Best TWAS P=2.26e-29 · Best GWAS P=4.2e-32 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNAJC24 | 0.04 | 0.01 | blup | 279 | 0.02 | 4.0e-03 | 6.7 | -7.2 | 5.3e-13 | -0.17 | 0.43 | 0.04 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | ELP4 | 0.07 | 0.04 | lasso | 3 | 0.04 | 5.8e-04 | 6.6 | 6.7 | 2.7e-11 | 0.19 | 0.84 | 0.04 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | ELP4 | 0.10 | 0.12 | enet | 7 | 0.12 | 8.8e-07 | 6.6 | 6.7 | 3.0e-11 | 0.19 | 0.90 | 0.04 | FALSE |
| 4 | GTEx | Adrenal Gland | MPPED2 | 0.43 | 0.33 | lasso | 9 | 0.30 | 1.5e-11 | -5.4 | -5.8 | 9.1e-09 | -0.03 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Artery Tibial | DNAJC24 | 0.05 | 0.05 | enet | 13 | 0.03 | 2.6e-03 | 6.7 | -5.6 | 2.0e-08 | -0.15 | 0.47 | 0.02 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | ELP4 | 0.09 | 0.04 | lasso | 5 | 0.05 | 1.8e-03 | 7.7 | 9.6 | 5.2e-22 | 0.22 | 0.02 | 0.86 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | IMMP1L | 0.08 | 0.01 | enet | 18 | 0.00 | 2.1e-01 | -8.5 | 8.8 | 1.5e-18 | 0.21 | 0.04 | 0.74 | TRUE |
| 8 | GTEx | Breast Mammary Tissue (Male) | IMMP1L | 0.15 | 0.01 | lasso | 7 | 0.00 | 4.1e-01 | 7.7 | 7.1 | 1.3e-12 | 0.21 | 0.04 | 0.22 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | ELP4 | 0.26 | 0.12 | lasso | 5 | 0.07 | 5.2e-03 | -10.4 | 10.2 | 2.0e-24 | 0.24 | 0.01 | 0.96 | TRUE |
| 10 | GTEx | Cells Transformed fibroblasts | RP1-65P5.3 | 0.18 | 0.08 | enet | 15 | 0.12 | 2.5e-09 | 3.5 | -5.7 | 1.5e-08 | -0.07 | 0.99 | 0.01 | TRUE |
| 11 | GTEx | Colon Transverse | DNAJC24 | 0.07 | 0.02 | enet | 13 | 0.05 | 2.5e-03 | 2.2 | -5.2 | 1.9e-07 | -0.08 | 0.12 | 0.07 | TRUE |
| 12 | GTEx | Muscle Skeletal | MPPED2 | 0.09 | 0.07 | lasso | 3 | 0.06 | 2.4e-06 | -9.3 | 8.2 | 1.6e-16 | 0.18 | 0.99 | 0.00 | FALSE |
| 13 | GTEx | Muscle Skeletal | DNAJC24 | 0.08 | 0.06 | enet | 12 | 0.05 | 9.1e-06 | 6.5 | -5.5 | 3.7e-08 | -0.16 | 0.99 | 0.00 | FALSE |
| 14 | GTEx | Nerve Tibial | MPPED2 | 0.07 | 0.00 | enet | 7 | 0.01 | 8.7e-02 | -11.3 | -9.1 | 1.2e-19 | -0.13 | 0.16 | 0.16 | FALSE |
| 15 | GTEx | Nerve Tibial | DNAJC24 | 0.05 | 0.04 | lasso | 4 | 0.02 | 2.0e-02 | 6.7 | -6.5 | 9.6e-11 | -0.18 | 0.26 | 0.04 | FALSE |
| 16 | GTEx | Testis | MPPED2 | 0.18 | 0.17 | enet | 15 | 0.17 | 6.9e-08 | -10.9 | -11.3 | 2.3e-29 | -0.20 | 0.85 | 0.14 | TRUE |
| 17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DNAJC24 | 0.05 | 0.01 | blup | 31 | 0.01 | 9.4e-02 | 6.5 | 6.4 | 1.7e-10 | 0.21 | 0.02 | 0.11 | FALSE |
| 18 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | IMMP1L | 0.11 | 0.02 | blup | 40 | 0.03 | 1.0e-02 | 4.8 | 8.0 | 1.3e-15 | 0.19 | 0.02 | 0.56 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DNAJC24 | 0.05 | 0.02 | lasso | 3 | 0.02 | 6.7e-03 | 6.7 | 6.7 | 2.5e-11 | 0.19 | 0.12 | 0.08 | TRUE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ELP4 | 0.05 | 0.00 | blup | 106 | 0.02 | 5.6e-03 | -3.3 | 5.5 | 4.5e-08 | 0.11 | 0.02 | 0.38 | TRUE |
| 21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IMMP1L | 0.04 | 0.02 | lasso | 1 | 0.01 | 1.1e-02 | 6.6 | 6.6 | 4.5e-11 | 0.19 | 0.02 | 0.08 | FALSE |
| 22 | The Cancer Genome Atlas | Lung Adenocarcinoma | DNAJC24 | 0.03 | 0.02 | blup | 31 | 0.01 | 3.8e-02 | 6.6 | 6.8 | 9.9e-12 | 0.21 | 0.05 | 0.11 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Adenocarcinoma | IMMP1L | 0.04 | 0.02 | blup | 40 | 0.02 | 2.0e-03 | 4.7 | 7.0 | 1.8e-12 | 0.16 | 0.08 | 0.37 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ELP4 | 0.03 | 0.03 | enet | 3 | 0.03 | 9.7e-04 | -6.2 | 6.0 | 1.4e-09 | 0.07 | 0.07 | 0.71 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IMMP1L | 0.05 | 0.01 | blup | 40 | 0.00 | 1.8e-01 | -8.6 | 9.4 | 7.4e-21 | 0.22 | 0.00 | 0.71 | TRUE |