Hub : Genes

OAZ3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3700	0.1160	3.0e-03	0.040	NA	0.090	NA	0.024	2.5e-02	NA	1.3e-03	NA	6.3e-02
2	GTEx	Cells Transformed fibroblasts	0.1010	0.0460	1.3e-03	0.096	NA	0.073	NA	0.082	1.1e-07	NA	4.1e-06	NA	1.0e-06
3	GTEx	Pituitary	0.2910	0.1020	2.5e-03	0.101	NA	0.121	NA	0.102	1.6e-03	NA	6.1e-04	NA	1.6e-03
4	GTEx	Thyroid	0.0940	0.0310	3.8e-05	0.085	NA	0.095	NA	0.099	5.1e-07	NA	9.2e-08	NA	5.7e-08
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0523	0.0301	4.4e-03	0.012	0.018	0.011	NA	0.010	1.4e-02	3.4e-03	2.0e-02	NA	2.1e-02
6	TCGA	Thyroid Carcinoma	0.1150	0.0520	5.8e-03	0.052	0.042	0.052	NA	0.047	8.7e-06	5.5e-05	8.5e-06	NA	2.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.1	4.8	0.9	-2.0	1.3	0.9	2.2	-0.1
Bipolar Disorder or Schizophrenia	0.8	1.9	5.0	0.1	-1.4	1.9	0.8	2.2	0.6
Depressed Affect (Nagel 2018)	0.5	1.0	3.7	-1.9	-0.3	-0.5	-0.5	-0.8	-1.1
Depression (Nagel 2018)	1.1	1.6	3.4	-0.3	-1.6	1.0	1.8	-1.5	-0.8
Intelligence (Savage-Jansen 2018)	0.7	2.0	6.2	1.1	-1.4	2.5	1.6	-0.2	0.1
Neuroticism (Nagel 2018)	0.7	1.5	3.5	-1.9	-0.8	0.1	0.7	-1.8	-1.1
Schizophrenia (2018)	0.4	0.8	2.0	-0.8	-0.2	1.4	0.2	1.1	0.9
Schizophrenia vs Biploar Disorder	1.4	1.9	8.9	-0.4	0.6	0.2	1.3	-3.0	0.2
Worry (Nagel 2018)	0.8	1.6	3.6	-0.4	-1.5	0.4	1.8	-1.9	-0.7
Alzheimer’s Disease (in mother)	0.6	0.7	3.1	-0.5	0.3	0.7	0.7	-1.8	0.1
Alzheimer’s Disease (in father)	0.7	0.8	2.2	0.0	-1.3	0.5	0.1	-0.6	-1.5
Alzheimer’s Disease (including proxy)	0.7	1.1	3.1	-0.8	-0.3	-0.5	-0.6	-1.8	-1.4
Crohns Disease (2017)	2.1	4.6	8.9	-0.8	3.0	2.9	0.1	-2.0	2.4
Irritable Bowel Disease (IBD)	2.7	6.3	14.4	-1.0	1.9	3.8	1.6	-3.5	2.0
Ulcerative Colitis (UC)	2.4	4.6	12.8	-0.6	0.2	3.6	2.0	-3.1	0.9
Major Depression (MDD)	1.0	1.2	2.8	1.2	-0.9	0.1	1.7	-1.4	-0.3
Reaction Time	0.9	1.6	3.7	-1.3	0.9	0.9	-1.3	1.9	1.1
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.6	0.5	-0.7	2.2	2.1	-1.0	0.8
Breast Cancer	0.2	0.4	1.3	0.7	-0.4	-1.1	0.0	0.7	-0.1
Ovarian Cancer	1.6	2.1	5.6	-0.8	1.4	-0.2	-1.6	2.4	1.3
Prostate Cancer	2.2	3.1	6.6	1.2	-0.1	-2.1	-2.5	2.6	-0.2
Age at First Birth	2.3	3.3	6.4	1.8	-2.5	2.1	2.5	0.2	-0.3
Bipolar Disorder (2011)	1.4	1.4	6.0	1.0	-1.1	0.0	-0.5	2.4	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.6	-0.3	-0.0	-0.8	0.1	0.1	-0.4
Coronary Artery Disease (CAD)	1.3	1.5	5.6	0.5	0.2	0.7	1.6	-2.4	0.5
Crohns Disease (2012)	1.0	1.7	4.2	-0.9	2.0	1.2	-0.5	-1.3	1.2
Mean Putamen Volume	0.3	0.4	1.0	-0.3	-0.7	0.8	1.0	-0.0	0.1
Fasting Glucose	0.6	0.7	1.9	-0.7	0.5	-0.0	-1.4	1.2	-0.1
HbA1C	1.0	1.1	2.5	-1.3	-0.5	-0.9	-1.6	0.9	-0.9
HDL Cholesterol	0.7	1.1	2.4	1.5	-1.5	0.4	0.9	-0.5	-0.9
LDL Cholesterol	0.7	1.1	2.4	1.0	1.1	-0.3	1.0	-0.8	1.6
Lupus	2.3	3.5	5.6	2.4	-2.2	-0.3	2.2	-1.9	-1.5
Neuroticism (2016)	1.4	2.0	6.0	-0.5	-0.6	1.6	2.5	-1.6	0.7
Primary Biliary Cirrhosis	0.7	1.1	3.2	0.8	-1.8	-0.4	1.2	0.7	-0.7
Rheumatoid Arthritis	0.9	1.2	2.8	-0.2	-0.7	-1.7	-1.3	0.1	-1.5
Schizophrenia (2014)	0.5	1.1	3.0	-0.3	-0.7	1.7	0.6	1.5	0.8
Triglycerides	1.3	2.1	4.8	-1.5	0.9	-0.7	-1.9	2.2	0.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.5	-0.7	1.9	0.3	-0.5	0.3	1.3
Ulcerative Colitis	2.5	3.6	11.3	-0.7	0.4	3.4	2.2	-1.4	1.7
Blood Eosinophil Count	0.5	3.6	6.7	0.7	-1.8	-2.6	1.4	-2.2	-2.1
Blood Platelet Count	0.5	5.2	13.0	-1.8	2.4	-3.6	-2.5	1.5	0.9
Blood Red Count	1.1	10.5	27.7	3.1	-2.3	3.7	5.3	-2.5	1.0
Blood White Count	0.3	2.0	3.6	-0.9	1.5	-0.1	1.9	-1.9	1.5
Heel T-Score	1.2	9.8	28.0	2.3	1.6	5.3	2.7	-0.8	3.9
BMI	0.5	2.9	10.2	-3.2	2.0	-1.2	-0.5	-0.8	0.7
Height	0.4	7.0	13.6	-3.4	2.9	-0.1	-3.7	2.6	1.2
Waist Hip Ratio (WHR)	0.6	2.9	6.8	-2.0	1.1	1.5	1.5	-2.6	1.0
Systolic Blood Pressure	0.3	1.6	3.2	1.7	-1.6	-0.4	1.8	-0.7	-0.7
Smoking Status	0.9	2.2	5.6	-2.4	1.1	-1.4	-2.0	-0.6	-0.7
Allergy or Eczema	1.7	4.5	14.4	-0.4	-0.8	2.9	1.7	-3.8	-0.9
Cardiovascular Disease	0.7	2.2	7.1	1.4	-1.1	0.4	1.4	-2.7	-1.0
Hypothyroidism (self reported)	2.0	4.6	9.9	0.8	-1.6	3.1	2.9	-2.5	0.3
Respiratory disease	0.9	1.9	4.0	-0.9	2.0	-1.0	-1.6	-1.7	-0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	-1.3	0.7	1.1	0.2	-0.3	0.8
Lung FEV1/FVC ratio	0.0	0.1	0.2	0.3	0.1	0.4	0.4	-0.0	0.4
Lung FVC	1.0	5.0	10.9	3.3	-3.3	-1.8	0.6	0.9	-2.0
Neuroticism	0.7	1.6	2.9	-0.5	-1.7	0.6	1.3	-1.7	-1.3
Chronotype (morning person)	1.8	4.2	8.8	-2.6	3.0	-0.1	-2.7	0.5	1.2
Hair Pigment	0.1	2.0	3.8	-2.0	1.1	-1.7	-1.6	1.3	0.3
Tanning	0.1	1.8	6.2	0.8	0.4	-2.5	-1.8	-0.1	-0.9
Hand grip strength (left)	0.2	0.6	1.7	-0.6	1.3	-0.6	-0.2	-0.5	0.8
Number of treatments/medications taken	0.3	0.6	2.0	-0.4	0.1	1.1	0.4	-1.4	-0.0
Average weekly spirits intake	1.9	2.4	5.1	0.3	-0.8	-2.0	-0.1	-2.1	-2.2
Sensitivity / hurt feelings	0.5	0.9	2.2	-1.4	0.3	-0.2	0.9	-1.5	0.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	-0.2	-0.4	0.6	0.7	-0.8	-0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.3	-0.9	1.1	-0.4	-1.0	-0.3	0.5
Relative age of first facial hair	0.2	0.4	0.8	-0.6	-0.9	-0.5	-0.1	-0.5	-0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.7	-0.0	0.1	1.6	-0.6	-0.4	-0.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.4	-0.9	0.4	-0.7	-1.1	-1.2	-0.8
Ever had hysterectomy (womb removed)	0.9	1.0	1.8	1.3	-0.9	-1.2	0.8	-0.3	-1.2
Systolic blood pressure, automated reading	0.3	1.0	3.0	1.3	-0.9	0.4	1.7	0.2	0.3
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.2	0.9	1.1	1.8	1.3	-1.1	1.7
Angina	2.0	2.6	3.6	-1.6	1.0	1.9	1.9	-1.4	1.7
Medication for hormone replacement therapy	1.4	1.6	5.6	-0.4	-0.5	-2.4	-1.3	0.6	-1.2
Vitamin and mineral supplements	1.3	1.8	3.4	1.9	1.3	-0.8	-0.6	1.6	1.5
Supplements: Zinc	1.0	1.1	3.4	0.0	-0.5	-0.7	-0.4	-1.8	-1.5
Medication: Co-codamol	1.6	1.8	4.8	0.4	2.2	-0.9	-1.1	1.0	1.7
Medication: Metformin	1.3	1.8	4.3	-1.0	2.1	1.3	0.0	0.1	2.0
Diabetes (father)	0.7	0.8	2.6	-0.8	-0.5	0.7	0.6	-1.6	-0.8
Diabetes (mother)	0.4	0.5	1.5	-0.1	-0.8	0.3	1.2	-0.9	-0.3
Severe depression (siblings)	1.5	1.7	8.3	-0.1	-0.5	2.9	0.9	-0.2	0.8
Pack years adult smoking proportion	0.3	0.5	1.2	-1.1	-0.0	-0.4	0.2	-1.0	-0.8
Impedance of leg (right)	0.6	3.0	9.1	1.0	1.4	3.0	1.0	0.0	2.2
Leg fat-free mass (left)	0.7	3.7	10.7	-3.3	2.2	-1.5	-2.0	0.4	0.4
Trunk fat percentage	0.6	2.5	8.3	-2.9	1.8	-0.2	-0.8	-1.7	-0.2
Hand grip strength (right)	0.1	0.1	0.4	-0.2	0.6	-0.5	-0.4	-0.4	-0.0
Townsend deprivation index at recruitment	1.5	2.1	5.6	-1.9	2.4	0.7	-1.4	-0.2	1.0
Current tobacco smoking	1.3	2.2	4.7	-1.4	1.6	-1.6	-2.2	-1.2	-0.3
Average weekly fortified wine intake	0.7	0.9	4.1	-2.0	-0.5	-0.2	-0.2	-0.1	-0.9
Maternal smoking around birth	0.9	1.3	3.3	-1.3	0.7	-1.1	-0.4	-1.8	-0.9
Fed-up feelings	0.2	0.3	0.8	-0.7	0.1	-0.2	-0.3	-0.9	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.0	-1.5	0.4	-0.2	0.4	-2.0	-0.3
Relative age voice broke	0.1	0.2	0.4	-0.6	-0.7	-0.5	0.1	0.1	-0.4
Taking other prescription medications	0.6	0.9	1.7	0.5	0.6	1.3	1.1	-1.0	1.0
Age when periods started (menarche)	0.5	1.3	3.8	1.2	-0.3	-1.2	0.5	-2.0	-0.8
Bilateral oophorectomy (both ovaries removed)	2.9	3.4	10.3	0.1	-1.7	-1.7	0.4	-2.1	-3.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	4.5	1.8	-0.3	2.1	0.8	-0.4	0.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.2	-0.2	-0.7	0.1	1.5	-1.8	-0.7
Qualifications: CSEs or equivalent	1.6	2.2	3.4	-1.3	1.2	-1.4	-1.8	-1.9	-1.2
Serious illness, injury or assault to yourself	0.8	1.0	2.7	0.6	-0.6	0.6	1.4	-1.7	0.0
High blood pressure	0.5	1.4	6.1	0.2	-0.0	0.5	1.4	-2.5	-0.1
Hayfever, allergic rhinitis or eczema	1.5	3.2	9.7	-1.0	-0.4	3.1	1.5	-2.5	0.0
Multivitamins +/- minerals	1.4	1.8	3.8	-1.0	-1.8	0.3	0.4	-1.6	-2.0
Stomach or abdominal pain in last month	0.9	1.1	2.7	1.3	-0.9	0.6	1.7	-1.0	-0.4
Supplements: Glucosamine	0.8	1.1	2.8	0.3	-1.2	-1.3	-0.0	-0.8	-1.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	0.8	-0.3	-1.1	-0.7	-0.7	-1.1
Medication: Atenolol	0.7	0.8	2.5	0.7	0.3	0.6	1.1	0.2	1.6
Medication: Levothyroxine sodium	0.4	0.6	2.1	-0.8	-0.2	1.4	-0.3	0.8	0.5
Sitting height	0.6	4.6	9.2	-2.1	3.0	0.3	-2.0	2.0	2.3
Chronic bronchitis/emphysema (father)	1.1	1.3	5.3	-2.3	1.1	0.2	-0.3	-1.1	0.2
High blood pressure (mother)	0.7	1.0	3.1	-0.6	-0.6	0.6	1.8	-1.2	0.0
Body mass index (BMI)	0.5	2.3	8.6	-2.9	1.4	-1.2	-1.2	-0.5	-0.1
Impedance of leg (left)	0.4	2.0	6.0	0.7	1.3	2.5	0.7	-0.1	1.9
Leg predicted mass (left)	0.7	3.7	10.6	-3.2	2.3	-1.5	-2.0	0.4	0.4
Trunk fat mass	0.8	3.3	12.4	-3.5	2.2	-0.3	-1.1	-1.2	0.2
Waist circumference	0.8	3.0	11.5	-3.4	2.1	-0.6	-0.8	-0.9	0.7
Number of incorrect matches in round	0.4	0.7	1.9	1.4	-0.4	-0.8	-0.7	0.6	-0.7
Past tobacco smoking	0.1	0.2	0.9	1.0	-0.0	-0.5	0.0	-0.2	0.0
Alcohol usually taken with meals	1.3	2.2	5.6	1.3	-2.4	0.9	2.2	0.3	-0.2
Nervous feelings	0.9	1.7	4.4	1.2	-1.5	0.4	2.1	-1.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.5	0.7	0.3	-1.2	-0.1	-0.2	0.2
Hearing difficulty/problems with background noise	0.6	1.0	4.0	1.0	0.8	0.2	0.6	0.2	2.0
Hair/balding pattern: Pattern 2	1.2	1.5	3.5	-1.1	-0.8	-1.6	-1.2	-0.4	-1.9
Had menopause	0.6	0.8	1.4	0.0	0.6	1.2	-0.3	1.2	1.1
Had other major operations	1.4	1.7	7.1	1.3	0.3	-0.1	-0.8	2.7	0.5
Forced vital capacity (FVC)	0.0	0.2	0.5	0.7	-0.4	-0.4	0.1	0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.6	1.6	-0.4	1.4	0.4	-0.5	0.0
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.9	1.6	-1.0	1.4	1.7	-0.2	0.2
Qualifications: None of the above	0.3	0.6	1.7	-0.4	-0.1	-1.3	-0.1	-1.0	-0.9
Financial difficulties in last 2 years	0.5	0.6	3.2	-0.4	0.6	0.0	0.3	-1.8	-0.1
Mouth/teeth dental problems	1.4	2.2	5.9	1.7	-1.2	0.8	1.0	-2.4	-1.2
Heart attack	1.0	1.2	3.1	-1.7	0.0	1.8	0.7	-0.8	0.1
Allergy	1.3	3.1	9.3	1.4	-0.4	-3.0	-0.9	2.4	-0.5
Pain all over the body in last month	1.0	1.1	4.3	0.5	0.1	2.1	1.1	-0.6	0.5
Diabetes (self-reported)	1.3	2.0	4.5	-1.9	1.2	2.1	0.5	-0.3	1.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	6.8	-0.2	-0.7	0.6	1.9	-2.6	-0.4
Medication: Ramipril	1.3	1.7	4.0	-1.4	1.9	-0.4	-0.1	-2.0	0.5
Medication: Simvastatin	0.2	0.4	1.3	0.6	-0.1	0.2	0.7	-1.1	-0.1
Fluid intelligence score	1.6	3.4	7.7	2.1	-1.6	2.2	2.8	-0.8	0.4
Illnesses of siblings	0.7	0.9	1.7	-0.3	1.3	-0.0	-0.7	1.3	1.3
Neuroticism score	0.6	1.3	4.5	-1.3	-0.4	-0.3	0.5	-2.1	-1.0
Weight	1.0	4.9	15.8	-4.0	2.8	-1.0	-2.0	0.4	0.9
Impedance of arm (right)	0.3	1.6	6.8	1.0	0.7	2.6	0.4	-0.9	0.7
Arm fat percentage (right)	0.7	2.7	9.6	-3.1	1.8	-0.2	-1.0	-1.4	0.1
Trunk fat-free mass	0.8	4.7	12.1	-3.5	2.5	-1.3	-2.0	1.6	1.2
Hip circumference	0.5	2.3	6.7	-2.6	1.8	-0.9	-1.6	0.6	0.5
Time employed in main current job	1.0	1.2	2.2	0.4	-1.2	-0.7	1.5	-1.2	-1.1
Alcohol intake versus 10 years previously	1.2	1.8	3.8	-1.6	1.9	-0.9	-1.9	-0.2	0.2
Father’s age at death	0.3	0.4	1.3	-0.6	0.2	1.1	0.1	0.1	0.7
Worrier / anxious feelings	2.1	4.0	7.8	1.1	-2.5	-0.3	2.3	-2.8	-1.8
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	5.6	-0.2	-1.0	-0.8	0.3	-2.4	-1.8
Falls in the last year	1.0	1.3	5.0	0.0	0.8	2.2	0.6	-0.4	1.3
Hair/balding pattern: Pattern 3	0.5	0.7	2.4	1.6	-0.3	0.2	-0.8	1.1	-0.1
Number of live births	0.9	1.3	4.3	0.9	0.2	0.2	-1.6	2.1	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.9	1.4	-0.3	-0.0	0.5	-0.0	0.3
Pulse rate	0.9	1.4	3.7	0.5	0.5	1.9	1.1	-1.6	0.8
Happiness	1.2	1.5	2.4	0.9	-1.5	-0.4	1.4	-1.5	-1.2
Noisy workplace	0.8	1.0	2.8	0.0	1.7	-0.7	-1.5	0.5	0.7
Qualifications: A levels/AS levels or equivalent	0.7	1.6	6.0	-0.2	-0.1	2.4	0.7	1.2	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.4	-0.0	-0.4	-0.5	-0.5	-0.6
Mouth/teeth dental problems: Dentures	1.8	3.1	8.6	-1.3	1.6	-0.3	-1.9	2.9	1.4
Asthma	0.8	1.7	5.8	-0.6	2.4	0.3	-1.1	-1.4	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.5	-0.4	-0.7	-0.0	0.6	-1.9	-1.2
Medication: Cholesterol lowering	1.0	1.5	6.0	0.2	1.0	0.1	1.2	-2.4	0.8
Depression (self-reported)	0.8	1.0	3.0	-0.1	0.3	0.7	1.4	-1.7	0.4
Medication: Lansoprazole	0.6	0.7	2.2	0.1	-0.1	-0.9	-0.9	1.5	-0.2
Prospective memory result	1.4	1.8	4.5	-1.2	1.2	-0.4	-1.6	2.1	0.8
Lung cancer (father)	1.4	1.6	3.6	-0.3	1.9	0.1	-1.6	1.2	1.3
Illnesses of mother	2.3	2.8	7.1	-0.9	1.5	-1.6	-2.7	2.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.9	1.7	-0.3	0.2	0.6	0.2	0.5
Pulse wave Arterial Stiffness index	1.2	1.4	3.1	-0.2	-0.8	-1.4	-0.3	-1.6	-1.7
Impedance of arm (left)	0.2	1.1	4.4	1.1	0.3	2.1	0.4	-0.8	0.4
Arm fat mass (right)	0.7	3.1	11.0	-3.3	2.2	-0.6	-1.3	-0.8	0.4
Trunk predicted mass	0.9	4.9	12.8	-3.6	2.6	-1.4	-2.0	1.6	1.2
Standing height	0.5	4.6	9.7	-2.5	3.1	0.5	-1.7	1.8	2.2
Length of working week for main job	2.7	3.0	6.5	-2.5	2.2	-0.9	-2.1	0.7	1.0
Exposure to tobacco smoke at home	0.8	0.9	3.0	-1.2	0.1	-0.0	1.1	-1.7	-0.2
Breastfed as a baby	3.3	4.0	9.3	3.1	-2.0	1.9	2.5	-0.9	-0.3
Tense / ‘highly strung’	0.5	0.8	3.8	-2.0	-0.0	0.2	0.6	-0.7	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	6.2	0.8	-1.4	2.0	2.5	-2.4	-0.6
Hair/balding pattern: Pattern 4	1.6	4.0	12.1	0.6	-0.6	3.5	2.9	0.1	1.6
Birth weight of first child	0.2	0.4	0.7	-0.5	-0.8	0.3	0.9	-0.8	-0.3
Peak expiratory flow (PEF)	0.3	0.8	1.6	1.2	-0.4	0.5	1.2	-1.0	0.4
Pulse wave reflection index	1.1	1.4	3.6	-0.2	-1.6	-1.2	0.4	-0.9	-1.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.5	-0.2	-0.7	0.1	-0.3	-0.4	-1.2
Loud music exposure frequency	1.9	2.1	4.2	1.7	-1.0	2.1	1.7	-1.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.1	-0.6	0.2	1.5	-0.4	0.6	0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.0	-0.7	-1.4	-0.9	1.2	-1.1	-1.1
Blood clot in the leg (DVT)	2.6	3.3	7.6	-1.3	1.6	2.8	1.6	-0.8	2.2
Medication: Paracetamol	0.6	1.0	1.9	-1.0	0.2	-0.9	-0.9	-1.4	-1.2
Headache pain in last month	1.4	2.3	5.5	2.3	-1.4	-0.5	1.6	-1.7	-1.0
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	6.0	0.4	0.6	-0.3	-1.4	2.4	0.6
Glaucoma (self-reported)	1.1	1.3	4.3	-0.1	-0.1	2.1	1.4	-1.0	0.5
Gout (self-reported)	0.4	0.6	1.4	0.1	1.2	-0.6	-0.6	-1.0	0.3
Hypothyroidism/myxoedema (self-reported)	1.9	3.6	10.5	0.5	-1.3	3.2	2.5	-1.6	0.7
Medication: Amlodipine	0.1	0.2	1.0	0.3	-0.1	1.0	-0.2	0.1	0.1
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.2	-0.7	1.1	0.4	-0.7	-1.0	0.3
Birth weight	0.7	1.6	4.0	-1.0	0.8	-2.0	-1.8	0.4	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	0.6	-0.6	-0.6	-0.2	-0.6	-1.1
High blood pressure (siblings)	0.4	0.6	1.9	1.0	-1.4	-0.4	0.4	0.1	-0.8
Forced vital capacity (FVC), Best measure	0.1	0.3	1.5	1.2	-0.4	-0.3	0.4	-0.1	-0.1
Body fat percentage	0.8	3.0	10.4	-3.2	2.1	-0.2	-1.0	-1.5	0.1
Leg fat percentage (right)	0.9	3.4	10.1	-3.2	2.7	0.5	-0.5	-0.8	1.3
Arm fat-free mass (right)	0.8	4.0	11.9	-3.5	2.2	-1.7	-1.7	0.8	0.7
Exposure to tobacco smoke outside home	2.2	3.0	6.3	-0.1	-1.7	2.5	1.8	-1.9	-1.2
Comparative body size at age 10	0.2	0.6	2.4	0.0	0.6	0.4	-0.5	1.6	0.8
Number of full brothers	2.1	2.6	8.2	0.9	0.5	2.9	1.7	-0.9	1.7
Worry too long after embarrassment	2.7	4.5	9.4	-0.4	-2.7	-0.4	2.0	-3.1	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	6.8	0.2	1.2	1.3	2.6	-1.3	2.1
Wheeze or whistling in the chest in last year	0.6	1.0	3.5	-0.2	1.9	-0.8	-0.6	-1.2	0.6
Number of children fathered	0.3	0.4	1.2	0.8	-0.2	0.3	1.1	-0.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.8	0.9	0.6	0.9	-0.2	1.3	1.1
Age at first live birth	3.2	5.6	15.6	1.4	-0.4	3.9	3.4	-1.2	1.8
Pulse wave peak to peak time	1.3	1.5	3.5	0.1	0.9	1.6	0.4	1.5	1.9
Health satisfaction	0.4	0.5	1.2	0.5	-0.1	-1.1	-1.0	0.4	-0.5
Shortness of breath walking on level ground	2.0	2.3	5.2	-0.3	-1.6	-0.9	0.6	-2.2	-2.3
Qualifications: College or University degree	1.0	3.1	9.1	0.4	-0.4	3.0	-0.0	2.6	1.6
Eye problems/disorders: None of the above	0.6	0.7	1.8	0.7	0.0	-1.4	-0.1	-1.2	-0.8
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.0	-1.0	1.4	-1.3	-0.6	-0.6	0.1
Emphysema/chronic bronchitis	1.1	1.3	4.4	0.4	-2.1	1.1	0.9	0.3	-0.8
Medication for pain relief, constipation, heartburn	0.9	1.5	6.4	1.0	-0.4	-0.7	-0.3	2.5	0.9
Neck or shoulder pain in last month	0.7	1.0	5.0	0.5	0.4	-2.2	-0.5	-0.5	-0.5
Medication: Blood pressure	1.1	1.9	6.0	-0.9	-1.0	-0.2	1.3	-2.5	-1.4
Angina (self-reported)	2.2	2.9	4.7	-1.4	0.7	2.1	2.2	-1.7	1.5
Migraine (self-reported)	1.4	1.7	3.4	1.8	-1.8	-0.7	0.5	1.1	-1.3
Medication: Ibuprofen	0.4	0.5	2.0	-0.8	-0.3	-0.1	0.4	-1.4	-0.6
Medication: Allopurinol	0.7	0.9	4.8	0.1	0.3	0.4	0.7	-2.2	-0.1
Medication: Omeprazole	2.2	2.6	4.3	-0.8	1.2	1.5	2.0	-2.1	1.8
Medication: Seretide 50 evohaler	0.4	0.4	0.8	-0.6	-0.0	-0.9	-0.9	0.5	-0.6
Mean time to correctly identify matches	0.5	1.0	2.7	-1.6	0.3	0.5	-0.8	1.5	0.4
Heart disease (mother)	0.7	0.8	2.4	0.2	0.5	0.4	1.3	-0.5	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	4.2	1.0	-1.4	-1.5	0.3	-1.9	-2.0
Whole body fat mass	0.9	3.6	13.1	-3.6	2.2	-0.7	-1.2	-1.1	0.2
Leg fat mass (right)	1.0	3.8	13.7	-3.7	2.6	-0.1	-0.9	-0.9	0.9
Arm predicted mass (right)	0.9	4.5	11.6	-3.4	2.4	-1.8	-2.0	1.3	0.8
Pulse rate, automated reading	0.7	2.1	6.3	0.8	0.6	2.5	1.6	-0.8	1.5
Alcohol intake frequency.	0.5	1.2	3.2	0.4	1.7	0.1	-0.3	0.9	1.8
Comparative height size at age 10	0.8	4.7	9.1	-3.0	2.7	1.9	-1.1	1.3	2.2
Number of full sisters	0.9	1.1	3.3	-0.5	1.4	-0.8	-1.8	0.8	0.3
Suffer from ‘nerves’	0.4	0.7	2.9	0.5	-0.5	-0.1	0.6	-1.7	-0.6
Overall health rating	0.3	0.6	2.0	1.0	0.0	0.4	0.4	-1.4	-0.0
Chest pain or discomfort	4.3	6.1	13.9	0.5	-2.0	2.3	3.7	-3.5	-0.7
Had major operations	2.9	3.4	6.7	0.8	-1.9	-1.2	1.5	-2.6	-2.4
Age at last live birth	2.4	3.5	8.6	1.3	-1.1	2.9	2.8	-0.8	1.0
Family relationship satisfaction	0.1	0.1	0.4	0.3	-0.3	0.4	0.2	-0.6	-0.1
Leg pain on walking	0.3	0.3	1.1	-1.1	0.6	-0.5	0.0	-0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	5.2	-1.2	-1.2	-0.4	-0.1	-1.4	-2.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.2	-0.0	-1.1	0.6	0.6	-1.1	-1.1
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	9.6	0.5	0.0	-0.1	-1.4	3.1	0.5
Medication: Aspirin	0.8	1.1	3.3	-0.3	0.2	1.8	1.2	-1.2	0.2
Supplements: Vitamin C	1.6	1.9	7.2	-0.5	-0.6	-0.7	1.0	-2.7	-1.4
Knee pain experienced in last month	1.1	1.7	4.3	-1.7	2.1	-0.4	-1.0	-0.7	1.2
Hypertension (Self-reported)	0.5	1.3	6.6	0.2	-0.2	-0.2	0.8	-2.6	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.2	-0.1	-1.5	-1.0	-0.1	-0.1	-1.4
Illnesses of father: Heart disease	0.7	0.9	3.1	1.4	-0.4	1.7	0.6	0.0	0.3
Illnesses of siblings: Diabetes	0.8	1.0	3.0	-0.0	-0.2	1.4	0.9	-1.7	0.0
Smoking status: Previous	0.5	0.8	1.6	-0.7	-0.8	1.1	1.2	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.4	-1.5	1.5	-0.1	-0.6	-1.0	0.3
Whole body fat-free mass	0.8	4.3	12.0	-3.5	2.4	-1.5	-2.0	1.1	0.8
Leg fat-free mass (right)	0.7	3.7	9.4	-3.1	2.1	-1.9	-2.1	0.3	0.2
Arm fat percentage (left)	0.7	2.9	10.5	-3.2	1.9	-0.5	-1.1	-1.4	0.0
Average weekly red wine intake	0.2	0.3	0.7	0.9	0.0	-0.7	-0.6	0.4	-0.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	0.6	0.4	-0.4	-0.8	-0.0	-0.1
Mood swings	1.1	1.9	5.4	-1.2	1.7	-1.3	-2.3	0.6	0.1
Loneliness, isolation	0.5	0.7	3.2	-1.8	0.8	-0.1	-0.7	-0.1	0.2
Long-standing illness, disability or infirmity	0.8	1.2	2.6	-0.2	1.0	1.6	0.4	-1.4	1.1
Ever had bowel cancer screening	0.9	1.1	2.7	-0.9	0.1	-1.4	-0.2	-1.7	-1.0
Diabetes diagnosed by doctor	0.7	1.1	2.8	-1.2	0.9	1.7	0.5	-0.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.9	-0.2	0.8	-0.8	-0.4	-1.4	-0.4
Friendships satisfaction	0.1	0.2	0.6	-0.0	-0.0	0.0	0.8	0.0	0.7
Qualifications: nursing, teaching	0.6	1.0	3.6	-0.1	-1.2	1.9	0.8	-0.1	-0.1
Commuting to job workplace: Walk	1.9	2.1	5.1	-0.7	1.7	-0.6	-2.3	1.8	0.7
Eye problems/disorders: Cataract	1.7	2.0	5.8	-2.4	0.2	-0.3	-2.0	1.3	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.3	0.4	-0.6	-0.3	0.3	1.1	-0.1
Medication for cholesterol	0.4	0.6	1.9	-0.2	-0.5	1.1	1.4	-0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	1.1	0.8	0.8	-0.1	-0.5	0.6
Back pain experienced in last month	2.0	3.0	6.2	-0.6	2.5	-1.4	-2.4	1.3	1.5
Mineral and other dietary supplements	0.8	1.0	2.0	1.4	0.7	-0.4	0.7	1.1	1.4
Breast cancer (self-reported)	0.4	0.5	0.9	0.4	-0.9	-0.3	-0.7	0.7	-0.9
Asthma (self-reported)	1.1	2.1	7.7	-0.6	2.8	-0.0	-1.6	-1.2	0.9
Osteoporosis (self-reported)	1.1	1.3	3.3	-0.0	-0.9	1.2	1.8	-1.5	-0.4
Osteoarthritis (self-reported)	1.5	2.0	4.2	-1.8	0.2	-0.7	-2.0	1.9	-0.7
Medication: Aspirin	0.8	1.0	4.0	-0.3	0.4	2.0	1.0	-0.7	0.5
Medication: Gliclazide	0.9	1.0	2.5	-1.1	1.6	-0.5	-1.4	-0.5	-0.1
Illnesses of father: None of the above (group 1)	0.3	0.3	1.0	-0.1	0.9	-0.2	0.3	0.3	1.0
Smoking status: Current	1.5	2.5	6.3	-1.2	1.9	-1.8	-2.5	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	9.0	1.4	-3.0	-0.2	1.5	-0.3	-1.9
Whole body water mass	0.7	4.2	11.4	-3.4	2.5	-1.5	-1.9	1.1	0.9
Leg predicted mass (right)	0.7	3.6	9.2	-3.0	2.0	-2.0	-2.1	0.3	0.1
Arm fat mass (left)	0.8	3.5	13.0	-3.6	2.2	-0.6	-1.4	-0.8	0.4
Number of self-reported non-cancer illnesses	0.5	0.9	2.1	0.5	0.4	1.4	0.7	-1.4	0.6
Average weekly champagne plus white wine intake	0.8	1.1	2.6	1.0	0.4	-1.6	-1.2	1.1	0.1
Miserableness	1.0	1.8	8.0	0.1	0.1	-1.0	0.4	-2.8	-1.2
Guilty feelings	1.7	2.6	6.8	-1.6	-0.7	-1.0	-0.1	-2.6	-2.1
Wears glasses or contact lenses	2.4	2.7	7.4	1.1	-2.2	1.3	2.7	-1.0	-0.4
Ever taken oral contraceptive pill	2.2	2.4	4.8	0.8	-1.0	-1.8	-0.6	-2.2	-2.2
Hearing aid user	2.0	2.3	5.9	-0.9	2.4	-1.0	-0.9	1.1	2.1
Mother’s age at death	0.3	0.4	1.9	1.4	-0.6	-0.3	0.2	-0.1	0.1
Financial situation satisfaction	2.0	2.5	5.5	0.5	-2.0	-0.5	0.8	-2.0	-2.4
Tinnitus: Yes, now most or all of the time	2.3	2.6	11.4	3.4	-0.8	1.3	1.4	-0.1	0.6
Commuting to job workplace: Public transport	0.7	0.9	1.9	1.4	-0.4	0.3	1.4	-1.1	0.1
Eye problems/disorders: Glaucoma	1.3	1.6	3.7	-0.5	0.9	1.7	1.4	0.1	1.9
Medication: Blood pressure	0.3	0.6	1.7	0.4	1.3	0.5	-0.7	0.1	1.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.0	-0.5	0.9	1.7	0.3	0.0	1.3
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.5	-2.1	-0.2	-0.7	-1.5	-0.8	-1.6
High cholesterol (Self-reported)	0.8	1.4	2.9	1.6	-0.2	0.8	1.4	-1.7	0.4
Medication: Bendroflumethiazide	1.1	1.6	4.1	-0.8	2.0	-1.6	-1.0	0.1	1.2
Medication: Paracetamol	0.6	0.9	1.8	-0.3	0.0	-1.0	-1.0	-1.2	-1.4
Medication: Lisinopril	0.1	0.2	0.4	0.6	-0.2	0.5	0.2	-0.4	0.3
Medication: Atorvastatin	1.0	1.2	2.8	0.1	1.7	0.8	0.6	-1.2	1.4
Illnesses of father: High blood pressure	0.2	0.2	0.5	0.3	-0.4	-0.7	-0.3	-0.0	-0.6
Alcohol drinker status: Never	1.7	2.1	4.4	1.4	-2.1	1.6	1.8	0.4	-0.5
Ever smoked	0.2	0.3	1.2	-1.1	0.3	0.4	-0.4	0.5	0.2
Basal metabolic rate	0.8	4.7	13.6	-3.7	2.6	-1.5	-2.0	0.7	0.8
Leg fat percentage (left)	1.0	3.6	12.1	-3.5	2.6	-0.1	-0.8	-1.0	1.0
Arm fat-free mass (left)	0.8	4.0	10.9	-3.3	2.6	-1.2	-1.5	0.9	1.3
Number of operations (self-reported)	1.7	2.5	5.3	2.3	-1.2	-2.1	0.5	-0.4	-1.8
Average weekly beer plus cider intake	1.4	2.0	4.0	-2.0	0.6	-0.6	-1.4	-1.9	-1.3
Irritability	0.3	0.6	1.2	-1.1	1.1	0.7	-0.0	-0.4	0.7
Risk taking	2.2	3.2	8.5	-0.9	2.9	-0.0	-2.4	1.0	1.8
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.5	-0.4	-0.6	-0.7	0.6	-2.1	-1.3
Fractured/broken bones in last 5 years	1.5	1.9	5.7	0.0	-0.9	1.1	1.9	-2.4	-0.4
Age started oral contraceptive pill	1.3	1.6	3.8	2.0	-1.8	0.5	0.1	1.4	-0.7
Diastolic blood pressure, automated reading	0.2	0.5	1.9	1.4	-0.4	-0.4	0.8	-0.3	-0.2
Ever depressed for a whole week	2.1	2.6	8.8	-0.0	-1.2	3.0	2.1	-0.8	0.2
Unable to work because of sickness or disability	1.0	1.3	2.6	-0.9	1.6	1.4	0.2	-1.1	1.1
Commuting to job workplace: Cycle	1.0	1.2	4.0	0.2	1.4	0.4	1.0	-0.5	2.0
Myopia	2.4	3.5	9.4	2.0	-3.1	-0.2	0.9	-0.2	-2.6
Vascular/heart problems diagnosed by doctor	0.9	2.4	8.2	0.2	0.0	-1.5	-2.1	2.9	-0.1
Cholesterol lowering medication	0.2	0.2	1.0	-0.2	0.1	1.0	-0.5	0.3	-0.0
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	7.6	-0.2	1.6	1.2	1.7	-2.8	1.6
Pain experienced in last month	1.0	1.7	6.8	-1.3	-0.5	2.6	0.9	0.7	0.5
Supplements: Calcium	1.1	1.2	4.1	2.0	-0.2	1.4	0.8	-0.2	0.5
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	-0.8	1.1	0.6	-0.5	-0.1	0.7
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.1	-1.6	0.2	2.0	0.9	-0.8	0.4
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	7.6	-1.1	1.4	2.8	1.8	-1.1	2.1
Heart disease (siblings)	0.7	0.8	3.6	-1.9	0.1	-0.3	0.1	-1.1	-0.3
Alcohol drinker status: Previous	2.6	2.9	8.1	1.1	2.9	0.0	0.2	-0.3	2.8
Pack years of smoking	0.3	0.4	0.8	-0.7	-0.3	-0.0	0.6	-0.9	-0.7
Impedance of whole body	0.4	1.8	6.1	1.5	0.5	2.5	0.9	-0.7	1.1
Leg fat mass (left)	1.1	4.2	15.8	-4.0	2.6	-0.3	-0.9	-1.1	0.8
Arm predicted mass (left)	0.8	4.0	11.6	-3.4	2.5	-1.1	-1.5	0.9	1.2