TWAS hub - ASCL2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0687	0.0214	9.8e-05	0.048	0.022	0.033	0.028	0.032	8.8e-08	2.5e-04	9.9e-06	4.1e-05	1.1e-05
2	YFS	Blood	0.2780	0.0282	0.0e+00	0.074	0.227	0.264	0.267	0.253	3.3e-23	1.2e-72	4.6e-86	2.1e-87	3.3e-82
3	TCGA	Breast Invasive Carcinoma	0.0224	0.0114	2.7e-03	0.015	0.011	0.012	NA	0.016	3.3e-04	1.6e-03	1.1e-03	NA	2.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Prostate Cancer	12.3	17.2	46.5	1.6	1.6	6.8
Birth weight	4.2	9.1	19.9	0.7	2.6	4.5
Migraine (self-reported)	3.7	4.6	7.5	0.3	-2.5	2.7
Hayfever/allergic rhinitis (self-reported)	3.1	4.1	6.2	-2.5	-0.6	2.4
Leg pain on walking	3.1	3.9	7.6	1.9	2.8	0.9
Handedness (chirality/laterality): Left-handed	3.1	3.7	6.4	2.0	2.5	-0.8
Number of self-reported non-cancer illnesses	2.9	5.0	7.5	-2.7	-2.7	0.3
Average weekly fortified wine intake	2.7	3.1	7.0	2.6	1.4	0.6
Hearing aid user	2.6	2.9	7.6	1.0	0.5	-2.8
Chronic bronchitis/emphysema (father)	2.5	2.9	8.6	0.4	0.2	-2.9
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	3.8	-2.0	-1.9	-1.3
Verbal and Numeric Reasoning (VNR)	2.4	5.7	9.2	1.2	3.0	2.5
Medication: Ramipril	2.4	3.1	5.9	-1.3	-2.4	-1.3
Supplements: Zinc	2.3	2.5	7.1	0.5	0.4	2.7
Qualifications: CSEs or equivalent	2.3	3.0	3.2	1.7	1.8	1.6
Family relationship satisfaction	2.2	2.7	4.0	-2.0	-1.8	1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	5.5	-1.1	-2.3	-0.5
Stomach or abdominal pain in last month	2.1	2.6	6.8	-0.9	0.2	2.6
Depression (Nagel 2018)	2.0	2.9	4.0	-2.0	-1.9	-1.2
Hand grip strength (left)	2.0	5.3	15.0	0.9	0.4	3.9
Number of treatments/medications taken	2.0	3.6	6.0	-2.4	-2.2	-0.0
Medication: Gliclazide	2.0	2.3	3.5	1.9	0.6	1.7
Intelligence (Savage-Jansen 2018)	1.9	5.8	8.0	1.6	2.6	2.8
Chest pain or discomfort	1.9	2.8	4.7	-1.8	-0.6	2.2
Body Mass Index (BMI) (2010)	1.8	2.4	6.1	-0.2	1.1	2.5
High blood pressure	1.8	5.0	7.2	-2.5	-2.7	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.7	8.7	1.4	3.0	2.5
Ever highly irritable/argumentative for 2 days	1.8	2.2	4.3	-2.1	-0.3	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	7.7	1.9	0.1	2.8
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	3.5	1.9	1.7	0.2
Medication: Metformin	1.7	2.5	4.0	2.0	-0.2	-1.8
Impedance of arm (left)	1.7	7.8	17.0	-2.3	-0.9	-4.1
Medication: Bendroflumethiazide	1.7	2.5	4.8	-1.5	-2.2	-0.6
Impedance of whole body	1.7	8.9	21.4	-2.2	-0.5	-4.6
Lupus	1.6	2.5	3.9	-1.8	-2.0	0.3
Type 2 Diabetes (T2D) (2018)	1.6	3.0	9.0	3.0	-0.3	-0.3
Hand grip strength (right)	1.6	4.3	12.7	0.2	-0.4	3.6
Impedance of arm (right)	1.6	7.5	15.4	-2.6	-0.7	-3.9
Exposure to tobacco smoke at home	1.6	1.8	2.9	-0.6	-1.7	1.5
Pulse wave reflection index	1.6	2.0	2.7	-1.1	-1.6	1.4
Supplements: Vitamin C	1.6	1.9	4.5	1.1	0.2	2.1
Hypertension (Self-reported)	1.6	4.6	7.1	-2.2	-2.7	-1.4
Illnesses of father: Heart disease	1.6	2.2	4.1	1.6	2.0	-0.3
Risk taking	1.6	2.4	2.9	1.7	1.7	1.2
Vascular/heart problems diagnosed by doctor	1.6	4.4	5.7	2.4	2.3	1.6
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.0	2.0	1.1	0.0
Impedance of leg (left)	1.5	7.1	18.1	-1.8	-0.3	-4.3
Diabetes (self-reported)	1.5	2.3	6.2	2.5	0.6	-0.4
Alcohol intake versus 10 years previously	1.5	2.3	5.0	2.2	0.9	1.0
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	8.0	1.1	2.8	2.4
Chronic bronchitis/emphysema (mother)	1.5	1.8	3.5	-1.9	-1.0	0.9
Exposure to tobacco smoke outside home	1.5	2.0	3.2	-1.6	-1.8	-0.4
Heart disease (mother)	1.5	1.8	3.1	0.9	1.3	-1.8
HbA1C	1.4	1.6	3.0	1.7	0.2	-1.3
Impedance of leg (right)	1.4	6.6	15.8	-1.9	-0.6	-4.0
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.7	1.2	0.8	-1.6
Qualifications: None of the above	1.4	3.0	5.0	-1.7	-2.2	-1.1
Hair/balding pattern: Pattern 4	1.4	3.4	4.0	-1.5	-2.0	-2.0
Worry too long after embarrassment	1.4	2.3	4.2	1.2	1.2	-2.0
Medication: Blood pressure	1.4	2.4	3.9	-0.7	-1.7	-2.0
Osteoporosis (self-reported)	1.4	1.8	3.2	1.8	1.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.5	1.1	2.1	1.8
Ever taken oral contraceptive pill	1.4	1.5	3.0	-1.7	-0.7	-1.0
Average weekly beer plus cider intake	1.4	2.0	4.8	-1.0	-2.2	0.5
Medication: Atenolol	1.3	1.6	3.3	-1.8	-1.2	-0.4
Allergy	1.3	3.0	6.1	2.5	0.8	-1.5
Happiness	1.3	1.5	3.7	-1.9	-0.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.6	1.0	1.9	-0.2
Mouth/teeth dental problems: Dentures	1.3	2.2	5.9	-0.2	0.8	2.4
Forced vital capacity (FVC), Best measure	1.3	4.9	8.3	0.8	2.9	2.4
Medication: Ibuprofen	1.3	1.5	3.5	-1.0	-0.2	1.9
Myopia	1.3	1.8	3.2	-0.8	-1.8	1.3
Ovarian Cancer	1.2	1.6	4.6	2.2	-0.1	-0.3
Respiratory disease	1.2	2.7	5.8	-2.4	-0.4	1.5
Diabetes (mother)	1.2	1.5	3.9	2.0	-0.8	0.2
Maternal smoking around birth	1.2	1.8	3.1	1.7	0.1	1.5
Fluid intelligence score	1.2	2.4	4.2	1.3	2.1	1.2
Peak expiratory flow (PEF)	1.2	2.7	5.5	0.7	2.3	1.4
Headache pain in last month	1.2	2.1	4.6	-2.1	-1.3	0.3
Arm fat-free mass (right)	1.2	6.0	14.8	1.3	1.3	3.9
Angina (self-reported)	1.2	1.6	3.8	-0.3	1.0	-2.0
Arm predicted mass (right)	1.2	6.3	15.4	1.4	1.3	3.9
Commuting to job workplace: Walk	1.2	1.3	2.4	-1.2	-1.5	-0.3
Arm fat-free mass (left)	1.2	6.1	16.2	0.8	1.2	4.0
Worry (Nagel 2018)	1.1	2.2	3.3	-1.5	-1.8	-1.1
Blood Red Count	1.1	11.1	29.7	-1.8	-5.5	0.5
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.0	-1.2	-1.7	-0.3
Leg fat-free mass (left)	1.1	5.8	16.4	0.6	0.8	4.0
Hayfever, allergic rhinitis or eczema	1.1	2.3	5.8	-2.4	-0.5	0.9
Leg predicted mass (left)	1.1	5.7	16.0	0.6	0.8	4.0
Alcohol usually taken with meals	1.1	1.8	2.8	1.7	1.4	0.9
Time employed in main current job	1.1	1.3	3.3	-0.2	-0.7	-1.8
Birth weight of first child	1.1	2.0	4.1	2.0	1.1	0.9
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.3	0.4	1.4	1.8
Comparative body size at age 10	1.1	3.0	5.2	1.9	-0.1	2.3
Medication: Omeprazole	1.1	1.3	2.6	1.1	1.6	0.2
Had major operations	1.1	1.2	3.5	-0.0	1.9	-0.5
Whole body fat-free mass	1.1	6.2	16.3	1.1	1.0	4.0
Ever had bowel cancer screening	1.1	1.3	1.7	-1.2	-1.3	-0.9
Leg predicted mass (right)	1.1	5.6	15.4	0.8	0.9	3.9
Commuting to job workplace: Cycle	1.1	1.3	2.7	1.2	-0.1	1.6
Fasting Glucose	1.0	1.2	2.3	-0.5	-1.0	-1.5
BMI	1.0	5.8	16.3	1.0	0.2	4.0
Angina	1.0	1.3	2.5	0.1	1.2	-1.6
Taking other prescription medications	1.0	1.6	2.2	-1.4	-1.5	-0.7
Heart attack	1.0	1.3	2.5	-1.1	-0.2	-1.6
Trunk fat-free mass	1.0	5.6	14.8	1.1	0.9	3.9
Trunk predicted mass	1.0	5.5	14.4	1.1	1.0	3.8
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.4	-0.7	-0.1	2.3
Wheeze or whistling in the chest in last year	1.0	1.8	3.2	-1.8	-1.2	0.9
Suffer from ‘nerves’	1.0	1.6	2.5	-1.0	-1.6	-1.1
Leg fat-free mass (right)	1.0	5.6	15.2	0.9	0.9	3.9
Diabetes diagnosed by doctor	1.0	1.6	2.5	1.6	-0.1	-1.6
Friendships satisfaction	1.0	1.2	2.0	-1.2	-0.5	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.5	-1.6	-1.0	0.1
Asthma (self-reported)	1.0	2.0	3.3	-1.6	-0.3	1.8
Illnesses of father: None of the above (group 1)	1.0	1.2	2.9	-0.8	-1.7	0.2
Whole body water mass	1.0	6.0	15.8	1.0	1.0	4.0
Medication: Atorvastatin	1.0	1.2	1.8	-0.8	-1.0	-1.4
Basal metabolic rate	1.0	5.5	15.7	0.6	0.8	4.0
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.6	-1.2	-0.2	-1.6
Arm predicted mass (left)	1.0	5.2	13.7	1.0	1.0	3.7
Blood Eosinophil Count	0.9	6.7	17.4	-1.2	-4.2	1.1
Allergy or Eczema	0.9	2.3	6.1	-2.5	0.1	1.0
Hypothyroidism (self reported)	0.9	2.0	5.7	-0.1	0.6	2.4
Townsend deprivation index at recruitment	0.9	1.3	3.2	-0.1	-1.8	0.7
Serious illness, injury or assault to yourself	0.9	1.1	2.4	-0.6	-0.6	1.5
Forced vital capacity (FVC)	0.9	3.3	6.4	0.8	2.5	1.8
Asthma	0.9	1.7	3.1	-1.4	-0.1	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.2	-0.6	0.1	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.7	1.3	0.7	-1.0
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.2	-0.2	-0.2	-1.8
Medication: Aspirin	0.9	1.2	2.9	1.7	0.6	-0.7
Medication: Blood pressure	0.9	1.7	3.8	-1.2	-1.9	-0.2
Alcohol drinker status: Never	0.9	1.1	1.5	1.2	1.0	-0.8
Primary Biliary Cirrhosis	0.8	1.1	2.9	-0.0	-1.7	0.7
Sensitivity / hurt feelings	0.8	1.4	2.7	-0.4	-1.2	1.6
Had menopause	0.8	1.0	1.3	1.1	1.2	-0.6
Number of live births	0.8	1.1	1.7	-0.9	-1.3	0.9
Depression (self-reported)	0.8	1.0	1.5	-1.2	-1.2	0.2
Neck or shoulder pain in last month	0.8	1.1	1.4	-1.1	-0.7	-1.2
Mean time to correctly identify matches	0.8	1.5	2.4	-0.6	-1.3	-1.5
Age at last live birth	0.8	1.2	3.1	0.1	0.6	-1.8
Eye problems/disorders: Cataract	0.8	0.9	2.6	-0.3	0.4	-1.6
Ever had prostate specific antigen (PSA) test	0.8	1.0	2.5	-0.3	0.5	1.6
Diastolic blood pressure, automated reading	0.8	2.5	3.9	-0.3	-2.0	1.9
Ever depressed for a whole week	0.8	1.0	1.3	-1.1	-1.0	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.6	-1.2	-1.3	0.4
Current tobacco smoking	0.7	1.2	2.3	0.9	1.5	-0.6
Body mass index (BMI)	0.7	3.1	8.9	-0.5	-0.2	3.0
Nervous feelings	0.7	1.3	2.6	-1.0	-1.6	-0.6
Weight	0.7	3.4	9.6	-0.7	0.3	3.1
Arm fat mass (right)	0.7	3.0	7.0	-1.4	0.0	2.6
Tense / ‘highly strung’	0.7	1.1	1.4	-1.2	-1.1	-0.8
Shortness of breath walking on level ground	0.7	0.9	1.4	-0.2	1.1	1.2
Osteoarthritis (self-reported)	0.7	0.9	1.6	-0.1	-1.0	1.3
Arm fat mass (left)	0.7	2.7	6.4	-1.4	-0.1	2.5
Average weekly champagne plus white wine intake	0.7	1.0	1.2	-1.1	-1.1	-0.7
Heart disease (siblings)	0.7	0.8	2.1	-0.0	0.6	-1.5
Schizophrenia (2018)	0.6	1.1	3.3	-0.3	-0.2	-1.8
Alzheimer’s Disease (including proxy)	0.6	0.8	2.0	-0.4	0.4	-1.4
Crohns Disease (2017)	0.6	1.4	2.7	-1.2	-1.7	0.1
Major Depression (MDD)	0.6	0.7	2.2	0.0	0.0	1.5
Coronary Artery Disease (CAD)	0.6	0.7	1.4	0.0	-0.8	1.2
Lung FVC	0.6	3.1	8.1	1.1	2.9	0.2
Relative age of first facial hair	0.6	1.3	1.8	0.9	1.0	-1.4
Age when periods started (menarche)	0.6	1.5	3.1	-1.8	-0.6	-1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.3	1.1	0.7	0.4
Supplements: Glucosamine	0.6	0.8	1.7	0.0	0.9	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	-1.3	-0.9	0.6
Illnesses of siblings	0.6	0.9	1.6	0.2	1.0	1.3
Hair/balding pattern: Pattern 3	0.6	0.9	1.5	1.2	0.9	0.6
Noisy workplace	0.6	0.8	1.3	1.2	-0.7	0.7
Blood clot in the leg (DVT)	0.6	0.8	1.4	-1.0	-1.2	0.0
Qualifications: College or University degree	0.6	2.0	4.1	1.3	2.0	-0.1
Leg fat mass (right)	0.6	2.4	5.8	-1.2	-0.0	2.4
Pulse rate, automated reading	0.6	1.9	3.3	0.9	1.8	1.2
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.0	-1.0	-0.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.1	0.4	-1.4	-0.6
Medication for cholesterol	0.6	1.0	2.1	1.4	0.9	-0.3
Medication: Aspirin	0.6	0.8	1.7	1.3	0.3	-0.8
Guilty feelings	0.6	0.9	1.3	-0.8	-1.1	-0.9
Eye problems/disorders: Glaucoma	0.6	0.8	1.3	0.4	1.1	1.0
Leg fat mass (left)	0.6	2.2	5.2	-1.3	-0.1	2.3
Bipolar Disorder or Schizophrenia	0.5	1.2	2.1	-0.9	-0.9	-1.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	-0.4	-0.1	-1.2
Irritable Bowel Disease (IBD)	0.5	1.1	3.0	-0.6	-1.7	0.3
Blood White Count	0.5	3.8	11.4	0.2	-3.4	0.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	0.8	0.9	0.8	-0.8
Systolic blood pressure, automated reading	0.5	1.5	3.3	-0.0	-1.8	-1.0
Severe depression (siblings)	0.5	0.5	1.2	-0.5	-1.1	-0.4
Medication: Levothyroxine sodium	0.5	0.8	1.1	-0.8	-0.8	1.1
Medication: Simvastatin	0.5	0.7	2.0	0.2	-0.3	1.4
Neuroticism score	0.5	1.0	1.5	-1.2	-1.2	0.1
Hip circumference	0.5	2.0	3.2	-1.6	0.3	1.8
Father’s age at death	0.5	0.6	1.9	-0.2	-0.0	1.4
Pulse rate	0.5	0.9	1.6	1.3	0.9	0.5
Medication: Cholesterol lowering	0.5	0.8	2.1	-0.1	-1.5	-0.4
Prospective memory result	0.5	0.6	1.9	0.0	0.0	1.4
Lung cancer (father)	0.5	0.6	1.7	0.1	-0.4	-1.3
Glaucoma (self-reported)	0.5	0.6	0.9	1.0	0.8	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.2	-1.1	-0.1	0.9
Number of children fathered	0.5	0.6	1.1	0.8	1.1	-0.2
Eye problems/disorders: None of the above	0.5	0.6	1.5	0.3	-1.2	0.6
Emphysema/chronic bronchitis	0.5	0.6	1.3	-0.2	-1.1	0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-1.1	-0.6	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	0.3	1.0	0.8
Back pain experienced in last month	0.5	0.7	1.5	-0.3	-0.7	-1.2
Breast cancer (self-reported)	0.5	0.6	0.8	-0.9	-0.7	-0.7
Bipolar Disorder (2018)	0.4	0.6	1.0	-1.0	-0.9	-0.0
Neuroticism (Nagel 2018)	0.4	0.9	1.3	-0.8	-0.9	-1.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	0.4	1.1	0.3
Ulcerative Colitis (UC)	0.4	0.8	2.3	0.0	-1.5	0.4
Mean Putamen Volume	0.4	0.4	0.7	-0.8	-0.1	0.8
HDL Cholesterol	0.4	0.7	1.9	0.5	1.4	0.2
Smoking Status	0.4	1.0	2.6	0.7	1.6	0.1
Hair Pigment	0.4	10.3	16.1	-1.8	-4.0	-3.4
Diabetes (father)	0.4	0.5	1.4	1.2	0.1	-0.2
Relative age voice broke	0.4	0.5	1.6	0.1	-0.2	-1.2
Multivitamins +/- minerals	0.4	0.5	0.6	0.6	-0.8	-0.7
Waist circumference	0.4	1.5	3.7	-0.9	0.3	1.9
Arm fat percentage (right)	0.4	1.6	2.5	-1.6	-0.0	1.6
Loud music exposure frequency	0.4	0.4	0.7	-0.1	0.7	0.8
Leg fat percentage (right)	0.4	1.4	2.3	-1.5	-0.3	1.3
Number of full brothers	0.4	0.5	0.8	-0.8	0.9	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.6	0.8	0.7	0.6
Whole body fat mass	0.4	1.5	2.7	-1.4	-0.0	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.2	-0.0	-1.1	-0.3
Illnesses of siblings: Diabetes	0.4	0.5	0.7	0.7	0.8	-0.6
Arm fat percentage (left)	0.4	1.5	2.5	-1.4	-0.1	1.6
Qualifications: nursing, teaching	0.4	0.6	1.5	-0.0	1.2	-0.5
Smoking status: Current	0.4	0.6	1.2	0.5	1.1	-0.6
Mother’s age at death	0.4	0.5	0.9	0.2	0.9	0.9
Financial situation satisfaction	0.4	0.5	1.3	0.5	0.3	1.2
High cholesterol (Self-reported)	0.4	0.7	1.5	-0.5	-1.2	0.7
Illnesses of father: High blood pressure	0.4	0.5	1.0	0.1	-0.7	1.0
Irritability	0.4	0.6	1.2	0.7	1.1	-0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.0	-0.7	-1.0	0.1
Breast Cancer	0.3	0.7	1.3	-1.1	-0.6	-0.6
Age at First Birth	0.3	0.4	0.9	0.6	1.0	-0.2
Crohns Disease (2012)	0.3	0.4	0.8	-0.9	-0.7	0.2
Triglycerides	0.3	0.4	1.2	-0.2	-1.1	-0.2
Systolic Blood Pressure	0.3	1.7	4.4	0.3	-2.1	-0.8
Lung FEV1/FVC ratio	0.3	1.7	3.0	1.5	-0.0	1.7
Pack years adult smoking proportion	0.3	0.5	0.8	-0.0	-0.8	0.9
Trunk fat percentage	0.3	1.2	3.6	-1.9	-0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	0.2	-0.8	0.8
Trunk fat mass	0.3	1.3	2.3	-1.5	0.0	1.3
Had other major operations	0.3	0.4	0.5	0.4	-0.7	-0.7
Mouth/teeth dental problems	0.3	0.4	0.8	-0.9	-0.5	-0.4
Pain all over the body in last month	0.3	0.3	0.6	0.7	0.1	0.5
Length of working week for main job	0.3	0.4	0.8	0.5	-0.9	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.3	0.1	-0.3	1.1
Medication: Amlodipine	0.3	0.4	1.1	-0.2	-0.2	-1.1
High blood pressure (siblings)	0.3	0.4	0.8	-0.3	-0.9	-0.6
Body fat percentage	0.3	1.1	2.8	-1.7	-0.1	0.7
Age at first live birth	0.3	0.6	1.8	-0.1	0.2	-1.3
Alcohol intake frequency.	0.3	0.8	2.3	1.5	-0.3	-0.0
Smoking status: Previous	0.3	0.4	1.1	-0.2	-0.1	-1.1
Mineral and other dietary supplements	0.3	0.5	0.7	0.5	-0.8	-0.7
Miserableness	0.3	0.5	1.0	-1.0	-0.6	0.3
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.0	-0.8	0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.1	-0.4	-1.0
Leg fat percentage (left)	0.3	1.1	2.1	-1.4	-0.3	1.1
Number of operations (self-reported)	0.3	0.4	0.7	0.8	0.2	-0.6
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.6	0.3
Alzheimer’s Disease (in father)	0.2	0.3	0.4	-0.5	0.2	-0.7
Reaction Time	0.2	0.3	0.8	-0.2	-0.9	-0.4
Neuroticism (2016)	0.2	0.3	0.8	-0.3	-0.9	-0.1
Rheumatoid Arthritis	0.2	0.2	0.6	-0.4	-0.7	-0.2
Blood Platelet Count	0.2	1.8	4.6	0.8	-0.4	2.1
Cardiovascular Disease	0.2	0.7	1.8	-0.4	-1.4	-0.1
Neuroticism	0.2	0.4	1.0	-0.5	-1.0	-0.1
Average weekly spirits intake	0.2	0.3	0.6	-0.8	-0.2	0.4
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.5	0.9	-0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	0.4	0.4	0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	-0.0	0.2	-0.8
Medication for hormone replacement therapy	0.2	0.3	0.4	-0.6	0.7	0.0
Vitamin and mineral supplements	0.2	0.3	0.7	-0.8	0.4	-0.1
Medication: Co-codamol	0.2	0.3	0.7	-0.3	0.8	0.2
Sitting height	0.2	1.1	1.6	-1.3	1.2	-0.4
Past tobacco smoking	0.2	0.3	0.7	0.4	0.2	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.6	-0.8	0.3	0.6
Worrier / anxious feelings	0.2	0.4	0.8	-0.1	-0.9	-0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.6	-0.3	0.6
Breastfed as a baby	0.2	0.2	0.4	-0.4	-0.6	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.0	0.2	0.3	1.0
Medication: Paracetamol	0.2	0.4	0.8	-0.9	-0.6	0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	-0.5	-0.5	0.4
Pulse wave peak to peak time	0.2	0.2	0.4	0.5	0.6	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.6	0.2	0.7
Number of full sisters	0.2	0.3	0.7	-0.9	-0.4	0.0
Overall health rating	0.2	0.5	1.0	-0.7	-0.0	1.0
Average weekly red wine intake	0.2	0.3	0.7	0.5	0.8	-0.3
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.2	-0.4	-0.8
Wears glasses or contact lenses	0.2	0.2	0.3	-0.5	0.6	0.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.6	0.0	0.8	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	-0.6	-0.4	-0.5
Age started oral contraceptive pill	0.2	0.2	0.6	0.3	-0.2	-0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.3	0.4	-0.6
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.3	0.7	0.3
Pack years of smoking	0.2	0.3	0.8	-0.1	-0.9	0.4
LDL Cholesterol	0.1	0.1	0.2	-0.2	-0.3	0.5
Schizophrenia (2014)	0.1	0.3	0.5	-0.7	-0.1	-0.6
Ulcerative Colitis	0.1	0.2	0.4	-0.1	0.2	0.6
Heel T-Score	0.1	0.4	0.7	0.5	-0.5	0.9
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.1	-0.5	0.2
Fed-up feelings	0.1	0.2	0.4	-0.5	-0.7	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	-0.5	0.5	-0.1
High blood pressure (mother)	0.1	0.1	0.3	0.6	0.1	0.4
Number of incorrect matches in round	0.1	0.2	0.7	0.1	-0.8	0.1
Financial difficulties in last 2 years	0.1	0.1	0.3	0.5	0.3	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.1	0.8	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	0.4	0.8	0.2
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	-0.5	-0.1
Illnesses of mother	0.1	0.2	0.3	-0.1	-0.6	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	-0.0	-0.3	-0.4
Gout (self-reported)	0.1	0.2	0.5	-0.2	0.0	-0.7
Health satisfaction	0.1	0.2	0.5	-0.7	0.1	0.1
Medication: Allopurinol	0.1	0.1	0.3	-0.6	-0.0	-0.3
Comparative height size at age 10	0.1	0.4	0.6	-0.4	-0.6	0.8
Knee pain experienced in last month	0.1	0.2	0.3	0.4	0.5	0.2
Mood swings	0.1	0.2	0.3	-0.6	-0.1	-0.4
Medication: Paracetamol	0.1	0.1	0.3	-0.5	-0.0	0.2
Medication: Lisinopril	0.1	0.2	0.3	-0.5	0.4	-0.2
Ever smoked	0.1	0.2	0.5	-0.2	-0.4	-0.7
Unable to work because of sickness or disability	0.1	0.1	0.3	0.0	0.0	-0.5
Cholesterol lowering medication	0.1	0.2	0.3	-0.5	-0.1	0.5
Pain experienced in last month	0.1	0.2	0.5	-0.2	-0.7	-0.4
Supplements: Calcium	0.1	0.1	0.3	-0.6	-0.2	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.9	2.7	-0.3	1.6	-0.1
Waist Hip Ratio (WHR)	0.0	0.1	0.2	-0.0	0.4	-0.4
Chronotype (morning person)	0.0	0.1	0.1	0.3	0.4	-0.3
Tanning	0.0	0.3	0.4	0.5	0.6	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	-0.2	-0.2	-0.3
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.2	0.2	-0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.2	-0.1	-0.3
Falls in the last year	0.0	0.0	0.1	-0.3	-0.1	-0.1
Standing height	0.0	0.4	0.6	-0.6	0.8	0.4
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	-0.1	0.3	-0.2
Loneliness, isolation	0.0	0.1	0.1	-0.3	0.1	0.3

Hub : Genes

ASCL2

Models

Trait associations