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chr13:75,160,653-77,079,702

Best TWAS P=3.87e-51 · Best GWAS P=7.34e-51 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TBC1D4	0.07	0.06	lasso	3	0.06	9.0e-08	15.00	-15.0	3.9e-51	-0.99	0.00	1.00	TRUE
7	GTEx	Artery Tibial	UCHL3	0.20	0.09	lasso	3	0.17	4.1e-13	7.79	-8.5	2.5e-17	-0.49	1.00	0.00	TRUE
4	GTEx	Adipose Visceral Omentum	RP11-173B14.5	0.14	0.05	lasso	5	0.07	2.2e-04	-5.14	-6.5	9.9e-11	-0.19	0.30	0.03	TRUE
16	GTEx	Brain Frontal Cortex BA9	RP11-29G8.3	0.27	0.06	lasso	3	0.08	4.0e-03	-1.17	-6.3	2.5e-10	-0.36	0.12	0.09	TRUE
2	CommonMind	Brain Pre-frontal Cortex	UCHL3	0.27	0.14	lasso	10	0.26	1.1e-31	-0.37	-6.3	3.3e-10	-0.19	1.00	0.00	TRUE
25	GTEx	Skin Sun Exposed Lower leg	RP11-173B14.5	0.14	0.16	enet	4	0.11	3.7e-09	-5.14	-6.2	4.2e-10	-0.27	1.00	0.00	TRUE
3	GTEx	Adipose Subcutaneous	RP11-173B14.5	0.25	0.09	lasso	6	0.07	1.6e-06	-5.14	-5.3	1.0e-07	-0.16	1.00	0.00	TRUE
24	GTEx	Colon Sigmoid	UCHL3	0.25	0.13	lasso	7	0.08	7.7e-04	-4.89	-5.2	2.3e-07	-0.12	0.30	0.05	TRUE
18	GTEx	Brain Hippocampus	RP11-29G8.3	0.38	0.00	enet	30	0.01	1.5e-01	8.11	-10.4	1.9e-25	-0.59	0.05	0.52	FALSE
13	GTEx	Brain Cortex	UCHL3	0.58	0.10	lasso	15	0.09	1.6e-03	7.75	-9.2	4.8e-20	-0.49	0.28	0.06	FALSE
29	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UCHL3	0.21	0.15	enet	13	0.12	7.2e-06	8.11	-9.0	3.0e-19	-0.61	0.14	0.59	FALSE
14	GTEx	Brain Frontal Cortex BA9	UCHL3	0.21	0.07	lasso	8	0.11	9.4e-04	7.79	-8.6	9.1e-18	-0.49	0.12	0.08	FALSE
12	GTEx	Brain Caudate basal ganglia	RP11-173B14.5	0.28	0.20	lasso	8	0.16	2.8e-05	8.11	-8.6	1.0e-17	-0.56	0.30	0.05	FALSE
17	GTEx	Brain Hippocampus	UCHL3	0.44	0.24	lasso	10	0.23	4.6e-06	7.80	-8.4	3.8e-17	-0.50	0.46	0.22	FALSE
21	GTEx	Brain Putamen basal ganglia	UCHL3	0.29	0.25	lasso	8	0.24	1.7e-06	7.75	-8.1	4.3e-16	-0.51	0.45	0.10	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	RP11-173B14.5	0.26	0.32	lasso	3	0.29	1.9e-08	7.79	-8.0	1.3e-15	-0.55	0.81	0.02	FALSE
11	GTEx	Brain Caudate basal ganglia	UCHL3	0.66	0.28	enet	36	0.32	8.1e-10	8.11	-7.9	2.0e-15	-0.49	0.95	0.00	FALSE
8	GTEx	Artery Tibial	TBC1D4	0.20	0.01	enet	27	0.04	3.6e-04	-2.19	-7.8	6.1e-15	-0.58	0.06	0.86	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	UCHL3	0.42	0.37	lasso	2	0.34	4.6e-10	7.79	-7.8	6.7e-15	-0.55	0.94	0.01	FALSE
15	GTEx	Brain Frontal Cortex BA9	RP11-173B14.5	0.23	0.12	lasso	7	0.10	1.5e-03	-5.14	-7.8	7.9e-15	-0.36	0.09	0.20	FALSE
28	YFS	Blood	UCHL3	0.08	0.07	lasso	11	0.07	2.3e-23	7.80	7.1	1.1e-12	0.51	1.00	0.00	FALSE
26	GTEx	Thyroid	RP11-173B14.5	0.28	0.23	lasso	8	0.23	1.3e-17	-5.14	-6.4	1.7e-10	-0.27	1.00	0.00	FALSE
27	YFS	Blood	COMMD6	0.05	0.03	bslmm	541	0.04	3.3e-12	-3.75	6.3	2.6e-10	0.21	1.00	0.00	FALSE
10	GTEx	Artery Tibial	RP11-29G8.3	0.11	0.02	lasso	4	0.04	7.3e-04	7.79	-6.3	3.7e-10	-0.39	0.29	0.04	FALSE
9	GTEx	Artery Tibial	RP11-173B14.5	0.60	0.44	enet	29	0.47	2.0e-40	-5.14	-6.3	3.8e-10	-0.27	1.00	0.00	FALSE
23	GTEx	Cells Transformed fibroblasts	RP11-173B14.5	0.58	0.44	enet	30	0.45	4.7e-37	-5.14	-6.2	6.2e-10	-0.30	1.00	0.00	FALSE
5	GTEx	Artery Aorta	RP11-173B14.4	0.35	0.22	lasso	5	0.20	2.4e-11	-5.14	-5.8	5.1e-09	-0.19	1.00	0.00	FALSE
6	GTEx	Artery Aorta	RP11-173B14.5	0.50	0.43	lasso	5	0.42	3.4e-25	-5.14	-5.2	1.6e-07	-0.17	1.00	0.00	FALSE
22	GTEx	Breast Mammary Tissue (Female)	RP11-173B14.5	0.01	0.07	lasso	1	0.09	1.6e-03	-5.14	-5.1	2.7e-07	-0.17	0.05	0.06	FALSE