Hub : Genes

PARP6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2410	0.0950	9.5e-05	0.063	NA	0.038	NA	0.075	4.2e-03	NA	2.1e-02	NA	1.9e-03
2	GTEx	Lung	0.0856	0.0528	1.8e-03	0.034	NA	0.007	NA	0.007	1.3e-03	NA	9.4e-02	NA	8.1e-02
3	GTEx	Nerve Tibial	0.0927	0.0460	2.9e-03	0.068	NA	0.036	NA	0.057	1.5e-05	NA	1.3e-03	NA	7.2e-05
4	GTEx	Thyroid	0.2270	0.0810	6.7e-05	0.020	NA	0.066	NA	0.030	1.1e-02	NA	9.0e-06	NA	2.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.6	-0.5	-1.3	0.4	0.2
Bipolar Disorder or Schizophrenia	0.7	1.8	6.4	-0.6	-2.5	0.1	-0.5
Depressed Affect (Nagel 2018)	0.3	0.7	1.6	-0.3	-0.2	-1.3	-1.0
Depression (Nagel 2018)	0.1	0.1	0.2	-0.2	0.4	-0.4	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.2	-1.1	0.3	0.4	0.9
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.4	-0.1	-0.7	-0.2
Schizophrenia (2018)	0.7	1.5	5.0	-0.3	-2.2	-0.2	-0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.3	-0.9	-0.2	-0.7
Worry (Nagel 2018)	0.0	0.1	0.2	0.2	-0.5	0.1	0.3
Alzheimer’s Disease (in mother)	1.0	1.2	3.3	-0.2	-1.2	1.8	0.1
Alzheimer’s Disease (in father)	3.1	3.3	7.8	-0.1	0.7	-2.8	-2.2
Alzheimer’s Disease (including proxy)	0.5	0.8	1.9	-0.1	-1.0	-0.2	-1.4
Crohns Disease (2017)	0.5	1.0	1.6	0.9	0.5	1.2	1.2
Irritable Bowel Disease (IBD)	0.7	1.7	3.6	0.8	-0.2	1.9	1.6
Ulcerative Colitis (UC)	0.6	1.2	2.3	0.4	-1.0	1.5	1.0
Major Depression (MDD)	0.4	0.5	1.8	1.3	-0.5	-0.3	0.0
Reaction Time	0.3	0.6	0.9	1.0	1.0	-0.8	-0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.4	-1.1	0.8	1.3	1.8
Breast Cancer	0.6	1.5	4.7	-0.3	-0.1	-1.2	-2.2
Ovarian Cancer	0.7	0.9	2.1	-1.5	0.4	-0.1	-1.2
Prostate Cancer	0.6	0.8	0.9	0.9	1.0	0.8	0.9
Age at First Birth	0.4	0.6	1.4	-0.9	-0.2	1.2	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	-0.1	-0.8	-0.7	-1.5
Coronary Artery Disease (CAD)	0.9	1.1	1.8	1.1	-1.4	0.7	-0.9
Crohns Disease (2012)	0.5	0.9	1.3	1.1	1.2	0.7	0.8
Mean Putamen Volume	0.9	1.0	3.0	1.7	0.1	-0.3	-1.0
Fasting Glucose	0.9	1.0	2.5	0.4	0.3	-1.2	-1.6
HbA1C	0.5	0.5	1.3	-1.1	0.7	0.3	0.4
HDL Cholesterol	0.4	0.6	1.0	-0.3	1.0	-0.7	-1.0
LDL Cholesterol	0.9	1.3	2.9	1.0	-0.4	1.2	1.7
Lupus	0.4	0.6	1.8	-0.3	0.6	-0.6	-1.3
Neuroticism (2016)	0.0	0.0	0.1	0.2	0.3	0.2	0.2
Primary Biliary Cirrhosis	1.0	1.4	2.1	1.5	-0.4	1.1	1.4
Rheumatoid Arthritis	0.7	1.0	1.7	-0.4	1.0	1.0	1.3
Schizophrenia (2014)	0.8	1.8	6.6	-0.4	-2.6	0.4	-0.4
Triglycerides	3.5	5.8	13.2	2.5	-3.6	-0.8	-1.7
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.3	-0.8	-0.7	-1.0	-1.5
Ulcerative Colitis	0.3	0.5	0.7	0.7	-0.6	0.5	0.8
Blood Eosinophil Count	0.4	3.1	5.6	-0.1	-2.0	2.4	1.7
Blood Platelet Count	0.4	4.1	12.1	-3.5	1.8	-0.7	-0.8
Blood Red Count	4.8	46.0	94.1	3.6	-9.7	-5.8	-6.6
Blood White Count	0.0	0.1	0.2	-0.2	0.4	-0.5	0.2
Heel T-Score	0.8	6.5	12.3	-1.2	0.3	-3.5	-3.5
BMI	1.9	10.8	17.7	0.2	-4.2	-3.1	-4.0
Height	4.6	88.3	151.3	-3.4	7.5	12.3	11.6
Waist Hip Ratio (WHR)	0.6	2.6	8.2	-2.9	-0.6	1.0	0.8
Systolic Blood Pressure	0.7	3.6	5.9	0.8	-1.8	2.4	2.2
Smoking Status	0.5	1.3	3.5	-0.4	-1.9	-0.9	-0.8
Allergy or Eczema	0.6	1.5	3.0	1.7	-1.6	-0.3	-0.7
Cardiovascular Disease	1.2	3.9	12.9	1.4	-3.6	0.6	-0.6
Hypothyroidism (self reported)	0.8	1.8	4.0	-0.2	-2.0	-0.6	-1.6
Respiratory disease	0.3	0.8	2.6	1.6	0.4	-0.6	0.0
Type 2 Diabetes (T2D) (2018)	0.8	1.5	5.4	-2.3	0.8	0.0	0.2
Lung FEV1/FVC ratio	0.8	4.0	9.2	-3.0	0.1	-2.2	-1.4
Lung FVC	0.6	3.2	10.5	-1.2	3.2	-0.4	0.9
Neuroticism	0.1	0.3	0.5	-0.5	-0.2	0.5	0.7
Chronotype (morning person)	3.0	7.0	20.7	2.4	-4.6	0.4	-1.3
Hair Pigment	0.0	0.3	0.5	0.4	0.3	-0.7	0.5
Tanning	0.1	1.3	3.1	-0.3	-0.3	-1.4	-1.8
Hand grip strength (left)	0.7	1.7	2.4	-1.6	1.6	1.2	0.8
Number of treatments/medications taken	2.2	3.9	11.7	1.9	-3.4	0.3	0.4
Average weekly spirits intake	0.2	0.3	0.7	0.8	0.2	-0.4	-0.4
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.7	0.5	-0.3	0.9
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.2	0.4	0.6	0.5
Hearing difficulty/problems: Yes	2.2	3.3	6.7	0.7	-2.6	-1.8	-1.7
Relative age of first facial hair	0.6	1.3	4.7	2.2	0.2	-0.0	-0.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.1	1.3	-1.8	0.4	0.7
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.8	-1.0	-1.9	-0.9	-1.0
Ever had hysterectomy (womb removed)	1.0	1.1	4.1	-0.1	-2.0	0.4	-0.4
Systolic blood pressure, automated reading	0.5	1.4	3.6	0.6	-1.9	1.2	0.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	0.4	-1.4	-0.7	-1.3
Angina	1.4	1.8	4.2	1.1	-0.1	-2.0	-1.3
Medication for hormone replacement therapy	1.4	1.6	5.6	2.4	-0.7	-0.4	-0.4
Vitamin and mineral supplements	0.2	0.2	0.7	-0.0	-0.0	0.4	0.8
Supplements: Zinc	1.9	2.0	5.0	1.0	-0.9	-1.1	-2.2
Medication: Co-codamol	1.0	1.1	2.6	-0.3	-0.2	-1.6	-1.3
Medication: Metformin	0.8	1.2	3.8	-1.9	-0.5	-0.3	0.7
Diabetes (father)	0.1	0.1	0.3	-0.2	0.4	-0.6	-0.2
Diabetes (mother)	0.0	0.0	0.0	-0.0	0.2	-0.0	0.2
Severe depression (siblings)	0.7	0.8	2.7	-0.6	1.6	0.0	0.0
Pack years adult smoking proportion	0.5	0.7	1.8	-0.4	-1.4	0.8	0.5
Impedance of leg (right)	0.5	2.2	5.6	-1.4	2.4	0.6	1.1
Leg fat-free mass (left)	0.7	3.8	9.6	-0.2	0.2	3.1	2.4
Trunk fat percentage	0.4	1.6	6.0	-0.7	-2.5	0.0	-0.3
Hand grip strength (right)	0.3	1.0	2.5	-1.1	1.6	-0.3	0.1
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.0	0.2	-0.2	-0.5
Current tobacco smoking	0.6	1.0	1.9	0.1	-0.3	1.4	1.3
Average weekly fortified wine intake	1.5	1.8	4.2	-1.7	2.0	-0.1	-0.3
Maternal smoking around birth	1.2	1.8	4.3	0.2	-0.5	-1.6	-2.1
Fed-up feelings	0.2	0.4	0.9	-0.6	0.5	-0.9	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	-0.2	1.2	-0.1	0.8
Relative age voice broke	0.2	0.3	0.5	0.7	0.7	0.3	-0.1
Taking other prescription medications	1.1	1.7	6.3	0.0	-2.5	0.4	0.7
Age when periods started (menarche)	1.4	3.3	6.4	-2.4	2.5	-0.7	-0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.0	-1.0	-0.5	0.9	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.3	-0.5	0.2	-1.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.4	-0.3	-0.4	-0.6
Qualifications: CSEs or equivalent	0.5	0.7	2.1	0.4	0.2	-1.4	-0.7
Serious illness, injury or assault to yourself	1.8	2.2	4.4	2.0	-2.1	0.4	-0.2
High blood pressure	1.9	5.4	15.1	1.4	-3.9	1.6	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	0.9	-1.3	-0.3	-0.7
Multivitamins +/- minerals	0.4	0.6	1.6	-1.3	-0.2	-0.0	-0.8
Stomach or abdominal pain in last month	0.3	0.4	0.8	0.4	0.5	0.9	0.7
Supplements: Glucosamine	1.1	1.4	4.5	-2.1	1.0	0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.7	0.9	-1.7	0.2	0.1
Medication: Atenolol	0.7	0.9	2.2	0.2	-0.6	-1.5	-0.9
Medication: Levothyroxine sodium	0.8	1.3	2.7	1.2	-1.6	1.1	0.0
Sitting height	2.4	17.1	39.3	0.2	2.2	6.3	4.9
Chronic bronchitis/emphysema (father)	1.3	1.6	3.6	-0.3	-1.9	1.4	0.9
High blood pressure (mother)	0.2	0.2	0.8	0.9	0.3	0.2	0.3
Body mass index (BMI)	1.1	4.8	9.9	0.6	-3.1	-2.1	-2.2
Impedance of leg (left)	0.7	3.3	8.2	-1.8	2.9	0.7	1.3
Leg predicted mass (left)	0.7	3.9	10.1	-0.2	0.1	3.2	2.4
Trunk fat mass	0.4	1.5	3.6	-0.8	-1.9	1.2	0.7
Waist circumference	0.3	1.1	4.3	0.1	-2.1	0.2	0.1
Number of incorrect matches in round	0.1	0.2	0.5	0.5	-0.7	-0.0	0.5
Past tobacco smoking	1.7	3.2	7.4	-0.1	1.2	1.9	2.7
Alcohol usually taken with meals	0.3	0.5	0.9	0.0	0.8	-0.7	-1.0
Nervous feelings	0.1	0.1	0.2	-0.4	0.4	0.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.1	-1.0	0.9	-1.0	-0.4
Hearing difficulty/problems with background noise	0.9	1.5	3.1	0.4	-1.8	-1.0	-1.2
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.2	-0.4	-0.8	-0.6
Had menopause	0.8	1.0	1.6	0.9	-0.9	0.8	1.3
Had other major operations	0.3	0.3	0.8	0.3	-0.9	-0.5	0.2
Forced vital capacity (FVC)	3.8	14.5	25.5	-2.1	5.0	3.4	4.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	5.5	-0.7	0.4	-2.3	-1.7
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.1	1.0	0.3	-1.3	-1.4
Qualifications: None of the above	0.7	1.5	4.1	0.4	-2.0	0.8	0.9
Financial difficulties in last 2 years	2.0	2.6	8.8	-0.9	3.0	-0.9	0.3
Mouth/teeth dental problems	1.5	2.4	4.2	-2.0	1.9	-1.2	-0.5
Heart attack	1.3	1.7	3.2	0.2	-1.6	-1.1	-1.8
Allergy	0.5	1.1	3.0	-1.7	1.2	0.1	-0.1
Pain all over the body in last month	0.7	0.7	1.4	0.7	0.2	-1.2	-0.9
Diabetes (self-reported)	0.6	0.9	2.8	-1.7	0.6	-0.7	-0.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.5	-0.8	-1.9	0.1	-0.8
Medication: Ramipril	1.6	2.1	4.5	-1.3	-2.1	1.4	0.4
Medication: Simvastatin	1.3	2.0	4.1	-0.1	-2.0	-1.2	-1.5
Fluid intelligence score	0.5	1.0	1.5	-1.1	0.6	1.0	1.2
Illnesses of siblings	1.5	2.2	7.5	-0.1	2.7	0.4	1.0
Neuroticism score	0.2	0.4	0.5	-0.7	0.7	0.1	0.6
Weight	0.4	1.9	4.2	-0.6	-0.6	2.0	1.6
Impedance of arm (right)	0.7	3.1	6.7	-0.6	0.9	2.6	2.1
Arm fat percentage (right)	0.9	3.7	11.7	0.5	-3.4	-1.1	-1.4
Trunk fat-free mass	1.7	9.8	21.2	-0.8	1.8	4.6	3.8
Hip circumference	0.2	0.9	2.5	1.6	-0.8	0.6	0.3
Time employed in main current job	0.2	0.2	0.6	0.3	0.8	0.1	0.1
Alcohol intake versus 10 years previously	0.2	0.2	0.8	-0.2	-0.9	-0.4	-0.2
Father’s age at death	0.8	1.0	1.6	-0.7	1.2	1.0	1.0
Worrier / anxious feelings	0.2	0.3	0.5	-0.7	-0.4	0.7	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.4	0.3	0.9	-1.2	0.1
Falls in the last year	0.4	0.6	1.3	0.6	-1.2	0.4	0.7
Hair/balding pattern: Pattern 3	1.1	1.6	4.0	0.8	2.0	-0.8	-1.0
Number of live births	0.7	1.1	2.5	1.0	1.6	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1)	3.1	10.5	20.2	-2.6	4.5	2.2	3.2
Pulse rate	2.0	3.3	9.2	-0.0	-3.0	-1.6	-1.3
Happiness	0.6	0.7	1.8	-1.3	0.5	0.8	0.3
Noisy workplace	0.1	0.1	0.2	0.2	-0.0	-0.5	0.2
Qualifications: A levels/AS levels or equivalent	1.9	4.3	9.9	-0.3	-1.2	3.1	2.4
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	3.1	-0.8	1.4	1.4	1.8
Mouth/teeth dental problems: Dentures	2.2	3.7	12.1	1.5	-3.5	0.7	0.3
Asthma	0.2	0.4	1.3	1.2	-0.3	-0.5	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	6.3	2.5	-1.2	-0.6	-1.1
Medication: Cholesterol lowering	0.3	0.4	1.4	-0.3	-1.2	-0.3	0.0
Depression (self-reported)	0.2	0.2	0.5	0.7	-0.4	-0.1	-0.6
Medication: Lansoprazole	0.3	0.3	0.8	-0.3	-0.9	0.0	-0.6
Prospective memory result	1.2	1.5	2.9	0.1	-0.9	1.7	1.5
Lung cancer (father)	0.4	0.5	1.1	0.0	-1.1	-0.6	-0.8
Illnesses of mother	0.6	0.7	1.7	-1.3	0.2	0.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.7	18.0	-2.2	4.2	2.1	2.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	0.2	0.3	-0.2	0.4
Impedance of arm (left)	0.3	1.4	2.9	-0.6	0.6	1.7	1.4
Arm fat mass (right)	0.3	1.4	5.6	0.1	-2.4	0.1	-0.3
Trunk predicted mass	1.7	9.8	21.4	-0.8	1.7	4.6	3.8
Standing height	4.5	44.5	79.9	-2.6	5.2	8.9	8.0
Length of working week for main job	0.6	0.7	1.2	-0.4	-1.1	-0.7	-0.9
Exposure to tobacco smoke at home	1.2	1.3	3.0	0.2	1.2	-1.7	-0.9
Breastfed as a baby	0.1	0.2	0.3	-0.4	-0.6	0.3	0.4
Tense / ‘highly strung’	0.3	0.5	0.7	0.8	-0.4	0.7	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.7	-0.5	-0.0	-0.8
Hair/balding pattern: Pattern 4	0.4	0.9	2.0	-1.4	-0.4	1.1	0.3
Birth weight of first child	0.5	0.9	2.6	-0.2	-1.6	-0.7	-0.7
Peak expiratory flow (PEF)	0.8	1.9	2.2	-1.4	1.5	1.1	1.5
Pulse wave reflection index	0.3	0.4	1.0	0.6	0.1	-0.3	-1.0
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.3	1.1	-0.1	-1.0	-1.1
Loud music exposure frequency	1.5	1.6	2.9	0.6	-0.7	-1.7	-1.7
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.7	-0.5	1.1	0.8	1.3
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.2	0.8	1.8	0.9	0.9
Blood clot in the leg (DVT)	0.3	0.3	0.9	-1.0	-0.3	0.0	-0.6
Medication: Paracetamol	2.2	3.7	8.7	2.2	-3.0	-0.3	-1.1
Headache pain in last month	3.2	5.6	12.6	3.0	-3.6	0.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.4	-0.3	1.8	-0.1	-0.7
Glaucoma (self-reported)	0.6	0.7	1.8	-0.4	-0.6	1.3	0.5
Gout (self-reported)	0.6	0.8	2.0	-0.0	-1.4	-1.0	-0.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.3	0.9	-2.1	-0.1	-1.2
Medication: Amlodipine	0.9	1.3	2.6	-0.8	-1.6	0.9	1.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	0.5	-0.1	-0.9	-0.1
Birth weight	0.8	1.8	5.1	0.8	-2.3	1.3	0.0
Chronic bronchitis/emphysema (mother)	1.5	1.8	2.6	1.6	1.4	-1.5	-0.6
High blood pressure (siblings)	2.3	3.2	7.1	0.7	-2.7	-1.1	-2.1
Forced vital capacity (FVC), Best measure	3.5	12.7	21.3	-1.7	4.6	3.5	3.8
Body fat percentage	0.6	2.3	7.3	-0.5	-2.7	-0.8	-1.0
Leg fat percentage (right)	0.7	2.7	6.5	-0.0	-2.6	-1.5	-1.3
Arm fat-free mass (right)	0.8	4.3	9.1	-0.9	0.8	3.0	2.6
Exposure to tobacco smoke outside home	1.2	1.6	3.2	-0.4	0.7	-1.8	-1.6
Comparative body size at age 10	1.9	5.2	11.2	2.2	-3.3	-1.6	-1.5
Number of full brothers	1.2	1.6	2.9	1.5	-1.7	-0.5	-1.0
Worry too long after embarrassment	0.2	0.3	0.6	0.8	0.3	-0.6	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.0	-0.0	0.3	-0.0
Wheeze or whistling in the chest in last year	0.3	0.6	1.0	0.8	-0.7	-1.0	-0.6
Number of children fathered	0.3	0.4	1.1	-0.1	-0.4	-0.5	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.0	0.1	0.1	0.0
Age at first live birth	0.5	1.0	2.0	-0.8	0.8	1.4	0.7
Pulse wave peak to peak time	0.3	0.3	0.7	-0.7	0.2	0.8	0.2
Health satisfaction	1.0	1.3	4.0	0.3	-2.0	1.1	0.5
Shortness of breath walking on level ground	0.3	0.4	0.8	0.6	-0.9	0.6	-0.1
Qualifications: College or University degree	0.5	1.7	3.9	-0.4	0.6	2.0	1.6
Eye problems/disorders: None of the above	0.6	0.7	1.6	0.5	1.3	0.1	0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.5	0.2	-0.1	-0.4	-1.2
Emphysema/chronic bronchitis	0.4	0.4	1.1	0.0	0.7	0.4	1.1
Medication for pain relief, constipation, heartburn	1.1	1.9	5.4	-1.3	2.3	-0.6	-0.7
Neck or shoulder pain in last month	0.6	0.8	1.6	0.1	-0.9	-1.3	-0.9
Medication: Blood pressure	0.7	1.2	3.4	-0.4	-1.9	0.5	0.9
Angina (self-reported)	1.2	1.6	3.9	0.8	-0.1	-2.0	-1.3
Migraine (self-reported)	0.8	1.0	2.7	0.0	-1.6	1.1	-0.1
Medication: Ibuprofen	2.0	2.4	8.0	2.8	-1.1	-0.1	-0.5
Medication: Allopurinol	0.5	0.7	1.7	-1.0	-1.3	-0.1	-0.3
Medication: Omeprazole	0.1	0.1	0.2	0.3	-0.4	-0.5	-0.2
Medication: Seretide 50 evohaler	0.9	1.0	1.6	-0.2	0.8	1.3	1.3
Mean time to correctly identify matches	0.2	0.4	1.0	0.2	1.0	-0.6	-0.1
Heart disease (mother)	1.9	2.3	4.8	0.9	-0.8	-2.2	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.7	0.6	-0.8	-0.1	-0.4
Whole body fat mass	0.3	1.0	3.3	-0.7	-1.8	0.6	0.2
Leg fat mass (right)	0.3	1.0	3.9	-0.3	-2.0	-0.1	-0.2
Arm predicted mass (right)	1.0	5.2	11.1	-1.1	0.7	3.3	2.8
Pulse rate, automated reading	2.3	7.4	21.5	-0.2	-4.6	-2.0	-2.0
Alcohol intake frequency.	2.0	4.7	12.0	3.5	-2.3	-1.0	-0.8
Comparative height size at age 10	3.5	19.3	34.1	-1.8	3.7	5.8	5.1
Number of full sisters	0.9	1.1	2.2	1.5	1.4	-0.1	0.6
Suffer from ‘nerves’	0.3	0.5	0.8	-0.5	0.9	0.8	0.7
Overall health rating	0.9	2.0	7.3	0.0	-2.7	-0.6	-0.5
Chest pain or discomfort	0.2	0.3	0.4	0.2	-0.5	-0.6	-0.6
Had major operations	0.1	0.1	0.3	0.5	0.0	-0.1	-0.2
Age at last live birth	0.3	0.5	1.1	-0.1	1.0	0.9	-0.1
Family relationship satisfaction	2.4	2.9	8.8	-3.0	-0.8	1.3	0.6
Leg pain on walking	0.1	0.2	0.3	0.3	-0.5	-0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	5.6	1.0	0.3	-1.4	-2.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.2	-1.2	1.5	-0.3	0.3
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.3	-0.3	-2.1	-0.5	-1.5
Medication: Aspirin	0.7	0.9	1.9	-0.6	-0.7	1.0	1.4
Supplements: Vitamin C	0.8	1.0	1.7	-0.2	1.3	-1.3	-0.8
Knee pain experienced in last month	0.5	0.8	2.8	0.6	-1.7	-0.3	-0.1
Hypertension (Self-reported)	2.0	5.4	16.0	1.0	-4.0	1.7	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.4	0.1	0.0	0.4
Illnesses of father: Heart disease	1.1	1.5	3.6	-0.9	-0.5	1.9	1.1
Illnesses of siblings: Diabetes	1.2	1.5	3.6	-0.8	-1.9	-0.2	-1.2
Smoking status: Previous	2.3	3.5	8.3	-0.3	-1.4	-1.9	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	4.0	8.4	11.8	-2.1	3.4	2.8	3.0
Whole body fat-free mass	1.3	7.4	17.0	-0.6	1.1	4.1	3.3
Leg fat-free mass (right)	0.8	4.2	10.2	-0.3	0.5	3.2	2.5
Arm fat percentage (left)	1.2	4.8	14.3	0.4	-3.8	-1.4	-1.7
Average weekly red wine intake	1.0	1.4	4.8	-0.8	2.2	0.1	0.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.0	-0.1	-0.3	-1.0	-0.3
Mood swings	0.2	0.3	0.5	-0.7	-0.3	-0.4	-0.7
Loneliness, isolation	0.2	0.2	0.8	-0.1	-0.0	0.4	0.9
Long-standing illness, disability or infirmity	2.3	3.5	8.4	1.6	-2.9	1.5	1.1
Ever had bowel cancer screening	2.2	2.6	4.2	-2.0	0.5	1.7	1.8
Diabetes diagnosed by doctor	0.6	1.0	2.8	-1.7	-0.2	-1.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.0	0.9	0.4	-0.7	-1.0
Friendships satisfaction	1.3	1.6	4.3	-2.1	0.2	1.3	0.6
Qualifications: nursing, teaching	0.5	0.7	1.7	0.1	1.3	0.9	0.7
Commuting to job workplace: Walk	0.8	0.9	2.2	0.7	-1.5	0.8	0.1
Eye problems/disorders: Cataract	1.0	1.2	2.6	0.8	-0.6	-1.1	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.5	1.9	-1.8	-0.2	-0.8
Medication for cholesterol	2.9	4.4	10.5	-2.3	3.2	-1.4	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	6.8	0.4	-2.6	1.3	0.6
Back pain experienced in last month	1.4	2.0	5.7	2.4	-1.2	0.6	0.8
Mineral and other dietary supplements	1.2	1.6	5.3	2.3	-0.9	-0.2	0.7
Breast cancer (self-reported)	1.0	1.1	2.2	1.1	-0.2	1.5	1.1
Asthma (self-reported)	0.3	0.5	1.8	1.4	-0.0	-0.5	0.3
Osteoporosis (self-reported)	0.5	0.6	2.2	0.1	0.2	-0.5	-1.5
Osteoarthritis (self-reported)	1.2	1.5	3.6	1.1	-1.9	1.0	-0.6
Medication: Aspirin	0.9	1.1	2.1	-0.4	-0.9	1.2	1.4
Medication: Gliclazide	0.6	0.7	1.1	-0.0	-1.1	0.7	1.0
Illnesses of father: None of the above (group 1)	0.9	1.1	2.2	-0.6	0.8	-1.5	-1.1
Smoking status: Current	0.3	0.5	1.1	0.6	-0.2	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	-0.6	1.4	0.2	1.0
Whole body water mass	1.2	6.8	15.9	-0.7	1.0	4.0	3.2
Leg predicted mass (right)	0.8	4.2	10.3	-0.2	0.5	3.2	2.5
Arm fat mass (left)	0.4	1.8	6.9	0.1	-2.6	-0.2	-0.5
Number of self-reported non-cancer illnesses	1.3	2.2	8.7	-0.1	-3.0	0.4	0.2
Average weekly champagne plus white wine intake	0.4	0.6	1.6	-0.4	1.3	0.0	0.8
Miserableness	0.3	0.4	1.0	-0.1	-0.4	-0.8	-1.0
Guilty feelings	0.3	0.5	1.7	-1.3	0.1	-0.3	0.0
Wears glasses or contact lenses	0.8	0.9	1.8	1.3	-1.1	0.7	0.1
Ever taken oral contraceptive pill	1.0	1.1	2.2	-0.3	0.6	1.3	1.5
Hearing aid user	4.5	5.1	7.5	1.8	-2.7	-2.0	-2.4
Mother’s age at death	0.3	0.4	1.1	-0.5	0.6	-1.0	0.1
Financial situation satisfaction	0.2	0.3	0.5	0.3	-0.2	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.5	1.4	-1.9	0.3	0.2
Commuting to job workplace: Public transport	0.5	0.6	1.5	0.3	0.7	0.6	1.2
Eye problems/disorders: Glaucoma	0.4	0.5	1.6	-1.2	-0.6	-0.3	-0.0
Medication: Blood pressure	1.5	2.9	8.8	1.2	-3.0	0.9	0.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	4.0	0.2	-0.5	-1.1	-2.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.0	-1.4	1.4	0.2	0.0
High cholesterol (Self-reported)	3.5	6.1	10.9	0.4	-3.0	-2.1	-3.3
Medication: Bendroflumethiazide	0.9	1.4	4.2	1.2	-2.0	-0.2	0.2
Medication: Paracetamol	2.8	4.4	12.2	2.0	-3.5	-0.3	-1.1
Medication: Lisinopril	2.0	2.5	2.7	1.6	-1.5	1.6	1.6
Medication: Atorvastatin	2.0	2.4	6.2	1.7	-2.5	0.0	-0.9
Illnesses of father: High blood pressure	0.2	0.2	0.6	-0.5	0.2	0.1	0.8
Alcohol drinker status: Never	0.7	0.9	1.5	0.7	0.9	0.8	1.2
Ever smoked	0.2	0.4	0.9	-0.3	-0.3	-0.7	-0.9
Basal metabolic rate	1.0	5.3	12.4	-0.7	0.8	3.5	2.8
Leg fat percentage (left)	0.7	2.4	5.3	-0.4	-2.3	-1.6	-1.3
Arm fat-free mass (left)	1.1	5.6	11.4	-0.9	1.0	3.4	3.0
Number of operations (self-reported)	1.4	2.0	6.5	0.6	-2.6	-0.8	-0.8
Average weekly beer plus cider intake	0.2	0.3	0.5	0.1	0.7	0.5	0.5
Irritability	0.5	0.8	2.4	-1.6	0.7	-0.4	0.4
Risk taking	2.7	3.9	6.1	-2.5	-1.1	-1.9	-2.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	-0.8	-0.8	-0.1	-0.6
Fractured/broken bones in last 5 years	1.2	1.6	3.7	0.0	-0.9	1.9	1.3
Age started oral contraceptive pill	1.7	2.2	3.7	-0.8	-1.5	1.9	1.4
Diastolic blood pressure, automated reading	2.0	6.1	15.4	2.1	-3.9	-1.2	-1.6
Ever depressed for a whole week	0.1	0.1	0.3	-0.4	-0.1	0.5	0.4
Unable to work because of sickness or disability	1.6	2.1	5.3	0.4	-0.8	2.3	1.5
Commuting to job workplace: Cycle	0.5	0.6	1.1	1.0	0.2	-1.1	-0.5
Myopia	2.6	3.8	6.0	-1.9	1.2	2.4	2.0
Vascular/heart problems diagnosed by doctor	1.6	4.5	14.7	-1.1	3.8	-1.1	-0.8
Cholesterol lowering medication	2.7	4.0	9.9	1.2	-3.1	-0.8	-2.0
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.0
Pain experienced in last month	3.6	6.0	13.2	-3.6	3.2	0.1	0.6
Supplements: Calcium	0.6	0.7	2.0	0.5	-1.4	0.3	-0.6
Basal cell carcinoma (self-reported)	1.8	2.2	4.3	0.8	0.8	2.1	1.8
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.6	-0.1	-1.3	-0.8	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.2	-1.1	0.1	-0.4	-0.9
Heart disease (siblings)	0.4	0.5	1.6	0.7	-1.3	-0.0	0.2
Alcohol drinker status: Previous	0.5	0.6	1.3	1.1	-1.0	-0.3	-0.2
Pack years of smoking	0.6	0.8	2.6	-0.1	-1.6	0.8	0.2
Impedance of whole body	0.5	2.3	2.9	-1.2	1.6	1.5	1.7
Leg fat mass (left)	0.2	0.9	3.2	-0.4	-1.8	-0.2	-0.3
Arm predicted mass (left)	1.1	5.7	12.1	-1.0	0.9	3.5	3.0