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chr15:71,414,363-73,775,043

Best TWAS P=1.42e-30 · Best GWAS P=6.74e-29 conditioned to 0.0253

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Breast Mammary Tissue	MYO9A	0.19	0.02	lasso	8	0.03	9.4e-03	-10.9	11.5	2.2e-30	-0.88	0.02	0.94	TRUE
10	GTEx	Nerve Tibial	MYO9A	0.13	0.13	lasso	3	0.11	2.1e-08	-11.2	11.5	1.4e-30	-0.97	0.00	1.00	FALSE
1	GTEx	Adipose Subcutaneous	MYO9A	0.06	0.03	lasso	2	0.01	4.7e-02	-10.9	11.0	3.8e-28	-0.95	0.03	0.92	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	MYO9A	0.13	0.08	lasso	3	0.08	1.7e-03	-10.2	10.3	4.6e-25	-0.89	0.42	0.34	FALSE
2	GTEx	Artery Tibial	MYO9A	0.07	0.08	enet	11	0.09	2.5e-07	-10.8	10.3	1.1e-24	-0.94	0.07	0.93	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	NR2E3	0.03	0.06	lasso	1	0.05	3.8e-06	-10.0	10.0	1.3e-23	-0.83	0.00	1.00	FALSE
16	GTEx	Stomach	MYO9A	0.17	0.06	lasso	5	0.01	1.1e-01	-10.2	9.8	1.6e-22	-0.89	0.21	0.67	FALSE
9	GTEx	Lung	PARP6	0.09	0.03	lasso	5	0.01	8.1e-02	-11.2	-9.7	3.1e-22	0.96	0.02	0.96	FALSE
17	GTEx	Testis	CTD-2524L6.3	0.10	0.02	enet	13	0.03	2.1e-02	-9.5	9.6	8.4e-22	-0.82	0.08	0.73	FALSE
27	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NR2E3	0.07	0.02	blup	38	0.05	4.4e-03	-10.1	9.4	4.6e-21	-0.80	0.01	0.65	FALSE
19	YFS	Blood	MYO9A	0.02	0.02	lasso	3	0.02	5.3e-08	-9.2	9.3	1.2e-20	-0.92	0.32	0.68	FALSE
14	GTEx	Skin Sun Exposed Lower leg	PKM	0.05	0.06	lasso	6	0.05	3.9e-05	-9.4	-9.2	3.0e-20	0.92	0.28	0.71	FALSE
7	GTEx	Cells Transformed fibroblasts	MYO9A	0.06	0.04	lasso	5	0.03	3.8e-03	-9.5	9.1	7.3e-20	-0.93	0.12	0.82	FALSE
8	GTEx	Esophagus Mucosa	PKM	0.11	0.04	enet	20	0.06	6.4e-05	-10.4	-8.1	7.5e-16	0.77	0.08	0.91	FALSE
3	GTEx	Brain Cerebellum	MYO9A	0.18	0.12	lasso	2	0.06	6.3e-03	-7.3	7.5	8.5e-14	-0.67	0.09	0.27	FALSE
21	The Cancer Genome Atlas	Esophageal Carcinoma	SENP8	0.30	0.04	enet	22	0.12	1.2e-04	-10.8	7.5	8.9e-14	-0.57	0.00	0.72	FALSE
15	GTEx	Skin Sun Exposed Lower leg	CTD-2524L6.3	0.07	0.01	lasso	3	0.01	1.1e-01	-9.3	7.4	1.0e-13	-0.71	0.09	0.27	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	BBS4	0.03	0.00	enet	4	0.01	3.7e-02	-6.9	7.4	1.6e-13	-0.48	0.01	0.73	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	HEXA	0.01	0.01	enet	6	0.02	1.1e-04	-2.8	7.0	2.6e-12	-0.38	0.08	0.11	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BBS4	0.05	0.04	lasso	2	0.04	5.4e-05	-6.9	6.8	7.4e-12	-0.43	0.02	0.89	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	CTD-2524L6.3	0.18	0.12	enet	15	0.11	2.3e-04	-9.0	6.6	3.2e-11	-0.73	0.20	0.40	FALSE
18	GTEx	Thyroid	PARP6	0.23	0.02	enet	21	0.07	9.0e-06	-5.8	-6.6	5.2e-11	0.38	0.83	0.11	FALSE
12	GTEx	Pituitary	BBS4	0.27	0.02	enet	21	0.05	2.1e-02	-4.0	-6.3	2.2e-10	0.39	0.09	0.08	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NR2E3	0.05	0.02	blup	38	0.02	1.5e-03	-9.3	6.0	2.7e-09	-0.70	0.06	0.16	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	ADPGK	0.10	0.01	lasso	3	0.02	2.3e-02	-5.0	-5.8	4.8e-09	0.34	0.13	0.06	FALSE
11	GTEx	Nerve Tibial	PARP6	0.09	0.07	lasso	11	0.06	7.2e-05	-5.8	-5.8	6.1e-09	0.21	0.47	0.20	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	PKM2	0.06	0.00	enet	11	0.01	3.0e-02	-1.4	-5.8	8.2e-09	0.62	0.01	0.16	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	BBS4	0.04	0.01	blup	25	0.02	1.8e-03	-5.0	5.5	4.3e-08	-0.33	0.02	0.53	FALSE