Best TWAS P=3.87e-51 · Best GWAS P=7.34e-51 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TBC1D4 | 0.07 | 0.06 | lasso | 3 | 0.06 | 9.0e-08 | 15.00 | -15.0 | 3.9e-51 | -0.99 | 0.00 | 1.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | UCHL3 | 0.27 | 0.14 | lasso | 10 | 0.26 | 1.1e-31 | -0.37 | -6.3 | 3.3e-10 | -0.19 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | RP11-173B14.5 | 0.25 | 0.09 | lasso | 6 | 0.07 | 1.6e-06 | -5.14 | -5.3 | 1.0e-07 | -0.16 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Adipose Visceral Omentum | RP11-173B14.5 | 0.14 | 0.05 | lasso | 5 | 0.07 | 2.2e-04 | -5.14 | -6.5 | 9.9e-11 | -0.19 | 0.30 | 0.03 | TRUE |
| 5 | GTEx | Artery Aorta | RP11-173B14.4 | 0.35 | 0.22 | lasso | 5 | 0.20 | 2.4e-11 | -5.14 | -5.8 | 5.1e-09 | -0.19 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Aorta | RP11-173B14.5 | 0.50 | 0.43 | lasso | 5 | 0.42 | 3.4e-25 | -5.14 | -5.2 | 1.6e-07 | -0.17 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Artery Tibial | UCHL3 | 0.20 | 0.09 | lasso | 3 | 0.17 | 4.1e-13 | 7.79 | -8.5 | 2.5e-17 | -0.49 | 1.00 | 0.00 | TRUE |
| 8 | GTEx | Artery Tibial | TBC1D4 | 0.20 | 0.01 | enet | 27 | 0.04 | 3.6e-04 | -2.19 | -7.8 | 6.1e-15 | -0.58 | 0.06 | 0.86 | FALSE |
| 9 | GTEx | Artery Tibial | RP11-173B14.5 | 0.60 | 0.44 | enet | 29 | 0.47 | 2.0e-40 | -5.14 | -6.3 | 3.8e-10 | -0.27 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Artery Tibial | RP11-29G8.3 | 0.11 | 0.02 | lasso | 4 | 0.04 | 7.3e-04 | 7.79 | -6.3 | 3.7e-10 | -0.39 | 0.29 | 0.04 | FALSE |
| 11 | GTEx | Brain Caudate basal ganglia | UCHL3 | 0.66 | 0.28 | enet | 36 | 0.32 | 8.1e-10 | 8.11 | -7.9 | 2.0e-15 | -0.49 | 0.95 | 0.00 | FALSE |
| 12 | GTEx | Brain Caudate basal ganglia | RP11-173B14.5 | 0.28 | 0.20 | lasso | 8 | 0.16 | 2.8e-05 | 8.11 | -8.6 | 1.0e-17 | -0.56 | 0.30 | 0.05 | FALSE |
| 13 | GTEx | Brain Cortex | UCHL3 | 0.58 | 0.10 | lasso | 15 | 0.09 | 1.6e-03 | 7.75 | -9.2 | 4.8e-20 | -0.49 | 0.28 | 0.06 | FALSE |
| 14 | GTEx | Brain Frontal Cortex BA9 | UCHL3 | 0.21 | 0.07 | lasso | 8 | 0.11 | 9.4e-04 | 7.79 | -8.6 | 9.1e-18 | -0.49 | 0.12 | 0.08 | FALSE |
| 15 | GTEx | Brain Frontal Cortex BA9 | RP11-173B14.5 | 0.23 | 0.12 | lasso | 7 | 0.10 | 1.5e-03 | -5.14 | -7.8 | 7.9e-15 | -0.36 | 0.09 | 0.20 | FALSE |
| 16 | GTEx | Brain Frontal Cortex BA9 | RP11-29G8.3 | 0.27 | 0.06 | lasso | 3 | 0.08 | 4.0e-03 | -1.17 | -6.3 | 2.5e-10 | -0.36 | 0.12 | 0.09 | TRUE |
| 17 | GTEx | Brain Hippocampus | UCHL3 | 0.44 | 0.24 | lasso | 10 | 0.23 | 4.6e-06 | 7.80 | -8.4 | 3.8e-17 | -0.50 | 0.46 | 0.22 | FALSE |
| 18 | GTEx | Brain Hippocampus | RP11-29G8.3 | 0.38 | 0.00 | enet | 30 | 0.01 | 1.5e-01 | 8.11 | -10.4 | 1.9e-25 | -0.59 | 0.05 | 0.52 | FALSE |
| 19 | GTEx | Brain Nucleus accumbens basal ganglia | UCHL3 | 0.42 | 0.37 | lasso | 2 | 0.34 | 4.6e-10 | 7.79 | -7.8 | 6.7e-15 | -0.55 | 0.94 | 0.01 | FALSE |
| 20 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-173B14.5 | 0.26 | 0.32 | lasso | 3 | 0.29 | 1.9e-08 | 7.79 | -8.0 | 1.3e-15 | -0.55 | 0.81 | 0.02 | FALSE |
| 21 | GTEx | Brain Putamen basal ganglia | UCHL3 | 0.29 | 0.25 | lasso | 8 | 0.24 | 1.7e-06 | 7.75 | -8.1 | 4.3e-16 | -0.51 | 0.45 | 0.10 | FALSE |
| 22 | GTEx | Breast Mammary Tissue (Female) | RP11-173B14.5 | 0.01 | 0.07 | lasso | 1 | 0.09 | 1.6e-03 | -5.14 | -5.1 | 2.7e-07 | -0.17 | 0.05 | 0.06 | FALSE |
| 23 | GTEx | Cells Transformed fibroblasts | RP11-173B14.5 | 0.58 | 0.44 | enet | 30 | 0.45 | 4.7e-37 | -5.14 | -6.2 | 6.2e-10 | -0.30 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Colon Sigmoid | UCHL3 | 0.25 | 0.13 | lasso | 7 | 0.08 | 7.7e-04 | -4.89 | -5.2 | 2.3e-07 | -0.12 | 0.30 | 0.05 | TRUE |
| 25 | GTEx | Skin Sun Exposed Lower leg | RP11-173B14.5 | 0.14 | 0.16 | enet | 4 | 0.11 | 3.7e-09 | -5.14 | -6.2 | 4.2e-10 | -0.27 | 1.00 | 0.00 | TRUE |
| 26 | GTEx | Thyroid | RP11-173B14.5 | 0.28 | 0.23 | lasso | 8 | 0.23 | 1.3e-17 | -5.14 | -6.4 | 1.7e-10 | -0.27 | 1.00 | 0.00 | FALSE |
| 27 | YFS | Blood | COMMD6 | 0.05 | 0.03 | bslmm | 541 | 0.04 | 3.3e-12 | -3.75 | 6.3 | 2.6e-10 | 0.21 | 1.00 | 0.00 | FALSE |
| 28 | YFS | Blood | UCHL3 | 0.08 | 0.07 | lasso | 11 | 0.07 | 2.3e-23 | 7.80 | 7.1 | 1.1e-12 | 0.51 | 1.00 | 0.00 | FALSE |
| 29 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | UCHL3 | 0.21 | 0.15 | enet | 13 | 0.12 | 7.2e-06 | 8.11 | -9.0 | 3.0e-19 | -0.61 | 0.14 | 0.59 | FALSE |