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chr1:153,496,711-156,838,141

Best TWAS P=1.43e-42 · Best GWAS P=7.66e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM46	0.03	0.01	blup	32	0.01	4.9e-03	9.64	13.7	1.4e-42	-0.61	0.01	0.40	TRUE
75	YFS	Blood	MTX1	0.06	0.02	blup	331	0.03	1.9e-10	-10.29	12.0	4.8e-33	-0.66	0.00	1.00	TRUE
78	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	9.75	10.9	1.0e-27	-0.85	0.02	0.47	TRUE
47	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	9.82	-10.6	1.9e-26	0.91	0.01	0.98	TRUE
60	GTEx	Thyroid	FLAD1	0.14	0.09	lasso	7	0.07	9.1e-06	-9.82	-10.4	2.4e-25	0.09	0.19	0.78	TRUE
66	GTEx	Whole Blood	SHC1	0.15	0.08	lasso	4	0.05	8.3e-06	-10.13	-10.3	7.3e-25	-0.01	0.03	0.97	TRUE
97	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GBAP1	0.05	0.04	blup	26	0.04	1.6e-03	-10.29	-10.1	8.2e-24	0.91	0.00	0.94	TRUE
86	The Cancer Genome Atlas	Glioblastoma Multiforme	PBXIP1	0.12	0.01	blup	31	0.05	1.5e-02	-2.43	8.1	3.8e-16	0.03	0.02	0.31	TRUE
1	CommonMind	Brain Pre-frontal Cortex	GBAP1	0.04	0.03	blup	337	0.03	8.6e-05	-4.22	-6.9	4.9e-12	0.81	0.15	0.83	TRUE
30	GTEx	Esophagus Mucosa	ADAM15	0.11	0.02	enet	16	0.04	1.5e-03	8.58	6.5	9.1e-11	0.13	0.58	0.03	TRUE
53	GTEx	Spleen	SHC1	0.22	0.14	lasso	2	0.08	4.0e-03	6.46	6.4	1.4e-10	-0.61	0.06	0.61	TRUE
77	YFS	Blood	UBAP2L	0.28	0.14	bslmm	364	0.17	2.3e-53	5.41	-6.0	2.5e-09	0.00	0.00	1.00	TRUE
48	GTEx	Skin Not Sun Exposed Suprapubic	SEMA4A	0.34	0.31	lasso	2	0.34	3.9e-19	5.37	5.3	1.3e-07	-0.19	0.02	0.98	TRUE
102	The Cancer Genome Atlas	Rectum Adenocarcinoma	UBQLN4	0.25	0.06	blup	33	0.14	3.6e-04	5.80	-5.2	1.8e-07	0.10	0.00	0.68	TRUE
76	YFS	Blood	THBS3	0.29	0.22	enet	38	0.31	6.4e-105	-10.29	13.0	2.0e-38	-0.85	0.00	1.00	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MUC1	0.04	0.01	enet	4	0.02	1.3e-03	9.75	12.8	2.4e-37	-0.78	0.01	0.78	FALSE
2	CommonMind	Brain Pre-frontal Cortex	THBS3	0.12	0.01	enet	23	0.07	5.6e-09	-10.25	12.2	4.3e-34	-0.58	0.01	0.98	FALSE
101	The Cancer Genome Atlas	Prostate Adenocarcinoma	THBS3	0.10	0.12	enet	11	0.10	4.4e-11	-10.25	11.8	2.4e-32	-0.98	0.00	1.00	FALSE
82	The Cancer Genome Atlas	Breast Invasive Carcinoma	THBS3	0.02	0.02	blup	26	0.02	4.0e-05	-10.25	11.7	2.0e-31	-0.93	0.00	0.99	FALSE
45	GTEx	Pancreas	RP11-263K19.4	0.22	0.06	enet	23	0.05	3.1e-03	-10.25	10.8	2.2e-27	-0.68	0.02	0.78	FALSE
24	GTEx	Colon Sigmoid	GBAP1	0.16	0.13	enet	8	0.14	8.4e-06	-10.29	-10.7	6.9e-27	0.97	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAP1	0.03	0.01	blup	26	0.02	1.9e-03	8.56	-10.7	1.1e-26	0.91	0.02	0.91	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	THBS3	0.02	0.03	lasso	4	0.03	2.1e-04	-10.29	10.4	2.4e-25	-0.99	0.00	0.99	FALSE
43	GTEx	Pancreas	THBS3	0.36	0.14	lasso	6	0.12	1.0e-05	-10.25	10.3	4.5e-25	-0.90	0.01	0.98	FALSE
32	GTEx	Esophagus Mucosa	THBS3	0.15	0.15	lasso	2	0.13	6.8e-09	-10.29	10.3	7.0e-25	-1.00	0.00	1.00	FALSE
16	GTEx	Breast Mammary Tissue	GBAP1	0.15	0.17	lasso	2	0.15	5.2e-08	-10.29	-10.3	7.3e-25	1.00	0.00	1.00	FALSE
95	The Cancer Genome Atlas	Lung Adenocarcinoma	GBAP1	0.02	0.03	enet	2	0.02	2.3e-03	-10.29	-10.3	7.3e-25	1.00	0.00	0.95	FALSE
40	GTEx	Nerve Tibial	GBAP1	0.12	0.14	lasso	1	0.14	8.9e-10	-10.29	-10.3	7.9e-25	1.00	0.00	1.00	FALSE
98	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM46	0.08	0.08	lasso	2	0.07	2.1e-05	-10.29	10.3	7.9e-25	-1.00	0.00	0.99	FALSE
35	GTEx	Esophagus Mucosa	RP11-263K19.4	0.14	0.14	lasso	4	0.12	1.5e-08	-10.29	10.3	8.4e-25	-1.00	0.00	1.00	FALSE
9	GTEx	Brain Cerebellar Hemisphere	THBS3	0.19	0.26	lasso	2	0.24	8.6e-07	-10.25	10.3	9.0e-25	-0.99	0.00	0.99	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	SLC50A1	0.06	0.02	bslmm	331	0.03	4.3e-05	9.75	10.3	1.2e-24	-0.52	0.06	0.90	FALSE
46	GTEx	Prostate	GBAP1	0.47	0.30	lasso	7	0.32	1.1e-08	-10.29	-10.2	1.3e-24	0.96	0.01	0.99	FALSE
6	GTEx	Artery Aorta	GBAP1	0.31	0.36	enet	22	0.39	1.0e-22	-10.29	-10.2	2.5e-24	0.94	0.00	1.00	FALSE
52	GTEx	Small Intestine Terminal Ileum	GBAP1	0.20	0.13	lasso	10	0.11	1.8e-03	8.57	-10.1	4.4e-24	0.93	0.02	0.89	FALSE
39	GTEx	Lung	THBS3	0.11	0.07	lasso	4	0.04	1.0e-03	-10.29	10.1	4.6e-24	-0.99	0.00	1.00	FALSE
85	The Cancer Genome Atlas	Esophageal Carcinoma	FAM189B	0.36	0.05	lasso	3	0.02	6.1e-02	-10.29	-10.1	4.6e-24	1.00	0.00	0.67	FALSE
67	GTEx	Whole Blood	THBS3	0.17	0.20	enet	5	0.21	1.0e-18	-10.29	10.1	8.0e-24	-0.99	0.00	1.00	FALSE
33	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	9.75	10.1	9.0e-24	-0.81	0.29	0.71	FALSE
5	GTEx	Adipose Visceral Omentum	GBAP1	0.07	0.11	enet	5	0.10	5.0e-06	-10.29	-10.0	1.7e-23	0.99	0.00	0.99	FALSE
69	GTEx	Whole Blood	RP11-263K19.4	0.15	0.17	lasso	4	0.17	9.5e-16	-10.29	10.0	2.1e-23	-0.99	0.00	1.00	FALSE
61	GTEx	Thyroid	GBAP1	0.23	0.28	lasso	10	0.27	4.6e-21	-10.25	-9.9	2.8e-23	0.99	0.00	1.00	FALSE
36	GTEx	Esophagus Muscularis	GBAP1	0.09	0.13	enet	4	0.12	8.9e-08	-8.99	-9.9	5.1e-23	0.99	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	GBAP1	0.10	0.10	lasso	3	0.08	6.1e-07	-9.51	-9.8	7.5e-23	0.97	0.00	1.00	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	THBS3	0.14	0.03	enet	16	0.08	3.8e-08	-10.25	9.8	1.8e-22	-0.72	0.00	0.99	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	GBAP1	0.22	0.19	enet	6	0.17	6.8e-07	-9.51	-9.7	3.4e-22	0.97	0.01	0.99	FALSE
25	GTEx	Colon Transverse	GBAP1	0.13	0.15	lasso	5	0.11	6.4e-06	-10.29	-9.7	4.7e-22	0.99	0.00	1.00	FALSE
55	GTEx	Spleen	THBS3	0.23	0.10	enet	17	0.08	4.6e-03	6.46	9.5	1.9e-21	-0.80	0.03	0.86	FALSE
8	GTEx	Artery Tibial	GBAP1	0.21	0.26	lasso	7	0.26	1.3e-20	-10.29	-9.5	2.0e-21	0.97	0.00	1.00	FALSE
57	GTEx	Testis	THBS3	0.11	0.11	lasso	2	0.09	1.2e-04	-8.99	9.3	1.3e-20	-0.96	0.01	0.99	FALSE
26	GTEx	Colon Transverse	THBS3	0.11	0.09	lasso	4	0.09	5.9e-05	-10.29	9.3	1.5e-20	-0.95	0.01	0.99	FALSE
38	GTEx	Lung	GBAP1	0.16	0.16	lasso	5	0.15	1.6e-11	-8.99	-9.3	2.0e-20	0.96	0.02	0.98	FALSE
51	GTEx	Skin Sun Exposed Lower leg	RP11-263K19.4	0.04	0.01	enet	9	0.01	3.3e-02	-10.29	9.2	2.4e-20	-0.98	0.01	0.97	FALSE
22	GTEx	Cells Transformed fibroblasts	GBAP1	0.18	0.16	lasso	6	0.15	1.6e-11	-10.29	-9.2	3.9e-20	0.99	0.00	1.00	FALSE
12	GTEx	Brain Cerebellum	THBS3	0.17	0.15	enet	6	0.16	2.0e-05	-10.25	9.2	4.4e-20	-0.90	0.01	0.98	FALSE
59	GTEx	Testis	RP11-263K19.4	0.08	0.12	lasso	2	0.10	2.4e-05	-8.99	9.1	9.0e-20	-0.95	0.01	0.98	FALSE
13	GTEx	Brain Cerebellum	EFNA1	0.20	0.09	enet	13	0.06	9.2e-03	8.56	-9.0	2.0e-19	0.90	0.02	0.96	FALSE
10	GTEx	Brain Cerebellar Hemisphere	EFNA1	0.33	0.04	enet	7	0.08	4.5e-03	-8.99	-8.8	9.3e-19	0.90	0.02	0.67	FALSE
4	GTEx	Adipose Subcutaneous	GBA	0.08	0.03	lasso	3	0.02	8.9e-03	-9.51	-8.6	5.4e-18	0.94	0.02	0.92	FALSE
20	GTEx	Breast Mammary Tissue (Female)	FAM189B	0.05	-0.01	lasso	2	0.00	4.8e-01	8.52	-8.6	1.2e-17	0.66	0.03	0.25	FALSE
41	GTEx	Nerve Tibial	GBA	0.14	0.02	lasso	5	0.01	3.3e-02	-10.29	-8.5	1.4e-17	0.96	0.01	0.98	FALSE
42	GTEx	Pancreas	GBAP1	0.12	0.17	enet	10	0.14	2.4e-06	-8.99	-8.5	1.8e-17	0.92	0.01	0.99	FALSE
23	GTEx	Cells Transformed fibroblasts	SLC50A1	0.08	0.07	lasso	6	0.07	3.9e-06	8.56	8.4	4.5e-17	-0.76	0.37	0.61	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	GBAP1	0.02	0.01	blup	24	0.02	3.0e-03	-10.29	-8.4	5.8e-17	0.88	0.01	0.79	FALSE
94	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAG1AP1	0.07	0.05	blup	77	0.05	3.8e-06	7.90	8.3	7.9e-17	-0.82	0.33	0.66	FALSE
58	GTEx	Testis	MUC1	0.20	0.02	lasso	7	0.07	7.5e-04	9.82	8.3	8.5e-17	-0.58	0.03	0.91	FALSE
14	GTEx	Brain Cortex	GBAP1	0.25	0.14	enet	25	0.23	4.7e-07	-9.51	8.3	1.3e-16	-0.88	0.02	0.98	FALSE
89	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	THBS3	0.04	0.01	blup	25	0.03	3.1e-04	7.15	8.1	4.1e-16	-0.80	0.02	0.80	FALSE
37	GTEx	Heart Left Ventricle	GBAP1	0.18	0.22	enet	13	0.18	1.1e-09	-8.99	-8.1	4.2e-16	0.94	0.02	0.98	FALSE
44	GTEx	Pancreas	GBA	0.12	0.05	enet	10	0.02	4.2e-02	-10.29	-8.1	4.4e-16	0.90	0.02	0.95	FALSE
54	GTEx	Spleen	GBAP1	0.33	0.23	enet	20	0.28	7.9e-08	-9.51	-8.1	4.8e-16	0.87	0.01	0.98	FALSE
96	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GBAP1	0.04	0.02	blup	27	0.03	4.7e-04	-10.29	-8.1	7.7e-16	0.86	0.00	0.93	FALSE
31	GTEx	Esophagus Mucosa	GBAP1	0.12	0.12	enet	22	0.09	1.7e-06	-10.29	-8.0	1.1e-15	0.93	0.00	1.00	FALSE
84	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GBAP1	0.10	0.06	enet	9	0.04	5.1e-03	-10.29	-8.0	1.4e-15	0.89	0.00	0.84	FALSE
7	GTEx	Artery Coronary	MTX1	0.24	-0.01	lasso	10	0.00	3.3e-01	-2.48	-7.9	3.3e-15	-0.03	0.06	0.22	FALSE
80	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBAP1	0.02	0.03	lasso	4	0.03	1.3e-07	-10.29	-7.8	4.3e-15	0.91	0.00	1.00	FALSE
62	GTEx	Thyroid	THBS3	0.12	0.09	enet	8	0.09	3.6e-07	-9.51	7.8	9.3e-15	-0.87	0.01	0.99	FALSE
73	NTR	Blood	THBS3	0.03	0.02	blup	341	0.02	2.8e-08	-10.25	7.7	1.6e-14	-0.77	0.01	0.99	FALSE
65	GTEx	Vagina	GBAP1	0.27	0.08	lasso	7	0.17	1.3e-04	6.46	-7.6	2.2e-14	0.86	0.03	0.89	FALSE
18	GTEx	Breast Mammary Tissue (Male)	GBAP1	0.28	0.11	enet	18	0.08	7.3e-03	-10.25	-7.6	3.1e-14	0.77	0.01	0.84	FALSE
81	The Cancer Genome Atlas	Breast Invasive Carcinoma	LENEP	0.01	0.00	blup	37	0.01	1.6e-03	0.54	-7.6	3.5e-14	0.00	0.01	0.53	FALSE
15	GTEx	Brain Frontal Cortex BA9	MTX1P1	0.20	0.05	enet	21	0.01	1.5e-01	7.35	7.5	6.4e-14	-0.73	0.04	0.56	FALSE
72	METSIM	Adipose	THBS3	0.09	0.10	lasso	7	0.12	4.7e-17	-10.29	7.4	1.4e-13	-0.92	0.00	1.00	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	GBAP1	0.06	0.06	lasso	9	0.06	3.5e-07	8.56	-7.2	5.0e-13	0.80	0.18	0.82	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GBAP1	0.04	0.04	blup	26	0.04	2.5e-05	8.56	-7.2	8.3e-13	0.85	0.06	0.89	FALSE
56	GTEx	Stomach	GBAP1	0.09	0.12	lasso	3	0.13	1.2e-06	-8.99	-6.6	3.8e-11	0.88	0.08	0.92	FALSE
27	GTEx	Colon Transverse	GBA	0.06	0.09	enet	8	0.08	7.9e-05	2.54	-6.5	8.0e-11	0.87	0.01	0.98	FALSE
28	GTEx	Colon Transverse	RP11-263K19.4	0.14	0.09	enet	10	0.10	1.2e-05	-10.25	6.5	1.0e-10	-0.73	0.01	0.98	FALSE
11	GTEx	Brain Cerebellum	MSTO1	0.15	0.06	enet	13	0.07	4.0e-03	8.57	6.5	1.1e-10	-0.80	0.07	0.76	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	GBAP1	0.21	0.05	lasso	3	0.06	4.5e-03	-9.51	-6.3	2.2e-10	0.86	0.02	0.97	FALSE
63	GTEx	Thyroid	MUC1	0.11	0.02	enet	15	0.09	1.5e-07	-1.48	-6.3	2.9e-10	0.62	0.29	0.71	FALSE
79	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBA	0.03	0.00	blup	26	0.02	3.1e-04	1.68	-6.3	3.0e-10	0.80	0.01	0.87	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCST2	0.04	0.01	blup	50	0.03	2.0e-04	0.67	6.2	5.3e-10	-0.03	0.05	0.80	FALSE
70	METSIM	Adipose	DCST2	0.04	0.04	enet	12	0.04	4.3e-07	5.88	-6.0	2.7e-09	0.12	0.90	0.06	FALSE
19	GTEx	Breast Mammary Tissue (Female)	GBAP1	0.12	0.02	enet	6	0.02	1.0e-01	-4.22	-5.9	4.7e-09	0.71	0.04	0.52	FALSE
92	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	THBS3	0.04	0.02	enet	8	0.01	4.5e-02	8.56	5.8	8.0e-09	-0.74	0.02	0.43	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEMA4A	0.11	0.08	blup	51	0.08	7.1e-09	5.39	5.7	1.5e-08	-0.28	0.00	1.00	FALSE
64	GTEx	Thyroid	SEMA4A	0.48	0.31	lasso	5	0.30	5.8e-23	5.39	5.6	2.3e-08	-0.20	0.02	0.98	FALSE
49	GTEx	Skin Sun Exposed Lower leg	ADAM15	0.14	0.09	lasso	4	0.08	6.1e-07	-4.93	5.5	4.4e-08	-0.09	0.96	0.00	FALSE
68	GTEx	Whole Blood	SEMA4A	0.10	0.13	enet	3	0.13	3.7e-12	5.37	5.3	1.1e-07	-0.19	0.02	0.98	FALSE
50	GTEx	Skin Sun Exposed Lower leg	SEMA4A	0.51	0.36	enet	3	0.39	3.7e-34	5.39	5.3	1.3e-07	-0.19	0.02	0.98	FALSE
17	GTEx	Breast Mammary Tissue	SEMA4A	0.20	0.17	lasso	3	0.16	9.4e-09	5.39	5.2	1.9e-07	-0.19	0.02	0.98	FALSE
71	METSIM	Adipose	SEMA4A	0.18	0.13	bslmm	363	0.13	1.8e-18	5.39	5.2	2.0e-07	-0.22	0.02	0.98	FALSE
34	GTEx	Esophagus Mucosa	SEMA4A	0.37	0.30	lasso	4	0.33	1.1e-22	4.97	5.2	2.1e-07	-0.20	0.03	0.97	FALSE