Hub : Genes

MRPL9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.2440	0.0790	6.9e-05	0.020	NA	0.117	NA	0.029	3.6e-02	NA	3.4e-06	NA	1.6e-02
2	GTEx	Heart Atrial Appendage	0.1330	0.0570	6.7e-03	-0.002	NA	0.000	NA	0.016	4.3e-01	NA	3.1e-01	NA	6.4e-02
3	NTR	Blood	0.0229	0.0084	3.7e-05	0.023	0.015	0.014	0.015	0.024	3.4e-08	7.8e-06	1.7e-05	8.6e-06	2.3e-08
4	ROSMAP	Brain Pre-frontal Cortex	0.0325	0.0218	4.0e-02	0.006	0.002	0.027	0.004	0.020	5.5e-02	1.9e-01	1.8e-04	8.3e-02	1.3e-03
5	TCGA	Thyroid Carcinoma	0.0490	0.0320	3.9e-04	0.048	0.038	0.036	NA	0.042	1.8e-05	1.2e-04	1.8e-04	NA	5.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	2.2	3.5	7.4	1.8	-1.9	2.7	-1.1	1.4
Bipolar Disorder or Schizophrenia	1.4	3.4	5.0	1.9	-1.9	2.2	-1.7	1.3
Depressed Affect (Nagel 2018)	0.4	0.8	2.4	-0.1	1.6	-0.9	0.6	-0.8
Depression (Nagel 2018)	1.5	2.2	5.4	2.3	1.0	1.3	-0.5	1.6
Intelligence (Savage-Jansen 2018)	0.8	2.3	6.1	2.5	0.7	0.9	-1.1	1.8
Neuroticism (Nagel 2018)	0.9	2.2	5.7	1.0	2.4	-1.2	1.5	0.6
Schizophrenia (2018)	0.4	0.8	1.6	1.0	-0.9	0.7	-1.2	0.5
Schizophrenia vs Biploar Disorder	1.4	1.8	6.8	0.4	2.6	-1.2	-0.4	0.6
Worry (Nagel 2018)	1.1	2.3	3.8	1.3	1.9	-0.2	1.6	1.9
Alzheimer’s Disease (in mother)	0.5	0.6	2.0	0.6	1.4	-0.6	-0.5	0.3
Alzheimer’s Disease (in father)	0.3	0.4	0.7	0.7	-0.8	0.0	0.8	0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.3	0.3	-0.8	-0.2	-0.7
Crohns Disease (2017)	2.0	4.3	13.2	0.9	2.2	-3.6	-1.5	-0.7
Irritable Bowel Disease (IBD)	2.5	6.0	16.0	1.6	4.0	-3.2	-0.9	0.7
Ulcerative Colitis (UC)	2.4	4.6	14.0	2.3	3.7	-1.4	0.0	1.3
Major Depression (MDD)	1.1	1.3	3.4	1.2	1.2	0.5	-0.3	1.8
Reaction Time	1.0	1.9	5.6	-1.8	-2.4	-0.1	-0.2	-0.9
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.9	1.7	0.9	0.7	0.0	2.2
Breast Cancer	0.4	0.9	3.0	-0.6	-1.1	1.7	0.3	0.1
Ovarian Cancer	1.4	1.9	4.0	-1.2	-2.0	-0.9	1.3	-1.2
Prostate Cancer	2.1	2.9	7.9	-1.1	-2.8	1.2	1.3	-1.5
Age at First Birth	3.0	4.3	9.9	1.4	0.1	3.1	-0.7	3.0
Bipolar Disorder (2011)	2.5	2.4	7.5	0.0	-2.7	2.1	0.0	0.2
Body Mass Index (BMI) (2010)	0.4	0.5	2.0	-1.4	-0.3	0.3	-0.4	-0.1
Coronary Artery Disease (CAD)	1.9	2.2	4.8	1.7	1.2	-2.2	-0.8	1.2
Crohns Disease (2012)	1.1	1.8	5.3	0.9	1.6	-2.3	0.1	-0.8
Mean Putamen Volume	1.3	1.5	4.5	-0.5	-1.0	0.5	2.1	1.3
Fasting Glucose	0.6	0.7	1.8	-0.4	-1.2	0.1	0.5	-1.3
HbA1C	0.6	0.7	1.8	-0.2	-1.3	0.7	-0.1	-0.9
HDL Cholesterol	0.6	1.0	2.6	0.9	0.2	1.6	-1.0	0.6
LDL Cholesterol	0.2	0.3	0.6	-0.2	0.4	-0.3	-0.7	0.8
Lupus	1.7	2.6	4.2	1.7	1.9	1.2	-0.7	2.1
Neuroticism (2016)	2.3	3.3	7.0	1.2	2.5	-0.5	-1.2	2.6
Primary Biliary Cirrhosis	1.2	1.7	4.2	0.1	-1.1	2.0	-0.4	1.7
Rheumatoid Arthritis	0.2	0.3	0.9	0.7	-0.3	0.2	-0.2	-0.9
Schizophrenia (2014)	0.3	0.7	1.0	0.7	-0.9	0.9	-0.5	1.0
Triglycerides	1.0	1.7	3.8	-2.0	-1.1	0.2	-1.2	-1.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.9	0.2	0.4	-2.0	-1.6	-0.7
Ulcerative Colitis	1.6	2.3	6.3	1.2	2.5	-0.7	-0.3	1.8
Blood Eosinophil Count	0.2	1.7	3.8	-0.2	1.5	1.2	1.9	0.8
Blood Platelet Count	0.4	5.1	10.0	-3.2	-2.3	-1.9	-0.0	-2.6
Blood Red Count	1.2	11.6	28.3	3.0	1.8	2.2	3.5	5.3
Blood White Count	0.3	1.9	4.8	0.1	2.2	-1.7	0.6	1.2
Heel T-Score	0.3	2.4	8.4	1.7	0.6	-0.7	-0.2	2.9
BMI	0.7	4.1	9.2	-0.4	2.5	-3.0	-1.8	-1.2
Height	0.4	8.5	21.5	-4.6	-1.8	-2.3	0.9	-3.4
Waist Hip Ratio (WHR)	0.5	2.1	3.8	0.6	2.0	-1.9	1.6	0.4
Systolic Blood Pressure	0.3	1.6	4.0	-0.4	-1.4	0.9	1.0	2.0
Smoking Status	0.8	2.0	4.8	-0.7	0.9	-1.9	0.0	-2.2
Allergy or Eczema	2.3	6.1	17.2	1.9	4.2	-2.8	1.1	0.5
Cardiovascular Disease	0.4	1.3	3.2	0.4	1.8	-0.5	1.3	1.1
Hypothyroidism (self reported)	3.0	7.0	21.0	4.6	1.7	1.1	1.8	2.5
Respiratory disease	4.3	9.6	18.6	-1.3	2.4	-4.0	4.3	-2.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.4	0.7	-0.4	-0.2	0.0
Lung FEV1/FVC ratio	0.0	0.2	0.4	0.3	-0.3	-0.4	0.3	0.6
Lung FVC	1.2	5.9	17.3	0.8	-1.2	4.2	-2.8	1.5
Neuroticism	1.0	2.4	6.0	1.8	2.4	-0.7	0.6	1.4
Chronotype (morning person)	2.4	5.6	12.3	-2.4	-0.7	-3.5	-0.1	-3.1
Hair Pigment	0.0	1.4	3.7	-0.9	-1.1	-0.1	1.2	-1.9
Tanning	0.1	1.7	4.5	-0.1	-0.5	-1.4	2.1	-1.4
Hand grip strength (left)	0.6	1.5	4.2	-1.3	-0.6	-1.1	2.0	-0.6
Number of treatments/medications taken	1.8	3.2	7.3	1.3	2.3	-2.7	1.3	0.1
Average weekly spirits intake	1.5	1.8	4.1	0.5	1.7	-1.4	-2.0	-0.5
Sensitivity / hurt feelings	1.0	1.7	4.0	0.7	2.0	-1.8	0.6	0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.4	0.9	1.5	0.1	0.0	0.6
Hearing difficulty/problems: Yes	0.7	1.1	2.6	0.2	1.2	-1.6	-0.1	-1.1
Relative age of first facial hair	0.2	0.3	1.1	0.2	-0.1	0.8	1.0	-0.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.7	0.9	1.5	-1.6	0.2	-0.8
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.8	-0.2	1.0	-1.7	0.9	-1.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.6	-0.6	-0.2	0.2	0.5
Systolic blood pressure, automated reading	0.5	1.5	4.2	-0.9	-1.3	0.9	0.1	2.0
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	2.8	1.3	1.7	-1.6	1.2	1.3
Angina	2.0	2.7	7.8	1.0	2.8	-1.2	-1.2	1.3
Medication for hormone replacement therapy	0.4	0.4	1.6	-0.4	-0.4	-0.5	-0.2	-1.3
Vitamin and mineral supplements	0.4	0.5	1.5	-0.8	-1.2	-0.3	-0.6	-0.4
Supplements: Zinc	0.6	0.6	1.7	-0.6	1.3	-1.0	0.2	-0.3
Medication: Co-codamol	1.6	1.8	4.5	-1.8	-0.2	-2.1	-0.8	-0.8
Medication: Metformin	1.0	1.4	6.1	-0.5	0.6	-2.5	0.3	-0.1
Diabetes (father)	0.5	0.7	1.6	1.3	0.8	-0.4	-0.9	0.0
Diabetes (mother)	0.5	0.6	1.1	-0.1	-0.9	0.6	-0.7	1.1
Severe depression (siblings)	1.6	1.8	6.5	2.6	0.2	0.1	0.3	1.5
Pack years adult smoking proportion	1.6	2.5	6.8	-0.8	1.7	-1.4	-2.6	-0.4
Impedance of leg (right)	0.2	1.1	2.0	-0.7	0.4	-1.2	1.4	1.1
Leg fat-free mass (left)	0.8	4.1	6.6	-2.3	0.3	-2.5	-1.7	-2.6
Trunk fat percentage	1.9	7.6	21.9	-1.1	3.0	-4.7	-1.9	-1.5
Hand grip strength (right)	0.2	0.7	1.5	-1.2	-0.6	-0.9	0.5	-0.6
Townsend deprivation index at recruitment	2.4	3.3	9.5	-0.7	1.1	-3.1	0.8	-2.2
Current tobacco smoking	2.1	3.4	6.6	-1.2	1.4	-2.6	-1.4	-2.3
Average weekly fortified wine intake	0.2	0.3	0.6	0.8	0.6	-0.1	0.7	-0.2
Maternal smoking around birth	1.6	2.4	6.5	-0.1	2.1	-2.5	0.0	-0.9
Fed-up feelings	0.8	1.4	3.4	-0.2	1.8	-1.7	0.6	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.9	0.9	2.0	-1.2	1.2	0.0
Relative age voice broke	0.6	0.9	3.3	-0.2	-0.5	0.9	1.8	-0.2
Taking other prescription medications	2.5	3.8	7.8	1.1	2.8	-2.6	1.6	0.8
Age when periods started (menarche)	0.3	0.7	1.4	-0.0	1.2	-1.1	-1.1	0.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	0.2	1.3	-0.8	1.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	0.9	0.8	-0.9	0.4	0.7	0.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.6	0.2	1.6	-1.2	-0.3	1.1
Qualifications: CSEs or equivalent	2.6	3.4	7.0	-1.4	1.4	-2.6	0.9	-2.3
Serious illness, injury or assault to yourself	2.8	3.4	9.4	3.1	2.1	-1.0	0.4	1.4
High blood pressure	0.5	1.5	3.6	-0.3	1.6	-1.9	0.0	1.0
Hayfever, allergic rhinitis or eczema	1.7	3.8	10.2	1.6	3.2	-2.1	1.1	0.7
Multivitamins +/- minerals	0.5	0.6	1.5	1.2	0.6	0.7	0.6	0.6
Stomach or abdominal pain in last month	1.3	1.6	3.2	1.6	1.3	0.2	0.5	1.8
Supplements: Glucosamine	0.1	0.1	0.6	0.3	0.1	0.2	0.7	-0.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	2.5	0.0	0.6	0.1	1.6	-1.0
Medication: Atenolol	0.6	0.8	1.9	-1.1	-0.8	0.1	-0.5	1.4
Medication: Levothyroxine sodium	0.7	1.1	3.1	1.5	-0.4	0.2	1.8	-0.1
Sitting height	0.4	3.0	7.3	-2.7	-1.4	-1.3	-0.1	-1.9
Chronic bronchitis/emphysema (father)	1.2	1.5	4.2	-0.9	1.1	-2.0	0.0	-1.0
High blood pressure (mother)	0.5	0.7	2.9	0.4	0.3	-0.6	0.4	1.7
Body mass index (BMI)	0.8	3.4	7.7	-0.7	1.7	-2.8	-1.4	-1.9
Impedance of leg (left)	0.2	1.0	1.8	-0.5	0.5	-1.4	1.2	1.0
Leg predicted mass (left)	0.8	4.1	6.6	-2.3	0.3	-2.5	-1.7	-2.6
Trunk fat mass	1.7	7.2	20.6	-1.6	2.6	-4.5	-1.7	-1.9
Waist circumference	1.2	4.5	13.4	-0.5	2.3	-3.7	-1.0	-1.6
Number of incorrect matches in round	0.5	0.8	1.9	0.1	-0.9	1.1	1.4	-0.3
Past tobacco smoking	0.3	0.5	1.5	-1.2	-0.3	0.4	-0.9	0.1
Alcohol usually taken with meals	4.1	6.6	13.1	3.2	-0.4	3.6	-1.4	2.8
Nervous feelings	1.1	2.1	5.3	1.1	0.7	0.9	1.7	2.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	0.0	0.5	-0.4	-0.3	0.3
Hearing difficulty/problems with background noise	0.8	1.3	3.0	1.7	0.9	-0.3	-1.1	1.3
Hair/balding pattern: Pattern 2	0.7	0.9	3.0	-0.1	-0.3	0.4	1.7	-1.1
Had menopause	0.4	0.4	2.1	0.1	-1.4	-0.0	-0.3	0.0
Had other major operations	0.6	0.7	2.7	-0.6	-1.7	0.6	0.1	-0.5
Forced vital capacity (FVC)	0.4	1.6	3.6	-1.9	-0.8	1.5	-1.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	0.7	-0.9	0.1	0.9	0.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.0	1.7	0.1	0.9	-0.5	1.7
Qualifications: None of the above	0.4	0.9	1.8	-1.3	0.6	-1.3	0.3	-0.7
Financial difficulties in last 2 years	1.6	2.2	4.2	0.0	2.0	-1.8	1.8	-0.3
Mouth/teeth dental problems	1.2	1.9	5.6	2.4	1.5	1.1	0.0	0.7
Heart attack	0.1	0.1	0.4	0.4	0.6	-0.2	-0.0	0.0
Allergy	1.5	3.5	8.8	-1.6	-3.0	2.2	-1.2	-0.1
Pain all over the body in last month	0.6	0.7	1.0	-0.1	1.0	-0.6	1.0	1.0
Diabetes (self-reported)	0.4	0.6	1.9	0.5	1.0	-1.4	-0.0	0.2
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	7.7	1.6	2.8	-0.8	-0.3	1.5
Medication: Ramipril	3.6	4.6	13.5	-1.1	2.7	-3.7	-0.1	-1.0
Medication: Simvastatin	0.8	1.2	4.4	0.1	0.3	-1.1	2.1	0.3
Fluid intelligence score	1.9	4.0	10.5	1.7	0.8	1.8	-1.7	3.2
Illnesses of siblings	0.4	0.5	1.8	0.6	0.4	-0.0	-1.4	-0.7
Neuroticism score	1.4	3.0	7.5	0.7	2.7	-1.9	1.8	0.3
Weight	1.1	5.6	12.8	-2.3	1.0	-3.6	-1.3	-2.6
Impedance of arm (right)	0.2	1.1	3.4	0.1	1.0	-1.8	-0.7	0.7
Arm fat percentage (right)	1.7	6.6	17.8	-0.5	2.8	-4.2	-1.9	-1.8
Trunk fat-free mass	0.6	3.2	6.7	-2.6	-1.1	-1.4	-0.1	-2.5
Hip circumference	1.0	4.1	9.9	-0.9	1.4	-3.1	-2.1	-1.9
Time employed in main current job	1.2	1.4	4.7	0.7	0.7	-0.1	-2.2	1.1
Alcohol intake versus 10 years previously	2.1	3.1	6.7	-1.8	-0.4	-2.1	1.1	-2.6
Father’s age at death	0.5	0.6	1.8	0.2	0.3	1.4	-1.0	0.1
Worrier / anxious feelings	1.7	3.2	6.1	1.3	2.5	0.5	1.4	2.5
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	8.5	1.7	2.9	-0.1	1.8	-0.2
Falls in the last year	0.6	0.8	2.2	0.9	1.5	-0.8	-0.3	0.3
Hair/balding pattern: Pattern 3	0.6	0.9	3.8	-0.1	-1.9	0.8	0.3	-0.4
Number of live births	0.8	1.1	2.2	-0.8	-1.4	1.5	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.1	-1.1	-0.2	1.4	-1.2	0.8
Pulse rate	0.7	1.2	2.5	1.0	1.6	-1.1	-0.9	0.7
Happiness	1.1	1.3	3.1	0.8	1.8	0.7	-0.7	1.3
Noisy workplace	2.2	2.7	5.7	-2.4	-0.2	-2.1	0.5	-1.8
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.2	1.5	-0.9	1.3	-0.8	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.9	-0.4	-0.0	-1.4	0.5	-0.8
Mouth/teeth dental problems: Dentures	2.1	3.5	11.1	-3.3	-1.8	-0.6	-0.2	-1.6
Asthma	3.3	6.5	13.2	-0.9	1.3	-3.6	3.6	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.0	1.3	1.0	0.1	1.4	0.2
Medication: Cholesterol lowering	1.1	1.8	4.3	0.8	2.1	-1.9	0.5	0.5
Depression (self-reported)	0.9	1.1	3.7	0.3	1.9	-1.0	-0.6	0.6
Medication: Lansoprazole	1.5	1.7	3.5	-0.6	-1.8	1.0	1.9	-0.9
Prospective memory result	1.7	2.0	3.9	-2.0	-1.6	0.1	-1.0	-1.6
Lung cancer (father)	1.4	1.7	3.3	-1.1	-0.7	-1.8	-0.9	-1.5
Illnesses of mother	2.0	2.5	7.1	-1.8	-1.1	-0.5	0.7	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.1	-1.0	0.2	1.3	-1.4	1.1
Pulse wave Arterial Stiffness index	0.4	0.4	1.1	0.3	0.3	0.5	0.8	-1.1
Impedance of arm (left)	0.2	1.1	3.1	-0.1	0.8	-1.8	-1.1	0.8
Arm fat mass (right)	1.3	5.4	14.8	-1.1	2.1	-3.8	-1.5	-2.0
Trunk predicted mass	0.6	3.4	7.0	-2.6	-1.1	-1.4	-0.0	-2.6
Standing height	0.4	3.9	11.3	-3.4	-1.2	-2.0	-0.1	-1.6
Length of working week for main job	2.4	2.7	4.8	-1.9	-0.5	-1.8	1.2	-2.2
Exposure to tobacco smoke at home	2.0	2.2	8.2	0.2	2.9	-1.5	-0.2	0.5
Breastfed as a baby	3.9	4.9	8.7	2.8	1.2	2.1	-1.4	2.9
Tense / ‘highly strung’	1.0	1.6	5.5	-0.1	1.2	-0.9	2.3	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.9	8.4	2.3	2.9	-0.4	0.8	2.2
Hair/balding pattern: Pattern 4	2.0	4.9	15.8	0.9	0.0	0.5	-4.0	2.7
Birth weight of first child	0.2	0.4	1.1	0.1	-0.7	1.0	-0.3	0.4
Peak expiratory flow (PEF)	0.5	1.2	2.1	1.4	0.9	0.9	-0.7	1.4
Pulse wave reflection index	0.6	0.7	3.0	-0.0	0.7	0.4	1.7	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.4	0.7	-0.2	-0.8	-0.3
Loud music exposure frequency	2.6	2.8	4.7	2.2	1.9	1.0	1.2	1.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	0.9	-0.9	0.5	-0.0	-0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	0.9	0.3	0.5	0.8	1.2
Blood clot in the leg (DVT)	1.4	1.8	4.5	1.5	2.1	-0.6	-1.0	0.9
Medication: Paracetamol	1.6	2.6	3.5	-1.8	1.9	-1.3	1.6	-1.4
Headache pain in last month	0.6	1.0	2.2	-0.3	1.4	0.9	0.1	1.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.6	-1.5	-1.9	1.1	-0.4	-0.7
Glaucoma (self-reported)	0.5	0.6	1.7	1.3	-0.2	0.2	0.9	0.7
Gout (self-reported)	0.5	0.7	1.6	-0.5	1.3	-0.9	-0.2	-0.9
Hypothyroidism/myxoedema (self-reported)	2.8	5.5	16.2	4.0	1.4	0.9	1.9	2.3
Medication: Amlodipine	0.3	0.4	1.0	0.2	-1.0	-0.7	-0.7	-0.3
Medication: Ventolin 100micrograms inhaler	2.1	2.6	6.1	1.5	1.8	-2.5	1.0	-0.8
Birth weight	0.9	1.9	5.2	-1.9	-0.1	-0.7	-0.4	-2.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.2	0.0	1.1	-0.8	-0.4	-0.1
High blood pressure (siblings)	1.8	2.6	7.0	-0.8	-2.2	0.5	2.6	0.7
Forced vital capacity (FVC), Best measure	0.3	1.1	2.1	-1.4	0.4	0.9	-1.4	0.7
Body fat percentage	2.0	7.8	22.9	-1.2	3.0	-4.8	-1.6	-1.8
Leg fat percentage (right)	1.7	6.1	18.8	-1.2	2.6	-4.3	-0.9	-1.5
Arm fat-free mass (right)	0.6	3.1	7.5	-2.7	-0.4	-1.6	-0.0	-2.3
Exposure to tobacco smoke outside home	1.6	2.1	3.9	2.0	2.0	-0.0	0.9	1.4
Comparative body size at age 10	0.2	0.5	1.9	-0.3	-1.4	-0.7	-0.1	-0.1
Number of full brothers	1.2	1.6	3.3	0.4	0.6	-1.6	1.2	1.8
Worry too long after embarrassment	1.9	3.2	5.9	2.4	2.2	-0.3	0.9	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	6.9	0.5	2.6	-2.0	-0.5	2.0
Wheeze or whistling in the chest in last year	2.0	3.6	9.7	-2.1	1.5	-3.1	0.7	-1.1
Number of children fathered	0.2	0.2	1.1	-0.2	0.1	-0.1	-0.3	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	0.1	-1.3	0.6	1.0	0.0
Age at first live birth	2.7	4.9	10.8	2.5	2.0	0.8	-1.6	3.3
Pulse wave peak to peak time	0.4	0.5	1.2	-0.3	-0.3	-0.5	-0.9	1.1
Health satisfaction	0.3	0.4	0.9	-0.1	-0.5	-0.2	0.8	-1.0
Shortness of breath walking on level ground	1.2	1.4	4.0	0.9	1.5	-0.2	2.0	-0.1
Qualifications: College or University degree	0.7	2.3	5.4	1.0	-2.1	2.3	-0.3	0.9
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.8	0.8	-0.5	-0.4	-0.4
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.8	-1.3	1.0	-2.0	1.2	-1.2
Emphysema/chronic bronchitis	1.6	1.8	4.2	0.9	-0.4	1.6	2.0	1.1
Medication for pain relief, constipation, heartburn	1.7	2.8	5.8	0.3	-2.3	2.4	-1.6	0.5
Neck or shoulder pain in last month	0.4	0.5	0.8	-0.8	0.5	-0.4	0.9	-0.9
Medication: Blood pressure	0.9	1.5	3.6	1.1	1.9	-1.4	-0.6	0.7
Angina (self-reported)	2.1	2.8	8.3	1.1	2.9	-1.0	-0.9	1.6
Migraine (self-reported)	1.2	1.4	3.3	-0.5	-1.3	1.8	0.6	1.2
Medication: Ibuprofen	0.5	0.6	1.4	1.2	0.9	-0.0	0.7	-0.1
Medication: Allopurinol	1.0	1.4	4.7	0.8	2.2	-1.1	-0.4	0.1
Medication: Omeprazole	3.8	4.5	9.0	2.4	3.0	-2.1	-1.2	1.4
Medication: Seretide 50 evohaler	0.3	0.3	0.9	-0.7	-0.0	-0.4	0.3	-1.0
Mean time to correctly identify matches	0.6	1.1	3.1	-1.4	-1.8	-0.1	-0.2	-0.4
Heart disease (mother)	0.5	0.6	1.4	0.8	1.0	-0.4	0.1	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	0.7	0.4	0.2	0.2	0.1
Whole body fat mass	1.7	7.0	19.6	-1.7	2.5	-4.4	-1.5	-2.0
Leg fat mass (right)	1.6	6.4	18.1	-1.6	2.5	-4.3	-1.3	-1.9
Arm predicted mass (right)	0.7	3.8	9.2	-3.0	-0.8	-1.6	-0.3	-2.6
Pulse rate, automated reading	0.4	1.2	2.1	0.1	1.4	-1.4	0.3	1.4
Alcohol intake frequency.	0.3	0.8	3.0	-1.7	0.3	-0.3	0.7	-0.5
Comparative height size at age 10	0.4	2.4	5.0	-2.2	-0.3	-2.2	-0.5	-1.3
Number of full sisters	0.9	1.1	3.6	-0.2	-0.2	-1.4	0.1	-1.9
Suffer from ‘nerves’	0.6	1.0	2.6	1.1	1.6	-0.7	0.0	0.8
Overall health rating	0.9	2.0	7.1	0.2	2.7	-1.6	0.5	0.4
Chest pain or discomfort	5.4	7.8	13.1	3.6	3.6	-0.2	-0.9	3.5
Had major operations	2.2	2.5	7.2	0.2	2.0	-0.1	2.7	1.2
Age at last live birth	2.7	4.0	7.7	2.4	1.3	1.8	-1.2	2.8
Family relationship satisfaction	0.8	0.9	3.5	0.6	0.4	0.8	-1.9	0.1
Leg pain on walking	0.8	1.0	2.9	-0.2	0.7	-1.2	1.7	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	0.7	1.2	-0.6	0.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	0.4	-0.0	-0.6	1.0	0.5
Illness, injury, bereavement, stress in last 2 years	3.1	3.8	8.6	-1.4	-2.9	2.2	-1.8	-0.8
Medication: Aspirin	1.1	1.5	3.2	0.8	1.8	-1.7	0.1	0.8
Supplements: Vitamin C	1.5	1.8	6.1	0.0	2.5	-1.5	0.1	0.6
Knee pain experienced in last month	1.3	1.9	3.4	0.4	1.8	-1.9	-0.6	-1.5
Hypertension (Self-reported)	0.6	1.6	4.0	-0.4	1.9	-2.0	-0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.1	1.2	-1.4	1.1	1.1	0.4
Illnesses of father: Heart disease	0.4	0.5	1.4	0.6	-0.5	0.2	-1.2	0.8
Illnesses of siblings: Diabetes	0.8	1.0	1.5	1.2	1.1	-1.2	0.8	0.7
Smoking status: Previous	0.7	1.0	2.9	1.7	0.7	0.3	0.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	6.2	-1.4	1.1	-2.5	1.9	-1.1
Whole body fat-free mass	0.6	3.3	6.4	-2.5	-0.5	-1.8	-0.7	-2.5
Leg fat-free mass (right)	0.7	3.9	6.7	-2.1	0.3	-2.3	-1.7	-2.6
Arm fat percentage (left)	1.8	7.1	19.1	-0.7	2.8	-4.4	-2.1	-1.8
Average weekly red wine intake	1.3	1.9	8.3	0.8	-0.7	0.2	-2.9	-0.0
Handedness (chirality/laterality): Left-handed	1.2	1.4	6.1	0.5	0.1	-0.5	2.5	-0.7
Mood swings	1.4	2.5	5.4	-1.3	0.8	-2.0	0.9	-2.3
Loneliness, isolation	0.9	1.2	2.6	-0.2	1.5	-1.6	0.4	-1.0
Long-standing illness, disability or infirmity	1.8	2.7	6.8	0.6	2.1	-2.6	1.4	-0.1
Ever had bowel cancer screening	0.6	0.7	1.6	-0.7	0.8	-1.3	-0.3	-0.8
Diabetes diagnosed by doctor	0.4	0.7	1.7	0.5	0.9	-1.3	-0.7	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.8	5.4	-0.3	1.0	-2.3	-1.2	-0.9
Friendships satisfaction	0.5	0.6	1.2	-0.4	0.1	0.8	-1.1	0.9
Qualifications: nursing, teaching	2.1	3.3	6.3	2.5	0.3	2.0	-2.3	0.8
Commuting to job workplace: Walk	3.0	3.3	5.4	-2.3	-1.5	-2.0	1.1	-1.8
Eye problems/disorders: Cataract	1.0	1.2	3.5	-0.6	-0.8	-0.2	1.2	-1.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.6	-0.5	0.4	-0.8	0.4
Medication for cholesterol	0.6	1.0	2.1	0.9	0.2	1.4	-0.0	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-1.1	0.2	-1.1	-0.4	-0.0
Back pain experienced in last month	2.1	3.1	6.5	-1.9	-0.7	-1.2	1.9	-2.5
Mineral and other dietary supplements	0.3	0.4	0.7	-0.8	-0.7	0.4	0.6	0.7
Breast cancer (self-reported)	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.4	-0.2
Asthma (self-reported)	3.6	7.2	14.2	-1.1	1.0	-3.7	3.8	-2.3
Osteoporosis (self-reported)	1.0	1.2	2.5	1.6	1.1	0.7	-0.5	1.2
Osteoarthritis (self-reported)	1.6	2.1	4.4	-1.7	-1.4	-0.8	0.8	-2.1
Medication: Aspirin	0.9	1.2	3.0	0.1	1.6	-1.7	-0.1	0.6
Medication: Gliclazide	2.3	2.5	5.1	-1.6	1.4	-2.3	0.0	-1.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.0	0.9	-0.2	0.1	0.2
Smoking status: Current	2.1	3.3	6.4	-1.4	0.9	-2.5	-1.0	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	9.1	-0.1	-0.3	3.0	-1.5	2.0
Whole body water mass	0.6	3.3	6.4	-2.5	-0.5	-1.8	-0.7	-2.5
Leg predicted mass (right)	0.7	3.8	6.3	-2.0	0.3	-2.3	-1.8	-2.5
Arm fat mass (left)	1.4	5.8	14.9	-1.3	2.1	-3.9	-1.9	-2.2
Number of self-reported non-cancer illnesses	1.3	2.2	4.5	1.0	1.8	-1.6	2.1	0.3
Average weekly champagne plus white wine intake	1.4	1.9	4.7	-2.2	-1.5	0.5	1.1	-1.2
Miserableness	2.2	3.7	9.9	-0.8	3.1	-2.2	1.7	-0.5
Guilty feelings	2.1	3.2	5.8	1.4	2.4	-1.6	2.3	-0.3
Wears glasses or contact lenses	2.2	2.5	6.7	1.3	0.8	1.8	0.6	2.6
Ever taken oral contraceptive pill	1.3	1.4	2.6	1.2	1.6	-1.3	-1.0	-0.6
Hearing aid user	1.1	1.2	1.9	-1.0	-1.2	-1.4	-0.6	-1.2
Mother’s age at death	0.9	1.1	4.0	1.0	-0.6	2.0	0.4	0.4
Financial situation satisfaction	0.6	0.7	1.8	0.9	1.4	0.0	0.7	0.6
Tinnitus: Yes, now most or all of the time	1.6	1.9	4.0	1.6	-0.4	1.7	0.0	2.0
Commuting to job workplace: Public transport	1.1	1.3	2.0	1.3	1.2	0.7	-1.4	1.0
Eye problems/disorders: Glaucoma	0.5	0.6	0.8	0.8	-0.9	0.2	0.8	0.8
Medication: Blood pressure	0.7	1.3	3.5	-1.4	-0.5	-1.9	0.3	-0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	-0.0	0.0	-1.1	0.8	0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.4	-0.4	-0.2	-0.9	-0.3	-1.5
High cholesterol (Self-reported)	0.6	1.0	2.4	1.6	1.1	0.0	0.8	1.0
Medication: Bendroflumethiazide	1.1	1.6	4.6	-1.4	-0.5	-2.1	0.8	-0.8
Medication: Paracetamol	1.7	2.6	4.3	-1.8	1.4	-1.2	2.1	-1.6
Medication: Lisinopril	0.0	0.1	0.1	0.1	-0.3	-0.1	-0.3	0.3
Medication: Atorvastatin	1.0	1.3	2.3	0.1	1.5	-1.5	-1.3	0.3
Illnesses of father: High blood pressure	0.2	0.3	0.8	-0.5	-0.9	0.2	0.6	0.0
Alcohol drinker status: Never	2.1	2.5	7.9	0.9	-0.0	2.8	0.2	2.0
Ever smoked	0.1	0.2	0.3	0.5	0.4	-0.3	0.4	-0.3
Basal metabolic rate	0.7	4.0	7.1	-2.4	0.1	-2.5	-0.9	-2.7
Leg fat percentage (left)	1.8	6.4	19.6	-1.1	2.7	-4.4	-1.0	-1.7
Arm fat-free mass (left)	0.5	2.6	5.5	-2.3	-0.3	-1.7	-0.1	-2.2
Number of operations (self-reported)	0.6	0.9	3.3	-0.7	0.7	0.1	1.8	0.6
Average weekly beer plus cider intake	2.1	3.0	6.5	-0.6	2.0	-2.5	0.6	-1.9
Irritability	0.8	1.3	2.9	-1.2	1.1	-0.9	1.7	-0.4
Risk taking	2.0	2.9	7.9	-0.9	-0.7	-1.4	-1.8	-2.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.5	1.5	1.6	-1.1	1.2	0.2
Fractured/broken bones in last 5 years	3.1	4.0	12.0	2.5	3.5	-0.1	0.1	1.4
Age started oral contraceptive pill	2.3	2.9	8.9	-0.4	-2.0	3.0	1.2	0.4
Diastolic blood pressure, automated reading	0.3	0.8	2.6	-1.6	0.3	-0.2	-0.6	1.0
Ever depressed for a whole week	2.0	2.5	5.9	2.4	1.2	0.0	0.0	2.3
Unable to work because of sickness or disability	3.4	4.4	11.2	-0.6	3.2	-3.4	0.1	-0.4
Commuting to job workplace: Cycle	0.7	0.8	2.1	0.4	1.4	-0.9	0.1	0.9
Myopia	1.2	1.7	5.6	0.3	-0.1	2.4	-1.1	1.3
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.2	0.2	-2.5	2.3	-0.1	-1.5
Cholesterol lowering medication	0.2	0.2	0.6	-0.0	-0.8	-0.7	-0.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	4.4	5.3	12.3	2.0	3.5	-3.0	-0.5	1.1
Pain experienced in last month	0.4	0.7	1.5	1.2	-0.4	0.2	-0.6	1.2
Supplements: Calcium	0.8	0.9	3.0	1.7	0.5	0.2	0.6	0.9
Basal cell carcinoma (self-reported)	1.1	1.3	2.1	-1.4	0.0	-1.4	1.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.5	0.6	-0.1	0.0	0.3
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	4.2	1.6	2.1	-0.5	-0.9	1.2
Heart disease (siblings)	0.3	0.4	1.1	-1.0	0.3	-0.8	0.3	-0.1
Alcohol drinker status: Previous	1.1	1.2	4.8	-0.8	0.6	-2.2	0.6	-0.1
Pack years of smoking	1.3	1.9	5.5	-0.6	1.6	-1.0	-2.3	-0.0
Impedance of whole body	0.1	0.7	1.9	-0.1	0.5	-1.1	-0.0	1.4
Leg fat mass (left)	1.7	6.7	18.4	-1.5	2.7	-4.3	-1.4	-1.9
Arm predicted mass (left)	0.5	2.6	5.0	-2.2	-0.2	-1.7	-0.3	-2.2