Hub : Genes

TSPAN32

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.5717	0.0527	9.7e-15	0.122	NA	0.290	NA	0.328	6.4e-09	NA	8.1e-21	NA	7.3e-24
2	GTEx	Spleen	0.5700	0.1530	6.2e-03	0.025	NA	0.130	NA	0.022	7.7e-02	NA	3.4e-04	NA	9.0e-02
3	GTEx	Stomach	0.3760	0.0980	2.1e-03	-0.006	NA	-0.006	NA	-0.006	8.0e-01	NA	8.9e-01	NA	8.1e-01
4	YFS	Blood	0.2918	0.0284	0.0e+00	0.197	0.225	0.242	0.26	0.228	3.7e-62	4.8e-72	4.0e-78	1.1e-84	3.7e-73
5	TCGA	Breast Invasive Carcinoma	0.0435	0.0198	4.7e-05	0.028	0.022	0.022	NA	0.023	1.8e-06	2.2e-05	1.6e-05	NA	1.5e-05
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0961	0.0408	5.4e-07	0.044	0.075	0.080	NA	0.074	9.1e-06	8.4e-09	2.8e-09	NA	1.0e-08
7	TCGA	Brain Lower Grade Glioma	0.0259	0.0148	3.9e-03	0.013	0.013	0.004	NA	0.004	1.1e-02	1.1e-02	1.1e-01	NA	1.0e-01
8	TCGA	Lung Adenocarcinoma	0.0720	0.0275	4.6e-06	0.015	0.044	0.046	NA	0.028	6.0e-03	6.2e-06	3.6e-06	NA	2.6e-04
9	TCGA	Lung Squamous Cell Carcinoma	0.0399	0.0220	4.8e-03	0.036	0.013	0.014	NA	0.024	5.1e-05	1.1e-02	9.2e-03	NA	8.4e-04
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.1870	0.0750	1.1e-05	0.107	0.050	0.074	NA	0.076	1.1e-07	2.8e-04	1.1e-05	NA	7.4e-06
11	TCGA	Thyroid Carcinoma	0.0460	0.0250	5.5e-03	-0.003	0.017	0.006	NA	0.004	7.8e-01	8.5e-03	7.8e-02	NA	1.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.8	3.3	0.2	0.7	1.8	0.2	0.0	1.3	-1.1	1.5	0.0	0.0	0.1
Bipolar Disorder or Schizophrenia	0.8	1.9	6.7	1.1	1.5	1.5	0.2	0.0	2.6	-1.4	2.6	0.0	0.0	0.7
Depressed Affect (Nagel 2018)	0.6	1.3	4.4	0.5	-0.7	1.1	0.6	-1.5	-0.7	-0.7	-0.1	-1.7	-1.3	-2.1
Depression (Nagel 2018)	0.6	0.9	3.0	0.7	-1.7	1.5	-0.6	-0.9	0.2	-0.4	1.4	-0.7	0.1	-0.3
Intelligence (Savage-Jansen 2018)	1.0	3.2	11.4	-1.6	1.6	-1.4	1.8	-1.3	-2.0	-0.5	-1.8	-1.3	-1.7	-3.4
Neuroticism (Nagel 2018)	0.2	0.4	2.1	1.4	-0.1	0.6	-0.1	-0.1	0.1	-0.4	1.2	-0.1	0.3	-0.4
Schizophrenia (2018)	0.5	1.0	4.0	0.8	1.4	0.6	0.4	0.0	1.8	-0.8	2.0	0.0	0.0	0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.0	0.0	-1.1	0.9	0.0	-0.7	0.6	-1.0	0.0	0.0	-1.0
Worry (Nagel 2018)	0.6	1.3	4.3	2.1	-0.4	0.2	-0.5	0.8	1.2	-0.3	2.0	1.0	1.2	0.9
Alzheimer’s Disease (in mother)	0.3	0.4	1.9	-0.1	-0.1	0.3	0.4	-0.1	0.8	-0.1	0.9	-0.4	-0.2	1.4
Alzheimer’s Disease (in father)	0.4	0.4	1.1	0.2	0.5	0.3	0.0	1.0	0.8	-0.3	0.6	0.9	0.9	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	1.8	-0.2	0.2	0.4	0.4	0.4	0.9	-0.2	0.8	-0.3	-0.1	1.4
Crohns Disease (2017)	2.0	4.5	12.5	3.5	0.7	-0.4	-1.2	2.3	2.2	-0.7	3.2	2.6	2.7	-0.0
Irritable Bowel Disease (IBD)	2.0	4.8	13.4	3.7	-0.1	-1.6	-2.4	2.2	1.6	0.1	2.9	2.7	2.7	0.7
Ulcerative Colitis (UC)	1.6	3.0	7.4	2.6	-1.2	-1.7	-2.7	1.3	0.4	0.9	1.9	1.9	1.8	1.3
Major Depression (MDD)	0.1	0.1	0.9	0.0	0.0	0.0	0.0	0.0	0.0	0.9	-0.8	0.0	0.0	-0.2
Reaction Time	0.5	1.0	2.8	0.5	-0.2	1.2	-1.7	1.2	0.0	0.4	0.1	1.1	1.5	1.3
Verbal and Numeric Reasoning (VNR)	1.9	4.5	16.8	-2.2	2.4	-1.2	2.7	-0.6	-1.3	-1.3	-2.5	-1.0	-1.2	-4.1
Breast Cancer	1.1	2.6	6.6	-2.6	-2.1	-1.6	0.0	-1.9	-0.9	1.0	-2.2	-1.5	-1.5	0.5
Ovarian Cancer	2.4	3.2	7.7	-0.4	-2.0	-0.3	-1.9	-1.7	-2.0	2.8	-2.1	-1.9	-1.8	1.1
Prostate Cancer	2.1	2.9	10.1	-1.4	0.5	-0.4	1.6	-1.4	-1.9	-0.4	-2.3	-1.5	-2.0	-3.2
Age at First Birth	0.5	0.8	5.7	-0.4	0.8	-2.4	-0.2	0.0	0.3	0.4	-1.3	0.0	-0.3	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	2.0	10.8	-1.2	0.9	0.6	1.6	-0.3	-0.5	-2.2	-0.7	-0.5	-0.3	-3.3
Coronary Artery Disease (CAD)	1.8	2.1	8.9	0.0	0.0	0.0	-1.4	0.0	-3.0	2.2	-2.7	0.0	0.0	0.4
Crohns Disease (2012)	1.2	2.0	8.4	2.9	0.8	-0.2	-0.2	1.7	1.7	-0.4	2.0	0.0	1.6	-0.0
Mean Putamen Volume	1.3	1.4	3.6	0.8	1.6	0.8	0.5	1.3	1.8	-1.9	0.1	0.9	0.9	-1.4
Fasting Glucose	0.2	0.2	0.8	0.0	-0.9	0.5	-0.3	-0.7	0.2	0.1	0.5	-0.3	-0.2	0.5
HbA1C	1.4	1.6	5.4	-1.1	-1.2	-0.1	-0.8	-1.5	-2.3	1.8	-0.9	-0.6	-0.9	1.0
HDL Cholesterol	0.5	0.8	2.1	-1.0	1.2	-0.4	1.4	0.1	-0.5	-1.2	-0.3	-0.5	-0.2	-1.3
LDL Cholesterol	0.4	0.7	2.3	-1.1	-0.7	1.5	0.2	-0.8	-0.4	-0.9	-0.3	-0.2	-0.4	-1.3
Lupus	1.0	1.6	4.6	-0.7	-1.5	1.3	0.8	-2.1	-0.1	-0.7	-0.4	-1.7	-1.5	-1.3
Neuroticism (2016)	0.9	1.3	4.6	1.8	1.2	1.1	0.1	1.0	0.9	-0.7	2.2	0.6	0.9	-0.8
Primary Biliary Cirrhosis	0.6	0.9	2.5	0.5	-1.6	1.1	-1.5	-0.7	-1.0	1.2	-0.5	-0.4	-0.5	-0.3
Rheumatoid Arthritis	0.4	0.5	2.3	-0.7	-1.4	1.5	-0.5	0.0	-0.6	0.4	-0.1	0.0	0.0	0.5
Schizophrenia (2014)	0.4	0.9	2.6	0.8	1.0	1.3	0.8	0.0	1.6	-1.2	1.4	0.0	0.0	-0.6
Triglycerides	0.4	0.6	1.6	0.7	-0.4	1.0	-1.0	0.5	0.5	0.8	0.5	0.8	0.8	1.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.3	0.0	0.9	1.2	-0.4	0.0	-1.5	1.5	-1.0	0.0	0.0	0.9
Ulcerative Colitis	0.5	0.7	3.0	0.4	-1.0	-1.7	-0.5	0.0	-1.1	0.4	-0.9	0.0	0.0	-0.8
Blood Eosinophil Count	0.4	3.1	12.1	2.7	-3.5	1.2	-2.3	-1.8	0.2	1.5	0.6	-1.1	-1.0	0.8
Blood Platelet Count	0.1	1.1	3.6	1.9	-0.6	-1.1	-1.4	-0.5	-0.9	1.3	0.6	-0.3	0.2	-1.1
Blood Red Count	1.3	12.7	47.6	0.8	-6.9	-0.1	-3.1	-5.4	-2.4	3.7	-1.8	-4.0	-3.9	-0.1
Blood White Count	0.6	4.4	13.3	3.6	-2.6	0.6	-3.2	-0.4	-0.0	2.5	2.8	0.7	0.5	1.5
Heel T-Score	0.3	2.4	6.2	-1.2	-2.5	-1.1	-1.5	-1.8	-1.3	1.8	-2.1	-1.1	-1.2	0.7
BMI	0.4	2.4	5.6	-0.3	-0.4	-0.5	0.6	-2.0	-1.9	0.5	-1.4	-2.3	-2.4	-2.0
Height	0.3	5.2	11.8	-1.9	0.3	3.4	3.3	-2.0	-0.4	-2.5	-1.4	-2.2	-1.7	-3.3
Waist Hip Ratio (WHR)	0.5	2.1	4.4	-1.2	-0.7	1.5	0.8	-2.1	-1.4	0.4	-1.7	-1.9	-2.0	-1.1
Systolic Blood Pressure	0.4	2.2	6.1	0.4	-2.0	-1.5	-1.7	-1.2	-0.9	2.2	0.3	-0.8	-0.9	2.5
Smoking Status	0.2	0.5	2.7	0.1	1.6	-0.4	1.0	-0.4	0.2	-0.2	0.4	-0.8	-0.6	-0.0
Allergy or Eczema	1.9	5.1	13.8	0.9	1.5	-0.4	0.4	2.6	2.1	-3.7	1.4	2.7	3.3	-2.7
Cardiovascular Disease	0.2	0.6	3.7	0.6	-1.2	0.5	-1.9	-0.5	-0.2	0.6	0.1	-0.3	0.0	0.2
Hypothyroidism (self reported)	2.8	6.4	13.4	-1.8	-0.8	2.6	1.6	-3.4	-2.2	-0.3	-2.2	-3.7	-3.6	-2.9
Respiratory disease	0.7	1.5	7.3	-0.2	-0.8	-0.1	1.0	-0.8	1.1	-1.9	-0.1	-1.1	-0.8	-2.7
Type 2 Diabetes (T2D) (2018)	2.7	5.1	12.3	-1.0	-2.5	1.5	-2.4	-1.9	-3.2	3.5	-1.9	-1.5	-1.9	2.5
Lung FEV1/FVC ratio	0.1	0.5	1.7	-0.5	-0.0	-0.8	-0.9	0.0	-1.0	1.3	-0.9	-0.0	-0.6	-0.3
Lung FVC	0.3	1.7	9.9	-0.3	3.1	-0.0	1.6	0.3	-0.5	-1.0	-1.1	-0.3	-0.2	-1.9
Neuroticism	0.2	0.4	2.1	1.5	-0.3	0.2	-0.6	-0.0	0.1	0.0	1.1	0.1	0.2	-0.5
Chronotype (morning person)	0.2	0.4	2.9	-1.7	-0.3	0.1	0.2	0.1	-0.5	-0.5	-0.9	0.4	0.5	-0.3
Hair Pigment	0.3	7.4	23.0	2.9	-2.0	-1.2	-3.1	1.8	2.1	2.0	3.1	2.6	2.6	4.8
Tanning	0.1	0.8	1.5	-1.1	0.2	-0.1	1.0	-0.8	-1.0	-0.8	-0.9	-1.0	-0.9	-1.2
Hand grip strength (left)	1.2	3.0	6.0	-0.9	-1.4	-2.4	0.5	-1.9	-1.8	0.7	-2.3	-1.8	-2.1	-2.1
Number of treatments/medications taken	0.8	1.5	5.8	0.2	-2.4	-0.0	-0.7	-2.0	0.3	-0.3	0.2	-1.7	-1.3	-0.9
Average weekly spirits intake	0.3	0.4	1.6	0.2	0.6	0.5	0.6	0.1	0.6	-1.3	0.2	-0.0	0.2	-1.0
Sensitivity / hurt feelings	0.5	0.8	2.8	1.7	0.6	1.2	0.3	0.3	0.0	-0.9	1.5	0.1	0.1	-1.3
Frequency of depressed mood in last 2 weeks	0.5	0.6	2.7	0.6	-1.6	1.0	-0.7	-0.8	0.1	-0.2	1.2	-0.5	0.1	-0.2
Hearing difficulty/problems: Yes	0.6	0.9	2.6	-0.7	-0.5	1.0	-0.1	-1.2	-0.8	0.6	-0.8	-1.6	-1.3	-0.3
Relative age of first facial hair	1.2	2.5	9.1	-0.6	-1.4	-3.0	-0.2	-1.4	-1.3	2.4	-0.7	-1.1	-1.5	1.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.4	-1.6	-0.6	-1.0	0.1	-1.1	-0.3	0.3	-1.3	-1.0	-1.0	-0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	-0.7	-0.3	-0.9	-0.6	0.3	-0.2	0.6	-0.4	0.3	0.1	1.0
Ever had hysterectomy (womb removed)	1.1	1.2	2.5	1.2	0.1	1.5	-1.4	1.5	0.4	0.2	0.7	1.6	1.5	0.2
Systolic blood pressure, automated reading	0.9	2.6	5.7	-0.1	-2.2	-1.2	-1.6	-1.5	-0.9	2.3	-0.7	-1.4	-1.6	2.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.5	0.3	0.2	1.1	-0.1	-0.2	0.2	0.5	0.1	-0.2	-0.3	1.2
Angina	0.7	0.9	3.3	-0.4	-0.4	-0.2	0.7	-1.8	-0.8	0.1	-0.3	-1.6	-1.3	-1.2
Medication for hormone replacement therapy	1.0	1.1	2.5	-0.2	1.0	-1.1	0.4	1.3	0.9	-1.1	0.9	1.6	1.6	0.4
Vitamin and mineral supplements	0.3	0.4	1.2	-0.3	0.3	-0.1	1.1	-0.3	1.1	-0.7	-0.1	-0.7	-0.8	-0.2
Supplements: Zinc	0.6	0.6	1.4	-0.7	-0.6	-0.9	-0.2	-0.9	-0.7	0.1	-1.2	-0.8	-0.7	-1.0
Medication: Co-codamol	0.5	0.6	4.2	0.2	0.1	0.9	0.4	-0.6	-0.0	-0.4	-0.1	-0.6	-0.9	-2.1
Medication: Metformin	4.2	5.9	12.0	-1.7	-3.1	1.6	-2.5	-2.2	-2.7	3.5	-2.0	-1.8	-2.1	2.6
Diabetes (father)	0.9	1.2	2.9	0.3	1.2	1.1	-1.0	1.7	-0.0	0.6	0.3	1.3	1.4	1.5
Diabetes (mother)	0.8	1.1	3.3	1.0	-0.4	1.4	-1.8	0.2	-0.9	1.5	0.2	0.4	-0.0	1.4
Severe depression (siblings)	0.5	0.5	2.1	-0.9	-0.6	1.5	-0.9	0.1	0.1	-0.8	-0.1	0.3	0.7	-0.4
Pack years adult smoking proportion	0.2	0.3	1.0	0.1	-0.8	0.3	-1.0	-0.2	-0.6	0.4	-0.5	0.1	0.3	-0.5
Impedance of leg (right)	0.4	2.0	7.4	0.1	0.1	2.1	0.9	0.8	2.7	-1.5	1.3	1.2	1.5	1.1
Leg fat-free mass (left)	0.8	4.1	10.4	-1.0	-0.4	-0.3	1.6	-2.5	-2.6	-0.4	-1.8	-2.6	-2.8	-3.2
Trunk fat percentage	0.3	1.4	5.0	0.5	0.5	2.2	1.6	-0.1	1.2	-1.9	0.0	-0.2	-0.0	-1.4
Hand grip strength (right)	0.7	1.9	6.5	-0.2	-1.0	-2.1	0.5	-1.3	-1.3	-0.2	-1.2	-1.0	-1.4	-2.5
Townsend deprivation index at recruitment	1.3	1.8	7.8	1.1	-2.5	0.2	-2.8	-0.5	-0.5	1.8	0.3	0.1	0.4	1.0
Current tobacco smoking	0.4	0.6	1.5	-1.2	0.2	0.4	0.6	-1.1	-1.0	0.5	-0.8	-1.0	-0.9	0.0
Average weekly fortified wine intake	1.2	1.4	3.8	-1.7	0.4	-1.5	-0.5	-0.1	-2.0	1.4	-1.9	-0.3	-0.7	-0.2
Maternal smoking around birth	0.4	0.5	2.1	-1.0	0.1	0.7	-0.8	0.1	-1.4	0.7	-0.9	0.1	-0.2	0.2
Fed-up feelings	1.7	3.0	8.6	-0.3	-1.8	1.3	0.3	-2.9	-1.6	0.3	-0.7	-2.7	-2.5	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.2	-0.0	-1.1	0.6	-0.2	-1.8	-1.2	0.3	0.6	-1.3	-0.8	-0.5
Relative age voice broke	0.5	0.8	2.3	0.5	-1.5	-1.0	-1.0	-0.2	-0.7	1.4	0.4	0.1	-0.1	1.2
Taking other prescription medications	0.6	1.0	3.1	-0.3	-1.8	1.5	-0.4	-1.6	0.2	0.2	0.0	-1.4	-0.9	-0.2
Age when periods started (menarche)	0.6	1.5	5.3	-0.5	-0.9	2.3	1.1	-1.5	0.4	-0.6	-0.5	-1.6	-1.8	-0.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.0	-0.4	0.2	0.4	-0.7	1.2	0.1	0.6	0.2	1.6	1.7	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	1.0	-0.4	0.1	-1.0	0.7	-0.4	-0.2	-0.3	-0.3	0.2	0.0	-0.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.9	-0.0	0.5	-0.7	-0.4	0.3	-0.4	0.9	-0.7	-0.0	-0.0	0.1
Qualifications: CSEs or equivalent	1.5	2.0	8.1	-2.8	0.3	-0.3	1.3	-1.4	-1.6	-0.3	-1.8	-1.5	-1.3	-0.9
Serious illness, injury or assault to yourself	0.6	0.8	2.3	-0.3	-1.0	1.5	-0.2	-1.2	-0.1	-0.5	-0.5	-1.3	-0.9	-0.9
High blood pressure	0.6	1.6	5.8	1.6	-0.8	1.0	-1.3	0.4	2.4	-0.8	1.6	0.6	1.1	0.6
Hayfever, allergic rhinitis or eczema	1.4	3.0	8.4	0.8	0.5	-0.7	-0.0	1.8	1.6	-2.9	1.0	2.0	2.7	-2.4
Multivitamins +/- minerals	0.5	0.6	1.7	0.5	-0.5	0.9	-1.3	0.2	-0.7	1.1	0.5	0.5	0.5	1.0
Stomach or abdominal pain in last month	1.0	1.2	4.6	-0.2	0.3	0.3	1.1	-1.4	0.3	-1.3	-0.2	-1.6	-0.9	-2.2
Supplements: Glucosamine	0.1	0.1	0.3	-0.1	0.5	-0.5	0.3	0.3	-0.0	-0.4	-0.4	0.5	0.4	-0.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.0	0.3	0.5	-0.4	-1.4	1.7	1.1	0.3	0.1	1.6	1.7	1.4
Medication: Atenolol	0.5	0.6	1.4	0.6	-1.0	0.3	-0.3	-0.9	0.4	-0.5	1.2	-0.9	-0.7	-0.8
Medication: Levothyroxine sodium	1.8	3.1	8.2	-1.3	-1.3	2.9	0.6	-2.6	-1.3	0.1	-1.1	-2.5	-2.2	-1.3
Sitting height	0.7	4.7	16.7	-1.5	1.3	0.9	3.7	-1.4	0.4	-3.3	-0.4	-1.4	-1.3	-4.1
Chronic bronchitis/emphysema (father)	1.2	1.4	9.1	0.2	-0.4	3.0	-0.5	-0.5	-0.2	0.7	1.0	-0.7	-0.4	1.9
High blood pressure (mother)	0.5	0.7	4.4	-0.3	0.4	-2.1	0.2	-0.6	-1.0	-0.1	0.1	-0.7	-0.6	-1.0
Body mass index (BMI)	0.2	0.7	1.9	0.3	-0.3	-0.3	0.4	-1.1	-0.6	-0.1	-0.7	-1.4	-1.3	-1.3
Impedance of leg (left)	0.4	1.9	6.8	-0.1	0.1	2.3	0.9	0.7	2.6	-1.3	1.0	1.0	1.4	1.4
Leg predicted mass (left)	0.8	4.0	10.1	-0.9	-0.4	-0.3	1.5	-2.5	-2.5	-0.4	-1.7	-2.6	-2.8	-3.2
Trunk fat mass	0.3	1.3	3.7	0.1	0.1	1.6	1.6	-0.9	0.3	-1.6	-0.6	-1.0	-0.9	-1.9
Waist circumference	0.6	2.2	5.7	-0.3	-0.2	0.9	1.5	-1.8	-0.8	-0.9	-1.1	-2.2	-2.1	-2.4
Number of incorrect matches in round	0.4	0.7	1.7	0.6	0.3	0.4	-0.9	1.3	0.7	0.5	0.3	1.3	1.0	0.9
Past tobacco smoking	0.4	0.7	2.4	-1.5	0.1	-0.8	0.8	-0.3	-0.5	-0.3	-1.6	-0.1	-0.5	-1.1
Alcohol usually taken with meals	0.9	1.4	4.4	0.2	1.8	-2.1	0.1	1.9	0.8	0.1	0.1	1.6	1.2	0.3
Nervous feelings	0.4	0.7	2.3	0.7	-0.6	0.8	-0.5	0.5	0.9	0.1	1.5	0.7	0.7	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	5.7	0.2	-0.7	2.4	0.2	-1.1	0.3	-0.7	0.3	-0.8	-0.4	-0.8
Hearing difficulty/problems with background noise	0.4	0.7	4.8	0.0	0.9	2.2	0.3	0.6	0.7	-0.7	0.2	0.4	0.7	-0.7
Hair/balding pattern: Pattern 2	0.2	0.3	2.2	-0.3	-0.2	-1.5	-0.4	0.4	-0.2	-0.1	-0.2	0.2	0.0	0.3
Had menopause	0.1	0.2	0.8	-0.6	0.3	0.1	-0.2	-0.1	0.2	0.4	-0.9	-0.3	-0.2	0.3
Had other major operations	1.6	2.0	5.7	-1.1	-2.4	1.8	-1.2	-1.6	-1.3	1.4	-0.6	-1.4	-1.1	0.5
Forced vital capacity (FVC)	1.0	4.0	15.5	-0.9	2.1	1.5	2.9	-1.0	-1.2	-2.3	-0.8	-1.4	-1.2	-3.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	-0.5	0.3	-0.2	0.9	-0.1	0.1	-0.8	0.0	0.5	0.4	-0.8
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	5.6	2.1	-0.7	2.4	-1.2	1.4	1.7	-0.4	2.1	1.6	2.0	1.0
Qualifications: None of the above	1.1	2.4	8.1	1.3	-2.8	1.9	-2.4	-0.7	-0.3	1.8	0.4	-0.2	-0.2	1.7
Financial difficulties in last 2 years	1.1	1.5	3.6	-1.0	-1.0	0.1	0.6	-1.9	-1.5	0.1	-0.8	-1.7	-1.7	-1.4
Mouth/teeth dental problems	0.2	0.2	1.9	-0.1	-0.4	1.4	0.6	0.0	0.2	-0.5	0.3	-0.0	0.0	0.1
Heart attack	1.2	1.6	4.8	-0.9	-2.2	0.9	-0.3	-2.2	-0.9	0.5	-0.5	-1.8	-1.2	0.1
Allergy	0.9	2.0	7.5	-0.4	0.0	-0.8	-0.1	-1.0	-1.2	2.7	-0.7	-0.9	-1.7	2.7
Pain all over the body in last month	0.3	0.3	0.9	0.3	-0.3	-0.3	-0.2	-0.8	-1.0	0.8	-0.3	-0.8	-0.6	-0.3
Diabetes (self-reported)	2.0	3.0	6.4	-1.4	-1.6	1.5	-1.4	-1.8	-2.5	2.3	-1.6	-1.6	-1.7	1.4
Hayfever/allergic rhinitis (self-reported)	3.6	4.7	9.5	0.4	1.8	-1.6	1.0	2.8	2.8	-3.1	1.1	2.7	2.9	-1.7
Medication: Ramipril	2.5	3.2	6.3	2.5	-0.9	0.9	-2.0	1.2	1.9	0.7	2.4	1.7	1.9	2.4
Medication: Simvastatin	0.2	0.3	1.6	0.8	-0.1	0.4	-0.3	-0.0	0.2	-0.3	0.7	0.0	-0.2	-1.3
Fluid intelligence score	1.3	2.7	6.5	-2.0	1.2	-0.6	2.1	-1.3	-1.1	-0.5	-2.3	-1.5	-1.5	-2.6
Illnesses of siblings	0.4	0.6	1.8	-0.4	0.8	-1.3	1.2	-0.4	-0.3	-0.3	-0.8	-0.6	-0.8	-0.5
Neuroticism score	0.4	0.9	3.2	1.1	-0.4	1.8	0.1	-0.5	-0.2	-0.9	1.3	-0.5	-0.2	-1.5
Weight	0.6	2.7	7.6	-0.5	-0.4	0.6	1.7	-2.1	-1.1	-1.0	-1.4	-2.3	-2.2	-2.8
Impedance of arm (right)	1.7	8.0	15.8	2.0	1.8	3.9	1.0	2.9	4.0	-2.9	3.2	3.2	3.5	0.5
Arm fat percentage (right)	0.3	1.3	3.4	1.2	1.1	1.5	1.4	0.2	1.0	-1.8	0.8	-0.1	0.1	-1.7
Trunk fat-free mass	1.0	5.8	13.0	-1.5	-1.0	-1.0	1.3	-3.3	-3.2	0.4	-2.1	-3.4	-3.6	-2.8
Hip circumference	0.4	1.7	5.2	0.1	0.9	0.9	2.3	-0.5	0.6	-2.2	-0.0	-0.9	-0.9	-2.2
Time employed in main current job	1.5	1.7	4.7	-0.4	-1.9	-0.1	-1.1	-1.5	-0.5	2.2	-1.0	-1.2	-1.2	1.8
Alcohol intake versus 10 years previously	1.1	1.6	4.5	-0.8	-0.6	-0.1	-0.1	-1.8	-2.1	1.9	-1.0	-1.5	-1.6	0.6
Father’s age at death	0.2	0.3	1.1	-0.4	0.1	0.6	-0.4	0.7	0.1	-0.4	-1.0	0.6	0.7	-0.6
Worrier / anxious feelings	0.9	1.6	4.3	2.1	0.2	-0.6	-1.2	1.6	0.5	0.2	2.1	1.5	1.4	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.5	-1.1	-0.6	1.9	1.1	-1.2	-0.4	-0.4	-0.2	-1.1	-0.9	-1.2
Falls in the last year	0.3	0.4	1.7	0.3	0.3	0.5	0.3	0.5	0.5	-1.0	0.4	0.5	0.6	-1.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.2	-1.1	0.8	0.5	0.5	-0.6	-0.8	0.4	-0.6	-0.6	-0.7	0.3
Number of live births	0.4	0.6	2.7	0.3	-1.3	0.3	-1.6	0.6	0.4	0.2	-0.5	0.7	0.8	-0.4
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	16.1	-1.0	2.5	0.6	3.1	-0.7	-0.9	-2.4	-0.9	-1.1	-1.1	-4.0
Pulse rate	0.5	0.8	3.4	-0.0	-0.4	-1.4	-0.3	-0.8	-1.8	0.6	-0.9	-0.5	-0.5	-0.9
Happiness	0.4	0.5	1.4	-0.3	-0.7	0.6	0.6	-1.1	0.0	-0.4	0.5	-1.2	-0.9	-0.2
Noisy workplace	0.5	0.6	1.6	0.2	-0.7	0.4	-1.3	0.6	-0.6	0.7	1.0	0.7	0.8	1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.0	0.5	1.7	-1.1	0.5	1.5	0.9	-0.4	0.2	1.2	0.8	0.3
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.2	8.9	-1.9	1.0	0.6	1.5	-1.1	-1.1	-1.2	-1.3	-1.4	-1.0	-3.0
Mouth/teeth dental problems: Dentures	1.0	1.7	12.0	0.2	1.2	0.9	1.1	-0.2	-0.6	-1.7	-0.2	-0.3	-0.3	-3.5
Asthma	0.5	1.0	5.1	0.0	-0.1	1.3	0.9	-0.2	0.6	-1.6	-0.1	-0.5	-0.3	-2.2
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	8.2	-0.9	-1.2	0.3	1.4	-2.7	-1.0	-0.3	-1.0	-2.9	-2.6	-1.2
Medication: Cholesterol lowering	0.7	1.1	3.6	0.4	-1.9	1.6	-1.5	-0.9	-0.6	1.1	-0.1	-0.6	-0.3	0.5
Depression (self-reported)	0.2	0.2	1.1	0.7	-1.0	0.6	-0.4	-0.4	0.2	0.2	0.3	-0.3	-0.0	0.1
Medication: Lansoprazole	0.4	0.5	1.2	0.1	-0.9	0.8	-0.0	-1.1	-0.4	0.1	0.4	-0.8	-0.6	-1.1
Prospective memory result	0.5	0.6	1.8	-0.7	-1.4	-0.9	-0.4	-0.5	-1.0	0.0	-1.1	-0.2	-0.2	-0.9
Lung cancer (father)	0.3	0.3	1.5	0.4	-0.6	-0.5	-0.6	0.2	0.1	0.9	0.3	-0.0	-0.3	1.2
Illnesses of mother	1.4	1.8	4.9	2.2	0.8	1.5	-1.0	1.8	1.4	0.1	0.9	1.7	1.6	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	17.2	-1.3	2.7	0.2	2.9	-0.7	-0.8	-2.2	-1.2	-1.3	-1.3	-4.2
Pulse wave Arterial Stiffness index	0.4	0.4	1.7	-0.1	-0.5	0.8	0.1	-0.6	-0.0	-0.8	0.4	-0.8	-0.4	-1.3
Impedance of arm (left)	1.2	5.8	11.6	1.6	1.1	3.2	0.4	2.5	3.4	-2.4	2.5	2.9	3.3	0.4
Arm fat mass (right)	0.3	1.3	5.5	0.8	0.7	1.0	1.6	-0.7	0.2	-1.7	0.0	-0.9	-0.8	-2.3
Trunk predicted mass	1.0	5.8	13.0	-1.4	-1.0	-1.1	1.3	-3.3	-3.2	0.4	-2.1	-3.4	-3.6	-2.8
Standing height	0.4	3.6	8.6	-1.4	-0.3	1.9	2.8	-2.1	-0.9	-1.7	-1.3	-1.9	-1.9	-2.9
Length of working week for main job	1.6	1.8	3.5	-1.1	-1.6	-1.4	-1.1	-1.1	-1.9	1.5	-1.6	-0.9	-1.1	0.9
Exposure to tobacco smoke at home	0.8	0.9	3.0	-0.2	-1.7	1.1	-1.4	-0.7	-0.4	0.6	-1.3	-0.3	-0.2	-0.6
Breastfed as a baby	0.9	1.2	2.4	1.1	-0.1	-1.3	-0.5	1.5	1.6	0.2	0.5	1.4	1.1	1.1
Tense / ‘highly strung’	0.4	0.7	3.0	1.4	0.4	0.7	-0.2	0.7	0.7	-0.4	1.7	0.7	0.8	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.5	-0.7	-0.5	-0.7	-0.7	-1.1	0.4	-0.1	-0.3	0.1	-1.0
Hair/balding pattern: Pattern 4	1.5	3.7	7.2	2.3	-0.0	0.4	-1.2	2.3	2.0	-0.4	2.7	2.5	2.7	1.8
Birth weight of first child	1.7	3.2	6.1	-1.3	-0.6	-2.3	0.4	-2.2	-2.2	1.4	-1.9	-2.5	-2.4	-0.3
Peak expiratory flow (PEF)	1.1	2.4	7.0	-1.1	1.8	0.2	2.5	-1.1	-1.0	-1.5	-0.5	-1.6	-1.4	-2.6
Pulse wave reflection index	1.1	1.4	2.5	1.1	0.2	1.4	-0.7	1.4	1.5	-1.0	1.4	1.3	1.6	-0.7
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.8	1.6	1.2	0.2	0.6	1.3	1.5	-1.2	1.7	1.2	1.0	-0.3
Loud music exposure frequency	0.4	0.4	1.5	-0.1	1.2	-0.3	1.0	0.3	0.0	-0.8	-0.4	0.1	0.2	-1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.4	-0.8	1.0	-1.2	0.9	0.7	0.1	-1.0	-0.8	0.3	0.4	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	4.1	0.5	-0.1	-0.5	-0.7	0.6	0.8	0.8	0.7	0.5	0.5	2.0
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.7	-0.7	0.5	-0.6	0.1	0.1	-0.1	0.5	0.0	0.1	-0.0
Medication: Paracetamol	0.3	0.5	2.5	0.1	-1.0	1.6	0.1	-0.9	-0.2	-0.4	0.3	-0.8	-0.6	-0.6
Headache pain in last month	0.5	0.8	1.6	0.7	-1.2	0.4	0.6	-1.3	0.2	-0.9	0.7	-1.2	-0.8	-1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.8	-0.4	1.7	-1.0	1.3	0.9	0.4	-1.2	0.1	0.5	0.1	-1.2
Glaucoma (self-reported)	1.8	2.1	5.5	1.3	2.3	-2.0	0.5	1.8	1.3	-0.2	1.5	1.4	1.1	1.2
Gout (self-reported)	0.3	0.4	2.3	0.2	-0.1	-1.1	0.0	0.0	0.3	0.4	0.4	0.2	0.2	1.5
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	10.9	-1.0	-0.8	2.4	1.1	-3.1	-1.5	-0.2	-1.6	-3.3	-3.2	-2.7
Medication: Amlodipine	0.3	0.4	1.9	0.6	-0.5	0.0	-0.6	-0.2	0.3	0.6	0.8	0.1	0.2	1.4
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	-0.1	-0.6	-0.4	-0.1	-0.3	-0.5	0.3	-0.8	-0.3	-0.5	-0.8
Birth weight	5.0	10.8	26.5	-2.3	1.1	-3.1	3.1	-3.1	-2.8	-1.1	-3.9	-4.0	-4.1	-5.2
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.9	-1.1	-1.4	0.7	0.6	-0.2	0.5	-0.8	0.1	-0.0	0.2	0.9
High blood pressure (siblings)	0.3	0.4	1.0	-0.8	-0.9	-0.4	0.1	-1.0	-0.1	-0.3	-0.3	-0.8	-0.7	-0.8
Forced vital capacity (FVC), Best measure	1.4	5.1	20.5	-1.5	2.5	0.7	3.2	-1.1	-1.0	-2.6	-1.4	-1.7	-1.5	-4.5
Body fat percentage	0.2	1.0	3.5	0.4	0.4	1.9	1.4	-0.3	0.9	-1.6	-0.1	-0.5	-0.2	-1.2
Leg fat percentage (right)	0.2	0.7	1.3	-0.1	-0.3	1.1	1.0	-1.0	0.4	-1.1	-0.6	-1.1	-0.8	-1.0
Arm fat-free mass (right)	1.6	8.0	17.0	-2.4	-1.2	-1.5	1.4	-3.8	-3.6	0.6	-3.1	-3.9	-4.1	-2.7
Exposure to tobacco smoke outside home	0.9	1.3	4.0	0.7	-1.5	2.0	-1.2	0.1	0.9	0.6	0.7	0.4	0.7	1.9
Comparative body size at age 10	2.4	6.5	13.2	-1.9	-3.1	-1.8	-1.9	-2.6	-2.9	3.0	-3.6	-2.7	-2.6	0.0
Number of full brothers	0.7	0.9	2.9	-0.4	1.0	0.6	1.7	-0.5	0.8	-1.4	-0.1	-0.8	-0.7	-1.1
Worry too long after embarrassment	0.4	0.7	1.9	1.2	0.9	1.1	-0.3	0.8	-0.3	0.1	1.4	0.5	0.9	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.4	0.3	-0.4	0.8	-0.3	0.3	-0.4	-0.1	-0.3	-0.2	-0.7
Wheeze or whistling in the chest in last year	0.2	0.3	1.9	0.2	-1.4	0.5	0.2	-0.7	0.1	-0.1	-0.2	-0.7	-0.3	-0.3
Number of children fathered	0.2	0.2	1.0	-0.0	0.6	0.1	0.1	-0.0	-0.7	-0.0	0.1	-0.0	-0.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	6.0	0.8	2.5	1.2	0.6	1.4	-0.2	-1.4	1.9	1.3	1.5	-0.5
Age at first live birth	1.3	2.3	6.1	0.4	2.5	1.4	0.9	2.1	1.5	-1.3	1.4	1.7	1.7	-0.2
Pulse wave peak to peak time	0.2	0.3	0.9	-0.2	0.4	-0.7	0.2	0.3	-0.2	0.6	-0.6	0.5	0.1	1.0
Health satisfaction	1.0	1.4	4.2	-1.0	-0.4	0.4	1.1	-1.8	-0.4	-0.2	-0.9	-2.1	-1.7	-1.2
Shortness of breath walking on level ground	0.4	0.5	2.1	-0.9	1.1	0.2	1.4	-0.3	0.3	-0.9	-0.3	-0.4	-0.1	-0.3
Qualifications: College or University degree	0.4	1.2	6.2	0.3	2.5	-1.4	1.3	0.7	0.1	-0.6	0.1	0.1	-0.2	-1.3
Eye problems/disorders: None of the above	0.8	1.0	4.8	-0.1	-1.2	1.4	-2.2	0.5	-0.3	0.6	0.0	1.0	1.0	0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	0.5	0.6	-0.1	-0.0	-0.0	0.2	0.1	0.4	-0.2	-0.1	0.1
Emphysema/chronic bronchitis	0.9	1.0	2.3	0.9	-0.0	-1.5	-1.0	1.4	1.0	-0.1	0.9	1.3	1.4	0.1
Medication for pain relief, constipation, heartburn	2.0	3.4	9.8	1.8	2.2	-0.9	-0.3	3.1	2.0	-0.4	1.2	2.7	2.3	0.4
Neck or shoulder pain in last month	0.6	0.8	4.8	0.7	0.2	2.2	0.6	0.1	1.0	-0.9	1.2	0.3	0.6	0.1
Medication: Blood pressure	0.6	1.1	3.4	1.2	-1.2	0.8	-1.5	-0.4	0.6	1.0	0.8	0.1	0.4	1.8
Angina (self-reported)	0.5	0.6	2.2	-0.2	-0.4	-0.2	0.6	-1.5	-0.5	-0.2	0.1	-1.3	-0.9	-1.1
Migraine (self-reported)	1.8	2.2	8.5	0.3	-2.9	-1.0	-2.2	-1.0	-1.2	2.2	-1.2	-0.3	-0.7	0.6
Medication: Ibuprofen	1.5	1.8	5.1	-0.4	-0.8	0.8	1.4	-1.9	-0.3	-1.0	-0.3	-2.2	-2.0	-1.5
Medication: Allopurinol	0.3	0.4	1.1	-0.6	-0.3	0.3	1.1	-0.9	-0.0	-0.1	-0.3	-0.9	-0.7	0.6
Medication: Omeprazole	2.8	3.3	8.1	-2.2	-0.9	0.7	0.7	-2.8	-2.4	0.7	-2.0	-2.5	-2.2	-0.7
Medication: Seretide 50 evohaler	0.7	0.8	2.0	1.3	-0.2	0.0	0.0	1.0	0.9	-0.8	1.4	1.0	1.1	-0.4
Mean time to correctly identify matches	1.0	1.9	4.3	1.0	-0.3	1.2	-2.0	1.4	1.1	0.6	0.4	1.6	2.0	2.1
Heart disease (mother)	0.2	0.3	0.7	-0.6	0.1	0.2	-0.0	-0.6	-0.7	0.2	0.4	-0.8	-0.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.9	-0.3	0.5	-1.2	-1.5	1.2	-0.2	0.9	0.5	1.1	1.0	2.2
Whole body fat mass	0.3	1.2	3.1	0.0	-0.1	1.3	1.6	-1.1	0.0	-1.3	-0.6	-1.3	-1.1	-1.8
Leg fat mass (right)	0.4	1.7	4.1	-0.2	-0.2	0.9	1.6	-1.6	-0.3	-1.3	-1.0	-1.7	-1.6	-2.0
Arm predicted mass (right)	1.5	7.5	16.0	-2.1	-1.2	-1.6	1.3	-3.6	-3.5	0.6	-3.0	-3.8	-4.0	-2.8
Pulse rate, automated reading	0.4	1.3	5.6	-0.5	1.8	0.1	1.6	0.1	-0.6	-1.3	-0.5	0.2	0.2	-2.4
Alcohol intake frequency.	1.2	2.8	6.5	-0.8	-2.4	-0.0	-1.7	-1.7	-2.1	2.6	-1.1	-1.4	-1.4	1.4
Comparative height size at age 10	0.1	0.6	2.1	-0.9	-1.3	1.4	0.1	-0.2	-0.5	-0.7	-0.5	0.1	0.2	-0.8
Number of full sisters	0.1	0.1	0.4	0.6	-0.6	0.0	0.2	-0.2	-0.1	-0.2	0.7	-0.2	0.0	0.2
Suffer from ‘nerves’	0.6	0.9	3.0	1.0	-1.7	-0.1	-1.4	-0.5	0.1	1.1	0.5	-0.1	0.0	1.6
Overall health rating	1.6	3.3	9.8	-1.8	-1.9	0.4	0.6	-3.1	-1.3	-0.3	-1.5	-2.7	-2.0	-2.0
Chest pain or discomfort	1.8	2.6	8.0	-0.2	-0.8	1.8	1.6	-2.1	0.3	-1.3	-0.1	-2.2	-1.8	-2.8
Had major operations	0.8	0.9	3.8	-0.3	1.6	-0.7	1.9	-0.6	0.0	-1.0	0.3	-1.0	-0.5	-0.6
Age at last live birth	0.8	1.2	3.7	0.7	1.9	0.8	0.8	1.2	1.2	-0.6	1.4	1.0	1.0	0.4
Family relationship satisfaction	0.5	0.6	1.7	1.3	0.2	-0.2	0.4	0.5	0.8	-1.1	1.3	0.3	0.4	-0.9
Leg pain on walking	1.1	1.4	3.8	-1.9	1.0	-0.4	1.5	-1.0	-1.4	0.2	-1.2	-1.2	-1.4	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	4.6	1.1	-1.2	-1.2	-1.5	0.3	0.4	1.8	0.5	0.9	0.6	2.1
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.0	-0.6	-1.0	0.7	-0.0	-0.4	0.2	-0.8	-0.3	-0.0	0.3	0.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	5.1	0.8	0.5	-1.5	-0.2	1.3	0.9	0.6	1.1	1.1	0.7	2.3
Medication: Aspirin	1.4	1.9	4.5	-1.1	-1.0	-0.1	-0.5	-1.9	-2.1	1.1	-1.4	-1.9	-1.7	-0.2
Supplements: Vitamin C	0.2	0.3	1.2	-0.3	0.1	-0.8	0.1	-0.2	-0.9	0.0	-0.4	0.2	0.1	-1.1
Knee pain experienced in last month	0.1	0.2	1.0	0.3	-0.0	0.5	-0.2	0.7	0.4	0.4	0.1	0.5	0.3	1.0
Hypertension (Self-reported)	0.6	1.7	4.5	1.8	-1.0	0.9	-1.8	0.5	2.1	-0.4	1.6	0.7	1.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.5	-1.6	0.7	1.9	1.1	-0.7	-0.1	-0.9	-1.0	-0.4	-0.5	-1.8
Illnesses of father: Heart disease	1.5	2.0	3.5	-1.9	0.3	0.6	1.5	-1.6	-1.4	0.1	-1.9	-1.7	-1.8	-1.4
Illnesses of siblings: Diabetes	0.4	0.5	2.4	0.4	0.9	1.6	0.3	-0.2	-1.0	0.2	-0.0	-0.6	-0.5	-0.7
Smoking status: Previous	0.6	0.9	3.5	1.9	0.3	0.7	-0.6	0.2	0.9	0.2	1.8	-0.1	0.4	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.2	-0.8	-1.2	-0.8	-0.2	-1.8	-2.0	0.8	-1.8	-1.4	-1.6	-1.3
Whole body fat-free mass	1.0	5.9	12.8	-1.5	-0.9	-0.9	1.4	-3.2	-3.2	0.3	-2.3	-3.4	-3.6	-3.0
Leg fat-free mass (right)	0.8	4.3	8.8	-1.0	-0.6	-0.5	1.4	-2.6	-2.8	-0.1	-1.9	-2.8	-3.0	-3.0
Arm fat percentage (left)	0.3	1.0	3.2	1.0	0.8	1.2	1.2	0.0	0.7	-1.6	0.4	-0.2	-0.1	-1.8
Average weekly red wine intake	1.4	2.0	6.2	0.5	2.5	-1.4	0.2	2.0	1.7	-1.0	0.6	1.7	1.7	-0.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.8	-1.3	0.7	0.0	0.7	-0.9	-1.7	1.2	-1.1	-1.3	-1.6	0.5
Mood swings	0.3	0.5	1.8	0.9	-0.1	0.8	0.5	-0.4	-0.5	-0.7	0.9	-0.3	-0.2	-1.3
Loneliness, isolation	1.6	2.2	5.8	-1.0	0.1	0.5	1.8	-2.1	-0.7	-1.7	-0.1	-2.0	-1.4	-2.4
Long-standing illness, disability or infirmity	1.6	2.4	6.9	-1.1	-2.6	0.5	-1.2	-2.3	-1.1	1.6	-1.0	-1.9	-1.6	0.4
Ever had bowel cancer screening	0.6	0.7	3.5	0.3	-1.9	1.0	-1.4	-0.3	0.4	0.6	-0.2	-0.1	0.3	0.6
Diabetes diagnosed by doctor	2.0	3.2	4.6	-1.3	-1.9	1.9	-1.1	-2.0	-1.9	2.1	-1.5	-1.8	-1.8	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.9	1.6	-1.1	-0.7	-1.6	1.0	1.0	0.8	2.0	1.6	1.2	2.0
Friendships satisfaction	0.5	0.6	1.3	0.7	1.0	0.5	0.7	0.2	0.5	-1.1	1.1	0.1	0.4	-1.1
Qualifications: nursing, teaching	1.9	3.0	7.8	1.4	2.8	-0.4	1.3	2.4	1.9	-2.0	1.3	1.7	1.3	-1.1
Commuting to job workplace: Walk	1.1	1.2	3.2	1.6	-0.6	1.8	-1.0	0.7	1.0	0.6	1.3	0.9	0.8	0.9
Eye problems/disorders: Cataract	0.3	0.3	0.8	0.6	0.9	-0.1	0.8	0.5	0.4	-0.5	0.7	0.4	0.4	0.4
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	10.5	1.1	-1.5	-2.4	-3.2	0.6	0.7	2.4	-0.1	0.9	0.7	2.3
Medication for cholesterol	0.3	0.4	1.1	0.1	0.7	1.0	0.7	-0.2	-1.0	0.8	-0.4	-0.4	-0.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.6	-0.7	-1.9	-0.2	0.1	-1.8	-0.3	-0.4	-0.1	-1.7	-1.0	-0.2
Back pain experienced in last month	0.6	0.8	3.7	-0.4	-0.7	1.9	-1.0	0.0	0.2	-0.0	1.0	0.5	0.7	1.4
Mineral and other dietary supplements	0.6	0.8	2.5	-0.1	-1.4	-0.7	-1.6	-0.1	-0.9	1.2	0.1	-0.1	-0.2	1.1
Breast cancer (self-reported)	0.3	0.3	1.0	0.4	0.4	0.5	0.5	0.4	1.0	-0.9	0.5	0.2	0.3	-0.6
Asthma (self-reported)	0.5	0.9	4.4	0.2	-0.2	1.4	0.7	0.1	0.8	-1.6	0.2	-0.1	0.0	-2.1
Osteoporosis (self-reported)	1.2	1.5	4.8	-1.0	-0.4	-0.3	0.3	-1.8	-2.2	1.0	-1.0	-1.3	-1.7	-0.5
Osteoarthritis (self-reported)	0.1	0.2	0.9	-0.3	-1.0	-0.3	-0.6	-0.2	-0.2	0.2	-0.3	-0.1	-0.2	-0.1
Medication: Aspirin	1.4	1.9	4.6	-1.0	-1.3	0.0	-0.6	-2.1	-1.9	0.9	-1.2	-1.9	-1.7	-0.5
Medication: Gliclazide	0.7	0.7	2.1	-1.2	-0.4	0.9	-0.4	-0.5	-1.5	0.5	-1.4	-0.5	-0.9	0.3
Illnesses of father: None of the above (group 1)	1.0	1.3	3.8	1.1	-0.6	-1.9	-1.1	1.1	0.6	0.2	1.2	1.5	1.4	0.6
Smoking status: Current	0.2	0.4	0.9	-0.8	0.0	0.0	0.4	-0.9	-0.8	0.4	-0.5	-0.8	-0.7	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	5.0	-2.0	1.4	-1.6	2.1	-1.5	-1.3	-0.7	-2.1	-2.0	-2.0	-2.2
Whole body water mass	1.0	5.6	12.2	-1.4	-0.8	-0.8	1.4	-3.1	-3.1	0.2	-2.2	-3.3	-3.5	-3.0
Leg predicted mass (right)	0.8	4.4	9.0	-1.1	-0.6	-0.4	1.4	-2.6	-2.8	-0.1	-1.9	-2.8	-3.0	-3.0
Arm fat mass (left)	0.3	1.4	5.1	0.6	0.3	1.0	1.6	-1.0	0.0	-1.5	-0.1	-1.2	-1.1	-2.2
Number of self-reported non-cancer illnesses	0.6	1.0	5.8	0.3	-2.4	0.4	-1.6	-0.7	1.0	-0.3	0.7	-0.3	0.2	-0.1
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.6	-0.3	-0.4	-0.3	0.5	1.0	-0.2	0.5	0.4	0.4	0.5
Miserableness	0.4	0.7	2.5	1.6	0.5	1.1	0.3	0.2	0.0	-1.0	1.4	0.0	0.4	-0.9
Guilty feelings	0.4	0.5	1.8	1.0	-0.4	0.5	-0.5	0.4	0.3	-0.3	1.3	0.9	1.0	0.5
Wears glasses or contact lenses	0.4	0.5	1.5	0.0	1.2	-0.6	0.9	0.5	0.5	-1.2	0.3	0.1	0.2	-0.6
Ever taken oral contraceptive pill	0.4	0.4	1.4	0.5	0.3	-0.3	0.4	0.3	0.8	-1.0	0.8	0.3	0.2	-1.2
Hearing aid user	0.4	0.5	1.6	0.3	-0.3	1.0	-1.2	0.1	-0.4	1.3	-0.3	-0.1	-0.2	0.9
Mother’s age at death	0.8	1.1	2.7	-0.8	0.3	-1.6	0.8	-1.1	-1.0	0.4	-1.4	-0.9	-1.1	-1.1
Financial situation satisfaction	2.1	2.6	6.1	-1.9	-1.0	0.2	0.6	-2.3	-2.0	0.2	-1.4	-2.5	-2.1	-1.4
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.8	-0.8	1.2	1.9	1.4	0.2	-0.4	-1.7	1.0	-0.0	0.1	-0.4
Commuting to job workplace: Public transport	0.3	0.4	1.7	0.8	-0.3	-1.3	-0.2	0.4	0.3	0.9	0.0	0.3	-0.0	0.8
Eye problems/disorders: Glaucoma	1.2	1.4	5.6	0.6	2.4	-1.5	1.6	1.0	1.0	-1.1	1.0	0.4	0.4	-0.3
Medication: Blood pressure	0.2	0.5	2.1	0.2	-1.3	-0.4	-1.4	-0.4	0.9	-0.3	0.2	-0.2	0.1	0.3
Pain type(s) experienced in last month: Hip pain	0.9	1.1	4.6	-0.4	-2.1	-1.1	-0.7	-1.2	-1.5	1.2	-0.4	-0.5	-0.7	0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	3.1	1.0	0.4	1.8	0.0	0.5	0.7	-0.3	-0.0	0.5	0.5	-0.4
High cholesterol (Self-reported)	0.3	0.6	2.4	-0.2	-1.4	-0.0	-1.6	-0.4	-0.3	0.4	-0.8	0.1	-0.1	-1.1
Medication: Bendroflumethiazide	0.4	0.6	1.8	1.2	-0.3	-0.4	-0.8	0.4	1.3	-0.3	1.3	0.4	0.4	0.0
Medication: Paracetamol	0.4	0.6	2.0	0.0	-0.5	0.6	0.6	-1.0	-0.8	-0.5	0.1	-1.1	-1.0	-1.4
Medication: Lisinopril	0.6	0.7	2.0	-1.4	0.1	1.3	1.0	-0.7	-0.3	-1.0	-0.9	-0.6	-0.5	-0.7
Medication: Atorvastatin	0.7	0.8	2.8	-1.2	-1.7	0.0	-0.9	-1.4	-0.3	0.4	-0.8	-0.7	-0.4	0.6
Illnesses of father: High blood pressure	0.2	0.2	0.9	0.8	-0.4	0.0	-0.6	-0.1	-0.2	0.1	-0.2	-0.2	-0.2	-0.9
Alcohol drinker status: Never	3.1	3.7	10.6	-1.1	-1.0	-0.2	0.7	-2.7	-1.9	1.9	-1.5	-3.2	-3.3	-0.4
Ever smoked	0.3	0.6	1.6	1.1	-0.5	0.8	-0.9	0.1	-0.0	0.7	1.1	0.0	0.3	1.3
Basal metabolic rate	0.9	4.8	10.2	-1.2	-0.7	-0.4	1.6	-2.9	-2.6	-0.3	-1.9	-3.1	-3.2	-3.1
Leg fat percentage (left)	0.2	0.6	1.6	-0.1	-0.4	1.3	0.8	-0.9	0.4	-0.9	-0.8	-1.0	-0.7	-0.9
Arm fat-free mass (left)	1.2	6.0	13.0	-1.7	-0.6	-0.7	1.8	-3.3	-2.8	-0.1	-2.4	-3.5	-3.6	-3.0
Number of operations (self-reported)	0.4	0.7	1.7	-0.4	-0.7	-0.4	-0.8	-1.3	-0.3	1.2	-0.5	-1.1	-0.8	0.6
Average weekly beer plus cider intake	0.8	1.2	6.1	0.3	-2.5	0.8	-1.1	-1.1	-0.4	1.0	-0.4	-0.7	-0.6	1.4
Irritability	0.3	0.6	1.2	-1.0	0.8	0.2	0.9	-0.5	-1.1	-0.3	-0.7	-0.6	-0.6	-1.0
Risk taking	0.2	0.3	1.3	-0.6	1.1	0.0	0.4	0.4	-0.6	-0.6	-0.3	0.3	0.4	-0.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.3	-1.3	-0.1	1.4	1.0	-1.3	-0.9	-0.2	-1.8	-1.7	-1.5	-0.7
Fractured/broken bones in last 5 years	0.3	0.4	3.0	-0.3	-0.5	1.7	0.1	-0.0	0.6	-0.1	-0.3	0.2	-0.0	-0.8
Age started oral contraceptive pill	0.6	0.8	3.2	0.2	-0.5	1.2	-1.1	0.8	0.4	0.7	0.4	0.7	0.3	1.8
Diastolic blood pressure, automated reading	0.6	1.9	4.1	-0.0	-2.0	-1.9	-0.6	-1.8	-0.9	1.3	-1.3	-1.7	-1.8	0.1
Ever depressed for a whole week	0.6	0.8	1.8	1.3	-0.3	0.3	-1.2	0.6	0.9	0.5	0.8	0.4	1.0	1.3
Unable to work because of sickness or disability	0.1	0.2	0.4	0.5	-0.2	0.6	-0.5	-0.5	0.1	0.6	-0.1	-0.2	-0.0	0.0
Commuting to job workplace: Cycle	1.5	1.8	14.1	0.4	-0.3	-3.8	-1.3	0.1	-0.7	1.7	-0.4	0.3	-0.3	0.4
Myopia	0.6	0.8	2.9	0.7	-1.6	0.8	-1.7	0.1	0.4	0.8	0.3	0.3	0.3	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.7	-1.0	1.2	-1.4	1.0	0.3	-1.7	0.7	-1.3	0.0	-0.6	-0.5
Cholesterol lowering medication	0.2	0.3	1.4	-0.3	-0.4	-0.8	-0.2	-0.4	0.3	-0.6	0.0	-0.4	-0.5	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	5.7	-1.8	-0.5	0.4	0.4	-2.2	-2.4	0.9	-1.7	-1.9	-1.6	-0.3
Pain experienced in last month	0.4	0.6	1.6	1.0	0.7	-1.3	-0.6	1.3	0.8	0.2	0.4	0.9	0.5	0.3
Supplements: Calcium	1.2	1.3	4.0	-0.7	-0.8	-1.2	1.0	-2.0	-0.5	-0.1	-0.6	-1.7	-1.7	-0.7
Basal cell carcinoma (self-reported)	0.8	0.9	2.1	-0.2	1.2	0.5	0.6	1.3	1.1	-1.4	0.6	1.1	1.2	0.5
Heart attack/myocardial infarction (self-reported)	1.6	2.1	6.4	-1.2	-2.3	0.9	0.0	-2.5	-1.0	0.4	-0.7	-2.2	-1.6	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	0.5	-0.6	0.5	-0.4	0.3	0.2	-0.4	0.5	0.2	0.2	-0.4
Heart disease (siblings)	0.6	0.8	5.5	0.2	0.2	2.3	0.0	0.6	0.2	-0.0	1.0	0.5	0.9	0.6
Alcohol drinker status: Previous	0.4	0.5	1.5	-0.8	-0.5	0.5	-0.3	-0.9	-0.3	0.1	-1.2	-0.8	-0.7	-0.5
Pack years of smoking	0.2	0.3	1.4	0.2	-0.6	0.3	-1.2	0.2	-0.3	0.4	-0.3	0.4	0.6	-0.1
Impedance of whole body	0.7	3.8	10.2	0.6	0.8	2.9	0.9	1.7	3.2	-2.0	1.7	2.1	2.5	0.9
Leg fat mass (left)	0.4	1.5	3.7	-0.2	-0.3	1.0	1.4	-1.4	-0.2	-1.2	-0.9	-1.6	-1.5	-1.9
Arm predicted mass (left)	1.1	5.5	12.4	-1.6	-0.9	-1.0	1.4	-3.2	-2.9	0.2	-2.2	-3.4	-3.5	-2.6