Hub : Genes

PARP6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.2410 0.0950 9.5e-05 0.063 NA 0.038 NA 0.075 4.2e-03 NA 2.1e-02 NA 1.9e-03
2 GTEx Lung 0.0856 0.0528 1.8e-03 0.034 NA 0.007 NA 0.007 1.3e-03 NA 9.4e-02 NA 8.1e-02
3 GTEx Nerve Tibial 0.0927 0.0460 2.9e-03 0.068 NA 0.036 NA 0.057 1.5e-05 NA 1.3e-03 NA 7.2e-05
4 GTEx Thyroid 0.2270 0.0810 6.7e-05 0.020 NA 0.066 NA 0.030 1.1e-02 NA 9.0e-06 NA 2.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.3 0.5 1.6 -0.5 -1.3 0.4 0.2
Bipolar Disorder or Schizophrenia 0.7 1.8 6.4 -0.6 -2.5 0.1 -0.5
Depressed Affect (Nagel 2018) 0.3 0.7 1.6 -0.3 -0.2 -1.3 -1.0
Depression (Nagel 2018) 0.1 0.1 0.2 -0.2 0.4 -0.4 0.3
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.2 -1.1 0.3 0.4 0.9
Neuroticism (Nagel 2018) 0.1 0.2 0.4 -0.4 -0.1 -0.7 -0.2
Schizophrenia (2018) 0.7 1.5 5.0 -0.3 -2.2 -0.2 -0.8
Schizophrenia vs Biploar Disorder 0.3 0.4 0.8 0.3 -0.9 -0.2 -0.7
Worry (Nagel 2018) 0.0 0.1 0.2 0.2 -0.5 0.1 0.3
Alzheimer’s Disease (in mother) 1.0 1.2 3.3 -0.2 -1.2 1.8 0.1
Alzheimer’s Disease (in father) 3.1 3.3 7.8 -0.1 0.7 -2.8 -2.2
Alzheimer’s Disease (including proxy) 0.5 0.8 1.9 -0.1 -1.0 -0.2 -1.4
Crohns Disease (2017) 0.5 1.0 1.6 0.9 0.5 1.2 1.2
Irritable Bowel Disease (IBD) 0.7 1.7 3.6 0.8 -0.2 1.9 1.6
Ulcerative Colitis (UC) 0.6 1.2 2.3 0.4 -1.0 1.5 1.0
Major Depression (MDD) 0.4 0.5 1.8 1.3 -0.5 -0.3 0.0
Reaction Time 0.3 0.6 0.9 1.0 1.0 -0.8 -0.1
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.4 -1.1 0.8 1.3 1.8
Breast Cancer 0.6 1.5 4.7 -0.3 -0.1 -1.2 -2.2
Ovarian Cancer 0.7 0.9 2.1 -1.5 0.4 -0.1 -1.2
Prostate Cancer 0.6 0.8 0.9 0.9 1.0 0.8 0.9
Age at First Birth 0.4 0.6 1.4 -0.9 -0.2 1.2 0.5
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 2.2 -0.1 -0.8 -0.7 -1.5
Coronary Artery Disease (CAD) 0.9 1.1 1.8 1.1 -1.4 0.7 -0.9
Crohns Disease (2012) 0.5 0.9 1.3 1.1 1.2 0.7 0.8
Mean Putamen Volume 0.9 1.0 3.0 1.7 0.1 -0.3 -1.0
Fasting Glucose 0.9 1.0 2.5 0.4 0.3 -1.2 -1.6
HbA1C 0.5 0.5 1.3 -1.1 0.7 0.3 0.4
HDL Cholesterol 0.4 0.6 1.0 -0.3 1.0 -0.7 -1.0
LDL Cholesterol 0.9 1.3 2.9 1.0 -0.4 1.2 1.7
Lupus 0.4 0.6 1.8 -0.3 0.6 -0.6 -1.3
Neuroticism (2016) 0.0 0.0 0.1 0.2 0.3 0.2 0.2
Primary Biliary Cirrhosis 1.0 1.4 2.1 1.5 -0.4 1.1 1.4
Rheumatoid Arthritis 0.7 1.0 1.7 -0.4 1.0 1.0 1.3
Schizophrenia (2014) 0.8 1.8 6.6 -0.4 -2.6 0.4 -0.4
Triglycerides 3.5 5.8 13.2 2.5 -3.6 -0.8 -1.7
Type 2 Diabetes (T2D) (2012) 0.9 1.1 2.3 -0.8 -0.7 -1.0 -1.5
Ulcerative Colitis 0.3 0.5 0.7 0.7 -0.6 0.5 0.8
Blood Eosinophil Count 0.4 3.1 5.6 -0.1 -2.0 2.4 1.7
Blood Platelet Count 0.4 4.1 12.1 -3.5 1.8 -0.7 -0.8
Blood Red Count 4.8 46.0 94.1 3.6 -9.7 -5.8 -6.6
Blood White Count 0.0 0.1 0.2 -0.2 0.4 -0.5 0.2
Heel T-Score 0.8 6.5 12.3 -1.2 0.3 -3.5 -3.5
BMI 1.9 10.8 17.7 0.2 -4.2 -3.1 -4.0
Height 4.6 88.3 151.3 -3.4 7.5 12.3 11.6
Waist Hip Ratio (WHR) 0.6 2.6 8.2 -2.9 -0.6 1.0 0.8
Systolic Blood Pressure 0.7 3.6 5.9 0.8 -1.8 2.4 2.2
Smoking Status 0.5 1.3 3.5 -0.4 -1.9 -0.9 -0.8
Allergy or Eczema 0.6 1.5 3.0 1.7 -1.6 -0.3 -0.7
Cardiovascular Disease 1.2 3.9 12.9 1.4 -3.6 0.6 -0.6
Hypothyroidism (self reported) 0.8 1.8 4.0 -0.2 -2.0 -0.6 -1.6
Respiratory disease 0.3 0.8 2.6 1.6 0.4 -0.6 0.0
Type 2 Diabetes (T2D) (2018) 0.8 1.5 5.4 -2.3 0.8 0.0 0.2
Lung FEV1/FVC ratio 0.8 4.0 9.2 -3.0 0.1 -2.2 -1.4
Lung FVC 0.6 3.2 10.5 -1.2 3.2 -0.4 0.9
Neuroticism 0.1 0.3 0.5 -0.5 -0.2 0.5 0.7
Chronotype (morning person) 3.0 7.0 20.7 2.4 -4.6 0.4 -1.3
Hair Pigment 0.0 0.3 0.5 0.4 0.3 -0.7 0.5
Tanning 0.1 1.3 3.1 -0.3 -0.3 -1.4 -1.8
Hand grip strength (left) 0.7 1.7 2.4 -1.6 1.6 1.2 0.8
Number of treatments/medications taken 2.2 3.9 11.7 1.9 -3.4 0.3 0.4
Average weekly spirits intake 0.2 0.3 0.7 0.8 0.2 -0.4 -0.4
Sensitivity / hurt feelings 0.2 0.4 0.7 -0.7 0.5 -0.3 0.9
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.3 -0.2 0.4 0.6 0.5
Hearing difficulty/problems: Yes 2.2 3.3 6.7 0.7 -2.6 -1.8 -1.7
Relative age of first facial hair 0.6 1.3 4.7 2.2 0.2 -0.0 -0.5
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 3.1 1.3 -1.8 0.4 0.7
Ever used hormone-replacement therapy (HRT) 1.3 1.7 3.8 -1.0 -1.9 -0.9 -1.0
Ever had hysterectomy (womb removed) 1.0 1.1 4.1 -0.1 -2.0 0.4 -0.4
Systolic blood pressure, automated reading 0.5 1.4 3.6 0.6 -1.9 1.2 0.6
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.8 0.4 -1.4 -0.7 -1.3
Angina 1.4 1.8 4.2 1.1 -0.1 -2.0 -1.3
Medication for hormone replacement therapy 1.4 1.6 5.6 2.4 -0.7 -0.4 -0.4
Vitamin and mineral supplements 0.2 0.2 0.7 -0.0 -0.0 0.4 0.8
Supplements: Zinc 1.9 2.0 5.0 1.0 -0.9 -1.1 -2.2
Medication: Co-codamol 1.0 1.1 2.6 -0.3 -0.2 -1.6 -1.3
Medication: Metformin 0.8 1.2 3.8 -1.9 -0.5 -0.3 0.7
Diabetes (father) 0.1 0.1 0.3 -0.2 0.4 -0.6 -0.2
Diabetes (mother) 0.0 0.0 0.0 -0.0 0.2 -0.0 0.2
Severe depression (siblings) 0.7 0.8 2.7 -0.6 1.6 0.0 0.0
Pack years adult smoking proportion 0.5 0.7 1.8 -0.4 -1.4 0.8 0.5
Impedance of leg (right) 0.5 2.2 5.6 -1.4 2.4 0.6 1.1
Leg fat-free mass (left) 0.7 3.8 9.6 -0.2 0.2 3.1 2.4
Trunk fat percentage 0.4 1.6 6.0 -0.7 -2.5 0.0 -0.3
Hand grip strength (right) 0.3 1.0 2.5 -1.1 1.6 -0.3 0.1
Townsend deprivation index at recruitment 0.1 0.1 0.3 -0.0 0.2 -0.2 -0.5
Current tobacco smoking 0.6 1.0 1.9 0.1 -0.3 1.4 1.3
Average weekly fortified wine intake 1.5 1.8 4.2 -1.7 2.0 -0.1 -0.3
Maternal smoking around birth 1.2 1.8 4.3 0.2 -0.5 -1.6 -2.1
Fed-up feelings 0.2 0.4 0.9 -0.6 0.5 -0.9 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.5 -0.2 1.2 -0.1 0.8
Relative age voice broke 0.2 0.3 0.5 0.7 0.7 0.3 -0.1
Taking other prescription medications 1.1 1.7 6.3 0.0 -2.5 0.4 0.7
Age when periods started (menarche) 1.4 3.3 6.4 -2.4 2.5 -0.7 -0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.0 -1.0 -0.5 0.9 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.6 1.3 -0.5 0.2 -1.1 -0.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 -0.4 -0.3 -0.4 -0.6
Qualifications: CSEs or equivalent 0.5 0.7 2.1 0.4 0.2 -1.4 -0.7
Serious illness, injury or assault to yourself 1.8 2.2 4.4 2.0 -2.1 0.4 -0.2
High blood pressure 1.9 5.4 15.1 1.4 -3.9 1.6 1.4
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.8 0.9 -1.3 -0.3 -0.7
Multivitamins +/- minerals 0.4 0.6 1.6 -1.3 -0.2 -0.0 -0.8
Stomach or abdominal pain in last month 0.3 0.4 0.8 0.4 0.5 0.9 0.7
Supplements: Glucosamine 1.1 1.4 4.5 -2.1 1.0 0.2 -0.2
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.7 0.9 -1.7 0.2 0.1
Medication: Atenolol 0.7 0.9 2.2 0.2 -0.6 -1.5 -0.9
Medication: Levothyroxine sodium 0.8 1.3 2.7 1.2 -1.6 1.1 0.0
Sitting height 2.4 17.1 39.3 0.2 2.2 6.3 4.9
Chronic bronchitis/emphysema (father) 1.3 1.6 3.6 -0.3 -1.9 1.4 0.9
High blood pressure (mother) 0.2 0.2 0.8 0.9 0.3 0.2 0.3
Body mass index (BMI) 1.1 4.8 9.9 0.6 -3.1 -2.1 -2.2
Impedance of leg (left) 0.7 3.3 8.2 -1.8 2.9 0.7 1.3
Leg predicted mass (left) 0.7 3.9 10.1 -0.2 0.1 3.2 2.4
Trunk fat mass 0.4 1.5 3.6 -0.8 -1.9 1.2 0.7
Waist circumference 0.3 1.1 4.3 0.1 -2.1 0.2 0.1
Number of incorrect matches in round 0.1 0.2 0.5 0.5 -0.7 -0.0 0.5
Past tobacco smoking 1.7 3.2 7.4 -0.1 1.2 1.9 2.7
Alcohol usually taken with meals 0.3 0.5 0.9 0.0 0.8 -0.7 -1.0
Nervous feelings 0.1 0.1 0.2 -0.4 0.4 0.4 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.1 -1.0 0.9 -1.0 -0.4
Hearing difficulty/problems with background noise 0.9 1.5 3.1 0.4 -1.8 -1.0 -1.2
Hair/balding pattern: Pattern 2 0.2 0.3 0.6 0.2 -0.4 -0.8 -0.6
Had menopause 0.8 1.0 1.6 0.9 -0.9 0.8 1.3
Had other major operations 0.3 0.3 0.8 0.3 -0.9 -0.5 0.2
Forced vital capacity (FVC) 3.8 14.5 25.5 -2.1 5.0 3.4 4.1
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 5.5 -0.7 0.4 -2.3 -1.7
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 2.1 1.0 0.3 -1.3 -1.4
Qualifications: None of the above 0.7 1.5 4.1 0.4 -2.0 0.8 0.9
Financial difficulties in last 2 years 2.0 2.6 8.8 -0.9 3.0 -0.9 0.3
Mouth/teeth dental problems 1.5 2.4 4.2 -2.0 1.9 -1.2 -0.5
Heart attack 1.3 1.7 3.2 0.2 -1.6 -1.1 -1.8
Allergy 0.5 1.1 3.0 -1.7 1.2 0.1 -0.1
Pain all over the body in last month 0.7 0.7 1.4 0.7 0.2 -1.2 -0.9
Diabetes (self-reported) 0.6 0.9 2.8 -1.7 0.6 -0.7 -0.1
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 3.5 -0.8 -1.9 0.1 -0.8
Medication: Ramipril 1.6 2.1 4.5 -1.3 -2.1 1.4 0.4
Medication: Simvastatin 1.3 2.0 4.1 -0.1 -2.0 -1.2 -1.5
Fluid intelligence score 0.5 1.0 1.5 -1.1 0.6 1.0 1.2
Illnesses of siblings 1.5 2.2 7.5 -0.1 2.7 0.4 1.0
Neuroticism score 0.2 0.4 0.5 -0.7 0.7 0.1 0.6
Weight 0.4 1.9 4.2 -0.6 -0.6 2.0 1.6
Impedance of arm (right) 0.7 3.1 6.7 -0.6 0.9 2.6 2.1
Arm fat percentage (right) 0.9 3.7 11.7 0.5 -3.4 -1.1 -1.4
Trunk fat-free mass 1.7 9.8 21.2 -0.8 1.8 4.6 3.8
Hip circumference 0.2 0.9 2.5 1.6 -0.8 0.6 0.3
Time employed in main current job 0.2 0.2 0.6 0.3 0.8 0.1 0.1
Alcohol intake versus 10 years previously 0.2 0.2 0.8 -0.2 -0.9 -0.4 -0.2
Father’s age at death 0.8 1.0 1.6 -0.7 1.2 1.0 1.0
Worrier / anxious feelings 0.2 0.3 0.5 -0.7 -0.4 0.7 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.4 0.3 0.9 -1.2 0.1
Falls in the last year 0.4 0.6 1.3 0.6 -1.2 0.4 0.7
Hair/balding pattern: Pattern 3 1.1 1.6 4.0 0.8 2.0 -0.8 -1.0
Number of live births 0.7 1.1 2.5 1.0 1.6 -0.7 -0.5
Forced expiratory volume in 1-second (FEV1) 3.1 10.5 20.2 -2.6 4.5 2.2 3.2
Pulse rate 2.0 3.3 9.2 -0.0 -3.0 -1.6 -1.3
Happiness 0.6 0.7 1.8 -1.3 0.5 0.8 0.3
Noisy workplace 0.1 0.1 0.2 0.2 -0.0 -0.5 0.2
Qualifications: A levels/AS levels or equivalent 1.9 4.3 9.9 -0.3 -1.2 3.1 2.4
Serious illness, injury or assault of a close relative in last 2 years 1.7 2.0 3.1 -0.8 1.4 1.4 1.8
Mouth/teeth dental problems: Dentures 2.2 3.7 12.1 1.5 -3.5 0.7 0.3
Asthma 0.2 0.4 1.3 1.2 -0.3 -0.5 0.2
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 6.3 2.5 -1.2 -0.6 -1.1
Medication: Cholesterol lowering 0.3 0.4 1.4 -0.3 -1.2 -0.3 0.0
Depression (self-reported) 0.2 0.2 0.5 0.7 -0.4 -0.1 -0.6
Medication: Lansoprazole 0.3 0.3 0.8 -0.3 -0.9 0.0 -0.6
Prospective memory result 1.2 1.5 2.9 0.1 -0.9 1.7 1.5
Lung cancer (father) 0.4 0.5 1.1 0.0 -1.1 -0.6 -0.8
Illnesses of mother 0.6 0.7 1.7 -1.3 0.2 0.6 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 2.7 8.7 18.0 -2.2 4.2 2.1 2.7
Pulse wave Arterial Stiffness index 0.1 0.1 0.1 0.2 0.3 -0.2 0.4
Impedance of arm (left) 0.3 1.4 2.9 -0.6 0.6 1.7 1.4
Arm fat mass (right) 0.3 1.4 5.6 0.1 -2.4 0.1 -0.3
Trunk predicted mass 1.7 9.8 21.4 -0.8 1.7 4.6 3.8
Standing height 4.5 44.5 79.9 -2.6 5.2 8.9 8.0
Length of working week for main job 0.6 0.7 1.2 -0.4 -1.1 -0.7 -0.9
Exposure to tobacco smoke at home 1.2 1.3 3.0 0.2 1.2 -1.7 -0.9
Breastfed as a baby 0.1 0.2 0.3 -0.4 -0.6 0.3 0.4
Tense / ‘highly strung’ 0.3 0.5 0.7 0.8 -0.4 0.7 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.7 -0.5 -0.0 -0.8
Hair/balding pattern: Pattern 4 0.4 0.9 2.0 -1.4 -0.4 1.1 0.3
Birth weight of first child 0.5 0.9 2.6 -0.2 -1.6 -0.7 -0.7
Peak expiratory flow (PEF) 0.8 1.9 2.2 -1.4 1.5 1.1 1.5
Pulse wave reflection index 0.3 0.4 1.0 0.6 0.1 -0.3 -1.0
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.3 1.1 -0.1 -1.0 -1.1
Loud music exposure frequency 1.5 1.6 2.9 0.6 -0.7 -1.7 -1.7
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 1.7 -0.5 1.1 0.8 1.3
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 3.2 0.8 1.8 0.9 0.9
Blood clot in the leg (DVT) 0.3 0.3 0.9 -1.0 -0.3 0.0 -0.6
Medication: Paracetamol 2.2 3.7 8.7 2.2 -3.0 -0.3 -1.1
Headache pain in last month 3.2 5.6 12.6 3.0 -3.6 0.1 -0.9
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.4 -0.3 1.8 -0.1 -0.7
Glaucoma (self-reported) 0.6 0.7 1.8 -0.4 -0.6 1.3 0.5
Gout (self-reported) 0.6 0.8 2.0 -0.0 -1.4 -1.0 -0.5
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 4.3 0.9 -2.1 -0.1 -1.2
Medication: Amlodipine 0.9 1.3 2.6 -0.8 -1.6 0.9 1.0
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.7 0.5 -0.1 -0.9 -0.1
Birth weight 0.8 1.8 5.1 0.8 -2.3 1.3 0.0
Chronic bronchitis/emphysema (mother) 1.5 1.8 2.6 1.6 1.4 -1.5 -0.6
High blood pressure (siblings) 2.3 3.2 7.1 0.7 -2.7 -1.1 -2.1
Forced vital capacity (FVC), Best measure 3.5 12.7 21.3 -1.7 4.6 3.5 3.8
Body fat percentage 0.6 2.3 7.3 -0.5 -2.7 -0.8 -1.0
Leg fat percentage (right) 0.7 2.7 6.5 -0.0 -2.6 -1.5 -1.3
Arm fat-free mass (right) 0.8 4.3 9.1 -0.9 0.8 3.0 2.6
Exposure to tobacco smoke outside home 1.2 1.6 3.2 -0.4 0.7 -1.8 -1.6
Comparative body size at age 10 1.9 5.2 11.2 2.2 -3.3 -1.6 -1.5
Number of full brothers 1.2 1.6 2.9 1.5 -1.7 -0.5 -1.0
Worry too long after embarrassment 0.2 0.3 0.6 0.8 0.3 -0.6 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.0 -0.0 0.3 -0.0
Wheeze or whistling in the chest in last year 0.3 0.6 1.0 0.8 -0.7 -1.0 -0.6
Number of children fathered 0.3 0.4 1.1 -0.1 -0.4 -0.5 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.0 -0.0 0.1 0.1 0.0
Age at first live birth 0.5 1.0 2.0 -0.8 0.8 1.4 0.7
Pulse wave peak to peak time 0.3 0.3 0.7 -0.7 0.2 0.8 0.2
Health satisfaction 1.0 1.3 4.0 0.3 -2.0 1.1 0.5
Shortness of breath walking on level ground 0.3 0.4 0.8 0.6 -0.9 0.6 -0.1
Qualifications: College or University degree 0.5 1.7 3.9 -0.4 0.6 2.0 1.6
Eye problems/disorders: None of the above 0.6 0.7 1.6 0.5 1.3 0.1 0.9
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.5 0.2 -0.1 -0.4 -1.2
Emphysema/chronic bronchitis 0.4 0.4 1.1 0.0 0.7 0.4 1.1
Medication for pain relief, constipation, heartburn 1.1 1.9 5.4 -1.3 2.3 -0.6 -0.7
Neck or shoulder pain in last month 0.6 0.8 1.6 0.1 -0.9 -1.3 -0.9
Medication: Blood pressure 0.7 1.2 3.4 -0.4 -1.9 0.5 0.9
Angina (self-reported) 1.2 1.6 3.9 0.8 -0.1 -2.0 -1.3
Migraine (self-reported) 0.8 1.0 2.7 0.0 -1.6 1.1 -0.1
Medication: Ibuprofen 2.0 2.4 8.0 2.8 -1.1 -0.1 -0.5
Medication: Allopurinol 0.5 0.7 1.7 -1.0 -1.3 -0.1 -0.3
Medication: Omeprazole 0.1 0.1 0.2 0.3 -0.4 -0.5 -0.2
Medication: Seretide 50 evohaler 0.9 1.0 1.6 -0.2 0.8 1.3 1.3
Mean time to correctly identify matches 0.2 0.4 1.0 0.2 1.0 -0.6 -0.1
Heart disease (mother) 1.9 2.3 4.8 0.9 -0.8 -2.2 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.7 0.6 -0.8 -0.1 -0.4
Whole body fat mass 0.3 1.0 3.3 -0.7 -1.8 0.6 0.2
Leg fat mass (right) 0.3 1.0 3.9 -0.3 -2.0 -0.1 -0.2
Arm predicted mass (right) 1.0 5.2 11.1 -1.1 0.7 3.3 2.8
Pulse rate, automated reading 2.3 7.4 21.5 -0.2 -4.6 -2.0 -2.0
Alcohol intake frequency. 2.0 4.7 12.0 3.5 -2.3 -1.0 -0.8
Comparative height size at age 10 3.5 19.3 34.1 -1.8 3.7 5.8 5.1
Number of full sisters 0.9 1.1 2.2 1.5 1.4 -0.1 0.6
Suffer from ‘nerves’ 0.3 0.5 0.8 -0.5 0.9 0.8 0.7
Overall health rating 0.9 2.0 7.3 0.0 -2.7 -0.6 -0.5
Chest pain or discomfort 0.2 0.3 0.4 0.2 -0.5 -0.6 -0.6
Had major operations 0.1 0.1 0.3 0.5 0.0 -0.1 -0.2
Age at last live birth 0.3 0.5 1.1 -0.1 1.0 0.9 -0.1
Family relationship satisfaction 2.4 2.9 8.8 -3.0 -0.8 1.3 0.6
Leg pain on walking 0.1 0.2 0.3 0.3 -0.5 -0.4 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 5.6 1.0 0.3 -1.4 -2.4
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.2 -1.2 1.5 -0.3 0.3
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 4.3 -0.3 -2.1 -0.5 -1.5
Medication: Aspirin 0.7 0.9 1.9 -0.6 -0.7 1.0 1.4
Supplements: Vitamin C 0.8 1.0 1.7 -0.2 1.3 -1.3 -0.8
Knee pain experienced in last month 0.5 0.8 2.8 0.6 -1.7 -0.3 -0.1
Hypertension (Self-reported) 2.0 5.4 16.0 1.0 -4.0 1.7 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 0.4 0.1 0.0 0.4
Illnesses of father: Heart disease 1.1 1.5 3.6 -0.9 -0.5 1.9 1.1
Illnesses of siblings: Diabetes 1.2 1.5 3.6 -0.8 -1.9 -0.2 -1.2
Smoking status: Previous 2.3 3.5 8.3 -0.3 -1.4 -1.9 -2.9
Forced expiratory volume in 1-second (FEV1), predicted 4.0 8.4 11.8 -2.1 3.4 2.8 3.0
Whole body fat-free mass 1.3 7.4 17.0 -0.6 1.1 4.1 3.3
Leg fat-free mass (right) 0.8 4.2 10.2 -0.3 0.5 3.2 2.5
Arm fat percentage (left) 1.2 4.8 14.3 0.4 -3.8 -1.4 -1.7
Average weekly red wine intake 1.0 1.4 4.8 -0.8 2.2 0.1 0.5
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.0 -0.1 -0.3 -1.0 -0.3
Mood swings 0.2 0.3 0.5 -0.7 -0.3 -0.4 -0.7
Loneliness, isolation 0.2 0.2 0.8 -0.1 -0.0 0.4 0.9
Long-standing illness, disability or infirmity 2.3 3.5 8.4 1.6 -2.9 1.5 1.1
Ever had bowel cancer screening 2.2 2.6 4.2 -2.0 0.5 1.7 1.8
Diabetes diagnosed by doctor 0.6 1.0 2.8 -1.7 -0.2 -1.1 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.0 0.9 0.4 -0.7 -1.0
Friendships satisfaction 1.3 1.6 4.3 -2.1 0.2 1.3 0.6
Qualifications: nursing, teaching 0.5 0.7 1.7 0.1 1.3 0.9 0.7
Commuting to job workplace: Walk 0.8 0.9 2.2 0.7 -1.5 0.8 0.1
Eye problems/disorders: Cataract 1.0 1.2 2.6 0.8 -0.6 -1.1 -1.6
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 3.5 1.9 -1.8 -0.2 -0.8
Medication for cholesterol 2.9 4.4 10.5 -2.3 3.2 -1.4 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 6.8 0.4 -2.6 1.3 0.6
Back pain experienced in last month 1.4 2.0 5.7 2.4 -1.2 0.6 0.8
Mineral and other dietary supplements 1.2 1.6 5.3 2.3 -0.9 -0.2 0.7
Breast cancer (self-reported) 1.0 1.1 2.2 1.1 -0.2 1.5 1.1
Asthma (self-reported) 0.3 0.5 1.8 1.4 -0.0 -0.5 0.3
Osteoporosis (self-reported) 0.5 0.6 2.2 0.1 0.2 -0.5 -1.5
Osteoarthritis (self-reported) 1.2 1.5 3.6 1.1 -1.9 1.0 -0.6
Medication: Aspirin 0.9 1.1 2.1 -0.4 -0.9 1.2 1.4
Medication: Gliclazide 0.6 0.7 1.1 -0.0 -1.1 0.7 1.0
Illnesses of father: None of the above (group 1) 0.9 1.1 2.2 -0.6 0.8 -1.5 -1.1
Smoking status: Current 0.3 0.5 1.1 0.6 -0.2 0.8 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.9 -0.6 1.4 0.2 1.0
Whole body water mass 1.2 6.8 15.9 -0.7 1.0 4.0 3.2
Leg predicted mass (right) 0.8 4.2 10.3 -0.2 0.5 3.2 2.5
Arm fat mass (left) 0.4 1.8 6.9 0.1 -2.6 -0.2 -0.5
Number of self-reported non-cancer illnesses 1.3 2.2 8.7 -0.1 -3.0 0.4 0.2
Average weekly champagne plus white wine intake 0.4 0.6 1.6 -0.4 1.3 0.0 0.8
Miserableness 0.3 0.4 1.0 -0.1 -0.4 -0.8 -1.0
Guilty feelings 0.3 0.5 1.7 -1.3 0.1 -0.3 0.0
Wears glasses or contact lenses 0.8 0.9 1.8 1.3 -1.1 0.7 0.1
Ever taken oral contraceptive pill 1.0 1.1 2.2 -0.3 0.6 1.3 1.5
Hearing aid user 4.5 5.1 7.5 1.8 -2.7 -2.0 -2.4
Mother’s age at death 0.3 0.4 1.1 -0.5 0.6 -1.0 0.1
Financial situation satisfaction 0.2 0.3 0.5 0.3 -0.2 -0.6 -0.7
Tinnitus: Yes, now most or all of the time 1.2 1.4 3.5 1.4 -1.9 0.3 0.2
Commuting to job workplace: Public transport 0.5 0.6 1.5 0.3 0.7 0.6 1.2
Eye problems/disorders: Glaucoma 0.4 0.5 1.6 -1.2 -0.6 -0.3 -0.0
Medication: Blood pressure 1.5 2.9 8.8 1.2 -3.0 0.9 0.7
Pain type(s) experienced in last month: Hip pain 1.1 1.4 4.0 0.2 -0.5 -1.1 -2.0
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.0 -1.4 1.4 0.2 0.0
High cholesterol (Self-reported) 3.5 6.1 10.9 0.4 -3.0 -2.1 -3.3
Medication: Bendroflumethiazide 0.9 1.4 4.2 1.2 -2.0 -0.2 0.2
Medication: Paracetamol 2.8 4.4 12.2 2.0 -3.5 -0.3 -1.1
Medication: Lisinopril 2.0 2.5 2.7 1.6 -1.5 1.6 1.6
Medication: Atorvastatin 2.0 2.4 6.2 1.7 -2.5 0.0 -0.9
Illnesses of father: High blood pressure 0.2 0.2 0.6 -0.5 0.2 0.1 0.8
Alcohol drinker status: Never 0.7 0.9 1.5 0.7 0.9 0.8 1.2
Ever smoked 0.2 0.4 0.9 -0.3 -0.3 -0.7 -0.9
Basal metabolic rate 1.0 5.3 12.4 -0.7 0.8 3.5 2.8
Leg fat percentage (left) 0.7 2.4 5.3 -0.4 -2.3 -1.6 -1.3
Arm fat-free mass (left) 1.1 5.6 11.4 -0.9 1.0 3.4 3.0
Number of operations (self-reported) 1.4 2.0 6.5 0.6 -2.6 -0.8 -0.8
Average weekly beer plus cider intake 0.2 0.3 0.5 0.1 0.7 0.5 0.5
Irritability 0.5 0.8 2.4 -1.6 0.7 -0.4 0.4
Risk taking 2.7 3.9 6.1 -2.5 -1.1 -1.9 -2.2
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.6 -0.8 -0.8 -0.1 -0.6
Fractured/broken bones in last 5 years 1.2 1.6 3.7 0.0 -0.9 1.9 1.3
Age started oral contraceptive pill 1.7 2.2 3.7 -0.8 -1.5 1.9 1.4
Diastolic blood pressure, automated reading 2.0 6.1 15.4 2.1 -3.9 -1.2 -1.6
Ever depressed for a whole week 0.1 0.1 0.3 -0.4 -0.1 0.5 0.4
Unable to work because of sickness or disability 1.6 2.1 5.3 0.4 -0.8 2.3 1.5
Commuting to job workplace: Cycle 0.5 0.6 1.1 1.0 0.2 -1.1 -0.5
Myopia 2.6 3.8 6.0 -1.9 1.2 2.4 2.0
Vascular/heart problems diagnosed by doctor 1.6 4.5 14.7 -1.1 3.8 -1.1 -0.8
Cholesterol lowering medication 2.7 4.0 9.9 1.2 -3.1 -0.8 -2.0
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.1 -0.3 -0.2 -0.1 0.0
Pain experienced in last month 3.6 6.0 13.2 -3.6 3.2 0.1 0.6
Supplements: Calcium 0.6 0.7 2.0 0.5 -1.4 0.3 -0.6
Basal cell carcinoma (self-reported) 1.8 2.2 4.3 0.8 0.8 2.1 1.8
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.6 -0.1 -1.3 -0.8 -1.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.2 -1.1 0.1 -0.4 -0.9
Heart disease (siblings) 0.4 0.5 1.6 0.7 -1.3 -0.0 0.2
Alcohol drinker status: Previous 0.5 0.6 1.3 1.1 -1.0 -0.3 -0.2
Pack years of smoking 0.6 0.8 2.6 -0.1 -1.6 0.8 0.2
Impedance of whole body 0.5 2.3 2.9 -1.2 1.6 1.5 1.7
Leg fat mass (left) 0.2 0.9 3.2 -0.4 -1.8 -0.2 -0.3
Arm predicted mass (left) 1.1 5.7 12.1 -1.0 0.9 3.5 3.0