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chr10:95,606,207-98,649,296

Best TWAS P=3.06e-18 · Best GWAS P=1.05e-16 conditioned to 0.00956

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Testis	HELLS	0.08	0.00	enet	27	0.00	3.1e-01	-7.6	-8.7	3.1e-18	0.74	0.05	0.69	TRUE
4	GTEx	Artery Tibial	ZNF518A	0.09	0.03	lasso	3	0.02	4.5e-03	4.9	5.3	1.3e-07	-0.02	0.01	0.85	TRUE
13	ROSMAP	Brain Pre-frontal Cortex	HELLS	0.02	0.01	blup	372	0.00	6.9e-02	-7.5	-8.4	3.9e-17	0.86	0.04	0.93	FALSE
12	METSIM	Adipose	HELLS	0.03	0.04	lasso	3	0.03	9.3e-05	-8.3	-8.2	2.0e-16	0.99	0.03	0.97	FALSE
9	GTEx	Skin Sun Exposed Lower leg	HELLS	0.05	0.02	lasso	3	0.00	1.2e-01	-7.6	-8.2	2.3e-16	0.85	0.09	0.80	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	HELLS	0.03	0.02	blup	47	0.03	2.1e-04	-7.7	-8.2	3.0e-16	0.94	0.03	0.95	FALSE
8	GTEx	Ovary	HELLS	0.15	0.04	lasso	5	0.09	3.1e-03	-8.1	-8.1	6.9e-16	0.90	0.03	0.84	FALSE
7	GTEx	Nerve Tibial	HELLS	0.12	0.12	enet	17	0.10	1.6e-07	-8.3	-7.9	2.7e-15	0.96	0.02	0.98	FALSE
11	GTEx	Thyroid	HELLS	0.07	0.00	enet	8	0.00	2.7e-01	-8.1	-7.9	3.0e-15	0.89	0.03	0.70	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HELLS	0.03	0.03	blup	47	0.03	1.7e-04	-7.2	-7.8	4.5e-15	0.95	0.03	0.96	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	HELLS	0.03	0.03	lasso	3	0.02	5.7e-03	-7.6	-7.8	7.3e-15	0.91	0.03	0.94	FALSE
2	GTEx	Adipose Subcutaneous	HELLS	0.08	0.06	enet	30	0.04	7.0e-04	-8.3	-7.7	1.0e-14	0.84	0.02	0.98	FALSE
15	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TBC1D12	0.04	0.01	blup	63	0.03	8.3e-03	-7.6	7.7	1.3e-14	-0.96	0.02	0.75	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HELLS	0.04	0.04	enet	12	0.04	5.1e-06	-8.3	-7.6	2.3e-14	0.89	0.02	0.98	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	HELLS	0.04	0.01	blup	47	0.03	1.3e-06	-8.3	-7.6	3.1e-14	0.88	0.02	0.98	FALSE
5	GTEx	Brain Cerebellum	HELLS	0.26	0.20	lasso	9	0.19	2.8e-06	-7.5	-7.5	4.3e-14	0.90	0.04	0.95	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	TBC1D12	0.04	0.04	blup	63	0.03	3.9e-04	-8.3	-7.3	2.2e-13	0.95	0.01	0.97	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	HELLS	0.05	0.02	blup	47	0.03	9.6e-04	-7.2	-6.9	5.4e-12	0.86	0.08	0.81	FALSE
3	GTEx	Artery Aorta	CYP2C8	0.21	0.00	lasso	8	0.00	2.2e-01	-5.9	-6.5	6.9e-11	0.33	0.18	0.04	FALSE
6	GTEx	Brain Frontal Cortex BA9	HELLS	0.16	0.09	enet	20	0.15	1.0e-04	-7.2	-5.5	3.9e-08	0.78	0.05	0.92	FALSE