.1 0.4 -0.6 0.4 0.4 -1.1 0.2 0.4 1.0 0.2 1.0 1.0 1.0 0.1 0.1 0.1 0.2 -0.5 -0.5 -1.1 0.5 -0.6 -0.0
Alcohol intake frequency. 0.9 2.2 7.6 -0.1 -1.2 1.4 0.8 -2.8 -0.1 0.4 2.1 -0.7 2.6 2.6 2.6 -0.5 -0.4 -1.0 -1.0 -0.2 -1.2 -2.6 -0.3 -0.5 -0.4
Comparative height size at age 10 0.5 2.9 13.8 0.0 -0.4 1.4 1.1 -3.3 0.1 0.1 2.2 -1.0 2.8 2.7 2.8 -0.9 -0.6 0.8 -1.2 0.8 -1.6 -3.7 -0.0 -1.0 -0.4
Number of full sisters 0.4 0.5 1.7 0.6 -0.4 1.3 0.8 -1.0 0.6 0.9 1.3 0.3 0.9 0.7 0.8 0.8 0.2 0.8 0.4 -0.4 -0.5 0.2 0.2 -0.1 0.3
Suffer from ‘nerves’ 0.2 0.3 2.2 0.5 0.2 0.3 0.3 -0.5 0.6 0.8 0.9 0.6 0.7 0.6 0.5 0.0 0.4 -0.0 0.6 -1.5 -0.7 0.6 0.1 -0.4 0.1
Overall health rating 1.5 3.2 7.3 2.2 1.0 2.3 2.3 -2.1 2.3 2.6 2.5 2.2 1.7 1.2 1.3 1.7 1.2 2.0 1.8 -2.7 -0.6 -0.4 1.0 0.2 1.0
Chest pain or discomfort 1.6 2.3 6.9 0.7 -1.1 1.1 1.5 -2.1 0.6 1.2 2.6 0.4 2.4 2.3 2.2 0.3 -0.2 1.7 0.1 -2.2 -1.4 -1.6 0.4 -1.3 -0.6
Had major operations 0.8 1.0 2.1 -1.4 -0.8 -1.2 -1.0 0.5 -1.3 -1.5 -1.2 -1.3 -0.7 -0.4 -0.4 -0.9 -1.1 -0.1 -1.2 1.3 0.0 -0.7 -0.8 -0.4 -1.4
Age at last live birth 0.5 0.7 2.3 1.2 0.1 1.0 0.8 0.4 1.0 1.4 0.3 1.3 -0.0 -0.2 -0.2 0.8 0.4 -1.2 1.1 -1.5 0.2 1.0 0.2 0.8 0.7
Family relationship satisfaction 1.3 1.6 4.3 1.9 1.4 1.5 1.7 0.2 1.9 1.7 0.2 2.1 -0.3 -0.5 -0.6 1.6 1.8 0.3 1.9 -0.3 -0.2 0.1 1.2 0.5 1.3
Leg pain on walking 0.3 0.4 1.7 0.5 -0.4 0.5 0.5 -0.9 0.5 0.7 0.9 0.6 0.6 0.5 0.5 0.5 0.4 0.8 0.6 -1.3 -0.3 0.2 0.8 0.3 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 3.6 -1.4 -1.0 -1.1 -1.4 -1.3 -1.3 -0.9 1.0 -1.3 1.4 1.5 1.5 -1.8 -1.9 1.2 -1.7 -1.2 -0.9 -0.2 -1.9 -1.3 -0.9
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.1 -0.7 0.5 -1.3 -1.1 1.5 -0.7 -0.6 -1.1 -0.3 -1.0 -1.0 -0.9 -0.1 -0.6 -0.0 -0.1 -0.5 0.4 1.8 -1.0 -0.2 1.4
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 3.1 -1.1 -1.2 -0.9 -1.1 -0.5 -1.1 -0.9 0.2 -1.2 0.4 0.5 0.5 -1.6 -1.3 0.1 -0.9 0.1 -1.0 -0.2 -0.9 -1.8 -0.7
Medication: Aspirin 0.9 1.1 3.8 1.2 1.1 1.3 1.5 -0.1 1.1 1.1 0.4 0.9 -0.2 -0.4 -0.4 1.6 1.7 1.2 1.2 0.4 0.7 -0.2 0.9 1.0 2.0
Supplements: Vitamin C 1.3 1.6 5.0 0.2 1.0 -0.2 -0.3 2.2 0.3 -0.3 -1.6 0.4 -2.0 -2.1 -2.0 0.8 1.2 0.3 0.6 1.8 1.5 1.2 0.8 1.6 0.5
Knee pain experienced in last month 2.4 3.8 7.9 2.6 1.8 2.0 2.5 -0.1 2.6 2.6 1.0 2.8 0.2 -0.3 -0.3 2.5 2.1 -0.2 2.7 -2.1 2.0 0.4 2.4 2.3 1.4
Hypertension (Self-reported) 1.0 2.8 9.4 1.7 1.7 2.2 2.1 -0.5 1.8 1.7 1.3 1.5 0.3 -0.1 -0.1 2.3 2.1 3.1 1.6 0.9 1.4 -1.5 1.8 1.8 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 6.0 1.1 -0.2 0.8 0.9 -1.5 0.9 1.1 1.6 1.0 1.0 0.8 0.9 0.6 0.6 2.4 1.0 -1.6 -0.5 -0.3 0.3 -0.1 0.4
Illnesses of father: Heart disease 0.4 0.6 7.6 0.2 0.8 0.3 0.9 -0.2 0.2 0.5 0.2 0.4 0.3 0.4 0.4 0.0 0.2 -2.8 0.4 -0.5 -1.1 -1.1 0.0 -0.7 0.1
Illnesses of siblings: Diabetes 0.4 0.5 5.1 -0.3 -0.7 -0.7 -0.6 -0.4 -0.8 -0.2 -0.6 -0.2 -0.5 -0.3 -0.1 -0.7 -0.5 -0.2 -0.4 -0.7 -0.9 0.2 -0.4 -0.4 -2.2
Smoking status: Previous 0.1 0.2 0.8 -0.4 0.7 -0.0 -0.6 -0.2 -0.3 -0.2 -0.0 -0.2 0.2 0.3 0.3 -0.5 -0.4 -0.3 -0.4 -0.2 -0.3 -0.4 -0.9 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 7.9 -2.2 -1.3 -1.6 -1.5 -1.4 -1.9 -2.5 0.0 -2.6 1.1 1.4 1.5 -2.4 -2.0 0.7 -2.8 1.8 -2.0 -2.0 -2.6 -2.6 -2.4
Whole body fat-free mass 0.4 2.4 7.9 0.1 -0.2 1.2 0.9 -2.6 0.2 0.5 2.4 -0.6 2.8 2.6 2.7 -0.9 -1.0 1.5 -0.6 -0.7 -1.5 -2.0 -0.2 -1.7 1.0
Leg fat-free mass (right) 0.9 4.6 14.7 -0.6 -1.1 0.8 0.4 -3.6 -0.5 -0.0 2.9 -1.4 3.8 3.7 3.8 -1.6 -1.8 0.5 -1.5 -1.0 -2.5 -3.0 -0.9 -2.6 0.0
Arm fat percentage (left) 0.7 2.7 8.5 1.4 -0.5 2.2 1.8 -2.5 1.2 1.9 2.9 1.0 2.3 2.0 2.1 1.4 0.6 2.4 0.7 -1.5 -0.8 -1.6 0.9 -0.1 0.4
Average weekly red wine intake 1.6 2.4 6.5 -2.0 -1.1 -2.1 -2.2 0.7 -2.1 -2.5 -1.9 -1.9 -1.2 -0.8 -0.7 -1.0 -1.4 -0.7 -1.9 2.2 -0.6 0.0 -1.6 -0.9 -1.0
Handedness (chirality/laterality): Left-handed 0.9 1.0 2.7 -1.1 -1.6 -0.6 -1.2 -0.9 -1.0 -0.7 0.5 -0.9 1.1 1.2 1.2 -1.3 -1.4 -1.0 -1.3 -0.9 0.0 -0.4 -0.8 -0.5 -1.1
Mood swings 0.3 0.6 5.1 0.9 0.8 0.4 0.1 -0.6 0.6 0.8 0.2 0.8 -0.2 -0.3 -0.3 0.7 0.7 2.3 0.5 -0.5 -0.2 1.6 0.1 0.7 0.4
Loneliness, isolation 0.5 0.7 2.1 1.0 1.4 0.7 0.9 0.5 1.0 0.6 0.1 0.9 -0.5 -0.7 -0.7 1.2 1.4 1.0 1.1 0.9 -0.4 0.2 0.5 0.3 1.2
Long-standing illness, disability or infirmity 0.9 1.3 3.3 1.4 0.3 1.6 1.7 -1.0 1.2 1.7 1.8 1.2 1.1 0.8 0.8 1.2 0.9 1.3 1.1 -1.5 -0.5 -0.1 0.9 0.5 0.9
Ever had bowel cancer screening 0.2 0.2 3.1 -0.1 -0.0 -0.3 0.0 0.4 0.1 -0.2 -0.1 -0.1 -0.2 -0.3 -0.2 0.1 0.3 0.6 -0.1 -0.1 1.8 0.0 0.1 0.6 0.2
Diabetes diagnosed by doctor 0.9 1.5 4.6 1.8 1.0 2.1 1.7 -0.4 1.5 1.7 1.1 1.3 0.4 0.1 0.1 1.4 1.4 0.9 1.4 0.3 0.3 -0.7 1.1 1.2 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.7 0.5 -0.7 1.0 0.1 -1.1 0.8 1.0 1.6 0.4 1.5 1.2 1.1 -0.0 -0.3 -0.2 -0.1 -1.5 -0.7 0.7 -1.2 -0.7 0.3
Friendships satisfaction 0.4 0.5 1.4 0.8 0.6 0.7 0.7 -0.4 0.9 0.7 -0.1 0.9 -0.3 -0.4 -0.4 0.8 1.2 1.2 1.0 0.4 0.2 0.2 0.9 0.4 1.0
Qualifications: nursing, teaching 1.8 2.9 5.8 -2.1 -1.8 -2.0 -2.1 1.2 -2.4 -2.4 -2.2 -2.1 -1.4 -0.8 -0.8 -1.4 -1.4 0.4 -1.8 2.1 -1.8 0.2 -1.5 -1.4 -1.5
Commuting to job workplace: Walk 0.6 0.6 5.9 0.0 0.6 0.6 0.8 0.0 0.1 -0.4 -0.0 -0.4 0.0 0.1 0.1 -0.2 0.3 -0.5 -0.2 2.1 0.2 -2.4 0.7 0.2 -0.5
Eye problems/disorders: Cataract 1.0 1.2 3.2 1.4 1.5 0.9 0.9 0.5 1.2 1.6 -0.2 1.8 -0.5 -0.6 -0.5 1.1 1.2 -0.4 1.8 -1.7 -0.8 1.2 0.5 0.3 0.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 3.1 -0.3 0.5 -1.0 -0.8 1.5 -0.2 -0.3 -1.1 0.2 -1.4 -1.4 -1.6 -0.4 -0.1 -0.2 0.3 -0.1 0.5 1.7 -0.1 0.1 -0.6
Medication for cholesterol 0.3 0.5 3.3 0.6 0.3 1.2 0.6 0.1 0.8 0.8 0.6 0.6 0.7 0.5 0.6 0.3 0.1 -1.8 0.3 -0.7 -0.6 0.5 0.1 -0.2 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.6 -0.9 -1.0 -0.4 -0.3 -1.7 -0.8 -0.9 1.3 -1.1 1.8 1.9 1.9 -1.0 -1.1 1.0 -1.4 -0.2 -0.3 -1.7 -0.6 -0.5 -0.8
Back pain experienced in last month 0.7 1.0 2.8 0.2 -0.8 0.5 0.3 -1.7 0.4 0.3 1.6 -0.0 1.6 1.4 1.4 0.1 -0.1 1.2 -0.2 -1.1 -1.7 -0.6 -0.8 -1.4 -0.6
Mineral and other dietary supplements 0.3 0.4 1.9 0.3 0.6 0.6 0.2 -0.7 0.4 0.3 1.2 -0.0 0.9 0.7 0.7 0.1 0.0 1.4 -0.4 -0.0 -0.3 -0.2 -0.7 -0.1 -0.3
Breast cancer (self-reported) 0.9 1.1 4.5 -1.1 -0.7 -0.9 -1.3 0.5 -0.8 -1.5 -1.0 -1.2 -0.4 -0.2 -0.3 -0.6 -0.6 -1.4 -1.3 2.1 -0.2 -0.0 -1.1 -0.6 -1.4
Asthma (self-reported) 0.3 0.6 2.5 -0.4 -1.1 0.0 -0.2 -1.1 -0.6 -0.2 0.5 -0.6 0.7 0.9 0.9 -0.4 -0.8 -0.6 -0.6 -0.2 -1.6 -0.9 -0.3 -0.9 -1.4
Osteoporosis (self-reported) 2.7 3.3 9.1 2.3 0.9 1.8 2.0 -0.6 2.2 2.7 1.6 2.6 0.6 0.2 0.3 1.4 1.5 0.5 2.5 -3.0 1.5 0.6 2.9 1.9 1.6
Osteoarthritis (self-reported) 0.6 0.7 1.9 0.8 0.5 0.6 1.1 0.8 0.8 0.5 -0.1 0.6 -0.5 -0.7 -0.7 1.3 1.3 0.7 0.7 0.9 1.2 -0.5 1.4 1.1 0.6
Medication: Aspirin 0.7 0.9 3.8 1.1 0.9 1.3 1.5 -0.3 0.9 1.0 0.6 0.8 0.0 -0.1 -0.1 1.3 1.5 0.8 1.1 0.2 0.4 -0.5 0.9 0.8 1.9
Medication: Gliclazide 1.4 1.6 4.5 1.3 0.8 2.0 1.7 -1.2 1.3 1.7 2.1 0.9 1.6 1.3 1.4 0.9 0.8 1.0 0.6 -0.9 0.4 -1.3 1.0 0.6 1.2
Illnesses of father: None of the above (group 1) 1.2 1.4 3.4 1.4 0.4 0.9 0.6 0.9 1.1 1.1 -0.2 1.4 -0.8 -1.0 -1.0 1.3 1.1 1.7 1.5 -0.4 1.7 1.4 1.8 1.8 1.1
Smoking status: Current 0.7 1.1 4.3 0.2 -0.7 1.2 0.7 -1.8 0.6 0.2 1.8 -0.3 1.8 1.7 1.7 -0.1 0.1 -0.9 -0.6 0.5 -0.7 -2.1 0.3 -0.5 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 3.5 -0.3 0.2 -0.6 -0.7 -0.1 -0.4 -0.5 0.2 -0.4 -0.1 -0.1 -0.1 -0.3 -0.3 1.9 -0.5 -0.1 -0.3 0.3 -0.6 -0.1 -0.7
Whole body water mass 0.4 2.5 8.1 0.2 -0.2 1.3 1.0 -2.7 0.3 0.6 2.4 -0.5 2.8 2.7 2.7 -0.8 -0.9 1.6 -0.5 -0.8 -1.5 -2.0 -0.1 -1.6 1.1
Leg predicted mass (right) 0.9 4.7 14.8 -0.6 -1.1 0.8 0.4 -3.7 -0.5 -0.0 3.0 -1.4 3.8 3.8 3.9 -1.6 -1.8 0.5 -1.5 -1.0 -2.6 -2.9 -0.9 -2.6 0.0
Arm fat mass (left) 0.8 3.4 10.5 1.4 -0.4 2.4 1.9 -2.9 1.2 1.9 3.2 0.8 2.8 2.5 2.6 1.0 0.3 2.9 0.5 -1.6 -1.0 -1.7 0.8 -0.3 0.8
Number of self-reported non-cancer illnesses 3.3 5.8 12.2 3.1 1.7 3.2 3.3 -0.5 3.1 3.0 2.3 2.9 0.6 0.1 0.1 3.4 3.3 3.5 2.8 -0.1 0.7 -1.0 2.8 2.0 2.0
Average weekly champagne plus white wine intake 1.2 1.6 4.8 0.9 1.0 0.6 0.6 1.8 0.8 0.2 -1.2 0.6 -1.8 -1.9 -1.9 1.4 1.1 2.2 0.8 2.0 1.1 0.7 0.8 1.1 1.0
Miserableness 0.5 0.9 5.0 1.2 0.8 1.0 1.1 -1.1 1.1 1.3 1.3 1.1 0.8 0.6 0.6 0.8 0.8 2.2 0.7 -0.9 -0.2 -0.3 0.1 0.3 0.4
Guilty feelings 0.2 0.2 1.0 0.4 -0.1 0.0 0.1 0.1 0.3 0.3 -0.5 0.5 -0.4 -0.4 -0.4 0.4 0.4 0.8 0.3 0.1 -1.0 0.6 -0.5 -0.2 -1.0
Wears glasses or contact lenses 1.4 1.6 5.3 0.1 0.3 -0.7 -0.6 2.0 -0.1 -0.3 -2.1 0.4 -2.3 -2.3 -2.3 0.9 1.0 1.6 0.5 1.0 0.8 1.8 0.0 0.9 -0.2
Ever taken oral contraceptive pill 0.2 0.3 0.9 0.4 0.4 -0.0 0.3 1.0 0.3 0.3 -0.7 0.5 -0.8 -0.8 -0.8 0.5 0.3 0.4 0.4 0.6 -0.0 -0.3 0.3 -0.1 -0.2
Hearing aid user 0.4 0.5 3.4 -0.0 -0.8 -0.4 -0.9 0.1 -0.1 -0.3 -0.3 0.1 -0.6 -0.6 -0.6 0.1 -0.5 1.8 -0.2 0.1 0.8 1.3 -0.1 0.9 -0.5
Mother’s age at death 0.7 0.9 2.2 -1.1 -0.3 -1.1 -1.2 1.0 -1.0 -1.1 -1.5 -1.0 -1.0 -0.8 -0.9 -0.6 -0.2 -0.5 -0.8 1.5 -0.1 1.1 -1.5 -0.1 -0.2
Financial situation satisfaction 1.5 1.9 5.3 2.0 0.9 1.9 2.3 -1.0 2.1 2.0 1.1 1.9 0.6 0.2 0.2 1.7 1.2 1.1 1.6 -0.9 -0.0 0.1 1.4 0.5 1.5
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.7 -0.2 -0.4 -0.2 -0.7 -0.2 -0.7 -0.2 -0.0 -0.3 0.0 0.2 0.2 -0.4 -0.6 0.9 -0.5 -0.3 0.3 0.2 -0.4 0.5 -0.0
Commuting to job workplace: Public transport 2.3 2.7 10.6 -1.6 -2.0 -0.7 -1.2 -0.9 -1.5 -1.8 -0.2 -2.1 0.6 1.0 0.9 -1.4 -1.3 -0.6 -2.4 2.3 -1.6 -2.0 -1.8 -1.5 -3.3
Eye problems/disorders: Glaucoma 1.5 1.8 4.7 1.7 1.3 2.0 1.8 -0.1 1.8 1.6 1.2 1.4 0.3 -0.0 -0.1 2.0 2.2 1.7 1.1 0.8 0.4 -0.6 0.7 1.5 1.1
Medication: Blood pressure 0.2 0.4 4.0 0.1 -0.4 -0.1 0.1 -0.4 -0.2 0.1 0.3 -0.0 -0.1 -0.0 -0.1 0.3 0.2 2.0 0.0 0.2 0.4 -1.0 0.2 0.6 -1.3
Pain type(s) experienced in last month: Hip pain 0.6 0.7 3.0 -0.0 -0.9 0.2 0.3 -0.7 -0.1 0.4 1.1 -0.1 1.2 1.2 1.2 -0.5 -0.7 -1.2 -0.3 -1.7 -1.3 -0.1 -0.3 -0.9 -0.7
Supplements: Fish oil (including cod liver oil) 0.2 0.3 2.3 0.5 -0.2 0.6 0.3 -0.1 0.2 0.5 -0.5 0.6 -0.4 -0.3 -0.3 0.4 0.4 -1.5 0.6 0.1 -0.1 -0.3 1.1 0.5 -0.1
High cholesterol (Self-reported) 3.8 6.7 13.0 3.6 2.5 3.1 3.5 0.0 3.5 3.5 1.5 3.6 -0.0 -0.6 -0.7 3.2 3.2 1.3 3.6 -1.4 1.9 -0.4 3.2 2.9 2.6
Medication: Bendroflumethiazide 1.4 2.1 5.4 1.4 0.6 2.3 1.7 -1.9 1.6 1.6 2.3 0.9 1.9 1.5 1.6 1.5 1.3 1.6 0.7 -0.2 0.6 -1.9 0.9 1.1 0.9
Medication: Paracetamol 0.5 0.8 6.2 0.2 -0.1 0.1 0.3 -1.3 0.2 0.7 1.3 0.5 1.3 1.2 1.2 -0.3 -0.4 -0.8 0.4 -2.5 -1.2 0.0 -0.3 -0.8 0.1
Medication: Lisinopril 0.5 0.6 3.7 -0.0 0.1 0.2 0.2 -1.5 -0.2 0.1 1.2 -0.3 1.0 1.0 1.0 -0.3 -0.2 1.9 -0.2 -0.8 -0.3 -0.9 -0.6 -0.3 0.2
Medication: Atorvastatin 0.9 1.1 2.8 1.4 0.5 0.6 1.0 0.5 1.0 1.0 -0.2 1.4 -1.0 -1.2 -1.2 1.2 1.2 1.4 1.7 -0.6 1.1 0.6 0.9 0.9 0.5
Illnesses of father: High blood pressure 0.2 0.3 1.1 -0.6 0.3 -0.5 -0.7 -0.5 -0.6 -0.6 -0.0 -0.6 0.0 0.1 0.1 -0.5 -0.6 0.1 -0.8 0.4 0.5 -0.4 -0.8 0.2 -1.0
Alcohol drinker status: Never 0.2 0.2 1.8 -0.4 -0.4 -0.4 -0.4 0.6 -0.7 -0.3 -0.7 -0.4 -0.3 -0.2 -0.2 -0.5 -0.5 -1.4 -0.3 -0.0 -0.3 0.2 -0.2 -0.0 -0.7
Ever smoked 0.1 0.1 0.6 0.0 0.8 0.4 -0.4 -0.6 0.3 -0.0 0.3 0.1 0.3 0.3 0.2 0.1 0.1 0.1 -0.4 0.3 0.3 -0.6 -0.5 0.3 -0.7
Basal metabolic rate 0.5 3.0 9.7 0.3 -0.4 1.5 1.2 -3.0 0.4 0.8 2.8 -0.4 3.1 2.9 3.0 -0.7 -0.9 1.8 -0.5 -0.9 -1.6 -2.2 -0.0 -1.6 1.0
Leg fat percentage (left) 1.5 5.4 17.5 3.1 0.8 3.5 3.0 -1.7 2.6 3.5 2.9 2.6 1.6 1.0 1.2 2.9 2.1 4.2 2.2 -1.9 -0.2 -0.9 1.9 1.2 0.7
Arm fat-free mass (left) 0.6 2.8 7.3 1.1 0.4 2.0 1.8 -2.6 1.0 1.6 2.7 0.4 2.6 2.4 2.4 0.1 -0.1 2.7 0.4 -1.3 -1.4 -1.6 0.4 -1.1 1.6
Number of operations (self-reported) 1.2 1.8 3.8 -1.9 -1.8 -1.8 -1.8 0.8 -1.7 -1.9 -1.2 -1.6 -0.7 -0.3 -0.5 -1.1 -1.5 0.3 -1.6 0.9 0.3 0.5 -1.5 -0.8 -1.9
Average weekly beer plus cider intake 0.8 1.2 2.6 1.3 1.1 1.2 1.2 -0.0 1.4 1.4 0.6 1.4 -0.2 -0.4 -0.4 1.6 1.3 1.4 1.5 -0.1 0.4 0.1 1.3 0.7 1.6
Irritability 1.1 1.8 7.0 -0.5 -1.5 -0.2 -0.6 -1.8 -0.5 -0.5 1.2 -0.8 1.5 1.7 1.7 -0.6 -0.8 1.3 -1.2 -0.2 -2.6 -0.7 -1.6 -1.7 -2.6
Risk taking 0.1 0.1 0.7 -0.4 -0.4 -0.3 -0.1 -0.0 -0.2 -0.2 0.2 -0.2 0.2 0.2 0.1 -0.2 -0.4 -0.3 -0.2 -0.4 0.5 -0.0 0.2 -0.1 0.8
Ever had prostate specific antigen (PSA) test 0.9 1.1 3.6 0.9 1.0 1.0 1.1 -0.1 1.3 0.4 0.2 0.7 -0.1 -0.4 -0.4 1.3 1.1 1.7 0.4 1.4 1.9 -0.5 0.9 1.7 1.3
Fractured/broken bones in last 5 years 1.0 1.3 4.0 -1.7 -0.8 -2.0 -1.7 0.9 -1.6 -1.5 -1.2 -1.1 -0.6 -0.4 -0.3 -1.6 -1.7 -0.6 -0.5 -0.6 0.8 1.1 0.3 -0.4 0.8
Age started oral contraceptive pill 2.8 3.5 11.9 -0.4 -0.3 -1.8 -1.6 3.2 -0.7 -1.2 -3.2 -0.0 -3.5 -3.2 -3.2 -0.1 0.6 -0.8 0.1 1.8 1.8 2.7 0.1 1.3 -0.8
Diastolic blood pressure, automated reading 0.2 0.6 3.0 0.5 0.2 0.8 0.6 -1.0 0.8 0.8 1.7 0.5 1.2 1.0 0.9 0.4 0.3 1.0 0.6 -0.4 -0.7 -0.6 0.3 -1.0 0.4
Ever depressed for a whole week 0.6 0.8 6.0 1.0 0.3 0.9 0.4 0.5 1.0 1.0 0.1 1.2 -0.4 -0.5 -0.5 0.7 0.8 2.5 1.2 -0.0 0.4 0.7 1.0 0.8 0.2
Unable to work because of sickness or disability 0.7 1.0 3.3 0.9 0.1 1.3 1.1 -0.3 1.2 0.9 1.2 0.8 1.0 0.8 0.8 0.7 0.9 1.8 0.7 0.3 -1.8 -1.2 0.2 -0.9 -0.2
Commuting to job workplace: Cycle 1.4 1.7 3.8 0.2 1.1 -0.4 -0.2 1.9 0.1 -0.3 -1.9 0.4 -1.9 -1.9 -2.0 0.9 0.9 -0.8 0.9 1.5 1.8 1.8 1.0 1.4 1.7
Myopia 1.1 1.6 4.6 -1.3 -1.2 -1.2 -1.6 -0.6 -1.2 -1.0 0.1 -1.3 0.8 1.0 1.0 -1.8 -1.7 0.3 -1.6 -0.5 -1.2 -0.5 -1.7 -1.8 -2.1
Vascular/heart problems diagnosed by doctor 1.2 3.2 6.8 -2.1 -1.9 -2.2 -2.3 0.3 -2.1 -2.0 -1.1 -2.0 -0.0 0.3 0.4 -2.5 -2.4 -2.6 -2.1 -0.3 -1.4 1.3 -2.0 -1.9 -1.8
Cholesterol lowering medication 1.2 1.7 4.3 1.8 1.6 1.4 2.1 -0.5 1.6 1.7 0.8 1.7 0.0 -0.3 -0.3 1.4 1.8 1.6 1.6 -0.7 1.0 -1.0 1.5 1.2 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 2.4 -0.1 -0.1 -0.5 -0.1 -0.0 -0.2 -0.2 0.1 -0.1 -0.2 -0.1 -0.1 0.0 0.0 1.5 -0.0 -0.3 -0.6 0.8 -0.6 -0.4 0.2
Pain experienced in last month 0.3 0.5 1.7 -0.8 -0.2 -0.6 -1.1 0.4 -0.7 -0.8 -0.6 -0.7 -0.3 -0.2 -0.1 -0.6 -0.5 -0.8 -0.9 1.0 1.3 0.4 -0.1 1.0 -0.2
Supplements: Calcium 1.6 1.8 5.5 -1.6 -2.3 -1.1 -1.1 -0.5 -1.3 -1.2 0.3 -1.5 1.1 1.3 1.2 -2.0 -1.7 -2.0 -1.5 0.1 -1.0 -0.6 -0.6 -1.4 -1.5
Basal cell carcinoma (self-reported) 0.6 0.8 2.1 -0.8 0.6 -1.4 -1.2 0.9 -0.9 -1.0 -1.5 -0.3 -1.1 -0.9 -0.9 -1.1 -0.8 -0.3 -0.3 0.2 1.4 0.1 -0.4 0.6 0.0
Heart attack/myocardial infarction (self-reported) 2.5 3.3 6.7 2.3 2.0 1.8 2.1 0.5 2.3 2.5 0.8 2.6 0.1 -0.4 -0.2 1.8 2.0 -0.8 2.4 -2.3 1.5 1.4 1.8 2.1 2.4
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.4 -1.2 -0.3 -0.7 -0.6 -0.5 -0.9 -0.6 0.4 -0.9 1.0 1.1 1.0 -1.2 -0.8 0.5 -0.9 -0.6 -0.8 -0.2 -1.1 -1.0 -0.4
Heart disease (siblings) 1.6 2.0 4.3 1.7 1.9 1.1 1.7 1.3 1.5 1.8 -0.1 2.1 -0.9 -1.1 -1.0 1.5 1.7 -0.7 2.0 -1.2 1.3 0.3 1.5 1.7 0.6
Alcohol drinker status: Previous 1.3 1.5 3.3 1.3 1.0 1.7 1.4 -0.7 1.6 1.2 1.4 1.1 0.6 0.3 0.3 1.3 1.3 0.8 0.7 0.7 1.8 -1.6 1.7 1.6 0.8
Pack years of smoking 1.1 1.6 4.3 1.8 1.0 1.8 1.8 -0.5 1.6 2.1 1.1 1.7 0.6 0.3 0.3 1.3 0.8 0.2 1.6 -1.8 0.3 -0.1 1.3 0.7 1.3
Impedance of whole body 1.0 5.0 11.6 -2.3 -1.9 -3.0 -2.7 2.0 -2.2 -3.2 -3.4 -2.1 -2.8 -2.3 -2.3 -1.2 -0.8 -0.9 -2.0 3.4 0.4 0.8 -1.9 -0.5 -3.1
Leg fat mass (left) 1.2 4.7 13.5 2.3 0.1 3.2 2.7 -2.8 2.1 2.9 3.4 1.7 2.6 2.2 2.3 1.9 1.1 3.7 1.3 -1.9 -1.0 -1.6 1.3 0.1 0.9
Arm predicted mass (left) 0.6 3.2 9.0 1.2 0.2 2.2 1.9 -2.8 1.1 1.8 3.0 0.6 2.9 2.6 2.7 0.1 -0.2 2.3 0.5 -1.9 -1.2 -1.5 0.6 -0.9 1.7