Hub : Genes

BBS4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.0850 0.0360 1.5e-03 0.098 NA 0.086 NA 0.102 9.0e-08 NA 5.2e-07 NA 4.7e-08
2 GTEx Pituitary 0.2660 0.1200 4.9e-03 0.022 NA 0.051 NA 0.023 9.3e-02 NA 2.1e-02 NA 8.6e-02
3 GTEx Uterus 0.3230 0.1230 9.7e-03 0.048 NA 0.057 NA 0.061 3.9e-02 NA 2.8e-02 NA 2.3e-02
4 METSIM Adipose 0.0227 0.0140 2.4e-02 0.029 0.011 0.023 0.015 0.026 2.8e-05 6.5e-03 2.0e-04 2.1e-03 7.7e-05
5 YFS Blood 0.0660 0.0194 1.4e-09 0.049 0.037 0.046 0.053 0.052 9.2e-16 3.4e-12 6.3e-15 5.8e-17 1.1e-16
6 TCGA Head and Neck Squamous Cell Carcinoma 0.0515 0.0312 9.0e-04 0.043 0.029 0.026 NA 0.036 1.3e-05 2.9e-04 5.9e-04 NA 5.4e-05
7 TCGA Brain Lower Grade Glioma 0.0411 0.0257 1.3e-03 0.010 0.021 0.011 NA 0.011 2.0e-02 1.8e-03 1.6e-02 NA 1.6e-02
8 TCGA Pheochromocytoma and Paraganglioma 0.0870 0.0530 2.3e-03 0.026 0.041 0.044 NA 0.029 3.2e-02 9.3e-03 7.7e-03 NA 2.6e-02
9 TCGA Prostate Adenocarcinoma 0.0322 0.0244 6.0e-03 0.002 0.008 0.009 NA 0.007 1.9e-01 4.8e-02 3.7e-02 NA 6.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.2 0.4 1.1 0.6 -0.3 -0.4 0.9 0.7 0.2 1.0 -0.5 0.1
Bipolar Disorder or Schizophrenia 0.0 0.1 0.7 -0.1 0.0 0.1 0.8 -0.1 -0.3 0.1 -0.0 -0.4
Depressed Affect (Nagel 2018) 0.4 0.8 1.5 0.5 -1.1 1.1 0.3 0.7 0.9 0.3 1.2 1.1
Depression (Nagel 2018) 0.6 1.0 1.9 -1.2 0.6 0.9 -1.0 -1.0 -1.0 -1.4 0.8 -0.8
Intelligence (Savage-Jansen 2018) 0.1 0.3 1.2 -0.7 0.6 0.5 -0.2 -0.0 0.1 -0.6 -1.1 -0.5
Neuroticism (Nagel 2018) 0.2 0.5 1.5 0.5 -0.4 0.9 0.3 0.6 1.2 0.1 0.8 1.0
Schizophrenia (2018) 0.1 0.3 0.6 -0.6 0.3 0.5 0.3 -0.8 -0.6 -0.7 0.4 -0.6
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 0.5 0.7 0.5 0.7 0.4 0.2 0.0 -0.4 -0.0
Worry (Nagel 2018) 0.2 0.4 2.2 0.6 -0.0 -0.3 0.2 0.3 0.7 -0.0 1.5 0.8
Alzheimer’s Disease (in mother) 0.5 0.6 3.6 -0.7 -0.6 0.1 0.5 -0.6 0.4 -0.5 -1.9 0.4
Alzheimer’s Disease (in father) 1.4 1.5 3.9 1.5 -2.0 0.0 0.2 1.0 1.3 1.1 0.7 1.7
Alzheimer’s Disease (including proxy) 0.6 0.8 2.5 0.7 -1.3 0.0 0.7 0.3 1.3 0.6 -0.6 1.6
Crohns Disease (2017) 0.8 1.7 3.9 0.4 -0.3 -0.5 -2.0 -1.9 2.0 0.7 0.5 1.6
Irritable Bowel Disease (IBD) 0.2 0.6 1.6 0.1 0.5 -0.0 -1.1 -1.2 1.3 0.2 -0.1 0.7
Ulcerative Colitis (UC) 0.1 0.2 1.2 -0.2 1.1 0.5 0.1 -0.2 0.2 -0.3 -0.4 -0.5
Major Depression (MDD) 2.8 3.4 6.6 2.5 -2.6 -0.0 0.7 1.0 2.2 2.1 1.0 2.5
Reaction Time 1.4 2.7 6.8 2.2 -1.7 -0.6 -0.5 0.7 2.1 2.6 0.2 2.0
Verbal and Numeric Reasoning (VNR) 0.5 1.1 3.1 -1.3 0.4 0.3 -1.7 -1.7 -0.6 -0.6 -0.1 -1.2
Breast Cancer 0.3 0.8 1.8 1.2 -0.7 0.1 -0.3 0.1 1.2 1.3 0.5 1.2
Ovarian Cancer 1.1 1.5 3.2 0.3 0.7 1.4 1.7 1.8 -1.3 -0.7 1.4 -0.6
Prostate Cancer 0.3 0.4 3.1 -0.1 0.1 -1.8 -0.5 -0.0 -0.0 0.2 -0.2 -0.2
Age at First Birth 0.5 0.7 1.9 -0.4 1.4 0.9 0.6 0.5 -0.8 -1.1 -0.8 -0.5
Bipolar Disorder (2011) 1.2 1.1 4.1 0.8 -0.6 -2.0 -0.7 -0.5 1.1 1.5 0.6 0.5
Body Mass Index (BMI) (2010) 2.8 3.8 8.0 2.4 -2.8 -0.1 1.3 1.5 1.8 2.5 0.7 2.5
Coronary Artery Disease (CAD) 1.0 1.1 3.8 0.8 0.2 -1.3 1.4 0.8 1.2 -0.3 0.4 1.9
Crohns Disease (2012) 0.3 0.5 1.4 0.2 0.2 -0.2 -1.2 -0.9 0.9 0.5 0.5 0.6
Mean Putamen Volume 0.6 0.7 4.8 -0.6 0.1 -2.2 -0.3 -0.7 -0.5 -0.7 0.1 -0.2
Fasting Glucose 1.3 1.6 3.5 -1.2 1.9 -1.3 0.0 -0.2 -1.3 -1.9 -0.3 -1.5
HbA1C 0.5 0.6 2.3 0.5 -0.5 0.5 0.8 1.1 0.1 0.0 1.5 0.3
HDL Cholesterol 0.9 1.5 4.8 -1.0 1.8 0.6 0.1 0.3 -1.5 -2.2 0.2 -1.3
LDL Cholesterol 0.6 0.9 3.8 -0.7 -0.4 -0.1 -1.8 -2.0 0.2 0.3 -0.3 -0.2
Lupus 0.1 0.2 0.7 -0.2 -0.0 0.1 -0.9 -0.5 -0.5 -0.1 0.4 -0.7
Neuroticism (2016) 0.2 0.3 0.9 0.4 -0.7 -0.2 -0.1 -0.0 0.7 0.4 1.0 0.4
Primary Biliary Cirrhosis 0.4 0.6 1.7 -0.7 1.3 -0.6 -0.4 -1.0 -0.3 -0.1 -0.8 -0.9
Rheumatoid Arthritis 0.1 0.2 0.8 -0.3 0.1 -0.2 -0.5 -0.2 0.2 0.3 -0.9 -0.4
Schizophrenia (2014) 0.1 0.2 0.5 0.2 0.0 0.5 0.4 -0.5 0.6 0.5 0.7 0.3
Triglycerides 3.5 5.7 14.7 2.1 -3.8 -2.4 2.5 1.5 1.9 2.4 -0.3 2.8
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.1 0.2 -1.5 0.4 1.4 1.3 -0.7 0.1 0.5 -0.1
Ulcerative Colitis 0.3 0.4 2.2 -0.1 1.5 -0.1 0.5 0.1 0.4 -0.1 -0.8 -0.4
Blood Eosinophil Count 0.1 0.5 2.5 0.5 -0.5 -0.1 1.6 0.5 -0.8 -0.3 0.8 -0.0
Blood Platelet Count 0.6 6.4 16.0 2.9 -1.3 4.0 2.4 3.7 1.5 3.0 0.0 0.6
Blood Red Count 2.7 25.8 54.5 4.9 -6.3 -3.1 4.5 2.5 6.8 5.5 -0.2 7.4
Blood White Count 0.3 1.9 6.5 -0.7 -0.6 -2.2 -0.6 -0.8 -1.6 -1.2 2.5 -0.5
Heel T-Score 0.1 0.8 3.2 0.0 -0.9 -0.6 0.1 0.5 1.4 0.4 -0.5 1.8
BMI 2.0 11.4 32.0 3.4 -5.7 -2.8 2.4 1.1 1.5 2.6 4.0 4.5
Height 0.8 15.0 35.5 -4.1 5.0 -0.6 -3.5 -2.8 -4.9 -3.4 -1.6 -6.0
Waist Hip Ratio (WHR) 0.5 2.4 4.0 0.8 -1.8 1.4 1.4 1.5 2.0 1.8 -1.8 1.2
Systolic Blood Pressure 0.2 1.2 4.5 -1.2 0.7 -2.1 0.1 -0.4 0.4 -0.1 -2.1 -0.5
Smoking Status 0.4 0.9 3.2 0.4 -1.0 1.3 1.8 1.3 -0.4 -0.2 0.6 0.3
Allergy or Eczema 0.2 0.5 2.3 -0.5 1.5 -0.1 0.4 -0.2 0.3 -0.8 -0.8 0.2
Cardiovascular Disease 1.4 4.7 12.9 1.9 -3.6 -1.4 1.6 0.6 2.5 2.2 -0.2 3.1
Hypothyroidism (self reported) 1.7 3.9 8.8 1.9 -1.8 -0.7 2.0 1.6 2.6 2.1 -1.0 3.0
Respiratory disease 0.3 0.7 3.8 0.5 0.9 0.5 -0.8 -0.9 -0.3 0.2 2.0 0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.7 0.2 -1.2 1.2 0.9 1.3 -0.7 0.1 -0.2 -0.7
Lung FEV1/FVC ratio 0.3 1.4 5.2 -0.4 -2.3 1.6 -0.5 0.6 1.4 -0.2 -0.6 1.3
Lung FVC 1.0 5.0 11.9 -2.5 3.5 1.3 -1.8 -0.7 -1.7 -2.0 -1.9 -3.4
Neuroticism 0.5 1.1 3.0 0.6 -1.7 0.7 0.3 0.5 1.7 0.7 -0.3 1.5
Chronotype (morning person) 1.5 3.6 8.8 1.8 -2.3 -1.3 3.0 0.9 1.7 1.8 0.6 2.5
Hair Pigment 0.2 5.3 9.6 -3.1 2.9 -1.4 -2.4 -3.1 -1.3 -2.3 -1.7 -1.8
Tanning 0.1 1.1 2.5 -1.3 -0.3 0.5 -1.2 -1.6 -1.2 -1.2 -0.5 -0.9
Hand grip strength (left) 1.4 3.7 10.5 -2.0 2.6 -0.7 0.4 0.3 -2.3 -2.1 -1.4 -3.2
Number of treatments/medications taken 0.8 1.5 4.6 0.3 -2.0 -1.3 2.1 0.8 0.3 0.2 -0.9 1.2
Average weekly spirits intake 0.6 0.8 1.6 -1.3 0.6 -1.0 -0.3 -0.5 -0.9 -1.0 -0.9 -1.0
Sensitivity / hurt feelings 0.4 0.6 1.6 -0.4 -1.1 1.1 -1.3 -1.0 0.3 -0.3 -0.3 0.2
Frequency of depressed mood in last 2 weeks 0.4 0.6 2.8 -0.1 0.5 0.3 0.4 0.3 -1.1 -0.7 1.7 -0.5
Hearing difficulty/problems: Yes 3.2 4.9 10.0 2.9 -2.4 0.3 1.7 1.3 2.6 2.9 0.9 3.2
Relative age of first facial hair 0.2 0.4 1.8 -0.2 0.2 -0.3 0.1 -0.0 -1.3 0.5 0.1 -1.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 0.6 -0.0 0.4 -0.7 0.7 -0.2 0.7 0.7 -0.7 0.5
Ever used hormone-replacement therapy (HRT) 0.8 1.0 3.4 0.1 -0.9 1.8 1.6 0.9 -0.5 0.2 -1.1 -0.0
Ever had hysterectomy (womb removed) 0.7 0.8 3.7 0.2 0.5 0.3 1.9 1.1 0.3 0.3 -1.2 0.6
Systolic blood pressure, automated reading 0.2 0.7 3.0 -0.9 1.0 -1.1 0.2 -0.6 0.4 -0.1 -1.7 -0.1
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.6 0.4 -1.3 -0.5 0.7 0.5 0.0 0.7 0.2 0.4
Angina 1.5 2.0 5.2 1.6 -1.3 -1.1 -0.1 -0.1 1.9 1.2 1.5 2.3
Medication for hormone replacement therapy 0.4 0.5 2.2 0.4 0.7 -1.5 0.3 0.0 -0.2 1.0 -0.4 -0.3
Vitamin and mineral supplements 1.9 2.6 7.6 1.3 -2.7 -0.8 -0.9 -0.7 1.5 1.8 1.6 2.0
Supplements: Zinc 1.8 1.9 4.3 2.1 -0.1 0.5 1.7 1.9 1.5 1.4 0.9 1.2
Medication: Co-codamol 0.5 0.6 2.5 0.4 -1.6 0.5 -0.7 -0.5 -0.2 0.5 1.2 0.2
Medication: Metformin 1.1 1.6 4.9 1.5 -1.3 0.4 2.0 2.2 0.1 0.8 0.6 0.6
Diabetes (father) 1.0 1.2 3.0 1.7 -0.6 1.1 0.3 0.5 1.1 1.0 1.3 1.4
Diabetes (mother) 0.1 0.1 0.8 0.2 -0.3 -0.9 -0.2 -0.0 0.2 0.3 0.1 0.2
Severe depression (siblings) 0.7 0.7 5.1 0.2 0.5 2.3 -0.5 0.5 -0.3 -0.1 0.8 -0.2
Pack years adult smoking proportion 0.3 0.4 1.4 0.4 -1.2 0.5 0.4 0.1 0.6 0.7 -0.1 0.8
Impedance of leg (right) 0.1 0.5 1.7 0.3 -0.2 0.8 -1.0 0.2 0.0 0.9 -0.5 -1.3
Leg fat-free mass (left) 0.3 1.3 5.7 -0.0 -1.1 -2.4 -0.2 -0.9 -1.2 -0.5 1.5 0.3
Trunk fat percentage 2.2 8.7 35.4 3.0 -6.0 -1.9 0.9 0.2 1.2 3.0 2.9 3.3
Hand grip strength (right) 1.6 4.3 10.5 -2.3 2.4 -1.1 -0.8 -0.9 -2.6 -2.6 -1.1 -3.2
Townsend deprivation index at recruitment 0.4 0.6 1.2 0.7 -0.9 -1.0 0.3 0.5 1.1 1.1 -0.0 0.6
Current tobacco smoking 0.5 0.9 2.5 -0.7 0.3 -0.1 -0.3 -0.7 -1.6 -0.8 1.3 -1.4
Average weekly fortified wine intake 2.3 2.7 11.2 -1.4 3.3 1.2 -1.3 -0.7 -0.6 -1.2 -1.8 -1.5
Maternal smoking around birth 0.2 0.2 0.6 -0.4 -0.2 -0.5 -0.6 -0.4 -0.6 -0.4 0.8 -0.4
Fed-up feelings 0.1 0.3 1.5 -0.0 -0.2 1.2 -0.6 -0.0 0.4 0.1 0.6 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.6 -1.1 0.8 0.2 -1.1 -0.6 -1.6 -1.2 0.8 -1.6
Relative age voice broke 0.6 0.9 3.1 0.1 0.6 -0.2 0.8 0.9 -1.8 -0.4 0.4 -1.6
Taking other prescription medications 0.4 0.7 2.2 0.3 -1.2 0.6 1.5 0.6 0.1 0.2 -0.9 0.7
Age when periods started (menarche) 0.3 0.8 2.2 0.5 0.8 -0.1 0.2 0.8 -1.5 0.4 1.2 -1.3
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.6 1.0 -1.3 1.2 0.8 0.8 0.2 1.1 0.2 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.8 -1.4 1.3 -0.1 0.0 0.2 -0.2 -1.5 -1.9 -0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.0 0.2 -0.1 -0.4 1.0 1.0 -0.9 -0.4 0.2 -0.4
Qualifications: CSEs or equivalent 0.3 0.5 1.6 1.2 -0.5 0.2 0.1 0.3 0.8 1.0 0.7 0.3
Serious illness, injury or assault to yourself 0.9 1.1 4.5 -0.1 0.9 -2.1 1.2 0.4 0.8 -0.0 -1.3 0.7
High blood pressure 0.6 1.7 4.9 0.2 -1.7 -0.7 1.0 -0.6 1.8 0.7 -1.4 2.2
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.4 -0.1 0.3 0.5 0.4 0.1 0.6 -0.6 -0.2 0.4
Multivitamins +/- minerals 2.0 2.5 3.9 -1.0 1.5 2.0 1.7 1.4 -1.7 -1.8 -1.0 -2.0
Stomach or abdominal pain in last month 0.5 0.6 2.1 0.1 -1.0 -0.7 -0.6 -0.6 -0.9 -0.1 1.4 -0.5
Supplements: Glucosamine 1.3 1.6 4.8 -1.0 0.8 0.8 0.4 0.3 -2.2 -1.8 -0.1 -2.0
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 4.8 1.7 -2.1 -0.2 -0.0 -0.2 1.7 2.2 0.1 1.8
Medication: Atenolol 1.1 1.4 4.1 1.2 -1.5 -0.8 -0.0 -0.3 1.8 1.0 -0.2 2.0
Medication: Levothyroxine sodium 0.4 0.7 3.3 0.3 -0.6 -1.8 0.9 0.0 0.5 0.7 0.5 1.0
Sitting height 0.3 2.4 6.7 -1.8 2.6 -1.1 -0.4 -1.1 -1.3 -1.8 -1.0 -1.9
Chronic bronchitis/emphysema (father) 1.0 1.1 4.6 -1.0 1.5 -1.1 0.5 -0.3 -0.3 -0.6 -2.2 -0.4
High blood pressure (mother) 0.9 1.3 3.9 1.5 0.4 -0.1 0.6 0.6 2.0 1.5 -0.5 1.4
Body mass index (BMI) 1.9 8.1 25.3 2.9 -5.0 -2.1 1.4 0.7 1.4 2.4 3.1 3.8
Impedance of leg (left) 0.1 0.6 3.2 0.1 -0.1 0.8 -0.9 0.4 -0.6 0.6 -0.2 -1.8
Leg predicted mass (left) 0.2 1.3 5.8 -0.0 -1.1 -2.4 -0.1 -0.9 -1.2 -0.4 1.5 0.3
Trunk fat mass 1.6 7.1 28.2 2.6 -5.3 -2.1 0.7 -0.1 0.7 2.4 3.0 2.9
Waist circumference 2.0 7.4 26.8 2.5 -5.2 -2.8 0.9 0.3 1.2 2.4 2.6 3.3
Number of incorrect matches in round 0.5 0.8 3.8 -0.0 -1.9 0.3 -0.7 -0.9 0.8 0.4 0.3 0.9
Past tobacco smoking 1.2 2.1 4.8 -1.9 1.4 -0.0 -1.5 -1.4 -1.5 -1.2 -1.1 -2.2
Alcohol usually taken with meals 0.6 1.0 3.6 -1.2 1.0 0.2 0.0 0.2 0.0 -1.7 -1.9 0.3
Nervous feelings 0.9 1.6 4.3 1.1 0.3 2.1 -0.8 -0.1 1.6 0.5 2.0 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 4.1 -0.0 -0.0 -0.5 -0.4 -0.2 -0.1 -0.8 2.0 0.6
Hearing difficulty/problems with background noise 1.4 2.3 6.5 1.7 -2.6 -0.4 1.8 1.3 0.8 1.1 0.8 1.9
Hair/balding pattern: Pattern 2 0.6 0.8 1.7 -0.8 -0.5 1.1 1.1 1.1 -0.6 -1.3 -0.4 -0.5
Had menopause 0.6 0.7 1.7 -1.1 1.0 -0.0 0.5 -0.2 -1.3 -1.1 -0.9 -0.7
Had other major operations 0.8 0.9 3.7 0.9 -1.1 -0.4 0.2 -0.4 0.3 0.1 1.9 1.5
Forced vital capacity (FVC) 2.3 8.9 22.1 -3.4 4.1 -0.6 -2.2 -1.1 -3.1 -2.9 -2.2 -4.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 3.5 -1.0 0.6 0.2 -0.1 0.2 0.3 -1.2 -1.9 0.4
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 5.4 -0.1 -0.6 -0.1 -2.3 -1.9 0.0 -0.1 1.8 0.2
Qualifications: None of the above 0.6 1.3 4.0 0.9 -1.6 -0.7 1.3 0.5 0.2 0.4 2.0 1.2
Financial difficulties in last 2 years 0.5 0.7 2.1 -0.0 0.5 1.1 -1.4 -0.2 -0.7 -0.5 1.2 -0.7
Mouth/teeth dental problems 2.6 4.0 8.7 -1.7 3.0 1.4 0.6 1.1 -2.3 -2.3 -1.8 -2.7
Heart attack 2.1 2.7 7.2 2.0 -1.3 0.4 2.7 2.3 0.3 0.7 1.9 1.3
Allergy 0.1 0.1 0.3 -0.1 -0.5 -0.5 -0.1 0.5 -0.4 0.0 -0.3 -0.2
Pain all over the body in last month 0.8 0.9 2.0 1.2 -0.8 -1.3 0.2 0.8 0.6 0.5 0.8 1.4
Diabetes (self-reported) 0.4 0.6 1.7 -0.2 -0.4 1.3 0.4 0.9 -1.1 -0.5 0.4 -0.8
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 5.9 -0.1 -0.6 1.7 2.4 2.1 -0.8 -0.3 -0.5 -0.4
Medication: Ramipril 1.6 2.1 10.8 0.8 0.6 0.4 3.3 2.6 -0.2 -0.3 -0.3 0.0
Medication: Simvastatin 0.9 1.3 8.3 0.5 -2.9 -0.0 1.4 0.6 -0.1 0.0 0.5 0.9
Fluid intelligence score 0.3 0.6 2.3 -0.3 0.1 1.0 -1.5 -1.4 0.2 0.3 0.4 -0.2
Illnesses of siblings 2.1 2.9 9.2 -1.1 2.4 0.5 -2.0 -1.2 -2.0 -0.6 0.1 -3.0
Neuroticism score 0.4 0.9 2.7 0.8 -1.6 1.0 0.4 1.0 1.0 0.4 0.7 0.9
Weight 0.8 3.7 12.7 1.6 -3.6 -2.4 0.4 -0.2 -0.1 1.3 2.6 1.9
Impedance of arm (right) 0.2 0.7 1.8 0.3 -0.7 1.3 -0.1 0.4 0.0 1.1 -1.2 -1.1
Arm fat percentage (right) 2.5 9.7 35.9 3.2 -6.0 -1.9 1.1 0.2 1.6 3.1 3.1 3.9
Trunk fat-free mass 0.3 1.6 3.9 -1.2 0.9 -1.8 -0.5 -0.9 -2.0 -1.5 0.7 -1.1
Hip circumference 1.2 5.3 13.2 1.8 -3.6 -3.6 0.0 -0.3 -0.3 1.1 3.5 2.2
Time employed in main current job 1.2 1.4 4.4 -1.0 2.1 -1.6 -0.6 -0.6 -0.9 -1.1 -0.3 -1.3
Alcohol intake versus 10 years previously 0.4 0.6 3.5 -0.5 -1.9 -0.3 -0.3 -0.7 -0.7 -0.3 0.3 -0.2
Father’s age at death 0.4 0.5 1.1 1.1 0.9 1.0 0.3 0.8 0.6 0.3 0.7 0.3
Worrier / anxious feelings 0.4 0.8 2.3 0.6 -0.4 1.4 1.4 1.5 0.5 -0.1 -0.1 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.9 -0.1 0.0 -0.7 -0.9 -0.3 -0.1 -0.1 0.9 -0.3
Falls in the last year 0.6 0.7 2.0 0.8 -1.1 -0.4 1.4 0.8 0.6 0.3 0.2 1.3
Hair/balding pattern: Pattern 3 0.5 0.7 2.1 0.5 0.7 -1.2 -1.0 -0.3 -0.5 0.7 1.5 -0.3
Number of live births 0.9 1.3 3.3 -1.3 0.3 -0.0 -1.8 -1.3 -1.1 -1.4 0.3 -1.1
Forced expiratory volume in 1-second (FEV1) 2.0 6.8 15.8 -3.2 3.1 -0.1 -1.9 -0.7 -2.5 -2.8 -2.6 -4.0
Pulse rate 4.6 7.7 31.5 2.3 -5.6 -2.1 1.2 0.8 2.2 2.5 1.5 3.6
Happiness 1.1 1.3 6.0 -0.4 0.7 2.4 0.2 0.9 -1.4 -0.3 0.4 -1.5
Noisy workplace 0.7 0.9 4.2 -0.7 -0.2 -2.0 -0.5 -0.7 -1.0 -0.3 0.3 -1.1
Qualifications: A levels/AS levels or equivalent 1.9 4.2 16.7 -2.8 2.2 -0.3 -0.6 -1.7 -0.3 -1.9 -4.1 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.9 2.6 -0.8 1.5 -0.2 0.2 0.6 -0.6 -1.1 -1.6 -0.6
Mouth/teeth dental problems: Dentures 3.9 6.6 16.4 2.4 -4.0 -1.3 0.8 0.1 2.7 2.6 2.6 3.7
Asthma 0.4 0.8 2.6 0.5 1.1 0.5 -1.1 -1.3 0.2 0.3 1.6 0.3
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 7.3 0.2 -1.3 -2.7 1.2 0.8 0.8 0.9 -1.7 0.8
Medication: Cholesterol lowering 3.0 4.6 7.8 2.3 -2.8 1.4 2.0 2.0 2.2 2.4 0.3 2.7
Depression (self-reported) 0.5 0.6 1.9 0.2 -0.6 0.1 1.4 1.4 -0.9 -0.3 -0.3 -0.1
Medication: Lansoprazole 0.9 1.1 5.8 0.7 -2.4 -0.8 0.6 0.5 0.2 0.1 0.8 1.0
Prospective memory result 0.1 0.2 0.6 0.1 0.2 -0.4 -0.3 -0.8 0.3 0.5 0.2 0.6
Lung cancer (father) 2.5 2.9 8.4 2.2 -1.2 -0.3 -0.4 -0.5 2.5 2.9 0.8 2.0
Illnesses of mother 1.6 2.0 6.2 -1.4 0.3 1.2 0.4 0.6 -2.5 -1.6 -0.1 -2.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 7.8 17.8 -3.6 3.4 -0.9 -2.0 -1.1 -2.6 -2.9 -2.7 -4.2
Pulse wave Arterial Stiffness index 0.6 0.7 4.2 0.6 -0.1 -1.2 0.2 0.2 0.0 0.4 2.1 0.5
Impedance of arm (left) 0.2 0.7 2.2 0.8 -1.3 0.9 -0.0 0.5 0.6 1.5 -0.7 -0.5
Arm fat mass (right) 1.7 7.1 26.1 2.6 -5.1 -2.1 0.8 0.0 0.9 2.4 3.2 3.2
Trunk predicted mass 0.2 1.3 3.2 -1.1 0.8 -1.7 -0.4 -0.8 -1.8 -1.4 0.6 -0.9
Standing height 0.6 6.0 14.7 -2.6 2.7 -1.0 -2.0 -1.8 -3.2 -2.3 -1.0 -3.8
Length of working week for main job 1.3 1.4 3.1 1.3 -0.6 -0.4 1.2 1.3 1.4 1.8 0.1 1.5
Exposure to tobacco smoke at home 1.8 2.0 4.0 -0.7 0.7 -2.0 -1.8 -1.5 -1.5 -0.7 1.6 -1.5
Breastfed as a baby 2.4 3.0 7.2 -2.0 1.2 0.2 1.6 0.8 -1.4 -2.6 -2.7 -1.4
Tense / ‘highly strung’ 0.3 0.5 1.7 -0.3 0.1 -0.9 -0.1 -0.3 0.4 -1.0 1.3 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.7 -0.1 0.0 -0.1 -0.3 -0.5 0.6 -0.3 0.1 0.8
Hair/balding pattern: Pattern 4 0.9 2.1 5.1 2.3 -1.5 -0.7 1.5 1.5 0.8 1.5 1.0 1.5
Birth weight of first child 0.9 1.6 7.0 -1.4 1.5 0.8 0.8 0.2 0.4 -1.5 -2.6 0.0
Peak expiratory flow (PEF) 0.9 2.1 4.1 -2.0 1.5 -0.6 -0.6 -0.3 -1.0 -1.9 -2.0 -1.8
Pulse wave reflection index 1.2 1.5 4.1 0.4 2.0 -0.0 1.9 1.7 -0.9 -0.3 0.4 -1.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.7 -0.5 -0.1 -0.8 -1.2 -1.3 -0.6 -0.8 1.1 -0.3
Loud music exposure frequency 1.0 1.1 2.6 -1.1 0.6 -1.4 1.0 0.6 -1.0 -1.6 -0.9 -0.9
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 4.4 -1.1 0.9 1.0 -1.7 -1.2 0.7 -0.2 -2.1 -0.4
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 5.3 -1.1 1.4 -0.4 -2.3 -2.1 -0.1 -0.4 0.0 -0.4
Blood clot in the leg (DVT) 0.4 0.5 2.6 0.5 0.3 -0.1 0.6 0.4 -0.9 0.4 1.6 -0.5
Medication: Paracetamol 2.7 4.5 11.3 2.1 -3.4 -2.2 1.1 0.3 2.2 2.2 1.2 2.7
Headache pain in last month 4.1 7.0 15.8 2.3 -3.9 -2.3 1.1 -0.1 3.7 2.5 0.4 4.0
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 9.0 -1.6 2.3 -0.1 -1.6 -1.0 -2.5 -1.6 0.7 -3.0
Glaucoma (self-reported) 1.6 1.9 7.2 -2.3 0.3 0.1 0.7 0.2 -1.3 -2.7 -1.2 -1.0
Gout (self-reported) 3.0 4.1 8.0 2.8 -2.2 1.3 0.7 0.9 2.6 2.8 0.9 2.5
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 4.7 1.2 -1.6 -1.6 1.3 0.6 1.8 1.7 -0.7 2.2
Medication: Amlodipine 0.6 0.9 3.5 -1.3 -0.2 -0.3 -0.9 -1.9 -0.7 -1.1 -0.1 -0.1
Medication: Ventolin 100micrograms inhaler 0.5 0.6 2.5 1.2 -0.4 -0.4 0.6 0.4 -0.1 0.7 1.6 0.5
Birth weight 0.7 1.5 3.7 1.1 -1.1 -0.4 1.9 1.3 1.2 0.4 0.5 1.9
Chronic bronchitis/emphysema (mother) 0.9 1.1 3.6 -0.6 0.8 -1.9 -1.4 -1.0 -0.9 -0.5 0.4 -1.1
High blood pressure (siblings) 3.6 5.3 12.1 2.6 -2.9 -0.8 1.9 1.4 2.9 2.0 1.1 3.5
Forced vital capacity (FVC), Best measure 2.9 10.6 25.1 -3.8 4.5 -1.3 -2.3 -1.6 -3.3 -3.1 -2.3 -5.0
Body fat percentage 2.6 10.2 39.3 3.4 -6.3 -1.8 1.0 0.4 1.4 3.2 3.3 3.7
Leg fat percentage (right) 3.2 11.6 40.9 3.7 -6.4 -1.8 0.8 0.4 1.8 3.5 3.6 4.1
Arm fat-free mass (right) 0.2 0.9 4.7 -0.3 -0.5 -2.2 0.1 -0.5 -1.1 -0.7 1.2 0.2
Exposure to tobacco smoke outside home 0.2 0.2 0.7 -0.6 -0.2 0.0 0.3 0.6 -0.4 -0.9 0.1 -0.2
Comparative body size at age 10 1.5 4.2 11.5 1.8 -3.1 -0.9 0.5 -0.2 2.9 1.9 0.7 3.4
Number of full brothers 0.2 0.2 0.5 -0.7 -0.6 0.1 0.7 0.0 -0.1 -0.6 0.1 0.2
Worry too long after embarrassment 0.4 0.7 2.2 0.3 -0.8 1.3 0.2 0.3 1.5 0.1 -1.1 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.5 0.2 0.1 -0.7 -0.5 -0.4 0.5 0.2 -0.1 0.6
Wheeze or whistling in the chest in last year 0.7 1.3 4.2 1.8 -0.6 -0.1 0.8 0.6 0.3 1.4 2.1 0.9
Number of children fathered 0.5 0.6 1.1 0.9 -0.4 0.9 1.1 0.8 -0.1 0.5 1.0 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 4.2 -0.2 -0.2 1.1 -0.9 -0.6 1.2 0.9 -2.0 0.3
Age at first live birth 0.7 1.3 5.0 -0.7 2.2 1.2 0.0 -0.1 -0.0 -0.5 -1.9 -0.6
Pulse wave peak to peak time 0.6 0.7 3.7 -0.4 0.4 1.5 -0.2 -0.0 -0.0 -0.2 -1.9 -0.5
Health satisfaction 1.5 2.0 9.5 1.3 -3.1 -0.1 1.0 0.7 0.3 1.4 1.1 1.4
Shortness of breath walking on level ground 0.3 0.4 2.1 -0.3 -0.6 -1.5 0.4 0.1 -0.7 -0.1 0.1 -0.1
Qualifications: College or University degree 0.4 1.3 4.6 -1.1 2.1 0.8 0.4 0.5 -0.2 -1.2 -1.8 -0.6
Eye problems/disorders: None of the above 1.1 1.3 3.0 1.5 -1.0 -1.1 -0.6 -0.0 1.7 1.5 0.2 1.3
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.7 0.1 0.1 0.7 1.3 1.3 -1.1 -0.3 0.8 -0.7
Emphysema/chronic bronchitis 1.4 1.6 3.5 1.9 -1.2 -0.0 1.6 1.9 0.2 1.5 1.1 0.5
Medication for pain relief, constipation, heartburn 1.3 2.2 7.7 -0.9 2.8 1.7 -1.0 -0.1 -1.4 -1.4 0.1 -1.8
Neck or shoulder pain in last month 0.3 0.4 1.6 0.3 -1.3 -0.0 0.8 0.7 0.3 0.2 -0.1 0.5
Medication: Blood pressure 1.0 1.8 5.1 0.9 -0.9 -0.0 1.5 0.7 2.1 0.9 -1.2 2.3
Angina (self-reported) 1.6 2.2 5.8 1.7 -1.5 -0.8 0.1 0.1 1.9 1.2 1.6 2.4
Migraine (self-reported) 1.5 1.9 8.5 0.7 -0.2 0.2 2.9 2.3 -0.3 0.4 -1.6 -0.3
Medication: Ibuprofen 1.2 1.5 10.2 -0.3 -0.7 -3.2 0.8 0.2 0.1 0.3 -1.3 0.2
Medication: Allopurinol 2.1 2.8 8.1 2.1 -1.9 1.9 0.2 0.3 1.7 2.8 0.4 1.3
Medication: Omeprazole 0.6 0.7 3.0 0.9 -0.9 -0.5 -0.3 -0.0 0.8 1.7 0.0 0.8
Medication: Seretide 50 evohaler 0.3 0.3 1.2 1.1 0.8 0.4 0.2 0.4 -0.2 0.7 0.4 0.0
Mean time to correctly identify matches 1.4 2.6 7.8 2.3 -1.7 0.1 -0.2 0.8 1.7 2.8 1.1 1.8
Heart disease (mother) 2.4 2.9 6.7 1.7 -1.9 -1.1 -0.4 -0.2 2.6 2.2 -0.3 2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.6 0.1 -0.4 -0.3 0.2 0.2 0.8 0.5 -0.6 0.7
Whole body fat mass 1.9 7.7 29.8 2.8 -5.5 -1.9 0.5 -0.1 0.7 2.4 3.5 3.0
Leg fat mass (right) 2.3 8.9 32.6 3.0 -5.7 -2.2 0.5 -0.1 0.9 2.6 3.7 3.4
Arm predicted mass (right) 0.2 0.9 4.3 -0.3 -0.3 -2.1 0.1 -0.5 -1.1 -0.8 1.2 0.2
Pulse rate, automated reading 4.8 15.5 55.8 3.0 -7.5 -3.2 3.1 2.1 3.5 4.0 -0.0 4.7
Alcohol intake frequency. 0.8 1.8 6.9 -0.8 -2.6 -2.3 -0.6 -1.6 -0.2 -0.3 0.7 0.2
Comparative height size at age 10 1.3 7.2 11.6 -3.1 2.6 -0.3 -3.0 -2.7 -3.1 -3.4 -0.2 -3.3
Number of full sisters 0.6 0.7 3.0 0.1 0.0 -1.7 -1.2 -1.3 0.2 0.5 0.6 -0.1
Suffer from ‘nerves’ 0.3 0.4 1.6 0.6 0.2 0.6 0.1 0.6 0.5 -0.2 1.3 0.8
Overall health rating 1.7 3.6 8.5 2.2 -2.9 -0.7 1.7 1.3 1.6 1.8 1.2 2.6
Chest pain or discomfort 1.2 1.7 3.5 1.9 -1.1 -0.2 1.2 1.3 1.0 1.3 1.6 1.6
Had major operations 0.7 0.8 2.5 -1.4 0.1 -0.4 -0.5 -0.9 -0.9 -1.6 -0.6 -0.6
Age at last live birth 0.7 1.1 2.9 -0.8 1.7 0.3 0.3 0.3 -1.0 -0.8 -1.6 -1.2
Family relationship satisfaction 1.2 1.5 9.6 -0.1 0.4 3.1 0.8 0.9 -1.0 -0.1 0.1 -1.2
Leg pain on walking 0.6 0.7 2.5 -1.6 0.2 -0.7 -0.6 -0.7 -0.6 -1.0 -0.9 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 2.7 0.6 0.1 -1.6 0.3 0.3 -0.0 0.7 0.0 -0.3
Commuting to job workplace: Car/motor vehicle 1.7 2.0 6.6 -0.0 0.7 -0.5 0.3 0.8 -2.4 -0.9 2.6 -1.7
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 5.2 1.0 -2.3 -0.6 0.9 0.2 0.8 0.9 0.6 1.3
Medication: Aspirin 0.6 0.7 1.6 -1.2 -0.2 0.2 0.4 0.0 -1.3 -1.2 -1.1 -0.9
Supplements: Vitamin C 1.6 1.9 7.5 -1.2 2.7 -0.3 -0.2 0.1 -0.9 -1.3 -1.6 -1.6
Knee pain experienced in last month 2.8 4.3 9.9 2.5 -3.1 -1.3 0.1 -0.1 2.2 2.5 1.0 3.0
Hypertension (Self-reported) 0.6 1.8 4.6 0.3 -2.0 -0.4 1.4 -0.3 1.8 0.7 -1.3 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 2.7 0.4 -0.9 -0.1 -1.6 -1.4 1.6 1.2 -0.6 1.0
Illnesses of father: Heart disease 0.9 1.2 3.4 1.2 0.4 1.4 1.8 1.7 0.3 0.7 0.8 0.4
Illnesses of siblings: Diabetes 1.0 1.2 3.1 0.7 -1.8 0.6 1.5 0.7 0.9 0.8 -0.8 1.4
Smoking status: Previous 1.7 2.6 6.2 1.4 -1.3 0.5 2.5 2.3 1.5 0.7 -0.8 2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.3 -1.1 2.1 -0.2 -1.1 -0.3 -1.7 -1.2 -0.5 -2.0
Whole body fat-free mass 0.2 1.2 4.1 -0.6 0.1 -2.0 -0.2 -0.7 -1.7 -1.1 1.1 -0.5
Leg fat-free mass (right) 0.2 1.3 5.4 -0.4 -0.7 -2.3 -0.1 -0.8 -1.6 -0.9 1.4 -0.1
Arm fat percentage (left) 3.1 12.3 42.9 3.7 -6.5 -1.9 1.4 0.6 2.1 3.6 3.2 4.4
Average weekly red wine intake 1.3 1.9 10.4 -0.9 3.2 -0.1 -1.5 -0.8 -0.5 -1.3 0.3 -1.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 1.1 -0.1 1.1 -0.7 0.2 0.0 -0.1 -0.1 -0.5 -0.4
Mood swings 0.9 1.6 6.1 0.9 -2.5 -0.0 0.2 0.4 1.3 0.6 1.6 1.7
Loneliness, isolation 0.7 1.0 1.5 1.1 -1.2 0.8 0.8 1.1 0.9 1.0 0.9 0.8
Long-standing illness, disability or infirmity 0.7 1.1 3.3 0.6 -1.2 -1.0 1.8 0.7 0.8 0.6 -0.2 1.4
Ever had bowel cancer screening 0.5 0.6 1.7 0.5 -1.2 1.3 0.8 1.0 0.1 0.4 0.5 0.5
Diabetes diagnosed by doctor 0.5 0.8 2.0 0.7 -1.3 1.1 1.1 1.4 -0.2 0.4 0.4 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.4 -0.1 1.2 -0.4 -0.0 0.3 0.6 -0.5 -0.7 0.1
Friendships satisfaction 0.8 0.9 4.3 0.3 -0.3 2.1 0.5 1.2 -0.9 0.3 0.7 -1.0
Qualifications: nursing, teaching 1.8 2.8 5.5 -2.3 2.0 -0.2 -1.4 -1.3 -1.2 -1.6 -2.3 -1.7
Commuting to job workplace: Walk 0.7 0.8 2.8 0.0 -1.0 0.3 0.1 -0.6 1.3 0.8 -1.7 0.9
Eye problems/disorders: Cataract 1.1 1.3 3.6 -1.5 0.6 0.6 0.3 -0.0 -1.9 -1.9 0.0 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 3.5 0.9 -1.9 -0.9 0.7 -0.2 1.0 1.2 -0.2 1.0
Medication for cholesterol 0.8 1.2 6.1 -0.1 2.5 1.3 -1.4 -0.0 0.7 -0.0 -0.5 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 3.4 0.5 -1.0 0.7 1.8 0.7 0.6 0.3 -0.4 1.0
Back pain experienced in last month 0.6 0.9 4.6 -0.9 -0.0 -2.1 0.3 -0.1 -0.2 -0.9 -1.3 0.3
Mineral and other dietary supplements 1.5 2.1 4.7 0.8 -0.6 -2.2 -1.2 -1.2 1.8 1.6 1.2 1.7
Breast cancer (self-reported) 1.2 1.4 3.7 -1.5 0.8 -1.3 -1.2 -1.9 -0.3 -1.8 0.1 0.1
Asthma (self-reported) 0.5 1.0 2.8 0.5 1.4 0.4 -1.3 -1.4 0.2 0.4 1.7 0.2
Osteoporosis (self-reported) 1.2 1.4 3.3 1.5 -0.9 0.8 1.3 1.5 1.2 1.8 -0.1 0.9
Osteoarthritis (self-reported) 0.3 0.4 1.3 -0.9 -0.7 -0.6 0.5 -0.3 -1.1 -0.8 0.1 -0.3
Medication: Aspirin 0.4 0.5 1.2 -0.5 -0.4 0.0 1.1 0.7 -0.7 -0.7 -1.1 -0.2
Medication: Gliclazide 0.3 0.4 0.6 0.6 -0.8 -0.3 0.8 0.8 0.4 0.7 -0.5 0.6
Illnesses of father: None of the above (group 1) 1.3 1.6 3.6 -1.9 1.1 0.4 -1.2 -0.9 -1.2 -1.2 -1.0 -1.8
Smoking status: Current 0.7 1.1 3.5 -0.5 0.2 -0.4 -0.9 -1.1 -1.4 -0.7 1.9 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 4.9 -1.2 1.8 0.5 0.2 0.5 -0.1 -0.9 -2.2 -1.2
Whole body water mass 0.2 1.1 3.8 -0.6 0.1 -1.9 -0.1 -0.7 -1.6 -1.0 1.1 -0.4
Leg predicted mass (right) 0.3 1.3 5.5 -0.3 -0.8 -2.3 -0.1 -0.8 -1.6 -0.8 1.4 -0.1
Arm fat mass (left) 2.1 8.4 30.0 2.9 -5.5 -2.1 0.9 0.1 1.2 2.7 3.3 3.5
Number of self-reported non-cancer illnesses 0.4 0.6 4.3 -0.6 -2.1 0.3 0.6 -0.6 -0.3 -0.2 -0.3 0.2
Average weekly champagne plus white wine intake 1.8 2.5 6.6 1.6 -0.5 -0.1 0.4 1.2 2.6 2.1 -1.8 1.9
Miserableness 0.7 1.2 2.7 1.0 -0.3 1.1 1.3 1.5 1.6 0.4 0.1 1.3
Guilty feelings 0.3 0.4 1.7 -0.6 -0.3 1.3 0.4 -0.2 0.3 -0.8 -0.6 0.1
Wears glasses or contact lenses 1.5 1.8 6.6 1.1 -2.6 -1.1 0.0 -0.3 0.8 1.3 0.9 1.9
Ever taken oral contraceptive pill 0.4 0.5 1.3 0.5 1.0 1.1 -0.5 -0.2 0.9 0.6 0.3 0.5
Hearing aid user 0.2 0.3 1.3 -0.0 -0.8 -0.5 1.1 0.2 -0.6 0.1 -0.1 -0.0
Mother’s age at death 0.7 0.9 2.0 -0.8 0.8 0.9 -0.3 -0.2 -1.3 -1.2 1.4 -0.7
Financial situation satisfaction 0.7 0.9 3.2 -0.5 -1.2 0.4 -1.8 -1.3 -0.0 0.1 0.9 -0.2
Tinnitus: Yes, now most or all of the time 2.3 2.7 6.0 1.9 -2.3 -1.3 0.5 0.1 1.6 2.4 1.0 1.9
Commuting to job workplace: Public transport 0.7 0.9 2.5 -0.2 -1.2 0.5 -0.5 -0.1 1.4 0.2 -1.6 1.2
Eye problems/disorders: Glaucoma 0.6 0.7 1.8 -0.9 0.5 1.3 0.6 0.6 -0.7 -1.4 -0.6 -0.4
Medication: Blood pressure 0.4 0.8 3.7 -0.8 -1.9 -0.4 0.6 -0.6 -0.6 -1.2 0.3 0.1
Pain type(s) experienced in last month: Hip pain 1.8 2.3 6.1 1.9 -1.3 0.3 0.6 0.8 1.9 1.5 1.3 2.5
Supplements: Fish oil (including cod liver oil) 2.1 2.7 5.9 -1.7 1.4 1.7 0.3 0.4 -2.1 -2.4 -1.2 -2.2
High cholesterol (Self-reported) 1.0 1.8 10.4 0.5 -3.2 0.0 1.6 0.8 0.1 0.5 0.4 1.1
Medication: Bendroflumethiazide 0.4 0.5 1.4 -0.6 -1.0 -0.2 0.1 -0.6 1.2 -0.5 -0.3 1.2
Medication: Paracetamol 3.7 5.8 11.3 2.6 -3.4 -2.2 2.2 1.3 2.2 2.6 1.7 2.8
Medication: Lisinopril 0.7 0.9 2.6 0.8 -0.6 -1.6 -0.1 -0.6 1.4 0.9 -0.2 1.3
Medication: Atorvastatin 3.0 3.7 6.6 2.2 -2.4 -1.0 2.6 2.0 1.4 2.0 0.5 2.3
Illnesses of father: High blood pressure 0.5 0.7 2.4 0.9 -1.6 0.1 0.3 0.2 0.9 0.7 0.1 1.1
Alcohol drinker status: Never 0.8 0.9 1.4 -1.1 -0.9 -0.7 -1.1 -1.1 -1.2 -0.9 0.1 -1.1
Ever smoked 0.4 0.7 1.4 1.0 -0.6 0.8 1.1 1.2 0.3 0.7 0.7 0.5
Basal metabolic rate 0.2 1.2 5.2 -0.0 -0.9 -2.3 -0.1 -0.7 -1.3 -0.4 1.6 0.1
Leg fat percentage (left) 3.1 11.1 39.6 3.7 -6.3 -1.9 1.0 0.7 1.5 3.3 3.6 3.9
Arm fat-free mass (left) 0.2 1.0 4.0 -0.4 -0.1 -2.0 -0.0 -0.6 -1.5 -0.6 1.2 -0.3
Number of operations (self-reported) 0.7 1.0 3.5 0.3 -1.9 -1.2 1.4 0.1 0.1 -0.1 -0.1 1.3
Average weekly beer plus cider intake 1.4 2.0 4.9 -0.7 -0.6 -1.5 -1.8 -1.8 -1.3 -0.8 2.2 -1.1
Irritability 0.3 0.5 1.6 -0.9 1.2 0.2 -0.1 0.3 0.0 -1.0 -1.0 -0.6
Risk taking 0.5 0.7 1.6 0.6 -0.1 1.3 1.1 1.0 0.7 0.4 -0.2 1.2
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.3 0.5 -0.8 0.7 1.2 0.9 0.4 0.1 -1.0 1.1
Fractured/broken bones in last 5 years 0.3 0.4 1.1 0.7 1.0 -0.3 0.6 0.4 0.6 0.8 0.4 0.4
Age started oral contraceptive pill 0.3 0.3 1.2 -0.4 0.0 1.1 0.9 0.1 0.3 -0.4 -0.2 0.6
Diastolic blood pressure, automated reading 0.8 2.6 13.2 0.8 -1.6 -3.6 1.5 0.1 0.9 1.1 -0.4 1.5
Ever depressed for a whole week 0.2 0.2 0.6 -0.0 0.5 0.8 -0.1 0.0 0.1 -0.4 0.8 0.5
Unable to work because of sickness or disability 0.4 0.5 1.9 0.5 -0.5 -0.3 -0.5 -0.7 0.8 0.7 0.1 1.4
Commuting to job workplace: Cycle 1.5 1.8 4.4 -1.8 1.4 -0.5 -0.5 -0.8 -1.5 -1.5 -1.0 -2.1
Myopia 0.7 1.0 2.7 -1.3 0.0 0.2 0.2 0.3 -1.6 -1.5 -0.5 -1.7
Vascular/heart problems diagnosed by doctor 0.9 2.4 7.3 -0.9 2.3 0.6 -1.4 0.2 -2.1 -1.1 1.0 -2.7
Cholesterol lowering medication 1.2 1.8 5.3 -0.2 -2.3 -2.0 2.0 0.6 -1.1 -0.8 0.6 0.3
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.2 0.8 -0.9 0.1 0.1 0.4 0.7 1.5 -0.6 0.6
Pain experienced in last month 1.9 3.1 9.5 -1.1 2.6 3.1 -0.4 0.8 -1.4 -1.2 -0.8 -2.3
Supplements: Calcium 0.9 1.0 3.9 -1.2 0.8 2.0 -0.1 -1.0 -0.3 -1.3 -0.6 -0.5
Basal cell carcinoma (self-reported) 0.2 0.2 0.7 0.5 -0.3 -0.3 0.7 0.8 0.4 0.6 -0.1 0.3
Heart attack/myocardial infarction (self-reported) 2.1 2.7 7.3 1.8 -1.3 0.8 2.7 2.4 0.1 0.5 2.0 1.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.3 0.3 0.5 -0.0 0.5 0.4 -1.0 0.3 1.5 -0.7
Heart disease (siblings) 0.1 0.2 0.7 -0.2 -0.3 -0.1 0.0 -0.6 0.2 -0.4 0.2 0.8
Alcohol drinker status: Previous 0.3 0.3 1.0 0.3 -0.1 0.3 0.4 0.3 1.0 0.7 -0.8 0.7
Pack years of smoking 0.5 0.8 2.3 0.5 -1.5 0.4 0.4 -0.1 1.1 0.9 -0.3 1.4
Impedance of whole body 0.1 0.5 1.3 0.4 -0.7 1.0 -0.4 0.5 0.1 1.0 -0.7 -1.2
Leg fat mass (left) 2.1 8.1 30.3 2.9 -5.5 -2.3 0.6 0.1 0.7 2.5 3.5 3.2
Arm predicted mass (left) 0.2 1.1 3.9 -0.5 -0.0 -2.0 -0.0 -0.6 -1.6 -0.9 1.3 -0.2