TWAS hub - CD81

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0759	0.0261	5.1e-04	0.009	0.036	0.023	0.036	0.031	2.1e-02	2.0e-05	5.3e-04	1.6e-05	5.6e-05
2	YFS	Blood	0.1091	0.0207	1.7e-16	0.070	0.060	0.076	0.080	0.087	6.9e-22	6.8e-19	8.7e-24	7.0e-25	5.6e-27
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0970	0.0540	4.0e-03	-0.005	0.033	0.008	NA	0.002	9.5e-01	5.2e-03	1.1e-01	NA	2.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Metformin	3.8	5.4	8.1	-2.8	-1.7	-2.3
Ovarian Cancer	3.4	4.5	10.4	-1.3	-1.2	-3.2
Type 2 Diabetes (T2D) (2018)	3.4	6.4	9.4	-3.1	-2.3	-2.1
Breast Cancer	3.3	7.9	18.9	-4.3	0.6	-2.1
Hayfever/allergic rhinitis (self-reported)	3.2	4.2	8.1	2.8	1.3	1.7
Migraine (self-reported)	3.1	3.8	10.1	-0.9	-3.2	-0.7
Qualifications: nursing, teaching	3.0	4.7	13.5	0.3	0.7	3.7
Mouth/teeth dental problems: Mouth ulcers	2.7	4.4	7.5	-2.0	-2.7	-1.3
Tinnitus: Yes, now most or all of the time	2.7	3.2	4.8	1.9	2.2	1.1
Alcohol drinker status: Never	2.7	3.3	5.0	-2.2	0.3	-2.2
Alcohol intake frequency.	2.6	6.1	7.8	-2.8	-1.7	-2.8
Heart attack	2.5	3.2	8.9	-0.7	0.5	-3.0
Systolic blood pressure, automated reading	2.4	7.0	11.8	-3.4	-1.3	-2.8
Townsend deprivation index at recruitment	2.2	3.0	6.9	-0.5	-2.6	-1.4
Heart attack/myocardial infarction (self-reported)	2.2	2.9	7.5	-0.7	0.7	-2.7
Impedance of arm (right)	2.1	10.0	26.8	5.2	1.1	1.4
Time employed in main current job	2.1	2.4	3.8	-1.6	-0.9	-2.0
Qualifications: None of the above	2.0	4.3	8.6	1.4	-1.6	-2.9
Wears glasses or contact lenses	2.0	2.3	3.7	1.9	1.2	1.3
Body Mass Index (BMI) (2010)	1.9	2.6	3.5	1.9	1.5	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	2.9	-1.7	-1.6	-1.2
Average weekly beer plus cider intake	1.9	2.8	6.3	0.4	-1.4	-2.5
Systolic Blood Pressure	1.8	9.2	21.9	-4.7	-1.9	-1.4
Relative age of first facial hair	1.8	3.7	9.9	-3.1	-0.9	-0.7
Length of working week for main job	1.8	2.0	3.3	-1.8	-1.1	-1.2
Number of full brothers	1.8	2.3	3.0	1.3	1.7	1.5
Blood Red Count	1.7	16.7	31.2	-0.6	-4.3	-5.6
Impedance of arm (left)	1.7	8.0	21.8	4.7	0.5	1.3
Medication: Amlodipine	1.7	2.4	7.2	-2.7	-0.1	-0.3
Birth weight	1.7	3.6	7.0	1.9	2.6	0.3
Had major operations	1.7	2.0	5.2	-0.7	2.3	0.7
Ulcerative Colitis (UC)	1.6	3.0	8.6	0.5	-2.9	-0.1
Coronary Artery Disease (CAD)	1.6	1.9	5.3	-0.6	-2.3	0.0
HbA1C	1.6	1.8	3.0	-1.7	-1.4	-0.7
Diabetes (mother)	1.6	2.1	3.2	-1.8	-1.6	-0.7
Exposure to tobacco smoke at home	1.6	1.8	4.1	0.5	-1.0	-2.0
Comparative body size at age 10	1.6	4.4	5.8	-2.4	-1.6	-2.3
Wheeze or whistling in the chest in last year	1.6	2.8	8.1	0.5	0.2	-2.8
Ever had prostate specific antigen (PSA) test	1.6	1.9	3.0	1.2	1.7	-1.1
Mouth/teeth dental problems: Dentures	1.5	2.6	4.4	1.6	0.9	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	8.8	-0.5	2.2	3.0
Forced vital capacity (FVC), Best measure	1.5	5.4	8.3	0.4	2.9	2.8
Exposure to tobacco smoke outside home	1.5	2.0	3.8	1.4	-0.6	-2.0
Medication: Gliclazide	1.5	1.7	3.6	-1.9	-0.4	-1.2
Diastolic blood pressure, automated reading	1.5	4.7	6.2	-2.5	-1.3	-2.5
Commuting to job workplace: Cycle	1.5	1.9	3.6	-1.4	-1.9	0.2
Primary Biliary Cirrhosis	1.4	2.1	2.9	-1.7	-1.5	-0.9
Blood White Count	1.4	10.1	24.3	-2.3	-4.9	-0.8
Chronic bronchitis/emphysema (father)	1.4	1.6	2.5	1.6	0.2	-1.5
Alcohol intake versus 10 years previously	1.4	2.2	5.0	-2.2	-0.2	-1.2
Loneliness, isolation	1.4	2.0	3.5	0.6	1.4	1.9
Verbal and Numeric Reasoning (VNR)	1.3	3.2	6.8	0.4	2.6	1.6
Medication: Ramipril	1.3	1.6	3.1	-0.8	-1.8	-1.1
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	7.2	-0.8	2.1	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	1.8	1.1	1.2	1.4
High blood pressure (mother)	1.1	1.5	4.3	-2.1	0.0	0.6
Forced vital capacity (FVC)	1.1	4.1	7.0	0.0	2.3	2.6
Lung cancer (father)	1.1	1.3	3.0	-1.7	-0.5	-0.9
Shortness of breath walking on level ground	1.1	1.3	3.6	0.3	1.9	0.5
Emphysema/chronic bronchitis	1.1	1.2	2.2	1.2	-1.5	-0.1
Irritable Bowel Disease (IBD)	1.0	2.4	6.7	0.5	-2.6	-0.4
LDL Cholesterol	1.0	1.6	2.6	1.6	1.4	-0.3
Diabetes (self-reported)	1.0	1.6	2.0	-1.1	-1.2	-1.4
Peak expiratory flow (PEF)	1.0	2.2	4.4	-0.5	2.1	1.4
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.1	1.8	0.6	-0.1
Eye problems/disorders: None of the above	1.0	1.2	2.3	-1.1	-1.5	0.3
Average weekly red wine intake	1.0	1.4	4.2	-0.1	0.2	2.0
Hand grip strength (left)	0.9	2.4	6.4	-2.5	-0.5	-0.7
Angina	0.9	1.2	2.7	-1.6	0.9	0.0
Alcohol usually taken with meals	0.9	1.4	2.7	-1.6	-0.3	1.2
Falls in the last year	0.9	1.2	2.5	1.6	0.3	1.0
Age at first live birth	0.9	1.5	3.4	0.2	1.1	1.9
Medication: Blood pressure	0.9	1.6	2.2	-1.3	-1.0	-1.5
Arm predicted mass (right)	0.9	4.7	12.1	-3.5	0.7	-1.2
Diabetes diagnosed by doctor	0.9	1.4	2.0	-1.3	-0.6	-1.4
Mineral and other dietary supplements	0.9	1.3	2.4	-0.3	-1.1	-1.5
Medication: Aspirin	0.9	1.2	2.9	-1.7	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	3.2	-0.0	1.8	1.6
Eye problems/disorders: Glaucoma	0.9	1.1	1.8	0.7	1.1	1.3
Leg fat percentage (left)	0.9	3.1	7.6	0.7	1.1	-2.8
Basal cell carcinoma (self-reported)	0.9	1.1	2.5	1.6	0.9	0.0
Impedance of whole body	0.9	4.6	12.4	3.5	1.2	0.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.7	-1.0	-1.3	0.0
Smoking Status	0.8	1.9	3.5	0.4	1.5	1.9
Allergy or Eczema	0.8	2.2	5.4	2.3	1.0	0.4
Trunk fat percentage	0.8	3.2	5.4	2.3	1.5	-1.4
Age when periods started (menarche)	0.8	2.0	2.6	1.4	1.6	-1.2
Number of live births	0.8	1.1	2.1	0.8	-1.4	-0.7
Noisy workplace	0.8	1.0	1.5	-1.1	-1.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.4	-0.0	1.5	0.6
Medication: Cholesterol lowering	0.8	1.2	2.5	0.2	-1.1	-1.6
Illnesses of mother	0.8	1.0	1.8	1.0	-1.3	0.2
Loud music exposure frequency	0.8	0.8	1.2	-1.1	0.8	0.8
Blood clot in the leg (DVT)	0.8	1.0	2.7	-0.6	-0.0	-1.6
Arm fat-free mass (right)	0.8	4.2	10.0	-3.2	0.9	-1.3
Health satisfaction	0.8	1.0	2.3	0.4	1.5	-0.8
Leg pain on walking	0.8	1.0	3.0	-0.2	1.7	0.1
Medication: Aspirin	0.8	1.0	1.9	-1.4	-0.1	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.6	0.1	-1.6	0.1
Commuting to job workplace: Walk	0.8	0.9	1.6	0.2	-1.2	-1.0
Illnesses of father: None of the above (group 1)	0.8	1.0	2.1	-0.8	-1.5	0.3
Arm predicted mass (left)	0.8	3.9	9.3	-3.0	0.9	-1.2
Schizophrenia vs Biploar Disorder	0.7	0.9	2.2	-1.5	0.7	0.0
Age at First Birth	0.7	1.1	2.7	-1.6	0.7	-0.1
HDL Cholesterol	0.7	1.2	2.9	1.7	0.7	0.3
Blood Eosinophil Count	0.7	5.5	9.9	-0.8	-3.1	-2.4
Hypothyroidism (self reported)	0.7	1.7	4.5	-0.2	2.1	-0.7
Sensitivity / hurt feelings	0.7	1.2	2.2	1.2	-0.1	1.5
Relative age voice broke	0.7	1.1	1.8	-1.2	-1.4	0.1
Taking other prescription medications	0.7	1.1	3.1	0.4	0.2	-1.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.3	-1.1	-0.6	-0.9
Qualifications: CSEs or equivalent	0.7	0.9	2.4	-0.5	1.5	0.4
Sitting height	0.7	4.6	10.0	0.4	3.2	1.9
Hair/balding pattern: Pattern 2	0.7	0.9	1.7	1.3	-0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.2	0.8	-1.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.6	1.2	1.2	0.7
Hair/balding pattern: Pattern 3	0.7	1.0	2.1	-0.6	1.5	0.6
Breastfed as a baby	0.7	0.8	1.8	0.6	-1.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.9	0.4	0.5	1.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.6	0.2	1.9	-0.7
Body fat percentage	0.7	2.7	3.4	1.9	1.3	-1.7
Leg fat percentage (right)	0.7	2.6	5.6	0.8	1.3	-2.4
Qualifications: College or University degree	0.7	2.1	3.5	-1.6	0.5	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.0	-1.4	-0.6	0.4
Suffer from ‘nerves’	0.7	1.1	2.5	-0.2	-0.9	-1.6
Overall health rating	0.7	1.4	2.1	1.5	1.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.9	-1.7	-1.1	-0.6
Ever taken oral contraceptive pill	0.7	0.8	2.2	-0.0	0.5	1.5
Medication: Lisinopril	0.7	0.9	1.9	0.9	1.4	0.2
Arm fat-free mass (left)	0.7	3.5	7.0	-2.6	1.4	-1.2
Ever depressed for a whole week	0.7	0.8	2.1	-0.5	-0.4	-1.5
Fasting Glucose	0.6	0.7	1.7	-1.3	-0.0	-0.5
Cardiovascular Disease	0.6	2.1	4.0	-2.0	-1.1	-1.0
Lung FVC	0.6	3.1	4.7	0.1	2.1	2.2
Hand grip strength (right)	0.6	1.5	3.7	-1.9	-0.8	0.5
Medication: Levothyroxine sodium	0.6	0.9	1.9	-0.2	1.4	-0.9
Trunk fat-free mass	0.6	3.4	9.0	-3.0	0.6	-0.8
Trunk predicted mass	0.6	3.3	8.9	-3.0	0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.2	0.7	0.7	1.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	1.2	-0.2	-0.7
Medication: Ibuprofen	0.6	0.7	2.0	0.1	1.4	-0.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.6	-0.6	1.3	0.2
Long-standing illness, disability or infirmity	0.6	1.0	2.7	0.1	-0.3	-1.6
Ever had bowel cancer screening	0.6	0.7	1.1	1.0	-0.9	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.7	1.3	0.4	-0.3
Number of self-reported non-cancer illnesses	0.6	1.0	1.5	1.0	-0.6	-1.2
Medication: Blood pressure	0.6	1.1	2.8	-1.7	-0.6	-0.1
Illnesses of father: High blood pressure	0.6	0.8	1.2	-0.8	-0.6	-1.1
Fractured/broken bones in last 5 years	0.6	0.7	1.7	-1.3	-0.6	0.1
Alcohol drinker status: Previous	0.6	0.7	1.6	-0.5	0.5	-1.3
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.1	-1.4	1.5	0.7
Crohns Disease (2017)	0.5	1.1	2.5	0.6	-1.6	-0.7
Mean Putamen Volume	0.5	0.6	1.3	0.7	1.1	0.1
BMI	0.5	3.0	6.3	-1.7	-0.2	-2.5
Waist Hip Ratio (WHR)	0.5	2.2	5.6	2.4	0.7	-0.6
Lung FEV1/FVC ratio	0.5	2.6	5.1	-2.3	-1.6	0.0
Average weekly spirits intake	0.5	0.7	1.4	1.2	0.7	0.4
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	-0.0	-1.1	0.7
Serious illness, injury or assault to yourself	0.5	0.6	1.8	0.2	0.3	-1.3
Multivitamins +/- minerals	0.5	0.6	1.5	-0.1	-1.2	-0.5
Stomach or abdominal pain in last month	0.5	0.6	1.5	0.5	1.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	0.3	-1.0	-0.9
Trunk fat mass	0.5	2.1	2.6	1.3	1.4	-1.6
Waist circumference	0.5	1.8	2.4	1.1	1.4	-1.6
Nervous feelings	0.5	0.9	2.5	1.6	-0.3	0.4
Hearing difficulty/problems with background noise	0.5	0.7	1.0	-1.0	0.8	0.8
Had other major operations	0.5	0.6	1.3	0.2	-0.6	-1.2
Arm fat percentage (right)	0.5	1.8	3.5	1.9	1.2	-0.8
Happiness	0.5	0.7	1.5	-0.2	1.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.8	-0.2	1.3	-0.4
Hair/balding pattern: Pattern 4	0.5	1.3	1.8	0.4	-1.4	1.4
Angina (self-reported)	0.5	0.7	1.3	-1.2	0.8	0.3
Whole body fat mass	0.5	2.1	3.9	0.8	1.3	-2.0
Leg fat mass (right)	0.5	1.9	3.8	0.4	1.4	-1.9
Illnesses of father: Heart disease	0.5	0.7	1.3	0.8	1.1	-0.2
Whole body fat-free mass	0.5	2.7	7.4	-2.7	0.6	-0.6
Commuting to job workplace: Public transport	0.5	0.6	1.2	-0.3	-1.1	-0.7
Myopia	0.5	0.8	2.0	0.5	-1.4	-0.2
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.4	1.6	-0.0	1.2
Leg fat mass (left)	0.5	2.0	4.4	0.4	1.3	-2.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.5	0.2	1.2	0.2
Reaction Time	0.4	0.8	1.8	0.0	-0.7	-1.4
Neuroticism (2016)	0.4	0.6	1.3	0.6	0.1	1.2
Heel T-Score	0.4	3.0	5.7	-2.4	-0.9	-1.6
Medication for hormone replacement therapy	0.4	0.5	0.6	0.8	0.5	0.8
Vitamin and mineral supplements	0.4	0.5	1.4	0.3	1.2	0.1
Supplements: Zinc	0.4	0.4	1.2	-1.1	-0.2	-0.0
Severe depression (siblings)	0.4	0.4	1.0	1.0	-0.1	-0.5
Impedance of leg (right)	0.4	1.8	3.7	1.9	1.3	-0.3
Current tobacco smoking	0.4	0.6	1.2	0.4	0.8	1.1
Average weekly fortified wine intake	0.4	0.5	1.3	-1.2	-0.2	-0.2
Impedance of leg (left)	0.4	2.2	3.0	1.7	1.5	-1.2
Mouth/teeth dental problems	0.4	0.7	1.7	0.3	0.5	-1.3
Fluid intelligence score	0.4	0.9	2.6	0.0	1.6	0.3
Hip circumference	0.4	1.6	4.2	0.5	2.1	-0.6
Pulse rate	0.4	0.6	1.2	-1.1	-0.4	-0.7
Pulse wave reflection index	0.4	0.6	1.1	0.7	-1.1	0.3
Medication: Paracetamol	0.4	0.7	1.1	0.9	0.4	-1.0
Glaucoma (self-reported)	0.4	0.5	1.3	0.3	-0.2	1.1
Medication for pain relief, constipation, heartburn	0.4	0.6	1.2	-0.2	-0.8	1.1
Mean time to correctly identify matches	0.4	0.7	1.0	0.2	-1.0	-1.0
Hypertension (Self-reported)	0.4	1.0	1.6	-1.3	-0.8	-0.9
Breast cancer (self-reported)	0.4	0.5	0.9	1.0	0.7	-0.0
Whole body water mass	0.4	2.5	6.7	-2.6	0.7	-0.6
Hearing aid user	0.4	0.5	0.8	-0.8	-0.9	-0.1
Mother’s age at death	0.4	0.5	1.1	-1.1	0.6	0.4
Financial situation satisfaction	0.4	0.5	0.9	-0.4	1.0	-0.6
Basal metabolic rate	0.4	2.0	4.8	-2.2	0.8	-0.8
Irritability	0.4	0.7	1.0	-0.3	1.0	1.0
Age started oral contraceptive pill	0.4	0.5	1.2	0.2	-1.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.6	0.0	-1.1
Heart disease (siblings)	0.4	0.5	1.0	0.3	0.6	1.0
Pack years of smoking	0.4	0.5	0.8	0.9	-0.8	-0.5
Bipolar Disorder (2018)	0.3	0.5	1.4	1.2	0.2	0.0
Depression (Nagel 2018)	0.3	0.5	1.2	1.1	-0.6	-0.0
Triglycerides	0.3	0.5	1.3	-0.5	-1.1	0.2
Blood Platelet Count	0.3	2.9	8.1	0.3	-2.8	-0.8
Number of treatments/medications taken	0.3	0.6	1.6	-0.1	0.1	-1.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	-0.8	0.7	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.6	0.0	-0.7	0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.4	0.6	-0.6	0.5
Supplements: Glucosamine	0.3	0.3	0.8	0.1	0.5	0.9
Medication: Atenolol	0.3	0.4	0.8	-0.9	0.5	-0.4
Body mass index (BMI)	0.3	1.2	3.2	-0.7	0.2	-1.8
Number of incorrect matches in round	0.3	0.5	1.0	0.1	-1.0	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.8	0.9	0.7	0.1
Financial difficulties in last 2 years	0.3	0.4	0.9	-0.6	0.2	-0.9
Weight	0.3	1.5	2.7	-0.6	1.2	-1.6
Worrier / anxious feelings	0.3	0.6	1.5	0.6	-1.2	0.2
Depression (self-reported)	0.3	0.3	0.6	0.7	-0.1	-0.7
Medication: Lansoprazole	0.3	0.4	1.0	-1.0	-0.2	-0.4
Prospective memory result	0.3	0.4	0.9	0.9	-0.6	0.2
Arm fat mass (right)	0.3	1.1	1.5	0.8	1.2	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	-0.9	-0.6	-0.4
Birth weight of first child	0.3	0.6	1.3	-0.7	-0.2	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	0.9	0.7	0.1
High blood pressure (siblings)	0.3	0.5	1.3	-1.1	0.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	-0.1	0.7	-0.9
Pulse wave peak to peak time	0.3	0.3	0.7	0.5	0.2	-0.9
Neck or shoulder pain in last month	0.3	0.5	0.8	0.9	0.8	-0.3
Medication: Allopurinol	0.3	0.4	0.6	0.1	0.8	-0.7
Medication: Omeprazole	0.3	0.4	1.0	-0.4	1.0	-0.2
Pulse rate, automated reading	0.3	0.9	1.2	1.0	1.1	0.7
Number of full sisters	0.3	0.4	1.0	1.0	0.1	-0.1
Chest pain or discomfort	0.3	0.5	1.2	0.3	1.1	0.2
Arm fat percentage (left)	0.3	1.4	2.8	1.7	0.9	-0.8
Friendships satisfaction	0.3	0.4	1.0	-0.4	1.0	0.0
Back pain experienced in last month	0.3	0.4	0.8	0.9	0.1	-0.6
Smoking status: Current	0.3	0.5	1.2	0.2	0.4	1.1
Guilty feelings	0.3	0.4	1.0	1.0	-0.3	-0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	-0.2	-1.0	-0.1
High cholesterol (Self-reported)	0.3	0.5	1.1	-0.2	-1.0	-0.5
Number of operations (self-reported)	0.3	0.5	1.2	-0.3	-0.3	-1.1
Pain experienced in last month	0.3	0.5	0.9	-0.9	-0.8	-0.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.4	0.6	-0.3
Prostate Cancer	0.2	0.4	0.6	0.1	0.7	-0.7
Schizophrenia (2014)	0.2	0.4	0.8	-0.5	0.9	0.0
Ulcerative Colitis	0.2	0.3	0.6	-0.6	-0.8	0.0
Height	0.2	3.9	9.9	0.8	3.1	1.0
Respiratory disease	0.2	0.5	0.7	0.7	0.8	-0.6
Neuroticism	0.2	0.4	0.7	0.0	-0.6	0.9
Hair Pigment	0.2	5.2	8.1	-2.3	-2.9	-1.5
Hearing difficulty/problems: Yes	0.2	0.4	0.5	-0.7	0.7	-0.4
Medication: Co-codamol	0.2	0.2	0.5	0.3	0.7	-0.1
Diabetes (father)	0.2	0.3	0.6	-0.3	-0.4	0.8
Pack years adult smoking proportion	0.2	0.4	0.5	0.6	-0.7	-0.4
Leg fat-free mass (left)	0.2	0.9	2.4	-1.5	0.7	-0.1
Maternal smoking around birth	0.2	0.2	0.5	-0.3	-0.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	0.1	-0.3	0.8
High blood pressure	0.2	0.6	1.1	-1.0	-0.3	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	1.0	0.5	0.6
Leg predicted mass (left)	0.2	1.0	2.5	-1.6	0.7	-0.1
Had menopause	0.2	0.2	0.6	0.0	0.3	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	-0.0	1.0	-0.0
Illnesses of siblings	0.2	0.3	0.7	0.4	0.8	-0.2
Neuroticism score	0.2	0.5	0.8	0.9	0.3	0.7
Father’s age at death	0.2	0.3	0.4	0.7	0.3	0.5
Asthma	0.2	0.3	0.7	-0.0	0.8	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.4	0.1	0.7
Tense / ‘highly strung’	0.2	0.4	0.7	0.7	0.0	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.1	0.8	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	-0.2	-0.4	-0.7
Number of children fathered	0.2	0.3	0.7	0.8	-0.0	0.3
Heart disease (mother)	0.2	0.3	0.8	-0.3	0.9	-0.1
Age at last live birth	0.2	0.3	0.6	0.1	0.8	0.5
Family relationship satisfaction	0.2	0.2	0.4	0.4	0.1	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.6	-0.3	0.3
Supplements: Vitamin C	0.2	0.2	0.4	-0.5	-0.6	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.2	0.7	-0.1
Leg fat-free mass (right)	0.2	1.3	3.5	-1.9	0.5	-0.4
Mood swings	0.2	0.4	0.8	0.9	0.5	-0.2
Eye problems/disorders: Cataract	0.2	0.3	0.5	0.2	0.7	-0.6
Medication for cholesterol	0.2	0.3	0.4	0.6	-0.1	0.6
Osteoarthritis (self-reported)	0.2	0.3	0.9	0.3	-0.9	-0.1
Leg predicted mass (right)	0.2	1.3	3.4	-1.8	0.5	-0.4
Arm fat mass (left)	0.2	1.0	1.4	0.6	1.1	-1.2
Miserableness	0.2	0.3	0.5	0.4	0.2	0.7
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.8	-0.3	0.3
Medication: Paracetamol	0.2	0.3	0.7	0.1	0.8	-0.5
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.0	0.0	-0.8
Supplements: Calcium	0.2	0.2	0.4	-0.0	0.7	-0.4
Schizophrenia (2018)	0.1	0.1	0.3	-0.6	0.2	0.0
Worry (Nagel 2018)	0.1	0.3	0.5	0.6	-0.7	0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.2	0.5	0.2
Crohns Disease (2012)	0.1	0.2	0.6	0.3	-0.8	0.1
Rheumatoid Arthritis	0.1	0.2	0.5	-0.2	-0.7	0.0
Tanning	0.1	1.1	2.2	1.5	1.0	0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.6	-0.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.4	0.4	0.0
Fed-up feelings	0.1	0.1	0.2	-0.5	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	0.1	0.8	-0.4
Past tobacco smoking	0.1	0.3	0.7	0.3	0.0	-0.8
Allergy	0.1	0.2	0.5	-0.7	-0.5	0.2
Pain all over the body in last month	0.1	0.1	0.2	0.1	-0.4	0.5
Medication: Simvastatin	0.1	0.1	0.1	-0.3	-0.3	-0.4
Standing height	0.1	1.4	4.1	0.1	2.0	-0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	-0.4	-0.6	0.2
Worry too long after embarrassment	0.1	0.2	0.5	0.4	0.0	0.7
Medication: Seretide 50 evohaler	0.1	0.2	0.2	-0.3	-0.4	-0.4
Comparative height size at age 10	0.1	0.8	1.5	1.2	-0.2	-1.0
Knee pain experienced in last month	0.1	0.2	0.4	0.7	-0.2	0.2
Smoking status: Previous	0.1	0.2	0.5	-0.1	0.1	0.7
Asthma (self-reported)	0.1	0.2	0.4	0.0	0.6	-0.6
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.4	-0.3	0.5
Medication: Atorvastatin	0.1	0.1	0.3	0.2	-0.1	-0.5
Ever smoked	0.1	0.2	0.4	-0.5	-0.3	0.6
Cholesterol lowering medication	0.1	0.1	0.2	-0.3	0.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.5	0.3	-0.2
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.2	0.0	0.0
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	0.1	0.3	0.2
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.5	-0.2	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	0.0	0.1	0.1	0.2	0.4	-0.1
Chronotype (morning person)	0.0	0.1	0.3	0.0	0.5	0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	-0.4	0.2	0.3
Headache pain in last month	0.0	0.1	0.1	0.2	0.3	-0.1
Gout (self-reported)	0.0	0.0	0.0	-0.1	-0.0	-0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.1	0.3	-0.0
Average weekly champagne plus white wine intake	0.0	0.0	0.0	-0.1	0.2	-0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.2	-0.0	0.0
Risk taking	0.0	0.0	0.0	0.2	0.1	-0.2

Hub : Genes

CD81

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Trait associations