Best TWAS P=3.06e-18 · Best GWAS P=1.05e-16 conditioned to 0.00956
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HELLS | 0.04 | 0.04 | enet | 12 | 0.04 | 5.1e-06 | -8.3 | -7.6 | 2.3e-14 | 0.89 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | HELLS | 0.08 | 0.06 | enet | 30 | 0.04 | 7.0e-04 | -8.3 | -7.7 | 1.0e-14 | 0.84 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Artery Aorta | CYP2C8 | 0.21 | 0.00 | lasso | 8 | 0.00 | 2.2e-01 | -5.9 | -6.5 | 6.9e-11 | 0.33 | 0.18 | 0.04 | FALSE |
| 4 | GTEx | Artery Tibial | ZNF518A | 0.09 | 0.03 | lasso | 3 | 0.02 | 4.5e-03 | 4.9 | 5.3 | 1.3e-07 | -0.02 | 0.01 | 0.85 | TRUE |
| 5 | GTEx | Brain Cerebellum | HELLS | 0.26 | 0.20 | lasso | 9 | 0.19 | 2.8e-06 | -7.5 | -7.5 | 4.3e-14 | 0.90 | 0.04 | 0.95 | FALSE |
| 6 | GTEx | Brain Frontal Cortex BA9 | HELLS | 0.16 | 0.09 | enet | 20 | 0.15 | 1.0e-04 | -7.2 | -5.5 | 3.9e-08 | 0.78 | 0.05 | 0.92 | FALSE |
| 7 | GTEx | Nerve Tibial | HELLS | 0.12 | 0.12 | enet | 17 | 0.10 | 1.6e-07 | -8.3 | -7.9 | 2.7e-15 | 0.96 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Ovary | HELLS | 0.15 | 0.04 | lasso | 5 | 0.09 | 3.1e-03 | -8.1 | -8.1 | 6.9e-16 | 0.90 | 0.03 | 0.84 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | HELLS | 0.05 | 0.02 | lasso | 3 | 0.00 | 1.2e-01 | -7.6 | -8.2 | 2.3e-16 | 0.85 | 0.09 | 0.80 | FALSE |
| 10 | GTEx | Testis | HELLS | 0.08 | 0.00 | enet | 27 | 0.00 | 3.1e-01 | -7.6 | -8.7 | 3.1e-18 | 0.74 | 0.05 | 0.69 | TRUE |
| 11 | GTEx | Thyroid | HELLS | 0.07 | 0.00 | enet | 8 | 0.00 | 2.7e-01 | -8.1 | -7.9 | 3.0e-15 | 0.89 | 0.03 | 0.70 | FALSE |
| 12 | METSIM | Adipose | HELLS | 0.03 | 0.04 | lasso | 3 | 0.03 | 9.3e-05 | -8.3 | -8.2 | 2.0e-16 | 0.99 | 0.03 | 0.97 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | HELLS | 0.02 | 0.01 | blup | 372 | 0.00 | 6.9e-02 | -7.5 | -8.4 | 3.9e-17 | 0.86 | 0.04 | 0.93 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HELLS | 0.04 | 0.01 | blup | 47 | 0.03 | 1.3e-06 | -8.3 | -7.6 | 3.1e-14 | 0.88 | 0.02 | 0.98 | FALSE |
| 15 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TBC1D12 | 0.04 | 0.01 | blup | 63 | 0.03 | 8.3e-03 | -7.6 | 7.7 | 1.3e-14 | -0.96 | 0.02 | 0.75 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HELLS | 0.03 | 0.03 | blup | 47 | 0.03 | 1.7e-04 | -7.2 | -7.8 | 4.5e-15 | 0.95 | 0.03 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HELLS | 0.03 | 0.03 | lasso | 3 | 0.02 | 5.7e-03 | -7.6 | -7.8 | 7.3e-15 | 0.91 | 0.03 | 0.94 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HELLS | 0.03 | 0.02 | blup | 47 | 0.03 | 2.1e-04 | -7.7 | -8.2 | 3.0e-16 | 0.94 | 0.03 | 0.95 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBC1D12 | 0.04 | 0.04 | blup | 63 | 0.03 | 3.9e-04 | -8.3 | -7.3 | 2.2e-13 | 0.95 | 0.01 | 0.97 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | HELLS | 0.05 | 0.02 | blup | 47 | 0.03 | 9.6e-04 | -7.2 | -6.9 | 5.4e-12 | 0.86 | 0.08 | 0.81 | FALSE |