Hub : Genes

DNAJC24

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0380	0.0210	7.5e-04	0.011	0.016	0.013	0.015	0.005	1.6e-02	0.00400	9.2e-03	5.5e-03	7.2e-02
2	GTEx	Artery Tibial	0.0460	0.0257	6.3e-03	0.047	NA	0.028	NA	0.027	1.4e-04	NA	2.6e-03	NA	3.2e-03
3	GTEx	Colon Transverse	0.0740	0.0410	9.3e-03	0.019	NA	0.048	NA	0.016	4.1e-02	NA	2.5e-03	NA	5.4e-02
4	GTEx	Muscle Skeletal	0.0804	0.0330	6.0e-06	0.060	NA	0.051	NA	0.050	1.5e-06	NA	9.1e-06	NA	1.0e-05
5	GTEx	Nerve Tibial	0.0473	0.0240	3.7e-03	0.036	NA	0.000	NA	0.017	1.3e-03	NA	3.3e-01	NA	2.0e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.0553	0.0257	3.8e-05	0.028	0.038	0.029	0.039	0.036	1.6e-04	0.00001	1.0e-04	7.8e-06	1.9e-05
7	TCGA	Bladder Urothelial Carcinoma	0.0460	0.0300	7.1e-03	0.015	0.006	-0.002	NA	0.003	1.8e-02	0.09400	4.7e-01	NA	1.6e-01
8	TCGA	Breast Invasive Carcinoma	0.0196	0.0144	6.8e-03	0.007	0.007	0.005	NA	0.002	1.0e-02	0.00920	3.0e-02	NA	1.1e-01
9	TCGA	Cervical Squamous Cell Carcinoma	0.0850	0.0530	3.9e-03	0.018	0.025	0.033	NA	0.024	4.5e-02	0.02100	9.7e-03	NA	2.2e-02
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0469	0.0251	3.3e-04	0.021	0.015	0.010	NA	0.015	1.9e-03	0.00800	2.4e-02	NA	6.7e-03
11	TCGA	Lung Adenocarcinoma	0.0319	0.0194	1.4e-03	0.018	0.008	0.005	NA	0.007	3.3e-03	0.03800	6.9e-02	NA	4.4e-02
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.0630	0.0420	1.4e-03	0.007	0.000	-0.004	NA	-0.001	9.7e-02	0.32000	9.7e-01	NA	3.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.3	0.4	1.2	-0.9	-1.1	0.6	-0.0	-0.7	-0.5	0.5	0.2	-0.4	0.7	1.0	-0.1
Bipolar Disorder or Schizophrenia	1.2	2.9	6.3	0.8	1.3	1.3	1.6	1.3	-2.5	-1.6	-2.4	-2.3	-1.2	-1.0	-2.2
Depressed Affect (Nagel 2018)	0.2	0.4	2.4	1.6	-0.7	-0.6	-0.5	-0.2	0.4	0.2	0.2	0.7	0.3	-0.0	0.4
Depression (Nagel 2018)	0.5	0.7	1.4	0.9	0.5	-0.0	0.9	0.7	-0.8	-0.9	-1.2	-0.9	-0.9	-0.8	-1.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.1	0.7	0.2	0.9	-0.1	0.4	0.7	0.3	1.2	1.4	-0.1	-0.4	1.1
Neuroticism (Nagel 2018)	1.9	4.4	9.1	1.4	-2.4	-1.9	-2.2	-1.4	2.1	2.0	2.5	3.0	1.6	1.2	2.7
Schizophrenia (2018)	2.7	5.6	10.1	1.7	2.5	1.3	2.1	2.2	-2.8	-2.4	-3.2	-2.6	-2.2	-2.1	-2.7
Schizophrenia vs Biploar Disorder	2.4	3.1	5.8	1.9	2.4	1.2	1.8	1.9	-1.5	-1.8	-1.7	-1.7	-1.9	-1.9	-1.4
Worry (Nagel 2018)	1.1	2.4	5.6	2.2	-1.5	-1.3	-1.5	-0.3	1.1	1.3	1.9	2.4	0.7	0.3	2.2
Alzheimer’s Disease (in mother)	1.5	1.7	6.2	1.3	1.4	2.5	1.4	1.1	-1.2	-1.2	-1.1	-1.2	-1.0	-1.0	-0.7
Alzheimer’s Disease (in father)	2.0	2.2	8.3	0.1	1.4	1.0	1.0	0.6	-2.9	-0.9	-2.0	-2.3	-0.5	-0.4	-1.7
Alzheimer’s Disease (including proxy)	1.2	1.7	5.6	0.7	1.6	1.5	1.0	0.7	-2.4	-0.9	-1.5	-2.0	-0.6	-0.5	-1.0
Crohns Disease (2017)	0.1	0.3	1.4	-0.3	0.4	-1.2	-0.3	-0.5	0.9	-0.1	-0.8	-0.3	0.0	0.4	-0.2
Irritable Bowel Disease (IBD)	0.9	2.2	4.1	-1.4	-0.9	-1.4	-1.6	-1.9	2.0	1.4	0.8	1.2	1.4	1.8	1.4
Ulcerative Colitis (UC)	1.6	2.9	5.4	-1.5	-1.2	-0.8	-1.8	-2.1	2.3	1.8	1.5	1.5	1.7	2.0	1.9
Major Depression (MDD)	0.9	1.0	5.0	2.2	1.3	0.5	0.6	1.1	-0.0	-0.9	-0.4	-0.6	-1.2	-1.1	-0.2
Reaction Time	4.1	7.8	13.7	3.5	3.1	3.7	3.1	3.0	-1.5	-2.9	-2.1	-1.2	-3.2	-3.3	-1.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	0.9	0.7	0.2	-0.3	0.3	0.7	0.3	1.0	1.3	-0.1	-0.3	1.2
Breast Cancer	0.1	0.2	0.8	0.3	0.3	-0.3	-0.2	0.4	0.9	-0.1	0.2	0.2	-0.5	-0.4	0.4
Ovarian Cancer	0.3	0.4	1.3	0.2	-0.3	-0.5	-1.0	-0.3	0.0	0.7	0.6	1.1	0.5	0.2	1.0
Prostate Cancer	0.0	0.0	0.1	-0.2	-0.0	-0.0	-0.4	-0.0	-0.3	0.1	-0.0	0.3	-0.0	-0.1	-0.1
Age at First Birth	0.6	0.9	1.7	-0.7	-1.1	-1.0	-0.8	-1.0	1.3	1.0	0.9	0.8	0.8	1.0	0.9
Bipolar Disorder (2011)	1.3	1.3	3.6	-1.9	-1.3	-0.7	-0.9	-1.6	0.8	1.0	0.4	0.5	1.2	1.5	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.7	0.3	0.4	0.6	-0.0	-0.5	-0.6	-0.9	-1.0	-0.2	-0.1	-1.0
Coronary Artery Disease (CAD)	0.4	0.5	1.6	-0.5	-1.3	-0.6	-0.7	-0.8	0.4	0.7	0.4	0.6	0.7	0.6	0.6
Crohns Disease (2012)	0.1	0.2	0.6	-0.3	-0.4	-0.8	-0.6	-0.6	0.8	0.1	-0.4	0.6	0.3	0.3	-0.1
Mean Putamen Volume	0.2	0.2	0.8	0.1	-0.8	0.0	-0.0	0.5	-0.2	0.1	0.9	0.5	-0.1	-0.3	0.6
Fasting Glucose	2.2	2.6	4.8	-2.0	-1.7	-2.1	-1.5	-2.2	0.7	1.9	0.9	0.3	1.4	2.1	1.0
HbA1C	0.2	0.2	0.6	-0.8	-0.2	0.0	-0.6	-0.5	-0.6	0.6	0.3	0.1	0.4	0.5	0.3
HDL Cholesterol	0.7	1.2	2.0	1.0	1.4	1.2	1.3	1.4	-0.8	-0.9	-0.7	-1.0	-1.2	-1.1	-0.8
LDL Cholesterol	0.7	1.1	3.0	-1.7	-1.5	-0.7	-1.0	-1.2	-0.1	1.0	0.0	0.3	1.3	1.2	0.3
Lupus	0.2	0.3	1.4	-0.5	-0.3	-1.2	-1.0	-0.6	-0.3	0.3	-0.5	0.3	0.6	0.3	-0.1
Neuroticism (2016)	2.3	3.3	8.4	0.1	-1.8	-2.9	-2.2	-1.4	1.8	1.7	1.4	2.5	1.5	1.1	1.9
Primary Biliary Cirrhosis	0.6	0.8	2.6	-1.6	-1.3	0.1	-0.7	-1.2	0.4	0.8	0.6	0.6	1.1	1.0	0.4
Rheumatoid Arthritis	0.4	0.5	2.2	0.7	1.2	1.1	0.2	-0.0	1.5	-0.5	-0.3	0.4	-0.4	-0.3	0.1
Schizophrenia (2014)	1.8	4.0	6.7	1.5	2.2	1.3	2.0	1.7	-2.0	-2.0	-2.6	-2.3	-1.8	-1.6	-2.4
Triglycerides	0.2	0.3	0.7	-0.6	-0.4	-0.8	-0.7	-0.7	-0.1	0.5	0.1	-0.0	0.8	0.8	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.6	-0.3	-0.2	-0.1	0.6	-0.2	-1.2	-0.2	-0.7	-1.0	0.1	0.2	-0.9
Ulcerative Colitis	2.1	3.0	3.9	-1.6	-1.7	-1.0	-1.9	-1.9	1.5	2.0	1.7	1.8	1.8	1.9	1.8
Blood Eosinophil Count	0.8	6.5	11.3	3.4	3.2	2.9	2.7	2.7	-2.0	-2.5	-1.6	-1.9	-2.7	-2.7	-1.6
Blood Platelet Count	0.0	0.3	1.2	1.1	-0.0	0.7	-0.0	0.4	-0.7	0.3	1.0	0.6	-0.0	-0.2	0.6
Blood Red Count	3.0	28.9	52.1	-7.2	-5.6	-5.2	-5.5	-6.5	2.0	6.4	3.3	2.9	6.7	6.8	3.0
Blood White Count	0.3	2.2	4.2	-1.4	-1.5	-1.2	-1.6	-1.7	0.3	2.0	1.2	0.7	1.9	2.0	1.2
Heel T-Score	0.6	4.4	9.1	3.0	2.2	2.9	1.9	2.1	-1.1	-2.3	-1.5	-1.0	-2.3	-2.4	-1.1
BMI	0.5	3.0	12.3	-0.7	1.5	3.5	2.1	0.7	-0.7	-1.5	-1.9	-1.0	-1.1	-1.1	-2.4
Height	1.0	18.4	31.6	4.7	4.3	3.7	4.4	5.0	-1.8	-5.2	-3.7	-2.2	-5.3	-5.6	-3.6
Waist Hip Ratio (WHR)	0.3	1.4	8.3	-0.8	-1.2	-2.9	-1.2	-0.9	-0.0	1.0	0.4	0.7	1.0	1.0	0.5
Systolic Blood Pressure	1.5	7.3	22.1	4.7	2.1	1.8	2.7	3.4	-1.2	-2.8	-1.9	-0.9	-3.1	-3.5	-1.9
Smoking Status	2.1	5.1	7.8	2.7	2.5	1.2	2.6	2.3	-0.1	-2.8	-2.1	-2.1	-2.8	-2.5	-1.9
Allergy or Eczema	1.0	2.5	3.6	-1.6	-1.1	-1.8	-1.9	-1.8	1.6	1.5	1.0	1.9	1.6	1.5	1.6
Cardiovascular Disease	0.4	1.4	4.5	2.1	1.3	1.3	0.8	1.1	1.4	-1.2	-0.2	0.5	-1.4	-1.4	-0.1
Hypothyroidism (self reported)	0.4	0.9	2.2	0.5	0.7	0.2	0.9	0.8	-0.7	-1.2	-1.3	-1.1	-0.9	-0.9	-1.5
Respiratory disease	1.6	3.5	4.9	-2.1	-1.6	-2.0	-2.2	-2.1	1.7	1.8	1.4	1.8	2.0	2.0	1.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	2.2	-1.5	-0.2	-0.8	-0.2	-0.3	-0.6	0.1	-0.4	-0.7	0.4	0.3	-0.4
Lung FEV1/FVC ratio	1.1	5.4	8.8	3.0	1.9	2.8	2.8	2.4	-1.3	-2.4	-1.8	-2.2	-2.5	-2.3	-1.9
Lung FVC	0.5	2.5	5.0	0.2	0.5	1.8	2.2	1.3	-1.2	-1.7	-2.0	-2.1	-1.5	-1.1	-1.9
Neuroticism	1.4	3.5	7.6	2.0	-2.1	-1.6	-1.9	-0.8	1.9	1.6	2.3	2.8	1.1	0.8	2.5
Chronotype (morning person)	0.4	0.9	2.5	0.8	-0.3	-0.5	-0.9	-0.5	1.6	0.6	1.2	1.4	0.4	0.3	1.4
Hair Pigment	0.0	0.9	1.6	-0.1	-1.3	0.5	-0.8	-1.2	0.9	0.9	0.8	1.3	1.1	1.0	0.9
Tanning	0.1	1.7	3.5	-1.4	-0.5	-0.7	-1.3	-1.4	1.9	1.3	1.5	0.9	1.3	1.3	1.5
Hand grip strength (left)	0.5	1.4	4.3	-0.2	0.9	1.8	1.5	0.7	-1.4	-0.7	-0.9	-2.1	-0.5	-0.2	-1.3
Number of treatments/medications taken	0.3	0.6	1.6	1.0	-0.1	-0.7	-1.3	-0.3	0.6	0.5	0.8	1.2	0.4	0.1	1.2
Average weekly spirits intake	6.4	7.9	8.9	-2.6	-2.8	-2.7	-2.8	-2.9	3.0	3.0	2.8	2.8	2.8	2.8	2.7
Sensitivity / hurt feelings	5.5	9.4	15.4	-2.5	-3.9	-3.0	-3.2	-3.3	1.7	3.4	2.8	2.8	3.5	3.3	2.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	1.1	0.0	-0.6	0.4	0.5	-0.1	-0.7	-0.7	0.0	-0.6	-0.8	-0.5
Hearing difficulty/problems: Yes	0.2	0.3	1.9	-0.2	0.0	0.8	-0.2	-0.2	-1.4	0.0	-0.6	-0.1	0.3	0.1	-0.4
Relative age of first facial hair	0.9	1.8	3.1	1.7	1.0	1.5	1.7	1.4	0.5	-1.6	-1.0	-1.1	-1.7	-1.4	-1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	1.4	-0.1	-0.4	-1.2	-0.7	-0.4	-0.5	0.1	-0.2	0.5	0.3	0.1	0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.5	0.2	0.8	0.4	1.2	0.9	0.3	-1.1	-1.1	-0.2	-1.1	-1.2	-1.2
Ever had hysterectomy (womb removed)	0.0	0.1	0.3	-0.1	-0.0	-0.3	0.2	0.1	0.5	-0.2	0.2	-0.3	-0.2	0.0	0.1
Systolic blood pressure, automated reading	2.1	6.0	11.2	3.3	2.0	1.9	2.5	2.8	-2.4	-2.5	-2.3	-1.2	-2.5	-3.0	-2.3
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.2	-1.0	-1.2	-1.8	-1.4	-0.7	-1.5	1.0	0.5	0.2	1.1	0.8	0.4
Angina	0.1	0.1	0.3	0.3	0.1	-0.3	-0.5	-0.5	0.2	0.2	-0.4	0.3	0.4	0.3	-0.3
Medication for hormone replacement therapy	0.8	0.9	1.8	-0.2	0.8	0.9	1.3	0.8	-0.8	-1.1	-1.1	-1.1	-0.9	-0.8	-1.4
Vitamin and mineral supplements	1.5	2.0	4.0	1.7	1.2	2.0	1.8	1.5	-0.5	-1.3	-1.1	-1.1	-1.6	-1.3	-1.1
Supplements: Zinc	0.6	0.7	1.8	-1.1	0.0	0.5	0.4	-0.2	-1.4	-0.4	-1.2	-1.2	0.0	0.1	-1.3
Medication: Co-codamol	5.4	6.3	9.7	3.1	2.5	1.8	2.2	2.5	-1.8	-2.8	-2.9	-1.9	-2.6	-2.9	-2.6
Medication: Metformin	0.5	0.7	4.4	-0.2	0.5	-0.8	0.1	0.3	-2.1	-0.2	-1.1	-1.1	-0.1	-0.3	-1.0
Diabetes (father)	0.4	0.5	2.3	-1.5	-0.8	1.1	0.3	-0.5	-0.3	0.3	-0.3	-0.6	0.6	0.7	-0.4
Diabetes (mother)	0.9	1.1	2.4	0.2	1.1	1.3	1.6	0.7	0.5	-1.2	-1.1	-1.0	-1.1	-0.7	-1.3
Severe depression (siblings)	1.1	1.2	3.1	-1.2	-1.8	-0.8	-0.8	-1.2	1.6	0.8	0.7	0.8	1.0	1.0	0.7
Pack years adult smoking proportion	0.9	1.4	3.1	1.4	1.7	0.1	1.2	1.5	-1.2	-1.1	-0.4	-0.7	-1.5	-1.5	-0.9
Impedance of leg (right)	0.2	1.1	7.8	2.8	-0.2	-1.4	-0.2	1.1	-0.6	-0.5	0.3	-0.1	-0.8	-0.9	0.6
Leg fat-free mass (left)	0.6	3.2	10.9	-0.6	1.5	3.3	2.4	0.9	-0.3	-1.8	-2.0	-1.2	-1.4	-1.3	-2.4
Trunk fat percentage	0.8	3.1	7.8	2.0	2.0	2.8	1.8	1.5	-0.6	-1.8	-1.6	-0.1	-1.8	-2.0	-1.7
Hand grip strength (right)	0.6	1.7	4.5	-0.1	1.0	1.6	1.7	1.1	-1.5	-1.0	-1.2	-2.1	-0.9	-0.6	-1.6
Townsend deprivation index at recruitment	1.0	1.5	3.2	1.8	0.5	-0.5	1.0	1.0	1.4	-1.6	-1.2	0.1	-1.4	-1.5	-1.4
Current tobacco smoking	2.0	3.3	6.4	2.0	2.2	0.5	2.0	2.0	-0.8	-2.0	-1.5	-2.5	-2.2	-1.7	-1.4
Average weekly fortified wine intake	0.8	0.9	3.0	-1.7	-1.4	-0.9	-0.5	-1.1	0.8	0.8	0.3	-0.1	1.0	1.2	0.3
Maternal smoking around birth	0.4	0.6	3.3	0.7	0.2	1.8	0.6	-0.4	1.6	-0.2	-0.2	0.3	-0.1	0.1	-0.2
Fed-up feelings	0.9	1.6	4.6	2.0	0.5	0.8	1.1	1.3	-2.1	-1.0	-1.1	-1.0	-1.0	-1.2	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	4.6	2.2	1.4	0.2	1.6	1.6	-1.7	-1.7	-2.0	-1.9	-1.6	-1.5	-1.8
Relative age voice broke	0.3	0.5	2.9	0.2	0.5	0.4	0.7	0.5	1.7	-0.7	-0.0	0.2	-0.8	-0.5	-0.2
Taking other prescription medications	1.8	2.8	4.5	1.9	1.8	-0.1	1.3	1.8	-0.8	-2.1	-2.0	-1.1	-1.9	-2.1	-1.9
Age when periods started (menarche)	0.1	0.2	1.5	0.2	-0.1	-1.2	-0.2	-0.1	-0.1	0.2	-0.1	-0.1	0.1	0.2	-0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.2	0.3	1.5	0.2	0.7	0.4	-0.1	-0.7	-0.7	-1.4	-0.7	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.7	1.5	0.4	1.6	0.1	0.2	0.5	-0.4	0.3	0.4	-0.3	-0.4	0.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	4.2	-0.9	-0.8	-2.0	-0.6	-0.7	1.0	0.4	0.1	0.4	0.4	0.6	-0.0
Qualifications: CSEs or equivalent	0.2	0.2	1.5	-0.0	-0.3	-1.2	0.3	0.3	-0.1	-0.1	0.2	-0.7	-0.2	-0.1	-0.4
Serious illness, injury or assault to yourself	0.9	1.1	3.0	0.5	1.0	-0.3	1.0	0.9	-1.7	-0.9	-1.0	-1.4	-0.8	-0.7	-1.5
High blood pressure	0.5	1.5	7.7	2.8	1.1	-0.0	0.0	1.0	1.2	-0.8	0.4	1.5	-1.1	-1.5	0.7
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.3	-1.5	-0.8	-1.4	-1.4	-1.4	0.8	1.1	0.5	1.1	1.3	1.2	1.1
Multivitamins +/- minerals	0.9	1.2	4.4	-2.1	-1.1	-1.4	-1.1	-1.2	0.2	0.9	0.4	0.5	1.3	1.0	0.3
Stomach or abdominal pain in last month	0.8	1.0	4.4	0.4	-0.8	-2.1	-1.5	-1.1	1.0	0.6	0.3	0.4	0.9	0.9	0.9
Supplements: Glucosamine	0.1	0.2	0.7	0.1	0.3	0.6	0.1	-0.0	-0.3	-0.4	-0.8	-0.5	-0.2	-0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	-0.6	0.2	0.9	0.7	0.2	-0.4	-0.4	-0.5	-0.7	-0.3	-0.1	-0.7
Medication: Atenolol	1.0	1.3	4.0	0.3	-1.1	-0.0	-1.5	-0.6	1.0	1.0	1.4	2.0	0.9	0.5	1.6
Medication: Levothyroxine sodium	0.2	0.3	0.7	0.7	0.2	-0.7	0.1	0.7	-0.4	-0.3	0.3	0.3	-0.6	-0.8	-0.2
Sitting height	0.3	1.8	3.6	0.8	0.5	1.9	1.4	1.2	-0.4	-1.9	-1.7	-1.1	-1.4	-1.6	-1.2
Chronic bronchitis/emphysema (father)	0.8	1.0	1.8	1.4	0.8	1.3	0.7	1.0	-1.3	-0.9	-0.9	-0.8	-0.8	-1.0	-0.7
High blood pressure (mother)	0.6	0.8	5.4	2.3	-0.1	-0.1	0.1	0.8	0.5	-0.4	0.5	1.1	-0.6	-1.1	0.5
Body mass index (BMI)	0.4	1.6	7.1	-0.5	1.1	2.7	1.4	0.0	-0.1	-0.9	-1.6	-0.3	-0.5	-0.6	-2.0
Impedance of leg (left)	0.3	1.2	8.1	2.8	-0.1	-1.8	-0.5	0.9	-0.2	-0.3	0.4	0.1	-0.7	-0.8	0.9
Leg predicted mass (left)	0.6	3.1	10.7	-0.7	1.5	3.3	2.4	0.8	-0.2	-1.8	-2.0	-1.1	-1.4	-1.2	-2.4
Trunk fat mass	0.8	3.4	9.9	1.3	1.9	3.1	2.1	1.3	-0.4	-1.9	-1.9	-0.4	-1.8	-1.9	-2.1
Waist circumference	0.2	0.7	2.4	-0.8	0.7	1.4	0.8	-0.0	-0.3	-0.7	-1.2	-0.1	-0.4	-0.4	-1.6
Number of incorrect matches in round	0.5	0.8	2.4	-1.5	-1.1	-0.7	-0.5	-1.2	0.9	0.4	-0.6	0.5	0.9	0.8	-0.6
Past tobacco smoking	4.3	7.9	10.6	-3.0	-2.8	-2.9	-3.3	-2.7	1.6	3.2	2.6	2.0	3.0	3.1	2.9
Alcohol usually taken with meals	3.4	5.5	7.2	-2.7	-2.4	-2.1	-2.3	-2.4	1.6	2.7	2.2	2.0	2.6	2.6	2.2
Nervous feelings	1.1	2.1	4.4	1.4	-1.2	-2.1	-1.6	-0.6	0.3	1.6	1.9	1.3	1.0	1.0	2.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	2.1	1.1	-0.5	-1.4	-0.1	0.0	-0.4	-0.2	-0.5	-0.4	-0.1	-0.2	-0.3
Hearing difficulty/problems with background noise	0.3	0.5	1.8	-0.7	0.2	-0.7	-1.0	-0.7	-1.3	0.3	-0.7	-0.4	0.7	0.5	-0.3
Hair/balding pattern: Pattern 2	2.8	3.6	7.7	2.2	1.3	2.8	2.0	2.2	-1.3	-2.1	-1.4	-0.7	-2.1	-2.4	-1.2
Had menopause	0.2	0.3	1.0	-0.2	0.1	0.9	0.5	0.5	-1.0	-0.2	-0.4	0.1	-0.3	-0.7	-0.6
Had other major operations	0.4	0.5	1.2	1.1	0.4	1.1	0.9	0.3	0.5	-0.8	-0.5	-0.0	-0.6	-0.6	-0.6
Forced vital capacity (FVC)	1.3	4.9	7.5	1.6	1.5	2.2	2.7	2.3	-1.2	-2.6	-2.5	-2.1	-2.5	-2.4	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	5.4	2.3	1.1	1.6	0.8	1.1	0.6	-1.1	0.1	0.1	-1.2	-1.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.7	1.7	0.9	0.8	0.8	1.5	-1.0	-1.1	-0.5	-0.5	-1.1	-1.3	-0.2
Qualifications: None of the above	0.2	0.5	1.7	0.6	0.2	0.6	0.5	0.4	-0.8	-0.7	-1.3	-0.4	-0.5	-0.6	-1.2
Financial difficulties in last 2 years	0.7	1.0	4.6	-0.7	0.1	0.4	0.9	-0.1	-0.6	-0.9	-2.1	-0.9	-0.4	-0.4	-1.9
Mouth/teeth dental problems	1.2	1.9	3.9	1.1	2.0	1.4	1.6	1.4	-0.7	-1.4	-0.7	-1.7	-1.6	-1.2	-0.9
Heart attack	0.2	0.3	1.7	-0.8	-0.2	-1.3	-0.6	-0.4	0.5	0.4	-0.0	0.4	0.4	0.4	0.0
Allergy	1.0	2.4	3.5	1.9	1.4	1.3	1.8	1.8	-1.2	-1.5	-0.9	-1.7	-1.7	-1.6	-1.4
Pain all over the body in last month	0.8	0.9	2.3	1.4	1.5	0.3	0.9	0.7	-0.5	-1.0	-0.8	-0.8	-1.0	-0.8	-0.7
Diabetes (self-reported)	0.1	0.1	0.9	-0.9	-0.1	-0.1	-0.1	-0.1	-0.4	0.1	-0.0	-0.1	0.2	0.0	-0.2
Hayfever/allergic rhinitis (self-reported)	2.0	2.7	4.4	-1.3	-1.3	-1.1	-1.9	-1.5	1.2	1.8	1.9	2.1	1.7	1.4	2.0
Medication: Ramipril	3.3	4.2	5.7	-0.9	-1.6	-2.1	-2.3	-2.1	1.5	2.4	2.2	2.3	2.3	2.0	2.2
Medication: Simvastatin	0.4	0.5	1.8	1.3	1.1	0.0	0.6	0.9	0.1	-0.7	-0.3	-0.1	-0.9	-0.9	-0.2
Fluid intelligence score	0.2	0.4	0.7	0.8	0.8	0.7	0.3	0.8	0.4	-0.0	0.7	0.7	-0.5	-0.6	0.8
Illnesses of siblings	0.3	0.5	3.6	-1.9	-0.3	0.1	0.0	-0.5	0.7	0.5	0.3	-0.4	0.3	0.9	-0.0
Neuroticism score	0.6	1.3	5.7	2.4	-1.2	-0.9	-0.8	-0.1	0.5	0.7	1.2	1.6	0.4	0.0	1.4
Weight	0.5	2.6	9.9	-0.1	1.4	3.1	2.0	0.7	-0.1	-1.7	-2.0	-0.7	-1.3	-1.3	-2.2
Impedance of arm (right)	1.1	5.0	25.3	5.0	2.1	0.6	0.9	3.1	-1.0	-1.7	0.4	0.1	-2.6	-2.9	0.4
Arm fat percentage (right)	0.9	3.5	10.2	1.7	2.2	3.2	2.0	1.5	-0.9	-1.7	-1.7	-0.2	-1.8	-1.9	-2.1
Trunk fat-free mass	0.2	1.1	4.4	-2.1	-0.0	1.5	1.0	-0.5	0.3	-0.6	-1.3	-0.7	0.1	0.2	-1.4
Hip circumference	0.4	1.8	8.0	-0.0	1.4	2.8	1.5	0.6	0.0	-1.3	-1.4	-0.2	-1.1	-1.2	-1.7
Time employed in main current job	1.4	1.7	3.1	1.8	1.5	0.8	1.2	1.1	0.0	-1.5	-1.6	-1.4	-1.4	-1.1	-1.3
Alcohol intake versus 10 years previously	2.0	3.1	5.0	1.8	1.5	1.1	1.7	1.7	-0.8	-2.2	-2.1	-0.8	-2.0	-2.2	-2.1
Father’s age at death	0.2	0.3	1.2	-0.8	-0.9	1.1	0.0	-0.4	-0.3	0.3	-0.1	-0.3	0.5	0.6	0.1
Worrier / anxious feelings	2.5	4.8	9.9	1.1	-2.5	-2.0	-2.4	-1.2	1.5	2.1	3.0	2.9	1.6	1.3	3.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.7	0.5	-0.4	0.4	0.4	-0.4	-0.7	-0.8	-0.2	-0.4	-0.7	-0.8
Falls in the last year	4.4	6.0	8.5	2.5	2.5	0.4	2.2	2.6	-1.7	-2.9	-2.8	-2.3	-2.8	-2.8	-2.7
Hair/balding pattern: Pattern 3	3.1	4.6	6.9	-2.3	-2.0	-2.0	-1.8	-2.3	1.6	2.5	2.4	1.5	2.4	2.6	1.7
Number of live births	0.1	0.1	0.4	-0.3	0.1	0.0	-0.4	0.1	-0.6	0.2	-0.1	0.3	0.1	-0.1	0.1
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	7.0	1.5	1.2	2.4	2.6	2.1	-0.9	-2.4	-2.1	-1.9	-2.3	-2.1	-2.1
Pulse rate	0.6	1.0	4.3	-2.1	-0.7	-1.6	-0.6	-1.1	0.2	0.7	-0.4	-0.4	0.9	1.0	-0.6
Happiness	1.8	2.1	6.5	-1.5	-1.0	-2.5	-1.8	-1.3	1.4	1.2	0.8	1.5	1.4	1.1	1.1
Noisy workplace	0.7	0.9	2.1	1.0	0.3	1.4	1.0	0.2	-0.7	-0.9	-1.4	-1.0	-0.5	-0.6	-1.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	-0.2	-0.1	-1.0	-0.5	-0.5	0.1	0.7	0.7	0.4	0.5	0.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.9	0.2	-0.3	-0.9	-0.8	-0.1	0.3	0.2	0.2	0.3	0.2	0.1	0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	2.6	-0.4	-0.9	0.2	-0.8	-0.5	0.5	0.8	0.7	1.6	0.7	0.3	0.4
Asthma	2.9	5.7	8.2	-2.2	-2.3	-1.7	-2.7	-2.9	2.5	2.4	1.7	2.6	2.7	2.5	2.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.4	1.8	-0.6	-0.1	-0.9	-0.1	-1.0	0.8	0.7	1.3	0.6	0.1	0.7
Medication: Cholesterol lowering	0.4	0.6	2.8	-0.4	-0.7	-1.7	-1.0	-0.7	1.0	0.6	0.2	0.4	0.6	0.7	0.6
Depression (self-reported)	0.8	0.9	1.9	1.2	-0.8	-1.4	-1.0	-0.5	1.1	0.6	1.0	1.3	0.5	0.2	1.0
Medication: Lansoprazole	1.8	2.1	3.5	1.9	1.4	-0.9	1.2	1.5	-1.3	-1.5	-1.6	-1.1	-1.6	-1.5	-1.5
Prospective memory result	0.1	0.2	0.6	0.8	-0.5	0.1	-0.0	0.4	0.4	-0.3	-0.1	0.5	-0.4	-0.5	0.2
Lung cancer (father)	1.8	2.1	4.3	-0.8	-1.4	-0.7	-1.7	-1.0	1.1	1.6	2.1	2.0	1.3	1.0	1.8
Illnesses of mother	0.5	0.6	2.7	-1.6	-0.3	-1.3	-0.5	-0.5	0.1	0.6	0.6	-0.8	0.6	1.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	4.7	0.7	0.5	2.2	2.2	1.2	-0.3	-1.9	-1.9	-1.9	-1.6	-1.2	-1.7
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	1.2	0.6	-1.0	0.3	1.0	-0.2	-0.9	-0.4	-0.2	-1.0	-1.0	-0.3
Impedance of arm (left)	1.1	5.2	25.3	5.0	2.0	1.4	1.1	3.1	-1.2	-1.7	0.4	0.0	-2.6	-2.8	0.6
Arm fat mass (right)	0.8	3.2	9.9	0.8	1.9	3.1	2.1	1.1	-0.6	-1.8	-1.9	-0.5	-1.6	-1.7	-2.4
Trunk predicted mass	0.2	1.1	4.6	-2.1	-0.0	1.5	1.0	-0.5	0.3	-0.6	-1.2	-0.6	0.1	0.2	-1.4
Standing height	0.2	1.6	3.3	0.9	0.8	1.7	1.5	1.5	0.0	-1.8	-0.9	-0.7	-1.7	-1.7	-0.8
Length of working week for main job	1.4	1.6	3.9	0.7	0.7	-0.2	1.5	1.2	-0.5	-1.5	-1.7	-1.1	-1.3	-1.4	-2.0
Exposure to tobacco smoke at home	0.3	0.3	2.0	-0.6	0.2	-1.4	-0.3	-0.4	-0.1	0.0	-0.7	0.1	0.2	0.0	-0.5
Breastfed as a baby	0.9	1.2	5.1	1.9	1.1	0.3	0.4	0.7	2.3	-0.7	0.5	0.4	-1.2	-0.7	0.8
Tense / ‘highly strung’	0.3	0.5	3.5	1.9	0.3	-1.1	-0.1	0.4	0.1	-0.1	-0.0	0.5	-0.4	-0.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.6	2.1	0.1	-0.3	-0.3	0.4	0.4	-0.3	0.3	1.6	-0.4	-1.0	0.3
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	-0.1	-0.0	0.3	-0.1	0.1	-0.3	0.1	0.2	0.1	0.1	0.0	-0.0
Birth weight of first child	0.5	0.9	2.2	-0.5	-0.6	-0.1	-0.9	-1.0	1.5	0.8	1.0	1.2	0.9	0.8	1.0
Peak expiratory flow (PEF)	0.3	0.6	1.7	-0.0	0.5	1.3	1.0	0.5	-0.1	-1.0	-1.0	-0.4	-0.7	-0.8	-1.1
Pulse wave reflection index	0.2	0.3	2.2	1.5	0.1	0.4	-0.1	0.4	-0.4	-0.4	-0.1	-0.1	-0.3	-0.5	0.4
Ever highly irritable/argumentative for 2 days	1.6	2.0	6.5	1.5	1.0	2.5	1.7	1.4	-0.0	-1.4	-0.8	0.0	-1.5	-1.7	-1.0
Loud music exposure frequency	2.6	2.8	4.3	1.9	1.7	0.8	1.8	1.6	-1.3	-1.8	-1.9	-1.6	-1.7	-1.7	-2.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.2	-0.3	0.2	-0.1	-0.4	-0.3	0.1	0.7	1.1	0.5	0.5	0.6	0.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.4	-1.0	-1.1	-1.2	-0.8	-1.0	0.3	0.8	0.3	0.1	1.0	1.0	0.4
Blood clot in the leg (DVT)	0.3	0.4	1.5	-1.2	-0.5	-0.2	-0.3	-0.5	-0.7	0.4	0.0	-0.8	0.6	0.7	0.0
Medication: Paracetamol	1.2	2.0	5.2	0.7	-1.2	-1.1	-1.8	-1.0	1.7	1.3	1.6	2.3	1.0	0.6	1.6
Headache pain in last month	2.0	3.4	5.6	-0.5	-2.0	-1.9	-2.1	-1.7	2.1	1.8	1.9	2.4	1.7	1.4	1.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	2.4	-0.7	-0.2	1.6	0.7	0.2	-0.7	-0.0	0.3	-0.4	-0.0	0.0	-0.2
Glaucoma (self-reported)	1.6	1.8	3.6	0.1	1.9	-0.7	1.3	1.5	-1.5	-1.2	-1.3	-1.7	-1.3	-1.1	-1.7
Gout (self-reported)	0.3	0.4	1.2	0.2	0.4	0.2	0.6	0.4	0.0	-0.9	-1.1	-0.8	-0.5	-0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.9	1.0	1.3	0.4	1.3	1.4	-1.2	-1.5	-1.4	-1.3	-1.5	-1.5	-1.7
Medication: Amlodipine	0.5	0.7	3.2	1.8	0.5	-0.6	-0.4	0.8	0.1	0.0	0.8	1.3	-0.5	-0.8	1.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.8	-0.5	0.3	-0.1	0.1	-0.1	0.2	-0.6	-1.4	-0.3	-0.2	-0.2	-1.0
Birth weight	0.9	1.9	3.8	2.0	1.5	1.1	1.4	1.8	-0.5	-1.5	-0.5	-1.0	-1.8	-1.7	-0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.2	1.5	0.2	0.4	0.3	0.6	-1.4	-0.6	-1.1	0.1	-0.7	-1.0	-1.1
High blood pressure (siblings)	0.5	0.8	3.8	1.9	0.5	0.4	0.6	1.0	-0.5	-0.8	-0.2	0.0	-0.9	-1.3	-0.3
Forced vital capacity (FVC), Best measure	0.6	2.4	4.0	0.7	0.7	1.8	2.0	1.4	-0.2	-2.0	-1.9	-1.7	-1.8	-1.5	-1.6
Body fat percentage	0.7	2.7	8.1	1.8	1.8	2.9	1.7	1.2	-0.5	-1.6	-1.5	-0.0	-1.6	-1.7	-1.8
Leg fat percentage (right)	0.5	1.9	5.2	0.9	1.3	2.3	1.6	0.7	-1.0	-1.3	-1.8	-0.7	-1.1	-1.1	-1.9
Arm fat-free mass (right)	0.3	1.4	5.5	-2.4	-0.1	1.9	1.1	-0.8	0.5	-0.5	-1.5	-0.7	0.2	0.4	-1.5
Exposure to tobacco smoke outside home	4.8	6.4	9.2	3.0	2.8	3.0	2.9	2.7	-0.4	-2.8	-2.0	-1.3	-2.9	-3.0	-2.0
Comparative body size at age 10	0.6	1.6	4.0	-2.0	-0.5	0.9	-0.8	-1.1	1.6	1.2	1.5	1.6	1.1	1.0	1.0
Number of full brothers	0.9	1.2	1.9	1.0	1.0	1.0	1.0	1.1	-0.4	-1.3	-1.1	-1.4	-1.3	-1.1	-1.0
Worry too long after embarrassment	1.2	2.1	3.8	0.5	-1.6	-1.8	-1.4	-0.8	1.1	1.5	1.8	1.9	1.0	0.8	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	4.2	2.0	0.2	-0.6	-0.4	0.3	-0.1	-0.2	0.1	0.9	-0.2	-0.6	0.1
Wheeze or whistling in the chest in last year	0.5	0.8	2.6	0.6	0.8	-1.3	0.2	0.1	0.9	-1.1	-1.6	-0.6	-0.7	-0.8	-0.9
Number of children fathered	0.5	0.5	4.6	0.4	-0.2	2.1	0.2	0.2	-0.6	0.1	0.4	0.8	-0.0	-0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	3.7	4.3	6.5	2.0	2.0	1.4	2.2	2.2	-1.1	-2.5	-2.4	-2.1	-2.3	-2.2	-2.0
Age at first live birth	0.1	0.2	0.9	-1.0	-0.4	0.8	0.5	0.1	-0.0	0.3	0.7	-0.3	0.0	0.2	0.2
Pulse wave peak to peak time	0.4	0.5	1.3	-1.0	-0.4	1.1	-0.1	-0.8	0.2	0.8	0.5	0.2	0.8	0.8	0.3
Health satisfaction	0.9	1.2	3.6	1.9	0.8	1.2	0.9	0.9	-0.1	-1.4	-1.1	-0.2	-1.1	-1.4	-0.8
Shortness of breath walking on level ground	1.1	1.3	3.2	0.7	0.8	0.4	0.9	0.9	-1.8	-1.2	-1.6	-1.0	-0.9	-1.3	-1.5
Qualifications: College or University degree	0.1	0.4	1.3	0.9	1.0	-0.4	-0.1	0.4	0.7	-0.2	0.3	1.1	-0.3	-0.7	0.6
Eye problems/disorders: None of the above	0.2	0.3	1.4	0.3	-0.4	0.7	-0.0	-0.5	1.2	0.1	0.4	-0.0	0.3	0.4	0.7
Mouth/teeth dental problems: Loose teeth	8.1	9.7	12.7	3.4	3.0	2.5	3.1	3.2	-2.6	-3.4	-3.3	-2.3	-3.3	-3.6	-3.3
Emphysema/chronic bronchitis	0.6	0.7	2.3	1.3	1.5	-0.2	0.6	0.8	0.2	-0.8	-0.7	-0.1	-0.8	-1.0	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	2.6	-1.3	0.6	1.6	1.2	0.5	-1.1	-0.5	-0.5	-1.5	-0.4	-0.1	-0.8
Neck or shoulder pain in last month	0.3	0.4	1.6	-0.4	-1.3	-0.2	-0.8	-0.5	-0.7	0.5	0.3	0.9	0.7	0.2	0.2
Medication: Blood pressure	0.6	1.1	3.4	1.0	-0.1	-1.8	-1.4	-0.4	1.2	0.6	0.5	1.9	0.5	-0.0	1.0
Angina (self-reported)	0.1	0.1	0.4	0.3	0.0	-0.4	-0.7	-0.6	0.3	0.3	-0.3	0.4	0.5	0.3	-0.2
Migraine (self-reported)	1.2	1.5	4.4	-0.4	-1.1	-2.1	-1.7	-1.4	0.5	1.2	0.5	0.9	1.5	1.1	1.1
Medication: Ibuprofen	0.7	0.9	2.1	1.4	-0.8	-0.2	-1.1	-0.3	-1.1	1.0	0.9	1.4	0.9	0.3	0.9
Medication: Allopurinol	0.3	0.4	1.1	-0.0	0.3	-0.1	0.5	0.4	-0.4	-0.7	-1.0	-0.7	-0.5	-0.5	-1.0
Medication: Omeprazole	1.4	1.7	4.4	2.1	2.0	-0.0	0.5	1.1	0.7	-1.5	-1.1	0.5	-1.5	-1.7	-0.7
Medication: Seretide 50 evohaler	0.5	0.6	1.1	0.6	1.0	0.4	0.7	0.5	0.1	-1.1	-1.0	-0.8	-0.8	-0.7	-0.9
Mean time to correctly identify matches	3.6	6.8	12.6	3.6	3.3	3.3	2.6	2.9	-1.5	-2.5	-1.7	-0.9	-2.9	-3.1	-1.3
Heart disease (mother)	0.4	0.5	1.5	-0.4	0.5	0.8	0.5	0.2	-1.2	-0.6	-1.1	-1.0	-0.3	-0.3	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.8	1.1	0.8	0.5	0.8	1.0	-1.3	-1.1	-1.3	-0.8	-0.7	-1.1	-1.2
Whole body fat mass	0.6	2.6	8.1	0.8	1.6	2.9	1.9	0.9	-0.2	-1.7	-1.8	-0.3	-1.4	-1.5	-2.1
Leg fat mass (right)	0.7	2.8	7.7	0.5	1.5	2.8	2.1	0.8	-0.6	-1.7	-2.2	-0.8	-1.4	-1.4	-2.4
Arm predicted mass (right)	0.3	1.4	4.5	-2.1	0.1	2.1	1.3	-0.5	0.3	-0.8	-1.5	-0.8	-0.1	0.1	-1.6
Pulse rate, automated reading	1.4	4.5	8.4	-2.5	-2.3	-2.9	-2.3	-2.4	1.5	2.1	1.1	1.7	2.4	2.2	1.2
Alcohol intake frequency.	0.9	2.2	3.7	1.9	1.7	0.3	1.1	1.4	-0.5	-1.7	-1.9	-1.4	-1.7	-1.6	-1.6
Comparative height size at age 10	0.2	1.3	4.4	-0.5	0.6	2.1	1.3	1.0	-0.6	-1.4	-1.1	-1.3	-1.1	-1.0	-1.0
Number of full sisters	0.2	0.3	1.4	0.3	-0.1	0.4	0.3	0.3	-1.2	-0.4	-0.5	-0.8	-0.2	-0.3	-0.5
Suffer from ‘nerves’	0.6	1.0	2.7	1.2	-0.7	-1.6	-1.1	-0.3	0.7	0.7	0.9	1.5	0.3	-0.0	1.2
Overall health rating	0.8	1.7	4.9	0.8	0.8	-0.4	1.1	0.8	-0.7	-1.7	-2.2	-1.2	-1.3	-1.4	-2.1
Chest pain or discomfort	0.5	0.7	1.8	0.9	0.8	-0.0	0.7	0.7	0.0	-1.1	-1.2	-1.3	-1.0	-0.7	-0.9
Had major operations	2.8	3.3	6.9	-1.5	-1.1	-2.6	-2.3	-1.8	1.4	1.8	1.7	1.4	1.8	1.8	2.0
Age at last live birth	0.2	0.3	1.4	-0.4	0.2	0.4	1.2	0.9	-0.2	-0.3	0.3	-0.5	-0.6	-0.4	-0.4
Family relationship satisfaction	0.8	0.9	2.0	0.9	0.7	-0.3	0.8	0.9	-1.1	-1.2	-1.4	-1.1	-0.7	-0.9	-1.2
Leg pain on walking	2.4	3.1	7.6	2.8	2.1	1.6	1.4	1.5	-1.0	-2.0	-1.8	-0.8	-1.7	-1.9	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.1	-0.3	-0.7	-1.1	-0.0	0.0	-0.6	-0.1	-0.4	-0.5	0.1	0.1	-0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.8	-0.0	-0.9	0.1	-0.2	-0.4	-1.3	0.4	-0.0	-0.3	0.7	0.6	-0.0
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	5.8	2.4	1.8	2.1	1.0	1.8	-1.2	-0.8	0.4	-0.4	-1.3	-1.5	0.1
Medication: Aspirin	1.1	1.4	4.1	-1.1	-0.8	-2.0	-1.6	-1.4	0.9	1.1	0.3	0.6	1.3	1.2	0.9
Supplements: Vitamin C	1.8	2.2	3.3	-1.2	-1.4	-1.1	-1.8	-1.7	1.3	1.4	1.3	1.8	1.5	1.4	1.6
Knee pain experienced in last month	0.3	0.4	1.0	1.0	0.6	0.3	0.4	0.5	0.0	-0.8	-0.7	-0.0	-0.8	-1.0	-0.7
Hypertension (Self-reported)	0.6	1.7	8.0	2.8	1.5	-0.0	0.2	1.1	1.2	-1.1	-0.0	1.2	-1.3	-1.7	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.8	5.6	10.3	3.2	2.7	1.2	2.2	2.9	-1.5	-2.6	-1.8	-1.5	-2.9	-2.9	-1.8
Illnesses of father: Heart disease	1.9	2.6	4.2	2.1	1.8	1.1	1.5	1.6	-0.9	-1.9	-1.8	-1.1	-1.8	-1.9	-1.6
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-0.4	-0.9	-0.2	-0.7	-0.6	-0.8	0.8	0.7	0.3	1.0	0.8	0.6
Smoking status: Previous	1.9	2.8	5.9	1.8	1.5	2.4	1.8	1.5	-1.1	-1.9	-1.6	-0.5	-1.6	-2.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.8	0.5	0.9	1.2	1.1	0.6	-1.1	-1.2	-1.6	-1.7	-0.9	-0.7	-1.1
Whole body fat-free mass	0.3	1.6	5.2	-1.6	0.5	2.3	1.6	-0.0	0.2	-1.1	-1.6	-0.9	-0.5	-0.3	-1.8
Leg fat-free mass (right)	0.5	2.8	9.6	-0.8	1.4	3.1	2.2	0.8	0.0	-1.7	-1.9	-1.1	-1.3	-1.1	-2.2
Arm fat percentage (left)	1.0	3.9	14.0	1.8	2.1	3.7	2.1	1.6	-0.9	-1.8	-1.6	-0.1	-1.8	-2.0	-2.0
Average weekly red wine intake	0.1	0.1	1.1	0.3	-0.3	1.0	0.1	0.2	-0.3	-0.0	0.3	0.2	0.1	-0.1	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.2	0.0	0.6	0.4	0.9	0.5	-0.3	-0.8	-0.8	-0.0	-0.6	-0.8	-1.1
Mood swings	0.4	0.8	6.3	2.5	0.4	0.3	0.3	0.7	-1.0	-0.5	-0.3	0.1	-0.5	-0.9	-0.2
Loneliness, isolation	0.9	1.2	3.9	-1.2	-2.0	-1.6	-0.8	-1.3	0.7	0.9	0.4	0.5	1.2	1.2	0.3
Long-standing illness, disability or infirmity	1.2	1.9	4.0	1.3	1.5	-0.4	1.0	1.2	-0.3	-1.9	-2.0	-1.2	-1.6	-1.5	-1.4
Ever had bowel cancer screening	3.1	3.6	6.2	2.3	2.2	0.6	1.5	2.1	-1.9	-2.0	-1.8	-0.6	-2.1	-2.5	-2.0
Diabetes diagnosed by doctor	0.6	1.0	3.9	-2.0	-0.9	-1.4	-1.0	-1.0	-0.2	1.0	0.5	0.2	1.1	1.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.9	-1.4	-1.1	-0.6	-1.0	-0.8	-0.7	0.9	0.3	0.3	1.0	0.9	0.4
Friendships satisfaction	0.6	0.7	1.6	1.2	0.9	-0.5	0.5	1.3	-0.9	-0.8	-0.6	-0.4	-0.9	-1.1	-0.7
Qualifications: nursing, teaching	0.5	0.7	2.0	-1.1	-0.6	-0.9	-0.5	-0.6	1.4	0.5	1.0	0.3	0.5	0.8	1.1
Commuting to job workplace: Walk	0.3	0.3	0.8	-0.3	0.9	-0.1	0.5	0.8	-0.3	-0.5	-0.2	-0.5	-0.7	-0.7	-0.4
Eye problems/disorders: Cataract	0.1	0.2	0.4	0.7	-0.0	0.6	-0.1	0.5	-0.5	0.1	0.4	0.4	-0.3	-0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.7	-1.4	-1.9	-0.7	-1.4	-1.8	0.8	1.5	0.7	0.8	1.7	1.7	1.1
Medication for cholesterol	0.2	0.3	1.4	-0.6	-0.3	-1.2	-0.4	-0.2	-0.9	0.5	-0.3	-0.4	0.4	0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.2	0.6	1.2	-0.2	0.9	0.6	0.2	-1.3	-1.5	-1.1	-1.1	-1.0	-1.1
Back pain experienced in last month	0.2	0.3	0.9	-0.1	-0.4	-0.9	-0.5	-0.2	0.8	0.3	0.5	0.6	0.1	0.2	0.7
Mineral and other dietary supplements	0.2	0.3	0.7	0.5	0.7	-0.4	0.8	0.7	0.5	-0.4	-0.2	-0.3	-0.8	-0.5	-0.4
Breast cancer (self-reported)	0.3	0.3	2.3	0.4	0.4	1.5	0.5	0.3	0.3	-0.5	-0.1	-0.3	-0.4	-0.3	-0.1
Asthma (self-reported)	2.5	4.9	7.1	-2.0	-2.1	-1.6	-2.5	-2.7	2.5	2.2	1.6	2.5	2.5	2.3	2.1
Osteoporosis (self-reported)	1.3	1.7	4.5	-2.1	-1.2	-1.5	-1.3	-1.5	-0.3	1.3	0.5	0.1	1.6	1.7	0.4
Osteoarthritis (self-reported)	2.2	2.8	7.7	2.8	1.3	2.3	1.4	1.6	-0.2	-1.8	-1.3	0.3	-1.8	-2.3	-1.2
Medication: Aspirin	1.0	1.3	4.2	-0.9	-0.7	-2.0	-1.6	-1.3	0.9	1.1	0.4	0.7	1.3	1.1	0.9
Medication: Gliclazide	0.4	0.4	1.9	-0.6	0.1	-0.8	0.3	0.4	-1.4	-0.2	-0.5	-0.9	-0.2	-0.3	-0.9
Illnesses of father: None of the above (group 1)	2.1	2.6	4.5	-1.2	-1.5	-1.5	-1.4	-1.4	1.7	1.8	2.1	2.1	1.4	1.4	1.6
Smoking status: Current	2.0	3.2	7.1	1.7	2.3	0.2	2.0	1.8	-0.7	-2.0	-1.6	-2.7	-2.1	-1.6	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.3	0.3	0.1	0.4	1.4	0.9	-1.3	-1.4	-2.1	-1.7	-1.2	-1.0	-1.8
Whole body water mass	0.3	1.7	5.3	-1.6	0.6	2.3	1.7	-0.0	0.2	-1.1	-1.7	-0.9	-0.5	-0.4	-1.9
Leg predicted mass (right)	0.5	2.8	9.9	-0.8	1.4	3.1	2.3	0.8	0.0	-1.7	-1.8	-1.1	-1.3	-1.1	-2.2
Arm fat mass (left)	0.8	3.2	11.2	0.8	1.8	3.4	2.1	1.1	-0.5	-1.8	-1.9	-0.5	-1.5	-1.6	-2.3
Number of self-reported non-cancer illnesses	0.3	0.6	2.0	0.9	0.2	-1.3	-0.7	-0.1	1.4	-0.0	0.4	1.1	-0.1	-0.3	0.9
Average weekly champagne plus white wine intake	1.7	2.3	4.4	-2.1	-1.2	-0.5	-1.3	-1.8	1.2	1.8	1.4	1.5	1.8	1.7	1.5
Miserableness	0.2	0.3	1.8	1.4	-0.2	-0.4	-0.0	0.1	1.0	-0.2	0.1	0.8	-0.2	-0.5	0.1
Guilty feelings	2.1	3.1	5.7	-0.4	-2.4	-0.7	-1.6	-1.7	2.3	1.8	1.8	2.0	1.7	1.6	2.0
Wears glasses or contact lenses	0.4	0.5	1.5	0.5	1.2	-0.4	0.6	0.6	-0.1	-0.7	-0.9	-0.7	-0.7	-0.6	-0.9
Ever taken oral contraceptive pill	0.4	0.5	1.8	1.3	0.4	1.4	-0.2	0.0	0.5	0.2	0.8	0.9	0.1	-0.1	0.7
Hearing aid user	0.2	0.2	0.8	-0.5	-0.4	0.1	-0.4	-0.7	0.9	0.3	-0.2	0.7	0.5	0.4	0.2
Mother’s age at death	0.1	0.2	1.0	0.3	-0.0	-0.1	0.0	0.6	-1.0	-0.1	-0.3	-0.1	-0.2	-0.5	-0.1
Financial situation satisfaction	1.4	1.8	3.6	0.6	1.3	0.6	1.3	1.1	-1.8	-1.4	-1.9	-1.2	-1.0	-1.3	-1.8
Tinnitus: Yes, now most or all of the time	1.7	1.9	3.7	1.8	1.1	1.5	1.2	1.4	-1.1	-1.5	-1.4	-0.2	-1.4	-1.9	-1.4
Commuting to job workplace: Public transport	1.3	1.6	3.8	0.5	-0.3	-1.2	-1.3	-0.4	2.0	0.9	1.8	1.9	0.4	0.3	1.9
Eye problems/disorders: Glaucoma	0.6	0.7	1.8	-0.1	1.2	-0.7	0.7	1.0	-1.3	-0.6	-0.7	-0.7	-0.7	-0.7	-1.1
Medication: Blood pressure	1.0	1.9	6.2	2.5	1.4	1.7	1.0	1.3	1.0	-1.4	-0.2	0.4	-1.6	-1.7	0.1
Pain type(s) experienced in last month: Hip pain	5.8	7.3	11.2	3.3	3.3	1.9	2.7	2.5	-0.7	-3.1	-3.0	-1.8	-3.2	-3.1	-2.5
Supplements: Fish oil (including cod liver oil)	1.4	1.9	3.6	-0.6	-1.9	-0.0	-1.8	-1.3	0.3	1.3	1.5	1.7	1.6	1.1	1.7
High cholesterol (Self-reported)	0.8	1.4	2.5	1.0	1.5	0.7	1.2	1.2	-0.8	-1.2	-1.2	-1.6	-1.3	-1.0	-1.1
Medication: Bendroflumethiazide	0.7	1.0	3.0	1.7	1.2	0.7	0.6	1.3	0.4	-1.1	-0.4	-0.6	-1.4	-1.3	-0.2
Medication: Paracetamol	1.5	2.3	4.2	0.1	-1.6	-1.3	-2.0	-1.4	1.3	1.7	1.7	2.0	1.5	1.1	1.7
Medication: Lisinopril	0.6	0.8	2.1	1.4	0.8	-0.9	0.4	1.0	0.4	-1.2	-0.6	-0.0	-1.2	-1.3	-0.3
Medication: Atorvastatin	1.9	2.4	4.3	-1.6	-1.5	-2.1	-1.9	-1.8	1.2	1.5	1.0	0.9	1.7	1.7	1.1
Illnesses of father: High blood pressure	0.2	0.3	1.7	0.2	0.3	1.3	0.5	0.3	0.9	-0.4	0.2	0.1	-0.4	-0.4	-0.0
Alcohol drinker status: Never	1.2	1.4	2.9	-1.1	-1.3	-1.7	-1.4	-1.4	1.2	1.1	0.4	0.7	1.3	1.4	0.9
Ever smoked	2.3	4.0	6.4	2.5	2.1	1.9	2.3	2.0	-0.6	-2.2	-1.6	-1.4	-2.3	-2.3	-1.9
Basal metabolic rate	0.4	2.1	6.7	-1.2	0.9	2.6	1.9	0.3	-0.0	-1.4	-1.9	-1.0	-0.8	-0.7	-2.2
Leg fat percentage (left)	0.5	2.0	5.1	1.0	1.5	2.2	1.6	0.7	-0.7	-1.4	-1.9	-0.7	-1.1	-1.1	-1.9
Arm fat-free mass (left)	0.3	1.3	3.9	-1.7	0.3	1.4	1.3	-0.3	0.3	-1.0	-1.8	-0.9	-0.3	-0.1	-2.0
Number of operations (self-reported)	0.5	0.8	3.0	-0.2	-0.2	-1.7	-1.3	-0.9	1.1	0.6	0.4	0.6	0.7	0.8	0.9
Average weekly beer plus cider intake	0.4	0.6	2.5	0.9	0.6	1.6	0.7	0.4	-0.1	-0.8	-0.9	-0.4	-0.7	-0.8	-0.7
Irritability	0.9	1.6	12.6	3.5	0.2	1.2	0.4	1.0	0.1	-0.4	0.5	1.2	-0.7	-1.1	0.5
Risk taking	0.4	0.5	3.6	0.3	0.3	1.9	0.8	0.2	-0.0	-0.7	-0.6	0.2	-0.3	-0.6	-0.8
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	0.5	0.1	-1.1	-1.0	-0.8	0.4	0.6	0.5	0.6	0.7	0.7	0.9
Fractured/broken bones in last 5 years	0.3	0.4	3.8	-0.6	-0.1	-1.9	-0.3	-0.3	0.7	0.3	-0.1	0.1	0.2	0.4	-0.4
Age started oral contraceptive pill	0.3	0.4	1.8	0.5	0.2	1.3	0.0	0.2	0.9	0.2	0.9	1.0	-0.0	-0.1	0.5
Diastolic blood pressure, automated reading	4.9	15.2	24.7	4.9	3.8	2.4	3.8	4.4	-3.0	-4.4	-3.8	-2.1	-4.4	-5.0	-3.6
Ever depressed for a whole week	0.5	0.7	1.7	1.1	0.6	0.8	0.9	1.3	-0.3	-0.9	0.2	0.1	-1.0	-1.2	-0.1
Unable to work because of sickness or disability	4.6	6.0	9.5	1.9	2.3	0.7	2.6	2.2	-1.5	-3.1	-3.0	-2.2	-2.7	-2.7	-3.1
Commuting to job workplace: Cycle	1.6	2.0	4.3	2.0	1.5	1.0	1.4	2.1	-0.2	-1.3	-0.5	-0.2	-1.9	-2.0	-0.7
Myopia	0.4	0.6	1.6	1.2	0.8	-0.1	0.8	1.3	-0.3	-0.8	0.1	-0.8	-1.0	-0.9	-0.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	5.8	-2.4	-1.0	-0.0	-0.0	-0.7	-1.1	0.7	-0.1	-1.2	0.8	1.2	-0.5
Cholesterol lowering medication	0.3	0.4	1.1	1.1	0.9	0.7	0.4	0.7	0.3	-0.4	0.5	0.3	-0.7	-0.7	0.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.5	1.9	1.7	0.1	0.7	1.2	0.1	-1.6	-1.4	0.0	-1.5	-1.7	-1.0
Pain experienced in last month	0.5	0.9	3.6	0.2	0.9	1.9	1.4	0.9	-0.6	-0.6	-0.4	-1.3	-0.7	-0.4	-0.5
Supplements: Calcium	0.7	0.7	1.6	-0.7	0.3	0.6	1.1	0.6	-0.9	-0.9	-1.0	-1.2	-0.7	-0.5	-1.2
Basal cell carcinoma (self-reported)	0.5	0.5	1.2	-0.5	-0.4	-0.4	-0.8	-0.6	0.4	0.9	1.1	0.6	0.8	0.8	1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.4	-0.7	-0.0	-1.5	-0.6	-0.4	0.5	0.4	-0.0	0.4	0.4	0.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.4	-1.2	-0.5	-0.2	-0.3	-0.4	-0.5	0.3	0.1	-0.7	0.5	0.6	0.0
Heart disease (siblings)	0.8	0.9	1.9	1.4	1.3	0.3	1.0	0.8	-0.5	-1.1	-1.0	-0.8	-1.0	-1.0	-1.0
Alcohol drinker status: Previous	1.1	1.3	5.9	2.4	1.4	0.7	0.7	1.1	0.4	-1.1	-0.4	-0.3	-1.3	-1.4	-0.1
Pack years of smoking	0.6	0.8	2.3	1.2	1.5	-0.1	0.7	1.2	-0.8	-0.8	-0.1	-0.3	-1.2	-1.2	-0.5
Impedance of whole body	0.6	2.9	18.6	4.3	1.0	-0.3	0.2	2.2	-0.6	-1.0	0.6	0.3	-1.8	-2.0	0.9
Leg fat mass (left)	0.7	2.9	7.7	0.4	1.6	2.8	2.1	0.8	-0.4	-1.8	-2.2	-0.8	-1.4	-1.4	-2.5
Arm predicted mass (left)	0.3	1.4	4.2	-2.0	0.2	1.3	1.3	-0.5	0.3	-0.9	-1.9	-1.0	-0.2	-0.0	-2.1