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chr1:151,038,920-152,459,124

Best TWAS P=4.12e-09 · Best GWAS P=4.68e-09 conditioned to 0.000404

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	TDRKH	0.21	0.15	lasso	3	0.17	3.5e-09	5.4	5.4	5.4e-08	0.95	0.02	0.98	FALSE
2	GTEx	Artery Aorta	TDRKH	0.19	0.11	enet	16	0.14	7.4e-08	5.4	5.2	2.2e-07	0.91	0.03	0.97	FALSE
3	GTEx	Artery Tibial	TDRKH	0.13	0.14	lasso	7	0.12	1.6e-09	5.8	5.5	3.6e-08	0.98	0.01	0.99	FALSE
4	GTEx	Brain Nucleus accumbens basal ganglia	RP11-98D18.9	0.23	0.22	lasso	3	0.20	3.5e-06	5.4	5.2	1.8e-07	0.95	0.02	0.94	FALSE
5	GTEx	Breast Mammary Tissue (Female)	TDRKH	0.06	0.00	lasso	2	0.10	6.6e-04	5.7	5.6	2.4e-08	0.97	0.02	0.39	FALSE
6	GTEx	Esophagus Mucosa	TDRKH	0.10	0.05	lasso	3	0.06	4.2e-05	3.5	5.2	1.7e-07	0.85	0.02	0.96	FALSE
7	GTEx	Esophagus Muscularis	TDRKH	0.14	0.14	lasso	3	0.14	9.9e-09	5.4	5.4	8.2e-08	0.96	0.03	0.97	FALSE
8	GTEx	Pituitary	RP11-98D18.9	0.41	0.10	lasso	9	0.17	5.9e-05	5.4	5.2	1.7e-07	0.83	0.02	0.89	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	TDRKH	0.13	0.07	lasso	2	0.07	1.2e-04	5.3	5.3	1.4e-07	0.96	0.04	0.96	FALSE
10	GTEx	Skin Sun Exposed Lower leg	TDRKH	0.07	0.04	enet	7	0.03	1.0e-03	5.7	5.7	1.1e-08	0.94	0.01	0.98	FALSE
11	GTEx	Testis	TDRKH	0.12	0.14	lasso	2	0.12	3.7e-06	5.3	5.1	2.9e-07	0.94	0.02	0.96	FALSE
12	GTEx	Thyroid	OAZ3	0.09	0.08	lasso	5	0.10	5.7e-08	5.4	5.3	1.4e-07	0.90	0.01	0.99	FALSE
13	GTEx	Thyroid	RP11-98D18.3	0.12	0.12	enet	11	0.12	2.3e-09	5.4	5.4	6.7e-08	0.95	0.03	0.97	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	LINGO4	0.15	0.03	lasso	4	0.05	8.9e-10	2.6	5.3	8.9e-08	0.33	0.86	0.09	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LINGO4	0.24	0.07	lasso	4	0.11	1.7e-12	2.6	5.9	4.1e-09	0.46	0.56	0.42	TRUE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TDRKH	0.05	0.02	blup	49	0.04	5.0e-05	5.8	5.3	1.1e-07	0.93	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LINGO4	0.24	0.00	enet	10	0.09	9.5e-06	3.5	5.2	2.2e-07	0.56	0.01	0.38	FALSE
18	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TDRKH	0.10	0.05	enet	8	0.07	1.5e-05	5.8	5.2	1.5e-07	0.85	0.01	0.98	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	LINGO4	0.43	0.15	lasso	7	0.20	2.3e-19	2.6	5.4	8.3e-08	0.33	0.99	0.00	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	MRPL9	0.05	0.05	lasso	1	0.04	5.5e-05	5.3	5.3	1.0e-07	0.96	0.02	0.94	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	TDRKH	0.03	0.02	blup	48	0.03	3.1e-04	3.5	5.1	2.7e-07	0.91	0.02	0.83	FALSE